glutamine and Pancreatic Neoplasms

glutamine has been researched along with Pancreatic Neoplasms in 98 studies

Research

Studies (98)

Timeframe	Studies, this research(%)	All Research%
pre-1990	7 (7.14)	18.7374
1990's	4 (4.08)	18.2507
2000's	4 (4.08)	29.6817
2010's	46 (46.94)	24.3611
2020's	37 (37.76)	2.80

Authors

Authors	Studies
Atri, P; Batra, SK; Bhatia, R; Cox, JL; Ganguly, K; Kaur, S; Kisling, A; Kumar, S; Mallya, K; Ram Krishn, S; Rauth, S; Shinde, D; Thomas, V; Thompson, C; Vengoji, R	1
Affronti, H; Blair, IA; Blenis, J; Campbell, S; Izzo, L; Kruijning, S; Mesaros, C; Noji, M; Schaffer, BE; Sun, K; Trefely, S; Tsang, T; Wellen, KE	1
Chen, L; Gu, X; Han, F; Li, H; Li, M; Shang, L; Yang, Y; Zheng, M	1
Chen, H; Pan, H; Ren, F; Ren, P; Wang, W	1
Fu, H; Guo, Y; Hu, P; Shi, J; Xu, Y; Yu, Z	1
Curukovic, A; DeBerardinis, RJ; Huerta-Rosario, M; Jeong, MH; Jewell, JL; Lama-Sherpa, TD; Lewis, C; Melick, CH; Meng, D; Tiwary, S; Urquhart, G; Wang, H; Yang, Q; Zacharias, LG	1
Andreani, S; Bacci, M; Cappello, P; Corbo, V; Costamagna, A; De Santis, MC; Delfino, P; Di Gregorio, E; Giovannetti, E; Gozzelino, L; Gulluni, F; Hirsch, E; Lattanzio, R; Lorito, N; Margaria, JP; Martini, M; Mina, E; Morandi, A; Novelli, F; Porporato, PE; Ratto, E; Sala, G; Scarpa, A; Vicentini, C	1
Hu, M; Huang, P; Kong, B; Li, Y; Ling, S; Liu, H; Ma, Y	1
Lam, BQ; Ma, Y; Roy, SK; Shankar, S; Shrivastava, A; Srivastav, S; Srivastava, RK	1
Fan, Z; Geng, D; Lai, Z; Qin, W; Wang, Y; Wu, L; Yang, W; Yi, W; Zhang, J; Zhou, H; Zhou, R; Zhu, Q	1
Inoue, H; Kageyama, S; Kawauchi, A; Kim, CJ; Minami, K; Shirasawa, S; Tambe, Y; Tanaka, H; Terado, T; Tsunoda, T; Ushio, A	1
Bai, J; DuFort, CC; Fan, M; Fu, D; Hu, Z; Huo, S; Li, H; Pang, H; Shu, Z; Tu, B; Wang, L; Wang, W; Yao, K; Ying, H; Yuan, M; Zhai, J; Zhang, N; Zhao, Y; Zhu, WG	1
Chang, JS; Chen, HA; Chiu, CF; Hsu, TW; Lin, CY; Park, JM; Peng, JM; Saengboonmee, C; Shan, YS; Shen, YS; Su, YH	1
Chen, L; Dai, M; Guo, W; Li, R; Liang, Z; Liu, H; Liu, Q; Liu, X; Pang, J; Tong, WM; Wu, H; Zhang, H	1
Ahn, E; Ahn, T; Bang, S; Choi, J; Han, JM; Hwang, GS; Kim, K; Kim, Y; Lee, HS; Luo, E; Min, DS; Park, SJ; Sung, Y; Yoo, HC; Yu, YC	1
Chen, H; Gao, HF; Li, YJ; Liu, LM; Peng, LJ; Zhang, K	1
Amano, H; Dash, S; Honda, M; Kawazu, M; Komuro, A; Okada, H; Ueda, T	1
Dai, Z; Deng, S; Gu, W; Liu, C; Liu, H; Liu, Y; Luo, G; Ni, Q; Wang, R; Xiao, Z; Yu, X	1
Aguera, K; Andrivon, A; Blachier, J; Châlons-Cottavoz, M; Cleret, A; Fanjat, JM; Gallix, F; Gay, F; Gil, C; Guerin, N; Horand, F; Laperrousaz, B; Piedrahita, D; Rama, N; Rossignol, R; Tavernier, F; Vidault, L	1
Caisova, V; Chmelar, J; Frejlachova, A; Hansen, P; Kopecky, J; Lencova, R; Majer, P; Pacak, K; Skalickova, M; Tenora, L; Uher, O; Venhauerova, A; Zenka, J; Zhuang, Z	1
Awad, D; Lyssiotis, CA	1
Cai, K; Han, S; Hu, P; Hu, Y; Huang, Y; Li, Y; Lv, G; Wang, D; Wang, F; Wang, H; Wang, J; Zeng, Z; Zhao, E; Zhao, G; Zhao, Y; Zhuo, W	1
Cheng, Q; Fu, S; Li, QI; Ren, P; Wang, W; Wu, NA	1
Cheong, JH; Hong, WC; Kang, HW; Kim, HJ; Kim, HS; Kim, JH; Kim, M; Kim, MJ; Lee, DE; Park, JS	1
Li, H; Luan, S; Qi, C; Sun, W; Tong, Q; Yan, S; Zhang, Y	1
Anthony, TG; Bhatt, V; Bott, AJ; Chiles, E; Crawford, HC; Dai, W; Feng, H; Guo, JY; Jiang, YP; Jin, J; Lamers, WH; Lin, RZ; Maimouni, S; Morton, J; Murphy, DJ; Muthalagu, N; Pan, JA; Shen, J; Sivaram, N; Su, X; Tonelli, C; Tuveson, DA; Velasquez, S; White, E; Yu, X; Zhan, L; Zhang, L; Zhong, H; Zong, WX	1
Birsoy, K; Zhu, XG	1
Almagro, J; Barry, DJ; Behrens, A; Carvalho, J; Evan, T; Ferreira, RMM; Frith, D; Herbert, E; Legrave, N; MacRae, JI; Nye, EL; Snijders, AP; Wang, VM; Zaw Thin, M	1
Adiseshaiah, PP; Burgan, W; Goswami, D; Guerin, TM; Kozlov, SV; McCormick, F; Mukhopadhyay, S; Nissley, DV; Yi, M	1
Hu, M; Huang, P; Kong, B; Li, X; Li, Y; Ling, S; Ma, Y	1
Bagchi, A; Commisso, C; Galenkamp, KMO; James, B; Jung, M; Lowy, A; Moldenhauer, MR; Recouvreux, MV; Zhang, Y	1
Josselsohn, RH; Tuveson, DA	1
Commisso, C; Lee, SW	2
Gustafsson, JÅ; Ho, C; Lin, CY; Nguyen, A; Nguyen, D; Premaratne, A; Srivastava, S; Widmann, S	1
Chen, G; Luo, W; Qiu, J; Tao, J; Yang, G; You, L; Zhang, T; Zhao, F; Zhao, Y; Zheng, L; Zhou, W	1
Cui, J; Guo, Y; Liu, K; Peng, T; Wu, H; Xiong, J; Zhou, X	1
Makino, I; Miyashita, T; Ohta, T; Okazaki, M; Tajima, H	1
Fang, J; Guo, D; Jiang, Y; Li, L; Li, M; Liang, J; Lin, SH; Lu, Z; Ma, C; Shao, F; Tong, Y; Yang, D; Yu, Q; Yu, R	1
Jang, EJ; Muyinda, IJ; Park, JG; Yoo, BC	1
Abrego, J; Dasgupta, A; Goode, G; Gunda, V; King, RJ; Murthy, D; Shukla, SK; Singh, PK; Vernucci, E; Yu, F	1
Chen, C; Chen, R; Fu, Z; Li, W; Li, Z; Nong, T; Pan, W; Wei, L; Ye, H; Zhao, X; Zhao, Y; Zheng, S	1
Biancur, DE; Chu, GC; Fendler, W; Gygi, SP; Harper, JW; Kimmelman, AC; Mancias, JD; Małachowska, B; Paulo, JA; Quiles Del Rey, M; Sohn, ASW; Sousa, CM; Wang, X	1
Brentnall, TA; Chen, R; Jung, L; Lai, LA; Pan, S; Pillarisetty, VG; Riddell, J; Sullivan, Y; Wang, L; Wong, M	1
Abrego, J; Chaika, NV; Gebregiworgis, T; Gunda, V; Mulder, SE; Powers, R; Purohit, V; Shukla, SK; Singh, PK; Tadros, S	1
Esparza, LA; Ghergurovich, JM; Hui, S; Jang, C; Lu, W; Morscher, RJ; Rabinowitz, JD; Reya, T; Teng, X; White, E; Yanxiang Guo, J	1
Fujimura, K; Klemke, RL; Wang, H; Watson, F	1
Hwang, S; Jeong, SM; Kim, M; Lee, JH; Seo, SB; Yang, S	1
Chakravarthy, D; Chan, DE; Ghosh, R; Halff, G; Hwang, RF; Keppler, BR; Kumar, AP; Muñoz, AR; Su, A	1
Beg, MS; Hosein, AN	1
Dasgupta, A; Gunda, V; King, RJ; Shukla, SK; Singh, PK	1
Iwase, Y; Matsumoto, A; Nishi, K; Otagiri, M; Suzuki, M; Yamamoto, N; Yamasaki, K; Yumita, N	1
de van der Schueren, MAE; Meijerink, MR; Scheffer, HJ; van Bodegraven, AA; Vroomen, LG; Wierdsma, NJ; Witvliet-van Nierop, JE	1
Chen, W; Ren, H; Wang, B; Wang, J	1
Cheng, HM; Jing, D; Li, J; Li, P; Thu, PM; Wang, YY; Xu, X; Zhang, X; Zheng, ZG; Zhou, YP	1
Gil, Z; Hanse, EA; Ishak Gabra, MB; Kong, M; Li, H; Liu, J; Locasale, JW; Lowman, XH; Milman, N; Reid, MA; Tran, TQ; Yang, Y	1
Fest, J; Goeman, JJ; Haller, T; Hveem, K; Ikram, A; Joensuu, A; Männistö, S; Metspalu, A; Mikkel, K; Ness-Jensen, E; Perola, M; Ruiter, R; Stricker, BH; Tonisson, N; van Duijn, CM; van Eijck, CHJ; van Ommen, GB; Veth, O; Vijfhuizen, LS; ʼt Hoen, PAC	1
Banerjee, S; Kesh, K	1
Asaka, R; Cooper, AJL; Elgogary, A; Fu, J; Hanes, J; Hoang, G; Jung, JG; Le, A; Nguyen, K; Nguyen, S; Nguyen, T; Pham, K; Quinones, A; Slusher, BS; Thomas, AG; Tsukamoto, T; Udupa, S; Xu, Q; Zhang, C	1
Alas, B; Commisso, C; Cruz, N; Jung, M; Lee, SW; Zhang, Y	1
Berthezène, P; Calvo, E; Dusetti, NJ; Guillaumond, F; Iovanna, JL; Lavaut, MN; Leca, J; Loncle, C; Olivares, O; Tomasini, R; Turrini, O; Vasseur, S; Vidal, N	1
Asara, JM; Bardeesy, N; Cantley, LC; DePinho, RA; Ferrone, CR; Fleming, JB; Haigis, MC; Hua, S; Kang, Y; Kimmelman, AC; Ligorio, M; Lyssiotis, CA; Mullarky, E; Perera, RM; Shyh-Chang, N; Son, J; Wang, X; Ying, H	1
Bar-Sagi, D; Commisso, C; Davidson, SM; Drebin, JA; Grabocka, E; Hackett, S; Kamphorst, JJ; Metallo, CM; Nofal, M; Parker, SJ; Rabinowitz, JD; Soydaner-Azeloglu, RG; Thompson, CB; Vander Heiden, MG	1
Chun, MG; Shaw, RJ	1
Cantley, LC; Kimmelman, AC; Lyssiotis, CA; Son, J	1
Costanzo, C; D'Alessandro, A; Dalla Pozza, E; Dando, I; Donadelli, M; Palmieri, M; Zolla, L	1
Liotta, LA; Petricoin, EF; Zhou, W	1
Bryant, KL; Der, CJ; Kimmelman, AC; Mancias, JD	1
Guillaumond, F; Iovanna, JL; Vasseur, S	1
Bar-Sagi, D; Commisso, C; Drebin, JA; Grabocka, E; Hackett, SR; Kamphorst, JJ; Lu, W; Miller, G; Nofal, M; Rabinowitz, JD; Thompson, CB; Vander Heiden, MG	1
Chen, R; Fu, Z; Gao, W; Li, Z; Lin, Q; Lin, Y; Liu, Y; Tan, L; Ye, X; Yu, M; Zeng, B; Zhou, J; Zhou, Q; Zhou, Y	1
Chen, R; Fu, Z; Gao, W; Li, D; Li, Z; Lin, Q; Liu, Y; Ye, H; Yu, M; Zeng, B; Zhao, X; Zhou, J; Zhou, Q; Zhou, Y	1
Allen, E; Hanahan, D; Li, L; Miéville, P; Peng, MW; Saghafinia, S; Warren, CM	1
Alt, J; Chen, B; Elgogary, A; Fu, J; Hanes, J; Hartung, T; Le, A; Lee, R; Liu, Y; Neisser, M; Nguyen, C; Park, JK; Poore, B; Rais, R; Reyes, J; Rojas, C; Semenza, GL; Slusher, BS; Tsukamoto, T; Xia, S; Xu, Q; Zhao, L; Zimmermann, SC	1
Balaji, U; Freinkman, E; Knudsen, ES; McCue, P; Witkiewicz, AK	1
Cheng, JK; Gao, X; Huang, X; Lei, QY; Liu, YB; Wang, J; Wang, TS; Wang, YP; Xu, YY; Zhou, W; Zou, SW; Zuo, Y	1
Halbrook, CJ; Lyssiotis, CA	1
Agle, S; Hayat, T; Martin, RC; McMasters, KM; Philips, P; Schlegel, M; Scoggins, CR	1
Fischer, SM; Loo, JA; Matyska, MT; Pesek, JJ; Sana, TR	1
Capello, M; Fredolini, C; Liotta, LA; Novelli, F; Petricoin, EF; Piemonti, L; Racanicchi, L; Zhou, W	1
Fei, S; Ji, Y; Rao, S; Wang, H; Yao, X; Zeng, M	1
Brown, RB; Caffrey, T; Chaika, NV; Gebregiworgis, T; Hollingsworth, MA; Johnson, KR; Lewallen, ME; Liu, X; Mehla, K; Powers, R; Purohit, V; Radhakrishnan, P; Singh, PK; Yu, F; Zhang, B	1
Dang, CV; Le, A; Maitra, A; Rajeshkumar, NV	1
Kwon, SJ; Lee, YJ	1
Abbruzzese, JL; Bondy, ML; Evans, DB; Hassan, MM; Jiao, L; Li, D	1
Hedeskov, CJ; Knudsen, P; Kofod, H; Lernmark, A	1
Bouwens, L; De Vos, A; Heimberg, H; Madsen, O; Moens, K; Pipeleers, D; Quartier, E; Schuit, F; Van Schaftingen, E	1
Bode, HP; Fehmann, HC; Göke, B; Weber, S	1
von Meyenfeldt, MF	1
Anno, T; Furukawa, S; Inoue, H; Koga, M; Matsuo, K; Nakai, K; Ohta, Y; Oka, Y; Sasaki, T; Tanizawa, Y	1
Arimura, GK; Wu, MC; Yunis, AA	1
Castro-Bello, F; Marina-Fiol, C; Ramos, F; Vivanco, F	1
Bastié, MJ; Pradayrol, L; Scemama, JL; Seva, C; Vaysse, N	1
de Jong, AJ; Douglas, BR; Jansen, JB; Lamers, CB; Rovati, LC; Woutersen, RA	1
Ollenschläger, G; Roth, E; Simmel, A	1
Blachier, F; Malaisse, WJ; Sener, A	1
Archer, MC; Chan, AM; Zucker, PF	1

Reviews

10 review(s) available for glutamine and Pancreatic Neoplasms

Article	Year
Targeting hypoxic tumor microenvironment in pancreatic cancer. Journal of hematology & oncology, 2021, 01-13, Volume: 14, Issue:1 Topics: Animals; Antineoplastic Agents; Autophagy; Cell Movement; Epithelial-Mesenchymal Transition; Glucose; Glutamine; Humans; Molecular Targeted Therapy; Neoplasm Invasiveness; Neovascularization, Pathologic; Pancreatic Neoplasms; Tumor Hypoxia; Tumor Microenvironment	2021
[Intestinal Care Using L‒Glutamine Supplement and Probiotics Can Induce a Strong Anti‒Tumor Immune Response through the Induction of Mature Tertiary Lymphoid Structures in Pancreatic Cancer Patients Receiving Preoperative Chemotherapy]. Gan to kagaku ryoho. Cancer & chemotherapy, 2021, Volume: 48, Issue:4 Topics: Glutamine; Humans; Immunity; Intestinal Mucosa; Pancreatic Neoplasms; Probiotics; Tertiary Lymphoid Structures	2021
KRAS, A Prime Mediator in Pancreatic Lipid Synthesis through Extra Mitochondrial Glutamine and Citrate Metabolism. International journal of molecular sciences, 2021, May-11, Volume: 22, Issue:10 Topics: Citrates; Glutamine; Humans; Lipids; Mitochondria; Pancreas; Pancreatic Neoplasms; Proto-Oncogene Proteins p21(ras)	2021
Pancreatic Cancer Metabolism: Molecular Mechanisms and Clinical Applications. Current oncology reports, 2018, 05-11, Volume: 20, Issue:7 Topics: Acrylamides; Adenocarcinoma; Antineoplastic Agents; Citric Acid Cycle; Glutaminase; Glutamine; Humans; Mitochondria; Molecular Targeted Therapy; NAD; NAD(P)H Dehydrogenase (Quinone); Pancreatic Neoplasms; Piperidines	2018
Cancer metabolism and mass spectrometry-based proteomics. Cancer letters, 2015, Jan-28, Volume: 356, Issue:2 Pt A Topics: Animals; Cell Hypoxia; Glioblastoma; Glutamine; Glycolysis; Humans; Isoenzymes; L-Lactate Dehydrogenase; Lactate Dehydrogenase 5; Lactic Acid; Mass Spectrometry; Mice; Oxidative Stress; Pancreatic Neoplasms; Protein Processing, Post-Translational; Proteomics; Pyruvate Kinase	2015
KRAS: feeding pancreatic cancer proliferation. Trends in biochemical sciences, 2014, Volume: 39, Issue:2 Topics: Autophagy; Carcinoma, Pancreatic Ductal; Cell Proliferation; Gene Expression Regulation, Neoplastic; Glucose; Glutamine; Humans; Isoenzymes; Mutation; Pancreatic Neoplasms; Pinocytosis; Protein Structure, Tertiary; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); ras Proteins; Signal Transduction	2014
Pancreatic tumor cell metabolism: focus on glycolysis and its connected metabolic pathways. Archives of biochemistry and biophysics, 2014, Mar-01, Volume: 545 Topics: Animals; Carcinoma, Pancreatic Ductal; Cell Hypoxia; Glutamine; Glycolysis; Glycosylation; Hexosamines; Humans; Metabolic Networks and Pathways; Pancreas; Pancreatic Neoplasms	2014
Employing Metabolism to Improve the Diagnosis and Treatment of Pancreatic Cancer. Cancer cell, 2017, 01-09, Volume: 31, Issue:1 Topics: Carcinoma, Pancreatic Ductal; Cellular Reprogramming; Fluorodeoxyglucose F18; Glucose; Glutamine; Humans; Metformin; Pancreatic Neoplasms; Positron-Emission Tomography; Tumor Microenvironment	2017
Conceptual framework for cutting the pancreatic cancer fuel supply. Clinical cancer research : an official journal of the American Association for Cancer Research, 2012, Aug-15, Volume: 18, Issue:16 Topics: Animals; Antineoplastic Agents; Carcinoma, Pancreatic Ductal; Glucose; Glutamine; Humans; Metabolic Networks and Pathways; Pancreatic Neoplasms	2012
Nutritional support during treatment of biliopancreatic malignancy. Annals of oncology : official journal of the European Society for Medical Oncology, 1999, Volume: 10 Suppl 4 Topics: Arginine; Biliary Tract Neoplasms; Eicosapentaenoic Acid; Glutamine; Humans; Nutritional Support; Pancreatic Neoplasms	1999

Trials

1 trial(s) available for glutamine and Pancreatic Neoplasms

Article	Year
Efficacy of preoperative immunonutrition in locally advanced pancreatic cancer undergoing irreversible electroporation (IRE). European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 2017, Volume: 43, Issue:4 Topics: Ablation Techniques; Adenocarcinoma; Adult; Aged; Aged, 80 and over; Amino Acids, Branched-Chain; Arginine; Dietary Supplements; Electroporation; Enteral Nutrition; Fatty Acids, Omega-3; Female; Glutamine; Humans; Immunomodulation; Male; Middle Aged; Nucleotides; Nutritional Status; Pancreatic Neoplasms; Pilot Projects; Postoperative Complications; Preoperative Care; Treatment Outcome; Weight Loss	2017

Article

Year

Efficacy of preoperative immunonutrition in locally advanced pancreatic cancer undergoing irreversible electroporation (IRE).

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 2017, Volume: 43, Issue:4

Topics: Ablation Techniques; Adenocarcinoma; Adult; Aged; Aged, 80 and over; Amino Acids, Branched-Chain; Arginine; Dietary Supplements; Electroporation; Enteral Nutrition; Fatty Acids, Omega-3; Female; Glutamine; Humans; Immunomodulation; Male; Middle Aged; Nucleotides; Nutritional Status; Pancreatic Neoplasms; Pilot Projects; Postoperative Complications; Preoperative Care; Treatment Outcome; Weight Loss

2017

Other Studies

87 other study(ies) available for glutamine and Pancreatic Neoplasms

Article	Year
Mucin 5AC Serves as the Nexus for β-Catenin/c-Myc Interplay to Promote Glutamine Dependency During Pancreatic Cancer Chemoresistance. Gastroenterology, 2022, Volume: 162, Issue:1 Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; beta Catenin; Cell Line, Tumor; Databases, Genetic; Deoxycytidine; Drug Resistance, Neoplasm; Energy Metabolism; Enzyme Inhibitors; Female; Gemcitabine; Gene Expression Regulation, Neoplastic; Glutaminase; Glutamine; Humans; Male; Mice, Knockout; Mice, Nude; Mucin 5AC; Pancreatic Neoplasms; Proto-Oncogene Proteins c-myc; Signal Transduction; Tumor Cells, Cultured; Xenograft Model Antitumor Assays	2022
Glutamine deprivation triggers NAGK-dependent hexosamine salvage. eLife, 2021, 11-30, Volume: 10 Topics: Animals; Carcinoma, Pancreatic Ductal; Cell Line; Glutamine; Hexosamines; Humans; Mice; Mice, Nude; Pancreatic Neoplasms; Phosphotransferases (Alcohol Group Acceptor)	2021
Ziprasidone suppresses pancreatic adenocarcinoma cell proliferation by targeting GOT1 to trigger glutamine metabolism reprogramming. Journal of molecular medicine (Berlin, Germany), 2022, Volume: 100, Issue:4 Topics: Adenocarcinoma; Aspartate Aminotransferase, Cytoplasmic; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Proliferation; Glutamine; Humans; Pancreatic Neoplasms; Piperazines; Thiazoles	2022
Targeting ASCT2-mediated glutamine metabolism inhibits proliferation and promotes apoptosis of pancreatic cancer cells. Bioscience reports, 2022, 03-31, Volume: 42, Issue:3 Topics: Adenosine Triphosphate; Alanine; Amino Acid Transport System ASC; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cysteine; Glutamine; Humans; Minor Histocompatibility Antigens; Pancreas; Pancreatic Neoplasms; Reactive Oxygen Species; Serine	2022
Dual Inhibitions on Glucose/Glutamine Metabolisms for Nontoxic Pancreatic Cancer Therapy. ACS applied materials & interfaces, 2022, May-18, Volume: 14, Issue:19 Topics: Animals; Cell Proliferation; Glucose; Glutamine; Humans; Mammals; Pancreatic Neoplasms; Proto-Oncogene Proteins p21(ras); RNA, Small Interfering	2022
SNAT7 regulates mTORC1 via macropinocytosis. Proceedings of the National Academy of Sciences of the United States of America, 2022, 05-17, Volume: 119, Issue:20 Topics: Amino Acid Transport Systems, Neutral; Asparagine; Glutamine; Humans; Lysosomes; Mechanistic Target of Rapamycin Complex 1; Pancreatic Neoplasms; Pinocytosis; Signal Transduction	2022
Lysosomal lipid switch sensitises to nutrient deprivation and mTOR targeting in pancreatic cancer. Gut, 2023, Volume: 72, Issue:2 Topics: Animals; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Proliferation; Everolimus; Glutaminase; Glutamine; Lipids; Lysosomes; Mechanistic Target of Rapamycin Complex 1; Mice; MTOR Inhibitors; Nutrients; Pancreatic Neoplasms; Phosphatidylinositol 3-Kinases; Signal Transduction; TOR Serine-Threonine Kinases	2023
Loss of Heterozygosity for International journal of molecular sciences, 2022, Jun-15, Volume: 23, Issue:12 Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Proliferation; Glutamine; Humans; Hypoxia; Loss of Heterozygosity; Mice; Pancreatic Neoplasms; Phenotype; Proto-Oncogene Proteins c-myc; Proto-Oncogene Proteins p21(ras)	2022
Riluzole regulates pancreatic cancer cell metabolism by suppressing the Wnt-β-catenin pathway. Scientific reports, 2022, 06-30, Volume: 12, Issue:1 Topics: Animals; beta Catenin; Cell Line, Tumor; Cell Proliferation; Glutamine; Mice; Pancreatic Neoplasms; Riluzole; Wnt Signaling Pathway	2022
O-GlcNAcylation promotes pancreatic tumor growth by regulating malate dehydrogenase 1. Nature chemical biology, 2022, Volume: 18, Issue:10 Topics: Acetylglucosamine; Animals; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Glutamine; Malate Dehydrogenase; Mice; Mice, Nude; N-Acetylglucosaminyltransferases; Pancreatic Neoplasms; Proto-Oncogene Proteins p21(ras); Serine	2022
Cryptotanshinone suppresses tumorigenesis by inhibiting lipogenesis and promoting reactive oxygen species production in KRAS‑activated pancreatic cancer cells. International journal of oncology, 2022, Volume: 61, Issue:3 Topics: Carcinogenesis; Cell Line, Tumor; Cell Transformation, Neoplastic; Colorectal Neoplasms; Glutamine; Humans; Lipids; Lipogenesis; Pancreatic Neoplasms; Phenanthrenes; Proto-Oncogene Proteins p21(ras); Reactive Oxygen Species; Signal Transduction	2022
Cancer-associated fibroblasts employ NUFIP1-dependent autophagy to secrete nucleosides and support pancreatic tumor growth. Nature cancer, 2022, Volume: 3, Issue:8 Topics: Animals; Autophagy; Cancer-Associated Fibroblasts; Carcinoma, Pancreatic Ductal; Cell Proliferation; Glucose; Glutamine; Mice; Nuclear Proteins; Nucleosides; Pancreatic Hormones; Pancreatic Neoplasms; RNA-Binding Proteins; Tumor Microenvironment	2022
Phosphomimetic Dicer S1016E triggers a switch to glutamine metabolism in gemcitabine-resistant pancreatic cancer. Molecular metabolism, 2022, Volume: 65 Topics: Antimetabolites, Antineoplastic; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; DEAD-box RNA Helicases; Deoxycytidine; Drug Resistance, Neoplasm; Gemcitabine; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Humans; MicroRNAs; Pancreatic Neoplasms; Ribonuclease III; RNA, Small Interfering	2022
Pancreatic stellate cells exploit Wnt/β-catenin/TCF7-mediated glutamine metabolism to promote pancreatic cancer cells growth. Cancer letters, 2023, Feb-28, Volume: 555 Topics: beta Catenin; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Glutamine; Humans; Pancreatic Neoplasms; Pancreatic Stellate Cells; T Cell Transcription Factor 1	2023
Enhanced Glutaminolysis Drives Hypoxia-Induced Chemoresistance in Pancreatic Cancer. Cancer research, 2023, 03-02, Volume: 83, Issue:5 Topics: Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Proliferation; Deoxycytidine; Drug Resistance, Neoplasm; Gemcitabine; Glutamine; Humans; Hypoxia; Pancreatic Neoplasms	2023
M2 macrophage-derived exosomal miR-193b-3p promotes progression and glutamine uptake of pancreatic cancer by targeting TRIM62. Biology direct, 2023, 01-11, Volume: 18, Issue:1 Topics: Cell Line, Tumor; Cell Proliferation; Exosomes; Glutamine; Humans; Macrophages; MicroRNAs; Pancreatic Neoplasms; Tumor Microenvironment	2023
MYC/Glutamine Dependency Is a Therapeutic Vulnerability in Pancreatic Cancer with Deoxycytidine Kinase Inactivation-Induced Gemcitabine Resistance. Molecular cancer research : MCR, 2023, 05-01, Volume: 21, Issue:5 Topics: Antimetabolites, Antineoplastic; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Deoxycytidine; Deoxycytidine Kinase; Drug Resistance, Neoplasm; Gemcitabine; Glutamine; Humans; Pancreatic Neoplasms	2023
Glutamine deprivation induces ferroptosis in pancreatic cancer cells. Acta biochimica et biophysica Sinica, 2023, Mar-20, Volume: 55, Issue:8 Topics: Apoptosis; Ferroptosis; Glutamine; Humans; Pancreatic Neoplasms; Reactive Oxygen Species	2023
L-asparaginase anti-tumor activity in pancreatic cancer is dependent on its glutaminase activity and resistance is mediated by glutamine synthetase. Experimental cell research, 2023, 05-15, Volume: 426, Issue:2 Topics: Asparaginase; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Humans; Pancreatic Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma	2023
Pancreatic Cancer Is Dependent on De Novo Ornithine Synthesis from Glutamine. Cancer discovery, 2023, 06-02, Volume: 13, Issue:6 Topics: Arginine; Glutamine; Humans; Ornithine; Pancreas; Pancreatic Neoplasms	2023
The combination of immunotherapy and a glutamine metabolism inhibitor represents an effective therapeutic strategy for advanced and metastatic murine pancreatic adenocarcinoma. International immunopharmacology, 2023, Volume: 118 Topics: Adenocarcinoma; Animals; Cell Line, Tumor; Glutamine; Immunotherapy; Mice; Pancreatic Neoplasms	2023
An unexpected pathway to polyamines in pancreatic cancer. Molecular cell, 2023, 06-01, Volume: 83, Issue:11 Topics: Arginine; Glutamine; Humans; Pancreatic Neoplasms; Polyamines	2023
Metabolic stress-induced reciprocal loop of long noncoding RNA ZFAS1 and ZEB1 promotes epithelial-mesenchymal transition and metastasis of pancreatic cancer cells. Cancer science, 2023, Volume: 114, Issue:9 Topics: Animals; Cell Line, Tumor; Cell Proliferation; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Glutamine; Mice; Mice, Nude; MicroRNAs; Pancreatic Neoplasms; RNA, Long Noncoding; Zinc Finger E-box-Binding Homeobox 1	2023
miR-122-5p Restrains Pancreatic Cancer Cell Growth and Causes Apoptosis by Negatively Regulating ASCT2. Anticancer research, 2023, Volume: 43, Issue:10 Topics: Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic; Gene Expression Regulation, Neoplastic; Glutamine; Humans; Ketoglutaric Acids; MicroRNAs; Pancreatic Neoplasms	2023
SLC38A5 Modulates Ferroptosis to Overcome Gemcitabine Resistance in Pancreatic Cancer. Cells, 2023, 10-23, Volume: 12, Issue:20 Topics: Amino Acid Transport Systems, Neutral; Animals; Cell Line, Tumor; Deoxycytidine; Drug Resistance, Neoplasm; Ferroptosis; Gemcitabine; Glutamine; Humans; Mice; Pancreatic Neoplasms	2023
Aspulvinone O, a natural inhibitor of GOT1 suppresses pancreatic ductal adenocarcinoma cells growth by interfering glutamine metabolism. Cell communication and signaling : CCS, 2019, 08-30, Volume: 17, Issue:1 Topics: Adenocarcinoma; Antineoplastic Agents; Aspartate Aminotransferases; Cell Line, Tumor; Cell Proliferation; Enzyme Inhibitors; Furans; Glutamine; Humans; Molecular Docking Simulation; Pancreatic Neoplasms; Protein Conformation; Reactive Oxygen Species	2019
Glutamine Anabolism Plays a Critical Role in Pancreatic Cancer by Coupling Carbon and Nitrogen Metabolism. Cell reports, 2019, 10-29, Volume: 29, Issue:5 Topics: Animals; Carbon; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Proliferation; Female; Gene Deletion; Glutamate-Ammonia Ligase; Glutamine; Humans; Ketoglutaric Acids; Male; Mice, Inbred C57BL; Nitrogen; Pancreatic Neoplasms	2019
Deciphering cellular heterogeneity of pancreatic tumours. Nature cell biology, 2019, Volume: 21, Issue:11 Topics: Glutamine; Humans; Neoplastic Stem Cells; Pancreas; Pancreatic Neoplasms	2019
CD9 identifies pancreatic cancer stem cells and modulates glutamine metabolism to fuel tumour growth. Nature cell biology, 2019, Volume: 21, Issue:11 Topics: Amino Acid Transport System ASC; Animals; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Movement; Cell Proliferation; Gene Expression Regulation, Neoplastic; Glutamine; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Minor Histocompatibility Antigens; Neoplastic Stem Cells; Organoids; Pancreas; Pancreatic Neoplasms; Signal Transduction; Survival Analysis; Tetraspanin 29; Xenograft Model Antitumor Assays	2019
Undermining Glutaminolysis Bolsters Chemotherapy While NRF2 Promotes Chemoresistance in KRAS-Driven Pancreatic Cancers. Cancer research, 2020, 04-15, Volume: 80, Issue:8 Topics: Animals; Antimetabolites, Antineoplastic; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Deoxycytidine; Drug Resistance, Neoplasm; Gemcitabine; Glutaminase; Glutamine; Heterografts; Humans; Mice; Mice, Nude; Mutation; Neoplasm Proteins; NF-E2-Related Factor 2; Pancreatic Neoplasms; Prognosis; Proto-Oncogene Proteins p21(ras); Random Allocation; Tissue Array Analysis; Up-Regulation	2020
Loss of heterozygosity for Kras Biochemical and biophysical research communications, 2020, 06-11, Volume: 526, Issue:4 Topics: Adenocarcinoma; Apoptosis; Carcinoma, Pancreatic Ductal; Cell Cycle; Cell Hypoxia; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Progression; Gene Knockdown Techniques; Glutamine; Humans; Loss of Heterozygosity; Mutation; Neoplasm Invasiveness; Pancreatic Neoplasms; Proto-Oncogene Proteins p21(ras); Transcription Factors	2020
Glutamine depletion regulates Slug to promote EMT and metastasis in pancreatic cancer. The Journal of experimental medicine, 2020, 09-07, Volume: 217, Issue:9 Topics: Activating Transcription Factor 4; Adenocarcinoma; Animals; Biomarkers, Tumor; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Movement; Cell Survival; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Glutamine; HEK293 Cells; Humans; MAP Kinase Signaling System; Mice, Inbred C57BL; Neoplasm Metastasis; Pancreatic Neoplasms; RNA, Messenger; Snail Family Transcription Factors; Stress, Physiological	2020
Pancreatic cancer SLUGged. The Journal of experimental medicine, 2020, 09-07, Volume: 217, Issue:9 Topics: Animals; Cell Line, Tumor; Epithelial-Mesenchymal Transition; Gastropoda; Glutamine; Pancreatic Neoplasms	2020
Metabolic regulation of EGFR effector and feedback signaling in pancreatic cancer cells requires K-Ras. Biochemical and biophysical research communications, 2020, 12-10, Volume: 533, Issue:3 Topics: Carcinoma, Pancreatic Ductal; Cell Line, Tumor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Feedback, Physiological; Glutamine; Heparin-binding EGF-like Growth Factor; Humans; MAP Kinase Signaling System; Pancreatic Neoplasms; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins p21(ras)	2020
Rac1 and EGFR cooperate to activate Pak in response to nutrient stress. Biochemical and biophysical research communications, 2020, 12-10, Volume: 533, Issue:3 Topics: Carcinoma, Pancreatic Ductal; Enzyme Activation; ErbB Receptors; Glutamine; Humans; Isoenzymes; Nutrients; p21-Activated Kinases; Pancreatic Neoplasms; Phosphorylation; rac1 GTP-Binding Protein; Signal Transduction; Stress, Physiological; Tumor Cells, Cultured	2020
Novel Liver X Receptor Ligand GAC0001E5 Disrupts Glutamine Metabolism and Induces Oxidative Stress in Pancreatic Cancer Cells. International journal of molecular sciences, 2020, Dec-17, Volume: 21, Issue:24 Topics: Benzoates; Benzylamines; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation, Neoplastic; Glutamine; Humans; Ligands; Liver X Receptors; Oxidative Stress; Pancreatic Neoplasms; Reactive Oxygen Species; Signal Transduction; Transcription Factors; Transcriptome	2020
Circ-MBOAT2 knockdown represses tumor progression and glutamine catabolism by miR-433-3p/GOT1 axis in pancreatic cancer. Journal of experimental & clinical cancer research : CR, 2021, Apr-08, Volume: 40, Issue:1 Topics: 1-Acylglycerol-3-Phosphate O-Acyltransferase; Cell Proliferation; Glutamine; Humans; MicroRNAs; Pancreatic Neoplasms; RNA, Circular; Transfection	2021
SUCLA2-coupled regulation of GLS succinylation and activity counteracts oxidative stress in tumor cells. Molecular cell, 2021, 06-03, Volume: 81, Issue:11 Topics: Animals; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation, Neoplastic; Glutaminase; Glutamine; Glutathione; Heterografts; Humans; Male; Mice; Mice, Nude; NADP; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Pancreatic Neoplasms; Phosphorylation; Prognosis; Protein Processing, Post-Translational; Signal Transduction; Succinate-CoA Ligases; Succinic Acid; Survival Analysis	2021
GOT1-mediated anaplerotic glutamine metabolism regulates chronic acidosis stress in pancreatic cancer cells. Cancer letters, 2017, 08-01, Volume: 400 Topics: Acidosis; Aspartate Aminotransferase, Cytoplasmic; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Proliferation; Energy Metabolism; Glucose; Glutamine; Glycolysis; Humans; Hydrogen-Ion Concentration; Metabolomics; Oxaloacetic Acid; Oxidation-Reduction; Oxidative Phosphorylation; Oxidative Stress; Pancreatic Neoplasms; Reactive Oxygen Species; RNA Interference; Stress, Physiological; Time Factors; Transfection; Tumor Hypoxia; Tumor Microenvironment	2017
HIF-2α regulates non-canonical glutamine metabolism via activation of PI3K/mTORC2 pathway in human pancreatic ductal adenocarcinoma. Journal of cellular and molecular medicine, 2017, Volume: 21, Issue:11 Topics: Aged; Animals; Aspartate Aminotransferase, Cytoplasmic; Basic Helix-Loop-Helix Transcription Factors; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Movement; Cell Proliferation; Female; Gene Expression Regulation, Neoplastic; Glutamine; Humans; Lymphatic Metastasis; Male; Mechanistic Target of Rapamycin Complex 2; Mice, Nude; Middle Aged; Neoplasm Staging; Neoplasm Transplantation; Pancreatic Neoplasms; Phosphatidylinositol 3-Kinases; RNA, Small Interfering; Signal Transduction; Survival Analysis	2017
Compensatory metabolic networks in pancreatic cancers upon perturbation of glutamine metabolism. Nature communications, 2017, 07-03, Volume: 8 Topics: Animals; Cell Line, Tumor; Cell Proliferation; Female; Glutaminase; Glutamine; Humans; Male; Metabolic Networks and Pathways; Mice; Mice, Inbred C57BL; Pancreatic Neoplasms; Proteomics; Xenograft Model Antitumor Assays	2017
Disrupting glutamine metabolic pathways to sensitize gemcitabine-resistant pancreatic cancer. Scientific reports, 2017, 08-11, Volume: 7, Issue:1 Topics: Cell Line, Tumor; Cell Proliferation; Cell Survival; Deoxycytidine; Diazooxonorleucine; Drug Resistance, Neoplasm; Drug Synergism; Gemcitabine; Glutamine; Humans; Metabolic Networks and Pathways; Oxidation-Reduction; Pancreatic Neoplasms; Proteomics	2017
Glucose Limitation Alters Glutamine Metabolism in MUC1-Overexpressing Pancreatic Cancer Cells. Journal of proteome research, 2017, 10-06, Volume: 16, Issue:10 Topics: Aspartic Acid; Cell Line, Tumor; Cell Proliferation; Citric Acid Cycle; DNA Replication; Glucose; Glutamine; Glycolysis; Humans; Magnetic Resonance Spectroscopy; Metabolomics; Mucin-1; Oxaloacetic Acid; Pancreatic Neoplasms	2017
Glucose feeds the TCA cycle via circulating lactate. Nature, 2017, 11-02, Volume: 551, Issue:7678 Topics: Animals; Blood Glucose; Brain; Carbon; Citric Acid Cycle; Fasting; Glucose; Glutamine; Glycolysis; Lactic Acid; Mice; Muscles; Pancreatic Neoplasms	2017
KRAS Oncoprotein Expression Is Regulated by a Self-Governing eIF5A-PEAK1 Feed-Forward Regulatory Loop. Cancer research, 2018, 03-15, Volume: 78, Issue:6 Topics: Animals; Carcinoma, Pancreatic Ductal; Eukaryotic Translation Initiation Factor 5A; Feedback, Physiological; Female; Glutamine; GTP Phosphohydrolases; Humans; Lysine; Membrane Proteins; Mice, Nude; Pancreatic Neoplasms; Peptide Initiation Factors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins p21(ras); RNA-Binding Proteins; Signal Transduction; Xenograft Model Antitumor Assays	2018
Mitochondrial glutamine metabolism via GOT2 supports pancreatic cancer growth through senescence inhibition. Cell death & disease, 2018, 01-19, Volume: 9, Issue:2 Topics: Aspartate Aminotransferases; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Proliferation; Cellular Senescence; Glutamine; HEK293 Cells; Humans; Mitochondria; Pancreatic Neoplasms	2018
Palmatine suppresses glutamine-mediated interaction between pancreatic cancer and stellate cells through simultaneous inhibition of survivin and COL1A1. Cancer letters, 2018, 04-10, Volume: 419 Topics: Apoptosis; Berberine Alkaloids; Cell Communication; Cell Line, Tumor; Cell Movement; Cell Proliferation; Collagen Type I; Collagen Type I, alpha 1 Chain; Glutamine; Humans; Pancreatic Neoplasms; Pancreatic Stellate Cells; Signal Transduction; Survivin; Tumor Microenvironment	2018
Evaluating the Metabolic Alterations in Pancreatic Cancer. Methods in molecular biology (Clifton, N.J.), 2019, Volume: 1882 Topics: Adenosine Triphosphate; Cell Culture Techniques; Cell Line, Tumor; Cell Proliferation; Glucose; Glutamine; Glycolysis; Humans; Metabolomics; Mitochondria; Oxygen Consumption; Pancreas; Pancreatic Neoplasms; Reactive Oxygen Species	2019
Glutamine Deprivation Enhances Acetyl-CoA Carboxylase Inhibitor-induced Death of Human Pancreatic Cancer Cells. Anticancer research, 2018, Volume: 38, Issue:12 Topics: Acetyl-CoA Carboxylase; Apoptosis; Cell Death; Cell Line, Tumor; Drug Interactions; Drug Resistance, Neoplasm; Enzyme Inhibitors; Glutamine; Humans; Pancreatic Neoplasms	2018
Exocrine pancreatic and enterocyte function in patients with advanced pancreatic cancer. Clinical nutrition (Edinburgh, Scotland), 2019, Volume: 38, Issue:6 Topics: Aged; Citrulline; Enterocytes; Exocrine Pancreatic Insufficiency; Fats; Feces; Female; Glutamine; Humans; Intestinal Absorption; Male; Middle Aged; Pancreas; Pancreatic Neoplasms; Prospective Studies	2019
miR-9-5p inhibits pancreatic cancer cell proliferation, invasion and glutamine metabolism by targeting GOT1. Biochemical and biophysical research communications, 2019, 01-29, Volume: 509, Issue:1 Topics: 3' Untranslated Regions; Aspartate Aminotransferase, Cytoplasmic; Cell Line, Tumor; Cell Proliferation; Disease Progression; Down-Regulation; Gene Expression Regulation, Neoplastic; Glutamine; Humans; MicroRNAs; Neoplasm Invasiveness; Oxidation-Reduction; Pancreatic Neoplasms; RNA, Messenger	2019
Phellodendrine chloride suppresses proliferation of KRAS mutated pancreatic cancer cells through inhibition of nutrients uptake via macropinocytosis. European journal of pharmacology, 2019, May-05, Volume: 850 Topics: Animals; Apoptosis; Caspases; Cell Line, Tumor; Cell Proliferation; Cell Survival; Glutamine; Humans; Intracellular Space; Male; Membrane Potential, Mitochondrial; Mice; Mitochondria; Mutation; Nutrients; Pancreatic Neoplasms; Pinocytosis; Proto-Oncogene Proteins p21(ras); Quinolizines; Reactive Oxygen Species; Xenograft Model Antitumor Assays	2019
MiR-135 suppresses glycolysis and promotes pancreatic cancer cell adaptation to metabolic stress by targeting phosphofructokinase-1. Nature communications, 2019, 02-18, Volume: 10, Issue:1 Topics: Animals; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Survival; Gene Expression Regulation, Neoplastic; Glutamine; Glycolysis; Humans; Male; Mice, Nude; MicroRNAs; Pancreatic Neoplasms; Phosphofructokinase-1, Type C; Stress, Physiological; Xenograft Model Antitumor Assays	2019
Search for Early Pancreatic Cancer Blood Biomarkers in Five European Prospective Population Biobanks Using Metabolomics. Endocrinology, 2019, 07-01, Volume: 160, Issue:7 Topics: Aged; Biological Specimen Banks; Biomarkers, Tumor; Case-Control Studies; Early Diagnosis; Europe; Female; Glutamine; Histidine; Humans; Magnetic Resonance Spectroscopy; Male; Metabolomics; Middle Aged; Pancreatic Neoplasms	2019
Labeling Cancer Stem Cells with Methods in molecular biology (Clifton, N.J.), 2019, Volume: 1996 Topics: Animals; Antineoplastic Agents; Carbon Isotopes; Cell Hypoxia; Cell Line, Tumor; Cell Separation; Disease Models, Animal; Glucose; Glutamine; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Isotope Labeling; Metabolic Flux Analysis; Metabolic Networks and Pathways; Metabolomics; Mice; Neoplastic Stem Cells; Pancreatic Neoplasms; Single-Cell Analysis	2019
Upregulation of the Glutaminase II Pathway Contributes to Glutamate Production upon Glutaminase 1 Inhibition in Pancreatic Cancer. Proteomics, 2019, Volume: 19, Issue:21-22 Topics: Cell Line, Tumor; Cell Proliferation; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Glutamic Acid; Glutaminase; Glutamine; Humans; Lyases; Metabolic Networks and Pathways; Pancreatic Neoplasms; Transaminases	2019
EGFR-Pak Signaling Selectively Regulates Glutamine Deprivation-Induced Macropinocytosis. Developmental cell, 2019, 08-05, Volume: 50, Issue:3 Topics: Animals; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; ErbB Receptors; Female; Glutamine; Humans; Lysosomes; Mice; Mice, Nude; p21-Activated Kinases; Pancreatic Neoplasms; Pinocytosis; Signal Transduction	2019
Strengthened glycolysis under hypoxia supports tumor symbiosis and hexosamine biosynthesis in pancreatic adenocarcinoma. Proceedings of the National Academy of Sciences of the United States of America, 2013, Mar-05, Volume: 110, Issue:10 Topics: Animals; Carcinoma, Pancreatic Ductal; Cell Hypoxia; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Glutamine; Glycolysis; Hexosamines; Humans; Hypoxia; Lactic Acid; Male; Metabolic Networks and Pathways; Mice; Mice, Nude; Mice, Transgenic; Models, Biological; Pancreatic Neoplasms; Transplantation, Heterologous	2013
Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway. Nature, 2013, Apr-04, Volume: 496, Issue:7443 Topics: Adenocarcinoma; Aspartate Aminotransferases; Cell Line, Tumor; Cell Proliferation; Citric Acid Cycle; Glutamate Dehydrogenase; Glutamine; Homeostasis; Humans; Ketoglutaric Acids; Metabolic Networks and Pathways; Oncogene Protein p21(ras); Oncogenes; Oxidation-Reduction; Pancreatic Neoplasms; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); ras Proteins; Reactive Oxygen Species	2013
Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells. Nature, 2013, May-30, Volume: 497, Issue:7451 Topics: Amino Acids; Animals; Biological Transport; Carbon; Cell Line, Transformed; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Disease Models, Animal; Female; Glutamine; Mice; Mice, Nude; NIH 3T3 Cells; Oncogene Protein p21(ras); Pancreatic Neoplasms; Pinocytosis; Proteolysis	2013
Cancer metabolism in breadth and depth. Nature biotechnology, 2013, Volume: 31, Issue:6 Topics: Animals; Benzeneacetamides; Cell Differentiation; Cell Transformation, Neoplastic; Enzyme Inhibitors; Glioma; Glutamine; Hematopoiesis; Humans; Imidazoles; Isocitrate Dehydrogenase; Leukemia, Myeloid, Acute; Metabolic Networks and Pathways; Neoplasms; Oncogene Protein p21(ras); Pancreatic Neoplasms; Phenylurea Compounds; Proto-Oncogene Proteins; ras Proteins; Sulfonamides	2013
Pancreatic cancers rely on a novel glutamine metabolism pathway to maintain redox balance. Cell cycle (Georgetown, Tex.), 2013, Jul-01, Volume: 12, Issue:13 Topics: Cell Proliferation; Glutamine; Humans; Metabolic Networks and Pathways; NADP; Oxidation-Reduction; Pancreatic Neoplasms	2013
Cannabinoids inhibit energetic metabolism and induce AMPK-dependent autophagy in pancreatic cancer cells. Cell death & disease, 2013, Jun-13, Volume: 4 Topics: Acetylcysteine; Adenocarcinoma; Adenosine Monophosphate; Adenosine Triphosphate; Adenylate Kinase; Antineoplastic Agents; Arachidonic Acids; Autophagy; Cannabinoids; Cell Line, Tumor; Cell Nucleus; Citric Acid Cycle; Drug Screening Assays, Antitumor; Energy Metabolism; Enzyme Activation; Glutamine; Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating); Glycolysis; Humans; Indoles; Morpholines; Pancreatic Neoplasms; Reactive Oxygen Species; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2	2013
Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein. Cancer research, 2015, Feb-01, Volume: 75, Issue:3 Topics: Albumins; Amino Acids; Animals; Carcinoma, Pancreatic Ductal; Cell Proliferation; Chromatography, Liquid; Gene Expression Regulation, Neoplastic; Glucose; Glutamine; Humans; Mass Spectrometry; Mice; Pancreatic Neoplasms; Pinocytosis; Serine; Signal Transduction; Stem Cells; Tumor Cells, Cultured	2015
Metabolic phenotypes in pancreatic cancer. PloS one, 2015, Volume: 10, Issue:2 Topics: Adult; Aged; Antigens, Neoplasm; Apoptosis Regulatory Proteins; Beclin-1; Carbonic Anhydrase IX; Carbonic Anhydrases; Female; Glucose; Glucose Transporter Type 1; Glutamate Dehydrogenase; Glutamine; Humans; Immunohistochemistry; Lymphatic Metastasis; Male; Membrane Proteins; Microtubule-Associated Proteins; Middle Aged; Pancreatic Neoplasms; Phenotype; Prognosis; Proportional Hazards Models; Proto-Oncogene Proteins; RNA-Binding Proteins; Survival Analysis	2015
Inhibition of glutamine metabolism counteracts pancreatic cancer stem cell features and sensitizes cells to radiotherapy. Oncotarget, 2015, Oct-13, Volume: 6, Issue:31 Topics: Animals; Apoptosis; Aspartate Aminotransferases; Blotting, Western; Cell Proliferation; Flow Cytometry; Gamma Rays; Glutamate Dehydrogenase; Glutamine; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplastic Stem Cells; Pancreatic Neoplasms; Radiation Tolerance; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Tumor Cells, Cultured; Xenograft Model Antitumor Assays	2015
Metabolic Symbiosis Enables Adaptive Resistance to Anti-angiogenic Therapy that Is Dependent on mTOR Signaling. Cell reports, 2016, 05-10, Volume: 15, Issue:6 Topics: Angiogenesis Inhibitors; Animals; Axitinib; Cell Line, Tumor; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Glucose; Glutamine; Glycolysis; Humans; Imidazoles; Indazoles; Indoles; Intestinal Neoplasms; Lactic Acid; Membrane Transport Proteins; Mice; Models, Biological; Neuroendocrine Tumors; Pancreatic Neoplasms; Pyrroles; Signal Transduction; Sirolimus; Stomach Neoplasms; Sunitinib; TOR Serine-Threonine Kinases; Up-Regulation	2016
Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer. Proceedings of the National Academy of Sciences of the United States of America, 2016, 09-06, Volume: 113, Issue:36 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Benzeneacetamides; Cell Line, Tumor; Glutaminase; Glutamine; Humans; Metformin; Mice; Nanoparticles; Pancreatic Neoplasms; Proto-Oncogene Proteins p21(ras); Sulfides; Thiadiazoles; Xenograft Model Antitumor Assays	2016
Unique metabolic features of pancreatic cancer stroma: relevance to the tumor compartment, prognosis, and invasive potential. Oncotarget, 2016, Nov-29, Volume: 7, Issue:48 Topics: Animals; Antigens, Neoplasm; Cancer-Associated Fibroblasts; Carbonic Anhydrase IX; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Movement; Cell Proliferation; Energy Metabolism; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Glucose; Glutamine; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Kaplan-Meier Estimate; Mice; Monocarboxylic Acid Transporters; Muscle Proteins; Neoplasm Invasiveness; Pancreatic Neoplasms; Phenotype; Proportional Hazards Models; RNA Interference; Stromal Cells; Time Factors; Transcription, Genetic; Transfection; Tumor Hypoxia; Tumor Microenvironment	2016
Arginine Methylation of MDH1 by CARM1 Inhibits Glutamine Metabolism and Suppresses Pancreatic Cancer. Molecular cell, 2016, 11-17, Volume: 64, Issue:4 Topics: Arginine; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation, Neoplastic; Glutamine; HEK293 Cells; Humans; Malate Dehydrogenase (NADP+); Methylation; Mitochondria; Models, Molecular; NADP; Oxidation-Reduction; Pancreatic Neoplasms; Protein Multimerization; Protein Structure, Secondary; Protein-Arginine N-Methyltransferases; RNA, Small Interfering; Signal Transduction	2016
Analysis of hydrophilic metabolites in physiological fluids by HPLC-MS using a silica hydride-based stationary phase. Journal of separation science, 2009, Volume: 32, Issue:13 Topics: Chromatography, High Pressure Liquid; Creatinine; Glucose; Glutamine; Humans; Hydrophobic and Hydrophilic Interactions; Lysine; Mass Spectrometry; Pancreatic Neoplasms; Pancreatitis; Saliva; Silicates; Urine	2009
Proteomic analysis reveals Warburg effect and anomalous metabolism of glutamine in pancreatic cancer cells. Journal of proteome research, 2012, Feb-03, Volume: 11, Issue:2 Topics: Carcinoma, Pancreatic Ductal; Case-Control Studies; Cell Line, Tumor; Chromatography, Liquid; Down-Regulation; Glutamine; Humans; Metabolic Networks and Pathways; Pancreatic Neoplasms; Proteome; Proteomics; Tandem Mass Spectrometry; Up-Regulation	2012
Metabolite detection of pancreatic carcinoma by in vivo proton MR spectroscopy at 3T: initial results. La Radiologia medica, 2012, Volume: 117, Issue:5 Topics: Adult; Aged; Aspartic Acid; Biomarkers, Tumor; Choline; Dipeptides; Fatty Acids, Unsaturated; Female; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Pancreatic Neoplasms; Software	2012
MUC1 mucin stabilizes and activates hypoxia-inducible factor 1 alpha to regulate metabolism in pancreatic cancer. Proceedings of the National Academy of Sciences of the United States of America, 2012, Aug-21, Volume: 109, Issue:34 Topics: Animals; Female; Gene Expression Regulation, Neoplastic; Glucose; Glutamine; Glycolysis; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Ketoglutaric Acids; Mice; Mice, Nude; Models, Biological; Mucin-1; p300-CBP Transcription Factors; Pancreatic Neoplasms; Pentose Phosphate Pathway; Promoter Regions, Genetic; Signal Transduction	2012
Effect of low glutamine/glucose on hypoxia-induced elevation of hypoxia-inducible factor-1alpha in human pancreatic cancer MiaPaCa-2 and human prostatic cancer DU-145 cells. Clinical cancer research : an official journal of the American Association for Cancer Research, 2005, Jul-01, Volume: 11, Issue:13 Topics: Blotting, Western; Cell Hypoxia; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Glucose; Glutamine; Humans; Male; Pancreatic Neoplasms; Prostatic Neoplasms; Proteasome Endopeptidase Complex; Protein Biosynthesis; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger	2005
The XPD Asp312Asn and Lys751Gln polymorphisms, corresponding haplotype, and pancreatic cancer risk. Cancer letters, 2007, Jan-08, Volume: 245, Issue:1-2 Topics: Adenocarcinoma; Aged; Amino Acid Substitution; Asparagine; Aspartic Acid; Carcinoma, Pancreatic Ductal; Case-Control Studies; Female; Gene Frequency; Genotype; Glutamine; Haplotypes; Humans; Linkage Disequilibrium; Lysine; Male; Middle Aged; Pancreatic Neoplasms; Polymorphism, Single Nucleotide; Risk Factors; Smoking; Xeroderma Pigmentosum Group D Protein	2007
L-leucine methyl ester stimulates insulin secretion and islet glutamate dehydrogenase. The American journal of physiology, 1983, Volume: 245, Issue:4 Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line; Glucagon; Glucose; Glutamate Dehydrogenase; Glutamine; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Kinetics; Leucine; Male; Mice; Mice, Inbred Strains; Norepinephrine; Pancreatic Neoplasms; Rats	1983
The glucose sensor protein glucokinase is expressed in glucagon-producing alpha-cells. Proceedings of the National Academy of Sciences of the United States of America, 1996, Jul-09, Volume: 93, Issue:14 Topics: 1-Methyl-3-isobutylxanthine; Animals; Base Sequence; Brain; Cells, Cultured; DNA Primers; DNA, Complementary; Glucagon; Glucagonoma; Glucokinase; Glucose; Glucose Transporter Type 2; Glutamine; Homeostasis; Insulin; Islets of Langerhans; Liver; Male; Molecular Sequence Data; Monosaccharide Transport Proteins; Pancreatic Neoplasms; Polymerase Chain Reaction; Rats; Rats, Wistar; RNA, Messenger; Transcription, Genetic; Tumor Cells, Cultured	1996
A nutrient-regulated cytosolic calcium oscillator in endocrine pancreatic glucagon-secreting cells. Pflugers Archiv : European journal of physiology, 1999, Volume: 437, Issue:3 Topics: Alanine; Animals; Calcium; Carbachol; Cricetinae; Cytosol; Energy Metabolism; Glucagon; Glucagonoma; Glucose; Glutamine; Homeostasis; Islets of Langerhans; Membrane Potentials; Muscarinic Agonists; Pancreatic Neoplasms; Periodicity; Sodium-Potassium-Exchanging ATPase; Tumor Cells, Cultured	1999
Unregulated elevation of glutamate dehydrogenase activity induces glutamine-stimulated insulin secretion: identification and characterization of a GLUD1 gene mutation and insulin secretion studies with MIN6 cells overexpressing the mutant glutamate dehydr Diabetes, 2002, Volume: 51, Issue:3 Topics: Adenosine Diphosphate; Animals; Blood Glucose; COS Cells; DNA Mutational Analysis; Female; Glucose; Glutamate Dehydrogenase; Glutamine; Guanosine Triphosphate; Humans; Hyperinsulinism; Hypoglycemia; Infant; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Mutation; Pancreatic Neoplasms; Polymerase Chain Reaction; Polymorphism, Single-Stranded Conformational; Transfection; Tumor Cells, Cultured	2002
Mechanism of sensitivity of cultured pancreatic carcinoma to asparaginase. International journal of cancer, 1978, Volume: 22, Issue:6 Topics: Amino Acids; Asparaginase; Asparagine; Breast Neoplasms; Cell Line; Cell Survival; Cells, Cultured; DNA, Neoplasm; Escherichia coli; Female; Glutamine; Glycoproteins; Humans; Melanoma; Neoplasm Proteins; Pancreatic Neoplasms; RNA, Neoplasm; Vibrio	1978
High serum glutamic acid levels in patients with carcinoma of the pancreas. Digestion, 1976, Volume: 14, Issue:4 Topics: Female; Glutamates; Glutamine; Humans; Male; Pancreatic Neoplasms	1976
Lorglumide and loxiglumide inhibit gastrin-stimulated DNA synthesis in a rat tumoral acinar pancreatic cell line (AR42J). Cancer research, 1990, Sep-15, Volume: 50, Issue:18 Topics: Animals; DNA, Neoplasm; Gastrins; Glutamine; Ornithine Decarboxylase; Pancreatic Neoplasms; Proglumide; Rats; Receptors, Cholecystokinin; Thymidine; Tumor Cells, Cultured	1990
Modulation by CR-1409 (lorglumide), a cholecystokinin receptor antagonist, of trypsin inhibitor-enhanced growth of azaserine-induced putative preneoplastic lesions in rat pancreas. Cancer research, 1989, May-01, Volume: 49, Issue:9 Topics: Animals; Azaserine; Cholecystokinin; Esters; Gabexate; Glutamine; Guanidines; Male; Pancreatic Neoplasms; Precancerous Conditions; Proglumide; Rats; Rats, Inbred Strains; Receptors, Cholecystokinin; Sincalide; Trypsin Inhibitors	1989
Availability of glutamine from peptides and acetylglutamine for human tumor-cell cultures. Metabolism: clinical and experimental, 1989, Volume: 38, Issue:8 Suppl 1 Topics: Breast Neoplasms; Cell Division; Dipeptides; DNA; Glutamine; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Neoplasms; Pancreatic Neoplasms; Stomach Neoplasms; Tumor Cells, Cultured	1989
Crabtree effect in tumoral pancreatic islet cells. The Journal of biological chemistry, 1988, Feb-05, Volume: 263, Issue:4 Topics: Adenine Nucleotides; Adenoma, Islet Cell; Animals; Glucose; Glutamine; Lactates; Lactic Acid; Lipids; NAD; NADP; Oxidation-Reduction; Oxygen Consumption; Palmitic Acid; Palmitic Acids; Pancreatic Neoplasms; Tumor Cells, Cultured	1988
Cellular toxicity of pancreatic carcinogens. Journal of the National Cancer Institute, 1986, Volume: 76, Issue:6 Topics: Animals; Azaserine; Carcinogens; Cricetinae; Glutamine; Leucine; Male; Mesocricetus; Nitrosamines; Pancreatic Neoplasms; Protein Biosynthesis; Rats; Rats, Inbred Strains; Streptozocin; Tritium	1986