glyburide has been researched along with Cerebral Hemorrhage in 12 studies
Glyburide: An antidiabetic sulfonylurea derivative with actions like those of chlorpropamide
glyburide : An N-sulfonylurea that is acetohexamide in which the acetyl group is replaced by a 2-(5-chloro-2-methoxybenzamido)ethyl group.
Cerebral Hemorrhage: Bleeding into one or both CEREBRAL HEMISPHERES including the BASAL GANGLIA and the CEREBRAL CORTEX. It is often associated with HYPERTENSION and CRANIOCEREBRAL TRAUMA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Intravenous glyburide has demonstrated safety when used for attenuation of cerebral edema, although safety data are lacking for enteral glyburide when used for this indication." | 8.02 | Risk Factors for Hypoglycemia with the Use of Enteral Glyburide in Neurocritical Care Patients. ( Armahizer, MJ; Howard, AK; Kalasapudi, L; Morris, NA; Sansur, C; Seung, H, 2021) |
| "Intravenous glyburide has demonstrated safety when used for attenuation of cerebral edema, although safety data are lacking for enteral glyburide when used for this indication." | 4.02 | Risk Factors for Hypoglycemia with the Use of Enteral Glyburide in Neurocritical Care Patients. ( Armahizer, MJ; Howard, AK; Kalasapudi, L; Morris, NA; Sansur, C; Seung, H, 2021) |
| "Brain edema was quantified using the wet-dry method 3 days after injury." | 1.51 | Glibenclamide ameliorates the disrupted blood-brain barrier in experimental intracerebral hemorrhage by inhibiting the activation of NLRP3 inflammasome. ( He, Z; Shen, G; Su, Z; Xu, F; Yuan, L, 2019) |
| "Brain edema following intracerebral hemorrhage (ICH) causes severe secondary brain injury, and no efficient pharmacological preventions are available." | 1.46 | Role of Glibenclamide in Brain Injury After Intracerebral Hemorrhage. ( Chen, Q; Chen, Z; Feng, H; Jiang, B; Li, L; Tang, J; Tao, Y; Yang, L; Zhang, B; Zhang, JH; Zhu, G, 2017) |
| "To create HT model, right middle cerebral artery occlusion (MCAO) was conducted with intraluminal thread technique; 30 min after MCAO, 50 microL arterial blood was injected into the caudate nucleus where the infarction occurred." | 1.35 | Brain damage related to hemorrhagic transformation following cerebral ischemia and the role of K ATP channels. ( Li, LT; Yang, Y; Yin, J; Zhang, XJ, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (16.67) | 29.6817 |
| 2010's | 5 (41.67) | 24.3611 |
| 2020's | 5 (41.67) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, Y | 1 |
| Chen, S | 1 |
| Chang, J | 1 |
| Wei, J | 1 |
| Feng, M | 1 |
| Wang, R | 1 |
| Shiokawa, R | 1 |
| Otani, N | 1 |
| Kajimoto, R | 1 |
| Igarashi, T | 1 |
| Moro, N | 1 |
| Suma, T | 1 |
| Oshima, H | 1 |
| Yoshino, A | 1 |
| Armahizer, MJ | 1 |
| Howard, AK | 1 |
| Seung, H | 1 |
| Kalasapudi, L | 1 |
| Sansur, C | 1 |
| Morris, NA | 1 |
| Kung, TFC | 1 |
| Wilkinson, CM | 2 |
| Dirks, CA | 1 |
| Jickling, GC | 1 |
| Colbourne, F | 2 |
| Zhou, F | 1 |
| Liu, Y | 1 |
| Yang, B | 1 |
| Hu, Z | 1 |
| Xu, F | 1 |
| Shen, G | 1 |
| Su, Z | 1 |
| He, Z | 1 |
| Yuan, L | 1 |
| Brar, PS | 1 |
| Balay, CJ | 1 |
| Eisenberg, HM | 1 |
| Shenton, ME | 1 |
| Pasternak, O | 1 |
| Simard, JM | 2 |
| Okonkwo, DO | 1 |
| Aldrich, C | 1 |
| He, F | 1 |
| Jain, S | 1 |
| Hayman, EG | 1 |
| Jiang, B | 1 |
| Li, L | 1 |
| Chen, Q | 1 |
| Tao, Y | 1 |
| Yang, L | 1 |
| Zhang, B | 1 |
| Zhang, JH | 1 |
| Feng, H | 1 |
| Chen, Z | 1 |
| Tang, J | 1 |
| Zhu, G | 1 |
| Hallevi, H | 1 |
| Aronowski, J | 1 |
| Yang, Y | 1 |
| Zhang, XJ | 1 |
| Yin, J | 1 |
| Li, LT | 1 |
| Geng, Z | 1 |
| Silver, FL | 1 |
| Sheth, KN | 1 |
| Kimberly, WT | 1 |
| Stern, BJ | 1 |
| Colucci, M | 1 |
| Gerzanich, V | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Glibenclamide Advantage in Treating Edema After Intracerebral Hemorrhage (GATE-ICH): a Multi-center Randomized, Controlled, Assessor-blinded Trial[NCT03741530] | 220 participants (Actual) | Interventional | 2018-12-15 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for glyburide and Cerebral Hemorrhage
| Article | Year |
|---|---|
Perihematomal Edema After Intracerebral Hemorrhage: An Update on Pathogenesis, Risk Factors, and Therapeutic Advances.
Topics: Brain; Brain Edema; Cerebral Hemorrhage; Glyburide; Hematoma; Humans; Hypoglycemic Agents; Magnetic | 2021 |
Does inhibiting Sur1 complement rt-PA in cerebral ischemia?
Topics: Animals; Antioxidants; Aspirin; ATP-Binding Cassette Transporters; Brain Ischemia; Cells, Cultured; | 2012 |
1 trial available for glyburide and Cerebral Hemorrhage
| Article | Year |
|---|---|
Magnetic Resonance Imaging Pilot Study of Intravenous Glyburide in Traumatic Brain Injury.
Topics: Adult; Brain Edema; Brain Injuries, Traumatic; Cerebral Hemorrhage; Double-Blind Method; Female; Gly | 2020 |
9 other studies available for glyburide and Cerebral Hemorrhage
| Article | Year |
|---|---|
Glibenclamide attenuates brain edema associated with microglia activation after intracerebral hemorrhage.
Topics: Animals; Brain Edema; Cerebral Hemorrhage; Galectin 3; Glyburide; Hematoma; Microglia; Rats | 2022 |
Risk Factors for Hypoglycemia with the Use of Enteral Glyburide in Neurocritical Care Patients.
Topics: Administration, Oral; Adult; Aged; Body Mass Index; Brain Edema; Central Nervous System Neoplasms; C | 2021 |
Glibenclamide does not improve outcome following severe collagenase-induced intracerebral hemorrhage in rats.
Topics: Animals; Behavior, Animal; Blood-Brain Barrier; Brain Edema; Cerebral Hemorrhage; Collagenases; Dise | 2021 |
Neuroprotective potential of glibenclamide is mediated by antioxidant and anti-apoptotic pathways in intracerebral hemorrhage.
Topics: Animals; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Brain; Caspase 3; Cerebral Hemorrhage; | 2018 |
Glibenclamide ameliorates the disrupted blood-brain barrier in experimental intracerebral hemorrhage by inhibiting the activation of NLRP3 inflammasome.
Topics: Animals; Apoptosis; Blood-Brain Barrier; Brain Edema; Cerebral Hemorrhage; Cytokines; Glyburide; Inf | 2019 |
Glibenclamide, a Sur1-Trpm4 antagonist, does not improve outcome after collagenase-induced intracerebral hemorrhage.
Topics: Animals; Behavior, Animal; Blood Glucose; Blood-Brain Barrier; Brain; Brain Edema; Cerebral Hemorrha | 2019 |
Role of Glibenclamide in Brain Injury After Intracerebral Hemorrhage.
Topics: Animals; Blood Glucose; Blood-Brain Barrier; Brain Edema; Cerebral Hemorrhage; Endothelium; Glyburid | 2017 |
Life after SAINT.
Topics: Albumins; Antioxidants; Benzenesulfonates; Caffeine; Cerebral Hemorrhage; Clinical Trials, Phase II | 2007 |
Brain damage related to hemorrhagic transformation following cerebral ischemia and the role of K ATP channels.
Topics: Adenosine Triphosphatases; Animals; Brain; Brain Edema; Brain Infarction; Brain Ischemia; Cerebral H | 2008 |