glyburide has been researched along with Cerebral Infarction in 8 studies
Glyburide: An antidiabetic sulfonylurea derivative with actions like those of chlorpropamide
glyburide : An N-sulfonylurea that is acetohexamide in which the acetyl group is replaced by a 2-(5-chloro-2-methoxybenzamido)ethyl group.
Cerebral Infarction: The formation of an area of NECROSIS in the CEREBRUM caused by an insufficiency of arterial or venous blood flow. Infarcts of the cerebrum are generally classified by hemisphere (i.e., left vs. right), lobe (e.g., frontal lobe infarction), arterial distribution (e.g., INFARCTION, ANTERIOR CEREBRAL ARTERY), and etiology (e.g., embolic infarction).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Preclinical models of stroke have shown that intravenous glyburide reduces brain swelling and improves survival." | 9.22 | Safety and efficacy of intravenous glyburide on brain swelling after large hemispheric infarction (GAMES-RP): a randomised, double-blind, placebo-controlled phase 2 trial. ( Beslow, LA; Del Zoppo, GJ; Elm, JJ; Hinson, H; Jacobson, S; Kimberly, WT; Molyneaux, BJ; Ostwaldt, AC; Sheth, KN; Simard, JM; Sze, GK, 2016) |
| "Preclinical models of stroke have shown that intravenous glyburide reduces brain swelling and improves survival." | 5.22 | Safety and efficacy of intravenous glyburide on brain swelling after large hemispheric infarction (GAMES-RP): a randomised, double-blind, placebo-controlled phase 2 trial. ( Beslow, LA; Del Zoppo, GJ; Elm, JJ; Hinson, H; Jacobson, S; Kimberly, WT; Molyneaux, BJ; Ostwaldt, AC; Sheth, KN; Simard, JM; Sze, GK, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Vorasayan, P | 1 |
| Bevers, MB | 1 |
| Beslow, LA | 2 |
| Sze, G | 1 |
| Molyneaux, BJ | 2 |
| Hinson, HE | 1 |
| Simard, JM | 4 |
| von Kummer, R | 1 |
| Sheth, KN | 3 |
| Kimberly, WT | 3 |
| Jacobson, SM | 1 |
| MacAllister, TW | 1 |
| Geliebter, DM | 1 |
| King, ZA | 1 |
| Elm, JJ | 1 |
| Hinson, H | 1 |
| Sze, GK | 1 |
| Ostwaldt, AC | 1 |
| Del Zoppo, GJ | 1 |
| Jacobson, S | 1 |
| Yurovsky, V | 1 |
| Tsymbalyuk, N | 1 |
| Melnichenko, L | 1 |
| Ivanova, S | 1 |
| Gerzanich, V | 1 |
| Zhou, Y | 1 |
| Fathali, N | 1 |
| Lekic, T | 1 |
| Tang, J | 1 |
| Zhang, JH | 1 |
| Holstein, A | 1 |
| Lankes, HG | 1 |
| Egberts, EH | 1 |
| Golanov, EV | 1 |
| Christensen, JD | 1 |
| Reis, DJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized, Multi-Center, Prospective, Double Blind, Phase II Trial of RP- 1127 (Glyburide for Injection) in Patients With a Severe Anterior Circulation Ischemic Stroke Who Are Likely to Develop Malignant Edema[NCT01794182] | Phase 2 | 86 participants (Actual) | Interventional | 2013-06-13 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for glyburide and Cerebral Infarction
| Article | Year |
|---|---|
Found in translation: The rationale behind the early development of glibenclamide in large hemispheric infarction.
Topics: Animals; Brain Edema; Cerebral Infarction; Disease Models, Animal; Glyburide; Humans | 2020 |
Profile of intravenous glyburide for the prevention of cerebral edema following large hemispheric infarction: evidence to date.
Topics: Administration, Intravenous; Animals; Aquaporin 4; Brain; Brain Edema; Cerebral Infarction; Evidence | 2018 |
2 trials available for glyburide and Cerebral Infarction
| Article | Year |
|---|---|
Intravenous Glibenclamide Reduces Lesional Water Uptake in Large Hemispheric Infarction.
Topics: Administration, Intravenous; Aged; Cerebral Infarction; Female; Glyburide; Humans; Male; Middle Aged | 2019 |
Safety and efficacy of intravenous glyburide on brain swelling after large hemispheric infarction (GAMES-RP): a randomised, double-blind, placebo-controlled phase 2 trial.
Topics: Administration, Intravenous; Aged; Brain Edema; Cerebral Infarction; Double-Blind Method; Female; Gl | 2016 |
4 other studies available for glyburide and Cerebral Infarction
| Article | Year |
|---|---|
Protective effect of delayed treatment with low-dose glibenclamide in three models of ischemic stroke.
Topics: Animals; ATP-Binding Cassette Transporters; Brain; Brain Ischemia; Cerebral Infarction; Data Interpr | 2009 |
Glibenclamide improves neurological function in neonatal hypoxia-ischemia in rats.
Topics: Animals; Animals, Newborn; ATP-Binding Cassette Transporters; Behavior, Animal; Blood Glucose; Brain | 2009 |
[Diagnostic pitfalls in sulfonylurea-induced neuroglycopenic syndrome with hemiparesis, dysphasia and somnolence].
Topics: Aged; Aged, 80 and over; Aphasia; Cerebral Infarction; Consciousness Disorders; Diabetes Mellitus, T | 1998 |
Role of potassium channels in the central neurogenic neuroprotection elicited by cerebellar stimulation in rat.
Topics: Adenosine Triphosphate; Animals; Cerebellar Nuclei; Cerebral Infarction; Cerebral Ventricles; Electr | 1999 |