glyburide has been researched along with Cardiomegaly in 11 studies
Glyburide: An antidiabetic sulfonylurea derivative with actions like those of chlorpropamide
glyburide : An N-sulfonylurea that is acetohexamide in which the acetyl group is replaced by a 2-(5-chloro-2-methoxybenzamido)ethyl group.
Cardiomegaly: Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Liraglutide ameliorates cardiac hypertrophy and apoptosis, potentially via activating KATP channel-mediated signaling pathway." | 8.02 | Glucagon-Like Peptide-1 Analog Liraglutide Attenuates Pressure-Overload Induced Cardiac Hypertrophy and Apoptosis through Activating ATP Sensitive Potassium Channels. ( Bai, XJ; Hao, JT; Wang, J; Yan, CP; Yang, CH; Zhang, WF; Zhao, ZQ; Zheng, RH, 2021) |
| "Liraglutide ameliorates cardiac hypertrophy and apoptosis, potentially via activating KATP channel-mediated signaling pathway." | 4.02 | Glucagon-Like Peptide-1 Analog Liraglutide Attenuates Pressure-Overload Induced Cardiac Hypertrophy and Apoptosis through Activating ATP Sensitive Potassium Channels. ( Bai, XJ; Hao, JT; Wang, J; Yan, CP; Yang, CH; Zhang, WF; Zhao, ZQ; Zheng, RH, 2021) |
| " Using combined transgenic and pharmacological approaches in a knockin mouse model of CS, we have shown that reversal of vascular and cardiac phenotypes can be achieved by genetic downregulation of KATP channel activity specifically in VSM, and by chronic administration of the clinically used KATP channel inhibitor, glibenclamide." | 1.56 | Glibenclamide reverses cardiovascular abnormalities of Cantu syndrome driven by KATP channel overactivity. ( Chalk, R; Halabi, CM; Harter, TM; Huang, Y; Kovacs, A; McClenaghan, C; Nichols, CG; Remedi, MS; van Haaften, G; Yan, Z, 2020) |
| "Cardiac hypertrophy has been demonstrated to decreases the ATP-sensitive potassium channels (K(ATP)), the major protective mechanism following the energy depletion, a common condition seen during the reperfusion after open heart surgery." | 1.32 | Ischemic preconditioning prevents reperfusion heart injury in cardiac hypertrophy by activation of mitochondrial KATP channels. ( Maeda, H; Rajesh, KG; Sasaguri, S; Suzuki, R; Xing, Y, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 4 (36.36) | 29.6817 |
| 2010's | 3 (27.27) | 24.3611 |
| 2020's | 3 (27.27) | 2.80 |
| Authors | Studies |
|---|---|
| McClenaghan, C | 3 |
| Huang, Y | 1 |
| Yan, Z | 1 |
| Harter, TM | 1 |
| Halabi, CM | 1 |
| Chalk, R | 1 |
| Kovacs, A | 1 |
| van Haaften, G | 2 |
| Remedi, MS | 1 |
| Nichols, CG | 3 |
| Zhao, G | 1 |
| Kaplan, A | 1 |
| Greiser, M | 1 |
| Lederer, WJ | 1 |
| Bai, XJ | 1 |
| Hao, JT | 1 |
| Zheng, RH | 1 |
| Yan, CP | 1 |
| Wang, J | 1 |
| Yang, CH | 1 |
| Zhang, WF | 1 |
| Zhao, ZQ | 1 |
| Cooper, PE | 1 |
| Chen, X | 2 |
| Stary-Weinzinger, A | 2 |
| Houtman, MJC | 1 |
| Qile, M | 1 |
| Duran, K | 1 |
| van der Heyden, MAG | 1 |
| Ma, A | 1 |
| Gurnasinghani, S | 1 |
| Kirk, EP | 1 |
| Singh, GK | 1 |
| Grange, DK | 1 |
| Pandit, C | 1 |
| Zhu, Y | 1 |
| Roscioli, T | 1 |
| Elakis, G | 1 |
| Buckley, M | 1 |
| Mehta, B | 1 |
| Roberts, P | 1 |
| Mervis, J | 1 |
| Biggin, A | 1 |
| Sanada, S | 1 |
| Node, K | 1 |
| Asanuma, H | 1 |
| Ogita, H | 1 |
| Takashima, S | 1 |
| Minamino, T | 1 |
| Asakura, M | 1 |
| Liao, Y | 1 |
| Ogai, A | 1 |
| Kim, J | 1 |
| Hori, M | 1 |
| Kitakaze, M | 1 |
| Rajesh, KG | 1 |
| Sasaguri, S | 1 |
| Suzuki, R | 1 |
| Xing, Y | 1 |
| Maeda, H | 1 |
| Xia, Y | 1 |
| Rajapurohitam, V | 1 |
| Cook, MA | 1 |
| Karmazyn, M | 1 |
| Shi, YX | 1 |
| Chen, Y | 1 |
| Zhu, YZ | 1 |
| Huang, GY | 1 |
| Moore, PK | 1 |
| Huang, SH | 1 |
| Yao, T | 1 |
| Zhu, YC | 1 |
| Ciampolillo, F | 1 |
| Tung, DE | 1 |
| Cameron, JS | 1 |
11 other studies available for glyburide and Cardiomegaly
| Article | Year |
|---|---|
Glibenclamide reverses cardiovascular abnormalities of Cantu syndrome driven by KATP channel overactivity.
Topics: Animals; Cardiomegaly; Disease Models, Animal; Gene Knock-In Techniques; Glyburide; Humans; Hypertri | 2020 |
The surprising complexity of KATP channel biology and of genetic diseases.
Topics: Animals; Cardiomegaly; Cardiovascular Abnormalities; Glyburide; Hypertrichosis; Mice; Osteochondrody | 2020 |
Glucagon-Like Peptide-1 Analog Liraglutide Attenuates Pressure-Overload Induced Cardiac Hypertrophy and Apoptosis through Activating ATP Sensitive Potassium Channels.
Topics: Animals; Apoptosis; Cardiomegaly; Drug Therapy, Combination; Glucagon-Like Peptide 1; Glyburide; KAT | 2021 |
Conserved functional consequences of disease-associated mutations in the slide helix of Kir6.1 and Kir6.2 subunits of the ATP-sensitive potassium channel.
Topics: Amino Acid Substitution; Animals; Cardiomegaly; Chlorocebus aethiops; COS Cells; Glyburide; Humans; | 2017 |
Glibenclamide and HMR1098 normalize Cantú syndrome-associated gain-of-function currents.
Topics: Adenosine Triphosphate; Cardiomegaly; Cryoelectron Microscopy; Gain of Function Mutation; Gene Expre | 2019 |
Glibenclamide treatment in a Cantú syndrome patient with a pathogenic ABCC9 gain-of-function variant: Initial experience.
Topics: Alleles; Cardiomegaly; Echocardiography; Female; Gain of Function Mutation; Genetic Association Stud | 2019 |
Opening of the adenosine triphosphate-sensitive potassium channel attenuates cardiac remodeling induced by long-term inhibition of nitric oxide synthesis: role of 70-kDa S6 kinase and extracellular signal-regulated kinase.
Topics: Adenosine Triphosphate; Animals; Blood Pressure; Body Weight; Cardiomegaly; Glyburide; Hydralazine; | 2002 |
Ischemic preconditioning prevents reperfusion heart injury in cardiac hypertrophy by activation of mitochondrial KATP channels.
Topics: Adenosine Triphosphate; Animals; Cardiomegaly; Decanoic Acids; Disease Models, Animal; Glyburide; He | 2004 |
Inhibition of phenylephrine induced hypertrophy in rat neonatal cardiomyocytes by the mitochondrial KATP channel opener diazoxide.
Topics: Adrenergic alpha-1 Receptor Agonists; Animals; Animals, Newborn; Anti-Arrhythmia Agents; Cardiomegal | 2004 |
Chronic sodium hydrosulfide treatment decreases medial thickening of intramyocardial coronary arterioles, interstitial fibrosis, and ROS production in spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Chemical Analysis; Blood Pressure; Cardiomegaly; Cardiotonic | 2007 |
Effects of diazoxide and glyburide on ATP-sensitive K+ channels from hypertrophied ventricular myocytes.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Cardiomegaly; Cells, Cultured; Diazoxide; Gl | 1992 |