Compounds > glyburide
Page last updated: 2024-10-28

glyburide and Anoxemia

glyburide has been researched along with Anoxemia in 136 studies

Glyburide: An antidiabetic sulfonylurea derivative with actions like those of chlorpropamide
glyburide : An N-sulfonylurea that is acetohexamide in which the acetyl group is replaced by a 2-(5-chloro-2-methoxybenzamido)ethyl group.

Research Excerpts

ExcerptRelevanceReference
"In rat carotid artery, levcromakalim produced vasorelaxation mediated by adenosine triphosphate (ATP)-sensitive K(+) channels, whereas hypoxia induced it partly via these channels."7.72The role of K+ channels in vasorelaxation induced by hypoxia and the modulator effects of lidocaine in the rat carotid artery. ( Dojo, M; Hatano, Y; Iranami, H; Kimoto, Y; Kinoshita, H; Nakahata, K, 2003)
" The effects of NG-monomethyl-L-arginine, tetrodotoxin and glibenclamide on hypoxia-induced coronary artery relaxation, induced by bubbling Krebs solution with 95% N2 and 5% CO2 instead of 95% O2 and 5% CO2, were assessed by measuring the changes in isometric tension in isolated epicardial coronary artery rings of the rabbit."7.69Inhibition of hypoxia-induced relaxation of rabbit isolated coronary arteries by NG-monomethyl-L-arginine but not glibenclamide. ( Collins, P; Jiang, C, 1994)
" The effects of phentolamine (5-30 microM) and glibenclamide (10 microM) on action potential characteristics were examined in guinea-pig papillary muscle exposed to either hypoxia or levcromakalim (20 microM)."7.68Attenuation by phentolamine of hypoxia and levcromakalim-induced abbreviation of the cardiac action potential. ( Boachie-Anash, G; Henderson, CG; Kane, KA; Tweedie, D, 1993)
"kg-1 iv 10 min before ischemia or ouabain infusion prevented ventricular fibrillation induced by ischemia in rat and arrhythmias induced by ouabain in guinea pig."7.68Effects of glibenclamide and tolbutamide on ischemia- and ouabain-induced arrhythmias and membrane potentials of ventricular myocardium from rat and guinea pig. ( Fu, SX; Li, YS; Yang, XP; Zhang, HL, 1991)
"In LEVO-pretreated hypoxemia, CO was significantly higher compared to unpretreated hypoxemia."5.37The effects of levosimendan and glibenclamide on circulatory and metabolic variables in a canine model of acute hypoxia. ( Picker, O; Schober, P; Schwarte, LA; Schwartges, I; Thomas, K, 2011)
"Desflurane or propofol was applied 10 min before and during 10 min of hypoxia (95% nitrogen, 5% carbon dioxide)."5.35Effects of desflurane and propofol on electrophysiological parameters during and recovery after hypoxia in rat hippocampal slice CA1 pyramidal cells. ( Cottrell, JE; Kass, IS; Wang, J, 2009)
"Adenosine dilation was also blunted by glibenclamide, a KATP antagonist (9 +/- 2, 14 +/- 3, 21 +/- 4 vs."5.30Role of nitric oxide, cyclic nucleotides, and the activation of ATP-sensitive K+ channels in the contribution of adenosine to hypoxia-induced pial artery dilation. ( Armstead, WM, 1997)
" In arteries with endothelium and contracted with phenylephrine, hypoxia, evoked by exchanging 5% CO2 in air for CO2 in N2, caused a transient contraction followed by a sustained contraction."3.73Glibenclamide reveals role for endothelin in hypoxia-induced vasoconstriction in rat intrapulmonary arteries. ( Andersen, CU; Laursen, BE; López-Valverde, V; Mulvany, MJ; Simonsen, U, 2005)
"In rat carotid artery, levcromakalim produced vasorelaxation mediated by adenosine triphosphate (ATP)-sensitive K(+) channels, whereas hypoxia induced it partly via these channels."3.72The role of K+ channels in vasorelaxation induced by hypoxia and the modulator effects of lidocaine in the rat carotid artery. ( Dojo, M; Hatano, Y; Iranami, H; Kimoto, Y; Kinoshita, H; Nakahata, K, 2003)
"The K(ATP) channel activator, diazoxide (100 microM, n=6) or hypoxia (0% O2/5% CO2, n=6) significantly attenuated the HR response to 3 Hz SNS by -10+/-4% and -27+/-6% respectively; an effect that was reversed by the K(ATP) channel inhibitor, glibenclamide (30 microM)."3.70Activation of sulphonylurea-sensitive channels and the NO-cGMP pathway decreases the heart rate response to sympathetic nerve stimulation. ( Mohan, RM; Paterson, DJ, 2000)
"We investigated whether the adenosine triphosphate (ATP)-sensitive K+ (K(ATP)) channel activation by bimakalim, at concentrations devoid of both negative inotropic and action-potential duration (APD) shortening effects, might exhibit myocardial protection after hypoxia and reoxygenation in human atrial myocardium by using 112 preparations."3.70Protection of human myocardium in vitro by K(ATP) activation with low concentrations of bimakalim. ( Criniti, A; del Monte, F; Ducouret, P; Iwashiro, K; Monti, F; Papalia, U; Picard, S; Puddu, PE; Rouet, R; Ruvolo, G; Tonelli, E, 1999)
" In addition, cerebral arteriolar dilation to hypoxia and adenosine is maintained after ischemia despite the expected impairment in K(ATP) function."3.70Effects of ischemia on cerebral arteriolar dilation to arterial hypoxia in piglets. ( Bari, F; Busija, DW; Louis, TM, 1998)
" The present studies examined the role of adenosine triphosphate-sensitive potassium channels (KATP channels) in modulating the pressor and vasoconstrictor responses to phenylephrine (PE) in conscious instrumented rats 1) during acute hypoxia or 2) after chronic hypoxic exposure."3.69Glibenclamide does not reverse attenuated vasoreactivity to acute or chronic hypoxia. ( Balderrama, DS; Eichinger, MR; Herrera, GM; Resta, JM; Resta, TC; Richardson, LA; Walker, BR, 1995)
"We assessed the role of extracellular potassium ([K+]e) on the increase in cerebral blood flow (CBF) during hypoxia, and we tested whether it was affected by glibenclamide or ouabain."3.69Role of K+ in regulating hypoxic cerebral blood flow in the rat: effect of glibenclamide and ouabain. ( Paterson, DJ; Reid, JM, 1996)
"The effects of N omega-nitro-L-arginine methyl ester, an inhibitor of nitric oxide synthase; 6-anilino-5,8-quinolinedione (LY83583), an inhibitor of soluble guanylate cyclase; glybenclamide, a ATP-sensitive K+ channel blocking agent; and 5,7-dimethyl-2-ethyl-3-[[2'-(1H-tetrazol-5-yl)-[1,1']-biphenyl-4- yl]methyl]-3H-imidazo[4,5-b]pyridine (L158809), an angiotensin II type I receptor antagonist, on the response to ventilatory hypoxia were investigated in the isolated blood-perfused rat lung."3.69Influence of N omega-nitro-L-arginine methyl ester, LY83583, glybenclamide and L158809 on pulmonary circulation. ( Cheng, DY; Feng, CJ; Kadowitz, PJ; Kaye, AD; Nossaman, BD, 1994)
" The decrease of coronary perfusion pressure induced by hypoxia and by various concentrations of the potassium channel opener levcromakalim was measured and the inhibitory effect of glibenclamide on hypoxic and drug induced vasodilatation was analysed."3.69The sensitivity of coronary vascular tone to glibenclamide: a study on the isolated perfused guinea pig heart. ( Cyrys, S; Daut, J, 1994)
" The effects of NG-monomethyl-L-arginine, tetrodotoxin and glibenclamide on hypoxia-induced coronary artery relaxation, induced by bubbling Krebs solution with 95% N2 and 5% CO2 instead of 95% O2 and 5% CO2, were assessed by measuring the changes in isometric tension in isolated epicardial coronary artery rings of the rabbit."3.69Inhibition of hypoxia-induced relaxation of rabbit isolated coronary arteries by NG-monomethyl-L-arginine but not glibenclamide. ( Collins, P; Jiang, C, 1994)
" Hearts were subjected to 15 min of hypoxia followed by reoxygenation in the presence and in the absence of 100 microns glyburide, an ATP-sensitive potassium channel blocker."3.68Influence of ATP-sensitive potassium channel blocker on hypoxia-induced damage of isolated guinea pig heart. ( Branz, AJ; McKean, TA, 1992)
"kg-1 iv 10 min before ischemia or ouabain infusion prevented ventricular fibrillation induced by ischemia in rat and arrhythmias induced by ouabain in guinea pig."3.68Effects of glibenclamide and tolbutamide on ischemia- and ouabain-induced arrhythmias and membrane potentials of ventricular myocardium from rat and guinea pig. ( Fu, SX; Li, YS; Yang, XP; Zhang, HL, 1991)
" The effects of phentolamine (5-30 microM) and glibenclamide (10 microM) on action potential characteristics were examined in guinea-pig papillary muscle exposed to either hypoxia or levcromakalim (20 microM)."3.68Attenuation by phentolamine of hypoxia and levcromakalim-induced abbreviation of the cardiac action potential. ( Boachie-Anash, G; Henderson, CG; Kane, KA; Tweedie, D, 1993)
" In order to determine whether activation of adenosine triphosphate (ATP)-sensitive K+ channels exclusively explains the hypoxia- and ischaemia-induced action potential shortening, effects of tolbutamide and glibenclamide on changes in action potential duration (APD) during hypoxia, metabolic blockade or experimental ischaemia were examined in guinea-pig and canine isolated myocardium by standard microelectrode techniques."3.68Effects of ATP-sensitive K+ channel blockers on the action potential shortening in hypoxic and ischaemic myocardium. ( Kanno, M; Nakaya, H; Takeda, Y; Tohse, N, 1991)
"Hydrogen sulfide (H2S) is a gaseous signaling molecule that appears to be involved in numerous biological processes, including regulation of blood pressure and vascular tone."1.37Hydrogen sulfide and cerebral microvascular tone in newborn pigs. ( Basuroy, S; Fedinec, AL; Jaggar, JH; Leffler, CW; Parfenova, H; Umstot, ES, 2011)
"When samples were subjected to strong hypoxemia using 95% N(2)/5% CO(2), these parameters became even more sensitive to the drug."1.37Glibenclamide reduces proinflammatory cytokines in an ex vivo model of human endotoxinaemia under hypoxaemic conditions. ( Chiba, P; Moravcevic, I; Möslinger, T; Schmid, D; Sorgner, A; Svoboda, M; Thalhammer, T, 2011)
"In LEVO-pretreated hypoxemia, CO was significantly higher compared to unpretreated hypoxemia."1.37The effects of levosimendan and glibenclamide on circulatory and metabolic variables in a canine model of acute hypoxia. ( Picker, O; Schober, P; Schwarte, LA; Schwartges, I; Thomas, K, 2011)
"In fact, severe ischemia reperfusion injury can significantly reduce graft survival, even with modern immunosuppressive agents."1.35Blockade of K(ATP) channels reduces endothelial hyperpolarization and leukocyte recruitment upon reperfusion after hypoxia. ( Chilton, L; Figura, M; Giles, WR; Knight, D; Kubes, P; Liacini, A; Millar, TM; Patel, K; Phan, V; Tibbles, LA; Viskovic, MM, 2009)
"During anoxia, [Ca(2+)](c) increased 9."1.35Mitochondrial ATP-sensitive K+ channels regulate NMDAR activity in the cortex of the anoxic western painted turtle. ( Buck, LT; Cooray, M; Pamenter, ME; Shin, DS, 2008)
"Desflurane or propofol was applied 10 min before and during 10 min of hypoxia (95% nitrogen, 5% carbon dioxide)."1.35Effects of desflurane and propofol on electrophysiological parameters during and recovery after hypoxia in rat hippocampal slice CA1 pyramidal cells. ( Cottrell, JE; Kass, IS; Wang, J, 2009)
"Pretreatment with cromakalim, an opener of K(ATP) channels, occluded the hypoxia-induced hyperpolarization."1.32Effect of acute hypoxia on ATP-sensitive potassium currents in substantia gelatinosa neurons of juvenile rats. ( Jung, SJ; Kim, J; Kwak, J; Lim, W; Park, YK; Yoo, JE, 2003)
"Diazoxide was without effect on tau(open) and tau(closed,fast) but decreased significantly tau(closed,slow) (24."1.31Analysis of single K(ATP) channels in mammalian dentate gyrus granule cells. ( Carlen, PL; Pahapill, PA; Pelletier, MR; Pennefather, PS, 2000)
"During tissue anoxia, elicited by superfusion of N(2)-gassed solution, the biphasic response of the respiratory activity was accompanied by a continuous rise in the IOS."1.31Intrinsic optical signals in respiratory brain stem regions of mice: neurotransmitters, neuromodulators, and metabolic stress. ( Haller, M; Mironov, SL; Richter, DW, 2001)
"Over a 1-h period of anoxia, 59% of Tr cells and 85% Sed cells expressed I(K(ATP))."1.31Exercise training alters an anoxia-induced, glibenclamide-sensitive current in rat ventricular cardiocytes. ( Jew, KN; Moore, RL, 2002)
"Adenosine dilation was also blunted by glibenclamide, a KATP antagonist (9 +/- 2, 14 +/- 3, 21 +/- 4 vs."1.30Role of nitric oxide, cyclic nucleotides, and the activation of ATP-sensitive K+ channels in the contribution of adenosine to hypoxia-induced pial artery dilation. ( Armstead, WM, 1997)
"Exposure to anoxia has been reported to activate ATP-sensitive potassium (K+(ATP)) channels in isolated ventricular myocytes."1.30Anoxia-induced activation of ATP-sensitive K+ channels in guinea pig ventricular cells and its modulation by glycolysis. ( Arita, M; Shigematsu, S, 1997)
"Cromakalim dilation also was not associated with increased CSF cGMP and was unchanged by the Rp diastereomer of 8-bromoguanosine 3',5'-cyclic monophosphothioate, a cGMP antagonist."1.30Relationship among NO, the KATP channel, and opioids in hypoxic pial artery dilation. ( Armstead, WM, 1998)
"The suppression during anoxia (PO2 = 0 mmHg) was approximately 35% (voltage step from -60 to +30 mV) and was due to a combination of several factors: (i) suppression of a cadmium-sensitive, Ca2+-dependent K+ current, IK(CaO2); (ii) suppression of a Ca2+-insensitive, delayed rectifier type K+ current, IK(VO2); (iii) activation of a glibenclamide- (and Ca2+)-sensitive current, IK(ATP)."1.30Anoxia differentially modulates multiple K+ currents and depolarizes neonatal rat adrenal chromaffin cells. ( Nurse, CA; Thompson, RJ, 1998)
"Glibenclamide increased the number of arrhythmias in the normoxic hearts from 1316+/-215 to 2091+/-187 (by 59%) and in the hypoxic group from 636+/-103 to 1777+/-186 (by 179%)."1.30Adaptation to high altitude hypoxia protects the rat heart against ischemia-induced arrhythmias. Involvement of mitochondrial K(ATP) channel. ( Asemu, G; Kolár, F; Ostádal, B; Papousek, F, 1999)
"Acute anoxia or severe hypoxia causes an initial transient contraction followed by marked relaxation of vascular tissues."1.29Critical role of endothelium in sustained arterial contraction during prolonged hypoxia. ( Mehta, JL; Yang, BC, 1995)
"After approximately 8 min anoxia, the KATP current started to rise and reached a maximum of 21."1.29Simultaneous recording of ATP-sensitive K+ current and intracellular Ca2+ in anoxic rat ventricular myocytes. Effects of glibenclamide. ( Englert, H; Gögelein, H; Russ, U; Schölkens, BA, 1996)
"1 ml), and dose-response curves to levcromakalim (a KATP channel opener) or isoproterenol were constructed."1.29Role of potassium channels in hypoxic relaxation of porcine bronchi in vitro. ( Croxton, TL; Fernandes, LB; Hirshman, CA; Lindeman, KS, 1994)
"3."1.28Opposing actions of tolbutamide and glibenclamide on hypoxic pulmonary vasoconstriction. ( Kozlowski, RZ; Nye, PC; Robertson, BE, 1992)
"2."1.28Anoxia induces time-independent K+ current through KATP channels in isolated heart cells of the guinea-pig. ( Benndorf, K; Bollmann, G; Friedrich, M; Hirche, H, 1992)

Research

Studies (136)

TimeframeStudies, this research(%)All Research%
pre-19902 (1.47)18.7374
1990's84 (61.76)18.2507
2000's32 (23.53)29.6817
2010's17 (12.50)24.3611
2020's1 (0.74)2.80

Authors

AuthorsStudies
Maslov, LN1
Sementsov, AS1
Naryzhnaya, NV1
Derkachev, IA1
Fu, F1
Gusakova, SV1
Sarybaev, A1
Lebreton, F1
Berishvili, E1
Parnaud, G1
Rouget, C1
Bosco, D1
Berney, T1
Lavallard, V1
Fukuda, M1
Ando, N1
Sugasawa, Y1
Inoue, R1
Nakauchi, S1
Miura, M2
Nishimura, K1
Yu, L1
Li, W1
Park, BM1
Lee, GJ1
Kim, SH1
Levin, SG1
Shamsutdinova, AA1
Godukhin, OV1
Yuan, F2
Li, HW1
Song, SJ1
Teng, X1
Ma, HJ2
Guo, Z1
Zhang, Y4
Zhou, ZN4
Vollmer, C1
Weiß, S1
Beck, C1
Bauer, I1
Picker, O2
Ma, YC1
Wang, SJ1
Chen, HE1
Huang, LJ1
He, JB1
Wang, Y1
Wang, WT1
Bu, HM1
Yang, CY1
Wang, ML1
Sun, H1
Wang, D1
Liu, Y3
Lu, P1
Zhu, D1
Zhu, Y1
Simard, JM1
Geng, Z1
Woo, SK1
Ivanova, S1
Tosun, C1
Melnichenko, L1
Gerzanich, V1
Wang, J1
Cottrell, JE1
Kass, IS1
Figura, M1
Chilton, L1
Liacini, A1
Viskovic, MM1
Phan, V1
Knight, D1
Millar, TM1
Patel, K1
Kubes, P1
Giles, WR1
Tibbles, LA1
Paddenberg, R1
Faulhammer, P1
Goldenberg, A1
Gries, B1
Heinl, J1
Kummer, W1
Leffler, CW1
Parfenova, H1
Basuroy, S1
Jaggar, JH1
Umstot, ES1
Fedinec, AL1
Schwarte, LA1
Schwartges, I1
Thomas, K1
Schober, P1
Jackson-Weaver, O1
Paredes, DA1
Gonzalez Bosc, LV1
Walker, BR2
Kanagy, NL1
Lin, YK1
Lai, MS1
Chen, YC1
Cheng, CC1
Huang, JH1
Chen, SA1
Chen, YJ1
Lin, CI1
Schmid, D1
Svoboda, M1
Sorgner, A1
Moravcevic, I1
Thalhammer, T1
Chiba, P1
Möslinger, T1
Nakaizumi, A1
Puro, DG1
Gao, L2
Guan, Y1
Cui, F2
Liu, YX1
Dong, ZF1
Kline, DD1
Li, DP1
Weintraub, NL1
Miura, H1
Wachtel, RE1
Loberiza, FR1
Saito, T1
Nicolosi, AC1
Gutterman, DD1
Park, YK1
Jung, SJ1
Yoo, JE1
Kwak, J1
Lim, W1
Kim, J1
Zhu, HF1
Dong, JW1
Zhu, WZ1
Ding, HL1
Kinoshita, H2
Kimoto, Y1
Nakahata, K1
Iranami, H1
Dojo, M1
Hatano, Y1
Bruce, J1
Taggart, M1
Austin, C1
Milano, G1
Bianciardi, P1
Corno, AF1
Raddatz, E1
Morel, S1
von Segesser, LK1
Samaja, M1
Mo, FM1
Ballard, HJ1
Chen, J1
Zhu, JX1
Wilson, I1
Cameron, JS1
López-Valverde, V1
Andersen, CU1
Laursen, BE1
Mulvany, MJ1
Simonsen, U1
Park, WS1
Son, YK1
Kim, N1
Ko, JH1
Kang, SH1
Warda, M1
Earm, YE1
Jung, ID1
Park, YM1
Han, J1
Colantuono, G1
Tiravanti, EA1
Di Venosa, N1
Cazzato, A1
Rastaldo, R1
Cagiano, R1
D'Agostino, D1
Federici, A1
Fiore, T1
Pamenter, ME1
Shin, DS1
Cooray, M1
Buck, LT1
Yang, BC1
Mehta, JL1
Taguchi, H2
Faraci, FM2
Kitazono, T2
Heistad, DD2
Xie, Y1
Zacharias, E1
Hoff, P1
Tegtmeier, F1
Reid, JM2
Davies, AG1
Ashcroft, FM1
Paterson, DJ3
Shankar, V1
Armstead, WM3
Mellemkjaer, S2
Nielsen-Kudsk, JE2
Decking, UK1
Reffelmann, T2
Schrader, J1
Kammermeier, H2
Sawanobori, T1
Adaniya, H1
Yukisada, H1
Hiraoka, M1
Savineau, JP1
Gonzalez de la Fuente, P1
Marthan, R1
Feng, CJ1
Cheng, DY1
Kaye, AD1
Kadowitz, PJ1
Nossaman, BD1
Hara, A1
Abiko, Y1
Cyrys, S1
Daut, J2
Froldi, G1
Pandolfo, L1
Chinellato, A1
Ragazzi, E1
Caparrotta, L1
Fassina, G1
Reeves, WB1
Shah, SV1
Jiang, C2
Collins, P1
Fredricks, KT2
Rusch, NJ3
Lombard, JH3
Marshall, JM3
Thomas, T1
Turner, L1
Loutzenhiser, RD1
Parker, MJ1
Lindeman, KS1
Fernandes, LB2
Croxton, TL1
Hirshman, CA1
Oka, M1
Morris, KG2
McMurtry, IF4
Hong, SJ1
Chang, CC1
Wong, J1
Vanderford, PA1
Fineman, JR1
Chang, R1
Soifer, SJ1
Greenberg, B1
Kishiyama, S1
MacKenzie, I1
Saville, VL1
Waterfall, JF1
Eddahibi, S1
Springall, D1
Mannan, M1
Carville, C1
Chabrier, PE1
Levame, M1
Raffestin, B1
Polak, J1
Adnot, S1
Tweedie, D1
Boachie-Anash, G1
Henderson, CG1
Kane, KA1
Smirnov, SV1
Robertson, TP1
Ward, JP1
Aaronson, PI1
Takata, Y1
Shimada, F1
Kato, H1
Kalsner, S1
Eichinger, MR1
Resta, TC1
Balderrama, DS1
Herrera, GM1
Richardson, LA1
Resta, JM1
Yabe, K1
Nasa, Y1
Takeo, S2
Russ, U1
Englert, H1
Schölkens, BA1
Gögelein, H1
Cornfield, DN1
Reeve, HL1
Tolarova, S1
Weir, EK1
Archer, S2
Vallet, B1
Guery, B1
Mangalaboyi, J1
Menager, P1
Curtis, SE1
Cain, SM1
Chopin, C1
Dupuis, BA1
Wanstall, JC1
O'Brien, E1
Pierrefiche, O1
Bischoff, AM1
Richter, DW3
Shigemori, K1
Ishizaki, T1
Matsukawa, S1
Sakai, A1
Nakai, T1
Miyabo, S1
Wu, CW1
Leung, CK1
Yung, WH1
Hüsken, BC1
Pfaffendorf, M1
van Zwieten, PA1
Baker, JE4
Curry, BD1
Olinger, GN1
Gross, GJ4
Gauthier-Rein, KM1
Bizub, DM2
Contney, SJ2
Bosnjak, ZJ2
Boels, PJ1
Gao, B1
Deutsch, J1
Haworth, SG2
Shivkumar, K1
Deutsch, NA1
Lamp, ST2
Khuu, K1
Goldhaber, JI1
Weiss, JN2
Shigematsu, S1
Arita, M1
Bari, F1
Louis, TM1
Busija, DW1
Mironov, SL2
Langohr, K1
Haller, M2
Van Lunteren, E1
Moyer, M1
Torres, A1
Barman, SA1
Evans, AM1
Osipenko, ON1
Gurney, AM1
Jovanovic, A1
Jovanovic, S1
Carrasco, AJ1
Terzic, A1
Thompson, RJ1
Nurse, CA1
Bryan, PT1
Pék-Scott, M1
Lutz, PL1
Roman, RJ1
Golanov, EV1
Reis, DJ1
Dumas, JP1
Goirand, F2
Bardou, M2
Dumas, M2
Rochette, L2
Advenier, C1
Giudicelli, JF1
Picard, S1
Criniti, A1
Iwashiro, K1
Rouet, R1
Monti, F1
Tonelli, E1
Ruvolo, G1
Ducouret, P1
del Monte, F1
Papalia, U1
Puddu, PE1
Tomiyama, Y1
Brian, JE1
Todd, MM1
Fukuda, S1
Toriumi, T1
Xu, H1
Nishimaki, H1
Kokubun, S1
Fujiwara, N1
Fujihara, H1
Shimoji, K1
Tanonaka, K1
Taguchi, T1
Koshimizu, M1
Ando, T1
Morinaka, T1
Yogo, T1
Konishi, F1
Asemu, G1
Papousek, F1
Ostádal, B1
Kolár, F1
Sato, K1
Morio, Y1
Rodman, DM3
Mohan, RM1
Michelakis, E1
Rebeyka, I1
Bateson, J1
Olley, P1
Puttagunta, L1
Pelletier, MR1
Pahapill, PA1
Pennefather, PS1
Carlen, PL1
Eells, JT1
Henry, MM1
Singh, R1
Kalyanaraman, B1
Dumas, J1
Ambalavanan, N1
Bulger, A1
Ware, J1
Philips, J1
Skobel, EC1
Hanrath, P1
Schwarz, ER1
Smani, T1
Hernández, A1
Ureña, J1
Castellano, AG1
Franco-Obregón, A1
Ordoñez, A1
López-Barneo, J1
Bartlett, IS1
Kerkhof, CJ1
Van Der Linden, PJ1
Sipkema, P1
Jew, KN1
Moore, RL1
MacCormack, TJ1
Driedzic, WR1
Robertson, BE1
Kozlowski, RZ1
Nye, PC1
McKean, TA1
Branz, AJ1
Benndorf, K1
Bollmann, G1
Friedrich, M1
Hirche, H1
Spina, D1
Preuss, JM1
Hay, DW1
Muccitelli, RM1
Page, CP1
Goldie, RG1
Trezise, DJ1
Weston, AH1
Zhang, HL1
Li, YS1
Fu, SX1
Yang, XP1
Hasunuma, K2
Yamaguchi, T1
O'Brien, RF1
Carmeliet, E1
Wiener, CM1
Dunn, A1
Sylvester, JT1
Nakaya, H1
Takeda, Y1
Tohse, N1
Kanno, M1
Deutsch, N1
Klitzner, TS1
Haddad, GG1
Maier-Rudolph, W1
von Beckerath, N1
Mehrke, G1
Günther, K1
Goedel-Meinen, L1
Yuan, XJ1
Tod, ML1
Rubin, LJ1
Blaustein, MP1
Wilde, AA1
Escande, D1
Schumacher, CA1
Thuringer, D1
Mestre, M1
Fiolet, JW1
Janse, MJ1
Krnjević, K1
Peach, JL1
Sanguinetti, MC1
Scott, AL1
Zingaro, GJ1
Siegl, PK1
Ben Ari, Y1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Liberal Versus Restrictive Platelet Transfusion for Treatment of Hemodynamically Significant Patent Ductus Arteriosus in Thrombocytopenic Preterm Neonates- A Randomized Open Label, Controlled Trial[NCT03022253]Phase 344 participants (Anticipated)Interventional2016-03-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

136 other studies available for glyburide and Anoxemia

ArticleYear
The Role of Mitochondrial K
    Bulletin of experimental biology and medicine, 2022, Volume: 174, Issue:2

    Topics: Adenosine Triphosphate; Animals; Glyburide; Hypoxia; KATP Channels; Male; Myocardial Infarction; Rat

2022
NLRP3 inflammasome is expressed and regulated in human islets.
    Cell death & disease, 2018, 06-25, Volume: 9, Issue:7

    Topics: Cell Death; Gene Expression Regulation; Glyburide; Humans; Hypoxia; Inflammasomes; Interleukin-1beta

2018
Volatile anesthetic sevoflurane pretreatment alleviates hypoxia-induced potentiation of excitatory inputs to striatal medium spiny neurons of mice.
    The European journal of neuroscience, 2019, Volume: 50, Issue:9

    Topics: Action Potentials; Animals; Central Nervous System Sensitization; Corpus Striatum; Coumaric Acids; E

2019
Hypoxia augments NaHS-induced ANP secretion via KATP channel, HIF-1α and PPAR-γ pathway.
    Peptides, 2019, Volume: 121

    Topics: 2-Methoxyestradiol; Anilides; Animals; Atrial Natriuretic Factor; Bosentan; Gene Expression Regulati

2019
Comparison of effects of ATP-gated potassium channel blockers on activity variations of rat CA1 pyramidal neurons in hippocampal slices triggered by short-term hypoxia.
    Bulletin of experimental biology and medicine, 2013, Volume: 154, Issue:4

    Topics: Animals; Decanoic Acids; Glyburide; Hippocampus; Hydroxy Acids; Hypoxia; Male; Potassium Channel Blo

2013
Opioid receptors mediate enhancement of ACh-induced aorta relaxation by chronic intermittent hypobaric hypoxia.
    Sheng li xue bao : [Acta physiologica Sinica], 2013, Jun-25, Volume: 65, Issue:3

    Topics: Acetylcholine; Altitude; Animals; Aorta, Thoracic; Glyburide; Hypoxia; KATP Channels; Male; Rats; Ra

2013
Hypothermia improves oral and gastric mucosal oxygenation during hypoxic challenges.
    British journal of anaesthesia, 2014, Volume: 113, Issue:3

    Topics: Animals; Cardiac Output; Cardiotonic Agents; Cross-Over Studies; Disease Models, Animal; Dogs; Femal

2014
[Glybenclamide regulate ERK1/2 signal pathway during hypoxia hypercapnia pulmonary vasoconstriction in rats].
    Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology, 2014, Volume: 30, Issue:2

    Topics: Animals; Glyburide; Hypercapnia; Hypoxia; In Vitro Techniques; Male; MAP Kinase Signaling System; Pu

2014
K(ATP) channels and MPTP are involved in the cardioprotection bestowed by chronic intermittent hypobaric hypoxia in the developing rat.
    The journal of physiological sciences : JPS, 2015, Volume: 65, Issue:4

    Topics: Animals; Atmospheric Pressure; Atractyloside; Cardiotonic Agents; Cyclosporine; Decanoic Acids; Diaz

2015
15-oxo-ETE-induced internal carotid artery constriction in hypoxic rats is mediated by potassium channels.
    Physiological research, 2016, 07-18, Volume: 65, Issue:3

    Topics: 4-Aminopyridine; Animals; Arachidonic Acids; Carotid Artery, Internal; Glyburide; Hydroxyprostagland

2016
Glibenclamide reduces inflammation, vasogenic edema, and caspase-3 activation after subarachnoid hemorrhage.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2009, Volume: 29, Issue:2

    Topics: Animals; ATP-Binding Cassette Transporters; Blood-Brain Barrier; Brain Edema; Carotid Artery Injurie

2009
Effects of desflurane and propofol on electrophysiological parameters during and recovery after hypoxia in rat hippocampal slice CA1 pyramidal cells.
    Neuroscience, 2009, Apr-21, Volume: 160, Issue:1

    Topics: Action Potentials; Animals; Benzophenanthridines; Desflurane; Dose-Response Relationship, Drug; Enzy

2009
Blockade of K(ATP) channels reduces endothelial hyperpolarization and leukocyte recruitment upon reperfusion after hypoxia.
    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2009, Volume: 9, Issue:4

    Topics: Animals; Cats; Cell Membrane; Endothelium, Vascular; Gelatin; Glyburide; Humans; Hypoxia; KATP Chann

2009
Impact of modulators of mitochondrial ATP-sensitive potassium channel (mitoK(ATP)) on hypoxic pulmonary vasoconstriction.
    Advances in experimental medicine and biology, 2009, Volume: 648

    Topics: Animals; Arteries; Coronary Vessels; Decanoic Acids; Glyburide; Heart; Hydroxy Acids; Hypoxia; Immun

2009
Hydrogen sulfide and cerebral microvascular tone in newborn pigs.
    American journal of physiology. Heart and circulatory physiology, 2011, Volume: 300, Issue:2

    Topics: Animals; Animals, Newborn; Arterioles; Brain Chemistry; Capillaries; Cerebrovascular Circulation; Cy

2011
The effects of levosimendan and glibenclamide on circulatory and metabolic variables in a canine model of acute hypoxia.
    Intensive care medicine, 2011, Volume: 37, Issue:4

    Topics: Acute Disease; Adenosine Triphosphate; Animals; Dogs; Glyburide; Hemodynamics; Hydrazones; Hypoglyce

2011
Intermittent hypoxia in rats increases myogenic tone through loss of hydrogen sulfide activation of large-conductance Ca(2+)-activated potassium channels.
    Circulation research, 2011, Jun-10, Volume: 108, Issue:12

    Topics: 1-Methyl-3-isobutylxanthine; Air Pollutants; Animals; Blood Pressure; Endothelium, Vascular; Glyburi

2011
Hypoxia and reoxygenation modulate the arrhythmogenic activity of the pulmonary vein and atrium.
    Clinical science (London, England : 1979), 2012, Volume: 122, Issue:3

    Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Atrial Fibrillation; Blotting, Western; Chloramphe

2012
Glibenclamide reduces proinflammatory cytokines in an ex vivo model of human endotoxinaemia under hypoxaemic conditions.
    Life sciences, 2011, Nov-07, Volume: 89, Issue:19-20

    Topics: Adult; Anti-Inflammatory Agents; Calcium; Cytokines; Dose-Response Relationship, Drug; Endotoxemia;

2011
Vulnerability of the retinal microvasculature to hypoxia: role of polyamine-regulated K(ATP) channels.
    Investigative ophthalmology & visual science, 2011, Dec-09, Volume: 52, Issue:13

    Topics: Animals; Apoptosis; Disease Models, Animal; Eflornithine; Glyburide; Hypoxia; Ion Transport; KATP Ch

2011
Facilitation of chronic intermittent hypobaric hypoxia on carotid sinus baroreflex in anesthetized rats.
    The Chinese journal of physiology, 2012, Feb-29, Volume: 55, Issue:1

    Topics: Anesthesia; Animals; Baroreflex; Blood Gas Analysis; Blood Pressure; Body Weight; Carotid Sinus; Gly

2012
Hypobaric intermittent hypoxia attenuates hypoxia-induced depressor response.
    PloS one, 2012, Volume: 7, Issue:7

    Topics: Altitude; Animals; Baroreflex; Blood Pressure; Environment, Controlled; Glyburide; Heart Rate; Hypox

2012
Impaired hypoxic coronary vasodilation and ATP-sensitive potassium channel function: a manifestation of diabetic microangiopathy in humans?
    Circulation research, 2003, Feb-07, Volume: 92, Issue:2

    Topics: Adenosine Triphosphate; Coronary Vessels; Diabetic Angiopathies; Glyburide; Humans; Hypoxia; Microci

2003
Diabetes mellitus impairs vasodilation to hypoxia in human coronary arterioles: reduced activity of ATP-sensitive potassium channels.
    Circulation research, 2003, Feb-07, Volume: 92, Issue:2

    Topics: Adenosine Triphosphate; Age Factors; Arterioles; Bradykinin; Coronary Vessels; Diabetes Mellitus; Fe

2003
Effect of acute hypoxia on ATP-sensitive potassium currents in substantia gelatinosa neurons of juvenile rats.
    Pflugers Archiv : European journal of physiology, 2003, Volume: 446, Issue:5

    Topics: Acute Disease; Adenosine Triphosphate; Age Factors; Animals; Anti-Arrhythmia Agents; Barium; Cesium;

2003
ATP-dependent potassium channels involved in the cardiac protection induced by intermittent hypoxia against ischemia/reperfusion injury.
    Life sciences, 2003, Jul-25, Volume: 73, Issue:10

    Topics: Animals; Calcium; Decanoic Acids; Glyburide; Heart Ventricles; Hemodynamics; Hydroxy Acids; Hypoxia;

2003
The role of K+ channels in vasorelaxation induced by hypoxia and the modulator effects of lidocaine in the rat carotid artery.
    Anesthesia and analgesia, 2003, Volume: 97, Issue:2

    Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Carotid Artery, Common; Cromakalim; Dose-Re

2003
Contractile responses of isolated rat mesenteric arteries to acute episodes of severe hypoxia and subsequent reoxygenation.
    Microvascular research, 2004, Volume: 68, Issue:3

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 4-Aminopyridine; Adenosine Triph

2004
Myocardial impairment in chronic hypoxia is abolished by short aeration episodes: involvement of K+ATP channels.
    Experimental biology and medicine (Maywood, N.J.), 2004, Volume: 229, Issue:11

    Topics: Animals; Apoptosis; Chronic Disease; Glyburide; Heart; Hypoxia; In Situ Nick-End Labeling; Male; Myo

2004
Acute systemic hypoxia elevates venous but not interstitial potassium of dog skeletal muscle.
    American journal of physiology. Heart and circulatory physiology, 2005, Volume: 289, Issue:4

    Topics: Acute Disease; Adenosine Triphosphate; Animals; Carbon Dioxide; Dogs; Female; Glyburide; Hydrogen-Io

2005
Cardioprotective effects of K ATP channel activation during hypoxia in goldfish Carassius auratus.
    The Journal of experimental biology, 2005, Volume: 208, Issue:Pt 14

    Topics: Acclimatization; Action Potentials; Analysis of Variance; Animals; Cyclic GMP; Diazoxide; Glyburide;

2005
Glibenclamide reveals role for endothelin in hypoxia-induced vasoconstriction in rat intrapulmonary arteries.
    Journal of cardiovascular pharmacology, 2005, Volume: 46, Issue:4

    Topics: Animals; Anti-Arrhythmia Agents; Carboxylic Acids; Dose-Response Relationship, Drug; Endothelin Rece

2005
Acute hypoxia induces vasodilation and increases coronary blood flow by activating inward rectifier K(+) channels.
    Pflugers Archiv : European journal of physiology, 2007, Volume: 454, Issue:6

    Topics: Acute Disease; Adenine; Animals; Blood Pressure; Carbazoles; Coronary Circulation; Cyclic AMP-Depend

2007
Hyperoxia confers myocardial protection in mechanically ventilated rats through the generation of free radicals and opening of mitochondrial ATP-sensitive potassium channels.
    Clinical and experimental pharmacology & physiology, 2008, Volume: 35, Issue:1

    Topics: Acetylcysteine; Animals; Blood Pressure; Coronary Circulation; Decanoic Acids; Disease Models, Anima

2008
Mitochondrial ATP-sensitive K+ channels regulate NMDAR activity in the cortex of the anoxic western painted turtle.
    The Journal of physiology, 2008, Feb-15, Volume: 586, Issue:4

    Topics: Adenosine Triphosphate; Animals; Calcium; Cerebral Cortex; Cromakalim; Decanoic Acids; Diazoxide; Gl

2008
Critical role of endothelium in sustained arterial contraction during prolonged hypoxia.
    The American journal of physiology, 1995, Volume: 268, Issue:3 Pt 2

    Topics: Adenosine Triphosphate; Amino Acid Oxidoreductases; Animals; Aorta, Thoracic; Arginine; Endothelium,

1995
Relaxation of the aorta during hypoxia is impaired in chronically hypertensive rats.
    Hypertension (Dallas, Tex. : 1979), 1995, Volume: 25, Issue:4 Pt 2

    Topics: Animals; Aorta; Charybdotoxin; Chronic Disease; Glyburide; Hypertension; Hypoxia; Male; Nitroprussid

1995
Ion channel involvement in anoxic depolarization induced by cardiac arrest in rat brain.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1995, Volume: 15, Issue:4

    Topics: Adenosine Triphosphate; Animals; Benzothiazoles; Calcium; Dizocilpine Maleate; Flunarizine; Glyburid

1995
Effect of L-NMMA, cromakalim, and glibenclamide on cerebral blood flow in hypercapnia and hypoxia.
    The American journal of physiology, 1995, Volume: 269, Issue:3 Pt 2

    Topics: Animals; Arginine; Arteries; Benzopyrans; Cerebrovascular Circulation; Cromakalim; Glyburide; Hyperc

1995
Opioids contribute to hypoxia-induced pial artery dilation through activation of ATP-sensitive K+ channels.
    The American journal of physiology, 1995, Volume: 269, Issue:3 Pt 2

    Topics: Adenosine Triphosphate; Animals; Blood Pressure; Blood Vessels; Female; Glyburide; Hypoxia; Male; Na

1995
Effects of levcromakalim and glibenclamide on paced guinea-pig atrial strips exposed to hypoxia.
    European journal of pharmacology, 1995, Apr-13, Volume: 277, Issue:1

    Topics: Animals; Benzopyrans; Cardiac Pacing, Artificial; Cromakalim; Deoxyglucose; Dose-Response Relationsh

1995
Hypoxia-induced activation of KATP channels limits energy depletion in the guinea pig heart.
    The American journal of physiology, 1995, Volume: 269, Issue:2 Pt 2

    Topics: Adenosine Triphosphate; Animals; Energy Metabolism; Female; Glyburide; Guinea Pigs; Hypoxia; Myocard

1995
Role for ATP-sensitive K+ channel in the development of A-V block during hypoxia.
    Journal of molecular and cellular cardiology, 1995, Volume: 27, Issue:1

    Topics: Action Potentials; Adenosine Triphosphate; Animals; Atrioventricular Node; Deoxyglucose; Female; Glu

1995
Cellular mechanisms of hypoxia-induced contraction in human and rat pulmonary arteries.
    Respiration physiology, 1995, Volume: 99, Issue:2

    Topics: Aged; Animals; Benzopyrans; Calcium; Calcium Channels; Cromakalim; Glyburide; Humans; Hypoxia; In Vi

1995
Glibenclamide inhibits hypoxic relaxation of isolated porcine coronary arteries under conditions of impaired glycolysis.
    European journal of pharmacology, 1994, Aug-03, Volume: 270, Issue:4

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Triphosphate; Animals;

1994
Influence of N omega-nitro-L-arginine methyl ester, LY83583, glybenclamide and L158809 on pulmonary circulation.
    European journal of pharmacology, 1994, Sep-22, Volume: 263, Issue:1-2

    Topics: Aminoquinolines; Angiotensin Receptor Antagonists; Animals; Arginine; Drug Interactions; Glyburide;

1994
Protective effect of hypoxia on mechanical and metabolic changes induced by hydrogen peroxide in rat hearts.
    The American journal of physiology, 1995, Volume: 268, Issue:2 Pt 2

    Topics: Animals; Glyburide; Heart; Hydrogen Peroxide; Hypoxia; In Vitro Techniques; Male; Myocardium; Purine

1995
The sensitivity of coronary vascular tone to glibenclamide: a study on the isolated perfused guinea pig heart.
    Cardiovascular research, 1994, Volume: 28, Issue:6

    Topics: Animals; Benzopyrans; Biological Assay; Coronary Vessels; Cromakalim; Glyburide; Guinea Pigs; Hypoxi

1994
Protection of atrial function in hypoxia by high potassium concentration.
    General pharmacology, 1994, Volume: 25, Issue:3

    Topics: Adenine Nucleotides; Animals; Cardiac Pacing, Artificial; Diastole; Energy Metabolism; Evaluation St

1994
Activation of potassium channels contributes to hypoxic injury in proximal tubules.
    The Journal of clinical investigation, 1994, Volume: 94, Issue:6

    Topics: Adenosine Triphosphate; Animals; Biological Transport; Diazoxide; DNA Damage; Dose-Response Relation

1994
Inhibition of hypoxia-induced relaxation of rabbit isolated coronary arteries by NG-monomethyl-L-arginine but not glibenclamide.
    British journal of pharmacology, 1994, Volume: 111, Issue:3

    Topics: Adenosine; Adenosine Triphosphate; Animals; Arginine; Capsaicin; Coronary Vessels; Endothelium, Vasc

1994
Role of endothelium and arterial K+ channels in mediating hypoxic dilation of middle cerebral arteries.
    The American journal of physiology, 1994, Volume: 267, Issue:2 Pt 2

    Topics: Animals; Cerebral Arteries; Endothelium, Vascular; Glyburide; Hypoxia; In Vitro Techniques; Male; Ox

1994
A link between adenosine, ATP-sensitive K+ channels, potassium and muscle vasodilatation in the rat in systemic hypoxia.
    The Journal of physiology, 1993, Volume: 472

    Topics: 2-Chloroadenosine; Adenosine; Adenosine Triphosphate; Animals; Glyburide; Hypoxia; Muscles; Potassiu

1993
ATP-sensitive K+ channels mediate dilatation of cerebral arterioles during hypoxia.
    Circulation research, 1994, Volume: 74, Issue:5

    Topics: Adenosine; Adenosine Triphosphate; Animals; Arterioles; Brain; Glyburide; Hypoxia; Male; Picolines;

1994
Hypoxia inhibits myogenic reactivity of renal afferent arterioles by activating ATP-sensitive K+ channels.
    Circulation research, 1994, Volume: 74, Issue:5

    Topics: Adenosine Triphosphate; Animals; Arterioles; Glyburide; Hypoxia; Kidney; NAD; Potassium Channels; Ra

1994
Role of potassium channels in hypoxic relaxation of porcine bronchi in vitro.
    The American journal of physiology, 1994, Volume: 266, Issue:3 Pt 1

    Topics: Animals; Benzopyrans; Bronchi; Bronchodilator Agents; Carbachol; Cromakalim; Dose-Response Relations

1994
NIP-121 is more effective than nifedipine in acutely reversing chronic pulmonary hypertension.
    Journal of applied physiology (Bethesda, Md. : 1985), 1993, Volume: 75, Issue:3

    Topics: Altitude; Animals; Chronic Disease; Glyburide; Hemodynamics; Hypertension, Pulmonary; Hypoxia; Male;

1993
O2 occlusion and cyanide induced immediate relaxation and contraction of murine skeletal muscle.
    Neuroscience letters, 1993, Aug-06, Volume: 158, Issue:1

    Topics: Animals; Caffeine; Cyanides; Electric Stimulation; Glyburide; Hypoxia; In Vitro Techniques; Mice; Mi

1993
Endothelin-1 produces pulmonary vasodilation in the intact newborn lamb.
    The American journal of physiology, 1993, Volume: 265, Issue:4 Pt 2

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Animals, Newborn; Argin

1993
Endothelium-dependent and -independent responses to severe hypoxia in rat pulmonary artery.
    The American journal of physiology, 1993, Volume: 265, Issue:5 Pt 2

    Topics: Acetylcholine; Animals; Arginine; Endothelium, Vascular; Glyburide; Hemoglobins; Hypoxia; In Vitro T

1993
Differential class III and glibenclamide effects on action potential duration in guinea-pig papillary muscle during normoxia and hypoxia/ischaemia.
    British journal of pharmacology, 1993, Volume: 110, Issue:2

    Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Electrophysiology; Glyburide; Guinea Pigs; Heart

1993
Dilator effect of endothelins in pulmonary circulation: changes associated with chronic hypoxia.
    The American journal of physiology, 1993, Volume: 265, Issue:6 Pt 1

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Arginine; Autoradiograp

1993
Attenuation by phentolamine of hypoxia and levcromakalim-induced abbreviation of the cardiac action potential.
    British journal of pharmacology, 1993, Volume: 110, Issue:3

    Topics: Action Potentials; Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Drug Interactions; Gluc

1993
Chronic hypoxia is associated with reduced delayed rectifier K+ current in rat pulmonary artery muscle cells.
    The American journal of physiology, 1994, Volume: 266, Issue:1 Pt 2

    Topics: 4-Aminopyridine; Animals; Chronic Disease; Electric Conductivity; Electrophysiology; Glyburide; Hypo

1994
Possible involvement of ATP-sensitive K+ channels in the inhibition of rat central adrenergic neurotransmission under hypoxia.
    Japanese journal of pharmacology, 1993, Volume: 62, Issue:3

    Topics: Adenosine Triphosphate; Animals; Cocaine; Dose-Response Relationship, Drug; Glyburide; Hypoxia; In V

1993
Hypoxic relaxation in functionally intact cattle coronary artery segments involves K+ ATP channels.
    The Journal of pharmacology and experimental therapeutics, 1995, Volume: 275, Issue:3

    Topics: Adenosine; Adenosine Triphosphate; Animals; Arteries; Calcium; Calcium Channel Blockers; Cattle; Cor

1995
Glibenclamide does not reverse attenuated vasoreactivity to acute or chronic hypoxia.
    Journal of applied physiology (Bethesda, Md. : 1985), 1995, Volume: 79, Issue:4

    Topics: Acute Disease; Adenosine Triphosphate; Animals; Benzopyrans; Blood Gas Analysis; Blood Pressure; Chr

1995
Hypoxic preconditioning in isolated rat hearts: non-involvement of activation of adenosine A1 receptor, Gi protein, and ATP-sensitive K+ channel.
    Heart and vessels, 1995, Volume: 10, Issue:6

    Topics: Adenosine Triphosphate; Analysis of Variance; Animals; Calcium Channel Blockers; Creatine Kinase; Gl

1995
Simultaneous recording of ATP-sensitive K+ current and intracellular Ca2+ in anoxic rat ventricular myocytes. Effects of glibenclamide.
    Pflugers Archiv : European journal of physiology, 1996, Volume: 432, Issue:1

    Topics: Adenosine Triphosphate; Animals; Calcium; Cyanides; Electric Conductivity; Fura-2; Glyburide; Hypoxi

1996
Oxygen causes fetal pulmonary vasodilation through activation of a calcium-dependent potassium channel.
    Proceedings of the National Academy of Sciences of the United States of America, 1996, Jul-23, Volume: 93, Issue:15

    Topics: Alkaloids; Aminoquinolines; Animals; Carbazoles; Charybdotoxin; Endothelium, Vascular; Enzyme Inhibi

1996
Role of K+ in regulating hypoxic cerebral blood flow in the rat: effect of glibenclamide and ouabain.
    The American journal of physiology, 1996, Volume: 270, Issue:1 Pt 2

    Topics: Animals; Blood Pressure; Brain Ischemia; Cerebrovascular Circulation; Extracellular Space; Female; G

1996
Critical oxygen extraction in piglet hindlimb is impaired after inhibition of ATP-sensitive potassium channels.
    Advances in experimental medicine and biology, 1996, Volume: 388

    Topics: Adenosine Triphosphate; Animals; Glyburide; Hindlimb; Hypoxia; Ischemia; Muscle, Smooth, Vascular; O

1996
In vitro hypoxia on rat pulmonary artery: effects on contractions to spasmogens and role of KATP channels.
    European journal of pharmacology, 1996, May-06, Volume: 303, Issue:1-2

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Benzopyrans; Cromakalim

1996
ATP-sensitive K+ channels are functional in expiratory neurones of normoxic cats.
    The Journal of physiology, 1996, Jul-15, Volume: 494 ( Pt 2)

    Topics: Adenosine Triphosphate; Animals; Bicuculline; Blood-Brain Barrier; Brain Stem; Cats; Female; Glyburi

1996
Adenine nucleotides via activation of ATP-sensitive K+ channels modulate hypoxic response in rat pulmonary artery.
    The American journal of physiology, 1996, Volume: 270, Issue:5 Pt 1

    Topics: Adenine Nucleotides; Adenosine Triphosphate; Animals; Glyburide; Hyperglycemia; Hypoglycemic Agents;

1996
Role of nitric oxide, cyclic nucleotides, and the activation of ATP-sensitive K+ channels in the contribution of adenosine to hypoxia-induced pial artery dilation.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1997, Volume: 17, Issue:1

    Topics: Adenosine; Adenosine Deaminase; Adenosine Triphosphate; Animals; Arteries; Blood Pressure; Cyclic AM

1997
Sulphonylureas reverse hypoxia induced K(+)-conductance increase in substantia nigra pars reticulata neurones.
    Neuroreport, 1996, Nov-04, Volume: 7, Issue:15-17

    Topics: Animals; Glyburide; Hypoxia; Membrane Potentials; Potassium Channels; Rats; Substantia Nigra; Tetrod

1996
ATP-sensitive potassium channels in isolated rat aorta during physiologic, hypoxic, and low-glucose conditions.
    Journal of cardiovascular pharmacology, 1997, Volume: 29, Issue:1

    Topics: Adenosine Triphosphate; Animals; Aorta, Thoracic; Benzopyrans; Cromakalim; Dose-Response Relationshi

1997
Increased tolerance of the chronically hypoxic immature heart to ischemia. Contribution of the KATP channel.
    Circulation, 1997, Mar-04, Volume: 95, Issue:5

    Topics: Analysis of Variance; Animals; Animals, Newborn; Benzopyrans; Coronary Circulation; Dihydropyridines

1997
Hypoxia-induced hyperpolarization is not associated with vasodilation of bovine coronary resistance arteries.
    The American journal of physiology, 1997, Volume: 272, Issue:3 Pt 2

    Topics: Acetylcholine; Animals; Benzopyrans; Bradykinin; Calcium; Cattle; Coronary Vessels; Cromakalim; Endo

1997
KATP channel activation in a rabbit model of chronic myocardial hypoxia.
    Journal of molecular and cellular cardiology, 1997, Volume: 29, Issue:2

    Topics: Action Potentials; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Animals, Newborn; Chronic

1997
ATP-dependent K+ channel activation in isolated normal and hypertensive newborn and adult porcine pulmonary vessels.
    Pediatric research, 1997, Volume: 42, Issue:3

    Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Antihypertensive Agents; Cromakalim; Cyclooxygena

1997
Mechanism of hypoxic K loss in rabbit ventricle.
    The Journal of clinical investigation, 1997, Oct-01, Volume: 100, Issue:7

    Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Biological Transport; Cromakalim; Glyburide; Heart

1997
Anoxia-induced activation of ATP-sensitive K+ channels in guinea pig ventricular cells and its modulation by glycolysis.
    Cardiovascular research, 1997, Volume: 35, Issue:2

    Topics: Action Potentials; Adenosine Triphosphate; Animals; Glyburide; Glycolysis; Guinea Pigs; Hypoxia; Ion

1997
Effects of ischemia on cerebral arteriolar dilation to arterial hypoxia in piglets.
    Stroke, 1998, Volume: 29, Issue:1

    Topics: Adenosine; Adenosine Triphosphate; Administration, Topical; Analysis of Variance; Animals; Arteriole

1998
Hypoxia activates ATP-dependent potassium channels in inspiratory neurones of neonatal mice.
    The Journal of physiology, 1998, Jun-15, Volume: 509 ( Pt 3)

    Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Calcium; Diazoxide; Electric Stimulation; Glyburi

1998
ATP-sensitive K+ channel blocker glibenclamide and diaphragm fatigue during normoxia and hypoxia.
    Journal of applied physiology (Bethesda, Md. : 1985), 1998, Volume: 85, Issue:2

    Topics: Adenosine Triphosphate; Animals; Diaphragm; Electric Stimulation; Glyburide; Hypoglycemic Agents; Hy

1998
Potassium channels modulate hypoxic pulmonary vasoconstriction.
    The American journal of physiology, 1998, Volume: 275, Issue:1

    Topics: 4-Aminopyridine; Animals; Blood Pressure; Dogs; Female; Glyburide; Hypoxia; In Vitro Techniques; Mal

1998
Resting potentials and potassium currents during development of pulmonary artery smooth muscle cells.
    The American journal of physiology, 1998, Volume: 275, Issue:3

    Topics: Aging; Animals; Animals, Newborn; Calcium; Electric Conductivity; Glyburide; Hypoxia; Membrane Poten

1998
Relationship among NO, the KATP channel, and opioids in hypoxic pial artery dilation.
    The American journal of physiology, 1998, Volume: 275, Issue:3

    Topics: Adenosine Triphosphate; Animals; Arteries; Blood Pressure; Calcitonin Gene-Related Peptide; Cromakal

1998
Acquired resistance of a mammalian cell line to hypoxia-reoxygenation through cotransfection of Kir6.2 and SUR1 clones.
    Laboratory investigation; a journal of technical methods and pathology, 1998, Volume: 78, Issue:9

    Topics: Animals; Calcium; COS Cells; Genetic Predisposition to Disease; Glyburide; Glycosyltransferases; Hyp

1998
Anoxia differentially modulates multiple K+ currents and depolarizes neonatal rat adrenal chromaffin cells.
    The Journal of physiology, 1998, Oct-15, Volume: 512 ( Pt 2)

    Topics: Animals; Animals, Newborn; Chromaffin Cells; Electric Stimulation; Electrophysiology; Glyburide; Hyp

1998
Cellular mechanisms by which adenosine induces vasodilatation in rat skeletal muscle: significance for systemic hypoxia.
    The Journal of physiology, 1999, Jan-01, Volume: 514 ( Pt 1)

    Topics: Adenosine; Animals; Antihypertensive Agents; Blood Pressure; Cromakalim; Enzyme Inhibitors; Femoral

1999
ATP-sensitive K+ channel activation provides transient protection to the anoxic turtle brain.
    The American journal of physiology, 1998, Volume: 275, Issue:6

    Topics: Adenosine Triphosphate; Animals; Brain; Diacetyl; Extracellular Space; Glyburide; Hypoxia; Ouabain;

1998
Electrical and mechanical responses of rat middle cerebral arteries to reduced PO2 and prostacyclin.
    The American journal of physiology, 1999, Volume: 276, Issue:2

    Topics: Animals; Cerebral Arteries; Electrophysiology; Epoprostenol; Glyburide; Hypoxia; Iloprost; In Vitro

1999
A role for KATP+-channels in mediating the elevations of cerebral blood flow and arterial pressure by hypoxic stimulation of oxygen-sensitive neurons of rostral ventrolateral medulla.
    Brain research, 1999, May-08, Volume: 827, Issue:1-2

    Topics: Adenosine Triphosphate; Animals; Blood Pressure; Brain Chemistry; Cerebrovascular Circulation; Glybu

1999
Role of potassium channels and nitric oxide in the relaxant effects elicited by beta-adrenoceptor agonists on hypoxic vasoconstriction in the isolated perfused lung of the rat.
    British journal of pharmacology, 1999, Volume: 127, Issue:2

    Topics: Adrenergic beta-Agonists; Animals; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Glyburide; Hypoxia;

1999
Protection of human myocardium in vitro by K(ATP) activation with low concentrations of bimakalim.
    Journal of cardiovascular pharmacology, 1999, Volume: 34, Issue:1

    Topics: Adenosine Triphosphate; Adult; Benzopyrans; Dihydropyridines; Dobutamine; Dose-Response Relationship

1999
Cerebral blood flow during hemodilution and hypoxia in rats : role of ATP-sensitive potassium channels.
    Stroke, 1999, Volume: 30, Issue:9

    Topics: Adenosine Triphosphate; Animals; Cerebrovascular Circulation; Glyburide; Hemodilution; Hypoxia; Male

1999
Enhanced beta-receptor-mediated vasorelaxation in hypoxic porcine coronary artery.
    The American journal of physiology, 1999, Volume: 277, Issue:4

    Topics: Animals; Arteries; Coronary Vessels; Cyclic AMP; Endothelin-1; Glyburide; Hypoxia; In Vitro Techniqu

1999
Role of an ATP-sensitive potassium channel opener, YM934, in mitochondrial energy production in ischemic/reperfused heart.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 291, Issue:2

    Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Benzoxazines; Creatine Kinase; Cyclic N-Oxi

1999
Adaptation to high altitude hypoxia protects the rat heart against ischemia-induced arrhythmias. Involvement of mitochondrial K(ATP) channel.
    Journal of molecular and cellular cardiology, 1999, Volume: 31, Issue:10

    Topics: Acclimatization; Altitude; Animals; Arrhythmias, Cardiac; Glyburide; Heart; Heart Rate; Heart Ventri

1999
Mechanism of hypoxic pulmonary vasoconstriction involves ET(A) receptor-mediated inhibition of K(ATP) channel.
    American journal of physiology. Lung cellular and molecular physiology, 2000, Volume: 278, Issue:3

    Topics: Adenosine Triphosphate; Animals; Blood; Endothelin Receptor Antagonists; Glyburide; Hypoxia; In Vitr

2000
Activation of sulphonylurea-sensitive channels and the NO-cGMP pathway decreases the heart rate response to sympathetic nerve stimulation.
    Cardiovascular research, 2000, Volume: 47, Issue:1

    Topics: Analysis of Variance; Animals; Cyclic GMP; Diazoxide; Electric Stimulation; Enzyme Inhibitors; Glybu

2000
Voltage-gated potassium channels in human ductus arteriosus.
    Lancet (London, England), 2000, Jul-08, Volume: 356, Issue:9224

    Topics: 4-Aminopyridine; Charybdotoxin; Cyclooxygenase Inhibitors; Ductus Arteriosus; Ductus Arteriosus, Pat

2000
Analysis of single K(ATP) channels in mammalian dentate gyrus granule cells.
    Journal of neurophysiology, 2000, Volume: 84, Issue:5

    Topics: Animals; Antihypertensive Agents; Dentate Gyrus; Diazoxide; Glyburide; Hypoglycemia; Hypoglycemic Ag

2000
Increased mitochondrial K(ATP) channel activity during chronic myocardial hypoxia: is cardioprotection mediated by improved bioenergetics?
    Circulation research, 2000, Nov-10, Volume: 87, Issue:10

    Topics: Adaptation, Physiological; Adenosine Triphosphate; Animals; Animals, Newborn; Benzopyrans; Cell Hypo

2000
Nitric oxide activates the sarcolemmal K(ATP) channel in normoxic and chronically hypoxic hearts by a cyclic GMP-dependent mechanism.
    Journal of molecular and cellular cardiology, 2001, Volume: 33, Issue:2

    Topics: Action Potentials; Animals; Animals, Newborn; Blood Pressure; Cyclic GMP; Electron Spin Resonance Sp

2001
Effects of phosphodiesterase inhibitors on hypoxic pulmonary vasoconstriction. Influence of K(+) channels and nitric oxide.
    European journal of pharmacology, 2001, Apr-06, Volume: 417, Issue:1-2

    Topics: 4-Aminopyridine; Animals; Apamin; Charybdotoxin; Dose-Response Relationship, Drug; Enzyme Inhibitors

2001
Intrinsic optical signals in respiratory brain stem regions of mice: neurotransmitters, neuromodulators, and metabolic stress.
    Journal of neurophysiology, 2001, Volume: 86, Issue:1

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Adenosine; Adenosine Triphosphate; Animals; Animals, Newborn;

2001
Hemodynamic effects of levcromakalim in neonatal porcine pulmonary hypertension.
    Biology of the neonate, 2001, Volume: 80, Issue:1

    Topics: Animals; Animals, Newborn; Blood Pressure; Cromakalim; Disease Models, Animal; Glyburide; Hemodynami

2001
Activation of ATP-sensitive potassium channels in hypoxic cardiac failure is not mediated by adenosine-1 receptors in the isolated rat heart.
    Journal of cardiovascular pharmacology and therapeutics, 2001, Volume: 6, Issue:2

    Topics: Action Potentials; Animals; Blood Pressure; Female; Glyburide; Heart Rate; Hypoglycemic Agents; Hypo

2001
Reduction of Ca(2+) channel activity by hypoxia in human and porcine coronary myocytes.
    Cardiovascular research, 2002, Volume: 53, Issue:1

    Topics: Animals; Calcium; Calcium Channels, L-Type; Coronary Vessels; Cytosol; Fluorometry; Glyburide; Human

2002
Analysis of the effects of graded levels of hypoxia on noradrenaline-evoked contraction in the rat iliac artery in vitro.
    Experimental physiology, 2002, Volume: 87, Issue:2

    Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Calcium; Calcium Channel Blockers; Calcium

2002
Role of myocardium and endothelium in coronary vascular smooth muscle responses to hypoxia.
    American journal of physiology. Heart and circulatory physiology, 2002, Volume: 282, Issue:4

    Topics: Acetylcholine; Animals; Arachidonic Acid; Coronary Vessels; Endothelium, Vascular; Glyburide; Heart;

2002
Exercise training alters an anoxia-induced, glibenclamide-sensitive current in rat ventricular cardiocytes.
    Journal of applied physiology (Bethesda, Md. : 1985), 2002, Volume: 92, Issue:4

    Topics: Adenosine Triphosphate; Animals; Female; Glyburide; Heart Ventricles; Hypoglycemic Agents; Hypoxia;

2002
Mitochondrial ATP-sensitive K+ channels influence force development and anoxic contractility in a flatfish, yellowtail flounder Limanda ferruginea, but not Atlantic cod Gadus morhua heart.
    The Journal of experimental biology, 2002, Volume: 205, Issue:Pt 10

    Topics: Aerobiosis; Animals; ATP-Binding Cassette Transporters; Decanoic Acids; Diazoxide; Fishes; Flounder;

2002
Opposing actions of tolbutamide and glibenclamide on hypoxic pulmonary vasoconstriction.
    Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 1992, Volume: 102, Issue:3

    Topics: Animals; Benzopyrans; Cromakalim; Diazoxide; Glyburide; Hypoxia; In Vitro Techniques; Lung; Male; Po

1992
Influence of ATP-sensitive potassium channel blocker on hypoxia-induced damage of isolated guinea pig heart.
    General pharmacology, 1992, Volume: 23, Issue:5

    Topics: Adenosine Triphosphate; Animals; Glyburide; Guinea Pigs; Heart Rate; Hypoxia; L-Lactate Dehydrogenas

1992
Anoxia induces time-independent K+ current through KATP channels in isolated heart cells of the guinea-pig.
    The Journal of physiology, 1992, Volume: 454

    Topics: Action Potentials; Adenosine Triphosphate; Animals; Glyburide; Guinea Pigs; Heart; Heart Ventricles;

1992
Evidence that epithelium-dependent relaxation of vascular smooth muscle detected by co-axial bioassays is not attributable to hypoxia.
    British journal of pharmacology, 1992, Volume: 105, Issue:4

    Topics: Animals; Aorta; Benzopyrans; Biological Assay; Biological Factors; Cromakalim; Epithelium; Glyburide

1992
Hypoxia-evoked dilatation of rabbit isolated basilar arteries is not mediated by the opening of glibenclamide-sensitive potassium channels.
    Japanese journal of pharmacology, 1992, Volume: 58 Suppl 2

    Topics: Animals; Basilar Artery; Benzopyrans; Cromakalim; Glyburide; Hypoxia; In Vitro Techniques; Male; Pot

1992
Effects of glibenclamide and tolbutamide on ischemia- and ouabain-induced arrhythmias and membrane potentials of ventricular myocardium from rat and guinea pig.
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1991, Volume: 12, Issue:5

    Topics: Animals; Arrhythmias, Cardiac; Dose-Response Relationship, Drug; Female; Glyburide; Guinea Pigs; Hyp

1991
Effects of inhibitors of EDRF and EDHF on vasoreactivity of perfused rat lungs.
    The American journal of physiology, 1991, Volume: 260, Issue:2 Pt 1

    Topics: Analysis of Variance; Angiotensin II; Animals; Biological Factors; Blood Pressure; Glyburide; Hemogl

1991
K+ channels and metabolic inhibition in cardiac cells.
    Bratislavske lekarske listy, 1991, Volume: 92, Issue:1

    Topics: Adenosine Triphosphate; Animals; Glyburide; Hypoxia; Myocardium; Potassium Channels; Sodium

1991
ATP-dependent K+ channels modulate vasoconstrictor responses to severe hypoxia in isolated ferret lungs.
    The Journal of clinical investigation, 1991, Volume: 88, Issue:2

    Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Ferrets; Glucose; Glyburide; Hypoxia; In V

1991
Effects of ATP-sensitive K+ channel blockers on the action potential shortening in hypoxic and ischaemic myocardium.
    British journal of pharmacology, 1991, Volume: 103, Issue:1

    Topics: Action Potentials; Adenosine Triphosphate; Animals; Coronary Circulation; Coronary Disease; Dogs; Fe

1991
Activation of cardiac ATP-sensitive K+ current during hypoxia: correlation with tissue ATP levels.
    The American journal of physiology, 1991, Volume: 261, Issue:3 Pt 2

    Topics: Action Potentials; Adenine Nucleotides; Adenosine Triphosphate; Anaerobiosis; Animals; Glyburide; Hy

1991
Effect of anoxia on intracellular and extracellular potassium activity in hypoglossal neurons in vitro.
    Journal of neurophysiology, 1991, Volume: 66, Issue:1

    Topics: Animals; Cells, Cultured; Electrophysiology; Extracellular Space; Glyburide; Hypoglossal Nerve; Hypo

1991
Hypoxic dilation of coronary arteries is mediated by ATP-sensitive potassium channels.
    Science (New York, N.Y.), 1990, Mar-16, Volume: 247, Issue:4948

    Topics: Adenosine Triphosphate; Animals; Antihypertensive Agents; Benzopyrans; Bradykinin; Coronary Vessels;

1990
Contrasting effects of hypoxia on tension in rat pulmonary and mesenteric arteries.
    The American journal of physiology, 1990, Volume: 259, Issue:2 Pt 2

    Topics: Animals; Benzopyrans; Cromakalim; Endothelium, Vascular; Glyburide; Hypoxia; In Vitro Techniques; Ma

1990
Potassium accumulation in the globally ischemic mammalian heart. A role for the ATP-sensitive potassium channel.
    Circulation research, 1990, Volume: 67, Issue:4

    Topics: Action Potentials; Adenosine Triphosphate; Animals; Coronary Disease; Dinitrophenols; Electric Condu

1990
Adenosine triphosphate-sensitive potassium channels in anoxia.
    Stroke, 1990, Volume: 21, Issue:11 Suppl

    Topics: Adenosine Triphosphate; Animals; Diazoxide; Electrophysiology; Glyburide; Hippocampus; Hypoxia; Neur

1990
Inhibitor of ATP-sensitive K+ channel alters neither hypoxic contraction nor relaxation of rat aorta.
    Blood vessels, 1990, Volume: 27, Issue:6

    Topics: Adenosine Triphosphate; Animals; Aorta; Glyburide; Hypoxia; Potassium Channels; Rats; Vasoconstricti

1990
BRL 34915 (cromakalim) activates ATP-sensitive K+ current in cardiac muscle.
    Proceedings of the National Academy of Sciences of the United States of America, 1988, Volume: 85, Issue:21

    Topics: Action Potentials; Adenosine Triphosphate; Animals; Antihypertensive Agents; Benzopyrans; Cromakalim

1988
Effect of glibenclamide, a selective blocker of an ATP-K+ channel, on the anoxic response of hippocampal neurones.
    Pflugers Archiv : European journal of physiology, 1989, Volume: 414 Suppl 1

    Topics: Adenosine Triphosphate; Animals; Glyburide; Hippocampus; Hypoxia; In Vitro Techniques; Male; Neurons

1989