glyburide has been researched along with Cystic Fibrosis of Pancreas in 22 studies
Glyburide: An antidiabetic sulfonylurea derivative with actions like those of chlorpropamide
glyburide : An N-sulfonylurea that is acetohexamide in which the acetyl group is replaced by a 2-(5-chloro-2-methoxybenzamido)ethyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In our pursuit to identify potent modulators of Cl(-) secretion that may be useful to overcome the Cl(-) secretory defect in cystic fibrosis (CF), we have identified chlorzoxazone [5-chloro-2(3H)-benzoxazolone], a clinically used centrally acting muscle relaxant, as a stimulator of Cl(-) secretion in several epithelial cell types, including T84, Calu-3, and human bronchial epithelium." | 3.70 | Stimulation of Cl(-) secretion by chlorzoxazone. ( Bridges, RJ; Devor, DC; Gerlach, AC; Gondor, M; Pilewski, JM; Singh, AK, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.55) | 18.7374 |
| 1990's | 5 (22.73) | 18.2507 |
| 2000's | 13 (59.09) | 29.6817 |
| 2010's | 3 (13.64) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sheppard, DN | 1 |
| Welsh, MJ | 1 |
| Chung, WJ | 1 |
| Goeckeler-Fried, JL | 1 |
| Havasi, V | 1 |
| Chiang, A | 1 |
| Rowe, SM | 1 |
| Plyler, ZE | 1 |
| Hong, JS | 1 |
| Mazur, M | 1 |
| Piazza, GA | 1 |
| Keeton, AB | 1 |
| White, EL | 1 |
| Rasmussen, L | 1 |
| Weissman, AM | 1 |
| Denny, RA | 1 |
| Brodsky, JL | 1 |
| Sorscher, EJ | 2 |
| Buchanan, PJ | 1 |
| McNally, P | 1 |
| Harvey, BJ | 2 |
| Urbach, V | 2 |
| Michoud, MC | 1 |
| Robert, R | 1 |
| Hassan, M | 1 |
| Moynihan, B | 1 |
| Haston, C | 1 |
| Govindaraju, V | 1 |
| Ferraro, P | 1 |
| Hanrahan, JW | 1 |
| Martin, JG | 1 |
| Valdivieso, ÁG | 2 |
| Marín, MC | 1 |
| Clauzure, M | 1 |
| Santa-Coloma, TA | 2 |
| Cobb, BR | 1 |
| Fan, L | 1 |
| Kovacs, TE | 1 |
| Clancy, JP | 1 |
| Spirlì, C | 1 |
| Fiorotto, R | 1 |
| Song, L | 1 |
| Santos-Sacchi, J | 1 |
| Okolicsanyi, L | 1 |
| Masier, S | 1 |
| Rocchi, L | 1 |
| Vairetti, MP | 1 |
| De Bernard, M | 1 |
| Melero, S | 1 |
| Pozzan, T | 1 |
| Strazzabosco, M | 1 |
| Marcucci, F | 1 |
| Taminelli, G | 1 |
| Guerrico, AG | 1 |
| Alvarez, S | 1 |
| Teiber, ML | 1 |
| Dankert, MA | 1 |
| Klinghammer, A | 1 |
| Frey, G | 1 |
| Valverde, MA | 1 |
| O'Brien, JA | 1 |
| Sepúlveda, FV | 1 |
| Ratcliff, R | 1 |
| Evans, MJ | 1 |
| Colledge, WH | 1 |
| Tominaga, M | 1 |
| Horie, M | 1 |
| Okada, Y | 1 |
| Hongre, AS | 1 |
| Baró, I | 1 |
| Berthon, B | 1 |
| Escande, D | 1 |
| Mailleau, C | 1 |
| Capeau, J | 1 |
| Brahimi-Horn, MC | 1 |
| Singh, AK | 1 |
| Devor, DC | 1 |
| Gerlach, AC | 1 |
| Gondor, M | 1 |
| Pilewski, JM | 1 |
| Bridges, RJ | 1 |
| Mickle, JE | 1 |
| Milewski, MI | 1 |
| Macek, M | 1 |
| Cutting, GR | 1 |
| Gabriel, SE | 1 |
| Makhlina, M | 1 |
| Martsen, E | 1 |
| Thomas, EJ | 1 |
| Lethem, MI | 1 |
| Boucher, RC | 1 |
| Walsh, DE | 1 |
| Gao, L | 1 |
| Broughman, JR | 1 |
| Iwamoto, T | 1 |
| Tomich, JM | 1 |
| Venglarik, CJ | 1 |
| Forman, HJ | 1 |
| Fischer, H | 1 |
| Fukuda, N | 1 |
| Barbry, P | 1 |
| Illek, B | 1 |
| Sartori, C | 1 |
| Matthay, MA | 1 |
| Rosenecker, J | 1 |
| Eichler, I | 1 |
| Bärmeier, H | 1 |
| von der Hardt, H | 1 |
| Kibble, J | 1 |
| Neal, A | 1 |
| White, S | 1 |
| Green, R | 1 |
| Evans, S | 1 |
| Taylor, C | 1 |
| Gupta, J | 1 |
| Linsdell, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Comparative, Multicenter and Randomized Study Evaluating the Safety and Efficacy of RESPIMER® Netiflow® Versus Saline Solutions During Nasal Irrigation Following Bilateral Ethmoidectomy in the Treatment of Nasal Polyposis.[NCT02559284] | 189 participants (Actual) | Interventional | 2015-04-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
22 other studies available for glyburide and Cystic Fibrosis of Pancreas
| Article | Year |
|---|---|
Effect of ATP-sensitive K+ channel regulators on cystic fibrosis transmembrane conductance regulator chloride currents.
Topics: Adenosine Triphosphate; Animals; Cells, Cultured; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transm | 1992 |
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regu | 2016 |
Lipoxin A₄-mediated KATP potassium channel activation results in cystic fibrosis airway epithelial repair.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cell Line, Transformed; Cell Proliferation; Cystic Fibrosis | 2013 |
Role of the cystic fibrosis transmembrane conductance channel in human airway smooth muscle.
Topics: Asthma; Bronchi; Calcium; Calcium Channel Blockers; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosi | 2009 |
Measurement of cystic fibrosis transmembrane conductance regulator activity using fluorescence spectrophotometry.
Topics: Cells, Cultured; Chloride Channels; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regul | 2011 |
Adenosine receptors and phosphodiesterase inhibitors stimulate Cl- secretion in Calu-3 cells.
Topics: Adenosine Deaminase; Anions; Cell Line; Chlorine; Cilostazol; Colforsin; Cyclic AMP; Cystic Fibrosis | 2003 |
Glibenclamide stimulates fluid secretion in rodent cholangiocytes through a cystic fibrosis transmembrane conductance regulator-independent mechanism.
Topics: Animals; ATP-Binding Cassette Transporters; Bile Ducts; Body Fluids; Calcium; Cell Line; Cystic Fibr | 2005 |
The expression of the mitochondrial gene MT-ND4 is downregulated in cystic fibrosis.
Topics: Base Sequence; Benzoates; Cell Line; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regu | 2007 |
[Diabetes mellitus in mucoviscidosis in childhood].
Topics: Adolescent; Cystic Fibrosis; Female; Glyburide; Humans | 1983 |
Inactivation of the murine cftr gene abolishes cAMP-mediated but not Ca(2+)-mediated secretagogue-induced volume decrease in small-intestinal crypts.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Calcium; Carbachol; Chloride Channels; Cy | 1993 |
Additional similarity of cardiac cAMP-activated Cl- channels to CFTR Cl- channels.
Topics: Animals; Blotting, Northern; Chloride Channels; Colforsin; Cyclic AMP; Cystic Fibrosis; Glyburide; G | 1994 |
Effects of sulphonylureas on cAMP-stimulated Cl- transport via the cystic fibrosis gene product in human epithelial cells.
Topics: Adenosine Triphosphate; Blood Proteins; Cell Line; Chloride Channels; Colforsin; Cyclic AMP; Cystic | 1994 |
Interrelationship between the Na+/glucose cotransporter and CFTR in Caco-2 cells: relevance to cystic fibrosis.
Topics: Biological Transport; Caco-2 Cells; Calcium Channel Blockers; Cell Differentiation; Chlorides; Colfo | 1998 |
Stimulation of Cl(-) secretion by chlorzoxazone.
Topics: Amiloride; Anions; Bronchi; Bumetanide; Cell Membrane; Cells, Cultured; Charybdotoxin; Chlorine; Chl | 2000 |
Effects of cystic fibrosis and congenital bilateral absence of the vas deferens-associated mutations on cystic fibrosis transmembrane conductance regulator-mediated regulation of separate channels.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Amino Acid Substitution; Binding Sites; Cell Line; | 2000 |
Permeabilization via the P2X7 purinoreceptor reveals the presence of a Ca2+-activated Cl- conductance in the apical membrane of murine tracheal epithelial cells.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Bromine; Calcium; Calcium Channel Blocker | 2000 |
CFTR regulation of intracellular calcium in normal and cystic fibrosis human airway epithelia.
Topics: Adenosine Triphosphate; Calcium; Cell Line; Cells, Cultured; Colforsin; Cystic Fibrosis; Cystic Fibr | 2000 |
Synthetic chloride channel restores glutathione secretion in cystic fibrosis airway epithelia.
Topics: Cell Line, Transformed; Chloride Channels; Chlorzoxazone; Cystic Fibrosis; Drug Synergism; Electric | 2001 |
Partial restoration of defective chloride conductance in DeltaF508 CF mice by trimethylamine oxide.
Topics: Animals; Apigenin; Chloride Channels; Colforsin; Cystic Fibrosis; Cystic Fibrosis Transmembrane Cond | 2001 |
Diabetes mellitus and cystic fibrosis: comparison of clinical parameters in patients treated with insulin versus oral glucose-lowering agents.
Topics: Child; Child, Preschool; Cystic Fibrosis; Diabetes Complications; Diabetes Mellitus; Female; Glyburi | 2001 |
Renal effects of glibenclamide in cystic fibrosis mice.
Topics: Animals; Cystic Fibrosis; Diuretics; Glyburide; Kidney; Mice; Potassium; Reference Values | 2001 |
Point mutations in the pore region directly or indirectly affect glibenclamide block of the CFTR chloride channel.
Topics: Animals; Cell Line; Chlorides; Cricetinae; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductanc | 2002 |