Compounds > glutamine

glutamine and Hyperammonemia

glutamine has been researched along with Hyperammonemia in 99 studies

Research

Studies (99)

TimeframeStudies, this research(%)All Research%
pre-19902 (2.02)18.7374
1990's0 (0.00)18.2507
2000's39 (39.39)29.6817
2010's49 (49.49)24.3611
2020's9 (9.09)2.80

Authors

AuthorsStudies
Burczynski, ME; Chen, H; Cheng, X; Halasz, G; Kim, S; Lin, AZ; Mao, X; Murphy, AJ; Na, E; Okamoto, H; Sleeman, MW1
Arrieta, F; Belanger-Quintana, A; Del Valle, M; Fernandez-Felix, BM; Garcia, F; Martinez-Pardo, M; Ruiz-Sala, P; Stanescu, S1
Andersen, JV; Bak, LK; Dam, G; Ott, P; Schousboe, A; Sørensen, M; Vilstrup, H; Walls, AB1
Fukui, K; Ishihara, N; Kakuma, T; Matsunari, H; Nagashima, H; Takahashi, T; Uchikura, A; Watanabe, M; Watanabe, Y; Yamashita, Y; Yoshino, M1
Claeys, W; Geerts, A; Ghesquière, B; Lefere, S; Van Hoecke, L; Van Imschoot, G; Van Steenkiste, C; Van Vlierberghe, H; Van Wonterghem, E; Vandenbroucke, RE1
Altintas, B; Eldem, I; Langley, R; Lee, A; Nguyen, H; Shinawi, M; Willis, D1
Lichter-Konecki, U; McCarter, R; Sanz, JH1
Li, Y; Liu, XF; Lu, JJ; Qiang, JW; Yang, XY1
Allegri, G; Burke, KE; Cederbaum, SD; Häberle, J; Lipshutz, GS; Liu, XB; Martini, PGV; Truong, B; Zhu, X1
Danbolt, NC; Eid, T; Hassel, B; Zhou, Y1
Bellinger, A; Berry, GT; Cohen, DE; Frank, NY; Gershanik, EF; Goldberg, AD; Levy, BD; Lin, AP; Lynch, R; McFaline-Figueroa, JR; Merugumala, SK; O'Donnell-Luria, AH; Rohr, F; Samuels, MA; Simon, T; Tchekmedyian, V; Waisbren, SE1
Brioudes, E; Grimaldi, M; Karaca, M; Latini, L; Maechler, P; Schalch, T1
Bukofzer, S; Clasen, K; Durkalski, V; Fontana, RJ; Ganger, D; Gottfried, M; Hameed, B; Hanje, AJ; Koch, D; Lee, WM; Little, L; Ravis, WR; Sherker, A; Stravitz, RT; Subramanian, RM1
Albrecht, J; Dabrowska, K; Obara-Michlewska, M; Popek, M; Skowronska, K; Zielinska, M1
Akula, VP; Alcorn, D; Benitz, WE; Bernstein, JA; Berquist, WE; Blumenfeld, YJ; Castillo, RO; Concepcion, W; Cowan, TM; Cox, KL; Cusmano, K; Enns, GM; Esquivel, CO; Hintz, SR; Homeyer, M; Hudgins, L; Hurwitz, M; Lyell, DJ; Palma, JP; Schelley, S; Summar, ML; Wilnai, Y1
Borzone, R; Brunetti-Pierri, N; Hermann, K; Khoja, S; Lipshutz, GS; Ng, P; Nitzahn, M; Palmer, DJ; Rudd, M; Truong, B; Willis, B1
Holeček, M; Vodeničarovová, M1
Gaillard, WD; Gropman, AL; Massaro, A; Prust, M; Tsuchida, TN; Vezina, G; Wiwattanadittakul, N1
Arenas, YM; Cabrera-Pastor, A; Felipo, V; Montoliu, C; Taoro-Gonzalez, L1
Brunetti-Pierri, N; Soria, LR1
Allegri, G; Häberle, J; Khoja, S; Lambert, J; Lipshutz, GS; Nitzahn, M; Rüfenacht, V; Truong, B; Willis, B1
Albrecht, U; Bidmon, HJ; Bode, JG; Buschmann, T; Görg, B; Häussinger, D; Jin, CJ; Monhasery, N; Oenarto, J; Qvartskhava, N1
Alexeeva, O; Baranovsky, A; Bass, NM; Brown, RS; Coakley, D; Dickinson, K; Dudar, L; Fadieienko, G; Ghabril, M; Grewal, P; Grinevich, V; Kharchenko, N; Klaryts'ka, I; Mantry, P; McCashland, T; Mokhtarani, M; Morozov, V; Norris, C; Reddy, KG; Reddy, KR; Rockey, DC; Scharschmidt, BF; Syplyviy, V; Vierling, JM; Zupanets, IA1
Holecek, M2
Bode, J; Caballero, B; Gavish, M; Leschiner, S; Veenman, L1
Cooper, AJ; Kuhara, T1
Ott, P; Vilstrup, H1
Bartholomew, D; Bartley, JA; Berquist, W; Berry, SA; Cederbaum, S; Coakley, DF; Diaz, GA; Feigenbaum, A; Gallagher, R; Harding, CO; Korson, MS; Kronn, D; Le Mons, C; Lee, B; Lichter-Konecki, U; Longo, N; Marino, M; McCandless, SE; Merritt, JL; Milikien, DA; Mokhtarani, M; Nagamani, SC; Rhead, W; Scharschmidt, BF; Schulze, A; Smith, W; Summar, M; Vockley, G; Vockley, J; Wong, D; Zori, R1
Lu, GM; Su, YY; Wu, S; Yang, GF; Zhang, LJ1
Gautschi, M; Häberle, J; Hahn, D; Hu, L; Laemmle, A; Leibundgut, K; Nuoffer, JM; Rüfenacht, V1
Ben-Omran, T; Chaudhry, FA; Frapolli, M; Görg, B; Häberle, J; Häussinger, D; Hu, L; Ibrahim, K; Penberthy, WT; Shahbeck, N; Stucki, M1
Cioccari, L; Etter, R; Gautschi, M; Takala, J; Weck, A1
Cooper, AJ; Denton, TT; Deryabina, YI; Dorai, T; Isakova, EP; Krasnikov, BF; Pinto, JT; Shurubor, YI1
Bartley, J; Berquist, W; Berry, SA; Coakley, DF; Diaz, GA; Feigenbaum, A; Gallagher, RC; Harding, CO; Le Mons, C; Lee, B; Lichter-Konecki, U; Longo, N; Marino, M; McCandless, SE; Mokhtarani, M; Nagamani, SC; Rhead, W; Rowell, R; Scharschmidt, BF; Schulze, A; Smith, W1
Chen, Y; Hertz, L; Peng, L; Song, D1
Ramakrishnan, A; Renuka, M; Vijayakumar, N1
Mishra, R; Mishra, S1
Braissant, O; Cudalbu, C; Lanz, B; Rackayova, V1
Eichinger-Öttl, U; Ertl, C; Haberlandt, E; Häberle, J; Heinz-Erian, P; Karall, D; Rostásy, K; Scholl-Bürgi, S; Sigl, SB1
Galán, JJ; Jover, M; Romero-Gómez, M; Ruiz, A1
Dejong, CH; Jalan, R; Olde Damink, SW1
Smith, T; White, RP; Wong, SH1
Buechert, M; Garcia, M; Huppertz, HJ; Mader, I; Schumacher, M; Ziyeh, S1
Heins, J; Zwingmann, C1
Herebian, D; Laryea, MD; Mayatepek, E; Meissner, T1
Ivnitsky, JJ; Rejniuk, VL; Schäfer, TV1
Blamire, AM; Mardini, H; Record, CO; Smith, FE1
Aires, CC; de Almeida, IT; Duran, M; Ijlst, L; Silva, MF; van Cruchten, A; Wanders, RJ1
Ivnitsky, YY; Rejniuk, VL; Schäfer, TV1
Gupta, RK; Saraswat, VA; Srivastava, A; Thomas, MA; Yachha, SK; Yadav, SK1
Bernal, W; Bjerring, PN; Eefsen, M; Larsen, FS; Wendon, J1
Bak, LK; Dadsetan, S; Keiding, S; Leke, R; Ott, P; Schousboe, A; Sørensen, M; Vilstrup, H; Waagepetersen, HS1
Brusilow, SW; Cooper, AJ1
Cipriani, S; D'Amore, C; Distrutti, E; Fiorucci, S; Mencarelli, A; Monti, MC; Renga, B; Zampella, A1
Mhanni, AA; Prasad, C; Rockman-Greenberg, C1
Cudalbu, C; Duarte, JM; Gruetter, R; Lanz, B; Mlynárik, V; Morgenthaler, FD; Pilloud, Y1
Blanco Vela, CI; Poo Ramírez, JL1
Walker, V1
Bjerring, PN; Clemmesen, JO; Frederiksen, HJ; Hauerberg, J; Larsen, FS; Nielsen, HB1
Bak, LK; Dadsetan, S; Jalan, R; Keiding, S; Ott, P; Schousboe, A; Sørensen, M; Vilstrup, H; Waagepetersen, HS1
Ivnitsky, JJ; Malakhovsky, VN; Rejuniuk, VL; Schaefer, TV1
Mardini, H; Record, C1
Pérez-Pinzón, MA; Veauvy, CM; Walsh, PJ; Wang, Y1
Klisch, J; Schumacher, M; Spreer, J; Thiel, T; Ziyeh, S1
Balata, S; Deutz, NE; Ferguson, K; Hayes, PC; Jalan, R; Marshall, I; Olde Damink, SW; Wardlaw, J; Williams, R1
BERTHAUX, N; SCHWARZMANN, V1
Balata, S; Deutz, NE; Hayes, PC; Jalan, R; Marshall, I; Olde Damink, SW; Shawcross, DL; Wardlaw, J; Williams, R1
Bautista, JD; Grande, L; Ramos Guerrero, RM; Romero Gómez, M; Sánchez Muñoz, D1
Brusilow, SW; Traystman, R1
Hertz, L; Kala, G2
Leibfritz, D; Zwingmann, C1
Butterworth, R; Zwingmann, C1
Kanamori, K; Ross, BD2
Hansen, BA; Hauerberg, J; Jørgensen, L; Larsen, FS; Pedersen, CB; Tofteng, F1
Berger, R; Besley, GT; Cleary, MA; de Koning, TJ; Dorland, L; Duran, M; Mandell, R; Olpin, SE; Poll-The, BT; Shih, VE1
Ashurst, CL; Ernst, SL; Filipowicz, HR; Longo, N; Pasquali, M1
Garlick, PJ; Lee, B; Marini, JC1
Puente, V; Rodriguez-Campello, A; Roquer, J; Segura-Bruna, N1
Davies, NA; Deutz, NE; Hodges, S; Jalan, R; Nedredal, GI; Revhaug, A; Romero-Gomez, M; Rose, C; Sen, S; Ten Have, GA; Williams, R; Ytrebø, LM1
Albrecht, J; Schousboe, A; Sonnewald, U; Waagepetersen, HS1
Larsen, FS; Olsen, NV; Pedersen, HR; Ring-Larsen, H1
Au, WL; Lim, CC; Wong, YC; Xu, M; Ye, J1
Zwingmann, C2
Bodega, G; Fernández, B; Paniagua, C; Suárez, I; Vacas, E1
Clay, AS; Hainline, BE1
Butterworth, RF; Vaquero, J1
Bjerring, PN; Frederiksen, HJ; Hansen, BA; Hauerberg, J; Jorgensen, L; Larsen, FS; Tofteng, F1
Blanke, CD; Chan, JS; Harding, CO1
Albrecht, J; Dolińska, M; Lazarewicz, JW; Ziemińska, E1
Behar, KL; Cline, GW; Herskovits, AZ; Mason, GF; Rothman, DL; Shen, J; Shulman, RG; Sibson, NR; Wall, JE1
Behar, KL; Rothman, DL1
Bai, G; Murthy, CR; Norenberg, MD; Rama Rao, KV1
Abeni, D; Bartuli, A; Dionisi-Vici, C; Orzalesi, M; Pastore, A; Picca, S; Rizzo, C; Rizzoni, G; Sabetta, G1
Cooper, AJ1
Cawthon, DF; Caylor, LM; Kraemer, DL; Morgan, JD; Ojemann, LM; Vossler, DG; Wilensky, AJ1

Reviews

28 review(s) available for glutamine and Hyperammonemia

ArticleYear
Novel aspects of glutamine synthetase in ammonia homeostasis.
    Neurochemistry international, 2020, Volume: 140

    Topics: Ammonia; Animals; Brain; Brain Diseases; Glutamate-Ammonia Ligase; Glutamic Acid; Glutamine; Homeostasis; Humans; Hyperammonemia; Liver

2020
Roles of Glutamate and Glutamine Transport in Ammonia Neurotoxicity: State of the Art and Question Marks.
    Endocrine, metabolic & immune disorders drug targets, 2018, Volume: 18, Issue:4

    Topics: Amino Acid Transport System X-AG; Amino Acid Transport Systems; Amino Acid Transport Systems, Neutral; Ammonia; Animals; Astrocytes; Brain; Excitatory Amino Acid Transporter 2; Glutamic Acid; Glutamine; Hepatic Encephalopathy; Humans; Hyperammonemia; Kinetics; Mitochondria; Neurons

2018
Chronic hyperammonemia alters extracellular glutamate, glutamine and GABA and membrane expression of their transporters in rat cerebellum. Modulation by extracellular cGMP.
    Neuropharmacology, 2019, 12-15, Volume: 161

    Topics: Animals; Cell Membrane; Cerebellum; Citrulline; Cyclic GMP; Extracellular Space; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Hyperammonemia; Male; Neurotransmitter Transport Proteins; Rats; Rats, Wistar; Synaptic Transmission

2019
Ammonia and autophagy: An emerging relationship with implications for disorders with hyperammonemia.
    Journal of inherited metabolic disease, 2019, Volume: 42, Issue:6

    Topics: Ammonia; Animals; Autophagy; Glutamate-Ammonia Ligase; Glutamine; Homeostasis; Humans; Hyperammonemia; Liver; Urea; Urea Cycle Disorders, Inborn

2019
Evidence of a vicious cycle in glutamine synthesis and breakdown in pathogenesis of hepatic encephalopathy-therapeutic perspectives.
    Metabolic brain disease, 2014, Volume: 29, Issue:1

    Topics: Amino Acids, Branched-Chain; Ammonia; Brain; Critical Illness; Drug Interactions; Enterocytes; Glutamic Acid; Glutaminase; Glutamine; Hepatic Encephalopathy; Humans; Hyperammonemia; Intestines; Ketoglutaric Acids; Kidney; Liver; Microbiota; Muscle, Skeletal; Organ Specificity; Phenylbutyrates

2014
α-Ketoglutaramate: an overlooked metabolite of glutamine and a biomarker for hepatic encephalopathy and inborn errors of the urea cycle.
    Metabolic brain disease, 2014, Volume: 29, Issue:4

    Topics: Amidohydrolases; Aminohydrolases; Ammonia; Animals; Biomarkers; Carbon; Glutamine; Hepatic Encephalopathy; Humans; Hyperammonemia; Keto Acids; Ketoglutaric Acids; Kynurenine; Liver Diseases; Mammals; Methionine; Nitrogen; Sulfur; Transaminases; Urea Cycle Disorders, Inborn

2014
Cerebral effects of ammonia in liver disease: current hypotheses.
    Metabolic brain disease, 2014, Volume: 29, Issue:4

    Topics: Ammonia; Animals; Astrocytes; Blood-Brain Barrier; Brain Edema; Diffusion; Energy Metabolism; gamma-Aminobutyric Acid; Glutamine; Glycolysis; Hepatic Encephalopathy; Humans; Hyperammonemia; Ketoglutarate Dehydrogenase Complex; Lactates; Liver Diseases; Mitochondria; Models, Biological; Receptors, GABA; Receptors, Glutamate; Synaptic Transmission

2014
Ammonia and amino acid profiles in liver cirrhosis: effects of variables leading to hepatic encephalopathy.
    Nutrition (Burbank, Los Angeles County, Calif.), 2015, Volume: 31, Issue:1

    Topics: Amino Acids, Aromatic; Amino Acids, Branched-Chain; Ammonia; Brain; Dietary Proteins; Glutamine; Hepatic Encephalopathy; Humans; Hyperammonemia; Inflammation; Liver Cirrhosis; Muscle, Skeletal

2015
PET and MR imaging of neuroinflammation in hepatic encephalopathy.
    Metabolic brain disease, 2015, Volume: 30, Issue:1

    Topics: Amino Acid Transport System X-AG; Animals; Blood-Brain Barrier; Brain; Brain Edema; Cytokines; Disease Models, Animal; Glutamate-Ammonia Ligase; Glutamic Acid; Glutamine; Hepatic Encephalopathy; Hyperammonemia; Imidazoles; Inflammation; Isoquinolines; Magnetic Resonance Imaging; Microglia; Mitochondria; Multimodal Imaging; Neuroimaging; Portacaval Shunt, Surgical; Positron-Emission Tomography; Psychometrics; Pyrazoles; Pyrimidines; Rats

2015
ω-Amidase: an underappreciated, but important enzyme in L-glutamine and L-asparagine metabolism; relevance to sulfur and nitrogen metabolism, tumor biology and hyperammonemic diseases.
    Amino acids, 2016, Volume: 48, Issue:1

    Topics: Amidohydrolases; Animals; Asparagine; Glutamine; Humans; Hyperammonemia; Neoplasms; Nitrogen; Sulfur

2016
Multifactorial Effects on Different Types of Brain Cells Contribute to Ammonia Toxicity.
    Neurochemical research, 2017, Volume: 42, Issue:3

    Topics: Ammonia; Animals; Astrocytes; Brain; Cyclic GMP; Energy Metabolism; Glutamine; Hepatic Encephalopathy; Humans; Hyperammonemia; Lactic Acid; Liver Failure, Acute; Potassium; Pyruvic Acid; Sodium-Potassium-Exchanging ATPase; Solute Carrier Family 12, Member 2

2017
MRS studies of neuroenergetics and glutamate/glutamine exchange in rats: Extensions to hyperammonemic models.
    Analytical biochemistry, 2017, 07-15, Volume: 529

    Topics: Animals; Brain; Glutamic Acid; Glutamine; Hyperammonemia; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Models, Biological; Rats

2017
Gut ammonia production and its modulation.
    Metabolic brain disease, 2009, Volume: 24, Issue:1

    Topics: Ammonia; Animals; Genetic Predisposition to Disease; Glutaminase; Glutamine; Hepatic Encephalopathy; Humans; Hyperammonemia; Intestine, Small; Liver Circulation; Liver Failure, Acute; Mutation

2009
Interorgan ammonia trafficking in liver disease.
    Metabolic brain disease, 2009, Volume: 24, Issue:1

    Topics: Amino Acids; Ammonia; Animals; Brain; Glutamine; Humans; Hyperammonemia; Intestinal Mucosa; Intestines; Kidney; Liver Circulation; Liver Diseases; Muscle, Skeletal

2009
Organic osmolytes in hyponatremia and ammonia toxicity.
    Metabolic brain disease, 2010, Volume: 25, Issue:1

    Topics: Animals; Astrocytes; Brain Edema; Cell Size; Electrolytes; Glutamine; Hepatic Encephalopathy; Humans; Hyperammonemia; Hyponatremia; Water-Electrolyte Balance

2010
Severe hyperammonaemia in adults not explained by liver disease.
    Annals of clinical biochemistry, 2012, Volume: 49, Issue:Pt 3

    Topics: Adult; Amino Acids; Ammonia; Biological Transport; Blood-Brain Barrier; Brain; Glutamine; Humans; Hyperammonemia; Liver; Liver Diseases; Nitrogen; Urea; Urea Cycle Disorders, Inborn

2012
Pathogenesis of hepatic encephalopathy: lessons from nitrogen challenges in man.
    Metabolic brain disease, 2013, Volume: 28, Issue:2

    Topics: Amino Acids; Ammonia; Animals; Colon; Glutamine; Hepatic Encephalopathy; Humans; Hyperammonemia; Nitrogen

2013
[New concepts in the physiopathology of hepatic encephalopathy and therapeutic prospects].
    Gastroenterologia y hepatologia, 2004, Volume: 27 Suppl 1

    Topics: Ammonia; Brain; Brain Edema; Dipeptides; Flumazenil; Glutaminase; Glutamine; Hepatic Encephalopathy; Humans; Hyperammonemia; Inflammation; Intestine, Small; Kidney; Memantine; Models, Molecular; Nerve Tissue Proteins; Nitric Oxide

2004
An update on the role of brain glutamine synthesis and its relation to cell-specific energy metabolism in the hyperammonemic brain: further studies using NMR spectroscopy.
    Neurochemistry international, 2005, Volume: 47, Issue:1-2

    Topics: Animals; Astrocytes; Brain; Brain Edema; Energy Metabolism; Glutamine; Hepatic Encephalopathy; Humans; Hyperammonemia; Magnetic Resonance Spectroscopy; Water-Electrolyte Balance

2005
Valproate-induced hyperammonemic encephalopathy.
    Acta neurologica Scandinavica, 2006, Volume: 114, Issue:1

    Topics: Anticonvulsants; Brain; Brain Edema; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Carnitine; Diagnosis, Differential; Glutamic Acid; Glutamine; Hepatic Encephalopathy; Humans; Hyperammonemia; Valproic Acid

2006
Glutamine in the central nervous system: function and dysfunction.
    Frontiers in bioscience : a journal and virtual library, 2007, Jan-01, Volume: 12

    Topics: Animals; Brain; Brain Chemistry; Brain Diseases; Glutamine; Humans; Hyperammonemia; Mass Spectrometry; Nuclear Magnetic Resonance, Biomolecular; Spinal Cord

2007
Nuclear magnetic resonance studies of energy metabolism and glutamine shunt in hepatic encephalopathy and hyperammonemia.
    Journal of neuroscience research, 2007, Nov-15, Volume: 85, Issue:15

    Topics: Animals; Astrocytes; Brain; Energy Metabolism; Glutamine; Hepatic Encephalopathy; Humans; Hyperammonemia; Liver Failure; Magnetic Resonance Imaging

2007
The anaplerotic flux and ammonia detoxification in hepatic encephalopathy.
    Metabolic brain disease, 2007, Volume: 22, Issue:3-4

    Topics: Ammonia; Animals; Astrocytes; Brain; Citric Acid Cycle; Energy Metabolism; Glucose; Glutamine; Hepatic Encephalopathy; Humans; Hyperammonemia; Magnetic Resonance Spectroscopy; Pyruvate Carboxylase

2007
Energy metabolism in brain cells: effects of elevated ammonia concentrations.
    Metabolic brain disease, 2007, Volume: 22, Issue:3-4

    Topics: Ammonia; Animals; Astrocytes; Brain; Citric Acid Cycle; Energy Metabolism; Glucose; Glutamic Acid; Glutamine; Glycolysis; Humans; Hyperammonemia; Neurons; Pyruvic Acid

2007
Hyperammonemia in the ICU.
    Chest, 2007, Volume: 132, Issue:4

    Topics: Acute Disease; Algorithms; Ammonia; Astrocytes; Brain; Brain Edema; Cerebral Hemorrhage; Critical Care; Glutamine; Humans; Hyperammonemia; Hypothermia, Induced; Intensive Care Units; Liver; Liver Failure, Acute; Liver Function Tests; Metabolism, Inborn Errors; Muscle, Skeletal; Urea

2007
Mechanisms of brain edema in acute liver failure and impact of novel therapeutic interventions.
    Neurological research, 2007, Volume: 29, Issue:7

    Topics: Ammonia; Animals; Brain; Brain Diseases, Metabolic; Brain Edema; Energy Metabolism; Glutamine; Hepatic Encephalopathy; Humans; Hyperammonemia; Liver Failure, Acute

2007
In vivo nuclear magnetic resonance studies of glutamate-gamma-aminobutyric acid-glutamine cycling in rodent and human cortex: the central role of glutamine.
    The Journal of nutrition, 2001, Volume: 131, Issue:9 Suppl

    Topics: Acetates; Animals; Astrocytes; Biological Transport; Blood-Brain Barrier; Carbon Isotopes; Cerebral Cortex; Disease Models, Animal; gamma-Aminobutyric Acid; Glucose; Glutamic Acid; Glutamine; Humans; Hyperammonemia; Magnetic Resonance Spectroscopy; Neurons; Nitrogen Isotopes; Rats

2001
Role of glutamine in cerebral nitrogen metabolism and ammonia neurotoxicity.
    Mental retardation and developmental disabilities research reviews, 2001, Volume: 7, Issue:4

    Topics: Ammonia; Astrocytes; Brain; Cerebrovascular Circulation; Glutamic Acid; Glutamine; Humans; Hyperammonemia; Neurotoxins; Nitrogen; Osmotic Pressure

2001

Trials

4 trial(s) available for glutamine and Hyperammonemia

ArticleYear
Randomized, double-blind, controlled study of glycerol phenylbutyrate in hepatic encephalopathy.
    Hepatology (Baltimore, Md.), 2014, Volume: 59, Issue:3

    Topics: Adult; Aged; Ammonia; Double-Blind Method; Female; Glutamine; Glycerol; Hepatic Encephalopathy; Humans; Hyperammonemia; Male; Middle Aged; Phenylbutyrates; Treatment Outcome; Urea; Young Adult

2014
Glutamine and hyperammonemic crises in patients with urea cycle disorders.
    Molecular genetics and metabolism, 2016, Volume: 117, Issue:1

    Topics: Adolescent; Adult; Ammonia; Biomarkers; Child; Child, Preschool; Fasting; Female; Glutamine; Glycerol; Humans; Hyperammonemia; Male; Phenylbutyrates; Predictive Value of Tests; Urea Cycle Disorders, Inborn; Young Adult

2016
Induced hyperammonemia alters neuropsychology, brain MR spectroscopy and magnetization transfer in cirrhosis.
    Hepatology (Baltimore, Md.), 2003, Volume: 37, Issue:4

    Topics: Amino Acids; Ammonia; Body Water; Brain; Female; Glutamine; Hemoglobins; Humans; Hyperammonemia; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neuropsychological Tests; Protons; Solutions

2003
Low myo-inositol and high glutamine levels in brain are associated with neuropsychological deterioration after induced hyperammonemia.
    American journal of physiology. Gastrointestinal and liver physiology, 2004, Volume: 287, Issue:3

    Topics: Adult; Aged; Amino Acids; Ammonia; Basal Ganglia; Brain Chemistry; Choline; Creatinine; Female; Glutamine; Humans; Hyperammonemia; Inositol; Liver Cirrhosis; Liver Function Tests; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neuropsychological Tests; Signal Transduction; Temporal Lobe

2004

Other Studies

67 other study(ies) available for glutamine and Hyperammonemia

ArticleYear
Glutaminase 2 knockdown reduces hyperammonemia and associated lethality of urea cycle disorder mouse model.
    Journal of inherited metabolic disease, 2022, Volume: 45, Issue:3

    Topics: Ammonia; Animals; Disease Models, Animal; Glutaminase; Glutamine; Humans; Hyperammonemia; Liver; Mice; Ornithine Carbamoyltransferase; Ornithine Carbamoyltransferase Deficiency Disease; Urea; Urea Cycle Disorders, Inborn

2022
Interorgan amino acid interchange in propionic acidemia: the missing key to understanding its physiopathology.
    Amino acids, 2022, Volume: 54, Issue:5

    Topics: Alanine; Amino Acid Metabolism, Inborn Errors; Amino Acids; Ammonia; Glutamine; Humans; Hyperammonemia; Ketosis; Propionic Acidemia; Urea

2022
Low cerebral energy metabolism in hepatic encephalopathy reflects low neuronal energy demand. Role of ammonia-induced increased GABAergic tone.
    Analytical biochemistry, 2022, 10-01, Volume: 654

    Topics: Ammonia; Brain; Energy Metabolism; Glutamine; Hepatic Encephalopathy; Humans; Hyperammonemia; Neurons

2022
Moving towards a novel therapeutic strategy for hyperammonemia that targets glutamine metabolism.
    Journal of inherited metabolic disease, 2022, Volume: 45, Issue:6

    Topics: Ammonia; Animals; Fibroblasts; Glutamate Dehydrogenase; Glutamine; Hyperammonemia; Mice; Ornithine; Ornithine Carbamoyltransferase Deficiency Disease; Swine

2022
A mouse model of hepatic encephalopathy: bile duct ligation induces brain ammonia overload, glial cell activation and neuroinflammation.
    Scientific reports, 2022, 10-20, Volume: 12, Issue:1

    Topics: Ammonia; Animals; Bile Acids and Salts; Bile Ducts; Brain; Choline; Disease Models, Animal; Glutamine; Hepatic Encephalopathy; Hyperammonemia; Kynurenine; Liver Diseases; Mice; Microglia; Neuroinflammatory Diseases; Rats; Taurine; Tryptophan

2022
Treatment and outcomes of symptomatic hyperammonemia following asparaginase therapy in children with acute lymphoblastic leukemia.
    Molecular genetics and metabolism, 2023, Volume: 139, Issue:3

    Topics: Ammonia; Antineoplastic Agents; Asparaginase; Child; Glutamine; Humans; Hyperammonemia; Phenylbutyrates; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sodium Benzoate; Treatment Outcome

2023
Relationship between longitudinal changes in neuropsychological outcome and disease biomarkers in urea cycle disorders.
    Pediatric research, 2023, Volume: 94, Issue:6

    Topics: Ammonia; Biomarkers; Glutamine; Humans; Hyperammonemia; Longitudinal Studies; Neuropsychological Tests; Urea Cycle Disorders, Inborn

2023
The interaction of ammonia and manganese in abnormal metabolism of minimal hepatic encephalopathy: A comparison metabolomics study.
    PloS one, 2023, Volume: 18, Issue:8

    Topics: Alanine; Ammonia; Animals; Arginine; Brain; Citrulline; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Hepatic Encephalopathy; Hyperammonemia; Inositol; Isoleucine; Lactic Acid; Leucine; Manganese; Metabolomics; Rats; Rats, Sprague-Dawley; Taurine

2023
Lipid nanoparticle-targeted mRNA therapy as a treatment for the inherited metabolic liver disorder arginase deficiency.
    Proceedings of the National Academy of Sciences of the United States of America, 2019, 10-15, Volume: 116, Issue:42

    Topics: Ammonia; Animals; Arginase; Arginine; Codon; Disease Models, Animal; Glutamine; Hyperammonemia; Hyperargininemia; Lipids; Liver; Liver Diseases; Male; Mice; Mice, Inbred C57BL; Nanoparticles; RNA, Messenger; Urea

2019
Brain MRS glutamine as a biomarker to guide therapy of hyperammonemic coma.
    Molecular genetics and metabolism, 2017, Volume: 121, Issue:1

    Topics: Brain; Coma; Female; Gastric Bypass; Glutamates; Glutamine; Humans; Hyperammonemia; Magnetic Resonance Spectroscopy; Middle Aged; Phenylacetates; Sodium Benzoate; Treatment Outcome

2017
Identification of the molecular dysfunction caused by glutamate dehydrogenase S445L mutation responsible for hyperinsulinism/hyperammonemia.
    Human molecular genetics, 2017, 09-15, Volume: 26, Issue:18

    Topics: Adenosine Diphosphate; Amino Acids; Animals; Blood Glucose; Congenital Hyperinsulinism; Glucose; Glutamate Dehydrogenase; Glutamine; HEK293 Cells; Humans; Hyperammonemia; Hyperinsulinism; Insulin; Insulin Secretion; Insulin-Secreting Cells; Islets of Langerhans; Mice; Mice, Inbred C57BL; Mutation; Polymorphism, Single Nucleotide

2017
Safety, tolerability, and pharmacokinetics of l-ornithine phenylacetate in patients with acute liver injury/failure and hyperammonemia.
    Hepatology (Baltimore, Md.), 2018, Volume: 67, Issue:3

    Topics: Acetates; Adolescent; Adult; Aged; Ammonia; Female; Glutamine; Humans; Hyperammonemia; Kidney Function Tests; Liver; Liver Failure, Acute; Male; Middle Aged; Ornithine; Phenols; Registries; Treatment Outcome; Young Adult

2018
Prenatal treatment of ornithine transcarbamylase deficiency.
    Molecular genetics and metabolism, 2018, Volume: 123, Issue:3

    Topics: Ammonia; Drug Combinations; Female; Glutamine; Humans; Hyperammonemia; Infant, Newborn; Male; Mutation; Ornithine Carbamoyltransferase; Ornithine Carbamoyltransferase Deficiency Disease; Phenylacetates; Pregnancy; Prenatal Care; Prenatal Diagnosis; Sodium Benzoate; Treatment Outcome; Urea

2018
Conditional disruption of hepatic carbamoyl phosphate synthetase 1 in mice results in hyperammonemia without orotic aciduria and can be corrected by liver-directed gene therapy.
    Molecular genetics and metabolism, 2018, Volume: 124, Issue:4

    Topics: Ammonia; Animals; Carbamoyl-Phosphate Synthase (Ammonia); Carbamoyl-Phosphate Synthase I Deficiency Disease; Carbamyl Phosphate; Female; Gene Expression Regulation, Enzymologic; Genetic Therapy; Glutamine; Humans; Hyperammonemia; Liver; Male; Mice; Mice, Knockout; Mutation; Orotate Phosphoribosyltransferase; Orotidine-5'-Phosphate Decarboxylase; Purine-Pyrimidine Metabolism, Inborn Errors

2018
Effects of branched-chain amino acids on muscles under hyperammonemic conditions.
    Journal of physiology and biochemistry, 2018, Volume: 74, Issue:4

    Topics: Amino Acids, Branched-Chain; Ammonia; Animals; Carbon Radioisotopes; Citric Acid Cycle; Glutamine; Hyperammonemia; In Vitro Techniques; Ketoglutaric Acids; Liver Cirrhosis; Methylhistidines; Muscle Fibers, Fast-Twitch; Muscle Fibers, Slow-Twitch; Muscle Proteins; Organ Specificity; Osmolar Concentration; Oxidation-Reduction; Protein Biosynthesis; Proteolysis; Rats, Wistar

2018
The utility of EEG monitoring in neonates with hyperammonemia due to inborn errors of metabolism.
    Molecular genetics and metabolism, 2018, Volume: 125, Issue:3

    Topics: Amino Acid Metabolism, Inborn Errors; Ammonia; Argininosuccinate Synthase; Argininosuccinic Aciduria; Electroencephalography; Female; Glutamine; Humans; Hyperammonemia; Hypoxia-Ischemia, Brain; Infant; Infant, Newborn; Male; Metabolism, Inborn Errors; Ornithine Carbamoyltransferase Deficiency Disease; Seizures

2018
A constitutive knockout of murine carbamoyl phosphate synthetase 1 results in death with marked hyperglutaminemia and hyperammonemia.
    Journal of inherited metabolic disease, 2019, Volume: 42, Issue:6

    Topics: Animals; Animals, Newborn; Carbamoyl-Phosphate Synthase (Ammonia); Carbamoyl-Phosphate Synthase I Deficiency Disease; Glutamine; Hyperammonemia; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutation

2019
Taurine transporter (TauT) deficiency impairs ammonia detoxification in mouse liver.
    Proceedings of the National Academy of Sciences of the United States of America, 2019, 03-26, Volume: 116, Issue:13

    Topics: Ammonia; Animals; Deficiency Diseases; Disease Models, Animal; GABA Plasma Membrane Transport Proteins; Gene Knockdown Techniques; Glutamate-Ammonia Ligase; Glutamine; Glycoproteins; Hepatocytes; Hyperammonemia; Inactivation, Metabolic; Kinetics; Liver; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Mice, Knockout; Oxidative Stress; Perfusion; Urea

2019
Concentration-dependent bimodal effect of specific 18 kDa translocator protein (TSPO) ligands on cell death processes induced by ammonium chloride: potential implications for neuropathological effects due to hyperammonemia.
    CNS & neurological disorders drug targets, 2014, Volume: 13, Issue:4

    Topics: Ammonium Chloride; Benzodiazepinones; Cardiolipins; Cell Death; Cell Line, Tumor; Cell Shape; Dose-Response Relationship, Drug; GABA Agents; Glutamine; Humans; Hyperammonemia; Indoleacetic Acids; Isoquinolines; L-Lactate Dehydrogenase; Ligands; Lipid Peroxidation; Membrane Potential, Mitochondrial; Mitochondria; Neuroprotective Agents; Propidium; Receptors, GABA

2014
Blood ammonia and glutamine as predictors of hyperammonemic crises in patients with urea cycle disorder.
    Genetics in medicine : official journal of the American College of Medical Genetics, 2015, Volume: 17, Issue:7

    Topics: Adolescent; Adult; Ammonia; Child; Child, Preschool; Female; Glutamine; Humans; Hyperammonemia; Infant; Male; Middle Aged; Predictive Value of Tests; Urea Cycle Disorders, Inborn; Young Adult

2015
Fatal hyperammonemia and carbamoyl phosphate synthetase 1 (CPS1) deficiency following high-dose chemotherapy and autologous hematopoietic stem cell transplantation.
    Molecular genetics and metabolism, 2015, Volume: 114, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Edema; Carbamoyl-Phosphate Synthase (Ammonia); Carbamyl Phosphate; Carboplatin; Child, Preschool; Combined Modality Therapy; Etoposide; Fatal Outcome; Glutamine; Hematopoietic Stem Cell Transplantation; Hep G2 Cells; Humans; Hyperammonemia; Liver; Male; Middle Aged; Neuroblastoma; Ornithine Carbamoyltransferase; Oxidative Phosphorylation

2015
Secondary NAD+ deficiency in the inherited defect of glutamine synthetase.
    Journal of inherited metabolic disease, 2015, Volume: 38, Issue:6

    Topics: Amino Acid Metabolism, Inborn Errors; B-Lymphocytes; Cell Culture Techniques; Dietary Supplements; Fibroblasts; Glutamate-Ammonia Ligase; Glutamine; Humans; Hyperammonemia; NAD; Point Mutation

2015
Further Concerns About Glutamine: A Case Report on Hyperammonemic Encephalopathy.
    Critical care medicine, 2015, Volume: 43, Issue:10

    Topics: Brain Diseases, Metabolic; Dietary Supplements; Female; Glutamine; Humans; Hyperammonemia; Middle Aged

2015
Chrysin, a flavonoid attenuates histological changes of hyperammonemic rats: A dose dependent study.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2016, Volume: 82

    Topics: Ammonia; Animals; Bilirubin; Biomarkers; Body Weight; Brain; Creatinine; Dose-Response Relationship, Drug; Flavonoids; Glutamic Acid; Glutamine; Hyperammonemia; Kidney; Liver; Male; Models, Biological; Nitric Oxide; Rats, Wistar; Sodium-Potassium-Exchanging ATPase; Urea; Uric Acid

2016
Tolerance of hyperammonemia in brain of Heteropneustes fossilis is supported by glutamate-glutamine cycle.
    Journal of chemical neuroanatomy, 2017, Volume: 80

    Topics: Animals; Arginase; Brain; Brain Chemistry; Catfishes; Encephalitis; Gene Expression; Glutamic Acid; Glutamine; Hyperammonemia; Myelin Sheath; Neurodegenerative Diseases; Neuroglia; Neurons; RNA

2017
Amino acids in CSF and plasma in hyperammonaemic coma due to arginase1 deficiency.
    Journal of inherited metabolic disease, 2008, Volume: 31 Suppl 2

    Topics: Adult; Amino Acids; Ammonia; Arginine; Biomarkers; Chromatography, Ion Exchange; Coma; Glutamine; Humans; Hyperammonemia; Hyperargininemia; Lysine; Male; Ornithine

2008
A radiologic "alcohol breathalyzer" test.
    Neurology, 2009, Jan-13, Volume: 72, Issue:2

    Topics: Alcohol-Induced Disorders, Nervous System; Brain Diseases, Metabolic; Central Nervous System Depressants; Ethanol; Glutamine; Hepatic Encephalopathy; Humans; Hyperammonemia; Magnetic Resonance Spectroscopy; Male; Middle Aged; Predictive Value of Tests

2009
Valproate-induced metabolic changes in patients with epilepsy: assessment with H-MRS.
    Epilepsia, 2009, Volume: 50, Issue:3

    Topics: Adolescent; Adult; Anticonvulsants; Aspartic Acid; Choline; Creatine; Energy Metabolism; Epilepsies, Myoclonic; Epilepsies, Partial; Epilepsy, Tonic-Clonic; Female; Glutamic Acid; Glutamine; Humans; Hyperammonemia; Image Processing, Computer-Assisted; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Occipital Lobe; Parietal Lobe; Reference Values; Valproic Acid; Young Adult

2009
Simultaneous LC-MS/MS determination of phenylbutyrate, phenylacetate benzoate and their corresponding metabolites phenylacetylglutamine and hippurate in blood and urine.
    Journal of inherited metabolic disease, 2010, Volume: 33 Suppl 3

    Topics: Benzoates; Biomarkers; Biotransformation; Calibration; Chromatography, Reverse-Phase; Glutamine; Hippurates; Humans; Hyperammonemia; Limit of Detection; Linear Models; Phenylacetates; Phenylbutyrates; Predictive Value of Tests; Reference Standards; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Urea Cycle Disorders, Inborn

2010
Cyclophosphamide-induced leakage of gastrointestinal ammonia into the common bloodstream in rats.
    Drug and chemical toxicology, 2011, Volume: 34, Issue:1

    Topics: Ammonia; Animals; Antineoplastic Agents, Alkylating; Behavior, Animal; Cyclophosphamide; Dose-Response Relationship, Drug; Gastrointestinal Tract; Glutamine; Hyperammonemia; Injections, Intraperitoneal; Male; Rats; Toxicity Tests; Urea

2011
Magnetic resonance quantification of water and metabolites in the brain of cirrhotics following induced hyperammonaemia.
    Journal of hepatology, 2011, Volume: 54, Issue:6

    Topics: Amino Acids; Astrocytes; Body Water; Brain; Brain Edema; Glutamine; Hepatic Encephalopathy; Humans; Hyperammonemia; Liver Cirrhosis; Magnetic Resonance Spectroscopy; Middle Aged; Multivariate Analysis

2011
New insights on the mechanisms of valproate-induced hyperammonemia: inhibition of hepatic N-acetylglutamate synthase activity by valproyl-CoA.
    Journal of hepatology, 2011, Volume: 55, Issue:2

    Topics: Acyl Coenzyme A; Amino-Acid N-Acetyltransferase; Ammonia; Animals; Anticonvulsants; Citrulline; Disease Models, Animal; Glutamates; Glutamine; Humans; Hyperammonemia; In Vitro Techniques; Liver; Male; Mice; Mice, Inbred C57BL; Models, Biological; Rats; Rats, Wistar; Urea; Valproic Acid

2011
Ammonia redistribution from the gastrointestinal tract to general circulation after intraperitoneal injection of cyclophosphamide to rats.
    Bulletin of experimental biology and medicine, 2010, Volume: 150, Issue:2

    Topics: Alanine Transaminase; Ammonia; Animals; Aspartate Aminotransferases; Cyclophosphamide; Dose-Response Relationship, Drug; Gastrointestinal Tract; Glutamine; Hyperammonemia; Injections, Intraperitoneal; L-Lactate Dehydrogenase; Male; Rats; Urea

2010
Pro-inflammatory cytokines are raised in extrahepatic portal venous obstruction, with minimal hepatic encephalopathy.
    Journal of gastroenterology and hepatology, 2011, Volume: 26, Issue:6

    Topics: Adolescent; Adult; Ammonia; Brain; Brain Edema; Case-Control Studies; Child; Diffusion Tensor Imaging; Female; Glutamine; Hepatic Encephalopathy; Humans; Hyperammonemia; India; Inflammation Mediators; Interleukin-6; Magnetic Resonance Spectroscopy; Male; Neuropsychological Tests; Portal Vein; Tumor Necrosis Factor-alpha; Up-Regulation; Vascular Diseases; Young Adult

2011
Hypermagnesemia does not prevent intracranial hypertension and aggravates cerebral hyperperfusion in a rat model of acute hyperammonemia.
    Hepatology (Baltimore, Md.), 2011, Volume: 53, Issue:6

    Topics: Ammonia; Animals; Aquaporin 4; Blood Pressure; Brain; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Glutamic Acid; Glutamine; Hyperammonemia; Intracranial Hypertension; Intracranial Pressure; Magnesium Sulfate; Male; Models, Animal; Rats; Rats, Wistar; Regional Blood Flow

2011
Inhibition of glutamine synthesis induces glutamate dehydrogenase-dependent ammonia fixation into alanine in co-cultures of astrocytes and neurons.
    Neurochemistry international, 2011, Volume: 59, Issue:4

    Topics: Alanine; Alanine Transaminase; Ammonia; Animals; Astrocytes; Cells, Cultured; Cerebral Cortex; Coculture Techniques; Glutamate Dehydrogenase; Glutamate-Ammonia Ligase; Glutamine; Hyperammonemia; Methionine Sulfoximine; Mice; Mice, Inbred Strains; Neurons

2011
Encephalopathy in acute liver failure resulting from acetaminophen intoxication: new observations with potential therapy.
    Critical care medicine, 2011, Volume: 39, Issue:11

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Brain Diseases; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Glutamine; Humans; Hyperammonemia; Liver Failure, Acute

2011
The nuclear receptor FXR regulates hepatic transport and metabolism of glutamine and glutamate.
    Biochimica et biophysica acta, 2011, Volume: 1812, Issue:11

    Topics: Amino-Acid N-Acetyltransferase; Animals; Blotting, Western; Carbon Tetrachloride; Cell Nucleus; Chromatin Immunoprecipitation; Electrophoretic Mobility Shift Assay; Glutamates; Glutamine; Hep G2 Cells; Hepatocytes; Humans; Hyperammonemia; Liver Cirrhosis, Experimental; Luciferases; Mice; Mice, Inbred C57BL; Mice, Knockout; Promoter Regions, Genetic; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger

2011
Ornithine transcarbamylase deficiency presenting as recurrent abdominal pain in childhood.
    Pediatric emergency care, 2011, Volume: 27, Issue:9

    Topics: Abdominal Pain; Alkalosis, Respiratory; Arginine; Carbamoyl-Phosphate Synthase I Deficiency Disease; Child, Preschool; Citrulline; Consciousness Disorders; Diagnosis, Differential; Diet, Protein-Restricted; Emergencies; Exons; Female; Glutamine; Humans; Hyperammonemia; Language Development Disorders; Liver Transplantation; Mutation, Missense; Ornithine Carbamoyltransferase; Ornithine Carbamoyltransferase Deficiency Disease; Phenylbutyrates; Recurrence

2011
Cerebral glutamine metabolism under hyperammonemia determined in vivo by localized (1)H and (15)N NMR spectroscopy.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2012, Volume: 32, Issue:4

    Topics: Ammonia; Animals; Brain; Glutamate-Ammonia Ligase; Glutamic Acid; Glutamine; Hyperammonemia; Magnetic Resonance Spectroscopy; Male; Models, Biological; Nitrogen Isotopes; Rats; Rats, Sprague-Dawley

2012
Efficacy of oral L-ornithine L-aspartate in cirrhotic patients with hyperammonemic hepatic encephalopathy.
    Annals of hepatology, 2011, Volume: 10 Suppl 2

    Topics: Administration, Oral; Ammonia; Dipeptides; Glutamine; Hepatic Encephalopathy; Humans; Hyperammonemia; Liver Cirrhosis; Quality of Life; Severity of Illness Index; Treatment Outcome; Urea

2011
The effect of fractionated plasma separation and adsorption on cerebral amino acid metabolism and oxidative metabolism during acute liver failure.
    Journal of hepatology, 2012, Volume: 57, Issue:4

    Topics: Adult; Amino Acids; Cerebrum; Dialysis Solutions; Extracorporeal Circulation; Female; Glutamine; Hepatic Encephalopathy; Humans; Hyperammonemia; Intracranial Hypertension; Intracranial Pressure; Lactic Acid; Liver Failure, Acute; Male; Microdialysis; Middle Aged; Pyruvic Acid; Sorption Detoxification; Statistics, Nonparametric

2012
Interorgan metabolism of ornithine phenylacetate (OP)--a novel strategy for treatment of hyperammonemia.
    Biochemical pharmacology, 2013, Jan-01, Volume: 85, Issue:1

    Topics: Acetates; Ammonia; Animals; Arteries; Bile Ducts; Drug Interactions; Female; Glutamine; Hyperammonemia; Kidney; Ligation; Liver; Liver Cirrhosis, Biliary; Muscle, Skeletal; Nitrogen Isotopes; Ornithine; Phenols; Rats; Rats, Wistar; Tissue Distribution

2013
Aggravation of cyclophosphamide-induced acute neurological disorders under conditions of artificial acidification of chyme in rats.
    Bulletin of experimental biology and medicine, 2012, Volume: 153, Issue:6

    Topics: Acute Disease; Administration, Oral; Ammonia; Animals; Boric Acids; Cyclophosphamide; Gastric Juice; Gastric Mucosa; Glutamine; Hydrochloric Acid; Hydrogen-Ion Concentration; Hyperammonemia; Lactic Acid; Male; Neurotoxicity Syndromes; Rats; Stomach; Sulfuric Acids; Survival Rate; Urea

2012
Comparison of the effects of ammonia on brain mitochondrial function in rats and gulf toadfish.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2002, Volume: 283, Issue:3

    Topics: Ammonia; Animals; Antimycin A; Batrachoidiformes; Brain; Cyanides; Electron Transport; Glutamine; Hepatic Encephalopathy; Hyperammonemia; Mitochondria; NAD; Organ Culture Techniques; Rats; Rats, Wistar; Rotenone; Species Specificity; Uncoupling Agents

2002
Valproate-induced encephalopathy: assessment with MR imaging and 1H MR spectroscopy.
    Epilepsia, 2002, Volume: 43, Issue:9

    Topics: Adult; Anticonvulsants; Aspartic Acid; Brain; Brain Diseases, Metabolic; Choline; Creatine; Epilepsy; Glutamic Acid; Glutamine; Humans; Hyperammonemia; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Occipital Lobe; Valproic Acid

2002
[Hyperammoniemia induced by glutamine in cirrhotics. The renal origin of this hyperammoniemia].
    Revue francaise d'etudes cliniques et biologiques, 1962, Volume: 7

    Topics: Ammonia; Glutamine; Humans; Hyperammonemia; Kidney; Liver Cirrhosis

1962
Hepatic encephalopathy.
    The New England journal of medicine, 1986, Mar-20, Volume: 314, Issue:12

    Topics: Animals; Astrocytes; Brain; Glutamine; Hepatic Encephalopathy; Humans; Hyperammonemia

1986
Ammonia effects on pyruvate/lactate production in astrocytes--interaction with glutamate.
    Neurochemistry international, 2005, Volume: 47, Issue:1-2

    Topics: Ammonia; Animals; Animals, Newborn; Aspartic Acid; Astrocytes; Bucladesine; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Energy Metabolism; Glutamic Acid; Glutamine; Glutathione; Glycolysis; Hyperammonemia; Interneurons; Lactic Acid; Malates; Mice; Mitochondria; Oxidation-Reduction; Oxidative Stress; Pyruvic Acid; Up-Regulation

2005
Ammonia toxicity under hyponatremic conditions in astrocytes: de novo synthesis of amino acids for the osmoregulatory response.
    Neurochemistry international, 2005, Volume: 47, Issue:1-2

    Topics: Alanine; Amino Acids; Ammonia; Ammonium Chloride; Animals; Animals, Newborn; Astrocytes; Brain Edema; Cell Size; Cells, Cultured; Citric Acid Cycle; Glucose; Glutamine; Glutathione; Hepatic Encephalopathy; Hyperammonemia; Hyponatremia; Inositol; Intracellular Fluid; Magnetic Resonance Spectroscopy; Osmolar Concentration; Rats; Rats, Wistar; Taurine; Water-Electrolyte Balance

2005
Suppression of glial glutamine release to the extracellular fluid studied in vivo by NMR and microdialysis in hyperammonemic rat brain.
    Journal of neurochemistry, 2005, Volume: 94, Issue:1

    Topics: Animals; Brain; Extracellular Fluid; Glutamine; Hyperammonemia; Infusions, Intravenous; Magnetic Resonance Spectroscopy; Male; Microdialysis; Neuroglia; Rats; Rats, Wistar

2005
Persistent arterial hyperammonemia increases the concentration of glutamine and alanine in the brain and correlates with intracranial pressure in patients with fulminant hepatic failure.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2006, Volume: 26, Issue:1

    Topics: Adolescent; Adult; Aged; Alanine; Brain; Female; Glutamine; Humans; Hyperammonemia; Intracranial Hypertension; Intracranial Pressure; Liver Failure, Acute; Liver Function Tests; Male; Microdialysis; Middle Aged; Prospective Studies

2006
Ornithine aminotransferase deficiency: diagnostic difficulties in neonatal presentation.
    Journal of inherited metabolic disease, 2005, Volume: 28, Issue:5

    Topics: Amino Acid Metabolism, Inborn Errors; Ammonia; Arginine; Citrulline; Diagnosis, Differential; Female; Fibroblasts; Glutamine; Humans; Hyperammonemia; Infant, Newborn; Male; Mutation; Neonatal Screening; Ornithine; Ornithine-Oxo-Acid Transaminase; Orotic Acid

2005
Metabolic changes associated with hyperammonemia in patients with propionic acidemia.
    Molecular genetics and metabolism, 2006, Volume: 88, Issue:2

    Topics: Amino Acid Metabolism, Inborn Errors; Child; Child, Preschool; Glutamic Acid; Glutamine; Humans; Hyperammonemia; Infant; Infant, Newborn; Propionates

2006
Ornithine restores ureagenesis capacity and mitigates hyperammonemia in Otc(spf-ash) mice.
    The Journal of nutrition, 2006, Volume: 136, Issue:7

    Topics: Amino Acids; Animals; Glutamine; Hyperammonemia; Mice; Ornithine; Ornithine Carbamoyltransferase; Ornithine Carbamoyltransferase Deficiency Disease; Urea

2006
Interorgan ammonia, glutamate, and glutamine trafficking in pigs with acute liver failure.
    American journal of physiology. Gastrointestinal and liver physiology, 2006, Volume: 291, Issue:3

    Topics: Ammonia; Animals; Biological Transport, Active; Female; Glutamic Acid; Glutamine; Hyperammonemia; Kidney; Liver; Liver Failure, Acute; Lung; Organ Specificity; Swine; Tissue Distribution

2006
Kinetics of glial glutamine efflux and the mechanism of neuronal uptake studied in vivo in mildly hyperammonemic rat brain.
    Journal of neurochemistry, 2006, Volume: 99, Issue:4

    Topics: Amino Acid Transport System A; Amino Acid Transport System ASC; Amino Acid Transport System y+; Amino Acid Transport Systems; Animals; Brain; Cell Communication; Enzyme Inhibitors; Extracellular Fluid; Fusion Regulatory Protein 1, Light Chains; Glutamic Acid; Glutamine; Hyperammonemia; Kinetics; Magnetic Resonance Spectroscopy; Male; Microdialysis; Minor Histocompatibility Antigens; Neuroglia; Neurons; Rats; Rats, Wistar

2006
Hyperammonemia acts synergistically with lipopolysaccharide in inducing changes in cerebral hemodynamics in rats anaesthetised with pentobarbital.
    Journal of hepatology, 2007, Volume: 47, Issue:2

    Topics: Amiloride; Ammonia; Anesthesia; Animals; Blood Pressure; Brain; Cerebral Cortex; Cerebrovascular Circulation; Drug Synergism; Glutamic Acid; Glutamine; Hyperammonemia; Intracranial Pressure; Lipopolysaccharides; Male; Osmolar Concentration; Pentobarbital; Rats; Rats, Wistar; Sodium Channel Blockers; Sodium-Hydrogen Exchangers; Tumor Necrosis Factor-alpha

2007
Magnetic resonance spectroscopy in adult-onset citrullinemia: elevated glutamine levels in comatose patients.
    Archives of neurology, 2007, Volume: 64, Issue:7

    Topics: Adult; Ammonia; Biomarkers; Brain; Brain Mapping; Cerebral Cortex; Choline; Citrulline; Citrullinemia; Coma; Diffusion Magnetic Resonance Imaging; Disease Progression; Early Diagnosis; Fatal Outcome; Glutamic Acid; Glutamine; Gyrus Cinguli; Humans; Hyperammonemia; Inositol; Magnetic Resonance Spectroscopy; Male; Predictive Value of Tests

2007
Effect of ammonia, glutamine, and serum on calcineurin, p38MAPK-diP, GADD153/CHOP10, and CNTF in primary rat astrocyte cultures.
    Brain research, 2007, Oct-17, Volume: 1175

    Topics: Ammonia; Animals; Astrocytes; Blood Proteins; Brain; Calcineurin; Cells, Cultured; Ciliary Neurotrophic Factor; Culture Media; Glutamine; Hepatic Encephalopathy; Hyperammonemia; p38 Mitogen-Activated Protein Kinases; Rats; Rats, Wistar; Signal Transduction; Transcription Factor CHOP

2007
Cerebral glutamine concentration and lactate-pyruvate ratio in patients with acute liver failure.
    Neurocritical care, 2008, Volume: 9, Issue:1

    Topics: Adolescent; Adult; Aged; Astrocytes; Brain; Brain Edema; Critical Care; Female; Glutamine; Humans; Hyperammonemia; Intracranial Hypertension; Lactic Acid; Liver Failure, Acute; Male; Microdialysis; Middle Aged; Mitochondria; Pyruvic Acid; Severity of Illness Index

2008
Postchemotherapy hyperammonemic encephalopathy emulating ornithine transcarbamoylase (OTC) deficiency.
    Southern medical journal, 2008, Volume: 101, Issue:5

    Topics: Adult; Arginine; Carcinoma, Hepatocellular; Citrulline; Female; Glutamine; Hepatic Encephalopathy; Humans; Hyperammonemia; Liver Neoplasms; Ornithine; Ornithine Carbamoyltransferase Deficiency Disease; Orotic Acid; Polymorphism, Single-Stranded Conformational; Syndrome

2008
Induction of permeability transition and swelling of rat brain mitochondria by glutamine.
    Neurotoxicology, 2000, Volume: 21, Issue:3

    Topics: Animals; Brain; Female; Glutamine; Hyperammonemia; Mitochondria; Mitochondrial Swelling; Rats; Rats, Wistar

2000
In vivo (13)C NMR measurement of neurotransmitter glutamate cycling, anaplerosis and TCA cycle flux in rat brain during.
    Journal of neurochemistry, 2001, Volume: 76, Issue:4

    Topics: Acetates; Ammonia; Animals; Astrocytes; Blood Glucose; Brain; Brain Chemistry; Carbon Isotopes; Cerebral Cortex; Citric Acid Cycle; Glucose; Glutamic Acid; Glutamine; Homeostasis; Hyperammonemia; Magnetic Resonance Spectroscopy; Male; Models, Theoretical; Neurons; Rats; Rats, Sprague-Dawley

2001
Ammonia-induced production of free radicals in primary cultures of rat astrocytes.
    Journal of neuroscience research, 2001, Oct-15, Volume: 66, Issue:2

    Topics: Ammonium Chloride; Animals; Astrocytes; Catalase; Cells, Cultured; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Fluorometry; Free Radicals; Glutamate-Ammonia Ligase; Glutamine; Hyperammonemia; Lipid Peroxidation; Methionine Sulfoximine; Nerve Tissue Proteins; Rats; Superoxide Dismutase

2001
Extracorporeal dialysis in neonatal hyperammonemia: modalities and prognostic indicators.
    Pediatric nephrology (Berlin, Germany), 2001, Volume: 16, Issue:11

    Topics: Coma; Glutamine; Humans; Hyperammonemia; Infant, Newborn; Prognosis; Quaternary Ammonium Compounds; Renal Dialysis; Time Factors

2001
Serum and CSF glutamine levels in valproate-related hyperammonemic encephalopathy.
    Epilepsia, 2002, Volume: 43, Issue:2

    Topics: Adolescent; Adult; Ammonia; Anticonvulsants; Brain; Brain Diseases; Electroencephalography; Female; Glutamine; Humans; Hyperammonemia; Male; Middle Aged; Valproic Acid

2002