glyburide has been researched along with Disease Models, Animal in 188 studies
Glyburide: An antidiabetic sulfonylurea derivative with actions like those of chlorpropamide
glyburide : An N-sulfonylurea that is acetohexamide in which the acetyl group is replaced by a 2-(5-chloro-2-methoxybenzamido)ethyl group.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this study, we investigated the possible beneficial effects of lasmiditan and sumatriptan against post-stroke seizures in mice and explored underlying mechanisms in their effects." | 8.12 | Neuroprotective effects of Lasmiditan and Sumatriptan in an experimental model of post-stroke seizure in mice: Higher effects with concurrent opioid receptors or K ( Amanlou, A; Dehpour, AR; Ejtemaei-Mehr, S; Eslami, F; Ghasemi, M; Rahimi, N; Rashidian, A; Shayan, M; Solaimanian, S, 2022) |
| " Many of these compounds, including olanzapine, cause metabolic side-effects such as impaired glucose tolerance and insulin resistance." | 7.80 | Antidiabetic-drug combination treatment for glucose intolerance in adult female rats treated acutely with olanzapine. ( Asiri, Y; Barr, AM; Boyda, HN; Honer, WG; Lo, R; Pang, CC; Procyshyn, RM; Wang, CK; Wu, C, 2014) |
| "This study investigated the role of K(ATP) channels in morphine-induced antinociception and hepatic oxidative stress in acute and inflammatory pain." | 7.79 | The involvement of K(ATP) channels in morphine-induced antinociception and hepatic oxidative stress in acute and inflammatory pain in rats. ( Afify, EA; Khedr, MM; Nasser, SA; Omar, AG, 2013) |
| "We evaluate the effectiveness of nicorandil on warm ischemia-reperfusion injury of the small intestine in a canine model." | 7.77 | The effect of nicorandil on small intestinal ischemia-reperfusion injury in a canine model. ( Arakawa, K; Matsumoto, K; Oshima, K; Sato, H; Suto, Y; Takeyoshi, I; Yamazaki, H, 2011) |
| "To observe and compare the effect of taurine on contractions of aortic rings isolated from normal (NC) and insulin resistance (IR) Sprague-Dawley rats, and to explore its underlying mechanism(s)." | 7.74 | Effects of taurine on aortic rings isolated from fructose-fed insulin resistance Sprague-Dawley rat are changed. ( Li, J; Liang, Y; Niu, L; Wu, D; Xue, W; Zhang, M, 2008) |
| "The present study was designed to evaluate the effects of a potassium channel opener, nicorandil, and to elucidate its possible mechanism of action in aspirin plus pylorus ligation induced and ethanol-induced gastric ulcers in rats." | 7.71 | Evaluation of the effects of nicorandil on experimentally induced gastric ulcers. ( Goswami, SG; Patel, HM; Santani, DD, 2001) |
| "Hydrogen sulfide (H(2)S) is an endogenous gaseous mediator of mucosal defense with antiinflammatory effects that promote ulcer healing." | 5.35 | Endogenous and exogenous hydrogen sulfide promotes resolution of colitis in rats. ( Dicay, M; Martin, GR; McKnight, W; Vong, L; Wallace, JL, 2009) |
| " In this study, we investigated the possible beneficial effects of lasmiditan and sumatriptan against post-stroke seizures in mice and explored underlying mechanisms in their effects." | 4.12 | Neuroprotective effects of Lasmiditan and Sumatriptan in an experimental model of post-stroke seizure in mice: Higher effects with concurrent opioid receptors or K ( Amanlou, A; Dehpour, AR; Ejtemaei-Mehr, S; Eslami, F; Ghasemi, M; Rahimi, N; Rashidian, A; Shayan, M; Solaimanian, S, 2022) |
| "Empagliflozin (EMPA) is a sodium-glucose transporter 2 (SGLT2) inhibitor that functions as a new-generation glucose-lowering agent and has been proven to be beneficial for patients with cardiovascular diseases." | 4.02 | Characteristics of Ventricular Electrophysiological Substrates in Metabolic Mice Treated with Empagliflozin. ( Chou, TW; Jhuo, SJ; Lai, WT; Lee, KT; Lin, YH; Liu, IH; Tasi, WC; Wu, BN, 2021) |
| " This study was conducted to investigate whether or not triamterene, a K(+)-sparing diuretic, can generate protection against seizures induced by intravenous or intraperitoneal pentylenetetrazole (PTZ) models." | 3.83 | A role for ATP-sensitive potassium channels in the anticonvulsant effects of triamterene in mice. ( Almasirad, A; Barati, S; Ghasemi, M; Moezi, L; Shafaroodi, H, 2016) |
| " Many of these compounds, including olanzapine, cause metabolic side-effects such as impaired glucose tolerance and insulin resistance." | 3.80 | Antidiabetic-drug combination treatment for glucose intolerance in adult female rats treated acutely with olanzapine. ( Asiri, Y; Barr, AM; Boyda, HN; Honer, WG; Lo, R; Pang, CC; Procyshyn, RM; Wang, CK; Wu, C, 2014) |
| "This study investigated the role of K(ATP) channels in morphine-induced antinociception and hepatic oxidative stress in acute and inflammatory pain." | 3.79 | The involvement of K(ATP) channels in morphine-induced antinociception and hepatic oxidative stress in acute and inflammatory pain in rats. ( Afify, EA; Khedr, MM; Nasser, SA; Omar, AG, 2013) |
| " We further show, for the first time in any model of sepsis, that glyburide acts as an anti-inflammatory agent by reducing IL1β secretion accompanied by diminished cellular influx and reduced bacterial dissemination to distant organs." | 3.79 | Glyburide reduces bacterial dissemination in a mouse model of melioidosis. ( Bast, A; Breitbach, K; de Jong, HK; Hoogendijk, AJ; Kager, LM; Koh, GC; Krause, K; Peacock, SJ; Steinmetz, I; van der Poll, T; Weehuizen, TA; Wiersinga, WJ, 2013) |
| " We have previously demonstrated that mesenteric lymphatic pumping was compromised in the guinea pig model of 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced ileitis, corroborating clinical and experimental observations of a dilated and/or obstructed phenotype of these vessels in inflammatory bowel disease." | 3.79 | Involvement of the NO-cGMP-K(ATP) channel pathway in the mesenteric lymphatic pump dysfunction observed in the guinea pig model of TNBS-induced ileitis. ( Mathias, R; von der Weid, PY, 2013) |
| "We evaluate the effectiveness of nicorandil on warm ischemia-reperfusion injury of the small intestine in a canine model." | 3.77 | The effect of nicorandil on small intestinal ischemia-reperfusion injury in a canine model. ( Arakawa, K; Matsumoto, K; Oshima, K; Sato, H; Suto, Y; Takeyoshi, I; Yamazaki, H, 2011) |
| "This study was designed to elucidate the contribution of adenosine A(2A) and A(2B) receptors to coronary reactive hyperemia and downstream K(+) channels involved." | 3.76 | Contribution of adenosine A(2A) and A(2B) receptors to ischemic coronary dilation: role of K(V) and K(ATP) channels. ( Berwick, ZC; Dick, GM; Lynch, B; Payne, GA; Sturek, M; Tune, JD, 2010) |
| "To observe and compare the effect of taurine on contractions of aortic rings isolated from normal (NC) and insulin resistance (IR) Sprague-Dawley rats, and to explore its underlying mechanism(s)." | 3.74 | Effects of taurine on aortic rings isolated from fructose-fed insulin resistance Sprague-Dawley rat are changed. ( Li, J; Liang, Y; Niu, L; Wu, D; Xue, W; Zhang, M, 2008) |
| "The role of K(ATP) channels in the antiarrhythmic effect of Escherichia coli endotoxin-induced nitric oxide synthase (iNOS) was examined in an anesthetised rat model of myocardial ischemia and reperfusion arrhythmia by using glibenclamide (1 mg kg(-1)), nateglinide (10 mg kg(-1)) and repaglinide (0." | 3.74 | Glibenclamide attenuates the antiarrhythmic effect of endotoxin with a mechanism not involving K(ATP) channels. ( Erkent, U; Ertunc, M; Guc, MO; Ilhan, M; Iskit, AB; Onur, R, 2007) |
| "We assessed whether pravastatin attenuates cardiac sympathetic reinnervation after myocardial infarction through the activation of ATP-sensitive K(+) (K(ATP)) channels." | 3.74 | Effect of pravastatin on sympathetic reinnervation in postinfarcted rats. ( Chang, NC; Lee, TM; Lin, MS, 2007) |
| " We examined KATP channel modulation in renal ischemia-reperfusion injury (IRI), using an isolated perfused rat kidney (IPRK) model, in control, IRI, IRI+200 microM diazoxide (a KATP opener), IRI + 10 microM glibenclamide (a KATP blocker) and IRI + 200 microM diazoxide + 10 microM glibenclamide groups." | 3.72 | ATP-dependent K+ channels in renal ischemia reperfusion injury. ( Endre, ZH; Gobé, GC; Rahgozar, M; Willgoss, DA, 2003) |
| "The present study was designed to evaluate the effects of a potassium channel opener, nicorandil, and to elucidate its possible mechanism of action in aspirin plus pylorus ligation induced and ethanol-induced gastric ulcers in rats." | 3.71 | Evaluation of the effects of nicorandil on experimentally induced gastric ulcers. ( Goswami, SG; Patel, HM; Santani, DD, 2001) |
| " This study also investigates the effects of a mild epileptic insult on neuronal death in rat hippocampus after a subsequent, lethal epileptic stress using kainic acid (KA) as a model of epilepsy." | 3.70 | Mutually protective actions of kainic acid epileptic preconditioning and sublethal global ischemia on hippocampal neuronal death: involvement of adenosine A1 receptors and K(ATP) channels. ( Blondeau, N; Heurteaux, C; Lazdunski, M; Plamondon, H, 1999) |
| " This study was designed to determine whether clofilium exhibits antifibrillatory activity in a pinacidil + hypoxia-induced model of ventricular fibrillation (VF) in Langendorff-perfused hearts." | 3.69 | Antifibrillatory effects of clofilium in the rabbit isolated heart. ( Chi, L; Friedrichs, GS; Green, AL; Lucchesi, BR, 1994) |
| "We investigated the effect of ATP-sensitive K+ channel (KATP) openers (pinacidil and cromakalim), and a KATP blocker (glibenclamide) on reperfusion-induced arrhythmias in pentobarbitone-anaesthetized rats." | 3.69 | KATP channel modulators increase survival rate during coronary occlusion-reperfusion in anaesthetized rats. ( Baczkó, I; Leprán, I; Papp, JG, 1997) |
| " Studies were conducted under control conditions and in the presence of four inhibitors of potential mediators of the reactive hyperemia response: the nitric oxide synthase inhibitor NG-nitro-L-arginine methyl ester (30 microM), the adenosine antagonist 8-(p-sulfophenyl)theophylline (50 microM), the K+ cyclic adenosine triphosphate-dependent channel antagonist glibenclamide (10 microM), and the cyclooxygenase inhibitor indomethacin (10 microM)." | 3.69 | Myocardial reactive hyperemia in experimental chronic heart failure: evidence for the role of K+ adenosine triphosphate-dependent channels and cyclooxygenase activity. ( Dumont, L; Fontaine, E; Jasmin, G; Véronneau, M; Viau, S, 1997) |
| "Using a transient middle cerebral artery occlusion (tMCAo) rodent model of stroke, we studied two rat cohorts, one without rt-PA and a second cohort treated with rt-PA." | 1.62 | Continuous Glibenclamide Prevents Hemorrhagic Transformation in a Rodent Model of Severe Ischemia-Reperfusion. ( Igarashi, T; Kimberly, WT; Sastre, C; Wolcott, Z, 2021) |
| "The pathogenesis of idiopathic inflammatory myopathy (IIM) is complex and unclear." | 1.62 | Study of the correlation between the noncanonical pathway of pyroptosis and idiopathic inflammatory myopathy. ( Chai, K; Deng, R; Ma, M, 2021) |
| "CS includes dilated vasculature, marked cardiac hypertrophy, and other cardiovascular abnormalities." | 1.56 | Glibenclamide reverses cardiovascular abnormalities of Cantu syndrome driven by KATP channel overactivity. ( Chalk, R; Halabi, CM; Harter, TM; Huang, Y; Kovacs, A; McClenaghan, C; Nichols, CG; Remedi, MS; van Haaften, G; Yan, Z, 2020) |
| "In the model of neuropathic pain, preventive and therapeutic effects were observed." | 1.51 | Metformin antinociceptive effect in models of nociceptive and neuropathic pain is partially mediated by activation of opioidergic mechanisms. ( Augusto, PSA; Batista, CRA; Braga, AV; Coelho, MM; Costa, SOAM; Dutra, MMGB; Goulart, FA; Machado, RR; Melo, ISF; Morais, MI; Rodrigues, FF, 2019) |
| " The effect of drying conditions on the morphology, moisture content, hardness, dosage uniformity, surface characteristics, and drug release mechanism of glibenclamide from the matrices was systematically investigated." | 1.51 | Controlled release of glibenclamide from monolithic silica subdermal implants produced by the sol-gel process and its use for hyperglycaemia treatment in a murine model. ( Espinosa-Contreras, C; Flores-Cabrera, Y; Hernández-Abad, VJ; Marroquín-Segura, R; Mora-Guevara, JLA; Sánchez-González, EG, 2019) |
| "Glibenclamide may reduce cerebral edema by inhibiting sulfonylurea receptor-1 (Sur1); its effect on diffuse cerebral edema exacerbated by hypotension/resuscitation is unknown." | 1.48 | Glibenclamide Produces Region-Dependent Effects on Cerebral Edema in a Combined Injury Model of Traumatic Brain Injury and Hemorrhagic Shock in Mice. ( Hoshitsuki, K; Jackson, TC; Janesko-Feldman, KL; Jha, RM; Kochanek, PM; Minnigh, MB; Molyneaux, BJ; Park, SY; Poloyac, S; Vagni, VA; Wallisch, JS, 2018) |
| "Successful rat models for preeclampsia were confirmed based on mean arterial pressure, a 24-h protein urine test, and by observing the structure of the kidney by transmission electron microscopy (TEM)." | 1.48 | Role of AKR1C3 in renal injury and glibenclamide is anti-inflammatory in preeclamptic rats. ( Jin, Y; Li, L; Liu, XW; Sun, CJ; Zhang, WY, 2018) |
| "Cerebral edema is one of the major causes of mortality following cardiac arrest (CA) and cardiopulmonary resuscitation (CPR)." | 1.48 | Glibenclamide and Therapeutic Hypothermia Have Comparable Effect on Attenuating Global Cerebral Edema Following Experimental Cardiac Arrest. ( Isaka, Y; Nakamura, T; Nakayama, S; Taguchi, N; Tanaka, M, 2018) |
| "Meanwhile, cerebral edema, as well as neuronal loss, was decreased in several brain areas in the GBC group." | 1.46 | Glibenclamide ameliorates cerebral edema and improves outcomes in a rat model of status epilepticus. ( Gu, Y; Hu, Y; Huang, H; Huang, K; Ji, Z; Lin, Z; Pan, S; Wang, S; Wu, Y; Yang, T, 2017) |
| " All of these efforts led to the identification of compound 11 as a potent and orally bioavailable FFA1 agonist without the risk of hypoglycemia." | 1.43 | Discovery of novel pyrrole-based scaffold as potent and orally bioavailable free fatty acid receptor 1 agonists for the treatment of type 2 diabetes. ( Cai, X; Dai, Y; Fu, M; Huang, W; Li, Z; Pan, M; Qian, H; Shi, W; Su, X, 2016) |
| "Glibenclamide and thymoquinone plasma concentrations were analysed using a sensitive RP-HPLC method, and non-compartmental model pharmacokinetic parameters were calculated." | 1.42 | Effects of Thymoquinone on the Pharmacokinetics and Pharmacodynamics of Glibenclamide in a Rat Model. ( Ahmad, A; Al-Jenoobi, FI; Al-Mohizea, AM; Alkharfy, KM; Khan, RM; Raish, M, 2015) |
| "Metformin promotes irisin release from murine skeletal muscle into blood, independently of AMPK pathway activation." | 1.42 | Metformin promotes irisin release from murine skeletal muscle independently of AMP-activated protein kinase activation. ( Deng, YP; Huang, F; Jiang, GJ; Li, DJ; Lu, WJ; Shen, FM, 2015) |
| "The rat model of bone cancer pain was induced by implanting rat mammary gland carcinoma cells (Walker256) into the tibias." | 1.40 | Role of ATP-sensitive potassium channels in modulating nociception in rat model of bone cancer pain. ( Fan, L; Pan, HL; Ren, J; Tian, Y; Wang, X; Wang, Y; Wu, J; Xia, H; Xu, L; Yang, S; Yao, W; Zhang, C; Zhang, D, 2014) |
| "The citronellal was able to increase the pain threshold in the DA test (p < 0." | 1.39 | Citronellal, a monoterpene present in Java citronella oil, attenuates mechanical nociception response in mice. ( Almeida, JR; Camargo, EA; de Oliveira, AP; de Oliveira, MG; de Santana, MT; De Sousa, DP; Quintans-Júnior, LJ; Santana, DG; Santana, MF, 2013) |
| "Diabetes can exacerbate seizures and worsen seizure-related brain damage." | 1.39 | Pregabalin attenuates excitotoxicity in diabetes. ( Cheng, JT; Huang, CC; Huang, CW; Lai, MC; Tsai, JJ; Wu, SN, 2013) |
| "Treatment with naloxone, L-arginine and glibenclamide reversed the effect of LPEF in glutamate test." | 1.39 | Antinociceptive effect of Lecythis pisonis Camb. (Lecythidaceae) in models of acute pain in mice. ( Almeida, FR; Brandão, MS; Chaves, MH; Ferreira, EL; Lima, DF; Oliveira, JP; Pereira, SS, 2013) |
| "Riluzole is a pleotropic drug that blocks "persistent sodium currents" in neurons, but in SCI, its molecular mechanism of action is uncertain." | 1.38 | Comparative effects of glibenclamide and riluzole in a rat model of severe cervical spinal cord injury. ( Gerzanich, V; Ivanov, A; Ivanova, S; Keledjian, K; Simard, JM; Tsymbalyuk, O, 2012) |
| "Risperidone has been used in some stress disorders and may be potentially protective against stress-induced gastric lesions." | 1.37 | Gastroprotective potential of risperidone, an atypical antipsychotic, against stress and pyloric ligation induced gastric lesions. ( Krishnamurthy, S; Saxena, B; Singh, S, 2011) |
| "Glyburide (GLB) is an oral sulfonylurea, commonly used for the treatment of gestational diabetes mellitus." | 1.36 | Increased glyburide clearance in the pregnant mouse model. ( Hebert, MF; Mao, Q; Unadkat, JD; Zhang, Y; Zhou, L, 2010) |
| "Hydrogen sulfide (H(2)S) is an endogenous gaseous mediator of mucosal defense with antiinflammatory effects that promote ulcer healing." | 1.35 | Endogenous and exogenous hydrogen sulfide promotes resolution of colitis in rats. ( Dicay, M; Martin, GR; McKnight, W; Vong, L; Wallace, JL, 2009) |
| "To create HT model, right middle cerebral artery occlusion (MCAO) was conducted with intraluminal thread technique; 30 min after MCAO, 50 microL arterial blood was injected into the caudate nucleus where the infarction occurred." | 1.35 | Brain damage related to hemorrhagic transformation following cerebral ischemia and the role of K ATP channels. ( Li, LT; Yang, Y; Yin, J; Zhang, XJ, 2008) |
| "10% glycerol solution was able to prevent microvascular alterations due to BCCAO protecting cerebral tissue." | 1.35 | Pial microvascular responses to transient bilateral common carotid artery occlusion: effects of hypertonic glycerol. ( Colantuoni, A; Lapi, D; Marchiafava, PL, 2008) |
| "Cardiac dysfunction during hemorrhagic shock (HS) is associated with myocardial ischemia, during which adenosine triphosphate (ATP)-sensitive potassium (K(ATP)) channels can be activated." | 1.35 | Adenosine triphosphate-sensitive potassium channels prevent extension of myocardial ischemia to subepicardium during hemorrhagic shock. ( Adachi, T; Aikawa, N; Hori, S; Inoue, S; Miyazaki, K; Mori, H; Nakagawa, M; Nakazawa, H; Ogawa, S; Suzuki, M, 2008) |
| "The R6/2 transgenic mouse model of Huntington's disease (HD) develops a progressive neurological phenotype that involves severe motor and cognitive dysfunctions." | 1.33 | Atypical diabetes associated with inclusion formation in the R6/2 mouse model of Huntington's disease is not improved by treatment with hypoglycaemic agents. ( Hunt, MJ; Morton, AJ, 2005) |
| "Cardiac hypertrophy has been demonstrated to decreases the ATP-sensitive potassium channels (K(ATP)), the major protective mechanism following the energy depletion, a common condition seen during the reperfusion after open heart surgery." | 1.32 | Ischemic preconditioning prevents reperfusion heart injury in cardiac hypertrophy by activation of mitochondrial KATP channels. ( Maeda, H; Rajesh, KG; Sasaguri, S; Suzuki, R; Xing, Y, 2004) |
| "The influence of left ventricular hypertrophy (LVH) on the endothelial function of resistance endocardial arteries is not well established." | 1.32 | Loss of endothelial KATP channel-dependent, NO-mediated dilation of endocardial resistance coronary arteries in pigs with left ventricular hypertrophy. ( Gendron, ME; Perrault, LP; Thorin, E, 2004) |
| "Hypercholesterolemia was induced by two weeks of cholesterol-enriched diet." | 1.31 | K(ATP) channel opening is an endogenous mechanism of protection against the no-reflow phenomenon but its function is compromised by hypercholesterolemia. ( Genda, S; Ichikawa, Y; Miki, T; Miura, T; Shimamoto, K, 2002) |
| " The dose-response curve of insulin secretion showed a markedly reduced maximum response, but almost normal glucose sensitivity in NSY islets." | 1.31 | Insulin secretion to glucose as well as nonglucose stimuli is impaired in spontaneously diabetic Nagoya-Shibata-Yasuda mice. ( Babaya, N; Hamada, Y; Ikegami, H; Kawaguchi, Y; Nojima, K; Ogihara, T; Shibata, M; Ueda, H; Yamada, K; Yamato, E, 2001) |
| "Pretreatment with diazoxide (10 mg." | 1.29 | Effects of diazoxide on norepinephrine-induced vasocontraction and ischemic myocardium in rats. ( Ichihara, K; Nakai, T, 1994) |
| "Hemorrhagic shock is associated with early vasomotor paralysis as well as with early derangements in the intracellular metabolic status." | 1.29 | Inhibition of ATP-activated potassium channels exerts pressor effects and improves survival in a rat model of severe hemorrhagic shock. ( Salzman, AL; Szabó, C, 1996) |
| "In both the stunned myocardium model as well as the infarcted myocardium model, the beneficial effects of the potassium channel openers could not be attributed to differences in the traditional determinants of the extent of ischaemia/reperfusion injury; area at risk size, oxygen consumption, or collateral blood flow." | 1.29 | Cardioprotective actions of potassium channel openers. ( Auchampach, JA; Gross, GJ; Maruyama, M, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (1.06) | 18.7374 |
| 1990's | 25 (13.30) | 18.2507 |
| 2000's | 62 (32.98) | 29.6817 |
| 2010's | 80 (42.55) | 24.3611 |
| 2020's | 19 (10.11) | 2.80 |
| Authors | Studies |
|---|---|
| Navarrete-Vazquez, G | 2 |
| Paoli, P | 1 |
| León-Rivera, I | 2 |
| Villalobos-Molina, R | 1 |
| Medina-Franco, JL | 2 |
| Ortiz-Andrade, R | 1 |
| Estrada-Soto, S | 2 |
| Camici, G | 1 |
| Diaz-Coutiño, D | 1 |
| Gallardo-Ortiz, I | 1 |
| Martinez-Mayorga, K | 1 |
| Moreno-Díaz, H | 1 |
| Torres-Gómez, H | 1 |
| Hidalgo-Figueroa, S | 1 |
| Ramírez-Espinosa, JJ | 1 |
| Alarcón-Aguilar, FJ | 1 |
| Almanza-Pérez, JC | 1 |
| Li, Z | 1 |
| Pan, M | 1 |
| Su, X | 1 |
| Dai, Y | 1 |
| Fu, M | 1 |
| Cai, X | 1 |
| Shi, W | 1 |
| Huang, W | 1 |
| Qian, H | 1 |
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Mohammadi, S | 1 |
| Fakhri, S | 1 |
| Mohammadi-Farani, A | 1 |
| Farzaei, MH | 1 |
| Abbaszadeh, F | 1 |
| Ferdowsi, S | 1 |
| Abdolmaleki, A | 1 |
| Asadi, A | 1 |
| Zahri, S | 1 |
| Shayan, M | 1 |
| Eslami, F | 1 |
| Amanlou, A | 1 |
| Solaimanian, S | 1 |
| Rahimi, N | 1 |
| Rashidian, A | 1 |
| Ejtemaei-Mehr, S | 1 |
| Ghasemi, M | 4 |
| Dehpour, AR | 4 |
| Zusman, BE | 1 |
| Wu, Y | 2 |
| Kochanek, PM | 2 |
| Vagni, VE | 1 |
| Janesko-Feldman, K | 1 |
| Gerzanich, V | 11 |
| Simard, JM | 11 |
| Karahalios, K | 1 |
| Mihaljevic, S | 1 |
| Raikwar, S | 1 |
| Rani, A | 1 |
| Rulney, J | 1 |
| Desai, SM | 1 |
| Catapano, J | 1 |
| Jha, RM | 2 |
| Yang, X | 3 |
| Qu, C | 1 |
| Jia, J | 1 |
| Zhan, Y | 1 |
| Esmaeili, MH | 2 |
| Enayati, M | 1 |
| Khabbaz Abkenar, F | 1 |
| Ebrahimian, F | 1 |
| Salari, AA | 2 |
| Jacobson, SM | 1 |
| MacAllister, TW | 1 |
| Geliebter, DM | 1 |
| McClenaghan, C | 1 |
| Huang, Y | 1 |
| Yan, Z | 1 |
| Harter, TM | 1 |
| Halabi, CM | 1 |
| Chalk, R | 1 |
| Kovacs, A | 1 |
| van Haaften, G | 1 |
| Remedi, MS | 1 |
| Nichols, CG | 1 |
| Hirshman, NA | 1 |
| Hughes, FM | 3 |
| Jin, H | 3 |
| Harrison, WT | 1 |
| White, SW | 1 |
| Doan, I | 1 |
| Harper, SN | 1 |
| Leidig, PD | 1 |
| Purves, JT | 3 |
| Wang, Z | 2 |
| Jia, X | 1 |
| Kasabov, KA | 1 |
| Kudryashov, NV | 1 |
| Volkova, AV | 1 |
| Shimshirt, AA | 1 |
| Kalinina, TS | 1 |
| Zhmurenko, LA | 1 |
| Voronina, TA | 1 |
| Wachal, Z | 1 |
| Bombicz, M | 1 |
| Priksz, D | 1 |
| Hegedűs, C | 1 |
| Kovács, D | 1 |
| Szabó, AM | 1 |
| Kiss, R | 1 |
| Németh, J | 1 |
| Juhász, B | 1 |
| Szilvássy, Z | 2 |
| Varga, B | 1 |
| Liu, H | 1 |
| Gu, C | 1 |
| Liu, M | 1 |
| Liu, G | 1 |
| Wang, Y | 3 |
| Ju, YJ | 1 |
| Kim, N | 1 |
| Gee, MS | 1 |
| Jeon, SH | 1 |
| Lee, D | 1 |
| Do, J | 1 |
| Ryu, JS | 1 |
| Lee, JK | 1 |
| Rosado, AF | 1 |
| Rosa, PB | 1 |
| Platt, N | 1 |
| Pierone, BC | 1 |
| Neis, VB | 1 |
| Severo Rodrigues, AL | 1 |
| Kaster, MP | 1 |
| Kaufmann, FN | 1 |
| Igarashi, T | 1 |
| Sastre, C | 1 |
| Wolcott, Z | 1 |
| Kimberly, WT | 1 |
| Qiu, X | 1 |
| Wang, Q | 2 |
| Hou, L | 1 |
| Zhang, C | 2 |
| Zhao, X | 1 |
| Kung, TFC | 1 |
| Wilkinson, CM | 1 |
| Dirks, CA | 1 |
| Jickling, GC | 1 |
| Colbourne, F | 1 |
| Ma, M | 1 |
| Chai, K | 1 |
| Deng, R | 1 |
| Jhuo, SJ | 1 |
| Liu, IH | 1 |
| Tasi, WC | 1 |
| Chou, TW | 1 |
| Lin, YH | 1 |
| Wu, BN | 1 |
| Lee, KT | 1 |
| Lai, WT | 1 |
| Lin, Z | 3 |
| Huang, H | 1 |
| Gu, Y | 3 |
| Huang, K | 3 |
| Hu, Y | 4 |
| Ji, Z | 3 |
| Wang, S | 4 |
| Yang, T | 1 |
| Pan, S | 3 |
| Sexton, SJ | 2 |
| Govada, V | 1 |
| Babik, B | 1 |
| Balogh, AL | 1 |
| Sudy, R | 1 |
| Ivankovitsne-Kiss, O | 1 |
| Fodor, GH | 1 |
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| Onoue, H | 1 |
| Katusic, ZS | 1 |
| Plamondon, H | 1 |
| Blondeau, N | 1 |
| Heurteaux, C | 1 |
| Lazdunski, M | 1 |
| Morita, K | 1 |
| Kamei, J | 1 |
| Kim, CD | 1 |
| Kim, HH | 1 |
| Kim, YK | 1 |
| Kwak, YK | 1 |
| Kim, S | 1 |
| Yoo, S | 1 |
| Hong, KW | 1 |
| Hoyer, S | 1 |
| Lee, SK | 1 |
| Löffler, T | 1 |
| Schliebs, R | 1 |
| Ambalavanan, N | 1 |
| Bulger, A | 1 |
| Ware, J | 1 |
| Philips, J | 1 |
| Patel, HM | 1 |
| Santani, DD | 1 |
| Goswami, SG | 1 |
| Hamada, Y | 1 |
| Ikegami, H | 1 |
| Ueda, H | 1 |
| Kawaguchi, Y | 1 |
| Yamato, E | 1 |
| Nojima, K | 1 |
| Yamada, K | 1 |
| Babaya, N | 1 |
| Shibata, M | 1 |
| Ogihara, T | 1 |
| Shibasaki, T | 1 |
| Uemura, H | 1 |
| Sato, T | 1 |
| Yamaguchi, K | 1 |
| Koseki, H | 1 |
| Iwanaga, T | 1 |
| Nakaya, H | 1 |
| Seino, S | 1 |
| Fukuse, T | 1 |
| Hirata, T | 1 |
| Omasa, M | 1 |
| Wada, H | 1 |
| Valdés, M | 1 |
| Pascual Leone, A | 1 |
| O'Connor, C | 1 |
| Gwilt, M | 1 |
| Henderson, CG | 1 |
| Orme, J | 1 |
| Rourke, JD | 1 |
| Kamijo, T | 1 |
| Tomaru, T | 1 |
| Miwa, A | 1 |
| Nakamura, F | 1 |
| Kido, H | 1 |
| Sugimoto, T | 1 |
| Uchida, Y | 1 |
| Lorch, E | 1 |
| Gey, KF | 1 |
| Sommer, P | 1 |
2 reviews available for glyburide and Disease Models, Animal
| Article | Year |
|---|---|
Found in translation: The rationale behind the early development of glibenclamide in large hemispheric infarction.
Topics: Animals; Brain Edema; Cerebral Infarction; Disease Models, Animal; Glyburide; Humans | 2020 |
Translational potential of preclinical trials of neuroprotection through pharmacotherapy for spinal cord injury.
Topics: Animals; Disease Models, Animal; Glyburide; Humans; Magnesium Sulfate; Minocycline; Neuroprotective | 2012 |
2 trials available for glyburide and Disease Models, Animal
| Article | Year |
|---|---|
Effects of dexmedetomidine and MK-467 on plasma glucose, insulin and glucagon in a glibenclamide-induced canine hypoglycaemia model.
Topics: Adrenergic alpha-2 Receptor Agonists; Anesthesia, Intravenous; Animals; Blood Glucose; Cross-Over St | 2018 |
Levosimendan attenuates pulmonary vascular remodeling.
Topics: Airway Remodeling; Animals; Cardiotonic Agents; Disease Models, Animal; Germany; Glyburide; Hydrazon | 2011 |
184 other studies available for glyburide and Disease Models, Animal
| Article | Year |
|---|---|
Synthesis, in vitro and computational studies of protein tyrosine phosphatase 1B inhibition of a small library of 2-arylsulfonylaminobenzothiazoles with antihyperglycemic activity.
Topics: Animals; Benzothiazoles; Blood Glucose; Computer Simulation; Diabetes Mellitus, Experimental; Diabet | 2009 |
Synthesis, in vitro and in silico studies of a PPARγ and GLUT-4 modulator with hypoglycemic effect.
Topics: Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; Glucose Transporter Type 4; Humans | 2014 |
Discovery of novel pyrrole-based scaffold as potent and orally bioavailable free fatty acid receptor 1 agonists for the treatment of type 2 diabetes.
Topics: Administration, Oral; Animals; Biological Availability; Diabetes Mellitus, Type 2; Disease Models, A | 2016 |
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Astaxanthin engages the l-arginine/NO/cGMP/KATP channel signaling pathway toward antinociceptive effects.
Topics: Analgesics; Animals; Arginine; Cyclic GMP; Disease Models, Animal; Dose-Response Relationship, Drug; | 2021 |
Glibenclamide promoted functional recovery following sciatic nerve injury in male Wistar rats.
Topics: Animals; Disease Models, Animal; Glyburide; Male; Quality of Life; Rats; Rats, Wistar; Recovery of F | 2022 |
Neuroprotective effects of Lasmiditan and Sumatriptan in an experimental model of post-stroke seizure in mice: Higher effects with concurrent opioid receptors or K
Topics: Adenosine Triphosphate; Animals; Anticonvulsants; bcl-2-Associated X Protein; Benzamides; Disease Mo | 2022 |
Precision Effects of Glibenclamide on MRI Endophenotypes in Clinically Relevant Murine Traumatic Brain Injury.
Topics: Animals; Bayes Theorem; Brain Contusion; Brain Edema; Brain Injuries; Brain Injuries, Traumatic; Dis | 2023 |
NLRP3 inflammasome inhibitor glyburide expedites diabetic-induced impaired fracture healing.
Topics: Animals; Bony Callus; Cytokines; Diabetes Complications; Disease Models, Animal; Femur; Fracture Hea | 2019 |
Glibenclamide mitigates cognitive impairment and hippocampal neuroinflammation in rats with type 2 diabetes and sporadic Alzheimer-like disease.
Topics: Alzheimer Disease; Animals; Cognitive Dysfunction; Diabetes Complications; Diabetes Mellitus, Type 2 | 2020 |
Glibenclamide reverses cardiovascular abnormalities of Cantu syndrome driven by KATP channel overactivity.
Topics: Animals; Cardiomegaly; Disease Models, Animal; Gene Knock-In Techniques; Glyburide; Humans; Hypertri | 2020 |
Cyclophosphamide-induced cystitis results in NLRP3-mediated inflammation in the hippocampus and symptoms of depression in rats.
Topics: Affect; Animals; Antidepressive Agents; Behavior, Animal; Blood-Brain Barrier; Caspase 1; Cyclophosp | 2020 |
Neuroprotection of Glibenclamide against Brain Injury after Cardiac Arrest via Modulation of NLRP3 Inflammasome.
Topics: Animals; Brain Injuries; Cardiopulmonary Resuscitation; Disease Models, Animal; Glyburide; Heart Arr | 2019 |
Psychotropic Effects of a New Pyrazolo[C]Pyridine Derivate GIZh-72 are Related to Functional Activity of Atp-Sensitive Potassium Channels.
Topics: Animals; Anti-Anxiety Agents; Blood Glucose; Disease Models, Animal; Dose-Response Relationship, Dru | 2020 |
Retinoprotection by BGP-15, a Hydroximic Acid Derivative, in a Type II Diabetic Rat Model Compared to Glibenclamide, Metformin, and Pioglitazone.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Disease Models, Animal; Ele | 2020 |
NEK7 mediated assembly and activation of NLRP3 inflammasome downstream of potassium efflux in ventilator-induced lung injury.
Topics: Animals; Anti-Inflammatory Agents; Biomechanical Phenomena; Cations, Monovalent; Cell Line; Disease | 2020 |
Glibenclamide modulates microglial function and attenuates Aβ deposition in 5XFAD mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Anti-Inflammatory | 2020 |
Glibenclamide treatment prevents depressive-like behavior and memory impairment induced by chronic unpredictable stress in female mice.
Topics: Animals; Behavior, Animal; Depression; Disease Models, Animal; Female; Glyburide; Hippocampus; Hypog | 2021 |
Continuous Glibenclamide Prevents Hemorrhagic Transformation in a Rodent Model of Severe Ischemia-Reperfusion.
Topics: Animals; Brain Edema; Disease Models, Animal; Fibrinolytic Agents; Glyburide; Infarction, Middle Cer | 2021 |
Inhibition of NLRP3 inflammasome by glibenclamide attenuated dopaminergic neurodegeneration and motor deficits in paraquat and maneb-induced mouse Parkinson's disease model.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Antiparkinson Agents; Disease Models, Animal; Dopam | 2021 |
Glibenclamide does not improve outcome following severe collagenase-induced intracerebral hemorrhage in rats.
Topics: Animals; Behavior, Animal; Blood-Brain Barrier; Brain Edema; Cerebral Hemorrhage; Collagenases; Dise | 2021 |
Study of the correlation between the noncanonical pathway of pyroptosis and idiopathic inflammatory myopathy.
Topics: Animals; Disease Models, Animal; Female; Glyburide; Guinea Pigs; Humans; Mice; Muscle, Skeletal; Myo | 2021 |
Characteristics of Ventricular Electrophysiological Substrates in Metabolic Mice Treated with Empagliflozin.
Topics: Animals; Benzhydryl Compounds; Cardiovascular Diseases; Connexin 43; Connexins; Diet, High-Fat; Dise | 2021 |
Glibenclamide ameliorates cerebral edema and improves outcomes in a rat model of status epilepticus.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Edema; Cognition Disorders; Disease Models, Animal; Gene | 2017 |
Bladder fibrosis during outlet obstruction is triggered through the NLRP3 inflammasome and the production of IL-1β.
Topics: Animals; Autocrine Communication; Cells, Cultured; Disease Models, Animal; Female; Fibrillar Collage | 2017 |
Levosimendan prevents bronchoconstriction and adverse respiratory tissue mechanical changes in rabbits.
Topics: Airway Resistance; Animals; Bronchial Hyperreactivity; Bronchoconstriction; Cardiac Output; Disease | 2017 |
Glibenclamide and Therapeutic Hypothermia Have Comparable Effect on Attenuating Global Cerebral Edema Following Experimental Cardiac Arrest.
Topics: Animals; Brain Edema; Disease Models, Animal; Glyburide; Heart Arrest; Hypoglycemic Agents; Hypother | 2018 |
Anthelminthic activity of glibenclamide on secondary cystic echinococcosis in mice.
Topics: Administration, Oral; Animals; Anthelmintics; Disease Models, Animal; Echinococcosis; Echinococcus g | 2017 |
Antitussive and expectorant activities of licorice and its major compounds.
Topics: Administration, Oral; Ammonia; Animals; Antitussive Agents; Cough; Disease Models, Animal; Dose-Resp | 2018 |
ATP-sensitive potassium-channel inhibitor glibenclamide attenuates HPA axis hyperactivity, depression- and anxiety-related symptoms in a rat model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Anxiety; Corticosterone; Depression; Disease Mode | 2018 |
Role of AKR1C3 in renal injury and glibenclamide is anti-inflammatory in preeclamptic rats.
Topics: Acute Kidney Injury; Aldo-Keto Reductase Family 1 Member C3; Animals; Anti-Inflammatory Agents; Dise | 2018 |
Glibenclamide Produces Region-Dependent Effects on Cerebral Edema in a Combined Injury Model of Traumatic Brain Injury and Hemorrhagic Shock in Mice.
Topics: Animals; Blood Glucose; Brain Edema; Brain Injuries, Traumatic; Disease Models, Animal; Glyburide; H | 2018 |
Neuroprotective potential of glibenclamide is mediated by antioxidant and anti-apoptotic pathways in intracerebral hemorrhage.
Topics: Animals; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Brain; Caspase 3; Cerebral Hemorrhage; | 2018 |
TLR4-MyD88 pathway promotes the imbalanced activation of NLRP3/NLRP6 via caspase-8 stimulation after alkali burn injury.
Topics: Animals; Blotting, Western; Burns, Chemical; Caspase 8; Disease Models, Animal; Eye Injuries; Fluore | 2018 |
Bladder decompensation and reduction in nerve density in a rat model of chronic bladder outlet obstruction are attenuated with the NLRP3 inhibitor glyburide.
Topics: Animals; Anti-Inflammatory Agents; Autonomic Nervous System; Chronic Disease; Cystitis; Disease Mode | 2019 |
Controlled release of glibenclamide from monolithic silica subdermal implants produced by the sol-gel process and its use for hyperglycaemia treatment in a murine model.
Topics: Animals; Delayed-Action Preparations; Disease Models, Animal; Glyburide; Humidity; Hyperglycemia; Im | 2019 |
An analog of glibenclamide selectively enhances autophagic degradation of misfolded α1-antitrypsin Z.
Topics: alpha 1-Antitrypsin; alpha 1-Antitrypsin Deficiency; Animals; Autophagy; Caenorhabditis elegans; Cae | 2019 |
A novel small molecular NLRP3 inflammasome inhibitor alleviates neuroinflammatory response following traumatic brain injury.
Topics: Analysis of Variance; Animals; Brain Injuries, Traumatic; CD11b Antigen; Disease Models, Animal; Dos | 2019 |
Glibenclamide alleviates inflammation in oleic acid model of acute lung injury through NLRP3 inflammasome signaling pathway.
Topics: Acute Lung Injury; Animals; Disease Models, Animal; Glyburide; Inflammasomes; Inflammation; Male; NL | 2019 |
Metformin antinociceptive effect in models of nociceptive and neuropathic pain is partially mediated by activation of opioidergic mechanisms.
Topics: Analgesics; Animals; Disease Models, Animal; Female; Glyburide; Hyperalgesia; Metformin; Mice; Naltr | 2019 |
Acute regional left atrial ischemia causes acceleration of atrial drivers during atrial fibrillation.
Topics: Animals; Atrial Fibrillation; Disease Models, Animal; Electrophysiologic Techniques, Cardiac; Glybur | 2013 |
Activity of nicorandil, a nicotinamide derivative with a nitrate group, in the experimental model of pain induced by formaldehyde in mice.
Topics: Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Formaldehyde; Glyburi | 2013 |
Anti-nociceptive and anti-edematogenic effects of glibenclamide in a model of acute gouty attack in rats.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Dinoprostone; Disease Models, Animal; Glyburide; Gout | 2013 |
Pregabalin attenuates excitotoxicity in diabetes.
Topics: Adenosine Triphosphate; Animals; Anticonvulsants; Blood Glucose; Cell Line; Diabetic Neuropathies; D | 2013 |
Citronellal, a monoterpene present in Java citronella oil, attenuates mechanical nociception response in mice.
Topics: Acyclic Monoterpenes; Aldehydes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclic GMP; Cymbo | 2013 |
MRI evidence that glibenclamide reduces acute lesion expansion in a rat model of spinal cord injury.
Topics: Aging; Animals; Disease Models, Animal; Female; Glyburide; Hemorrhage; Magnetic Resonance Imaging; R | 2013 |
TLR-independent and P2X7-dependent signaling mediate Alu RNA-induced NLRP3 inflammasome activation in geographic atrophy.
Topics: Alu Elements; Animals; Carrier Proteins; Caspase 1; Disease Models, Animal; Geographic Atrophy; Glyb | 2013 |
Antidiabetic-drug combination treatment for glucose intolerance in adult female rats treated acutely with olanzapine.
Topics: Animals; Benzodiazepines; Disease Models, Animal; Drug Therapy, Combination; Fasting; Female; Glucos | 2014 |
Glyburide reduces bacterial dissemination in a mouse model of melioidosis.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Burkholderia pseudomallei; Ceftazidime; Di | 2013 |
Hypothermia improves oral and gastric mucosal oxygenation during hypoxic challenges.
Topics: Animals; Cardiac Output; Cardiotonic Agents; Cross-Over Studies; Disease Models, Animal; Dogs; Femal | 2014 |
Autocrine C-peptide mechanism underlying INS1 beta cell adaptation to oxidative stress.
Topics: Adaptation, Physiological; Animals; Apoptosis; Autocrine Communication; C-Peptide; Cell Line, Tumor; | 2014 |
Role of ATP-sensitive potassium channels in modulating nociception in rat model of bone cancer pain.
Topics: Animals; Bone Neoplasms; Cell Line, Tumor; Disease Models, Animal; Female; Glyburide; Hyperalgesia; | 2014 |
Proarrhythmic effects of aldosterone during myocardial ischemia-reperfusion: implication of the sarcolemmal-KATP channels.
Topics: Action Potentials; Aldosterone; Animals; Benzopyrans; Dihydropyridines; Disease Models, Animal; Fema | 2014 |
Glibenclamide treatment modulates the expression and localization of myosin-IIB in diabetic rat brain.
Topics: Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; Gene Expression Regulation; Glybur | 2014 |
Glibenclamide reduces secondary brain damage after experimental traumatic brain injury.
Topics: Animals; Brain Edema; Brain Injuries; Disease Models, Animal; Electroencephalography; Glyburide; Int | 2014 |
Reversible changes in pancreatic islet structure and function produced by elevated blood glucose.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Disease Models, Animal; Electrophysiology; | 2014 |
Metformin promotes irisin release from murine skeletal muscle independently of AMP-activated protein kinase activation.
Topics: AMP-Activated Protein Kinases; Animals; Biomarkers; Blood Glucose; Cells, Cultured; Diabetes Mellitu | 2015 |
Soluble epoxide hydrolase inhibition improves coronary endothelial function and prevents the development of cardiac alterations in obese insulin-resistant mice.
Topics: Animals; Benzoates; Blood Glucose; Coronary Vessels; Disease Models, Animal; Dose-Response Relations | 2015 |
The beneficial effects of acute hypercapnia on microcirculatory oxygenation in an animal model of sepsis are independent of K(+)ATP channels.
Topics: Adenosine Triphosphate; Animals; Colon; Cytokines; Disease Models, Animal; Glyburide; Hemodynamics; | 2015 |
Glibenclamide Improves Survival and Neurologic Outcome After Cardiac Arrest in Rats.
Topics: Animals; Brain; Chemokine CCL2; Disease Models, Animal; Glyburide; Heart Arrest; Hemodynamics; Male; | 2015 |
Antidiabetic Effects of Aqueous Infusions of Artemisia herba-alba and Ajuga iva in Alloxan-Induced Diabetic Rats.
Topics: Ajuga; Alloxan; Animals; Apigenin; Artemisia; Blood Glucose; Chlorogenic Acid; Diabetes Mellitus, Ex | 2015 |
A Direct Comparison of Three Clinically Relevant Treatments in a Rat Model of Cervical Spinal Cord Injury.
Topics: Animals; Behavior, Animal; Cervical Cord; Disease Models, Animal; Female; Glyburide; Hypoglycemic Ag | 2015 |
Effects of Thymoquinone on the Pharmacokinetics and Pharmacodynamics of Glibenclamide in a Rat Model.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzoquinones; Blood Glucose; Cytochrome P-450 CYP3A; Cytoch | 2015 |
ATP sensitive K(+) channels are critical for maintaining myocardial perfusion and high energy phosphates in the failing heart.
Topics: Adenosine Triphosphate; Animals; Coronary Circulation; Disease Models, Animal; Dogs; Glyburide; Hear | 2016 |
A role for ATP-sensitive potassium channels in the anticonvulsant effects of triamterene in mice.
Topics: Analysis of Variance; Animals; Anticonvulsants; Convulsants; Diazoxide; Disease Models, Animal; Dose | 2016 |
Glibenclamide Attenuates Blood-Brain Barrier Disruption in Adult Mice after Traumatic Brain Injury.
Topics: Animals; Apoptosis; Blood-Brain Barrier; Brain Injuries, Traumatic; Disease Models, Animal; Glyburid | 2017 |
Glibenclamide Is Comparable to Target Temperature Management in Improving Survival and Neurological Outcome After Asphyxial Cardiac Arrest in Rats.
Topics: Animals; Asphyxia; Cardiopulmonary Resuscitation; Disease Models, Animal; Glyburide; Heart Arrest; H | 2016 |
Gastroprotective and ulcer healing effects of hydroethanolic extract of leaves of Caryocar coriaceum: Mechanisms involved in the gastroprotective activity.
Topics: Animals; Antioxidants; Capsaicin; Chromatography, High Pressure Liquid; Chronic Disease; Disease Mod | 2017 |
NLRP3 (Nucleotide Oligomerization Domain-Like Receptor Family, Pyrin Domain Containing 3)-Caspase-1 Inflammasome Degrades Contractile Proteins: Implications for Aortic Biomechanical Dysfunction and Aneurysm and Dissection Formation.
Topics: Aged; Angiotensin II; Animals; Aorta, Abdominal; Aorta, Thoracic; Aortic Aneurysm, Abdominal; Aortic | 2017 |
Effects of taurine on aortic rings isolated from fructose-fed insulin resistance Sprague-Dawley rat are changed.
Topics: 4-Aminopyridine; Acetylcholine; Administration, Oral; Animals; Aorta; Blood Glucose; Blood Pressure; | 2008 |
Brain damage related to hemorrhagic transformation following cerebral ischemia and the role of K ATP channels.
Topics: Adenosine Triphosphatases; Animals; Brain; Brain Edema; Brain Infarction; Brain Ischemia; Cerebral H | 2008 |
Oral glyburide, but not glimepiride, blocks the infarct-size limiting effects of pioglitazone.
Topics: Administration, Oral; Animals; Body Weight; Coronary Vessels; Data Interpretation, Statistical; Deca | 2008 |
Carvedilol reduces myocardial no-reflow by decreasing endothelin-1 via activation of the ATP-sensitive K+ channel.
Topics: Animals; Antihypertensive Agents; Carbazoles; Carvedilol; Disease Models, Animal; Endothelin-1; Glyb | 2008 |
Endogenous and exogenous hydrogen sulfide promotes resolution of colitis in rats.
Topics: Analysis of Variance; Animals; Biomarkers; Biopsy, Needle; Colitis; Cyclooxygenase 1; Cyclooxygenase | 2009 |
Key role of sulfonylurea receptor 1 in progressive secondary hemorrhage after brain contusion.
Topics: Animals; ATP-Binding Cassette Transporters; Blood-Brain Barrier; Brain; Brain Hemorrhage, Traumatic; | 2009 |
ATP-sensitive potassium channels contribute to the time-dependent alteration in the pentylenetetrazole-induced seizure threshold in diabetic mice.
Topics: Analysis of Variance; Animals; Blood Glucose; Body Weight; Cromakalim; Diabetes Mellitus, Experiment | 2010 |
Gastroprotective effect of barbatusin and 3-beta-hydroxy-3-deoxibarbatusin, quinonoid diterpenes isolated from Plectranthus grandis, in ethanol-induced gastric lesions in mice.
Topics: Acetylcysteine; Animals; Anti-Ulcer Agents; Antioxidants; Capsaicin; Disease Models, Animal; Diterpe | 2010 |
Glibenclamide is superior to decompressive craniectomy in a rat model of malignant stroke.
Topics: Animals; Decompressive Craniectomy; Disease Models, Animal; Glyburide; Male; Rats; Rats, Wistar; Str | 2010 |
Effects of antiallergic herbal agents on cystic fibrosis transmembrane conductance regulator in nasal mucosal epithelia of allergic rhinitis rabbits.
Topics: Animals; Cells, Cultured; Chemokine CCL2; Chemokine CCL5; Cystic Fibrosis Transmembrane Conductance | 2009 |
Brief suppression of Abcc8 prevents autodestruction of spinal cord after trauma.
Topics: Animals; ATP-Binding Cassette Transporters; Disease Models, Animal; Gene Expression Regulation; Glyb | 2010 |
The nephroprotective effects of pioglitazone and glibenclamide against gentamicin-induced nephrotoxicity in rats: a comparative study.
Topics: Animals; Antioxidants; Creatinine; Disease Models, Animal; Gentamicins; Glyburide; Kidney Diseases; | 2010 |
SRMS142-based solid lipid microparticles: application in oral delivery of glibenclamide to diabetic rats.
Topics: Administration, Oral; Animals; Ascorbic Acid; Blood Glucose; Calorimetry, Differential Scanning; Che | 2010 |
Increased glyburide clearance in the pregnant mouse model.
Topics: Animals; Disease Models, Animal; Female; Glyburide; Hypoglycemic Agents; Mice; Pregnancy | 2010 |
Study of the effect of inhibiting galanin in Alzheimer's disease induced in rats.
Topics: Administration, Oral; Alzheimer Disease; Amyloid beta-Peptides; Animals; Avoidance Learning; Brain; | 2010 |
Contribution of adenosine A(2A) and A(2B) receptors to ischemic coronary dilation: role of K(V) and K(ATP) channels.
Topics: 4-Aminopyridine; Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Anima | 2010 |
Glibenclamide reduces hippocampal injury and preserves rapid spatial learning in a model of traumatic brain injury.
Topics: Animals; Brain Injuries; Disease Models, Animal; Glyburide; Hippocampus; Maze Learning; Rats; Rats, | 2010 |
Gastroprotective potential of risperidone, an atypical antipsychotic, against stress and pyloric ligation induced gastric lesions.
Topics: Animals; Antipsychotic Agents; Capillary Permeability; Dinoprostone; Disease Models, Animal; Dopamin | 2011 |
Sitagliptin lowers glucagon and improves glucose tolerance in prediabetic obese SHROB rats.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Disease Models, Animal; Feeding Beha | 2011 |
The effect of nicorandil on small intestinal ischemia-reperfusion injury in a canine model.
Topics: Animals; Disease Models, Animal; Dogs; Female; Glyburide; Intestine, Small; KATP Channels; Male; Mes | 2011 |
Metformin: an effective attenuator of risperidone-induced insulin resistance hyperglycemia and dyslipidemia in rats.
Topics: Animals; Antipsychotic Agents; Blood Glucose; Disease Models, Animal; Dyslipidemias; Glyburide; Huma | 2011 |
Sildenafil attenuates TNBS-induced colitis in rats: possible involvement of cGMP and KATP channels.
Topics: Animals; Colitis; Cyclic GMP; Disease Models, Animal; Glyburide; KATP Channels; Male; Phosphodiester | 2012 |
Anti-tussive and bronchodilator mechanisms of action for the enaminone E121.
Topics: Administration, Inhalation; Adrenergic beta-Antagonists; Airway Obstruction; Aniline Compounds; Anim | 2011 |
Impaired blood pressure recovery to hemorrhage in obese Zucker rats with orthopedic trauma.
Topics: Animals; Arterioles; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Femor | 2012 |
Vulnerability of the retinal microvasculature to hypoxia: role of polyamine-regulated K(ATP) channels.
Topics: Animals; Apoptosis; Disease Models, Animal; Eflornithine; Glyburide; Hypoxia; Ion Transport; KATP Ch | 2011 |
Sequential activation of hypoxia-inducible factor 1 and specificity protein 1 is required for hypoxia-induced transcriptional stimulation of Abcc8.
Topics: Action Potentials; Animals; ATP-Binding Cassette Transporters; Binding Sites; Brain; Calcium Channel | 2012 |
Comparative effects of glibenclamide and riluzole in a rat model of severe cervical spinal cord injury.
Topics: Action Potentials; Analysis of Variance; Animals; Calcimycin; Calcium; Calcium Ionophores; Capillari | 2012 |
N-palmitoyl-ethanolamine (PEA) induces peripheral antinociceptive effect by ATP-sensitive K+-channel activation.
Topics: Amides; Analgesics; Animals; Dequalinium; Dinoprostone; Disease Models, Animal; Dose-Response Relati | 2012 |
The involvement of K(ATP) channels in morphine-induced antinociception and hepatic oxidative stress in acute and inflammatory pain in rats.
Topics: Acute Pain; Analgesics, Opioid; Animals; Chemical and Drug Induced Liver Injury; Diazoxide; Disease | 2013 |
Activation of glibenclamide-sensitive ATP-sensitive K+ channels during β-adrenergically induced metabolic stress produces a substrate for atrial tachyarrhythmia.
Topics: Adrenergic beta-Agonists; Animals; Disease Models, Animal; Electrophysiologic Techniques, Cardiac; G | 2012 |
Protective effect of Na(+)/Ca (2+) exchange blocker KB-R7943 on myocardial ischemia-reperfusion injury in hypercholesterolemic rats.
Topics: Animals; Anti-Arrhythmia Agents; Apoptosis; Diet, High-Fat; Disease Models, Animal; Glyburide; Hemod | 2013 |
Involvement of the NO-cGMP-K(ATP) channel pathway in the mesenteric lymphatic pump dysfunction observed in the guinea pig model of TNBS-induced ileitis.
Topics: Animals; ATP-Binding Cassette Transporters; Disease Models, Animal; Enzyme Inhibitors; Glyburide; Gu | 2013 |
Antinociceptive effect of Lecythis pisonis Camb. (Lecythidaceae) in models of acute pain in mice.
Topics: Acetic Acid; Acute Pain; Analgesics; Animals; Arginine; Behavior, Animal; Capsaicin; Disease Models, | 2013 |
New approach to treatment of shock--restitution of vasoreactivity.
Topics: Animals; Blood Pressure; Dimethyl Sulfoxide; Disease Models, Animal; Dopamine; Glyburide; Hemodynami | 2002 |
K(ATP) channel opening is an endogenous mechanism of protection against the no-reflow phenomenon but its function is compromised by hypercholesterolemia.
Topics: Adenosine Triphosphate; Analysis of Variance; Animals; Chronic Disease; Coronary Circulation; Diseas | 2002 |
Impact of hypercholesterolemia on acidosis-induced coronary microvascular dilation.
Topics: Acidosis; Animals; Anti-Arrhythmia Agents; Arterioles; Coronary Vessels; Dilatation, Pathologic; Dis | 2003 |
Isoflurane preconditioning reduces purkinje cell death in an in vitro model of rat cerebellar ischemia.
Topics: Amino Acid Transport System X-AG; Anesthetics, Inhalation; Animals; Aspartic Acid; Brain Ischemia; C | 2003 |
Activation of peripheral delta opioid receptors eliminates cardiac electrical instability in a rat model of post-infarction cardiosclerosis via mitochondrial ATP-dependent K+ channels.
Topics: Adenosine Triphosphate; Analgesics, Opioid; Animals; Decanoic Acids; Disease Models, Animal; Drug An | 2003 |
Hypoglycaemic effect of water extracts of Aegle marmelos fruits in streptozotocin diabetic rats.
Topics: Administration, Oral; Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Disease | 2003 |
Antihyperglycemic effects of three extracts from Momordica charantia.
Topics: Alloxan; Animal Structures; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Di | 2003 |
Effect of the sarcolemmal K(ATP) channel blocker HMR1098 on arrhythmias induced by programmed electrical stimulation in canine old myocardial infarction model: comparison with glibenclamide.
Topics: Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Benzamides; Disease Models, Animal; Dogs; Ele | 2003 |
ATP-dependent K+ channels in renal ischemia reperfusion injury.
Topics: Acute Kidney Injury; Adenosine Triphosphate; Animals; Cromakalim; Diazoxide; Disease Models, Animal; | 2003 |
Electro-acupuncture preconditioning abrogates the elevation of c-Fos and c-Jun expression in neonatal hypoxic-ischemic rat brains induced by glibenclamide, an ATP-sensitive potassium channel blocker.
Topics: Animals; Animals, Newborn; Antihypertensive Agents; Blotting, Western; Brain; Diazoxide; Disease Mod | 2004 |
Changes in the vascular beta-adrenoceptor-activated signalling pathway in 2Kidney-1Clip hypertensive rats.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Aorta, Thoracic; Caffeine; Calcium-Transporting ATP | 2004 |
Simvastatin-induced myocardial protection against ischemia-reperfusion injury is mediated by activation of ATP-sensitive K+ channels.
Topics: Animals; Anti-Arrhythmia Agents; ATP-Binding Cassette Transporters; Collateral Circulation; Disease | 2004 |
Ischemic preconditioning prevents reperfusion heart injury in cardiac hypertrophy by activation of mitochondrial KATP channels.
Topics: Adenosine Triphosphate; Animals; Cardiomegaly; Decanoic Acids; Disease Models, Animal; Glyburide; He | 2004 |
Loss of endothelial KATP channel-dependent, NO-mediated dilation of endocardial resistance coronary arteries in pigs with left ventricular hypertrophy.
Topics: Adenosine Triphosphate; Animals; Bradykinin; Brimonidine Tartrate; Canada; Charybdotoxin; Coronary V | 2004 |
Altered vascular reactivity and KATP channel currents in vascular smooth muscle cells from deoxycorticosterone acetate (DOCA)-salt hypertensive rats.
Topics: Adenosine Triphosphate; Animals; Aorta, Thoracic; Blood Pressure; Canada; Cromakalim; Desoxycorticos | 2004 |
Modulatory effects of Aloe vera leaf gel extract on oxidative stress in rats treated with streptozotocin.
Topics: Alkaloids; Aloe; Animals; Anthraquinones; Blood Glucose; Carotenoids; Diabetes Mellitus, Experimenta | 2005 |
Hypoglycaemic and antidiabetic activity of acetonic extract of Vernonia colorata leaves in normoglycaemic and alloxan-induced diabetic rats.
Topics: Acetone; Administration, Oral; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Disease Mode | 2005 |
[Antidiabetic activity of Zizyphus mauritiana Lam (Rhamnaceae)].
Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Disease Models, Animal; Dose-Respo | 2000 |
[Neuron-protective effect of ischemic preconditioning in a rabbit reperfusion model following spinal ischemia].
Topics: Animals; Disease Models, Animal; Glyburide; Ischemic Preconditioning; Male; Neurons; Nicorandil; Pot | 2005 |
The ATP-sensitive potassium channel blocker glibenclamide prevents renal ischemia/reperfusion injury in rats.
Topics: Adenosine Triphosphate; Animals; Cytokines; Diazoxide; Disease Models, Animal; Glyburide; Interleuki | 2005 |
Antinociceptive effect of leaf essential oil from Croton sonderianus in mice.
Topics: Acetic Acid; Analgesics; Animals; Behavior, Animal; Capsaicin; Croton; Disease Models, Animal; Dose- | 2005 |
Atypical diabetes associated with inclusion formation in the R6/2 mouse model of Huntington's disease is not improved by treatment with hypoglycaemic agents.
Topics: Administration, Oral; Animals; Behavior, Animal; Diabetes Mellitus; Disease Models, Animal; Exocytos | 2005 |
The third gas: H2S regulates perfusion pressure in both the isolated and perfused normal rat liver and in cirrhosis.
Topics: Animals; Base Sequence; Carbon Tetrachloride Poisoning; Cystathionine gamma-Lyase; Disease Models, A | 2005 |
Newly expressed SUR1-regulated NC(Ca-ATP) channel mediates cerebral edema after ischemic stroke.
Topics: Adenosine Triphosphate; Animals; Astrocytes; ATP-Binding Cassette Transporters; Brain Edema; Brain I | 2006 |
Antidiabetic and renoprotective effects of the chloroform extract of Terminalia chebula Retz. seeds in streptozotocin-induced diabetic rats.
Topics: Animals; Blood Glucose; Chloroform; Diabetes Mellitus, Experimental; Disease Models, Animal; Dose-Re | 2006 |
Glibenclamide attenuates the antiarrhythmic effect of endotoxin with a mechanism not involving K(ATP) channels.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Blood Pressure; Carbamates | 2007 |
Antispasmodic effects of Rooibos tea (Aspalathus linearis) is mediated predominantly through K+ -channel activation.
Topics: Animals; Apigenin; Aspalathus; Beverages; Diarrhea; Disease Models, Animal; Dose-Response Relationsh | 2006 |
Selective bronchodilatory effect of Rooibos tea (Aspalathus linearis) and its flavonoid, chrysoeriol.
Topics: Animals; Antihypertensive Agents; Aorta; Aspalathus; Bronchodilator Agents; Disease Models, Animal; | 2006 |
Acute inflammation alters bicarbonate transport in mouse ileum.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Acute Disease; Adenylyl Cyclases; Animals; Antibod | 2007 |
SCH 79797, a selective PAR1 antagonist, limits myocardial ischemia/reperfusion injury in rat hearts.
Topics: Androstadienes; Animals; Cardiotonic Agents; Disease Models, Animal; Dose-Response Relationship, Dru | 2007 |
Effect of K+ATP channel and adenosine receptor blockade during rest and exercise in congestive heart failure.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Blood Flow Velocity; Cardiac Pacing, Artifi | 2007 |
Ischemic postconditioning reduces infarct size by activation of A1 receptors and K+(ATP) channels in both normal and hypercholesterolemic rabbits.
Topics: Adenosine A1 Receptor Antagonists; Analysis of Variance; Animals; Anti-Arrhythmia Agents; Coronary C | 2007 |
Role of ATP-sensitive potassium channels in the biphasic effects of morphine on pentylenetetrazole-induced seizure threshold in mice.
Topics: Adenosine Triphosphate; Animals; Behavior, Animal; Blood Glucose; Cromakalim; Disease Models, Animal | 2007 |
Chronic sodium hydrosulfide treatment decreases medial thickening of intramyocardial coronary arterioles, interstitial fibrosis, and ROS production in spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Chemical Analysis; Blood Pressure; Cardiomegaly; Cardiotonic | 2007 |
Endothelial sulfonylurea receptor 1-regulated NC Ca-ATP channels mediate progressive hemorrhagic necrosis following spinal cord injury.
Topics: Animals; ATP-Binding Cassette Transporters; Behavior, Animal; Calcium Channels; Capillaries; Cells, | 2007 |
COX-2-dependent and potentially cardioprotective effects of negative inotropic substances released after ischemia.
Topics: Adenosine Triphosphate; Animals; Calcium Signaling; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenas | 2007 |
Cardioprotection induced by hydrogen sulfide preconditioning involves activation of ERK and PI3K/Akt pathways.
Topics: Animals; Benzophenanthridines; Cardiotonic Agents; Cell Survival; Chromones; Disease Models, Animal; | 2008 |
Effect of pravastatin on sympathetic reinnervation in postinfarcted rats.
Topics: Animals; Blotting, Western; Cardiac Pacing, Artificial; Coronary Vessels; Disease Models, Animal; GA | 2007 |
Acute antihypertensive action of Tempol in the spontaneously hypertensive rat.
Topics: Amitrole; Animals; Antihypertensive Agents; Blood Pressure; Buthionine Sulfoximine; Catalase; Cromak | 2007 |
Pial microvascular responses to transient bilateral common carotid artery occlusion: effects of hypertonic glycerol.
Topics: Animals; Blood Flow Velocity; Capillary Permeability; Carotid Artery, Common; Carotid Stenosis; Cell | 2008 |
Intravenous nicorandil preserves endothelial junctions by decreasing endothelin-1 via activation of ATP-sensitive K+ channel.
Topics: Animals; Antigens, CD; Cadherins; Coronary Vessels; Disease Models, Animal; Endothelial Cells; Endot | 2007 |
Hyperoxia confers myocardial protection in mechanically ventilated rats through the generation of free radicals and opening of mitochondrial ATP-sensitive potassium channels.
Topics: Acetylcysteine; Animals; Blood Pressure; Coronary Circulation; Decanoic Acids; Disease Models, Anima | 2008 |
Role of the NO/cGMP/K(ATP) pathway in the protective effects of sildenafil against ethanol-induced gastric damage in rats.
Topics: Animals; Arginine; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Diazoxide; Disease Mode | 2008 |
Adenosine triphosphate-sensitive potassium channels prevent extension of myocardial ischemia to subepicardium during hemorrhagic shock.
Topics: Animals; Coronary Circulation; Disease Models, Animal; Dogs; Glyburide; KATP Channels; Myocardial Is | 2008 |
Effect of pressure overload on cardioprotection of mitochondrial KATP channels and GSK-3beta: interaction with the MPT pore.
Topics: Animals; Cardiotonic Agents; Cyclosporine; Diazoxide; Disease Models, Animal; Glyburide; Glycogen Sy | 2008 |
KR-31762, a novel KATP channel opener, exerts cardioprotective effects by opening SarcKATP channels in rat models of ischemia/reperfusion-induced heart injury.
Topics: Animals; Aorta; Benzopyrans; Cardiotonic Agents; Decanoic Acids; Disease Models, Animal; Dose-Respon | 2008 |
Ventricular overdrive pacing-induced preconditioning and no-flow ischemia-induced preconditioning in isolated working rat hearts.
Topics: Animals; Benzopyrans; Blood Pressure; Cardiac Pacing, Artificial; Coronary Circulation; Cromakalim; | 1995 |
Endothelinb receptor agonists produce pulmonary vasodilation in intact newborn lambs with pulmonary hypertension.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Animals, Newborn; Argin | 1995 |
Antifibrillatory effects of clofilium in the rabbit isolated heart.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Decanoic Acids; Disease Models, Animal; Glyburid | 1994 |
Blockade of ATP-sensitive potassium channels by 5-hydroxydecanoate suppresses monophasic action potential shortening during regional myocardial ischemia.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bl | 1994 |
Effects of diazoxide on norepinephrine-induced vasocontraction and ischemic myocardium in rats.
Topics: Analysis of Variance; Animals; Aorta, Thoracic; Calcium; Diazoxide; Disease Models, Animal; Dose-Res | 1994 |
The ATP-dependent potassium channel: an endogenous cardioprotective mechanism.
Topics: Acetylcholine; Adenosine; Animals; Anti-Arrhythmia Agents; Coronary Disease; Decanoic Acids; Disease | 1994 |
Enhancement of ischemic myocardial metabolic derangement by glibenclamide.
Topics: Adenosine Monophosphate; Adenosine Triphosphate; Animals; Blood Glucose; Blood Pressure; Disease Mod | 1994 |
Cardioprotective actions of potassium channel openers.
Topics: Animals; Benzopyrans; Dihydropyridines; Disease Models, Animal; Dogs; Female; Glyburide; Male; Myoca | 1994 |
Protection from ischaemic-reperfusion injury with adenosine pretreatment is reversed by inhibition of ATP sensitive potassium channels.
Topics: Adenosine; Adenosine Triphosphate; Animals; Disease Models, Animal; Dose-Response Relationship, Drug | 1993 |
Glibenclamide does not abolish the protective effect of preconditioning on stunning in the isolated perfused rat heart.
Topics: Animals; Disease Models, Animal; Glyburide; Hydrogen-Ion Concentration; Magnetic Resonance Spectrosc | 1993 |
Ischaemic preconditioning delays ischaemia induced cellular electrical uncoupling in rabbit myocardium by activation of ATP sensitive potassium channels.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Culture Techniques; Disease Models, Animal; Fema | 1993 |
Endothelin-1-induced reduction of myocardial infarct size by activation of ATP-sensitive potassium channels in a rabbit model of myocardial ischaemia and reperfusion.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Arterial Occlusive Diseases; Blood Pressure | 1995 |
Inhibition of ATP-activated potassium channels exerts pressor effects and improves survival in a rat model of severe hemorrhagic shock.
Topics: Animals; ATP-Binding Cassette Transporters; Blood Pressure; Disease Models, Animal; Glyburide; Heart | 1996 |
Myocardial protection in the acutely injured heart: hyperpolarizing versus depolarizing hypothermic cardioplegia.
Topics: Animals; Cardioplegic Solutions; Coronary Circulation; Disease Models, Animal; Female; Glucose; Glyb | 1997 |
KATP channel modulators increase survival rate during coronary occlusion-reperfusion in anaesthetized rats.
Topics: Action Potentials; Adenosine Triphosphate; Analysis of Variance; Animals; Anti-Arrhythmia Agents; Ar | 1997 |
[Protection afforded by a novel K channel opener (Y-26763), against glycerol-induced acute renal failure (ARF) in rats].
Topics: Acute Kidney Injury; Animals; Benzopyrans; Disease Models, Animal; Glyburide; Glycerol; Male; Potass | 1997 |
Myocardial reactive hyperemia in experimental chronic heart failure: evidence for the role of K+ adenosine triphosphate-dependent channels and cyclooxygenase activity.
Topics: Animals; Cardiac Output, Low; Chronic Disease; Coronary Circulation; Cricetinae; Disease Models, Ani | 1997 |
Role of impaired cAMP and calcium-sensitive K+ channel function in altered cerebral hemodynamics following brain injury.
Topics: Animals; Brain; Brain Injuries; Calcium; Cyclic AMP; Disease Models, Animal; Female; Glyburide; Hemo | 1997 |
Microvascular permeability with sulfonylureas in normal and diabetic hamsters.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Capillary Permeability; Cricetinae; Dextrans; D | 1997 |
In vitro and in vivo vasodilating effects of KRN4884, Ki1769 and Ki3005, pyridinecarboxamidine derivatives.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Blood Pressure; Disease Models, Animal; Dose-Resp | 1997 |
Temporal relation of ATP-sensitive potassium-channel activation and contractility before cardioplegia.
Topics: Adenosine Triphosphate; Adrenergic beta-Agonists; Animals; Cardioplegic Solutions; Cardiotonic Agent | 1998 |
The effect of subarachnoid hemorrhage on mechanisms of vasodilation mediated by cyclic adenosine monophosphate.
Topics: 4-Aminopyridine; Adenylyl Cyclases; Animals; Basilar Artery; Charybdotoxin; Colforsin; Cyclic AMP; D | 1998 |
Mutually protective actions of kainic acid epileptic preconditioning and sublethal global ischemia on hippocampal neuronal death: involvement of adenosine A1 receptors and K(ATP) channels.
Topics: Animals; Disease Models, Animal; DNA Fragmentation; Epilepsy; Glyburide; Hippocampus; In Situ Nick-E | 1999 |
Involvement of ATP-sensitive K(+) channels in the anti-tussive effect of moguisteine.
Topics: Animals; Antitussive Agents; ATP-Binding Cassette Transporters; Cough; Disease Models, Animal; Drug | 2000 |
Antiangiogenic effect of KR31372 in rat sponge implant model.
Topics: Angiogenesis Inhibitors; Angiotensin II; Animals; Benzopyrans; Disease Models, Animal; Drug Interact | 2001 |
Inhibition of the neuronal insulin receptor. An in vivo model for sporadic Alzheimer disease?
Topics: Alzheimer Disease; Animals; ATP-Binding Cassette Transporters; Autoradiography; Brain; Cerebral Vent | 2000 |
Hemodynamic effects of levcromakalim in neonatal porcine pulmonary hypertension.
Topics: Animals; Animals, Newborn; Blood Pressure; Cromakalim; Disease Models, Animal; Glyburide; Hemodynami | 2001 |
Evaluation of the effects of nicorandil on experimentally induced gastric ulcers.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Cimetidine; Disease Models, Animal; Dose-Response Relationship, | 2001 |
Insulin secretion to glucose as well as nonglucose stimuli is impaired in spontaneously diabetic Nagoya-Shibata-Yasuda mice.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2001 |
Mouse model of Prinzmetal angina by disruption of the inward rectifier Kir6.1.
Topics: Angina Pectoris, Variant; Animals; Aorta, Thoracic; Blood Pressure; Coronary Vessels; Disease Models | 2002 |
Effect of adenosine triphosphate-sensitive potassium channel openers on lung preservation.
Topics: Adenosine Triphosphate; Animals; Disease Models, Animal; Glyburide; Hypertension, Pulmonary; Lung; P | 2002 |
[Relation of uric acid and arteriosclerosis on an experimental model of chickens fed with eggs. Influence of insulin and oral antidiabetics (glibenclamide and tolbutamide)].
Topics: Animals; Arteriosclerosis; Chickens; Cholesterol, Dietary; Disease Models, Animal; Eggs; Glyburide; | 1975 |
Effects of drugs on ventricular fibrillation and ischaemic K+ loss in a model of ischaemia in perfused guinea-pig hearts in vitro.
Topics: 4-Aminopyridine; Animals; Anti-Arrhythmia Agents; Benzothiazoles; Calcium Channel Blockers; Disease | 1992 |
[The vasospasmolytic effects of nicorandil, cromakalim and pinacidil on 3,4-diaminopyridine-induced phasic contractions in canine coronary arteries as an experimental vasospasm model].
Topics: 4-Aminopyridine; Amifampridine; Animals; Benzopyrans; Coronary Vasospasm; Cromakalim; Disease Models | 1992 |
[Glibornuride, a new high-effective antidiabetic agent. Pharmacological and biochemical comparative studies in various animal species and animal experimental models].
Topics: Administration, Oral; Animals; Blood Glucose; Camphanes; Chemical Phenomena; Chemistry; Cholesterol; | 1972 |