glyburide has been researched along with Fetal Macrosomia in 22 studies
Glyburide: An antidiabetic sulfonylurea derivative with actions like those of chlorpropamide
glyburide : An N-sulfonylurea that is acetohexamide in which the acetyl group is replaced by a 2-(5-chloro-2-methoxybenzamido)ethyl group.
Fetal Macrosomia: A condition of fetal overgrowth leading to a large-for-gestational-age FETUS. It is defined as BIRTH WEIGHT greater than 4,000 grams or above the 90th percentile for population and sex-specific growth curves. It is commonly seen in GESTATIONAL DIABETES; PROLONGED PREGNANCY; and pregnancies complicated by pre-existing diabetes mellitus.
| Excerpt | Relevance | Reference |
|---|---|---|
| " As with other oral hypoglycemics, the use of glyburide in pregnancy has been limited by fears of neonatal hypoglycemia following fetal exposure." | 8.84 | Safety of glyburide for gestational diabetes: a meta-analysis of pregnancy outcomes. ( Koren, G; Moretti, ME; Rezvani, M, 2008) |
| "We sought to investigate the association between glyburide dose, degree of severity in gestational diabetes mellitus (GDM), level of glycemic control, and pregnancy outcome in insulin- and glyburide-treated patients." | 7.73 | Insulin and glyburide therapy: dosage, severity level of gestational diabetes, and pregnancy outcome. ( Langer, O; Rosenn, B; Xenakis, EM; Yogev, Y, 2005) |
| "Our study concluded that metformin is fastest in glucose control, with a more favorable pregnancy outcomes-would be a better option, but its rate of glucose control is the lowest." | 4.95 | Comparative efficacy and safety of oral antidiabetic drugs and insulin in treating gestational diabetes mellitus: An updated PRISMA-compliant network meta-analysis. ( Liang, HL; Ma, SJ; Tan, HZ; Xiao, YN, 2017) |
| " As with other oral hypoglycemics, the use of glyburide in pregnancy has been limited by fears of neonatal hypoglycemia following fetal exposure." | 4.84 | Safety of glyburide for gestational diabetes: a meta-analysis of pregnancy outcomes. ( Koren, G; Moretti, ME; Rezvani, M, 2008) |
| " Average infant birth weight may be lower in mothers treated with insulin than with glyburide." | 4.84 | Therapeutic management, delivery, and postpartum risk assessment and screening in gestational diabetes. ( Baptiste-Roberts, K; Barone, BB; Bass, EB; Bennett, WL; Bolen, S; Gary, TL; Golden, SH; Neale, DM; Nicholson, WK; Wilson, LM; Witkop, CT, 2008) |
| "4%) had at least one episode of hypoglycemia, most often in the setting of glyburide." | 4.12 | Antenatal maternal hypoglycemia in women with gestational diabetes mellitus and neonatal outcomes. ( Cruz, M; Davitt, C; Harrison, RK; Palatnik, A; Saravanan, V, 2022) |
| "The 5 mg/day glyburide dose did not increase maternal hypoglycemia (26% in the 2." | 3.83 | Examining the Starting Dose of Glyburide in Gestational Diabetes. ( Biggio, JR; Glover, AV; Harper, LM; Tita, A, 2016) |
| "We sought to investigate the association between glyburide dose, degree of severity in gestational diabetes mellitus (GDM), level of glycemic control, and pregnancy outcome in insulin- and glyburide-treated patients." | 3.73 | Insulin and glyburide therapy: dosage, severity level of gestational diabetes, and pregnancy outcome. ( Langer, O; Rosenn, B; Xenakis, EM; Yogev, Y, 2005) |
| "Glyburide was more likely to fail in women diagnosed earlier in pregnancy, of older age and multiparity, and with higher fasting glucoses, suggesting that earlier glucose intolerance and a reduced capacity to respond to an insulin secretagogue may distinguish this group." | 3.73 | Predictors of glyburide failure in the treatment of gestational diabetes. ( Barbour, LA; Davies, JK; Kahn, BF; Lynch, AM; Reynolds, RM, 2006) |
| " The starting dosage for glyburide was 2." | 2.87 | Effect of Glyburide vs Subcutaneous Insulin on Perinatal Complications Among Women With Gestational Diabetes: A Randomized Clinical Trial. ( Affres, H; Beucher, G; Bourcigaux, N; Bouyer, J; Bretelle, F; Castera, V; Cazaubiel, M; Coustols-Valat, M; De Carne, C; Deruelle, P; Desbriere, R; Héron, I; Jacquier, JF; Laboureau, S; Legardeur, H; Letourneau, A; Maillot, F; Mitanchez, D; Morin, M; Rod, A; Rolland, C; Sénat, MV; Sentilhes, L; Simon, E; Verspyck, E, 2018) |
| "In a south Indian population with gestational diabetes, metformin was associated with better neonatal outcomes than glibenclamide." | 2.80 | Comparison of neonatal outcomes in women with gestational diabetes with moderate hyperglycaemia on metformin or glibenclamide--a randomised controlled trial. ( Abraham, A; Antonisamy, B; Beck, M; Benjamin, SJ; George, A; Jana, AK; Mathews, JE; Sam, D; Thomas, N, 2015) |
| "Neonatal hypoglycemia was observed in eight newborns, six of which from the glyburide group." | 2.71 | Perinatal outcomes and the use of oral hypoglycemic agents. ( Aquim, G; Becker, F; Bertini, AM; Engel Ribeiro, T; Lemos Bebber, FR; Silva, JC; Taborda, W; Zucco Viesi, JM, 2005) |
| "Women with gestational diabetes mellitus are rarely treated with a sulfonylurea drug, because of concern about teratogenicity and neonatal hypoglycemia." | 2.69 | A comparison of glyburide and insulin in women with gestational diabetes mellitus. ( Berkus, MD; Conway, DL; Gonzales, O; Langer, O; Xenakis, EM, 2000) |
| "Fetal growth in gestational diabetes mellitus (GDM) is directly linked to maternal glycaemic control; however, this relationship may be altered by oral anti-hyperglycaemic agents." | 2.66 | Comparative impact of pharmacological treatments for gestational diabetes on neonatal anthropometry independent of maternal glycaemic control: A systematic review and meta-analysis. ( Aiken, CE; Ozanne, SE; Tarry-Adkins, JL, 2020) |
| "At short term, in women with gestational diabetes requiring drug treatment, glibenclamide is clearly inferior to both insulin and metformin, while metformin (plus insulin when required) performs slightly better than insulin." | 2.52 | Glibenclamide, metformin, and insulin for the treatment of gestational diabetes: a systematic review and meta-analysis. ( Balsells, M; Corcoy, R; García-Patterson, A; Gich, I; Roqué, M; Solà, I, 2015) |
| "The pregnancy outcome of 33 women with gestational diabetes who were treated with glibenclamide and changed to insulin if glibenclamide failed, were compared with the pregnancy outcome of 21 women with gestational diabetes treated conventionally with insulin." | 1.30 | A comparison between the pregnancy outcome of women with gestation diabetes treated with glibenclamide and those treated with insulin. ( Lim, JM; O'Brien, PM; Shaw, RW; Tayob, Y, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (4.55) | 18.2507 |
| 2000's | 10 (45.45) | 29.6817 |
| 2010's | 8 (36.36) | 24.3611 |
| 2020's | 3 (13.64) | 2.80 |
| Authors | Studies |
|---|---|
| Harrison, RK | 1 |
| Saravanan, V | 1 |
| Davitt, C | 1 |
| Cruz, M | 1 |
| Palatnik, A | 1 |
| Tarry-Adkins, JL | 1 |
| Aiken, CE | 1 |
| Ozanne, SE | 1 |
| Stanik, J | 1 |
| Barak, L | 1 |
| Dankovcikova, A | 1 |
| Valkovicova, T | 1 |
| Skopkova, M | 1 |
| Gasperikova, D | 1 |
| Liang, HL | 1 |
| Ma, SJ | 1 |
| Xiao, YN | 1 |
| Tan, HZ | 1 |
| Sénat, MV | 1 |
| Affres, H | 1 |
| Letourneau, A | 1 |
| Coustols-Valat, M | 1 |
| Cazaubiel, M | 1 |
| Legardeur, H | 1 |
| Jacquier, JF | 1 |
| Bourcigaux, N | 1 |
| Simon, E | 1 |
| Rod, A | 1 |
| Héron, I | 1 |
| Castera, V | 1 |
| Sentilhes, L | 1 |
| Bretelle, F | 1 |
| Rolland, C | 1 |
| Morin, M | 1 |
| Deruelle, P | 1 |
| De Carne, C | 1 |
| Maillot, F | 1 |
| Beucher, G | 1 |
| Verspyck, E | 1 |
| Desbriere, R | 1 |
| Laboureau, S | 1 |
| Mitanchez, D | 1 |
| Bouyer, J | 1 |
| Mathews, JE | 2 |
| Biswas, B | 1 |
| Samuel, P | 1 |
| Jana, AK | 2 |
| Muliyil, JP | 1 |
| Mathai, M | 1 |
| Myngheer, N | 1 |
| Allegaert, K | 1 |
| Hattersley, A | 1 |
| McDonald, T | 1 |
| Kramer, H | 1 |
| Ashcroft, FM | 1 |
| Verhaeghe, J | 1 |
| Mathieu, C | 1 |
| Casteels, K | 1 |
| Balsells, M | 1 |
| García-Patterson, A | 1 |
| Solà, I | 1 |
| Roqué, M | 1 |
| Gich, I | 1 |
| Corcoy, R | 1 |
| George, A | 1 |
| Sam, D | 1 |
| Beck, M | 1 |
| Benjamin, SJ | 1 |
| Abraham, A | 1 |
| Antonisamy, B | 1 |
| Thomas, N | 1 |
| Glover, AV | 1 |
| Tita, A | 1 |
| Biggio, JR | 1 |
| Harper, LM | 1 |
| Lain, KY | 1 |
| Garabedian, MJ | 1 |
| Daftary, A | 1 |
| Jeyabalan, A | 1 |
| Carles, G | 1 |
| Germain, L | 1 |
| Alassas, N | 1 |
| El Guindi, W | 1 |
| Dallah, F | 1 |
| Daigre, JL | 1 |
| Langer, O | 2 |
| Yogev, Y | 1 |
| Xenakis, EM | 2 |
| Rosenn, B | 1 |
| Bertini, AM | 1 |
| Silva, JC | 1 |
| Taborda, W | 1 |
| Becker, F | 1 |
| Lemos Bebber, FR | 1 |
| Zucco Viesi, JM | 1 |
| Aquim, G | 1 |
| Engel Ribeiro, T | 1 |
| Kahn, BF | 1 |
| Davies, JK | 1 |
| Lynch, AM | 1 |
| Reynolds, RM | 1 |
| Barbour, LA | 1 |
| Scollan-Koliopoulos, M | 1 |
| Guadagno, S | 1 |
| Walker, EA | 1 |
| Ramos, GA | 1 |
| Jacobson, GF | 1 |
| Kirby, RS | 1 |
| Ching, JY | 1 |
| Field, DR | 1 |
| Moretti, ME | 1 |
| Rezvani, M | 1 |
| Koren, G | 1 |
| Nicholson, WK | 1 |
| Wilson, LM | 1 |
| Witkop, CT | 1 |
| Baptiste-Roberts, K | 1 |
| Bennett, WL | 1 |
| Bolen, S | 1 |
| Barone, BB | 1 |
| Golden, SH | 1 |
| Gary, TL | 1 |
| Neale, DM | 1 |
| Bass, EB | 1 |
| Lim, JM | 1 |
| Tayob, Y | 1 |
| O'Brien, PM | 1 |
| Shaw, RW | 1 |
| Conway, DL | 1 |
| Berkus, MD | 1 |
| Gonzales, O | 1 |
| Greene, MF | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparative Studies of Metformin and Insulin on Stereological Studies and Immunohistochemistry of Placenta[NCT04907708] | 156 participants (Actual) | Interventional | 2018-01-01 | Completed | |||
| Multicenter Randomized Trial of Non-inferiority Between Glyburide and Insulin for the Treatment of Gestational Diabetes[NCT01731431] | Phase 3 | 914 participants (Actual) | Interventional | 2012-05-18 | Completed | ||
| Glyburide and Metformin for the Treatment of Gestational Diabetes Mellitus. A Systematic Review and Meta-analysis of Randomized Controlled Trials Comparing These Drugs Either vs Insulin or vs Each Other.[NCT01998113] | 2,509 participants (Actual) | Observational | 2013-03-31 | Completed | |||
| Effect of Metformin on Healthy Live Birth After In-vitro Fertilization in Women With Prediabetes Mellitus: a Multicenter Double-blind Placebo Controlled Randomized Trial[NCT06064669] | 988 participants (Anticipated) | Interventional | 2023-10-01 | Not yet recruiting | |||
| Non-inferiority Between Acarbose and Prandial Insulin for the Treatment of Gestational Diabetes Mellitus: a Randomized Multicenter and Prospective Trial. ACARB-GDM Study.[NCT03380546] | Phase 3 | 341 participants (Actual) | Interventional | 2018-07-04 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 reviews available for glyburide and Fetal Macrosomia
| Article | Year |
|---|---|
Comparative impact of pharmacological treatments for gestational diabetes on neonatal anthropometry independent of maternal glycaemic control: A systematic review and meta-analysis.
Topics: Anthropometry; Birth Weight; Blood Glucose; Diabetes, Gestational; Female; Fetal Macrosomia; Glyburi | 2020 |
Comparative efficacy and safety of oral antidiabetic drugs and insulin in treating gestational diabetes mellitus: An updated PRISMA-compliant network meta-analysis.
Topics: Administration, Oral; Adult; Blood Glucose; Comparative Effectiveness Research; Diabetes, Gestationa | 2017 |
Glibenclamide, metformin, and insulin for the treatment of gestational diabetes: a systematic review and meta-analysis.
Topics: Adult; Birth Weight; Diabetes, Gestational; Female; Fetal Macrosomia; Glyburide; Humans; Hypoglycemi | 2015 |
Glibenclamide, metformin, and insulin for the treatment of gestational diabetes: a systematic review and meta-analysis.
Topics: Adult; Birth Weight; Diabetes, Gestational; Female; Fetal Macrosomia; Glyburide; Humans; Hypoglycemi | 2015 |
Glibenclamide, metformin, and insulin for the treatment of gestational diabetes: a systematic review and meta-analysis.
Topics: Adult; Birth Weight; Diabetes, Gestational; Female; Fetal Macrosomia; Glyburide; Humans; Hypoglycemi | 2015 |
Glibenclamide, metformin, and insulin for the treatment of gestational diabetes: a systematic review and meta-analysis.
Topics: Adult; Birth Weight; Diabetes, Gestational; Female; Fetal Macrosomia; Glyburide; Humans; Hypoglycemi | 2015 |
[Treatment of gestational diabetes with oral hypoglycemic agents].
Topics: Diabetes, Gestational; Female; Fetal Macrosomia; Glucose Tolerance Test; Glyburide; Humans; Hypoglyc | 2010 |
Gestational diabetes management: guidelines to a healthy pregnancy.
Topics: Diabetes Mellitus, Type 2; Diabetes, Gestational; Diet, Diabetic; Estrogens; Exercise; Female; Fetal | 2006 |
Safety of glyburide for gestational diabetes: a meta-analysis of pregnancy outcomes.
Topics: Congenital Abnormalities; Diabetes, Gestational; Female; Fetal Blood; Fetal Macrosomia; Glyburide; H | 2008 |
Therapeutic management, delivery, and postpartum risk assessment and screening in gestational diabetes.
Topics: Birth Weight; Blood Glucose; Cesarean Section; Diabetes, Gestational; Female; Fetal Macrosomia; Glyb | 2008 |
5 trials available for glyburide and Fetal Macrosomia
| Article | Year |
|---|---|
Effect of Glyburide vs Subcutaneous Insulin on Perinatal Complications Among Women With Gestational Diabetes: A Randomized Clinical Trial.
Topics: Administration, Oral; Adult; Blood Glucose; Diabetes, Gestational; Female; Fetal Macrosomia; Glyburi | 2018 |
Comparison of neonatal outcomes in women with gestational diabetes with moderate hyperglycaemia on metformin or glibenclamide--a randomised controlled trial.
Topics: Adult; Birth Injuries; Birth Weight; Diabetes, Gestational; Female; Fetal Macrosomia; Glyburide; Hum | 2015 |
Neonatal adiposity following maternal treatment of gestational diabetes with glyburide compared with insulin.
Topics: Adipose Tissue; Adult; Birth Weight; Body Composition; Body Size; Diabetes, Gestational; Female; Fet | 2009 |
Perinatal outcomes and the use of oral hypoglycemic agents.
Topics: Acarbose; Administration, Oral; Adult; Birth Weight; Blood Glucose; Diabetes, Gestational; Female; F | 2005 |
A comparison of glyburide and insulin in women with gestational diabetes mellitus.
Topics: Adolescent; Adult; Blood Glucose; Congenital Abnormalities; Diabetes, Gestational; Female; Fetal Blo | 2000 |
A comparison of glyburide and insulin in women with gestational diabetes mellitus.
Topics: Adolescent; Adult; Blood Glucose; Congenital Abnormalities; Diabetes, Gestational; Female; Fetal Blo | 2000 |
A comparison of glyburide and insulin in women with gestational diabetes mellitus.
Topics: Adolescent; Adult; Blood Glucose; Congenital Abnormalities; Diabetes, Gestational; Female; Fetal Blo | 2000 |
A comparison of glyburide and insulin in women with gestational diabetes mellitus.
Topics: Adolescent; Adult; Blood Glucose; Congenital Abnormalities; Diabetes, Gestational; Female; Fetal Blo | 2000 |
10 other studies available for glyburide and Fetal Macrosomia
| Article | Year |
|---|---|
Antenatal maternal hypoglycemia in women with gestational diabetes mellitus and neonatal outcomes.
Topics: Diabetes, Gestational; Female; Fetal Macrosomia; Glyburide; Humans; Hypoglycemia; Hypoglycemic Agent | 2022 |
Diabetes treatment in two pregnant women with permanent neonatal diabetes mellitus due to a KCNJ11 mutation.
Topics: Adult; Diabetes Mellitus; Drug Therapy, Combination; Female; Fetal Macrosomia; Glyburide; Glycemic C | 2020 |
Retrospective cohort study comparing neonatal outcomes of women treated with glyburide or insulin in gestational diabetes: a 5-year experience in a South Indian teaching hospital.
Topics: Adult; Birth Weight; Blood Glucose; Diabetes, Gestational; Female; Fetal Macrosomia; Glyburide; Hosp | 2011 |
Fetal macrosomia and neonatal hyperinsulinemic hypoglycemia associated with transplacental transfer of sulfonylurea in a mother with KCNJ11-related neonatal diabetes.
Topics: Adult; Congenital Hyperinsulinism; Diabetes Mellitus; Female; Fetal Macrosomia; Glyburide; Humans; H | 2014 |
Examining the Starting Dose of Glyburide in Gestational Diabetes.
Topics: Adult; Birth Weight; Cesarean Section; Cohort Studies; Diabetes, Gestational; Dystocia; Female; Feta | 2016 |
Insulin and glyburide therapy: dosage, severity level of gestational diabetes, and pregnancy outcome.
Topics: Administration, Oral; Blood Glucose; Diabetes, Gestational; Drug Administration Schedule; Female; Fe | 2005 |
Predictors of glyburide failure in the treatment of gestational diabetes.
Topics: Adult; Cesarean Section; Diabetes, Gestational; Female; Fetal Macrosomia; Glyburide; Humans; Hypogly | 2006 |
Comparison of glyburide and insulin for the management of gestational diabetics with markedly elevated oral glucose challenge test and fasting hyperglycemia.
Topics: Adult; Blood Glucose Self-Monitoring; Combined Modality Therapy; Diabetes, Gestational; Diet, Diabet | 2007 |
A comparison between the pregnancy outcome of women with gestation diabetes treated with glibenclamide and those treated with insulin.
Topics: Birth Weight; Diabetes, Gestational; Female; Fetal Macrosomia; Glyburide; Humans; Hypoglycemic Agent | 1997 |
Oral hypoglycemic drugs for gestational diabetes.
Topics: Blood Glucose; Congenital Abnormalities; Diabetes, Gestational; Female; Fetal Blood; Fetal Macrosomi | 2000 |