glyburide has been researched along with Alloxan Diabetes in 425 studies
Glyburide: An antidiabetic sulfonylurea derivative with actions like those of chlorpropamide
glyburide : An N-sulfonylurea that is acetohexamide in which the acetyl group is replaced by a 2-(5-chloro-2-methoxybenzamido)ethyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "As a serotonin antagonist, tropisetron positively affects blood glucose lowering, insulin synthesis, pancreas inflammation, and apoptosis in diabetes." | 8.31 | Tropisetron improved testicular inflammation in the streptozotocin-induced diabetic rats: The role of toll-like receptor 4 (TLR4) and mir146a. ( Moslehi, A; Naderi, R; Pourheydar, B, 2023) |
| " Fasiglifam/TAK-875, a selective GPR40 agonist, enhances glucose-stimulated insulin secretion and improves hyperglycemia." | 7.83 | Fasiglifam/TAK-875, a Selective GPR40 Agonist, Improves Hyperglycemia in Rats Unresponsive to Sulfonylureas and Acts Additively with Sulfonylureas. ( Ito, R; Matsuda, K; Miyawaki, K; Suzuki, M; Takeuchi, K; Tsujihata, Y, 2016) |
| "To investigate the dynamics of the intracellular Ca2+ concentration ([Ca2+]i) during retinal ischemia in rats with streptozotocin (STZ)-induced diabetes and the effect of gliclazide, a sulfonylurea with a potent free-radical scavenging activity on ischemia-induced [Ca2+]i dynamics." | 7.73 | Gliclazide attenuates the intracellular Ca2+ changes induced in vitro by ischemia in the retinal slices of rats with streptozotocin-induced diabetes. ( Harata, N; Kinukawa, J; Shimura, M; Tamai, M, 2005) |
| "The prevalence of nonalcoholic fatty liver disease (NAFLD) is much higher in patients with type II diabetes (T2D)." | 5.91 | Dimethyl fumarate-mediated Nrf2/ARE pathway activation and glibenclamide-mediated NLRP3 inflammasome cascade inhibition alleviate type II diabetes-associated fatty liver in rats by mitigating oxidative stress and inflammation. ( Dwivedi, DK; Jena, GB, 2023) |
| "As a serotonin antagonist, tropisetron positively affects blood glucose lowering, insulin synthesis, pancreas inflammation, and apoptosis in diabetes." | 4.31 | Tropisetron improved testicular inflammation in the streptozotocin-induced diabetic rats: The role of toll-like receptor 4 (TLR4) and mir146a. ( Moslehi, A; Naderi, R; Pourheydar, B, 2023) |
| " Group I acted as the control, whereas groups II, III, IV, and V were considered experimental groups which received a single dosage (150 mg/kg body weight) of alloxan (ALX) intraperitoneally (i." | 4.12 | Co-administration of ( Kar, A; Panda, S; Sharma, N; Yadav, D, 2022) |
| " Outcomes of normoglycemic studies reveals insignificant glucose lowering effects however hyperglycemic studies (glucose challenge and Alloxan inducted hyperglycemia) demonstrates significant glucose lowering effect of Aseel date especially with 300mg/kg dose." | 3.85 | Report - Antidiabetic effects of native date fruit Aseel (Phoenix dactylifera L.) in normal and hyperglycemic rats. ( Afroz, S; Ahmed, S; Jamil, S; Khan, RA, 2017) |
| " Fasiglifam/TAK-875, a selective GPR40 agonist, enhances glucose-stimulated insulin secretion and improves hyperglycemia." | 3.83 | Fasiglifam/TAK-875, a Selective GPR40 Agonist, Improves Hyperglycemia in Rats Unresponsive to Sulfonylureas and Acts Additively with Sulfonylureas. ( Ito, R; Matsuda, K; Miyawaki, K; Suzuki, M; Takeuchi, K; Tsujihata, Y, 2016) |
| "Dietary supplementation with CM fruits effectively prevents the development of diabetes mellitus, dyslipidemia and hepatic inflammation in alloxan-induced diabetes." | 3.80 | Biochemical and histopathological study of the anti-hyperglycemic and anti-hyperlipidemic effects of cornelian cherry (Cornus mas L.) in alloxan-induced diabetic rats. ( Asgary, S; Najafi, S; Rafieian-Kopaei, M; Sahebkar, A; Shamsi, F, 2014) |
| "To investigate the dynamics of the intracellular Ca2+ concentration ([Ca2+]i) during retinal ischemia in rats with streptozotocin (STZ)-induced diabetes and the effect of gliclazide, a sulfonylurea with a potent free-radical scavenging activity on ischemia-induced [Ca2+]i dynamics." | 3.73 | Gliclazide attenuates the intracellular Ca2+ changes induced in vitro by ischemia in the retinal slices of rats with streptozotocin-induced diabetes. ( Harata, N; Kinukawa, J; Shimura, M; Tamai, M, 2005) |
| " The body weight changes, blood and urine glucose level changes were monitored with changes on the pancreas weight, and after sacrifice, the histopathological changes of pancreas and the changes of insulin- and glucagon-producing cells were also observed by immunohistochemistry." | 3.73 | Anti-diabetic activity of SMK001, a poly herbal formula in streptozotocin induced diabetic rats: therapeutic study. ( Choi, HS; Choi, HY; Kang, SM; Kim, JD; Ku, SK; Seo, BI, 2006) |
| "Repaglinide is a novel insulin secretagogue being developed for the management of type 2 (non-insulin-dependent) diabetes mellitus." | 2.40 | Repaglinide. ( Balfour, JA; Faulds, D, 1998) |
| "Alloxan was used to induce diabetes in the rats in groups II to VI." | 1.91 | Carbohydrate digestive enzyme inhibition, hepatoprotective, antioxidant and antidiabetic benefits of Persea americana. ( Azeke, MA; Ehikioya, CO; Omage, K; Omage, SO; Osagie, AM, 2023) |
| " Nanoparticles (NP) of GB and organophilized Layered Double Hydroxide (LDH) were developed to improve oral bioavailability and tested in streptozotocin-induced diabetic rats to evaluate therapeutic efficacy and safety." | 1.91 | Efficacy and safety of nanoparticles of glibenclamide and organomodified layered double hydroxides in diabetics rats. ( Alvarez-Lorenzo, C; da Costa Silva Neto, J; Dal Santo, G; Damasceno Leão, A; Duarte Vieira, L; Fontana Agostini, J; Gonçalves da Silva, T; Gonçalves Wanderley, A; Lamartine Soares-Sobrinho, J; Ribeiro da Silva, J; Rodrigues de Lima Porto Ramos, K, 2023) |
| "The prevalence of nonalcoholic fatty liver disease (NAFLD) is much higher in patients with type II diabetes (T2D)." | 1.91 | Dimethyl fumarate-mediated Nrf2/ARE pathway activation and glibenclamide-mediated NLRP3 inflammasome cascade inhibition alleviate type II diabetes-associated fatty liver in rats by mitigating oxidative stress and inflammation. ( Dwivedi, DK; Jena, GB, 2023) |
| "Alzheimer's disease is the most common cause of dementia in the elderly population." | 1.72 | Effects of antidiabetic agents on Alzheimer's disease biomarkers in experimentally induced hyperglycemic rat model by streptozocin. ( Ali, RH; Ali, SK, 2022) |
| " Friedelan-3-one was shown to be non-carcinogenic, non-hepatotoxic, has decent oral bioavailability and a good compound for optimisation into a drug candidate." | 1.62 | Myrianthus libericus: Possible mechanisms of hypoglycaemic action and in silico prediction of pharmacokinetics and toxicity profile of its bioactive metabolite, friedelan-3-one. ( Adongo, DW; Amponsah, IK; Baah, MK; Ben, IO; Fleischer, TC; Harley, BK; Mensah, AY; Mireku-Gyimah, NA, 2021) |
| "Forty male Wistar rats were randomly divided in to eight equal groups including healthy and diabetic controls and six treated groups with a various doses of HESS alone and in combination with glibenclamide, for 35 consecutive days." | 1.56 | Effects of Securigera Securidaca seed extract in combination with glibenclamide on antioxidant capacity, fibroblast growth factor 21 and insulin resistance in hyperglycemic rats. ( Alizadeh-Fanalou, S; Azadi, N; Babaei, M; Bahreini, E; Borji, M; Hosseini, A; Malekinejad, H; Nazarizadeh, A; Shojaii, A, 2020) |
| "Establishment of NAFLD was clearly indicated by significant increase in liver weight, glucose, triglyceride, cholesterol, % glycosylated haemoglobin and insulin levels, and GLB intervention reduced the same." | 1.56 | NLRP3 inhibitor glibenclamide attenuates high-fat diet and streptozotocin-induced non-alcoholic fatty liver disease in rat: studies on oxidative stress, inflammation, DNA damage and insulin signalling pathway. ( Dwivedi, DK; Jena, GB, 2020) |
| "Alloxan treatment increased the levels of FBG, total cholesterol, LDL-cholesterol, VLDL-cholesterol, urine ketone and cardiac function indices and reduced the levels of globulin, albumin, HDL-cholesterol, globulin, liver glycogen, hexokinase and glucose-6-phosphate dehydrogenase activities." | 1.56 | Identification and characterization of anti-diabetic principle in Senna alata (Linn.) flower using alloxan-induced diabetic male Wistar rats. ( Ajiboye, TO; Ashafa, AOT; Uwazie, JN; Yakubu, MT, 2020) |
| " This study evaluates the anti-diabetic effect of cumin and glyburide in the streptozotocin induced diabetes model in rats, and investigates their pharmacodynamic interactions and its implication in diabetes." | 1.51 | Pharmacodynamic interaction of cumin seeds (Cuminum cyminum L.) with glyburide in diabetes. ( Invally, M; Kaur, G; Tharappel, LJP; Upadhyay, N, 2019) |
| " humilis or 2-hydroxy-destigloyl-6-deoxyswietenine acetate (mexicanolide 1) with glibenclamide resulted in a reduction of the antihyperglycemic effect while a significant increase was observed when they were dosed with metformin." | 1.51 | Multi-target antidiabetic mechanisms of mexicanolides from Swietenia humilis. ( Haddad, PS; Mata, R; Navarrete, A; Noriega, LG; Ovalle-Magallanes, B; Tovar, AR; Tovar-Palacio, C, 2019) |
| "In an attempt to decrease the dose, anticipated side effects, and the cost of production of glibenclamide, GLC, a potent oral hypoglycemic drug, the enhancement of the dissolution and hence the oral bioavailability were investigated." | 1.48 | Glibenclamide Mini-tablets with an Enhanced Pharmacokinetic and Pharmacodynamic Performance. ( Abdellatif, AAH; El Hamd, MA; Roberts, M; Tawfeek, HM; Younis, MA, 2018) |
| "We compared the individual effects of mitiglinide and glibenclamide administered in combination with the dipeptidyl peptidase-IV (DPP-IV) inhibitor sitagliptin on plasma DPP-IV activity and blood glucose levels in rats with streptozotocin-nicotinamide-induced type 2 diabetes (STZ-NA rats)." | 1.46 | Comparison of the Effects of Mitiglinide and Glibenclamide Administered in Combination with the Dipeptidyl Peptidase-IV Inhibitor Sitagliptin in Rats with Streptozotocin-Nicotinamide-Induced Type 2 Diabetes. ( Akahane, K; Inoue, T; Kiguchi, S; Kobayashi, M; Ojima, K; Takeda, H; Tatemichi, S; Yokoyama, A, 2017) |
| "Diabetic encephalopathy is an important complication of diabetes characterized by cognitive impairment, neurochemical and structural abnormalities." | 1.46 | Coenzyme Q10 and niacin mitigate streptozotocin- induced diabetic encephalopathy in a rat model. ( Aboul Naser, AF; Darwish, HA; El-Rigal, NS; Hamed, MA; Motawi, TK, 2017) |
| "Treatment with indomethacin reduced IP response in the hyper-reactive model, and did not produce any change in diabetic model with hyper-reactive airways, indicating further disruption of the COX pathway." | 1.43 | Deterioration of epithelium mediated mechanisms in diabetic-antigen sensitized airways of guinea pigs. ( Bano, S; Kambadur, M; Mohammad, F; Swati, O, 2016) |
| "Chronic inflammation is known to occur in diabetes mellitus (DM) and contributes to atrial fibrosis, possible substrates for atrial fibrillation." | 1.43 | No Additional Effect of DPP-4 Inhibitor on Preventing Atrial Fibrosis in Streptozotocin-Induced Diabetic Rat as Compared With Sulfonylurea. ( Hayami, N; Iwasaki, YK; Murakawa, Y; Sekiguchi, A; Yamashita, T, 2016) |
| " The aim of this work was to evaluate antidiabetic activity in Streptozotocin (STZ)-induced diabetic rats and the antioxidant effects of 3',4'-Di-O-acetyl-cis-khellactone (DOAcK), as well as its toxic potential." | 1.43 | Antidiabetic effect, antioxidant activity, and toxicity of 3',4'-Di-O-acetyl-cis-khellactone in Streptozotocin-induced diabetic rats. ( Burgueño-Tapia, E; Cornejo-Garrido, J; Domínguez-Mendoza, EA; Ordaz-Pichardo, C, 2016) |
| " The results revealed that BA and AD led to the PK/PD changes because of glyburide-increased bioavailability and because of the inhibition of CYP3A4 enzyme." | 1.43 | Pharmacokinetic and Pharmacodynamic Interaction of Boswellic Acids and Andrographolide with Glyburide in Diabetic Rats: Including Its PK/PD Modeling. ( Samala, S; Veeresham, C, 2016) |
| "Glibenclamide and thymoquinone plasma concentrations were analysed using a sensitive RP-HPLC method, and non-compartmental model pharmacokinetic parameters were calculated." | 1.42 | Effects of Thymoquinone on the Pharmacokinetics and Pharmacodynamics of Glibenclamide in a Rat Model. ( Ahmad, A; Al-Jenoobi, FI; Al-Mohizea, AM; Alkharfy, KM; Khan, RM; Raish, M, 2015) |
| " reticulata extract did not cause mortality or produce any remarkable haematological, biochemical and histopathological adverse effects in rats." | 1.42 | Antioxidant, α-glucosidase inhibitory activity and sub-chronic toxicity of Derris reticulata extract: its antidiabetic potential. ( Chudapongse, N; Kumkrai, P; Weeranantanapan, O, 2015) |
| "Our study results showed that oral administration of swertiamarin at a dosage of 15, 25, 50 mg/kg bw for 28 days resulted in a significant (p < 0." | 1.42 | Immunohistochemistry, histopathology, and biomarker studies of swertiamarin, a secoiridoid glycoside, prevents and protects streptozotocin-induced β-cell damage in Wistar rat pancreas. ( Dhanavathy, G, 2015) |
| "Kaempferol is a flavonoid found in many edible plants (e." | 1.42 | Influence of kaempferol, a flavonoid compound, on membrane-bound ATPases in streptozotocin-induced diabetic rats. ( Al-Numair, KS; Alsaif, MA; Chandramohan, G; Veeramani, C, 2015) |
| "Hyperlipidemia is an associated complication of diabetes and also a major risk factor for cardiovascular diseases." | 1.40 | Antidiabetic and antihyperlipidemic activity of asiatic acid in diabetic rats, role of HMG CoA: in vivo and in silico approaches. ( Ramachandran, V; Saravanan, R; Senthilraja, P, 2014) |
| "Sepsis is a common disease that continues to increase in incidence in the world." | 1.40 | Glibenclamide attenuates myocardial injury by lipopolysaccharides in streptozotocin-induced diabetic mice. ( Cai, J; Deng, YP; Jiang, GJ; Lu, S; Ren, GF; Shen, FM; Yao, Z; Yu, JW; Zhang, LD, 2014) |
| "Diabetic nephropathy is one of the important microvascular complications of diabetes; however, the main problem remains is the control of progression of nephropathy in diabetes." | 1.39 | Chebulic acid attenuates ischemia reperfusion induced biochemical alteration in diabetic rats. ( Gupta, VB; Silawat, N, 2013) |
| "Atorvastatin is a selective HMG-CoA reductase competitive inhibitor, used for the treatment of hyperlipidaemia." | 1.37 | Influence of atorvastatin on the pharmacokinetics and pharmacodynamics of glyburide in normal and diabetic rats. ( Gade, J; Neerati, P, 2011) |
| "05) reduced hyperglycemia, glibenclamide or metformin combined with honey produced significantly much lower blood glucose (8." | 1.37 | Glibenclamide or metformin combined with honey improves glycemic control in streptozotocin-induced diabetic rats. ( Erejuwa, OO; Gurtu, S; Salleh, MS; Sirajudeen, KN; Sulaiman, SA; Wahab, MS, 2011) |
| " Three groups of diabetic animals were orally administered daily with seed extract (SME) at a dosage of 50, 100 and 200 mg/kg BW." | 1.37 | Antioxidative and hypolipidemic efficacy of alcoholic seed extract of Swietenia macrophylla in streptozotocin diabetic rats. ( Kalpana, K; Pugalendi, KV, 2011) |
| " This study investigated the hypothesis that the common antidiabetic drugs glibenclamide and metformin, in combination with tualang honey, offer additional protection for the pancreas of streptozotocin (STZ)-induced diabetic rats against oxidative stress and damage." | 1.36 | Antioxidant protective effect of glibenclamide and metformin in combination with honey in pancreas of streptozotocin-induced diabetic rats. ( Erejuwa, OO; Gurtu, S; Salam, SK; Salleh, MS; Sulaiman, SA; Wahab, MS, 2010) |
| " Administration of ethanolic extract at a dosage of 0." | 1.36 | Antidiabetic and antihyperlipidemic activity of ethyl acetate:isopropanol (1:1) fraction of Vernonia anthelmintica seeds in streptozotocin induced diabetic rats. ( Babu, KR; Fatima, SS; Kumar, KV; Kumar, MT; Rajasekhar, MD; Rao, CA, 2010) |
| "Hyperlipidemia occurs in GDM." | 1.36 | Impact of hyperlipidemia on plasma protein binding and hepatic drug transporter and metabolic enzyme regulation in a rat model of gestational diabetes. ( Anger, GJ; Piquette-Miller, M, 2010) |
| " Subsequently, the effects of a 1-week chronic daily dosing of DPP-IV inhibitors and sulfonylureas were investigated." | 1.35 | Antidiabetic effects of dipeptidyl peptidase-IV inhibitors and sulfonylureas in streptozotocin-nicotinamide-induced mildly diabetic mice. ( Hayakawa, M; Matsuyama-Yokono, A; Nakano, R; Shibasaki, M; Shiraki, K; Someya, Y; Tahara, A, 2009) |
| "Adenosine is a potent vasodilator of retinal blood vessels and is implicated to be a major regulator of retinal blood flow during metabolic stress, but little is known about the impact of diabetes on the role of adenosine in regulation of retinal hemodynamics." | 1.35 | Vasodilator effects of adenosine on retinal arterioles in streptozotocin-induced diabetic rats. ( Ishii, K; Mori, A; Nakahara, T; Nakazawa, T; Saito, M; Sakamoto, K, 2008) |
| "The methanolic extract has also accelerated the process of spermatogenesis by increasing the sperm count and accessory sex organ weights." | 1.35 | Anti-diabetic, anti-hyperlipidemic and spermatogenic effects of Amaranthus spinosus Linn. on streptozotocin-induced diabetic rats. ( Jayakar, B; Sangameswaran, B, 2008) |
| " Meanwhile, in co-treated group, elimination rate constant (Ke) of glibenclamide was reduced while peak plasma concentration (C(max)), area under the plasma concentration vs time curve (AUC(0-14 h)) and elimination half-life (T(1/2Ke)) were increased significantly vs glibenclamide alone administered rats." | 1.35 | Effects of 18alpha-glycyrrhizin on the pharmacodynamics and pharmacokinetics of glibenclamide in alloxan-induced diabetic rats. ( Ao, Y; Chen, J; Peng, RX; Yue, J, 2008) |
| "More importantly, the incidence of ventricular tachycardia in the STZ-GLIB group was significantly higher than that in the STZ-VEH group (93% vs 54%, P < 0." | 1.32 | Long-term treatment with glibenclamide increases susceptibility of streptozotocin-induced diabetic rat heart to reperfusion-induced ventricular tachycardia. ( Iwao, T; Ooie, T; Saikawa, T; Sakata, T; Takahashi, N; Yoshimatsu, H, 2003) |
| "Gliclazide is a sulphonylurea antidiabetic drug with anti-oxidant effect due to its azabicyclo-octyl ring." | 1.32 | Radical scavenging effect of gliclazide in diabetic rats fed with a high cholesterol diet. ( Fujita, T; Goto, A; Onozato, ML; Tojo, A, 2004) |
| "Glyburide is a prescribed hypoglycemic drug for the treatment of type 2 diabetic patients." | 1.32 | Synthesis and evaluation of fluorine-18 labeled glyburide analogs as beta-cell imaging agents. ( Alavi, AA; Deng, S; Doliba, N; Feng, Q; Matschinsky, F; Naji, A; Pourdehnad, MT; Rösch, F; Schirrmacher, R; Schmitz, A; Shiue, CY; Shiue, GG; Vatamaniuk, M; Wolf, B, 2004) |
| " The patches were subjected to skin irritation test (by both visual observation and histopathological evaluation), oral glucose tolerance test and pharmacokinetic evaluation in mice." | 1.32 | Glibenclamide transdermal patches: physicochemical, pharmacodynamic, and pharmacokinetic evaluations. ( Mutalik, S; Udupa, N, 2004) |
| "Glyburide treatment of diabetic rats for 4 weeks corrected the changes observed in diabetic heart." | 1.32 | The effects of the sulfonylurea glyburide on glutathione peroxidase, superoxide dismutase and catalase activities in the heart tissue of streptozotocin-induced diabetic rat. ( Altan, N; Bilgihan, A; Buğdayci, G; Bukan, N; Kosova, F; Sancak, B, 2004) |
| "Diabetes, when uncontrolled, causes dyslipidemia often followed by atherogenic abnormalities." | 1.32 | Protective effects of ferulic acid on hyperlipidemic diabetic rats. ( Menon, VP; Rukkumani, R; Sri Balasubashini, M, 2003) |
| "Cromakalim treatment also prevented alloxan-induced hypercholesterolemia and hypertriglyceridaemia." | 1.31 | Effects of chronic treatment with cromakalim and glibenclamide in alloxan-induced diabetic rats. ( Goyal, RK; Kulkarni, JS; Metha, AA; Santani, DD, 2002) |
| "pinacidil was significantly antagonized by i." | 1.31 | Effect of diabetes on pinacidil-induced antinociception in mice. ( Kamei, J; Onodera, K; Zushida, K, 2002) |
| "IDDM was induced in rats by streptozotocin (STZ) injection, and adequate insulin was provided to maintain moderate hyperglycemia." | 1.31 | Exaggerated impact of ATP-sensitive K(+) channels on afferent arteriolar diameter in diabetes mellitus. ( Bast, JP; Carmines, PK; Fallet, RW; Ikenaga, H, 2000) |
| " The aqueous extract of Syzygium alternifolium at a dosage of 0." | 1.31 | Hypoglycemic and antihyperglycemic activity of Syzygium alternifolium (Wt.) Walp. seed extracts in normal and diabetic rats. ( Rao, BK; Rao, CH, 2001) |
| " The dose-response curve of insulin secretion showed a markedly reduced maximum response, but almost normal glucose sensitivity in NSY islets." | 1.31 | Insulin secretion to glucose as well as nonglucose stimuli is impaired in spontaneously diabetic Nagoya-Shibata-Yasuda mice. ( Babaya, N; Hamada, Y; Ikegami, H; Kawaguchi, Y; Nojima, K; Ogihara, T; Shibata, M; Ueda, H; Yamada, K; Yamato, E, 2001) |
| "A Leucodelphinidin derivative isolated from the bark of Ficus bengalensis Linn demonstrated hypoglycemic action at a dosage of 250 mg/kg given both in normal and alloxan diabetic rats." | 1.29 | Hypoglycemic effects of leucodelphinidin derivative isolated from Ficus bengalensis (Linn). ( Augusti, KT; Geetha, BS; Mathew, BC, 1994) |
| "3." | 1.29 | Effect of the sulfonylurea glyburide on glutathione and glutathione peroxidase activity in alloxan-induced diabetic rat hepatocytes. ( Altan, N; Cayci, B; Elmali, E; Kiliç, N; Ongun, CO; Yavuz, O, 1994) |
| "3." | 1.29 | The effects of glyburide and insulin on the decreased beta-adrenergic responsiveness of the gastrointestinal tract in rats with non-insulin-dependent diabetes. ( Altan, VM; Oztürk, Y; Ozüari, A; Yildizoğlu-Ari, N, 1994) |
| "Propranolol was found to exhibit a hypolipidemic effect in diabetic rats when administered alone or in combination with glibenclamide." | 1.29 | Studies on the glycemic and lipidemic effect of atenolol and propranolol in normal and diabetic rats. ( el Batran, S; Gaafar, K; Salama, S, 1994) |
| "Glyburide treatment of diabetic rats for 4 weeks corrected the changes observed in diabetic liver." | 1.29 | Effect of the sulfonylurea glyburide on superoxide dismutase activity in alloxan-induced diabetic rat hepatocytes. ( Altan, N; Engin, A; Hasanoğlu, E; Ongun, CO; Sindel, S; Tuncer, C, 1994) |
| "6." | 1.29 | The effects of glyburide and insulin on the cardiac performance in rats with non-insulin-dependent diabetes mellitus. ( Altan, VM; Ozçelkay, AT; Oztürk, Y; Ozüari, A; Yildizoğlu-Ari, N, 1993) |
| "Glimepiride is a new sulfonylurea." | 1.29 | Cardiovascular effects of conventional sulfonylureas and glimepiride. ( Geisen, K; Krause, E; Papp, JG; Végh, A, 1996) |
| " Dose-response curves revealed that 1 microgram/ml of glibenclamide (in the presence of 3." | 1.27 | Modulation by IBMX, fasting and experimental diabetes of glibenclamide-induced islet hormone release from the perfused rat pancreas. ( Efendić, S; Grill, V; Nylén, A; Ostenson, CG, 1983) |
| "When treated with glyburide, the severity of the mechanical defect was significantly less." | 1.27 | Effect of chronic sulfonylurea treatment on the myocardium of insulin-dependent diabetic rats. ( Mozaffari, MS; Schaffer, SW; Wilson, GL, 1988) |
| " Both extracts exert a significant hypoglycaemic effect by oral route and chronic administration in diabetic rats, but only the extract obtained by exhaustion with hot water displayed an acute hypoglycaemic activity in normal animals." | 1.26 | [Hypoglycaemic activity of centaurea aspera L (author's transl)]. ( Adzet, T; Massó, JL, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 33 (7.76) | 18.7374 |
| 1990's | 56 (13.18) | 18.2507 |
| 2000's | 128 (30.12) | 29.6817 |
| 2010's | 163 (38.35) | 24.3611 |
| 2020's | 45 (10.59) | 2.80 |
| Authors | Studies |
|---|---|
| Schweizer, EH | 1 |
| Märki, F | 1 |
| Lehmann, C | 1 |
| Dietrich, H | 1 |
| Nakashima, N | 1 |
| Kimura, I | 2 |
| Kimura, M | 2 |
| Matsuura, H | 1 |
| Nojima, H | 1 |
| Chen, FJ | 1 |
| Sugihara, Y | 1 |
| Haruno, M | 1 |
| Kato, A | 1 |
| Asano, N | 1 |
| Kumar, A | 6 |
| Pathak, SR | 1 |
| Ahmad, P | 4 |
| Ray, S | 1 |
| Tewari, P | 1 |
| Srivastava, AK | 7 |
| Shukla, P | 1 |
| Singh, AB | 4 |
| Pratap, R | 1 |
| Dwivedi, AP | 1 |
| Kumar, S | 1 |
| Varshney, V | 1 |
| Sahu, DP | 1 |
| Maurya, RA | 3 |
| Cristians, S | 1 |
| Guerrero-Analco, JA | 1 |
| Pérez-Vásquez, A | 1 |
| Palacios-Espinosa, F | 1 |
| Ciangherotti, C | 1 |
| Bye, R | 2 |
| Mata, R | 4 |
| Navarrete-Vazquez, G | 6 |
| Paoli, P | 2 |
| León-Rivera, I | 3 |
| Villalobos-Molina, R | 3 |
| Medina-Franco, JL | 5 |
| Ortiz-Andrade, R | 3 |
| Estrada-Soto, S | 9 |
| Camici, G | 2 |
| Diaz-Coutiño, D | 1 |
| Gallardo-Ortiz, I | 1 |
| Martinez-Mayorga, K | 1 |
| Moreno-Díaz, H | 1 |
| Sharma, S | 4 |
| Tamrakar, AK | 3 |
| Shingalapur, RV | 1 |
| Hosamani, KM | 1 |
| Keri, RS | 1 |
| Hugar, MH | 1 |
| Torres-Piedra, M | 1 |
| Singh, N | 1 |
| Webster, SP | 3 |
| Binnie, M | 2 |
| Tripathi, VD | 1 |
| Srivastava, SP | 2 |
| Bhatia, G | 1 |
| Brindis, F | 1 |
| Rodríguez, R | 1 |
| González-Andrade, M | 1 |
| Ramírez-Espinosa, JJ | 5 |
| Rios, MY | 1 |
| López-Martínez, S | 1 |
| López-Vallejo, F | 2 |
| Lam, SH | 1 |
| Ruan, CT | 1 |
| Hsieh, PH | 1 |
| Su, MJ | 1 |
| Lee, SS | 1 |
| Gupta, LP | 1 |
| Rahuja, N | 1 |
| Liu, H | 1 |
| Liu, L | 1 |
| Li, J | 1 |
| Mei, D | 1 |
| Duan, R | 1 |
| Hu, N | 1 |
| Guo, H | 1 |
| Zhong, Z | 1 |
| Liu, X | 2 |
| Yelovitch, S | 1 |
| Barr, HM | 1 |
| Camden, J | 1 |
| Weisman, GA | 1 |
| Shai, E | 1 |
| Varon, D | 1 |
| Fischer, B | 1 |
| Iqbal, Z | 1 |
| Ali, S | 1 |
| Iqbal, J | 1 |
| Abbas, Q | 1 |
| Qureshi, IZ | 1 |
| Hameed, S | 1 |
| Alaniz-Palacios, A | 1 |
| Hidalgo-Figueroa, S | 2 |
| González-Acevedo, C | 1 |
| Ávila-Villarreal, G | 1 |
| Guerrero-Álvarez, J | 1 |
| Tlahuext, H | 1 |
| Sirasanagandla, S | 1 |
| Kasetti, RB | 2 |
| Shaik, AN | 1 |
| Natava, R | 1 |
| Surtineni, VP | 1 |
| Cirradur, SR | 1 |
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| Horie, M | 1 |
| Imura, H | 1 |
| Seino, Y | 1 |
| Sato, Y | 1 |
| Nishikawa, M | 1 |
| Shinkai, H | 1 |
| Sukegawa, E | 1 |
| Boiadzhieva, N | 1 |
| Ajabnoor, MA | 1 |
| Kukuljan, M | 1 |
| Li, MY | 1 |
| Atwater, I | 1 |
| Jacobs, DB | 1 |
| Hayes, GR | 1 |
| Lockwood, DH | 1 |
| Mozaffari, MS | 2 |
| Allo, S | 1 |
| Schaffer, SW | 2 |
| Ikeda, T | 1 |
| Takeuchi, T | 1 |
| Ito, Y | 1 |
| Murakami, I | 1 |
| Mokuda, O | 1 |
| Tominaga, M | 1 |
| Mashiba, H | 1 |
| Chen, QM | 1 |
| Solomon, SS | 1 |
| Deaton, J | 1 |
| Shankar, TP | 1 |
| Palazzolo, M | 1 |
| Ghannam, N | 1 |
| Kingston, M | 1 |
| Al-Meshaal, IA | 1 |
| Tariq, M | 1 |
| Parman, NS | 1 |
| Woodhouse, N | 1 |
| Cook, GA | 1 |
| Gutniak, M | 1 |
| Leahy, JL | 1 |
| Samols, MD | 1 |
| Weir, GC | 1 |
| Wilson, GL | 1 |
| Foy, JM | 3 |
| Standing, VF | 3 |
| Lundquist, I | 1 |
| Ekholm, R | 1 |
| Ericson, LE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Pilot, Open-label Study to Evaluate the Effects of a Prostate Health Formulation on Scores Attained From the International Prostate Symptom Score (I-PSS) Questionnaire Among Overall Healthy Male Participants Who Report Lower Urinary Tract Complaints[NCT02886832] | 30 participants (Anticipated) | Interventional | 2016-09-21 | Completed | |||
| Effect of Mulberry Leaf Extract on Glycemic Durability in Non-insulin Dependent Diabetes Mellitus: a Double-blind, Randomized, Placebo-controlled Pilot Study (Mul-DM)[NCT00795704] | Phase 2/Phase 3 | 24 participants (Actual) | Interventional | 2008-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2-hour postprandial SMBG reported. A negative value indicates a decrease from baseline. A positive value indicates an increase from baseline. (NCT00795704)
Timeframe: Baseline and 3 months
| Intervention | mg/dL (Mean) |
|---|---|
| Placebo | -28.1 |
| Mulberry Leaf Extract | 3.6 |
(NCT00795704)
Timeframe: 3 month minus baseline
| Intervention | percent (Mean) |
|---|---|
| Placebo | -0.39 |
| Mulberry Leaf Extract | -0.26 |
Sodium (>150 mmol/L), Potassium (>5 mmol/L), Bicarbonate (>34 mmol/L), Chloride (>110 mmol/L), Serum Creatinine (>1.2 mg/dL), Blood Urea Nitrogen (24 mg/dL), Calcium (>11 mg/L), Alanine Aminotransferase (>3 times baseline), Aspartate Aminotransferase (>3 times baseline) were collected at baseline, 1 month, and 3 months. Self-Reported adverse drug reactions are also reported. (NCT00795704)
Timeframe: Baseline, 1 month, and 3 months
| Intervention | participants (Number) |
|---|---|
| Placebo | 6 |
| Mulberry Leaf Extract | 4 |
3 reviews available for glyburide and Alloxan Diabetes
| Article | Year |
|---|---|
Potassium channels in the cardiovascular system.
Topics: Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Cardiovascular Physiological Phenomena; Cardi | 1995 |
Stimulation of insulin release in vivo by the methyl esters of succinic acid and glutamic acid.
Topics: Animals; Diabetes Mellitus, Experimental; Glucose; Glutamic Acid; Glyburide; Insulin; Insulin Secret | 1997 |
Repaglinide.
Topics: Animals; Carbamates; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glyburide; Humans; | 1998 |
422 other studies available for glyburide and Alloxan Diabetes
| Article | Year |
|---|---|
Sulfonyliminoimidazolidines. A new class of oral hypoglycemic agents. 1. 1-[[p-[2-(acylamino)ethyl]phenyl]sulfonyl]-2-iminoimidazolidines.
Topics: Animals; Biological Assay; Blood Glucose; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Imid | 1983 |
Isolation of pseudoprototimosaponin AIII from rhizomes of Anemarrhena asphodeloides and its hypoglycemic activity in streptozotocin-induced diabetic mice.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Glyburide | 1993 |
Antihyperglycemic effects of N-containing sugars from Xanthocercis zambesiaca, Morus bombycis, Aglaonema treubii, and Castanospermum australe in streptozotocin-diabetic mice.
Topics: Animals; Blood Glucose; Carbohydrates; Diabetes Mellitus, Experimental; Dose-Response Relationship, | 1998 |
Novel substituted naphthalen-1-yl-methanone derivatives as anti-hyperglycemic agents.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Male; Naphthalenes; Ra | 2006 |
Chalcone based aryloxypropanolamines as potential antihyperglycemic agents.
Topics: Animals; Chalones; Diabetes Mellitus, Experimental; Hyperglycemia; Hypoglycemic Agents; Indicators a | 2007 |
Synthesis and antihyperglycemic activity of novel N-acyl-2-arylethylamines and N-acyl-3-coumarylamines.
Topics: Acylation; Animals; Blood Glucose; Coumaric Acids; Diabetes Mellitus, Experimental; Ethylamines; Hyp | 2008 |
Novel 2-aryl-naphtho[1,2-d]oxazole derivatives as potential PTP-1B inhibitors showing antihyperglycemic activities.
Topics: Animals; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Hypoglycemic Agents; Lipids; Mice; Oxaz | 2009 |
Hypoglycemic activity of extracts and compounds from the leaves of Hintonia standleyana and H. latiflora: potential alternatives to the use of the stem bark of these species.
Topics: Animals; Coumarins; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Mexico; Mice; Molecular St | 2009 |
Synthesis, in vitro and computational studies of protein tyrosine phosphatase 1B inhibition of a small library of 2-arylsulfonylaminobenzothiazoles with antihyperglycemic activity.
Topics: Animals; Benzothiazoles; Blood Glucose; Computer Simulation; Diabetes Mellitus, Experimental; Diabet | 2009 |
Design and synthesis of 3,5-diarylisoxazole derivatives as novel class of anti-hyperglycemic and lipid lowering agents.
Topics: Animals; Blood Glucose; Cholesterol; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dos | 2009 |
Derivatives of benzimidazole pharmacophore: synthesis, anticonvulsant, antidiabetic and DNA cleavage studies.
Topics: Animals; Anticonvulsants; Benzimidazoles; Diabetes Mellitus, Experimental; DNA Cleavage; DNA, Bacter | 2010 |
A comparative study of flavonoid analogues on streptozotocin-nicotinamide induced diabetic rats: quercetin as a potential antidiabetic agent acting via 11beta-hydroxysteroid dehydrogenase type 1 inhibition.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Animals; Blood Glucose; Computational Biology; Database | 2010 |
Design and synthesis of 2,4-disubstituted polyhydroquinolines as prospective antihyperglycemic and lipid modulating agents.
Topics: Animals; Diabetes Mellitus, Experimental; Drug Design; Dyslipidemias; Glycogen Phosphorylase; Hypogl | 2010 |
(Z)-3-butylidenephthalide from Ligusticum porteri , an α-glucosidase inhibitor.
Topics: Acarbose; Administration, Oral; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Me | 2011 |
Antidiabetic activity of some pentacyclic acid triterpenoids, role of PTP-1B: in vitro, in silico, and in vivo approaches.
Topics: Animals; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Drug Evaluation, Preclin | 2011 |
Hypoglycemic diterpenoids from Tinospora crispa.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diterpenes; Hypoglycemic Agents; Mice; Mole | 2012 |
Synthesis of propiophenone derivatives as new class of antidiabetic agents reducing body weight in db/db mice.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Eating; Hypoglycemic Agents; Hypolipidemic | 2012 |
Combined contributions of impaired hepatic CYP2C11 and intestinal breast cancer resistance protein activities and expression to increased oral glibenclamide exposure in rats with streptozotocin-induced diabetes mellitus.
Topics: Administration, Oral; Animals; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subf | 2012 |
Identification of a promising drug candidate for the treatment of type 2 diabetes based on a P2Y(1) receptor agonist.
Topics: Animals; Blood Glucose; Cell Line, Tumor; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2 | 2012 |
Dual action spirobicycloimidazolidine-2,4-diones: antidiabetic agents and inhibitors of aldose reductase-an enzyme involved in diabetic complications.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Diabetes Complications; Diabetes Mellitus; Diabetes Mell | 2013 |
Discovery, synthesis and in combo studies of a tetrazole analogue of clofibric acid as a potent hypoglycemic agent.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Animals; Binding Sites; Blood Glucose; Catalytic Domain | 2013 |
Antihyperglycemic and antihyperlipidemic activities of 2-(4-[(2-hydroxybenzyl) amino]-phenyl amino-methyl)-phenol in STZ induced diabetic rats.
Topics: Air; Aniline Compounds; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Drug S | 2013 |
Synthesis, hypoglycemic activity and molecular modeling studies of pyrazole-3-carbohydrazides designed by a CoMFA model.
Topics: Animals; Diabetes Mellitus, Experimental; Drug Design; Humans; Hydrazines; Hypoglycemic Agents; Male | 2013 |
Synthesis, in vitro and in silico studies of a PPARγ and GLUT-4 modulator with hypoglycemic effect.
Topics: Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; Glucose Transporter Type 4; Humans | 2014 |
Novel sulfonyl(thio)urea derivatives act efficiently both as insulin secretagogues and as insulinomimetic compounds.
Topics: Animals; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Insulin; Insulin Secretion; Male; Mol | 2014 |
Novel benzenesulfonylureas containing thiophenylpyrazoline moiety as potential antidiabetic and anticancer agents.
Topics: 3T3-L1 Cells; Animals; Antineoplastic Agents; Binding Sites; Catalytic Domain; Cell Line; Cell Proli | 2014 |
1,5-Diarylpyrazole and vanillin hybrids: Synthesis, biological activity and DFT studies.
Topics: Animals; Antioxidants; Benzaldehydes; Diabetes Mellitus, Experimental; Dose-Response Relationship, D | 2015 |
Antidiabetic effect of novel benzenesulfonylureas as PPAR-γ agonists and their anticancer effect.
Topics: Animals; Antineoplastic Agents; Cell Proliferation; Diabetes Mellitus, Experimental; Dose-Response R | 2015 |
Design, synthesis and Structure-activity relationship studies of new thiazole-based free fatty acid receptor 1 agonists for the treatment of type 2 diabetes.
Topics: Animals; Blood Glucose; CHO Cells; Cricetulus; Diabetes Mellitus, Experimental; Diabetes Mellitus, T | 2016 |
Synthesis and molecular docking of N'-arylidene-5-(4-chlorophenyl)-1-(3,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carbohydrazides as novel hypoglycemic and antioxidant dual agents.
Topics: Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Halogenation; Hydrazines; Hyp | 2016 |
Antidiabetic effect, antioxidant activity, and toxicity of 3',4'-Di-O-acetyl-cis-khellactone in Streptozotocin-induced diabetic rats.
Topics: Animals; Antioxidants; Blood Glucose; Body Weight; Catalase; Coumarins; Diabetes Mellitus, Experimen | 2016 |
Polypharmacology of N
Topics: Adenosine; Adenosine A3 Receptor Agonists; Adenosine A3 Receptor Antagonists; Adiponectin; Animals; | 2017 |
New insights into the biological activities of Chrysanthemum morifolium: Natural flavonoids alleviate diabetes by targeting α-glucosidase and the PTP-1B signaling pathway.
Topics: Animals; Cell Line, Tumor; Cholesterol; Chrysanthemum; Cricetulus; Diabetes Mellitus, Experimental; | 2019 |
Syzygium jambos extract mitigates pancreatic oxidative stress, inflammation and apoptosis and modulates hepatic IRS-2/AKT/GLUT4 signaling pathway in streptozotocin-induced diabetic rats.
Topics: Animals; Apoptosis; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Glucose Trans | 2021 |
Synergistic antidiabetic activity of Taraxacum officinale (L.) Weber ex F.H.Wigg and Momordica charantia L. polyherbal combination.
Topics: Animals; Blood Glucose; Cell Line; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Drug | 2022 |
Effect of Co-administration of Glibenclamide and Aqueous Calyx Extract of Hibiscus Sabdariffa on Oxidative Stress Markers in Streptozotocin-Induced Diabetic Rats.
Topics: Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Glyburide; Hibiscus; Male; Ox | 2021 |
Chitosan-Encapsulated Nano-selenium Targeting TCF7L2, PPARγ, and CAPN10 Genes in Diabetic Rats.
Topics: Animals; Antioxidants; Blood Glucose; Chitosan; Diabetes Mellitus, Experimental; Glyburide; Hypoglyc | 2023 |
Black Truffle Extract Exerts Antidiabetic Effects through Inhibition of Inflammation and Lipid Metabolism Regulation.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Ascomycota; Biological Products; Case-Contr | 2022 |
Effects of Combined
Topics: Animals; Aryldialkylphosphatase; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, | 2022 |
Hypoglycemic, hypolipidemic and hepatoprotective effects of
Topics: Alpinia; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glyburi | 2022 |
Effects of antidiabetic agents on Alzheimer's disease biomarkers in experimentally induced hyperglycemic rat model by streptozocin.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases | 2022 |
Ameliorative role of Cyanus depressus (M.Bieb.) Soják plant extract against diabetes-associated oxidative-stress-induced liver, kidney, and pancreas damage in rats.
Topics: Alanine Transaminase; Animals; Antioxidants; Apigenin; Aspartate Aminotransferases; Blood Glucose; C | 2022 |
Efficiency comparison of an isoeugenol-derivated compound, eugenosedin-A, with glibenclamide and pioglitazone in protecting cardiovascular dysfunction of diabetic SHR.
Topics: Animals; Diabetes Mellitus, Experimental; Glyburide; Hypoglycemic Agents; Pioglitazone; Rats; Rats, | 2023 |
Design, Synthesis, Molecular Modeling and Anti-Hyperglycemic Evaluation of Quinazoline-Sulfonylurea Hybrids as Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) and Sulfonylurea Receptor (SUR) Agonists.
Topics: Animals; Diabetes Mellitus, Experimental; Glyburide; Humans; Hypoglycemic Agents; Molecular Docking | 2022 |
Phytochemical Analysis and hypoglycemic potential of Filago hurdwarica (Wall. ex DC.) Wagenitz in alloxan induced diabetic mice.
Topics: Alkenes; Alloxan; Animals; Antioxidants; Asteraceae; Blood Glucose; Body Weight; Chloroform; Diabete | 2022 |
Investigation of the Chemical Composition, Antihyperglycemic and Antilipidemic Effects of
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diet, High-Fat; Glyburide; Hypoglycemic Age | 2022 |
Co-administration of
Topics: Alloxan; Animals; Antioxidants; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Glucose | 2022 |
Tropisetron improved testicular inflammation in the streptozotocin-induced diabetic rats: The role of toll-like receptor 4 (TLR4) and mir146a.
Topics: Animals; Diabetes Complications; Diabetes Mellitus, Experimental; Glyburide; Inflammation; Male; NF- | 2023 |
Tropisetron improved testicular inflammation in the streptozotocin-induced diabetic rats: The role of toll-like receptor 4 (TLR4) and mir146a.
Topics: Animals; Diabetes Complications; Diabetes Mellitus, Experimental; Glyburide; Inflammation; Male; NF- | 2023 |
Tropisetron improved testicular inflammation in the streptozotocin-induced diabetic rats: The role of toll-like receptor 4 (TLR4) and mir146a.
Topics: Animals; Diabetes Complications; Diabetes Mellitus, Experimental; Glyburide; Inflammation; Male; NF- | 2023 |
Tropisetron improved testicular inflammation in the streptozotocin-induced diabetic rats: The role of toll-like receptor 4 (TLR4) and mir146a.
Topics: Animals; Diabetes Complications; Diabetes Mellitus, Experimental; Glyburide; Inflammation; Male; NF- | 2023 |
Vulgarin, a Sesquiterpene Lactone from
Topics: Animals; Antioxidants; Artemisia; Blood Glucose; Diabetes Mellitus, Experimental; Glyburide; Hypogly | 2022 |
Carbohydrate digestive enzyme inhibition, hepatoprotective, antioxidant and antidiabetic benefits of Persea americana.
Topics: Alloxan; Animals; Antioxidants; Carbohydrates; Diabetes Mellitus, Experimental; Glyburide; Hypoglyce | 2023 |
Crude extract from
Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Euphorbia; Gliclazide; Glyburide; | 2023 |
Efficacy and safety of nanoparticles of glibenclamide and organomodified layered double hydroxides in diabetics rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glyburide; Hydro | 2023 |
Co-administration of metformin and/or glibenclamide with losartan reverse N
Topics: Animals; Antihypertensive Agents; Blood Pressure; Diabetes Mellitus, Experimental; Esters; Glyburide | 2023 |
Evaluation of acute oral toxicity, anti-diabetic and antioxidant effects of Aloe vera flowers extract.
Topics: Aloe; Animals; Antioxidants; Ascorbic Acid; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes | 2023 |
EXPERIMENTAL GESTATIONAL DIABETES DISRUPTS THE FORMATION OF IMMUNE TOLERANCE IN OFFSPRING.
Topics: Animals; CTLA-4 Antigen; Diabetes Mellitus, Experimental; Diabetes, Gestational; DNA-Binding Protein | 2023 |
Dimethyl fumarate-mediated Nrf2/ARE pathway activation and glibenclamide-mediated NLRP3 inflammasome cascade inhibition alleviate type II diabetes-associated fatty liver in rats by mitigating oxidative stress and inflammation.
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dimethyl Fumarate | 2023 |
Investigation of the effect of addition of Momordica charantia to glibenclamide on amelioration of endothelial dysfunction in diabetic rats by activating Takeda G protein-coupled receptor 5.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glyburide; Hypoglycemic Agents; Insulin; In | 2023 |
Pharmacological properties of Ensete glaucum seed extract: Novel insights for antidiabetic effects via modulation of oxidative stress, inflammation, apoptosis and MAPK signaling pathways.
Topics: alpha-Glucosidases; Animals; Apoptosis; bcl-2-Associated X Protein; Diabetes Mellitus, Experimental; | 2024 |
Effects of Securigera Securidaca seed extract in combination with glibenclamide on antioxidant capacity, fibroblast growth factor 21 and insulin resistance in hyperglycemic rats.
Topics: Animals; Antioxidants; Biomarkers; Blood Glucose; Diabetes Mellitus, Experimental; Drug Therapy, Com | 2020 |
The role of activation of K
Topics: Adenosine Triphosphate; Animals; Antioxidants; Apoptosis; Diabetes Mellitus, Experimental; Diabetic | 2020 |
NLRP3 inhibitor glibenclamide attenuates high-fat diet and streptozotocin-induced non-alcoholic fatty liver disease in rat: studies on oxidative stress, inflammation, DNA damage and insulin signalling pathway.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Diabetes Mellitus, Experimental; Diet, High-Fat; DN | 2020 |
Role of NLRP3-Inflammasome/Caspase-1/Galectin-3 Pathway on Atrial Remodeling in Diabetic Rabbits.
Topics: Alloxan; Animals; Anti-Inflammatory Agents; Atrial Fibrillation; Atrial Function, Left; Atrial Remod | 2020 |
Comparative effects of glibenclamide, metformin and insulin on fetal pancreatic histology and maternal blood glucose in pregnant streptozotocin-induced diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetes, Gestational; Female; | 2019 |
Glibenclamide nanosuspension inhaler: development,
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Drug Development; Glyburide; Hypoglycemic A | 2020 |
The beneficial effect of clove essential oil and its major component, eugenol, on erectile function in diabetic rats.
Topics: Animals; Clove Oil; Diabetes Mellitus, Experimental; Erectile Dysfunction; Eugenol; Glyburide; In Vi | 2020 |
Modulatory effect of tropisetron in the liver of streptozotocin-induced diabetes in rats: biochemical and histological evidence.
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Glutathione Peroxidase; Glyburide; Liver; Ma | 2020 |
Identification and characterization of anti-diabetic principle in Senna alata (Linn.) flower using alloxan-induced diabetic male Wistar rats.
Topics: Alloxan; alpha-Amylases; Animals; Biomarkers; Blood Glucose; Diabetes Mellitus, Experimental; Emodin | 2020 |
The effect of co-administration of berberine, resveratrol, and glibenclamide on xenobiotic metabolizing enzyme activities in diabetic rat liver.
Topics: Animals; Antioxidants; Berberine; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Diabetes Mellitu | 2022 |
The protective effect of green tea on diabetes-induced hepato-renal pathological changes: a histological and biochemical study.
Topics: Animals; Diabetes Complications; Diabetes Mellitus, Experimental; Glyburide; Liver; Male; Rats; Rats | 2023 |
The antidiabetic drug glibenclamide exerts direct retinal neuroprotection.
Topics: Administration, Oral; Animals; Chlorocebus aethiops; Diabetes Mellitus, Experimental; Diabetic Retin | 2021 |
Synergistic Effect of Omega-3 Fatty Acids and Oral-Hypoglycemic Drug on Lipid Normalization through Modulation of Hepatic Gene Expression in High Fat Diet with Low Streptozotocin-Induced Diabetic Rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; | 2020 |
Evaluation of Gamma Amino Butyric Acid (GABA) and Glibenclamide Combination Therapy in Streptozotocin Induced Diabetes.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; gamma-Aminobutyric Acid; Glyburide; Humans; | 2021 |
Curative Effect of Catechin Isolated from
Topics: alpha-Amylases; alpha-Glucosidases; Animals; Antioxidants; Benzothiazoles; Biphenyl Compounds; Blood | 2020 |
Stink bean (
Topics: Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Di | 2023 |
Myrianthus libericus: Possible mechanisms of hypoglycaemic action and in silico prediction of pharmacokinetics and toxicity profile of its bioactive metabolite, friedelan-3-one.
Topics: alpha-Amylases; Animals; Cell Line; Computer Simulation; Diabetes Mellitus, Experimental; Glucose; G | 2021 |
The effectiveness comparisons of eugenosedin-A, glibenclamide and pioglitazone on diabetes mellitus induced by STZ/NA and high-fat diet in SHR.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diet, High-Fat; Glyburide; Hypertension; Hy | 2021 |
Inhibitory effect of Salvia coccinea on inflammatory responses through NF-κB signaling pathways in THP-1 cells and acute rat diabetes mellitus.
Topics: Active Transport, Cell Nucleus; Administration, Oral; Animals; Antioxidants; Blood Glucose; Catalase | 2021 |
Design, Synthesis, Characterization and in vivo Antidiabetic Activity Evaluation of Some Chalcone Derivatives.
Topics: Animals; Chalcones; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Drug Design; | 2021 |
Histopathological and biochemical assessments of Costus afer stem on alloxan-induced diabetic rats.
Topics: Alloxan; Animals; Biomarkers; Body Weight; Costus; Diabetes Mellitus, Experimental; Glyburide; Hyper | 2017 |
Beneficial effects of tyrosol on altered glycoprotein components in streptozotocin-induced diabetic rats.
Topics: Administration, Oral; Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Glyburi | 2017 |
Comparison of the Effects of Mitiglinide and Glibenclamide Administered in Combination with the Dipeptidyl Peptidase-IV Inhibitor Sitagliptin in Rats with Streptozotocin-Nicotinamide-Induced Type 2 Diabetes.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dipeptidyl-Pepti | 2017 |
Coenzyme Q10 and niacin mitigate streptozotocin- induced diabetic encephalopathy in a rat model.
Topics: Animals; Antioxidants; Blood Glucose; Brain Diseases; Cholinesterase Inhibitors; Diabetes Mellitus, | 2017 |
Selective ER-α agonist alleviates vascular endothelial dysfunction in ovariectomized type 2 diabetic rats.
Topics: Acetylcholine; Animals; Aorta; Biomarkers; Blood Glucose; Body Weight; Diabetes Mellitus, Experiment | 2018 |
Galangin, a natural flavonoid reduces mitochondrial oxidative damage in streptozotocin-induced diabetic rats.
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Enzymes; Flavonoids; Glutathione; Glutathion | 2018 |
Murraya paniculata (L.) (Orange Jasmine): Potential Nutraceuticals with Ameliorative Effect in Alloxan-Induced Diabetic Rats.
Topics: Alloxan; Animals; Blood Glucose; Cholesterol; Diabetes Mellitus, Experimental; Dietary Supplements; | 2017 |
Anti-Hyperglycaemic Effect of Cleome Rutidosperma in Alloxan-Induced Diabetic Albino Rats.
Topics: Animals; Blood Glucose; Cleome; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; G | 2017 |
Combination of Rheum ribes and Metformin Against Diabetes, Thermal Hyperalgesia, and Tactile Allodynia in a Mice Model.
Topics: Animals; Antioxidants; Biomarkers; Blood Glucose; Diabetes Mellitus, Experimental; Glyburide; Hypera | 2018 |
Report - Antidiabetic effects of native date fruit Aseel (Phoenix dactylifera L.) in normal and hyperglycemic rats.
Topics: Alloxan; Animals; Biomarkers; Blood Glucose; Diabetes Mellitus, Experimental; Fruit; Glyburide; Hype | 2017 |
Antidiabetic and in vitro antioxidant effects of hydromethanol extract of Paullinia pinnata root bark in alloxan-induced diabetic rat.
Topics: Animals; Antioxidants; Biphenyl Compounds; Blood Glucose; Diabetes Mellitus, Experimental; Glucose T | 2017 |
Evaluation of hepatic glycogen content, some haematological and biochemical parameters of alloxan-induced diabetic rats treated with combinations of glibenclamide and G. latifolium extract.
Topics: Animals; Apocynaceae; Blood Cells; Blood Urea Nitrogen; Creatinine; Diabetes Mellitus, Experimental; | 2017 |
The protection of resveratrol and its combination with glibenclamide, but not berberine on the diabetic hearts against reperfusion-induced arrhythmias: the role of myocardial K
Topics: Animals; Arrhythmias, Cardiac; Berberine; Diabetes Mellitus, Experimental; Dose-Response Relationshi | 2019 |
Betanin exhibits significant potential as an antihyperglycemic and attenuating the glycoprotein components in streptozotocin-nicotinamide-induced experimental rats.
Topics: Animals; Betacyanins; Biomarkers; Body Weight; Combined Modality Therapy; Diabetes Mellitus, Experim | 2018 |
Evaluation of the Anti-Diabetic Activity of Polysaccharide from Cordyceps cicadae in Experimental Diabetic Rats.
Topics: Administration, Oral; Alloxan; Animals; Antioxidants; Cordyceps; Diabetes Mellitus, Experimental; Gl | 2018 |
Chronic palmitic acid-induced lipotoxicity correlates with defective trafficking of ATP sensitive potassium channels in pancreatic β cells.
Topics: Animals; Cell Line, Tumor; Diabetes Mellitus, Experimental; Glyburide; Insulin-Secreting Cells; Insu | 2018 |
Effects of amlodipine and valsartan on glibenclamide-treated streptozotocin-induced diabetic rats.
Topics: Amlodipine; Animals; Antihypertensive Agents; Biomarkers; Blood Glucose; Diabetes Mellitus, Experime | 2018 |
Glibenclamide Mini-tablets with an Enhanced Pharmacokinetic and Pharmacodynamic Performance.
Topics: Animals; Biological Availability; Diabetes Mellitus, Experimental; Glyburide; Humans; Hypoglycemic A | 2018 |
Inhibition of liver mitochondrial membrane permeability transition pore opening by quercetin and vitamin E in streptozotocin-induced diabetic rats.
Topics: Administration, Oral; Animals; Antioxidants; Apoptosis; Diabetes Mellitus, Experimental; Glucose; Gl | 2018 |
New Quinazoline-Sulfonylurea Conjugates: Design, Synthesis and Hypoglycemic Activity.
Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Down-Regulation; Female; Glucose T | 2019 |
In vivo Assessment of Combined Effects of Glibenclamide and Losartan in Diabetic Rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glutathione; Glutathione Peroxidase; Glutat | 2019 |
Vindoline effectively ameliorated diabetes-induced hepatotoxicity by docking oxidative stress, inflammation and hypertriglyceridemia in type 2 diabetes-induced male Wistar rats.
Topics: Animals; Blood Glucose; Catharanthus; Cytokines; Diabetes Mellitus, Experimental; Diabetes Mellitus, | 2019 |
Multi-target antidiabetic mechanisms of mexicanolides from Swietenia humilis.
Topics: Animals; Cell Line; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Drug Synergis | 2019 |
Comparing The Effect Of Electroacupuncture And Glibenclamide On Blood Glucose Level And Histological Markers Of Pancreas In Streptozotocin-Induced Diabetic Rats.
Topics: Acupuncture Points; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Electroacupuncture; Gly | 2020 |
Pharmacodynamic interaction of cumin seeds (Cuminum cyminum L.) with glyburide in diabetes.
Topics: Animals; Biomarkers, Pharmacological; Cuminum; Diabetes Mellitus, Experimental; Glucose Tolerance Te | 2019 |
Pharmacological evaluation of hyperin for antihyperglycemic activity and effect on lipid profile in diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Glucose Tolerance Test; Glyburide; Glycogen; Hexokinase; H | 2013 |
Effect of iridoid glucoside on plasma lipid profile, tissue fatty acid changes, inflammatory cytokines, and GLUT4 expression in skeletal muscle of streptozotocin-induced diabetic rats.
Topics: Animals; Blotting, Western; Cholesterol; Cytokines; Diabetes Mellitus, Experimental; Enzyme-Linked I | 2013 |
The evaluation of the hypoglycemic effect of soft drink leaf extract of Phyllanthus amarus (Euphorbiaceae) in rats.
Topics: Animals; Blood Cell Count; Blood Glucose; Cholesterol; Diabetes Mellitus, Experimental; Glucose Tole | 2014 |
Antihyperglycemic and antihyperlipidemic effects of newly synthesized glibenclamide analogues on streptozotocin-diabetic rats.
Topics: Animals; Blood Glucose; Cholesterol, HDL; Cholesterol, LDL; Diabetes Mellitus, Experimental; Glyburi | 2013 |
Novel drug delivery system of plant extract for the management of diabetes: an antidiabetic study.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dietary Supplements; Drug Delivery Systems; | 2013 |
Anti-diabetic activities of the methanol leaf extracts of Hymenocardia acida (tul.) in alloxan-induced diabetic rats.
Topics: Animals; Biomarkers; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Euphorbiacea | 2012 |
Analysis of the mechanisms underlying the antinociceptive effect of epicatechin in diabetic rats.
Topics: Analgesics; Animals; Biphenyl Compounds; Catechin; Diabetes Mellitus, Experimental; Dose-Response Re | 2013 |
Protective effect of gallic acid on alloxan-induced oxidative stress and osmotic fragility in rats.
Topics: Alloxan; Animals; Antioxidants; Biomarkers; Blood Glucose; Catalase; Cytoprotection; Diabetes Mellit | 2014 |
Antidiabetic and antihyperlipidemic activity of asiatic acid in diabetic rats, role of HMG CoA: in vivo and in silico approaches.
Topics: Acyl Coenzyme A; Animals; Blood Glucose; Centella; Cholesterol; Diabetes Mellitus, Experimental; Gly | 2014 |
Influence of Allium sativum extract on the hypoglycemic activity of glibenclamide: an approach to possible herb-drug interaction.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Drug Synergism; Garlic; Glucos | 2013 |
Chemical characterization of Centaurium erythrea L. and its effects on carbohydrate and lipid metabolism in experimental diabetes.
Topics: Animals; Blood Glucose; Carbohydrate Metabolism; Centaurium; Chromatography, High Pressure Liquid; D | 2014 |
Synthesis and investigating hypoglycemic and hypolipidemic activities of some glibenclamide analogues in rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glyburide; Hypoglycemic Agents; Hypolipidem | 2014 |
Blood glucose-lowering effect of Tectona grandis flowers in type 2 diabetic rats: a study on identification of active constituents and mechanisms for antidiabetic action.
Topics: alpha-Amylases; alpha-Glucosidases; Animals; Biomarkers; Blood Glucose; Body Weight; Cell Line; Diab | 2014 |
Evaluation of the properties of Gongronema latifolium in phospholipon 90H based solid lipid microparticles (SLMs): an antidiabetic study.
Topics: Administration, Oral; Animals; Apocynaceae; Blood Glucose; Capsules; Diabetes Mellitus, Experimental | 2014 |
Effect of Carthamus tinctorius (Safflower) on fasting blood glucose and insulin levels in alloxan induced diabetic rabbits.
Topics: Animals; Blood Glucose; Carthamus tinctorius; Diabetes Mellitus, Experimental; Flowers; Glyburide; H | 2014 |
Biochemical and histopathological study of the anti-hyperglycemic and anti-hyperlipidemic effects of cornelian cherry (Cornus mas L.) in alloxan-induced diabetic rats.
Topics: Alkaline Phosphatase; Alloxan; Animals; Anthocyanins; Blood Glucose; Chemical and Drug Induced Liver | 2014 |
Glibenclamide treatment modulates the expression and localization of myosin-IIB in diabetic rat brain.
Topics: Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; Gene Expression Regulation; Glybur | 2014 |
Curcumin ameliorates streptozotocin-induced heart injury in rats.
Topics: Animals; Antioxidants; Blood Glucose; Curcumin; Diabetes Mellitus, Experimental; Glutathione; Glybur | 2014 |
Subacute antidiabetic and in vivo antioxidant effects of methanolic extract of Bridelia micrantha (Hochst Baill) leaf on alloxan-induced hyperglycaemic rats.
Topics: Alloxan; Animals; Antioxidants; Blood Glucose; Catalase; Diabetes Mellitus, Experimental; Dose-Respo | 2014 |
Pharmacognostical standardization and antidiabetic activity of Syzygium cumini (Linn.) barks (Myrtaceae) on streptozotocin-induced diabetic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Female; Glucose Tolerance Test; Glyburide; | 2014 |
Onset of diabetes modulates the airway smooth muscle reactivity of guinea pigs: role of epithelial mediators.
Topics: Acetylcholine; Animals; Bronchi; Bronchoconstriction; Cyclooxygenase Inhibitors; Diabetes Mellitus, | 2014 |
Gating behavior of endoplasmic reticulum potassium channels of rat hepatocytes in diabetes.
Topics: Adenosine Triphosphate; Animals; Biophysical Phenomena; Blood Glucose; Diabetes Mellitus, Experiment | 2014 |
Effects of glucagon-like peptide-1 in diabetic rat small resistance arteries.
Topics: 4-Aminopyridine; Animals; Apamin; Arteries; Charybdotoxin; Cyclic GMP; Diabetes Mellitus, Experiment | 2014 |
Hypoglycemic properties of some preparations and compounds from Artemisia ludoviciana Nutt.
Topics: Administration, Oral; alpha-Glucosidases; Animals; Artemisia; Blood Glucose; Diabetes Mellitus, Expe | 2014 |
Administration of Lupinus albus gamma conglutin (Cγ) to n5 STZ rats augmented Ins-1 gene expression and pancreatic insulin content.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Gene Expression; | 2014 |
Hypoglycemic effect of Rhizophora mucronata in streptozotocin induced diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Female; Glyburide; Hypoglycemi | 2014 |
Glibenclamide attenuates myocardial injury by lipopolysaccharides in streptozotocin-induced diabetic mice.
Topics: Animals; Cells, Cultured; Diabetes Mellitus, Experimental; Endotoxemia; Glyburide; Heart Injuries; H | 2014 |
Reversible changes in pancreatic islet structure and function produced by elevated blood glucose.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Disease Models, Animal; Electrophysiology; | 2014 |
Chamomile tea: herbal hypoglycemic alternative for conventional medicine.
Topics: Animals; Beverages; Biomarkers; Blood Glucose; Body Weight; Chamomile; Diabetes Mellitus, Experiment | 2014 |
Morphological changes in the pancreas and glucose reduction of the aqueous extract of Costus afer leaf on alloxan-induced diabetic rats.
Topics: Alloxan; Animals; Blood Glucose; Costus; Diabetes Mellitus, Experimental; Dose-Response Relationship | 2015 |
Anti-hyperglycemic and anti-hyperlipidemic effects of Vaccinium myrtillus fruit in experimentally induced diabetes (antidiabetic effect of Vaccinium myrtillus fruit).
Topics: Animals; Blood Glucose; C-Reactive Protein; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Cholest | 2016 |
The combination of zinc and glibenclamide limits cardiovascular complications in diabetic rats via multiple mechanisms.
Topics: Animals; Cardiovascular Diseases; Diabetes Complications; Diabetes Mellitus, Experimental; Glyburide | 2015 |
Antidiabetic and antidyslipidemic activities of aqueous leaf extract of Dioscoreophyllum cumminsii (Stapf) Diels in alloxan-induced diabetic rats.
Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glyburide; Hypoglycemic Agents; Hy | 2015 |
Immunohistochemistry, histopathology, and biomarker studies of swertiamarin, a secoiridoid glycoside, prevents and protects streptozotocin-induced β-cell damage in Wistar rat pancreas.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glyburide; Heart; Hypoglycemic Agents; Immu | 2015 |
Influence of kaempferol, a flavonoid compound, on membrane-bound ATPases in streptozotocin-induced diabetic rats.
Topics: Adenosine Triphosphatases; Administration, Oral; Animals; Ca(2+) Mg(2+)-ATPase; Calcium-Transporting | 2015 |
Methanolic leaf exctract of Otostegia integrifolia Benth reduces blood glucose levels in diabetic, glucose loaded and normal rodents.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Ethiopia; Glucose; Glucose Tolerance Test; | 2015 |
Antioxidant, α-glucosidase inhibitory activity and sub-chronic toxicity of Derris reticulata extract: its antidiabetic potential.
Topics: Acarbose; Alloxan; alpha-Glucosidases; Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Blo | 2015 |
Antidiabetic Effects of Aqueous Infusions of Artemisia herba-alba and Ajuga iva in Alloxan-Induced Diabetic Rats.
Topics: Ajuga; Alloxan; Animals; Apigenin; Artemisia; Blood Glucose; Chlorogenic Acid; Diabetes Mellitus, Ex | 2015 |
The Effects of Solvent Polarity on Hypoglycemic and Hypolipidemic Activities of Securigera Securidaca (L.) Seeds.
Topics: Alkaloids; Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Flavonoids; Glybur | 2016 |
Effect of hydroalcoholic leaves extract of Indigofera spicata Forssk. on blood glucose level of normal, glucose loaded and diabetic rodents.
Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glyburide; Hypoglycemic Agents; In | 2015 |
Effects of Thymoquinone on the Pharmacokinetics and Pharmacodynamics of Glibenclamide in a Rat Model.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzoquinones; Blood Glucose; Cytochrome P-450 CYP3A; Cytoch | 2015 |
Duration effect of Acacia nilotica leaves extract and glibenclamide as hypolipidaemic and hypoglycaemic activity in alloxan induced diabetic rats.
Topics: Acacia; Alloxan; Animals; Diabetes Mellitus, Experimental; Glyburide; Hypoglycemic Agents; Lipids; M | 2015 |
Antidiabetic, antihyperlipidaemic, and antioxidant activity of Syzygium densiflorum fruits in streptozotocin and nicotinamide-induced diabetic rats.
Topics: Animals; Antioxidants; Biomarkers; Blood Glucose; Cell Proliferation; Diabetes Mellitus, Experimenta | 2016 |
Pharmacokinetic and Pharmacodynamic Interaction of Boswellic Acids and Andrographolide with Glyburide in Diabetic Rats: Including Its PK/PD Modeling.
Topics: Animals; Area Under Curve; Biological Availability; Cytochrome P-450 CYP3A; Diabetes Mellitus, Exper | 2016 |
Fasiglifam/TAK-875, a Selective GPR40 Agonist, Improves Hyperglycemia in Rats Unresponsive to Sulfonylureas and Acts Additively with Sulfonylureas.
Topics: Animals; Benzofurans; Blood Glucose; Diabetes Mellitus, Experimental; Drug Synergism; Glucose Tolera | 2016 |
Comparative Study of the Antioxidant Effects of Metformin, Glibenclamide, and Repaglinide in Alloxan-Induced Diabetic Rats.
Topics: Alloxan; Animals; Antioxidants; Biomarkers; Blood Glucose; Carbamates; Catalase; Diabetes Complicati | 2016 |
Protective and hypoglycemic effects of celery seed on streptozotocin-induced diabetic rats: experimental and histopathological evaluation.
Topics: Alanine Transaminase; Animals; Apium; Aspartate Aminotransferases; Blood Glucose; Diabetes Mellitus, | 2016 |
Acute hypoglycemic effect and phytochemical composition of Ageratina petiolaris.
Topics: Ageratina; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucose Tolerance Test; Glyburid | 2016 |
No Additional Effect of DPP-4 Inhibitor on Preventing Atrial Fibrosis in Streptozotocin-Induced Diabetic Rat as Compared With Sulfonylurea.
Topics: Adamantane; Animals; Anti-Inflammatory Agents; Atrial Fibrillation; Diabetes Mellitus, Experimental; | 2016 |
Evaluation of the antidiabetic and antioxidant properties of Morinda lucida stem bark extract in streptozotocin intoxicated rats.
Topics: Animals; Antioxidants; Biomarkers; Blood Glucose; Diabetes Mellitus, Experimental; Erythrocytes; Glu | 2016 |
Hypoglycaemic activity of ethanolic extract of Garcinia mangostana Linn. in normoglycaemic and streptozotocin-induced diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Ethanol; Garcinia mangos | 2016 |
A Novel Diphenylthiosemicarbazide Is a Potential Insulin Secretagogue for Anti-Diabetic Agen.
Topics: Administration, Oral; Amino Acids, Cyclic; Animals; Blood Glucose; Calcium; Cell Line; Diabetes Mell | 2016 |
Deterioration of epithelium mediated mechanisms in diabetic-antigen sensitized airways of guinea pigs.
Topics: Acetylcholine; Animals; Antigens, Bacterial; Bacterial Proteins; Bronchial Hyperreactivity; Bronchoc | 2016 |
Protective effects of Ficus carica leaves on glucose and lipids levels, carbohydrate metabolism enzymes and β-cells in type 2 diabetic rats.
Topics: Acetates; Animals; Biomarkers; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Ty | 2017 |
Evaluation of the sub-chronic toxicity profile of the corm of Xanthosoma sagittifolium on hematology and biochemistry of alloxan-induced diabetic Wistar rats.
Topics: Animals; Blood Glucose; Cholesterol, HDL; Cholesterol, LDL; Diabetes Mellitus, Experimental; Dyslipi | 2017 |
A novel steroid from Elephantopus scaber L. an ethnomedicinal plant with antidiabetic activity.
Topics: Animals; Asteraceae; Blood Glucose; Diabetes Mellitus, Experimental; Ergosterol; Glyburide; Hypoglyc | 2009 |
Change in long-spacing collagen in Descemet's membrane of diabetic Goto-Kakizaki rats and its suppression by antidiabetic agents.
Topics: Animals; Collagen; Cornea; Cyclohexanes; Descemet Membrane; Diabetes Mellitus, Experimental; Diabeti | 2008 |
Effect of ethanolic extract of Juglans regia L. on blood sugar in diabetes-induced rats.
Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glyburide; Hypoglycemic Agents; In | 2008 |
Antidiabetic effect of Olea europaea L. in normal and diabetic rats.
Topics: Administration, Oral; Animals; Diabetes Mellitus, Experimental; Glyburide; Hypoglycemic Agents; Insu | 2009 |
Secondary consequences of beta cell inexcitability: identification and prevention in a murine model of K(ATP)-induced neonatal diabetes mellitus.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Blood Glucose; Diabetes Mellitus, Experimental; G | 2009 |
Antidiabetic effects of dipeptidyl peptidase-IV inhibitors and sulfonylureas in streptozotocin-nicotinamide-induced mildly diabetic mice.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dipeptidyl-Pepti | 2009 |
Cytochrome P450 metabolites of arachidonic acid play a role in the enhanced cardiac dysfunction in diabetic rats following ischaemic reperfusion injury.
Topics: 8,11,14-Eicosatrienoic Acid; Amidines; Animals; Arachidonic Acid; Blood Glucose; Body Weight; Corona | 2009 |
Hypoglycaemic and hypolipidaemic effects of Withania somnifera root and leaf extracts on alloxan-induced diabetic rats.
Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glyburide; Glycosuria; Hemoglobins | 2009 |
Hypoglycemic activity of dried extracts of Bauhinia forficata Link.
Topics: Animals; Bauhinia; Blood Glucose; Chemistry, Pharmaceutical; Desiccation; Diabetes Mellitus, Experim | 2010 |
Hypoglycemic effect of aqueous extract of seabuckthorn (Hippophae rhamnoides L.) seed residues in streptozotocin-induced diabetic rats.
Topics: Animals; Antioxidants; Blood Glucose; Body Weight; Cholesterol; Diabetes Mellitus, Experimental; Gly | 2010 |
Protective effect of Gymnema montanum against renal damage in experimental diabetic rats.
Topics: Animals; Antioxidants; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetic Nephrop | 2009 |
Further evaluation of antihyperglycaemic activity of Hunteria umbellata (K. Schum) Hallier f. seed extract in experimental diabetes.
Topics: Animals; Apocynaceae; Blood Glucose; Cholesterol; Diabetes Mellitus, Experimental; Dose-Response Rel | 2009 |
Aqueous extract of Abutilon indicum Sweet inhibits glucose absorption and stimulates insulin secretion in rodents.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dietary Sucrose; Dose-Response Relationship | 2009 |
The anti-hyperglycemic effect of plants in genus Gynura Cass.
Topics: 1-Butanol; Acetates; Alloxan; Animals; Asteraceae; Blood Glucose; Diabetes Mellitus, Experimental; D | 2009 |
Antidiabetic and antihyperlipidemic activity of ethyl acetate:isopropanol (1:1) fraction of Vernonia anthelmintica seeds in streptozotocin induced diabetic rats.
Topics: 2-Propanol; Acetates; Animals; Blood Glucose; Chemical Fractionation; Chromatography, Gel; Diabetes | 2010 |
Evaluation of hypoglycemic and anti-hyperglycemic potential of Tridax procumbens (Linn.).
Topics: Animals; Asteraceae; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Glucose Intoleranc | 2009 |
ATP-sensitive potassium channels contribute to the time-dependent alteration in the pentylenetetrazole-induced seizure threshold in diabetic mice.
Topics: Analysis of Variance; Animals; Blood Glucose; Body Weight; Cromakalim; Diabetes Mellitus, Experiment | 2010 |
Volume-sensitive outwardly rectifying chloride channel in white adipocytes from normal and diabetic mice.
Topics: Adipocytes, White; Animals; Cell Size; Cells, Cultured; Chloride Channels; Diabetes Mellitus, Experi | 2010 |
Antidiabetic activity of cycloart-23-ene-3beta, 25-diol (B2) isolated from Pongamia pinnata (L. Pierre) in streptozotocin-nicotinamide induced diabetic mice.
Topics: Animals; Diabetes Mellitus, Experimental; Glucose Tolerance Test; Glyburide; Hypoglycemic Agents; Mi | 2010 |
Antihyperglycemic and antihyperlipidemic activities of methanol:water (4:1) fraction isolated from aqueous extract of Syzygium alternifolium seeds in streptozotocin induced diabetic rats.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Blood Glucose; Che | 2010 |
Antioxidant effect of dietary supplement Withania somnifera L. reduce blood glucose levels in alloxan-induced diabetic rats.
Topics: Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Dietary Supplements; Flavonoi | 2010 |
Antihyperglycaemic activity of aqueous leaf extract of Combretum micranthum (Combretaceae) in normal and alloxan-induced diabetic rats.
Topics: Alloxan; Animals; Blood Glucose; Combretum; Diabetes Mellitus, Experimental; Dose-Response Relations | 2010 |
Biochemical evaluation of the protective effect of Aegle marmelos (L.), Corr. leaf extract on tissue antioxidant defense system and histological changes of pancreatic beta-cells in streptozotocin-induced diabetic rats.
Topics: Administration, Oral; Aegle; Animals; Antioxidants; Blood Glucose; Ceruloplasmin; Diabetes Mellitus, | 2010 |
Ameliorative effect of Cassia auriculata L. leaf extract on glycemic control and atherogenic lipid status in alloxan-induced diabetic rabbits.
Topics: Alloxan; Animals; Atherosclerosis; Blood Glucose; Cassia; Cholesterol, HDL; Cholesterol, LDL; Diabet | 2009 |
Impact of hyperlipidemia on plasma protein binding and hepatic drug transporter and metabolic enzyme regulation in a rat model of gestational diabetes.
Topics: Animals; Binding, Competitive; Biological Transport; Blood Proteins; Carrier Proteins; Chromatograph | 2010 |
Anti-hyperglycemic effect of 11-hydroxypalmatine, a palmatine derivative from Stephania glabra tubers.
Topics: Alkaloids; Alloxan; Animals; Berberine Alkaloids; Blood Glucose; Diabetes Mellitus, Experimental; Gl | 2010 |
Antihyperlipidemic activity of Helicteres isora fruit extract on streptozotocin induced diabetic male Wistar rats.
Topics: Animals; Diabetes Mellitus, Experimental; Fruit; Glyburide; Hyperlipidemias; Hypoglycemic Agents; Hy | 2010 |
Hypolipidaemic and antioxidant effects of fruits of Musa AAA (Chenkadali) in alloxan induced diabetic rats.
Topics: Alanine Transaminase; Alloxan; Animals; Antioxidants; Cholesterol; Diabetes Mellitus, Experimental; | 2010 |
Antihyperglycemic effect of protocatechuic acid on streptozotocin-diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Glyburide; Glycated Hemoglobin | 2010 |
SRMS142-based solid lipid microparticles: application in oral delivery of glibenclamide to diabetic rats.
Topics: Administration, Oral; Animals; Ascorbic Acid; Blood Glucose; Calorimetry, Differential Scanning; Che | 2010 |
Antioxidant protective effect of glibenclamide and metformin in combination with honey in pancreas of streptozotocin-induced diabetic rats.
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Gene Expression Regulation, Enzymologic; Gly | 2010 |
The differentiating effect of glimepiride and glibenclamide on paraoxonase 1 and platelet-activating factor acetylohydrolase activity.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Animals; Antioxidants; Aryldialkylphosphatase; Diabe | 2010 |
Hypoglycemic activity of Ziziphus mauritiana aqueous ethanol seed extract in alloxan-induced diabetic mice.
Topics: Administration, Oral; Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dose-Respons | 2010 |
Antidiabetic effect of Raphanus sativus root juice.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Glucose T | 2011 |
Effect of Cyclea peltata Lam. roots aqueous extract on glucose levels, lipid profile, insulin, TNF-alpha and skeletal muscle glycogen in type 2 diabetic rats.
Topics: Animals; Blood Glucose; Cyclea; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Drug Eva | 2010 |
Hypoglycemic effect of a leaf extract of Pseuderanthemum palatiferum (Nees) Radlk. in normal and streptozotocin-induced diabetic rats.
Topics: Acanthaceae; Animals; Blood Glucose; Blood Urea Nitrogen; Cholesterol, LDL; Diabetes Mellitus, Exper | 2010 |
Effects of Momordica charantia on pancreatic histopathological changes associated with streptozotocin-induced diabetes in neonatal rats.
Topics: Administration, Oral; Animals; Animals, Newborn; Blood Glucose; Diabetes Mellitus, Experimental; Fru | 2011 |
Antidiabetic and antioxidant potential of β-sitosterol in streptozotocin-induced experimental hyperglycemia.
Topics: Animals; Antioxidants; Blood Glucose; Catalase; Diabetes Mellitus, Experimental; Dose-Response Relat | 2011 |
Antihyperglycemic activity of bacosine, a triterpene from Bacopa monnieri, in alloxan-induced diabetic rats.
Topics: alpha-Tocopherol; Animals; Antioxidants; Bacopa; Blood Glucose; Catalase; Diabetes Mellitus, Experim | 2011 |
Influence of atorvastatin on the pharmacokinetics and pharmacodynamics of glyburide in normal and diabetic rats.
Topics: Animals; Anticholesteremic Agents; Area Under Curve; Atorvastatin; Blood Glucose; Cytochrome P-450 E | 2011 |
Ameliorative effects of glycyrrhizin on streptozotocin-induced diabetes in rats.
Topics: Animals; Blood Glucose; Catalase; Cholesterol; Diabetes Mellitus, Experimental; Free Radicals; Fruct | 2011 |
Hypoglycemic activity of Erythrina variegata leaf in streptozotocin-induced diabetic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Drug Eval | 2011 |
Comparison of antioxidant effects of honey, glibenclamide, metformin, and their combinations in the kidneys of streptozotocin-induced diabetic rats.
Topics: Animals; Antioxidants; Catalase; Diabetes Mellitus, Experimental; Glutathione Peroxidase; Glutathion | 2011 |
Alliin obtained from leaf extract of garlic grown under in situ conditions possess higher therapeutic potency as analyzed in alloxan-induced diabetic rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Cysteine; Diabetes Mellitus, Experimenta | 2011 |
Glibenclamide or metformin combined with honey improves glycemic control in streptozotocin-induced diabetic rats.
Topics: Animals; Bilirubin; Blood Glucose; Body Weight; Creatinine; Diabetes Mellitus, Experimental; Eating; | 2011 |
Acacia nilotica leave extract and glyburide: comparison of fasting blood glucose, serum insulin, beta-thromboglubulin levels and platelet aggregation in streptozotocin induced diabetic rats.
Topics: Acacia; Animals; beta-Thromboglobulin; Blood Glucose; Diabetes Mellitus, Experimental; Glyburide; Hy | 2011 |
Antidiabetic activity of standardized extract of Quassia amara in nicotinamide-streptozotocin-induced diabetic rats.
Topics: Animals; Blood Glucose; Cholesterol; Diabetes Mellitus, Experimental; Glucose Tolerance Test; Glybur | 2011 |
Pectin from Passiflora edulis shows anti-inflammatory action as well as hypoglycemic and hypotriglyceridemic properties in diabetic rats.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Aspartate Aminotransferases; Biomarkers; Ca | 2011 |
Regulation of cardiac oxidative stress and lipid peroxidation in streptozotocin-induced diabetic rats treated with aqueous extract of Pimpinella tirupatiensis tuberous root.
Topics: Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Glyburide; Hypoglycemic Agent | 2013 |
Influence of 3-hydroxymethyl xylitol, a novel antidiabetic compound isolated from Casearia esculenta (Roxb.) root, on glycoprotein components in streptozotocin-diabetic rats.
Topics: Administration, Oral; Animals; Blood Glucose; Casearia; Diabetes Mellitus, Experimental; Fibronectin | 2011 |
Evaluation of the anti-diabetic properties of Mucuna pruriens seed extract.
Topics: Administration, Oral; Alloxan; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; | 2011 |
Hypoglycemic activity of Thai medicinal plants selected from the Thai/Lanna Medicinal Recipe Database MANOSROI II.
Topics: Analysis of Variance; Animals; Antioxidants; Blood Glucose; Databases, Factual; Diabetes Mellitus, E | 2011 |
Compositional analysis and in vivo anti-diabetic activity of wild Algerian Marrubium vulgare L. infusion.
Topics: Algeria; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Dose-Response Relatio | 2012 |
Antihyperglycemic effect of iridoid glucoside, isolated from the leaves of Vitex negundo in streptozotocin-induced diabetic rats with special reference to glycoprotein components.
Topics: Administration, Oral; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Fucose; Glyburide; Gl | 2012 |
Pharmacological interaction between gabapentin and glibenclamide in the formalin test in the diabetic rat.
Topics: Amines; Animals; Cyclohexanecarboxylic Acids; Diabetes Mellitus, Experimental; Drug Interactions; Ga | 2010 |
Urinary bladder relaxation through activation of opioid μ-receptors induced by loperamide is increased in diabetic rats.
Topics: Animals; Antidiarrheals; Cells, Cultured; Diabetes Mellitus, Experimental; Glyburide; Hypoglycemic A | 2012 |
Effect of Delonix regia leaf extract on glucose tolerance in glucose-induced hyperglycemic mice.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Fabaceae; | 2011 |
Evaluation of Neolamarckia cadamba (Roxb.) Bosser leaf extract on glucose tolerance in glucose-induced hyperglycemic mice.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucose Tolerance Test; Glyburide; Hypoglyc | 2011 |
Antioxidant activity and protection of pancreatic β-cells by embelin in streptozotocin-induced diabetes.
Topics: Animals; Antioxidants; Ascorbic Acid; Benzoquinones; Blood Glucose; Catalase; Diabetes Mellitus, Exp | 2012 |
Comparative effects of zinc, selenium and vitamin E or their combination on carbohydrate metabolizing enzymes and oxidative stress in streptozotocin induced-diabetic rats.
Topics: Animals; Antioxidants; Blood Chemical Analysis; Blood Glucose; Carbohydrate Metabolism; Diabetes Mel | 2012 |
Antihyperglycemic and antioxidant activities of medicinal plant Stereospermum suaveolens in streptozotocin-induced diabetic rats.
Topics: Administration, Oral; Animals; Antioxidants; Bignoniaceae; Biomarkers; Blood Glucose; Body Weight; D | 2009 |
Bioassay-guided antidiabetic study of Phaleria macrocarpa fruit extract.
Topics: Animals; Biological Assay; Biological Transport; Blood Glucose; Chemical Fractionation; Diabetes Mel | 2012 |
Glibenclamide-pregnenolone derivative has greater hypoglycemic effects and biodistribution than glibenclamide-OH in alloxan-rats.
Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Drug Combinations; Female; Glyburi | 2012 |
Antioxidant, antihyperglycemic, and antihyperlipidemic effects of Coriandrum sativum leaf and stem in alloxan-induced diabetic rats.
Topics: Alloxan; Animals; Antioxidants; Blood Glucose; Cholesterol, HDL; Cholesterol, LDL; Coriandrum; Diabe | 2012 |
Hypoglycemic and antioxidant effects of leaf essential oil of Pelargonium graveolens L'Hér. in alloxan induced diabetic rats.
Topics: Alloxan; Animals; Antioxidants; Blood Glucose; Catalase; Diabetes Mellitus, Experimental; Glutathion | 2012 |
Synthesis, antidiabetic and hypolipidemic activities of new diethylamine and triethoxysilyl derivatives of tolbutamide on rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diethylamines; Glyburide; Hypoglycemic Agen | 2012 |
Potent hypoglycemic effect of Nigerian anti-diabetic medicinal plants.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Free Radical Scavengers; Glyburide; Hypogly | 2011 |
Antioxidative and hypolipidemic efficacy of alcoholic seed extract of Swietenia macrophylla in streptozotocin diabetic rats.
Topics: Administration, Oral; Animals; Antioxidants; Ascorbic Acid; Biomarkers; Blood Glucose; Catalase; Dia | 2011 |
Antihyperglycemic and hypolipidemic effects of α, β-amyrin, a triterpenoid mixture from Protium heptaphyllum in mice.
Topics: Animals; Blood Glucose; Cholesterol; Diabetes Mellitus, Experimental; Diet, High-Fat; Drug Discovery | 2012 |
Effect of Trigonella foenum-graecum seed powder on the antioxidant levels of high fat diet and low dose streptozotocin induced type II diabetic rats.
Topics: Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Di | 2012 |
Chebulic acid attenuates ischemia reperfusion induced biochemical alteration in diabetic rats.
Topics: Animals; Benzopyrans; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Dose-Response Relatio | 2013 |
Evaluating insulin secretagogues in a humanized mouse model with functional human islets.
Topics: Animals; Blood Glucose; Cyclohexanes; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Ex | 2013 |
Hypoglycaemic activity of Commelina africana and Ageratum conyzoides in relation to their mineral composition.
Topics: Ageratum; Animals; Blood Glucose; Commelina; Diabetes Mellitus, Experimental; Glyburide; Hypoglycemi | 2012 |
Preclinical evaluation of hypoglycemic activity of Ipomoea digitata tuber in streptozotocin-induced diabetic rats.
Topics: Administration, Oral; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetes | 2013 |
Comparison of the effects of glibenclamide on metabolic parameters, GLUT1 expression, and liver injury in rats with severe and mild streptozotocin-induced diabetes mellitus.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Gene Expression; Glucose Transporter Type 1 | 2012 |
Influence of diabetic state and that of different sulfonylureas on the size of myocardial infarction with and without ischemic preconditioning in rabbits.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Glyburide; Hypoglycemic Agents; Isc | 2002 |
Ischemic preconditioning protection against stunning in conscious diabetic sheep: role of glucose, insulin, sarcolemmal and mitochondrial KATP channels.
Topics: Action Potentials; Analysis of Variance; Animals; Decanoic Acids; Diabetes Mellitus, Experimental; D | 2002 |
Haemodynamic and metabolic effects of low daily dose sulphonylureas in diabetic dog hearts.
Topics: Animals; Blood Glucose; Blood Pressure; Coronary Circulation; Diabetes Mellitus, Experimental; Dogs; | 2002 |
Effects of chronic treatment with cromakalim and glibenclamide in alloxan-induced diabetic rats.
Topics: Animals; Antihypertensive Agents; Blood Glucose; Blood Pressure; Cromakalim; Diabetes Mellitus, Expe | 2002 |
Antioxidant effect of Phaseolus vulgaris in streptozotocin-induced diabetic rats.
Topics: Administration, Oral; Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Glutath | 2002 |
Glucose lowering efficacy of Ficus racemosa bark extract in normal and alloxan diabetic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Ficus; Glyburide; Hypoglycemic Agents; Leth | 2002 |
Effect of diabetes on pinacidil-induced antinociception in mice.
Topics: Animals; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Glyburide; Injections, I | 2002 |
The hypoglycemic effect of Phyllanthus sellowianus fractions in streptozotocin-induced diabetic mice.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Female; Flavonoids; Glyburide; Hypoglycemic | 2002 |
Decreased blood glucose excursion by nateglinide ameliorated neuropathic changes in Goto-Kakizaki rats, an animal model of non-obese type 2 diabetes.
Topics: Animals; Area Under Curve; Blood Glucose; Cyclohexanes; Diabetes Mellitus, Experimental; Diabetes Me | 2002 |
Antihyperglycaemic effect and acute toxicity of Securigera Securidaca L. seed extracts in mice.
Topics: Administration, Oral; Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dose-Respons | 2002 |
Pharmacodynamics, insulinotropic action and hypoglycemic effect of nateglinide and glibenclamide in normal and diabetic rats.
Topics: Animals; Blood Glucose; Cyclohexanes; Diabetes Mellitus, Experimental; Female; Glyburide; Hypoglycem | 2003 |
Antidiabetic and antioxidant effects of S-methyl cysteine sulfoxide isolated from onions (Allium cepa Linn) as compared to standard drugs in alloxan diabetic rats.
Topics: Animals; Antioxidants; Blood Glucose; Body Weight; Catalase; Cysteine; Diabetes Mellitus, Experiment | 2002 |
Antihyperglycaemic effect of Casearia esculenta root extracts in streptozotocin-induced diabetic rats.
Topics: Animals; Blood Glucose; Casearia; Diabetes Mellitus, Experimental; Fructose-Bisphosphatase; Glucose- | 2002 |
Effect of Cogent db, a herbal drug, on serum and tissue lipid metabolism in experimental hyperglycaemic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glyburide; Hypoglycemic Agents; Insulin; Li | 2003 |
Effect of Cassia auriculata flowers on blood sugar levels, serum and tissue lipids in streptozotocin diabetic rats.
Topics: Animals; Blood Glucose; Cassia; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; F | 2002 |
Effect of Gymnema montanum on blood glucose, plasma insulin, and carbohydrate metabolic enzymes in alloxan-induced diabetic rats.
Topics: Animals; Blood Glucose; Carbohydrate Metabolism; Diabetes Mellitus, Experimental; Fructose-Bisphosph | 2003 |
Role of K(+) channels in the coronary and renal vascular reactivity to vasopressin in diabetic rats.
Topics: Animals; Blood Glucose; Charybdotoxin; Coronary Vessels; Diabetes Mellitus, Experimental; Dose-Respo | 2003 |
Effect of Coccinia indica leaf extract on plasma antioxidants in streptozotocin- induced experimental diabetes in rats.
Topics: Administration, Oral; Animals; Ascorbic Acid; Blood Glucose; Ceruloplasmin; Cucurbitaceae; Diabetes | 2003 |
Hypoglycaemic effect of water extracts of Aegle marmelos fruits in streptozotocin diabetic rats.
Topics: Administration, Oral; Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Disease | 2003 |
Antidiabetic activity of Terminalia catappa Linn fruits.
Topics: Alloxan; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Fruit; Glyburide; Hyp | 2003 |
Antihyperglycemic effects of three extracts from Momordica charantia.
Topics: Alloxan; Animal Structures; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Di | 2003 |
Effect of Aegle marmelos fruits on normal and streptozotocin-diabetic Wistar rats.
Topics: Aegle; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Female; Glucose Tolerance Test; Glyb | 2003 |
The juice of fresh leaves of Catharanthus roseus Linn. reduces blood glucose in normal and alloxan diabetic rabbits.
Topics: Alloxan; Animals; Blood Glucose; Catharanthus; Diabetes Mellitus, Experimental; Dose-Response Relati | 2003 |
Effect of Hibiscus rosa sinensis Linn. ethanol flower extract on blood glucose and lipid profile in streptozotocin induced diabetes in rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Flowers; Glucose-6-Phosphatase; Glyburide; | 2003 |
Antidiabetic effect of Gymnema montanum leaves: effect on lipid peroxidation induced oxidative stress in experimental diabetes.
Topics: Animals; Antioxidants; Ascorbic Acid; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; E | 2003 |
Protective effects of ferulic acid on hyperlipidemic diabetic rats.
Topics: Administration, Oral; Animals; Coumaric Acids; Diabetes Mellitus, Experimental; Fatty Acids, Noneste | 2003 |
Long-term treatment with glibenclamide increases susceptibility of streptozotocin-induced diabetic rat heart to reperfusion-induced ventricular tachycardia.
Topics: Animals; Arrhythmias, Cardiac; Blood Glucose; Blood Pressure; Body Weight; Creatine Kinase; Diabetes | 2003 |
Hypoglycemic effect of Hypoxis hemerocallidea corm (African potato) aqueous extract in rats.
Topics: Administration, Oral; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glyburide; Hypoglycem | 2003 |
Comparison of the effects of glimepiride and glibenclamide on adipose tissue tumour necrosis factor-alpha mRNA expression and cellularity.
Topics: Adipose Tissue; Animals; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type | 2004 |
Antidiabetic activity of Bauhinia forficata extracts in alloxan-diabetic rats.
Topics: Animals; Bauhinia; Blood Glucose; Cholesterol; Cholesterol, HDL; Diabetes Mellitus, Experimental; Et | 2004 |
Radical scavenging effect of gliclazide in diabetic rats fed with a high cholesterol diet.
Topics: Animals; Blood Pressure; Cholesterol, Dietary; Diabetes Mellitus, Experimental; Diabetic Nephropathi | 2004 |
Insulin-independent induction of sterol regulatory element-binding protein-1c expression in the livers of streptozotocin-treated mice.
Topics: Animals; CCAAT-Enhancer-Binding Proteins; Cholesterol; Diabetes Mellitus, Experimental; DNA-Binding | 2004 |
Cardioprotection by glucose-insulin-potassium: dependence on KATP channel opening and blood glucose concentration before ischemia.
Topics: Adenosine Triphosphate; Animals; Blood Glucose; Cardiotonic Agents; Diabetes Mellitus, Experimental; | 2004 |
Synthesis and evaluation of fluorine-18 labeled glyburide analogs as beta-cell imaging agents.
Topics: Animals; Cell Line; Cells, Cultured; Diabetes Mellitus, Experimental; Fluorine Radioisotopes; Glybur | 2004 |
Glibenclamide transdermal patches: physicochemical, pharmacodynamic, and pharmacokinetic evaluations.
Topics: Administration, Cutaneous; Animals; Chemical Phenomena; Chemistry, Physical; Diabetes Mellitus, Expe | 2004 |
Effect of the sulphonylurea glibenclamide on liver and kidney antioxidant enzymes in streptozocin-induced diabetic rats.
Topics: Animals; Antioxidants; Body Weight; Catalase; Diabetes Mellitus, Experimental; Glyburide; Hypoglycem | 2004 |
Effect of scoparia dulcis (Sweet Broomweed) plant extract on plasma antioxidants in streptozotocin-induced experimental diabetes in male albino Wistar rats.
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Enzyme-Linked Immunosorbent Assay; Glyburide | 2004 |
Supplementation of fenugreek leaves lower lipid profile in streptozotocin-induced diabetic rats.
Topics: Animals; Blood Glucose; Cholesterol; Diabetes Mellitus, Experimental; Fatty Acids, Nonesterified; Fe | 2004 |
Protective role of Phaseolus vulgaris on changes in the fatty acid composition in experimental diabetes.
Topics: alpha-Linolenic Acid; Animals; Arachidonic Acid; Blood Glucose; Brain Chemistry; Cholesterol; Diabet | 2004 |
Protective effect of Eugenia jambolana seed kernel on tissue antioxidants in streptozotocin-induced diabetic rats.
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Glutathione; Glyburide; Hypoglycemic Agents; | 2004 |
Effect of Aegle marmelos Correa. (Bael) fruit extract on tissue antioxidants in streptozotocin diabetic rats.
Topics: Administration, Oral; Aegle; Animals; Antioxidants; Blood Glucose; Catalase; Diabetes Mellitus, Expe | 2003 |
Modulatory effect of Gymnema montanum leaf extract on brain antioxidant status and lipid peroxidation in diabetic rats.
Topics: Administration, Oral; Animals; Brain; Catalase; Conservation of Natural Resources; Diabetes Mellitus | 2004 |
The effects of the sulfonylurea glyburide on glutathione peroxidase, superoxide dismutase and catalase activities in the heart tissue of streptozotocin-induced diabetic rat.
Topics: Animals; Antioxidants; Blood Glucose; Body Weight; Catalase; Diabetes Mellitus, Experimental; Glutat | 2004 |
Modulatory effects of Aloe vera leaf gel extract on oxidative stress in rats treated with streptozotocin.
Topics: Alkaloids; Aloe; Animals; Anthraquinones; Blood Glucose; Carotenoids; Diabetes Mellitus, Experimenta | 2005 |
Hypoglycaemic and antidiabetic activity of acetonic extract of Vernonia colorata leaves in normoglycaemic and alloxan-induced diabetic rats.
Topics: Acetone; Administration, Oral; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Disease Mode | 2005 |
[Antidiabetic activity of Zizyphus mauritiana Lam (Rhamnaceae)].
Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Disease Models, Animal; Dose-Respo | 2000 |
Antidiabetic and antihyperlipemic effects of Clemeo felina.
Topics: Animals; Diabetes Mellitus, Experimental; Glyburide; Hypoglycemic Agents; Hypolipidemic Agents; Insu | 2005 |
Potential hypoglycemic effects of Chlorella in streptozotocin-induced diabetic mice.
Topics: Administration, Oral; Animals; Blood Glucose; Chlorella; Diabetes Mellitus, Experimental; Glucose To | 2005 |
Antihyperlipidemic effect of Eugenia jambolana seed kernel on streptozotocin-induced diabetes in rats.
Topics: Animals; Cholesterol; Diabetes Mellitus, Experimental; Fatty Acids; Fruit; Glyburide; Hypoglycemic A | 2005 |
Antihyperlipidemic and antiperoxidative effect of Diasulin, a polyherbal formulation in alloxan induced hyperglycemic rats.
Topics: Alloxan; Animals; Blood Glucose; Cholesterol; Diabetes Mellitus, Experimental; Dose-Response Relatio | 2005 |
Hypoglycemic effect of Malmea depressa root on streptozotocin diabetic rats.
Topics: Animals; Annonaceae; Blood Glucose; Chromatography, High Pressure Liquid; Diabetes Mellitus, Experim | 2005 |
Gliclazide attenuates the intracellular Ca2+ changes induced in vitro by ischemia in the retinal slices of rats with streptozotocin-induced diabetes.
Topics: Aniline Compounds; Animals; Calcium; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Gliclazi | 2005 |
Supplementation of fenugreek leaves reduces oxidative stress in streptozotocin-induced diabetic rats.
Topics: Animals; Antioxidants; Catalase; Diabetes Mellitus, Experimental; Dietary Supplements; Female; Gluta | 2005 |
Antiperoxidative and antioxidant effects of Casearia esculenta root extract in streptozotocin-induced diabetic rats.
Topics: Animals; Casearia; Diabetes Mellitus, Experimental; Glyburide; Hypoglycemic Agents; Kidney; Lipid Pe | 2005 |
Action of Hygrophila auriculata against streptozotocin-induced oxidative stress.
Topics: Acanthaceae; Animals; Antioxidants; Blood Glucose; Catalase; Diabetes Mellitus, Experimental; Dose-R | 2006 |
Mineral contents of aloe vera leaf gel and their role on streptozotocin-induced diabetic rats.
Topics: Aloe; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Glyburide; Hypoglycemic | 2005 |
Effect of glibenclamide on N-nitroso-N-methylurea-induced mammary tumors in diabetic and nondiabetic rats.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blood Glucose; Diabetes Mellitus | 2005 |
Inhibition of protein tyrosin phosphatase improves vascular endothelial dysfunction.
Topics: Animals; Aorta, Thoracic; Diabetes Mellitus, Experimental; Endothelium, Vascular; Enzyme Inhibitors; | 2006 |
Effect of chromium picolinate on modified forced swimming test in diabetic rats: involvement of serotonergic pathways and potassium channels.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Blood Glucose; Diabetes Mellitus, Experimental; Fe | 2006 |
Beneficial effects of aloe vera leaf gel extract on lipid profile status in rats with streptozotocin diabetes.
Topics: Aloe; Animals; Blood Glucose; Cholesterol; Diabetes Mellitus, Experimental; Fatty Acids; Fatty Acids | 2006 |
Anti-diabetic activity of SMK001, a poly herbal formula in streptozotocin induced diabetic rats: therapeutic study.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Dose-Response Relationship, Dr | 2006 |
The effect of Aegle marmelos fruit extract in streptozotocin diabetes: a histopathological study.
Topics: Administration, Oral; Aegle; Animals; Antioxidants; Blood Glucose; Catalase; Diabetes Mellitus, Expe | 2005 |
Antihyperlipidemic effect of Scoparia dulcis (sweet broomweed) in streptozotocin diabetic rats.
Topics: Animals; Blood Glucose; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Cholesterol, VLDL; Diabetes | 2006 |
Antihyperglycemic activity of Piper betle leaf on streptozotocin-induced diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diet; Fructose-Bisphosphatase; | 2006 |
Antidiabetic and renoprotective effects of the chloroform extract of Terminalia chebula Retz. seeds in streptozotocin-induced diabetic rats.
Topics: Animals; Blood Glucose; Chloroform; Diabetes Mellitus, Experimental; Disease Models, Animal; Dose-Re | 2006 |
Studies on hypoglycaemic activity of Solanum xanthocarpum Schrad. & Wendl. fruit extract in rats.
Topics: Alloxan; Animals; Blood Glucose; Cholesterol, VLDL; Diabetes Mellitus, Experimental; Diaphragm; Fatt | 2006 |
Possible antidiabetic and antihyperlipidaemic effect of fermented Parkia biglobosa (JACQ) extract in alloxan-induced diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Diabetes Melli | 2006 |
Acute effect of Trema micrantha (Ulmaceae) on serum glucose levels in normal and diabetic rats.
Topics: Animals; Blood Glucose; Brazil; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; G | 2006 |
Imaging docking and fusion of insulin granules induced by antidiabetes agents: sulfonylurea and glinide drugs preferentially mediate the fusion of newcomer, but not previously docked, insulin granules.
Topics: Animals; ATP-Binding Cassette Transporters; Diabetes Mellitus, Experimental; Glyburide; Hypoglycemic | 2006 |
Anti-diabetic effect of Murraya koenigii leaves on streptozotocin induced diabetic rats.
Topics: Animals; Blood Glucose; Blood Proteins; Blood Urea Nitrogen; Body Weight; Creatinine; Diabetes Melli | 2006 |
Antidiabetic effect of garlic (Allium sativum L.) in normal and streptozotocin-induced diabetic rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Blood Glucose; Cholesterol; Creatinine; | 2006 |
Beneficial effects of Murraya koenigii leaves on antioxidant defense system and ultra structural changes of pancreatic beta-cells in experimental diabetes in rats.
Topics: Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Enzymes; Glutathione; Glyburi | 2007 |
Antihyperglycemic effect of umbelliferone in streptozotocin-diabetic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Fructose-Bisphosphatase; Glucokinase; Gluco | 2006 |
The effect of the sulfonylurea glyburide on glutathione-S-transferase and glucose-6-phosphate dehydrogenase in streptozotocin-induced diabetic rat liver.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucosephosphate Dehydrogenase; Glutathione | 2006 |
Antihyperglycemic effects of Platycodon grandiflorum (Jacq.) A. DC. extract on streptozotocin-induced diabetic mice.
Topics: Animals; Area Under Curve; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Glucose Tole | 2007 |
Antihyperglycemic activity of Prunella vulgaris L. in streptozotocin-induced diabetic mice.
Topics: Animals; Area Under Curve; Blood Glucose; Diabetes Mellitus, Experimental; Dose-Response Relationshi | 2007 |
Hypoglycemic effect of Tournefortia hirsutissima L., on n-streptozotocin diabetic rats.
Topics: Administration, Oral; Animals; Animals, Newborn; Blood Glucose; Boraginaceae; Diabetes Mellitus, Exp | 2007 |
Effect of aloe vera leaf gel extract on membrane bound phosphatases and lysosomal hydrolases in rats with streptozotocin diabetes.
Topics: Adenosine Triphosphatases; Aloe; Animals; Blood Glucose; Cell Membrane; Diabetes Mellitus, Experimen | 2007 |
Gluconeogenic substrates and hepatic gluconeogenic enzymes in streptozotocin-diabetic rats: effect of mulberry (Morus indica L.) leaves.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diet; Gluconeogenesis; Glyburide; Hypoglyce | 2007 |
Can nitric oxide-generating compounds improve the oxidative stress response in experimentally diabetic rats?
Topics: Animals; Antioxidants; Arginine; Blood Glucose; Catalase; Diabetes Mellitus, Experimental; Glutathio | 2007 |
Time-dependent alteration in cromakalim-induced relaxation of corpus cavernosum from streptozocin-induced diabetic rats.
Topics: Animals; Cromakalim; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Glyburide; I | 2007 |
Preliminary studies on antihyperglycemic effect of aqueous extract of Brassica nigra (L.) Koch in streptozotocin induced diabetic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glyburide; Hyperglycemia; Hypoglycemic Agen | 2007 |
Hypoglycemic and hypolipidemic effects of alcoholic extract of Tribulus alatus in streptozotocin-induced diabetic rats: a comparative study with T. terrestris (Caltrop).
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glyburide; Hypoglycemic Agents; Hypolipidem | 2007 |
Comparison between ethanolic and aqueous extracts from Chinese juniper berries for hypoglycaemic and hypolipidemic effects in alloxan-induced diabetic rats.
Topics: Administration, Oral; Alloxan; Animals; Blood Glucose; Cholesterol; Diabetes Mellitus, Experimental; | 2008 |
Vasodilator effects of adenosine on retinal arterioles in streptozotocin-induced diabetic rats.
Topics: Acetylcholine; Adenosine; Animals; Arterioles; Blood Pressure; Diabetes Mellitus, Experimental; Enzy | 2008 |
Synthesis, characterization and hypoglycemic activity of Zn(II), Cd(II) and Hg(II) complexes with glibenclamide.
Topics: Animals; Anti-Bacterial Agents; Blood Glucose; Cadmium; Diabetes Mellitus, Experimental; Glyburide; | 2008 |
Insulin exocytosis in Goto-Kakizaki rat beta-cells subjected to long-term glinide or sulfonylurea treatment.
Topics: Animals; Blood Glucose; Cyclohexanes; Diabetes Mellitus, Experimental; Exocytosis; Glyburide; Hypogl | 2008 |
Antidiabetic and toxicological evaluations of naringenin in normoglycaemic and NIDDM rat models and its implications on extra-pancreatic glucose regulation.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Flavanones; Gluc | 2008 |
Antidiabetic properties of aqueous barks extract of Parinari excelsa in alloxan-induced diabetic rats.
Topics: Alloxan; Animals; Chrysobalanaceae; Diabetes Mellitus, Experimental; Dose-Response Relationship, Dru | 2008 |
Antidiabetic effect of alcoholic extract of Caralluma sinaica L. on streptozotocin-induced diabetic rabbits.
Topics: Animals; Apocynaceae; Body Weight; Diabetes Mellitus, Experimental; Glucose Tolerance Test; Glyburid | 2008 |
Antihyperglycaemic potential of the water-ethanol extract of Kalanchoe crenata (Crassulaceae).
Topics: Administration, Oral; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Ty | 2008 |
Anti-diabetic, anti-hyperlipidemic and spermatogenic effects of Amaranthus spinosus Linn. on streptozotocin-induced diabetic rats.
Topics: Amaranthus; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dose-Response Relationship, Dru | 2008 |
Antihyperglycemic and antilipidperoxidative effects of dry matter of culture broth of Inonotus obliquus in submerged culture on normal and alloxan-diabetes mice.
Topics: Alloxan; Animals; Antioxidants; Basidiomycota; Blood Glucose; Culture Media; Diabetes Mellitus, Expe | 2008 |
Effects of 18alpha-glycyrrhizin on the pharmacodynamics and pharmacokinetics of glibenclamide in alloxan-induced diabetic rats.
Topics: Animals; Cytochrome P-450 CYP3A; Diabetes Mellitus, Experimental; Drug Interactions; Glyburide; Glyc | 2008 |
Modulation by IBMX, fasting and experimental diabetes of glibenclamide-induced islet hormone release from the perfused rat pancreas.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Diabetes Mellitus, Experimental; Dose-Response Relationship, D | 1983 |
Cholinergic mechanisms in intestinal phase insulin secretion in rats.
Topics: Acetylcholine; Animals; Atropine; Blood Glucose; Diabetes Mellitus, Experimental; Gastric Inhibitory | 1983 |
[Hypoglycemic effects of the blended Chinese traditional medicines in genetically and chemically diabetic mice].
Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glyburide; Hypoglycemic Agents; Ma | 1984 |
Dithisone diabetes in rabbits and its prevention by sulfhydryl and imidazole containing compounds.
Topics: Animals; Animals, Newborn; Diabetes Mellitus, Experimental; Dithizone; Female; Glyburide; Imidazoles | 1984 |
[The effect of the treatment of diabetes mellitus on the development of cardiac changes in alloxan diabetes].
Topics: Alloxan; Animals; Blood Glucose; Carbutamide; Diabetes Mellitus, Experimental; Dogs; Glyburide; Hypo | 1980 |
Studies on the biochemical effects of glibenclamide on alloxan diabetic rabbits.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Glyburide; Glycosuria; Lipid M | 1980 |
Serum glycohydrolases in compensated & decompensated alloxan diabetic rabbits.
Topics: Animals; Diabetes Mellitus, Experimental; Glyburide; Glycoside Hydrolases; Insulin; Kinetics; Male; | 1981 |
Plasma high density lipoprotein cholesterol in streptozotocin diabetic and non-diabetic mice after prolonged administration of glibenclamide, chlorpropamide and metformin.
Topics: Animals; Blood Glucose; Body Weight; Chlorpropamide; Cholesterol; Cholesterol, HDL; Diabetes Mellitu | 1981 |
Effects of bittergourd (Momordica charantia) seed & glibenclamide in streptozotocin induced diabetes mellitus.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glyburide; Glycogen; Male; Plants, Medicina | 1982 |
Anti-diabetic effects of onion and garlic sulfoxide amino acids in rats.
Topics: Allium; Animals; Blood Glucose; Cysteine; Diabetes Mellitus, Experimental; Garlic; Glyburide; Hypogl | 1995 |
Antidiabetic effects of S-methylcysteine sulphoxide on alloxan diabetes.
Topics: Allium; Alloxan; Animals; Blood Glucose; Cysteine; Diabetes Mellitus, Experimental; Glyburide; Insul | 1995 |
Drug-induced endothelium-dependent and -independent relaxations in isolated resistance vessels taken from simultaneously hypertensive and streptozotocin-diabetic rats.
Topics: Animals; Benzopyrans; Bradykinin; Calcium; Cromakalim; Diabetes Mellitus, Experimental; Endothelium, | 1994 |
Stimulation of insulin secretion and potentiation of glibenclamide-induced insulin release by the dimethyl ester of glutamic acid in anaesthetized rats.
Topics: Anesthesia, General; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Drug Synergism; Female | 1995 |
Hypoglycemic effects of leucodelphinidin derivative isolated from Ficus bengalensis (Linn).
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Flavonoids; Glucose Tolerance Test; Glyburi | 1994 |
Impaired in vivo insulin secretion in response to non-glucidic secretagogues in adult rats after neonatal streptozotocin.
Topics: Animals; Animals, Newborn; Blood Glucose; Diabetes Mellitus, Experimental; Glucose; Glyburide; Insul | 1994 |
Effect of the sulfonylurea glyburide on glutathione and glutathione peroxidase activity in alloxan-induced diabetic rat hepatocytes.
Topics: Alloxan; Animals; Diabetes Mellitus, Experimental; Female; Glutathione; Glutathione Peroxidase; Glyb | 1994 |
Reduction in ATP-sensitive potassium channel-mediated antinociception in diabetic mice.
Topics: Adenosine Triphosphate; Analgesics; Animals; Benzopyrans; Blood Glucose; Cromakalim; Diabetes Mellit | 1994 |
Effect of the sulfonylurea glyburide on glycogen synthase activity in alloxan-induced diabetic rat adipocytes.
Topics: Adipose Tissue; Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Female; Glyburide; | 1994 |
Effect of the sulfonylurea glyburide on glycogen synthesis in alloxan-induced diabetic rat hepatocytes.
Topics: Animals; Body Weight; Diabetes Mellitus, Experimental; Female; Glyburide; Liver; Liver Glycogen; Rat | 1994 |
The effects of glyburide and insulin on the decreased beta-adrenergic responsiveness of the gastrointestinal tract in rats with non-insulin-dependent diabetes.
Topics: Albuterol; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diges | 1994 |
Studies on the glycemic and lipidemic effect of atenolol and propranolol in normal and diabetic rats.
Topics: Animals; Atenolol; Blood Glucose; Cholesterol; Diabetes Mellitus, Experimental; Glyburide; Insulin; | 1994 |
Effect of the sulfonylurea glyburide on superoxide dismutase activity in alloxan-induced diabetic rat hepatocytes.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Fem | 1994 |
Potentiating effects of combined usage of three sulfonylurea drugs on the occurrence of alloxan diabetes in rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Drug Combinations; Drug Synergism; Gliclazi | 1993 |
The effects of glyburide and insulin on the cardiac performance in rats with non-insulin-dependent diabetes mellitus.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dri | 1993 |
Unique natriuretic properties of the ATP-sensitive K(+)-channel blocker glyburide in conscious rats.
Topics: Adenosine Triphosphate; Animals; Diabetes Mellitus, Experimental; Female; Glyburide; Hemodynamics; K | 1993 |
Diabetes and ATP-sensitive potassium channel openers and blockers in isolated ischemic/reperfused hearts.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzopyrans; Cations; | 1995 |
Antiperoxide effect of S-allyl cysteine sulfoxide, an insulin secretagogue, in diabetic rats.
Topics: Animals; Blood Glucose; Catalase; Cysteine; Diabetes Mellitus, Experimental; Garlic; Glucose; Glybur | 1996 |
Effects of luteolin 5-O-beta-rutinoside in streptozotocin-induced diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Flavonoids; Glyburide; Hypogly | 1996 |
Studies on pyrazinoylguanidine. 2. Comparative drug and dose effects on glucose and lipid metabolism in streptozotocin-induced diabetic rats.
Topics: Analysis of Variance; Animals; Anti-Bacterial Agents; Blood Glucose; Diabetes Mellitus, Experimental | 1996 |
Effects of cromakalim and glibenclamide in ischemic and reperfused hearts.
Topics: Animals; Anti-Arrhythmia Agents; Benzopyrans; Cromakalim; Diabetes Mellitus, Experimental; Glyburide | 1996 |
Cardiovascular effects of conventional sulfonylureas and glimepiride.
Topics: Animals; Blood Pressure; Cardiovascular System; Coronary Vessels; Diabetes Mellitus, Experimental; D | 1996 |
Impairment of endothelium-dependent relaxation of the isolated basilar artery from streptozotocin-induced diabetic rats.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Animals; Basilar Artery; Diabetes Mellitus, Experimental | 1996 |
Interaction of a herbomineral preparation D-400, with oral hypoglycaemic drugs.
Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Drug Interactions; Glyburide; Hypo | 1996 |
Evaluation of BTS 67 582, a novel antidiabetic agent, in normal and diabetic rats.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Blood Glucose; Brain; Cromakalim; Diabetes Mellitus, Experime | 1997 |
Effect of a new hypoglycemic agent, A-4166 [(-)-N-(trans-4-isopropylcyclohexanecarbonyl)-D-phenylalanine], on postprandial blood glucose excursion: comparison with voglibose and glibenclamide.
Topics: Animals; Blood Glucose; Cyclohexanes; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Glucose; G | 1997 |
Effect of the sulfonylurea glyburide on superoxide dismutase in streptozotocin-induced diabetic rat muscle.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Gly | 1997 |
Acceleration of stiffness in underperfused diabetic rat hearts by glyburide, a KATP channel blocker, and its prevention by levcromakalim and insulin.
Topics: Animals; Anti-Arrhythmia Agents; Coronary Circulation; Cromakalim; Diabetes Mellitus, Experimental; | 1997 |
The effect on plasma glucose, insulin and glucagon levels of treatment of diabetic rats with the medicinal plant Rhazya stricta and with glibenclamide, alone and in combination.
Topics: Animals; Blood Glucose; Cholesterol; Diabetes Mellitus, Experimental; Dose-Response Relationship, Dr | 1997 |
Hypoglycemic effect of trans-dehydrocrotonin, a nor-clerodane diterpene from Croton cajucara.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diterpenes; Diterpenes, Clerodane; Glucose; | 1997 |
Microvascular permeability with sulfonylureas in normal and diabetic hamsters.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Capillary Permeability; Cricetinae; Dextrans; D | 1997 |
Effect of antidiabetic agents on the increase in glycemia and insulinemia caused by refeeding in hereditarily diabetic rats.
Topics: Animals; Blood Glucose; Carbamates; Diabetes Mellitus, Experimental; Food; Glyburide; Hypoglycemic A | 1997 |
An investigation into the effect of sulfonylurea glyburide on glutathione peroxidase activity in streptozotocin-induced diabetic rat muscle tissue.
Topics: Animals; Diabetes Mellitus, Experimental; Glutathione Peroxidase; Glyburide; Hypoglycemic Agents; Ma | 1998 |
The effect of the sulfonylurea glyburide on nitric oxide in streptozotocin-induced diabetic rat.
Topics: Animals; Diabetes Mellitus, Experimental; Glyburide; Hypoglycemic Agents; Male; Nitric Oxide; Rats | 1998 |
Effect of streptozotocin-induced diabetes on rat brain sulfonylurea binding sites.
Topics: Amygdala; Animals; Binding Sites; Blood Glucose; Body Weight; Brain Chemistry; Diabetes Mellitus, Ex | 1998 |
Effect of diazoxide, an ATP-dependent potassium-channel opener, on isolated aortae of normal and diabetic rats.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Diabetes Mellitus, Experimental; Diazoxide; Glybu | 1998 |
JTT-608 controls blood glucose by enhancement of glucose-stimulated insulin secretion in normal and diabetes mellitus rats.
Topics: Administration, Oral; Animals; Animals, Newborn; Blood Glucose; Butyrates; Cyclohexanes; Diabetes Me | 1999 |
The in vivo interaction between gliclazide and glibenclamide and insulin on glucose disposal in the rat.
Topics: Animals; Biomarkers; Blood Glucose; Diabetes Mellitus, Experimental; Drug Interactions; Fatty Acids, | 1999 |
Lung local defense in experimental diabetes mellitus and the effect of 11,20-dihydroxyecdysone in combination with maninil.
Topics: Animals; Diabetes Mellitus, Experimental; Ecdysterone; Glyburide; Hypoglycemic Agents; Lung; Molecul | 1999 |
Antioxidant status in experimental type 2 diabetes mellitus: effects of glibenclamide and glipizide on various rat tissues.
Topics: Animals; Antioxidants; Brain; Catalase; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; | 1999 |
Hypoglycaemic effect of Musa sapientum L. in alloxan-induced diabetic rats.
Topics: Animals; Blood Glucose; Chloroform; Diabetes Mellitus, Experimental; Dose-Response Relationship, Dru | 1999 |
Hypoglycaemic action of the flavonoid fraction of Cuminum nigrum seeds.
Topics: Administration, Oral; Alloxan; Animals; Apiaceae; Blood Glucose; Diabetes Mellitus, Experimental; Do | 2000 |
Cardiomyopathic changes in streptozotocin-induced diabetes.
Topics: Adenosine Triphosphatases; Animals; Body Weight; Calcium Channel Blockers; Cardiomyopathies; Cardiot | 1999 |
Exaggerated impact of ATP-sensitive K(+) channels on afferent arteriolar diameter in diabetes mellitus.
Topics: Adenosine Triphosphate; Animals; Arterioles; Benzopyrans; Cyclopentanes; Diabetes Mellitus, Experime | 2000 |
Uptake of tritiated glibenclamide by endocrine and exocrine pancreas.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Female; Glyburide; Insulin; Is | 2000 |
Hypoglycemic effect of Equisetum myriochaetum aerial parts on streptozotocin diabetic rats.
Topics: Animals; Blood Glucose; Chromatography, High Pressure Liquid; Diabetes Mellitus, Experimental; Flavo | 2000 |
Uptake of tritiated glibenclamide by endocrine and exocrine pancreas.
Topics: Animals; Diabetes Mellitus, Experimental; Erythrocytes; Female; Glucose; Glyburide; Hypoglycemic Age | 2000 |
Effect of oral administration of bark extracts of Pterocarpus santalinus L. on blood glucose level in experimental animals.
Topics: Administration, Oral; Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dose-Respons | 2001 |
Hypoglycemic and antihyperglycemic activity of Syzygium alternifolium (Wt.) Walp. seed extracts in normal and diabetic rats.
Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; | 2001 |
Changes in electrical properties of detrusor smooth muscle in the STZ (streptozotocin)-diabetic rat.
Topics: Action Potentials; Animals; Anti-Bacterial Agents; Antihypertensive Agents; Diabetes Mellitus, Exper | 2001 |
Influence of ATP-sensitive K+ channel modulation on the mechanical properties of diabetic myocardium.
Topics: Adenosine Triphosphate; Animals; Biomechanical Phenomena; Blood Glucose; Cromakalim; Depression, Che | 2001 |
Insulin secretion to glucose as well as nonglucose stimuli is impaired in spontaneously diabetic Nagoya-Shibata-Yasuda mice.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2001 |
[Effects of glibenclamide on mRNA level of ATP-sensitive potassium channels of heart in normal and streptozotocin-induced diabetic rats].
Topics: Adenosine Triphosphate; Animals; Diabetes Mellitus, Experimental; Gene Expression Regulation; Glybur | 2000 |
ATP-dependent K(+) channels contribute to local metabolic coronary vasodilation in experimental diabetes.
Topics: Animals; Blood Glucose; Coronary Vessels; Diabetes Mellitus, Experimental; Dogs; Female; Glyburide; | 2002 |
Diabetic glomerulosclerosis in KK mice and its prevention by glyburide and pyridinolcarbamate.
Topics: Animals; Blood Glucose; Carbamates; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Glucose | 1979 |
Serum mineral changes in alloxan diabetes before and after treatment with some hypoglycemic drugs.
Topics: Animals; Blood Glucose; Calcium; Copper; Diabetes Mellitus, Experimental; Glyburide; Hypoglycemic Ag | 1977 |
Serum enzyme changes in experimental diabetes before and after treatment with some hypoglycaemic drugs.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Ceruloplasmin; Dia | 1977 |
Effect of ICI 66082, a beta-adrenoceptor blocking drug on blood glucose in the rat.
Topics: Adipose Tissue; Animals; Atenolol; Blood Glucose; Diabetes Mellitus, Experimental; Glucose; Glyburid | 1975 |
Regulation of exocrine pancreatic secretory process by insulin in vivo.
Topics: Amylases; Animals; Blood Glucose; Carbachol; Chymotrypsinogen; Diabetes Mellitus, Experimental; Dose | 1975 |
[Hypoglycaemic activity of centaurea aspera L (author's transl)].
Topics: Administration, Oral; Animals; Diabetes Mellitus; Diabetes Mellitus, Experimental; Female; Glyburide | 1976 |
Antidiabetic effect of a glycoside of pelargonidin isolated from the bark of Ficus bengalensis Linn.
Topics: Animals; Anthocyanins; Blood Glucose; Diabetes Mellitus, Experimental; Flavonoids; Glyburide; Glycos | 1992 |
Antidiabetic effects of S-allyl cysteine sulphoxide isolated from garlic Allium sativum Linn.
Topics: Animals; Cysteine; Diabetes Mellitus, Experimental; Garlic; Glyburide; Insulin; Male; Plants, Medici | 1992 |
Effect of exercise training and chronic glyburide treatment on glucose homeostasis in diabetic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Fatty Acids, Nonesterified; Female; Glucose | 1992 |
Impaired glucose sensitivity of ATP-sensitive K+ channels in pancreatic beta-cells in streptozotocin-induced NIDDM rats.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Blood Glucose; Cells, Cultured; Diabetes Mellitus | 1992 |
Possibility of ideal blood glucose control by a new oral hypoglycemic agent, N-[(trans-4-isopropylcyclohexyl)-carbonyl]-D-phenylalanine (A-4166), and its stimulatory effect on insulin secretion in animals.
Topics: Animals; Blood Glucose; Cyclohexanes; Diabetes Mellitus, Experimental; Dogs; Glucose Tolerance Test; | 1991 |
[The effect of dopaminergic pharmacological agents on the pancreatic islet apparatus in rats].
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dopamine Agents; Drug Evaluation, Preclinic | 1990 |
The potentiating effect of the simultaneous administration of tolbutamide, glibenclamide, and gliclazide on the development of alloxan-induced diabetes in rats.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Drug Synergism; Gliclazide; Gl | 1990 |
Effect of aloes on blood glucose levels in normal and alloxan diabetic mice.
Topics: Administration, Oral; Aloe; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glyburide; Hypo | 1990 |
Characterization of potassium channels in pancreatic beta cells from ob/ob mice.
Topics: Animals; Cells, Cultured; Diabetes Mellitus, Experimental; Diazoxide; Electric Conductivity; Glucose | 1990 |
In vitro effects of sulfonylurea on glucose transport and translocation of glucose transporters in adipocytes from streptozocin-induced diabetic rats.
Topics: Adipose Tissue; Animals; Biological Transport, Active; Cell Membrane; Cells, Cultured; Cytochalasin | 1989 |
The effect of sulfonylurea therapy on defective calcium movement associated with diabetic cardiomyopathy.
Topics: Adenosine Triphosphate; Animals; Blood Glucose; Ca(2+) Mg(2+)-ATPase; Calcium; Calcium-Transporting | 1989 |
Potentiating effect of glibenclamide on the occurrence of streptozotocin diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Drug Synergism; Glyburide; Male; Rats; Rats, Inbred Strain | 1986 |
Kidney disease in KK mice: effect of glyburide.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Nephrop | 1988 |
[Study on biological characteristics of spontaneous diabetic KK mice].
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Female; Glucose Tolerance Test; Glyburide; | 1988 |
Cyclic AMP phosphodiesterase in diabetes. Effect of glyburide.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adipose Tissue; Animals; Blood Glucose; Diabetes Mellitus, Expe | 1986 |
Potentiating effect of glibenclamide on the occurrence of alloxan diabetes in rats.
Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Drug Synergism; Glyburide; Male; R | 1986 |
The antidiabetic activity of aloes: preliminary clinical and experimental observations.
Topics: Aloe; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glyburide; | 1986 |
The hypoglycemic sulfonylureas glyburide and tolbutamide inhibit fatty acid oxidation by inhibiting carnitine palmitoyltransferase.
Topics: Acyltransferases; Animals; Carnitine O-Palmitoyltransferase; Diabetes Mellitus, Experimental; Fatty | 1987 |
Sulfonylurea-induced inhibition of glucagon secretion from the perfused rat pancreas: evidence for a direct, non-paracrine effect.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucagon; Glyburide; In Vitro Techniques; M | 1986 |
Effects of glyburide in a rat model of reduced B-cell mass.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glyburide; Insulin; Insulin Secretion; Isle | 1988 |
Effect of chronic sulfonylurea treatment on the myocardium of insulin-dependent diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Glucose; Glucose Tolerance Test | 1988 |
Proceedings: The hypoglycaemic action of ICI 66082 (4-(2-hydroxy-3-isopropyl-aminopropoxy) phenyl acetamide) in the rat.
Topics: Acetamides; Adrenergic beta-Antagonists; Animals; Atenolol; Blood Glucose; Diabetes Mellitus, Experi | 1974 |
The effect of glibenclamide on non-esterified fatty acid levels in the plasma of the severely alloxan diabetic rat.
Topics: Animals; Blood Glucose; Chlorpropamide; Diabetes Mellitus, Experimental; Fatty Acids, Nonesterified; | 1973 |
The effect of glibenclamide on two enzymes important in gluconeogenesis.
Topics: Animals; Diabetes Mellitus, Experimental; Gluconeogenesis; Glucose-6-Phosphatase; Glyburide; In Vitr | 1973 |
The effect of glibenclamide on two enzymes important in gluconeogenesis.
Topics: Administration, Oral; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Gluconeogenesis; Gluc | 1974 |
Monoamines in the pancreatic islets of the mouse. 5-hydroxytryptamine as an intracellular modifier of insulin secretion, and the hypoglycaemic action of monoamine oxidase inhibitors.
Topics: 5-Hydroxytryptophan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Female; Glucose; Glybu | 1971 |