glyburide has been researched along with Alzheimer Disease in 9 studies
Glyburide: An antidiabetic sulfonylurea derivative with actions like those of chlorpropamide
glyburide : An N-sulfonylurea that is acetohexamide in which the acetyl group is replaced by a 2-(5-chloro-2-methoxybenzamido)ethyl group.
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Given the renal tubular transport and extensive urinary excretion of memantine and metformin, it was of interest to assess the pharmacokinetic and pharmacodynamic interaction with glyburide/metformin." | 2.71 | Investigation of the pharmacokinetic and pharmacodynamic interactions between memantine and glyburide/metformin in healthy young subjects: a single-center, multiple-dose, open-label study. ( Abramowitz, W; Chou, T; Rao, N; Ventura, D, 2005) |
| "Alzheimer's disease is the most common cause of dementia in the elderly population." | 1.72 | Effects of antidiabetic agents on Alzheimer's disease biomarkers in experimentally induced hyperglycemic rat model by streptozocin. ( Ali, RH; Ali, SK, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 2 (22.22) | 24.3611 |
| 2020's | 4 (44.44) | 2.80 |
| Authors | Studies |
|---|---|
| Ali, SK | 1 |
| Ali, RH | 1 |
| Esmaeili, MH | 2 |
| Enayati, M | 1 |
| Khabbaz Abkenar, F | 1 |
| Ebrahimian, F | 1 |
| Salari, AA | 2 |
| Zubov, A | 1 |
| Muruzheva, Z | 1 |
| Tikhomirova, M | 1 |
| Karpenko, M | 1 |
| Ju, YJ | 1 |
| Kim, N | 1 |
| Gee, MS | 1 |
| Jeon, SH | 1 |
| Lee, D | 1 |
| Do, J | 1 |
| Ryu, JS | 1 |
| Lee, JK | 1 |
| Bahari, B | 1 |
| Baraka, A | 1 |
| ElGhotny, S | 1 |
| Rao, N | 1 |
| Chou, T | 1 |
| Ventura, D | 1 |
| Abramowitz, W | 1 |
| Ikeda, M | 1 |
| Dewar, D | 1 |
| McCulloch, J | 1 |
| Hoyer, S | 1 |
| Lee, SK | 1 |
| Löffler, T | 1 |
| Schliebs, R | 1 |
1 review available for glyburide and Alzheimer Disease
| Article | Year |
|---|---|
Glibenclamide as a neuroprotective antidementia drug.
Topics: Alzheimer Disease; Diabetes Mellitus; Glyburide; Humans; Hypoglycemic Agents; Neuroprotective Agents | 2022 |
1 trial available for glyburide and Alzheimer Disease
| Article | Year |
|---|---|
Investigation of the pharmacokinetic and pharmacodynamic interactions between memantine and glyburide/metformin in healthy young subjects: a single-center, multiple-dose, open-label study.
Topics: Adult; Alzheimer Disease; Diabetes Mellitus, Type 2; Drug Combinations; Drug Interactions; Female; G | 2005 |
7 other studies available for glyburide and Alzheimer Disease
| Article | Year |
|---|---|
Effects of antidiabetic agents on Alzheimer's disease biomarkers in experimentally induced hyperglycemic rat model by streptozocin.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases | 2022 |
Glibenclamide mitigates cognitive impairment and hippocampal neuroinflammation in rats with type 2 diabetes and sporadic Alzheimer-like disease.
Topics: Alzheimer Disease; Animals; Cognitive Dysfunction; Diabetes Complications; Diabetes Mellitus, Type 2 | 2020 |
Glibenclamide modulates microglial function and attenuates Aβ deposition in 5XFAD mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Anti-Inflammatory | 2020 |
ATP-sensitive potassium-channel inhibitor glibenclamide attenuates HPA axis hyperactivity, depression- and anxiety-related symptoms in a rat model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Anxiety; Corticosterone; Depression; Disease Mode | 2018 |
Study of the effect of inhibiting galanin in Alzheimer's disease induced in rats.
Topics: Administration, Oral; Alzheimer Disease; Amyloid beta-Peptides; Animals; Avoidance Learning; Brain; | 2010 |
High affinity hippocampal [3H]-glibenclamide binding sites are preserved in Alzheimer's disease.
Topics: Adenosine Triphosphate; Aged; Aged, 80 and over; Alzheimer Disease; Autoradiography; Binding Sites; | 1993 |
Inhibition of the neuronal insulin receptor. An in vivo model for sporadic Alzheimer disease?
Topics: Alzheimer Disease; Animals; ATP-Binding Cassette Transporters; Autoradiography; Brain; Cerebral Vent | 2000 |