glutaric acid has been researched along with Leigh Disease in 3 studies
glutaric acid: RN given refers to parent cpd
glutaric acid : An alpha,omega-dicarboxylic acid that is a linear five-carbon dicarboxylic acid.
Leigh Disease: A group of metabolic disorders primarily of infancy characterized by the subacute onset of psychomotor retardation, hypotonia, ataxia, weakness, vision loss, eye movement abnormalities, seizures, dysphagia, and lactic acidosis. Pathological features include spongy degeneration of the neuropile of the basal ganglia, thalamus, brain stem, and spinal cord. Patterns of inheritance include X-linked recessive, autosomal recessive, and mitochondrial. Leigh disease has been associated with mutations in genes for the PYRUVATE DEHYDROGENASE COMPLEX; CYTOCHROME-C OXIDASE; ATP synthase subunit 6; and subunits of mitochondrial complex I. (From Menkes, Textbook of Child Neurology, 5th ed, p850).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The cohort included patients with Leigh and Leigh-like syndrome (n = 25), other mitochondrial diseases (n = 25), Wilson disease (n = 40), Type 1 glutaric aciduria (n = 14), maple syrup urine disease (n = 13), giant axonal neuropathy (n = 5) and L-2 hydroxy glutaric aciduria (n = 3)." | 3.80 | Bilateral hypertrophic olivary nucleus degeneration on magnetic resonance imaging in children with Leigh and Leigh-like syndrome. ( Arvinda, HR; Bharath, MM; Bindu, PS; Gayathri, N; Govindaraju, C; Khan, NA; Nagappa, M; Ranjith, D; Sinha, S; Sonam, K; Taly, AB; Thangaraj, K, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (66.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bindu, PS | 1 |
| Taly, AB | 1 |
| Sonam, K | 1 |
| Govindaraju, C | 1 |
| Arvinda, HR | 1 |
| Gayathri, N | 1 |
| Bharath, MM | 1 |
| Ranjith, D | 1 |
| Nagappa, M | 1 |
| Sinha, S | 1 |
| Khan, NA | 1 |
| Thangaraj, K | 1 |
| Rutledge, JN | 1 |
| Hilal, SK | 1 |
| Silver, AJ | 1 |
| Defendini, R | 1 |
| Fahn, S | 1 |
| Stutchfield, P | 1 |
| Edwards, MA | 1 |
| Gray, RG | 1 |
| Crawley, P | 1 |
| Green, A | 1 |
3 other studies available for glutaric acid and Leigh Disease
| Article | Year |
|---|---|
Bilateral hypertrophic olivary nucleus degeneration on magnetic resonance imaging in children with Leigh and Leigh-like syndrome.
Topics: Child; Cohort Studies; Diagnosis, Differential; Early Diagnosis; Female; Giant Axonal Neuropathy; Gl | 2014 |
Magnetic resonance imaging of dystonic states.
Topics: Adolescent; Adult; Brain; Child; Child, Preschool; Dystonia; Ferric Compounds; Glutarates; Humans; I | 1988 |
Glutaric aciduria type I misdiagnosed as Leigh's encephalopathy and cerebral palsy.
Topics: Amino Acid Metabolism, Inborn Errors; Brain Diseases, Metabolic; Cerebral Palsy; Child; Child, Presc | 1985 |