glutaral and Heart Valve Diseases studies

Glutaral: One of the protein CROSS-LINKING REAGENTS that is used as a disinfectant for sterilization of heat-sensitive equipment and as a laboratory reagent, especially as a fixative.
glutaraldehyde : A dialdehyde comprised of pentane with aldehyde functions at C-1 and C-5.

Heart Valve Diseases: Pathological conditions involving any of the various HEART VALVES and the associated structures (PAPILLARY MUSCLES and CHORDAE TENDINEAE).

Research Excerpts

Excerpt	Relevance	Reference
"Glutaraldehyde was safely used in a surgical intervention for AAIE in the mitral position with acceptable early and mid-term results."	5.48	Safe Use of Glutaraldehyde to Repair the Destroyed Valve in Active Infective Mitral Valve Endocarditis. ( Abe, T; Bando, K; Hashimoto, K; Kinouchi, K; Matsumura, Y; Nakamura, K; Sakamoto, Y; Yoshitake, M, 2018)
"Glutaraldehyde was safely used in a surgical intervention for AAIE in the mitral position with acceptable early and mid-term results."	1.48	Safe Use of Glutaraldehyde to Repair the Destroyed Valve in Active Infective Mitral Valve Endocarditis. ( Abe, T; Bando, K; Hashimoto, K; Kinouchi, K; Matsumura, Y; Nakamura, K; Sakamoto, Y; Yoshitake, M, 2018)
"Glutaraldehyde-treated bioprosthetic heart valves are commonly used for replacement of diseased heart valves."	1.37	Degenerative processes in bioprosthetic mitral valves in juvenile pigs. ( Funder, JA; Hasenkam, JM; Honge, JL; Kronborg, MB; Pedersen, TB, 2011)
"Glutaraldehyde treatment of the anterior leaflet caused thickening of the cusp and chordae associated with partial devitalization of its core tissue, partial loss of endothelium and intense fibrocellular reaction with abundant elastic fibers without altering its functional integrity."	1.29	In situ mitral valve stabilization with glutaraldehyde. ( Ali, ML; Becker, A; Duran, CM; Kumar, SP; Prabhakar, G, 1995)

Timeframe	Studies, this research(%)	All Research%
pre-1990	16 (41.03)	18.7374
1990's	7 (17.95)	18.2507
2000's	6 (15.38)	29.6817
2010's	6 (15.38)	24.3611
2020's	4 (10.26)	2.80

Authors	Studies
Le Picault, B	1
Pavy, C	1
Maminirina, P	1
Benbrik, N	1
Baron, O	1
Yu, T	1
Pu, H	1
Chen, X	1
Kong, Q	1
Chen, C	1
Li, G	1
Jiang, Q	1
Wang, Y	1
Zhuravleva, IY	1
Karpova, EV	1
Dokuchaeva, AA	1
Titov, AT	1
Timchenko, TP	1
Vasilieva, MB	1
Sá, MPBO	1
Perazzo, ÁM	1
Zhigalov, K	1
Komarov, R	1
Kadyraliev, B	1
Enginoev, S	1
Ennker, J	1
Popov, AF	1
Quarto, C	1
Weymann, A	1
Lima, RC	1
Liu, J	1
Li, B	1
Jing, H	1
Qin, Y	1
Wu, Y	1
Kong, D	1
Leng, X	1
Wang, Z	1
Park, CS	1
Kim, YJ	1
Lee, JR	1
Lim, HG	1
Chang, JE	1
Jeong, S	1
Kwon, N	1
Ozaki, S	2
Kawase, I	1
Yamashita, H	1
Uchida, S	1
Takatoh, M	1
Kiyohara, N	1
Nakamura, K	1
Hashimoto, K	1
Sakamoto, Y	1
Bando, K	1
Yoshitake, M	1
Matsumura, Y	1
Kinouchi, K	1
Abe, T	3
Agathos, EA	1
Tomos, PI	1
Kostomitsopoulos, N	1
Koutsoukos, PG	1
Honge, JL	1
Funder, JA	1
Pedersen, TB	1
Kronborg, MB	1
Hasenkam, JM	1
Simionescu, DT	1
Lovekamp, JJ	1
Vyavahare, NR	1
Santos, PC	1
Gerola, LR	1
Casagrande, I	1
Buffolo, E	1
Cheung, DT	1
Hellberg, K	1
Ruschewski, W	1
de Vivie, ER	1
Antunes, MJ	1
Santos, LP	1
Camilleri, JP	2
Pornin, B	1
Carpentier, A	2
Kumar, SP	1
Ali, ML	1
Prabhakar, G	1
Becker, A	1
Duran, CM	1
Bianco, RW	1
Phillips, R	1
Mrachek, J	1
Witson, J	1
Chanda, J	2
Kuribayashi, R	2
Sekine, S	1
Shibata, Y	1
Yamagishi, I	1
Schoen, FJ	1
Walther, T	1
Falk, V	1
Diegeler, A	1
Rauch, T	1
Weigl, C	1
Gummert, J	1
Autschbach, R	1
Mohr, FW	1
Human, P	2
Weissenstein, C	1
Trantina, A	1
Zilla, P	2
Meuris, B	1
Herijgers, P	1
Verbeken, E	1
Flameng, W	1
Nimni, ME	1
Barratt-Boyes, BG	1
Lurie, AJ	1
Miller, RR	1
Maxwell, KS	1
Grehl, TM	1
Vismara, LA	1
Hurley, EJ	1
Mason, DT	1
Cévese, PG	1
Gallucci, V	1
Morea, M	1
Dalla Volta, S	1
Fasoli, G	1
Casarotto, D	1
Spray, TL	1
Roberts, WC	1
Cohn, LH	2
Rose, AG	1
Forman, R	1
Bowen, RM	1
Wallace, RB	1
Lambert, JJ	1
Castaneda, AR	1
Collins, JJ	1
Zuhdi, N	1
Valente, M	1
Minarini, M	1
Ius, P	1
Talenti, E	1
Bortolotti, U	1
Milano, A	1
Thiene, G	1
Jamieson, WR	2
Janusz, MT	2
Miyagishima, RT	2
Munro, AI	2
Gerein, AN	2
Allen, P	2
Burr, LH	2
MacNab, J	1
Chan, F	1
Tyers, GF	1
Ling, H	1
Hayden, RI	1
Tutassura, H	1
Brais, MP	1
Bédard, JP	1
Goldstein, W	1
Koshal, A	1
Keon, WJ	1
Deloche, A	1
Relland, J	1
Fabiani, JN	1
Forman, J	1
Soyer, R	1
Dubost, C	1

Article	Year
Aortic Valve Neocuspidization with Glutaraldehyde-Treated Autologous Pericardium (Ozaki Procedure) - A Promising Surgical Technique. Brazilian journal of cardiovascular surgery, 2019, 12-01, Volume: 34, Issue:5 Topics: Aortic Valve; Cardiac Valve Annuloplasty; Glutaral; Heart Valve Diseases; Humans; Pericardium; Reope	2019
Glutaraldehyde fixation revisited. Journal of long-term effects of medical implants, 2001, Volume: 11, Issue:3-4 Topics: Animals; Bioprosthesis; Calcinosis; Collagen; Cross-Linking Reagents; Fixatives; Glutaral; Heart Val	2001
Inflammatory and immune processes: the neglected villain of bioprosthetic degeneration? Journal of long-term effects of medical implants, 2001, Volume: 11, Issue:3-4 Topics: Animals; Antigen Presentation; Bioprosthesis; Calcinosis; Cross-Linking Reagents; Fixatives; Foreign	2001
Surgical treatment of valvular heart disease. American journal of surgery, 1978, Volume: 135, Issue:3 Topics: Animals; Aortic Valve; Glutaral; Heart Valve Diseases; Heart Valve Prosthesis; Hemodynamics; History	1978
Tissue valves. The American journal of cardiology, 1975, Volume: 35, Issue:6 Topics: Anti-Bacterial Agents; Anti-Infective Agents, Local; Aortic Valve; Fascia; Fascia Lata; Glutaral; He	1975

Article	Year
Medium-term follow-up of autologous pericardial patches for pediatric aortic arch reconstruction. Journal of cardiac surgery, 2022, Volume: 37, Issue:10 Topics: Aorta, Thoracic; Aortic Coarctation; Child; Follow-Up Studies; Glutaral; Heart Valve Diseases; Human	2022
A versatile modification strategy for functional non-glutaraldehyde cross-linked bioprosthetic heart valves with enhanced anticoagulant, anticalcification and endothelialization properties. Acta biomaterialia, 2023, 04-01, Volume: 160 Topics: Animals; Anticoagulants; Bioprosthesis; Calcinosis; Cross-Linking Reagents; Endothelial Cells; Gluta	2023
Calcification of Various Bioprosthetic Materials in Rats: Is It Really Different? International journal of molecular sciences, 2023, Apr-14, Volume: 24, Issue:8 Topics: Animals; Bioprosthesis; Calcinosis; Calcium; Cattle; Collagen; Elastin; Glutaral; Heart Valve Diseas	2023
Curcumin-crosslinked acellular bovine pericardium for the application of calcification inhibition heart valves. Biomedical materials (Bristol, England), 2020, 05-05, Volume: 15, Issue:4 Topics: Animals; Bioprosthesis; Calcification, Physiologic; Cattle; Collagen; Cross-Linking Reagents; Curcum	2020
Anticalcification effect of a combination of decellularization, organic solvents and amino acid detoxification on glutaraldehyde-fixed xenopericardial heart valves in a large-animal long-term circulatory model. Interactive cardiovascular and thoracic surgery, 2017, 09-01, Volume: 25, Issue:3 Topics: Amino Acids; Animals; Bioprosthesis; Calcinosis; Calcium; Cattle; Disease Models, Animal; Echocardio	2017
Midterm outcomes after aortic valve neocuspidization with glutaraldehyde-treated autologous pericardium. The Journal of thoracic and cardiovascular surgery, 2018, Volume: 155, Issue:6 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Animals; Aortic Valve; Cattle; Female; Glutaral; Heart V	2018
Safe Use of Glutaraldehyde to Repair the Destroyed Valve in Active Infective Mitral Valve Endocarditis. Circulation journal : official journal of the Japanese Circulation Society, 2018, 09-25, Volume: 82, Issue:10 Topics: Animals; Cardiac Surgical Procedures; Cattle; Endocarditis; Glutaral; Heart Valve Diseases; Humans;	2018
Calcitonin as an anticalcification treatment for implantable biological tissues. Journal of cardiology, 2019, Volume: 73, Issue:2 Topics: Animals; Bioprosthesis; Calcinosis; Calcitonin; Calcium-Regulating Hormones and Agents; Glutaral; He	2019
Degenerative processes in bioprosthetic mitral valves in juvenile pigs. Journal of cardiothoracic surgery, 2011, May-15, Volume: 6 Topics: Animals; Bioprosthesis; Calcinosis; Disease Models, Animal; Echocardiography; Female; Glutaral; Graf	2011
Glycosaminoglycan-degrading enzymes in porcine aortic heart valves: implications for bioprosthetic heart valve degeneration. The Journal of heart valve disease, 2003, Volume: 12, Issue:2 Topics: Animals; Aortic Valve; Bioprosthesis; Calcinosis; Calcium; Chondroitinases and Chondroitin Lyases; D	2003
Stentless valves treated by the L-hydro process in the aortic position in sheep. Asian cardiovascular & thoracic annals, 2007, Volume: 15, Issue:5 Topics: Animals; Aortic Valve; Bioprosthesis; Calcinosis; Equipment Failure Analysis; Female; Fixatives; Glu	2007
Early stenosis and calcification of glutaraldehyde-preserved porcine xenografts in children. The Thoracic and cardiovascular surgeon, 1981, Volume: 29, Issue:6 Topics: Adolescent; Aldehydes; Animals; Aortic Valve; Bioprosthesis; Calcinosis; Child; Child, Preschool; Fe	1981
Performance of glutaraldehyde-preserved porcine bioprosthesis as a mitral valve substitute in a young population group. The Annals of thoracic surgery, 1984, Volume: 37, Issue:5 Topics: Adolescent; Adult; Aged; Aldehydes; Bioprosthesis; Child; Female; Glutaral; Heart Valve Diseases; Hu	1984
Structural changes of glutaraldehyde- treated porcine bioprosthetic valves. Archives of pathology & laboratory medicine, 1982, Volume: 106, Issue:10 Topics: Adolescent; Adult; Aged; Aldehydes; Aortic Valve; Bioprosthesis; Calcinosis; Child; Collagen; Connec	1982
In situ mitral valve stabilization with glutaraldehyde. The Journal of heart valve disease, 1995, Volume: 4, Issue:4 Topics: Animals; Calcinosis; Calcium; Chordae Tendineae; Disease Models, Animal; Echocardiography, Doppler;	1995
Feasibility evaluation of a new pericardial bioprosthesis with dye mediated photo-oxidized bovine pericardial tissue. The Journal of heart valve disease, 1996, Volume: 5, Issue:3 Topics: Angiography; Animals; Bioprosthesis; Calcinosis; Cattle; Coloring Agents; Evaluation Studies as Topi	1996
Is the dog a useful model for accelerated calcification study of cardiovascular bioprostheses? Artificial organs, 1997, Volume: 21, Issue:5 Topics: Animals; Aorta, Thoracic; Biocompatible Materials; Bioprosthesis; Calcinosis; Cattle; Chelating Agen	1997
Heparin in calcification prevention of porcine pericardial bioprostheses. Biomaterials, 1997, Volume: 18, Issue:16 Topics: Animals; Anticoagulants; Biocompatible Materials; Bioprosthesis; Calcinosis; Calcium; Cross-Linking	1997
Pathologic findings in explanted clinical bioprosthetic valves fabricated from photooxidized bovine pericardium. The Journal of heart valve disease, 1998, Volume: 7, Issue:2 Topics: Aged; Aged, 80 and over; Animals; Aortic Valve; Aortic Valve Insufficiency; Bioprosthesis; Calcinosi	1998
Effectiveness of different anticalcification treatments for stentless aortic bioprostheses. The Thoracic and cardiovascular surgeon, 1999, Volume: 47, Issue:1 Topics: Aluminum Chloride; Aluminum Compounds; Animals; Aorta, Thoracic; Aortic Diseases; Aortic Valve; Astr	1999
Fixation-related autolysis and bioprosthetic aortic wall calcification. The Journal of heart valve disease, 2001, Volume: 10, Issue:5 Topics: Animals; Aorta; Aortic Valve; Autolysis; Bioprosthesis; Calcinosis; Calcium; Cardiovascular Surgical	2001
Influence of species, environmental factors, and tissue cellularity on calcification of porcine aortic wall tissue. Seminars in thoracic and cardiovascular surgery, 2001, Volume: 13, Issue:4 Suppl 1 Topics: Animals; Aorta; Bioprosthesis; Calcinosis; Carotid Arteries; Cross-Linking Reagents; Disease Models,	2001
Hemodynamic assessment of the glutaraldehyde-preserved porcine heterograft in the aortic and mitral positions. Circulation, 1977, Volume: 56, Issue:3 Suppl Topics: Adolescent; Adult; Aged; Aldehydes; Animals; Aortic Valve; Cardiac Catheterization; Cardiac Output;	1977
Heart valve replacement with the Hancock bioprosthesis. Analysis of long-term results. Circulation, 1977, Volume: 56, Issue:3 Suppl Topics: Adolescent; Adult; Aged; Animals; Aortic Valve; Child; Female; Follow-Up Studies; Glutaral; Heart Va	1977
Structural changes in Hancock porcine xenograft cardiac valve bioprostheses. Advances in cardiology, 1978, Issue:22 Topics: Animals; Aortic Valve; Glutaral; Graft Rejection; Heart Valve Diseases; Heart Valves; Humans; Swine;	1978
Calcification of glutaraldehyde-fixed porcine xenograft. Thorax, 1978, Volume: 33, Issue:1 Topics: Adolescent; Aldehydes; Animals; Calcinosis; Connective Tissue; Glutaral; Heart Valve Diseases; Heart	1978
Cardiac valve replacement with the stabilized glutaraldehyde porcine aortic valve: indications, operative results, and followup. Chest, 1975, Volume: 68, Issue:2 Topics: Adolescent; Adult; Aged; Animals; Aortic Valve; Boston; Child; Child, Preschool; Female; Glutaral; H	1975
The porcine aortic valve bioprosthesis: a significant alternative. The Annals of thoracic surgery, 1976, Volume: 21, Issue:6 Topics: Animals; Aortic Valve; Aortic Valve Insufficiency; Calcinosis; Follow-Up Studies; Glutaral; Heart Va	1976
Durability of glutaraldehyde-fixed pericardial valve prostheses: clinical and animal experimental studies. The Journal of heart valve disease, 1992, Volume: 1, Issue:2 Topics: Adult; Aged; Animals; Bioprosthesis; Calcinosis; Cattle; Fixatives; Glutaral; Heart Valve Diseases;	1992
The Carpentier-Edwards standard porcine bioprosthesis: long-term evaluation of the high pressure glutaraldehyde fixed prosthesis. Journal of cardiac surgery, 1988, Volume: 3, Issue:3 Suppl Topics: Adolescent; Adult; Aged; Aged, 80 and over; Bioprosthesis; British Columbia; Cause of Death; Child;	1988
The Carpentier-Edwards supra-annular porcine bioprosthesis: new generation low pressure glutaraldehyde fixed prosthesis. Journal of cardiac surgery, 1988, Volume: 3, Issue:4 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aortic Valve; Bioprosthesis; British Columbia; Cause of	1988
Ionescu-Shiley pericardial xenografts: follow-up of up to 6 years. The Annals of thoracic surgery, 1985, Volume: 39, Issue:2 Topics: Actuarial Analysis; Aortic Valve; Embolism; Endocarditis, Bacterial; Follow-Up Studies; Glutaral; He	1985
Six-year follow-up of glutaraldehyde-preserved heterografts. With particular reference to the treatment of congenital valve malformations. The Journal of thoracic and cardiovascular surgery, 1974, Volume: 68, Issue:5 Topics: Adolescent; Adult; Aldehydes; Aortic Valve; Child; Ebstein Anomaly; Female; Follow-Up Studies; Gluta	1974

glutaral and Heart Valve Diseases

Research Excerpts

Research

Studies (39)

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