glyburide has been researched along with Aging in 24 studies
Glyburide: An antidiabetic sulfonylurea derivative with actions like those of chlorpropamide
glyburide : An N-sulfonylurea that is acetohexamide in which the acetyl group is replaced by a 2-(5-chloro-2-methoxybenzamido)ethyl group.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Aging appears to have no influence on the pharmacokinetics of glyburide." | 5.08 | Pharmacokinetics and pharmacodynamics of glyburide in young and elderly patients with non-insulin-dependent diabetes mellitus. ( Antal, EJ; Jaber, LA; Welshman, IR, 1996) |
| " Patients were randomly assigned to sulphonylurea increased up to its maximum dosage (1st group) or to addition of metformin (2nd group)." | 2.69 | Poorly controlled elderly Type 2 diabetic patients: the effects of increasing sulphonylurea dosages or adding metformin. ( Ambrosi, F; Carle, F; Filipponi, P; Gregorio, F; Manfrini, S; Merante, D; Testa, R; Velussi, M, 1999) |
| "Glyburide did not lower DPP-IV activity or glycosylated hemoglobin." | 1.32 | Reduced serum dipeptidyl peptidase-IV after metformin and pioglitazone treatments. ( Croom, DK; Lenhard, JM; Minnick, DT, 2004) |
| " In the beta cell of aged rats, the following abnormalities were found: (a) right shift of the dose-response curve (depressed sensitivity) of glucose-induced insulin release, (b) no increase of the maximum response to glucose in the face of increased insulin content of the islets (reduced responsiveness), (c) no response to forskolin and normal response to the phorbol ester and glyburide, and (d) increased sensitivity to nifedipine." | 1.29 | Insulin secretion by the pancreatic beta cell of aged rats. ( Aizawa, T; Hashizume, K; Ishihara, F; Komatsu, M; Nishii, N; Sato, Y; Suzuki, N; Yamada, T, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (12.50) | 18.7374 |
| 1990's | 13 (54.17) | 18.2507 |
| 2000's | 6 (25.00) | 29.6817 |
| 2010's | 2 (8.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Simard, JM | 1 |
| Popovich, PG | 1 |
| Tsymbalyuk, O | 1 |
| Caridi, J | 1 |
| Gullapalli, RP | 1 |
| Kilbourne, MJ | 1 |
| Gerzanich, V | 1 |
| Raveaud, S | 1 |
| Verdetti, J | 1 |
| Faury, G | 1 |
| Samora, JB | 1 |
| Goodwill, AG | 1 |
| Frisbee, JC | 1 |
| Boegehold, MA | 1 |
| Lenhard, JM | 1 |
| Croom, DK | 1 |
| Minnick, DT | 1 |
| Shinmura, K | 1 |
| Tamaki, K | 1 |
| Bolli, R | 1 |
| Sakamoto, K | 1 |
| Yonoki, Y | 1 |
| Fujioka, T | 1 |
| Matsumura, M | 1 |
| Mitsuta, Y | 1 |
| Sano, M | 1 |
| Saito, M | 1 |
| Nakahara, T | 1 |
| Ishii, K | 1 |
| Tattersall, RB | 1 |
| Bangalore, R | 1 |
| Triggle, DJ | 1 |
| Wong, J | 1 |
| Vanderford, PA | 1 |
| Fineman, JR | 1 |
| Soifer, SJ | 1 |
| Aizawa, T | 1 |
| Komatsu, M | 1 |
| Sato, Y | 1 |
| Ishihara, F | 1 |
| Suzuki, N | 1 |
| Nishii, N | 1 |
| Hashizume, K | 1 |
| Yamada, T | 1 |
| Tricarico, D | 2 |
| Camerino, DC | 1 |
| Guiot, Y | 1 |
| Henquin, JC | 1 |
| Rahier, J | 1 |
| Jaber, LA | 1 |
| Antal, EJ | 1 |
| Welshman, IR | 1 |
| Petruzzi, R | 1 |
| Conte Camerino, DC | 1 |
| Xie, LH | 1 |
| Takano, M | 1 |
| Noma, A | 1 |
| Evans, AM | 1 |
| Osipenko, ON | 1 |
| Haworth, SG | 1 |
| Gurney, AM | 1 |
| Ferrer, M | 1 |
| Tejera, N | 1 |
| Marín, J | 1 |
| Balfagón, G | 1 |
| Gregorio, F | 1 |
| Ambrosi, F | 1 |
| Manfrini, S | 1 |
| Velussi, M | 1 |
| Carle, F | 1 |
| Testa, R | 1 |
| Merante, D | 1 |
| Filipponi, P | 1 |
| Chiou, LC | 1 |
| How, CH | 1 |
| Lee, TM | 1 |
| Su, SF | 1 |
| Chou, TF | 1 |
| Lee, YT | 1 |
| Tsai, CH | 1 |
| Xia, Y | 1 |
| Haddad, GG | 1 |
| Miller, JA | 1 |
| Velayo, NL | 1 |
| Dage, RC | 1 |
| Rampe, D | 1 |
| Draznin, B | 2 |
| Steinberg, JP | 1 |
| Leitner, JW | 1 |
| Sussman, KE | 2 |
| Kao, M | 1 |
| Sherman, N | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy and Safety of Metformin Glycinate Compared to Metformin Hydrochloride on the Progression of Type 2 Diabetes[NCT04943692] | Phase 3 | 500 participants (Anticipated) | Interventional | 2021-08-31 | Suspended (stopped due to Administrative decision of the investigation direction) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for glyburide and Aging
| Article | Year |
|---|---|
[25 years of diabetic treatment by oral hypoglycemic agents: successes and failures].
Topics: Aged; Aging; Blood Glucose; Cardiovascular Diseases; Chlorpropamide; Diabetes Complications; Diabete | 1984 |
3 trials available for glyburide and Aging
| Article | Year |
|---|---|
Pharmacokinetics and pharmacodynamics of glyburide in young and elderly patients with non-insulin-dependent diabetes mellitus.
Topics: Adult; Aged; Aging; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 2; Female; Glucose Tolerance T | 1996 |
Poorly controlled elderly Type 2 diabetic patients: the effects of increasing sulphonylurea dosages or adding metformin.
Topics: Aged; Aging; Antithrombin III; Blood Glucose; Blood Platelets; Cholesterol, HDL; Cholesterol, LDL; D | 1999 |
Loss of preconditioning by attenuated activation of myocardial ATP-sensitive potassium channels in elderly patients undergoing coronary angioplasty.
Topics: Adult; Aged; Aging; Angioplasty, Balloon, Coronary; ATP-Binding Cassette Transporters; Chest Pain; C | 2002 |
20 other studies available for glyburide and Aging
| Article | Year |
|---|---|
MRI evidence that glibenclamide reduces acute lesion expansion in a rat model of spinal cord injury.
Topics: Aging; Animals; Disease Models, Animal; Female; Glyburide; Hemorrhage; Magnetic Resonance Imaging; R | 2013 |
Nicorandil protects ATP-sensitive potassium channels against oxidation-induced dysfunction in cardiomyocytes of aging rats.
Topics: Adenosine Triphosphate; Aging; Animals; Animals, Newborn; Anti-Arrhythmia Agents; Dinitrobenzenes; F | 2009 |
Growth-dependent changes in the contribution of carbon monoxide to arteriolar function.
Topics: Acetylcholine; Age Factors; Aging; Aminolevulinic Acid; Animals; Animals, Newborn; Arterioles; Carbo | 2010 |
Reduced serum dipeptidyl peptidase-IV after metformin and pioglitazone treatments.
Topics: Aging; Animals; Blood Glucose; Cell Membrane; Dipeptidyl Peptidase 4; Glucagon; Glucagon-Like Peptid | 2004 |
Short-term caloric restriction improves ischemic tolerance independent of opening of ATP-sensitive K+ channels in both young and aged hearts.
Topics: Adenosine Triphosphate; Aging; AMP-Activated Protein Kinases; Animals; Body Weight; Caloric Restrict | 2005 |
Disappearance of glibenclamide-induced hypoglycemia in Wistar-Kyoto rats.
Topics: Aging; Animals; Blood Glucose; Blood Pressure; Glucose Oxidase; Glyburide; Hypoglycemia; Hypoglycemi | 2006 |
Age-dependent changes in voltage-gated calcium channels and ATP-dependent potassium channels in Fischer 344 rats.
Topics: Adenosine Triphosphate; Aging; Animals; Brain; Calcium; Calcium Channels; Glyburide; Heart Rate; Hip | 1995 |
Developmental effects of endothelin-1 on the pulmonary circulation in sheep.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Aging; Animals; Arginine; Endoth | 1994 |
Insulin secretion by the pancreatic beta cell of aged rats.
Topics: Aging; Animals; Colforsin; Dose-Response Relationship, Drug; Glucose; Glyburide; In Vitro Techniques | 1994 |
ATP-sensitive K+ channels of skeletal muscle fibers from young adult and aged rats: possible involvement of thiol-dependent redox mechanisms in the age-related modifications of their biophysical and pharmacological properties.
Topics: Acetylcysteine; Adenosine Triphosphate; Aging; Animals; Cysteine; Glyburide; In Vitro Techniques; Ma | 1994 |
Effects of glibenclamide on pancreatic beta-cell proliferation in vivo.
Topics: Aging; Animals; Bromodeoxyuridine; Cell Division; Cell Nucleus; Cell Size; Female; Glyburide; Immuno | 1994 |
Different sulfonylurea and ATP sensitivity characterizes the juvenile and the adult form of KATP channel complex of rat skeletal muscle.
Topics: Adenosine Triphosphate; Aging; Animals; Animals, Newborn; Glyburide; Male; Muscle Fibers, Skeletal; | 1997 |
Development of inwardly rectifying K+ channel family in rat ventricular myocytes.
Topics: Adenosine Triphosphate; Aging; Animals; Animals, Newborn; Barium Compounds; Cation Transport Protein | 1997 |
Resting potentials and potassium currents during development of pulmonary artery smooth muscle cells.
Topics: Aging; Animals; Animals, Newborn; Calcium; Electric Conductivity; Glyburide; Hypoxia; Membrane Poten | 1998 |
Effect of age on the vasorelaxation elicited by cromakalim. Role of K+ channels and cyclic GMP.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Aging; Animals; Aorta, Thoracic; Cromakalim; Cyclic GMP; End | 1998 |
ATP-sensitive K+ channels and cellular actions of morphine in periaqueductal gray slices of neonatal and adult rats.
Topics: Adenosine Triphosphate; Aging; Animals; Animals, Newborn; ATP-Binding Cassette Transporters; Electro | 2001 |
Major differences in CNS sulfonylurea receptor distribution between the rat (newborn, adult) and turtle.
Topics: Aging; Animals; Animals, Newborn; ATP-Binding Cassette Transporters; Autoradiography; Brain; Glyburi | 1991 |
High affinity [3H]glibenclamide binding sites in rat neuronal and cardiac tissue: localization and developmental characteristics.
Topics: Aging; Animals; Autoradiography; Binding Sites; Brain; Female; Glyburide; Heart; Male; Membranes; My | 1991 |
The nature of insulin secretory defect in aging rats.
Topics: 1-Methyl-3-isobutylxanthine; Aging; Animals; Exocytosis; Glucose; Glyburide; Glyceraldehyde; Insulin | 1985 |
Relationship between cytosolic free calcium concentration and 2-deoxyglucose uptake in adipocytes isolated from 2- and 12-month-old rats.
Topics: Adipose Tissue; Aging; Animals; Calcium; Cytosol; Deoxy Sugars; Deoxyglucose; Glyburide; Insulin; Io | 1988 |