glyburide has been researched along with Arrhythmias, Cardiac in 68 studies
Glyburide: An antidiabetic sulfonylurea derivative with actions like those of chlorpropamide
glyburide : An N-sulfonylurea that is acetohexamide in which the acetyl group is replaced by a 2-(5-chloro-2-methoxybenzamido)ethyl group.
Arrhythmias, Cardiac: Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effect of glibenclamide and glimepiride, two orally active antidiabetic sulphonylurea derivatives, was investigated on the development of reperfusion-induced arrhythmias and it was compared to their blood glucose lowering action." | 7.70 | Comparison of the efficacy of glibenclamide and glimepiride in reperfusion-induced arrhythmias in rats. ( Baczkó, I; Bozdogan, O; El-Reyani, NE; Leprán, I; Papp, JG, 1999) |
| "kg-1 iv 10 min before ischemia or ouabain infusion prevented ventricular fibrillation induced by ischemia in rat and arrhythmias induced by ouabain in guinea pig." | 7.68 | Effects of glibenclamide and tolbutamide on ischemia- and ouabain-induced arrhythmias and membrane potentials of ventricular myocardium from rat and guinea pig. ( Fu, SX; Li, YS; Yang, XP; Zhang, HL, 1991) |
| "53." | 5.34 | Hydrogen sulfide contributes to cardioprotection during ischemia-reperfusion injury by opening K ATP channels. ( Huang, H; Liu, P; Tang, C; Wang, J; Zhang, Z, 2007) |
| "The role of K(ATP) channels in the antiarrhythmic effect of Escherichia coli endotoxin-induced nitric oxide synthase (iNOS) was examined in an anesthetised rat model of myocardial ischemia and reperfusion arrhythmia by using glibenclamide (1 mg kg(-1)), nateglinide (10 mg kg(-1)) and repaglinide (0." | 3.74 | Glibenclamide attenuates the antiarrhythmic effect of endotoxin with a mechanism not involving K(ATP) channels. ( Erkent, U; Ertunc, M; Guc, MO; Ilhan, M; Iskit, AB; Onur, R, 2007) |
| "During aconitine-induced arrhythmias the antiarrhythmic effect of DALDA (Tyr-D-Arg-Phe-Lys-NH2) and nociceptin (orphanin FQ) administered intravenously depended on activation of nitric oxide synthase." | 3.72 | Possible mechanism underlying the antiarrhythmic effect of peptides nociceptin and DALDA on the heart. ( Krylatov, AV; Lishmanov, YB; Maslov, LN; Solenkova, NV; Stakheev, DL, 2003) |
| "Stimulation of cannabinoid receptors with endogenous cannabinoid anandamide and its enzyme-resistant analogue R-(+)-methanandamide improved cardiac resistance to arrhythmias induced by coronary occlusion and reperfusion." | 3.71 | Endogenous cannabinoids improve myocardial resistance to arrhythmogenic effects of coronary occlusion and reperfusion: a possible mechanism. ( Bernatskaya, NA; Krylatov, AV; Lishmanov, Y; Makriyannis, A; Maslov, LN; Mechoulam, R; Pertwee, RG; Sal'nikova, OM; Stefano, JB; Uzhachenko, RV, 2002) |
| "The effect of glibenclamide and glimepiride, two orally active antidiabetic sulphonylurea derivatives, was investigated on the development of reperfusion-induced arrhythmias and it was compared to their blood glucose lowering action." | 3.70 | Comparison of the efficacy of glibenclamide and glimepiride in reperfusion-induced arrhythmias in rats. ( Baczkó, I; Bozdogan, O; El-Reyani, NE; Leprán, I; Papp, JG, 1999) |
| " We have thus studied the effects of glibenclamide and cromakalim, KATP channel blocker and opener respectively, on membrane lipid injury and arrhythmias, in a model of ischemic-reperfused guinea-pig myocardium." | 3.70 | KATP channel modulators and myocardial damages induced by ischemia-reperfusion: membrane lipids injury and arrhythmias. ( Chesnay, F; Duval, D; Gérard, JL; Picard, S; Rouet, R, 1998) |
| " In order to investigate the role of KATP channel activation and repolarization dispersion on the 'border zone' arrhythmias induced by ischaemia-reperfusion, the effects of glibenclamide and bimakalim, agents modifying action potential (AP) duration, were studied in an in vitro model of myocardial 'border zone'." | 3.70 | KATP channels and 'border zone' arrhythmias: role of the repolarization dispersion between normal and ischaemic ventricular regions. ( Criniti, A; Ducouret, P; Flais, F; Gérard, JL; Monti, F; Picard, S; Puddu, PE; Rouet, R, 1999) |
| "We investigated the effect of ATP-sensitive K+ channel (KATP) openers (pinacidil and cromakalim), and a KATP blocker (glibenclamide) on reperfusion-induced arrhythmias in pentobarbitone-anaesthetized rats." | 3.69 | KATP channel modulators increase survival rate during coronary occlusion-reperfusion in anaesthetized rats. ( Baczkó, I; Leprán, I; Papp, JG, 1997) |
| "kg-1 iv 10 min before ischemia or ouabain infusion prevented ventricular fibrillation induced by ischemia in rat and arrhythmias induced by ouabain in guinea pig." | 3.68 | Effects of glibenclamide and tolbutamide on ischemia- and ouabain-induced arrhythmias and membrane potentials of ventricular myocardium from rat and guinea pig. ( Fu, SX; Li, YS; Yang, XP; Zhang, HL, 1991) |
| "Patients with type 2 diabetes are at increased susceptibility to a prolonged QT interval." | 2.79 | Lack of the QTc physiologic decrease during cardiac stress test in patients with type 2 diabetes treated with secretagogues. ( Amato, S; Baiocco, E; Curione, M; Di Bona, S; Gatti, A; Mandosi, E; Morano, S; Rossetti, M; Salvatore, S; Tarquini, G; Turinese, I; Varrenti, M, 2014) |
| "Glyburide was associated with a significant increase in QTc (433 +/- 24 to 467 +/- 24 ms, p <0." | 2.70 | Differential effect of glyburide (glibenclamide) and metformin on QT dispersion: a potential adenosine triphosphate sensitive K+ channel effect. ( Khan, IA; Molnar, J; Najeed, SA; Somberg, JC, 2002) |
| " The chronic use of mitochondrial K(ATP) channel agonists after infarction may attenuate the arrhythmogenic response to programmed electrical stimulation." | 1.35 | Effect of ATP-sensitive potassium channel agonists on sympathetic hyperinnervation in postinfarcted rat hearts. ( Chang, NC; Chen, CC; Kang, CS; Lee, TM; Lin, CC, 2009) |
| "There were fewer malignant arrhythmias with PerC during reperfusion (P = 0." | 1.34 | Intermittent peripheral tissue ischemia during coronary ischemia reduces myocardial infarction through a KATP-dependent mechanism: first demonstration of remote ischemic perconditioning. ( Cheung, M; Dzavik, V; Kharbanda, RK; Konstantinov, IE; Kristiansen, SB; Li, J; Redington, AN; Schmidt, MR; Shimizu, M; Smerup, M; Sorensen, K; White, PA, 2007) |
| "53." | 1.34 | Hydrogen sulfide contributes to cardioprotection during ischemia-reperfusion injury by opening K ATP channels. ( Huang, H; Liu, P; Tang, C; Wang, J; Zhang, Z, 2007) |
| "More importantly, the incidence of ventricular tachycardia in the STZ-GLIB group was significantly higher than that in the STZ-VEH group (93% vs 54%, P < 0." | 1.32 | Long-term treatment with glibenclamide increases susceptibility of streptozotocin-induced diabetic rat heart to reperfusion-induced ventricular tachycardia. ( Iwao, T; Ooie, T; Saikawa, T; Sakata, T; Takahashi, N; Yoshimatsu, H, 2003) |
| "However, for the safe treatment of arrhythmias nearly all presently known blockers lack sufficient selectivity, either within the target family or with respect to other ion channels modulating the cardiac action potential." | 1.32 | Blockers of the ATP-sensitive potassium channel SUR2A/Kir6.2: a new approach to prevent sudden cardiac death. ( Englert, HC; Gerlach, U; Heitsch, H; Knieps, S, 2003) |
| "The severity of arrhythmias (arrhythmia score, AS) was also markedly attenuated by both interventions (IPC: AS 1." | 1.31 | Preconditioning modulates susceptibility to ischemia-induced arrhythmias in the rat heart: the role of alpha-adrenergic stimulation and K(ATP) channels. ( Pancza, D; Ravingerová, T; Styk, J; Ziegelhoffer, A, 2002) |
| "Ventricular fibrillation was observed in 7/14 (control), 0/7 (glibenclamide), and 0/7 (HMR1883)." | 1.31 | Effects of the I(K.ATP) blockers glibenclamide and HMR1883 on cardiac electrophysiology during ischemia and reperfusion. ( Dhein, S; Krüsemann, K; Pejman, P, 2000) |
| "In untreated hearts, tachyarrhythmias occurred during the reperfusion, and less pronounced during the coronary occlusion itself." | 1.30 | Concerning the effect of the K+ channel blocking agent glibenclamide on ischaemic and reperfusion arrhythmias. ( Bernauer, W, 1997) |
| "Thirteen patients with type 2 diabetes, on combined insulin and glibenclamide treatment, were studied during hypoglycaemia, and eight of them participated in the euglycaemic experiment." | 1.30 | Increased QT dispersion during hypoglycaemia in patients with type 2 diabetes mellitus. ( Adamson, U; Englund, A; Landstedt-Hallin, L; Lins, PE, 1999) |
| "Glibenclamide increased the number of arrhythmias in the normoxic hearts from 1316+/-215 to 2091+/-187 (by 59%) and in the hypoxic group from 636+/-103 to 1777+/-186 (by 179%)." | 1.30 | Adaptation to high altitude hypoxia protects the rat heart against ischemia-induced arrhythmias. Involvement of mitochondrial K(ATP) channel. ( Asemu, G; Kolár, F; Ostádal, B; Papousek, F, 1999) |
| "Cromakalim is a member of the new antihypertensive drug family possessing an action that involves an increased K efflux in vascular and cardiac muscle." | 1.29 | Potassium channel openers and blockers: do they possess proarrhythmic or antiarrhythmic activity in ischemic and reperfused rat hearts? ( Das, DK; Engelman, RM; Szerdahelyi, P; Tosaki, A, 1993) |
| "Because of the occurrence of arrhythmias, cardiac function was not evaluated during reperfusion." | 1.28 | Effects of glibenclamide on ventricular arrhythmias and cardiac function in ischaemia and reperfusion in isolated rat heart. ( Bril, A; Gout, B; Laville, MP, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.47) | 18.7374 |
| 1990's | 36 (52.94) | 18.2507 |
| 2000's | 24 (35.29) | 29.6817 |
| 2010's | 6 (8.82) | 24.3611 |
| 2020's | 1 (1.47) | 2.80 |
| Authors | Studies |
|---|---|
| Englert, HC | 2 |
| Gerlach, U | 2 |
| Goegelein, H | 1 |
| Hartung, J | 1 |
| Heitsch, H | 2 |
| Mania, D | 1 |
| Scheidler, S | 1 |
| Coghlan, MJ | 1 |
| Carroll, WA | 1 |
| Gopalakrishnan, M | 1 |
| Cao, N | 1 |
| Wang, JJ | 1 |
| Wu, JM | 1 |
| Xu, WL | 1 |
| Wang, R | 1 |
| Chen, XD | 1 |
| Feng, YN | 1 |
| Cong, WW | 1 |
| Zhang, YY | 1 |
| Xiao, H | 1 |
| Dong, ED | 1 |
| Leonard, CE | 1 |
| Brensinger, CM | 1 |
| Aquilante, CL | 1 |
| Bilker, WB | 1 |
| Boudreau, DM | 1 |
| Deo, R | 1 |
| Flory, JH | 1 |
| Gagne, JJ | 1 |
| Mangaali, MJ | 1 |
| Hennessy, S | 1 |
| Kaya, ST | 1 |
| Bozdogan, O | 3 |
| Ozarslan, TO | 1 |
| Taskin, E | 1 |
| Eksioglu, D | 1 |
| Erim, F | 1 |
| Firat, T | 1 |
| Yasar, S | 1 |
| Reno, CM | 1 |
| Bayles, J | 1 |
| Skinner, A | 1 |
| Fisher, SJ | 1 |
| Dudek, M | 1 |
| Knutelska, J | 1 |
| Bednarski, M | 1 |
| Nowiński, L | 1 |
| Zygmunt, M | 1 |
| Bilska-Wilkosz, A | 1 |
| Iciek, M | 1 |
| Otto, M | 1 |
| Żytka, I | 1 |
| Sapa, J | 1 |
| Włodek, L | 1 |
| Filipek, B | 1 |
| Maslov, LN | 4 |
| Lishmanov, YB | 2 |
| Oeltgen, PR | 1 |
| Barzakh, EI | 1 |
| Krylatov, AV | 3 |
| Govindaswami, M | 1 |
| Brown, SA | 1 |
| Kang, CS | 1 |
| Chen, CC | 1 |
| Lin, CC | 1 |
| Chang, NC | 1 |
| Lee, TM | 1 |
| Lin, YK | 1 |
| Lai, MS | 1 |
| Chen, YC | 1 |
| Cheng, CC | 1 |
| Huang, JH | 1 |
| Chen, SA | 1 |
| Chen, YJ | 1 |
| Lin, CI | 1 |
| Curione, M | 1 |
| Di Bona, S | 1 |
| Amato, S | 1 |
| Turinese, I | 1 |
| Tarquini, G | 1 |
| Gatti, A | 1 |
| Mandosi, E | 1 |
| Rossetti, M | 1 |
| Varrenti, M | 1 |
| Salvatore, S | 1 |
| Baiocco, E | 1 |
| Morano, S | 1 |
| Ravingerová, T | 1 |
| Pancza, D | 1 |
| Ziegelhoffer, A | 1 |
| Styk, J | 1 |
| Najeed, SA | 1 |
| Khan, IA | 1 |
| Molnar, J | 1 |
| Somberg, JC | 1 |
| Uzhachenko, RV | 1 |
| Bernatskaya, NA | 1 |
| Makriyannis, A | 1 |
| Mechoulam, R | 1 |
| Pertwee, RG | 1 |
| Sal'nikova, OM | 1 |
| Stefano, JB | 1 |
| Lishmanov, Y | 1 |
| Solenkova, NV | 1 |
| Stakheev, DL | 1 |
| Riveline, JP | 1 |
| Danchin, N | 1 |
| Ledru, F | 1 |
| Varroud-Vial, M | 1 |
| Charpentier, G | 1 |
| Zhu, BM | 1 |
| Miyamoto, S | 1 |
| Nagasawa, Y | 1 |
| Wajima, T | 1 |
| Hashimoto, K | 1 |
| Takahashi, N | 1 |
| Ooie, T | 1 |
| Saikawa, T | 2 |
| Iwao, T | 1 |
| Yoshimatsu, H | 1 |
| Sakata, T | 2 |
| Knieps, S | 1 |
| Iskit, AB | 1 |
| Erkent, U | 1 |
| Ertunc, M | 1 |
| Guc, MO | 1 |
| Ilhan, M | 1 |
| Onur, R | 1 |
| Schmidt, MR | 1 |
| Smerup, M | 1 |
| Konstantinov, IE | 1 |
| Shimizu, M | 1 |
| Li, J | 1 |
| Cheung, M | 1 |
| White, PA | 1 |
| Kristiansen, SB | 1 |
| Sorensen, K | 1 |
| Dzavik, V | 1 |
| Redington, AN | 1 |
| Kharbanda, RK | 1 |
| Negroni, JA | 3 |
| Lascano, EC | 3 |
| del Valle, HF | 3 |
| Lishmanov, AY | 1 |
| Lasukova, TV | 1 |
| Crawford, D | 1 |
| Wong, TM | 1 |
| Zhang, Z | 1 |
| Huang, H | 1 |
| Liu, P | 1 |
| Tang, C | 1 |
| Wang, J | 1 |
| D'Alonzo, AJ | 4 |
| Sewter, JC | 3 |
| Darbenzio, RB | 4 |
| Hess, TA | 3 |
| Shigematsu, S | 1 |
| Sato, T | 1 |
| Abe, T | 1 |
| Arita, M | 1 |
| Moritani, K | 1 |
| Miyazaki, T | 1 |
| Miyoshi, S | 1 |
| Asanagi, M | 1 |
| Zhao, LS | 1 |
| Mitamura, H | 1 |
| Ogawa, S | 1 |
| Sleph, PG | 1 |
| Grover, GJ | 2 |
| Bellemin-Baurreau, J | 1 |
| Poizot, A | 1 |
| Hicks, PE | 1 |
| Rochette, L | 1 |
| Armstrong, JM | 1 |
| Tosaki, A | 2 |
| Szerdahelyi, P | 1 |
| Engelman, RM | 2 |
| Das, DK | 2 |
| Lu, H | 1 |
| Remeysen, P | 1 |
| De Clerck, F | 1 |
| Vegh, A | 1 |
| Papp, JG | 4 |
| Szekeres, L | 1 |
| Parratt, JR | 1 |
| Nakaya, H | 1 |
| Pogátsa, G | 2 |
| Engelman, DT | 1 |
| Kondo, T | 1 |
| Kubota, I | 1 |
| Tachibana, H | 1 |
| Yamaki, M | 1 |
| Tomoike, H | 1 |
| Baczkó, I | 2 |
| Leprán, I | 3 |
| Bernauer, W | 1 |
| Shivkumar, K | 1 |
| Deutsch, NA | 1 |
| Lamp, ST | 1 |
| Khuu, K | 1 |
| Goldhaber, JI | 1 |
| Weiss, JN | 1 |
| Matz, R | 1 |
| Zhu, JL | 1 |
| Dorso, CR | 1 |
| Barrett, TD | 1 |
| Walker, MJ | 1 |
| El-Reyani, NE | 1 |
| Picard, S | 2 |
| Rouet, R | 2 |
| Duval, D | 1 |
| Chesnay, F | 1 |
| Gérard, JL | 2 |
| Wolk, R | 1 |
| Cobbe, SM | 1 |
| Kane, KA | 1 |
| Hicks, MN | 1 |
| Du Toit, EF | 1 |
| Muller, CA | 1 |
| McCarthy, J | 1 |
| Opie, LH | 2 |
| Ducouret, P | 1 |
| Puddu, PE | 1 |
| Flais, F | 1 |
| Criniti, A | 1 |
| Monti, F | 1 |
| Tokuno, T | 1 |
| Muraki, K | 1 |
| Watanabe, M | 1 |
| Imaizumi, Y | 1 |
| Landstedt-Hallin, L | 1 |
| Englund, A | 1 |
| Adamson, U | 1 |
| Lins, PE | 1 |
| Asemu, G | 1 |
| Papousek, F | 1 |
| Ostádal, B | 1 |
| Kolár, F | 1 |
| Wirth, KJ | 1 |
| Klaus, E | 1 |
| Englert, HG | 1 |
| Schölkens, BA | 1 |
| Linz, W | 1 |
| Lee, YM | 1 |
| Peng, YY | 1 |
| Sheu, JR | 1 |
| Cheng, CY | 1 |
| Yen, MH | 1 |
| Light, PE | 1 |
| Cordeiro, JM | 1 |
| French, RJ | 1 |
| Dhein, S | 1 |
| Pejman, P | 1 |
| Krüsemann, K | 1 |
| Workman, AJ | 2 |
| MacKenzie, I | 2 |
| Northover, BJ | 2 |
| Crottogini, AJ | 2 |
| Remme, CA | 1 |
| Schumacher, CA | 1 |
| de Jong, JW | 1 |
| Fiolet, JW | 1 |
| de Groot, JR | 1 |
| Coronel, R | 1 |
| Wilde, AA | 1 |
| Yazar, A | 1 |
| Polat, G | 1 |
| Un, I | 1 |
| Levent, A | 1 |
| Kaygusuz, A | 1 |
| Büyükafşar, K | 1 |
| çamdeviren, H | 1 |
| Bril, A | 1 |
| Laville, MP | 1 |
| Gout, B | 1 |
| Zhang, HL | 1 |
| Li, YS | 1 |
| Fu, SX | 1 |
| Yang, XP | 1 |
| Kantor, PF | 1 |
| Coetzee, WA | 1 |
| Carmeliet, EE | 1 |
| Dennis, SC | 1 |
| Ballagi-Pordány, G | 1 |
| Köszeghy, A | 1 |
| Koltai, MZ | 1 |
| Aranyi, Z | 1 |
| Bekheit, SS | 1 |
| Restivo, M | 1 |
| Boutjdir, M | 1 |
| Henkin, R | 1 |
| Gooyandeh, K | 1 |
| Assadi, M | 1 |
| Khatib, S | 1 |
| Gough, WB | 1 |
| el-Sherif, N | 1 |
| Wolleben, CD | 1 |
| Sanguinetti, MC | 1 |
| Siegl, PK | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Remote Preconditioning in Primary Percutaneous Intervention of Acute ST Elevation Myocardial Infarction[NCT00435266] | Phase 2/Phase 3 | 250 participants (Anticipated) | Interventional | 2007-02-28 | Completed | ||
| Remote Ischemic Preconditioning in Head and Neck Cancer Reconstruction - A Randomized Controlled Trial[NCT02548377] | 60 participants (Actual) | Interventional | 2015-09-29 | Completed | |||
| Predicting Hypoglycaemia and Arrhythmias in the Vulnerable Patient With Diabetes and Chronic Kidney Disease - Validation Study[NCT02778269] | 7 participants (Actual) | Interventional | 2016-06-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for glyburide and Arrhythmias, Cardiac
| Article | Year |
|---|---|
Recent developments in the biology and medicinal chemistry of potassium channel modulators: update from a decade of progress.
Topics: Adenosine Triphosphate; Angina Pectoris; Arrhythmias, Cardiac; Asthma; Calcium; Ion Channel Gating; | 2001 |
Sulfonylureas and cardiovascular effects: from experimental data to clinical use. Available data in humans and clinical applications.
Topics: Animals; Arrhythmias, Cardiac; Cardiovascular Physiological Phenomena; Coronary Circulation; Glyburi | 2003 |
Glibenclamide action on myocardial function and arrhythmia incidence in the healthy and diabetic heart.
Topics: Animals; Arrhythmias, Cardiac; Calcium; Diabetes Complications; Glyburide; Heart; Humans; Hypoglycem | 2007 |
[Potential role of ATP-sensitive K+ channels in ischemia- and reperfusion-induced arrhythmias].
Topics: Action Potentials; Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Benzopyrans; Cromakalim; G | 1993 |
Potassium channels in the cardiovascular system.
Topics: Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Cardiovascular Physiological Phenomena; Cardi | 1995 |
2 trials available for glyburide and Arrhythmias, Cardiac
| Article | Year |
|---|---|
Lack of the QTc physiologic decrease during cardiac stress test in patients with type 2 diabetes treated with secretagogues.
Topics: Aged; Arrhythmias, Cardiac; Carbamates; Diabetes Mellitus, Type 2; Electrocardiography; Exercise Tes | 2014 |
Differential effect of glyburide (glibenclamide) and metformin on QT dispersion: a potential adenosine triphosphate sensitive K+ channel effect.
Topics: Administration, Oral; Adult; Aged; Arrhythmias, Cardiac; Diabetes Mellitus, Type 2; Electrocardiogra | 2002 |
61 other studies available for glyburide and Arrhythmias, Cardiac
| Article | Year |
|---|---|
Cardioselective K(ATP) channel blockers derived from a new series of m-anisamidoethylbenzenesulfonylthioureas.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; AT | 2001 |
Glibenclamide alleviates β adrenergic receptor activation-induced cardiac inflammation.
Topics: Animals; Arrhythmias, Cardiac; Glyburide; Inflammasomes; Inflammation; Isoproterenol; Male; Mice; Mi | 2022 |
Comparative Safety of Sulfonylureas and the Risk of Sudden Cardiac Arrest and Ventricular Arrhythmia.
Topics: Aged; Arrhythmias, Cardiac; Cause of Death; Death, Sudden, Cardiac; Diabetic Angiopathies; Female; G | 2018 |
The protection of resveratrol and its combination with glibenclamide, but not berberine on the diabetic hearts against reperfusion-induced arrhythmias: the role of myocardial K
Topics: Animals; Arrhythmias, Cardiac; Berberine; Diabetes Mellitus, Experimental; Dose-Response Relationshi | 2019 |
Glibenclamide Prevents Hypoglycemia-Induced Fatal Cardiac Arrhythmias in Rats.
Topics: Animals; Arrhythmias, Cardiac; Diazoxide; Glyburide; Heart Rate; Hypoglycemia; Insulin; Male; Random | 2018 |
Alpha lipoic acid protects the heart against myocardial post ischemia-reperfusion arrhythmias via KATP channel activation in isolated rat hearts.
Topics: Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Animals; Antioxidants; Arrhythmias, C | 2014 |
Activation of peripheral delta2 opioid receptors increases cardiac tolerance to ischemia/reperfusion injury Involvement of protein kinase C, NO-synthase, KATP channels and the autonomic nervous system.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Autonomic Nervous System; Benzophenanthridine | 2009 |
Effect of ATP-sensitive potassium channel agonists on sympathetic hyperinnervation in postinfarcted rat hearts.
Topics: Animals; Arrhythmias, Cardiac; Echocardiography; Endothelin-1; Glyburide; Heart; Hypoglycemic Agents | 2009 |
Hypoxia and reoxygenation modulate the arrhythmogenic activity of the pulmonary vein and atrium.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Atrial Fibrillation; Blotting, Western; Chloramphe | 2012 |
Preconditioning modulates susceptibility to ischemia-induced arrhythmias in the rat heart: the role of alpha-adrenergic stimulation and K(ATP) channels.
Topics: Adenosine Triphosphate; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Ant | 2002 |
Endogenous cannabinoids improve myocardial resistance to arrhythmogenic effects of coronary occlusion and reperfusion: a possible mechanism.
Topics: Animals; Anti-Arrhythmia Agents; Arachidonic Acids; Arrhythmias, Cardiac; Calcium Channel Blockers; | 2002 |
Possible mechanism underlying the antiarrhythmic effect of peptides nociceptin and DALDA on the heart.
Topics: Aconitine; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Electrocardiography; Glyburide; In | 2003 |
Effect of the sarcolemmal K(ATP) channel blocker HMR1098 on arrhythmias induced by programmed electrical stimulation in canine old myocardial infarction model: comparison with glibenclamide.
Topics: Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Benzamides; Disease Models, Animal; Dogs; Ele | 2003 |
Long-term treatment with glibenclamide increases susceptibility of streptozotocin-induced diabetic rat heart to reperfusion-induced ventricular tachycardia.
Topics: Animals; Arrhythmias, Cardiac; Blood Glucose; Blood Pressure; Body Weight; Creatine Kinase; Diabetes | 2003 |
Blockers of the ATP-sensitive potassium channel SUR2A/Kir6.2: a new approach to prevent sudden cardiac death.
Topics: Action Potentials; Adenosine Triphosphate; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; ATP-Binding | 2003 |
Glibenclamide attenuates the antiarrhythmic effect of endotoxin with a mechanism not involving K(ATP) channels.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Blood Pressure; Carbamates | 2007 |
Intermittent peripheral tissue ischemia during coronary ischemia reduces myocardial infarction through a KATP-dependent mechanism: first demonstration of remote ischemic perconditioning.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Body Temperature; Ele | 2007 |
Intermittent peripheral tissue ischemia during coronary ischemia reduces myocardial infarction through a KATP-dependent mechanism: first demonstration of remote ischemic perconditioning.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Body Temperature; Ele | 2007 |
Intermittent peripheral tissue ischemia during coronary ischemia reduces myocardial infarction through a KATP-dependent mechanism: first demonstration of remote ischemic perconditioning.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Body Temperature; Ele | 2007 |
Intermittent peripheral tissue ischemia during coronary ischemia reduces myocardial infarction through a KATP-dependent mechanism: first demonstration of remote ischemic perconditioning.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Body Temperature; Ele | 2007 |
Activation of kappa-opioid receptor as a method for prevention of ischemic and reperfusion arrhythmias: role of protein kinase C and K(ATP) channels.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Alkaloids; | 2007 |
Hydrogen sulfide contributes to cardioprotection during ischemia-reperfusion injury by opening K ATP channels.
Topics: Animals; Arrhythmias, Cardiac; Cardiotonic Agents; Cells, Cultured; Glyburide; Heart; Hydrogen Sulfi | 2007 |
Effects of cromakalim or glibenclamide on arrhythmias and dispersion of refractoriness in chronically infarcted in anesthetized dogs.
Topics: Adenosine Triphosphate; Anesthesia; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzopyra | 1995 |
Effects of intracoronary glyburide on cesium-induced arrhythmias in anesthetized dogs.
Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium; Cesium; Coronary Circula | 1994 |
Pharmacological evidence for the persistent activation of ATP-sensitive K+ channels in early phase of reperfusion and its protective role against myocardial stunning.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Benzopyrans; Cromakalim; G | 1995 |
Blockade of ATP-sensitive potassium channels by 5-hydroxydecanoate suppresses monophasic action potential shortening during regional myocardial ischemia.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bl | 1994 |
Effect of potassium on the action of the KATP modulators cromakalim, pinacidil, or glibenclamide on arrhythmias in isolated perfused rat heart subjected to regional ischaemia.
Topics: Animals; Arrhythmias, Cardiac; Benzopyrans; Cromakalim; Glyburide; Guanidines; Heart; Heart Rate; My | 1994 |
Effects of ATP-dependent K+ channel modulators on an ischemia-reperfusion rabbit isolated heart model with programmed electrical stimulation.
Topics: Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Benzopyrans; Blood Pressure; Coronary Circula | 1994 |
Potassium channel openers and blockers: do they possess proarrhythmic or antiarrhythmic activity in ischemic and reperfused rat hearts?
Topics: Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Arrhythmias, Cardiac; Benzopyrans; Cations | 1993 |
The protection by ischemic preconditioning against myocardial ischemia- and reperfusion-induced arrhythmias is not mediated by ATP-sensitive potassium channels in rats.
Topics: Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Glyburide; Hemodynamics; Male; Myocardial Isc | 1993 |
Are ATP sensitive potassium channels involved in the pronounced antiarrhythmic effects of preconditioning?
Topics: Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Dogs; Female; Glyburide; Male; Myocardial Isc | 1993 |
Diabetes and ATP-sensitive potassium channel openers and blockers in isolated ischemic/reperfused hearts.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzopyrans; Cations; | 1995 |
Glibenclamide attenuates peaked T wave in early phase of myocardial ischemia.
Topics: Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Dogs; Electrocardiography; Glyburide; Myocard | 1996 |
KATP channel modulators increase survival rate during coronary occlusion-reperfusion in anaesthetized rats.
Topics: Action Potentials; Adenosine Triphosphate; Analysis of Variance; Animals; Anti-Arrhythmia Agents; Ar | 1997 |
Concerning the effect of the K+ channel blocking agent glibenclamide on ischaemic and reperfusion arrhythmias.
Topics: Adenosine; Animals; Arrhythmias, Cardiac; Coronary Circulation; Drug Evaluation, Preclinical; Glybur | 1997 |
Effect of glimepiride and glibenclamide, inhibitors of ATP-dependent K(+)-channel, on ischaemia-reperfusion induced arrhythmias in rats.
Topics: Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Dose-Response Relationship, Drug; Glyburide; | 1996 |
Mechanism of hypoxic K loss in rabbit ventricle.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Biological Transport; Cromakalim; Glyburide; Heart | 1997 |
Sulfonylureas and ischemic heart disease.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Glyburide; Heart; Humans; Hypoglycemic Agents | 1998 |
Proarrhythmic effects of pinacidil are partially mediated through enhancement of catecholamine release in isolated perfused guinea-pig hearts.
Topics: Adenosine Triphosphate; Adrenergic Agonists; Adrenergic beta-Antagonists; Animals; Arrhythmias, Card | 1998 |
Glibenclamide does not prevent action potential shortening induced by ischemia in anesthetized rabbits but reduces ischemia-induced arrhythmias.
Topics: Action Potentials; Analysis of Variance; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bloo | 1998 |
Comparison of the efficacy of glibenclamide and glimepiride in reperfusion-induced arrhythmias in rats.
Topics: Anesthesia; Animals; Arrhythmias, Cardiac; Blood Glucose; Blood Pressure; Coronary Vessels; Glyburid | 1999 |
KATP channel modulators and myocardial damages induced by ischemia-reperfusion: membrane lipids injury and arrhythmias.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Cromakalim; Electrophysiology; Fatty Acids, Nonest | 1998 |
Relevance of inter- and intraventricular electrical dispersion to arrhythmogenesis in normal and ischaemic rabbit myocardium: a study with cromakalim, 5-hydroxydecanoate and glibenclamide.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Disease; Cromakal | 1999 |
Levosimendan: effects of a calcium sensitizer on function and arrhythmias and cyclic nucleotide levels during ischemia/reperfusion in the Langendorff-perfused guinea pig heart.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium Channel Agoni | 1999 |
KATP channels and 'border zone' arrhythmias: role of the repolarization dispersion between normal and ischaemic ventricular regions.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; ATP-Binding Cassette Transporters; Benzopyrans; Di | 1999 |
Effects of K+ channel modulators on the relationship between action potential duration and Ca2+ transients in single ventricular myocytes of the guinea pig.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium; Cromakalim; Glybu | 1999 |
Increased QT dispersion during hypoglycaemia in patients with type 2 diabetes mellitus.
Topics: Aged; Arrhythmias, Cardiac; Diabetes Mellitus, Type 2; Electrocardiography; Female; Glucose Clamp Te | 1999 |
Adaptation to high altitude hypoxia protects the rat heart against ischemia-induced arrhythmias. Involvement of mitochondrial K(ATP) channel.
Topics: Acclimatization; Altitude; Animals; Arrhythmias, Cardiac; Glyburide; Heart; Heart Rate; Heart Ventri | 1999 |
HMR 1883, a cardioselective K(ATP) channel blocker, inhibits ischaemia- and reperfusion-induced ventricular fibrillation in rats.
Topics: Adenosine Triphosphate; Administration, Oral; Animals; Arrhythmias, Cardiac; Arterial Occlusive Dise | 1999 |
The effects of a newly synthesized ATP-sensitive potassium channel opener, MJ-355, on blood pressure and myocardial ischemia-reperfusion injury in rats.
Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Arrhythmias, Cardiac; ATP-Bind | 1999 |
Identification and properties of ATP-sensitive potassium channels in myocytes from rabbit Purkinje fibres.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Cell Separation; Computer | 1999 |
Effects of the I(K.ATP) blockers glibenclamide and HMR1883 on cardiac electrophysiology during ischemia and reperfusion.
Topics: Animals; Arrhythmias, Cardiac; Electrocardiography; Electrophysiology; Glyburide; Heart; In Vitro Te | 2000 |
Do KATP channels open as a prominent and early feature during ischaemia in the Langendorff-perfused rat heart?
Topics: Action Potentials; Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Benzopyrans; Coronary Dise | 2000 |
A K(ATP) channel opener inhibited myocardial reperfusion action potential shortening and arrhythmias.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Antihypertensive Agents; Arrhythmias, Cardiac; B | 2001 |
Glibenclamide effects on reperfusion-induced malignant arrhythmias and left ventricular mechanical recovery from stunning in conscious sheep.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Glyburide; Hemodynamics; H | 2001 |
K(ATP) channel opening during ischemia: effects on myocardial noradrenaline release and ventricular arrhythmias.
Topics: Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Coronary Circulation; Cromakalim; Female; Gly | 2001 |
Effects of glibenclamide, metformin and insulin on the incidence and latency of death by oubain-induced arrhythmias in mice.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Glucose; Cardiotonic Agents; Female; Gl | 2002 |
ATP-sensitive potassium channels do not have a main role in mediating late preconditioning protection against arrhythmias and stunning in conscious sheep.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Co | 2002 |
Effects of glibenclamide on ventricular arrhythmias and cardiac function in ischaemia and reperfusion in isolated rat heart.
Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Coronary Circulation; Coronary Vessels; Glyburide; He | 1992 |
Effects of glibenclamide and tolbutamide on ischemia- and ouabain-induced arrhythmias and membrane potentials of ventricular myocardium from rat and guinea pig.
Topics: Animals; Arrhythmias, Cardiac; Dose-Response Relationship, Drug; Female; Glyburide; Guinea Pigs; Hyp | 1991 |
Reduction of ischemic K+ loss and arrhythmias in rat hearts. Effect of glibenclamide, a sulfonylurea.
Topics: Animals; Arrhythmias, Cardiac; Coronary Disease; Glyburide; Heart; Lactates; Lactic Acid; Male; Myoc | 1990 |
Divergent cardiac effects of the first and second generation hypoglycemic sulfonylurea compounds.
Topics: Animals; Arrhythmias, Cardiac; Blood Glucose; Carbutamide; Dose-Response Relationship, Drug; Electro | 1990 |
Effects of glyburide on ischemia-induced changes in extracellular potassium and local myocardial activation: a potential new approach to the management of ischemia-induced malignant ventricular arrhythmias.
Topics: Animals; Arrhythmias, Cardiac; Blood Glucose; Coronary Disease; Dogs; Electrocardiography; Glyburide | 1990 |
Influence of ATP-sensitive potassium channel modulators on ischemia-induced fibrillation in isolated rat hearts.
Topics: Adenosine Triphosphate; Animals; Antihypertensive Agents; Arrhythmias, Cardiac; Benzopyrans; Coronar | 1989 |