glutamine has been researched along with HbS Disease in 48 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (4.17) | 18.7374 |
| 1990's | 4 (8.33) | 18.2507 |
| 2000's | 3 (6.25) | 29.6817 |
| 2010's | 19 (39.58) | 24.3611 |
| 2020's | 20 (41.67) | 2.80 |
| Authors | Studies |
|---|---|
| Alkindi, S; Estepp, J; Ezzat, H; Lam, H; Minniti, CP; Shah, N; Zaidi, AU | 1 |
| Cimpeanu, E; Dutta, D; Jafri, F; Leibovitch, JN; Lim, SH; Poplawska, M; Tambe, AV | 1 |
| Hagar, R; Kuypers, FA; Larkin, S; Lavrisha, L; Morris, CR; Saulys, A; Suh, JH; Vichinsky, EP | 1 |
| Cimpeanu, E; Dutta, D; Jafri, F; Jang, T; Lim, SH; Poplawska, M; Seong, G | 1 |
| Fasipe, TA; Kavanagh, PL; Wun, T | 1 |
| Hagar, R; Hohman, LS; Kuypers, FA; Lavrisha, L; Lum, JJ; Morris, CR; Rokeby, A; Saulys, A; Vichinsky, E; Walter, PB | 1 |
| Gannon, M; Hsu, LL; Wu, HW | 1 |
| Lee, MT; Ogu, UO | 1 |
| Ataga, KI; Desai, PC; Rai, P | 1 |
| Adel, AM; Al-Okka, R; Elenga, N; Etienne-Julan, M; Loko, G; Yassin, MA | 1 |
| Cappellini, MD; Ferraresi, M; Kattamis, A; Leoni, S; Motta, I; Panzieri, DL | 1 |
| Jonassaint, CR; Kane-Gill, SL; Newman, TV; Novelli, EM; Suh, K; Yang, J | 1 |
| Carden, MA; Little, J | 1 |
| Howell, CM; Monus, T | 1 |
| Burns, BN; Cieri-Hutcherson, NE; Conway-Habes, EE; Hutcherson, TC; White, NA | 1 |
| Quinn, CT; Sadaf, A | 1 |
| Cox, SE; Hart, E; Kirkham, FJ; Stotesbury, H | 1 |
| Gordeuk, VR; Han, J; Saraf, SL | 1 |
| Adams, CD | 1 |
| Hehre, RJ | 1 |
| Ashley-Koch, AE; Bartolucci, P; Brugnara, C; Clish, CB; Galactéros, F; Garrett, ME; Hirschhorn, JN; Ilboudo, Y; Lettre, G; Telen, MJ | 1 |
| Chan, F; Crouch, A; Minniti, CP; Ogu, UO; Sebastian, G; Thomas, M; Vattappally, L; You, S | 1 |
| Rungkitwattanakul, D; Singh, D; Weaver, SB | 1 |
| Wilmore, DW | 1 |
| Aschenbrenner, DS | 1 |
| Ortiz de Montellano, PR | 1 |
| Ansari, J; Gavins, FNE; Moufarrej, YE; Pawlinski, R | 1 |
| Akhter, R; Ali, SI; Khan, A | 1 |
| Quinn, CT | 1 |
| Minniti, CP | 1 |
| Bellevue, R; Blake, OA; Gordeuk, VR; Guillaume, E; Hsu, LL; Kanter, J; Lanzkron, S; Lasky, JL; Miller, ST; Neumayr, LD; New, TN; Niihara, Y; Osunkwo, I; Panosyan, EH; Razon, RL; Sadanandan, S; Sarnaik, S; Sieger, L; Smith, WR; Stark, CW; Tran, LT; Vichinsky, EP; Viswanathan, K | 1 |
| Ataga, KI | 1 |
| Niihara, Y; Smith, WR; Stark, CW | 1 |
| Guddati, AK; Kota, V | 1 |
| Anker, MS; Anker, SD; Haverkamp, W | 1 |
| Hoppe, C; Neumayr, L | 1 |
| Simpson, S | 1 |
| Cremer, L; Li, CS; Mackert, P; Olivi, S; Storm, M; Wang, W; Williams, R | 1 |
| Ames, B; Bland, DA; Hagar, W; Klings, ES; Kuypers, FA; Larkin, S; Morris, CR; Shigenaga, M; Steinberg, MH; Suh, JH; Vichinsky, EP | 1 |
| Leboulch, P; London, IM; Oh, YH; Takekoshi, KJ; Westerman, KW | 1 |
| Bayne, E; Darmaun, D; Haymond, MW; Pitel, P; Sager, BK; Salman, EK; Wiisanen, A | 1 |
| Akiyama, DS; Niihara, Y; Tanaka, KR; Zerez, CR | 2 |
| Ellory, JC; Gibson, JS; Kiessling, K; Roberts, N | 1 |
| Rumen, NM | 1 |
| Cawein, MJ; Gleason, EM; Mackenzie, RD; Schatzman, GL | 1 |
16 review(s) available for glutamine and HbS Disease
| Article | Year |
|---|---|
l-glutamine, crizanlizumab, voxelotor, and cell-based therapy for adult sickle cell disease: Hype or hope?
Topics: Adult; Anemia, Sickle Cell; Antibodies, Monoclonal, Humanized; Benzaldehydes; Glutamine; Hematopoietic Stem Cell Transplantation; Humans; Pyrazines; Pyrazoles | 2022 |
L-glutamine for sickle cell disease: more than reducing redox.
Topics: Anemia, Sickle Cell; Glutamine; Hemoglobinopathies; Humans; NAD; Oxidation-Reduction; Volatile Organic Compounds | 2022 |
Sickle Cell Disease: A Review.
Topics: Adult; Anemia, Sickle Cell; Antibodies, Monoclonal, Humanized; Antisickling Agents; Benzaldehydes; Child; Glutamine; Hematologic Agents; Hematopoietic Stem Cell Transplantation; Humans; Hydroxyurea; Infant, Newborn; Neonatal Screening; Pain; Pyrazines; Pyrazoles; Transition to Adult Care; United States | 2022 |
Sickle cell disease in the new era: advances in drug treatment.
Topics: Anemia, Sickle Cell; Fetal Hemoglobin; Glutamine; Hemoglobin, Sickle; Hemoglobins; Humans; Hydroxyurea; Nitric Oxide; Oxidants; Oxygen; United States | 2022 |
The Evolving Landscape of Drug Therapies for Sickle Cell Disease.
Topics: Anemia, Sickle Cell; Genetic Therapy; Glutamine; Hematopoietic Stem Cell Transplantation; Humans; Hydroxyurea | 2022 |
Therapeutic perspective for children and young adults living with thalassemia and sickle cell disease.
Topics: Anemia, Sickle Cell; Child; Child, Preschool; Glutamine; Hemoglobinopathies; Humans; Infant; Thalassemia; Young Adult | 2023 |
Emerging disease-modifying therapies for sickle cell disease.
Topics: Anemia, Sickle Cell; Antioxidants; Antisickling Agents; Blood Coagulation; Clinical Trials as Topic; Drug Approval; Erythrocytes; Fetal Hemoglobin; Glutamine; Hematopoietic Stem Cell Transplantation; Hemoglobin, Sickle; Humans; Hydroxyurea; Inflammation; Platelet Activation; Polymers; United States; United States Food and Drug Administration | 2019 |
Current and emerging treatments for sickle cell disease.
Topics: Acute Chest Syndrome; Acute Disease; Analgesics, Opioid; Anemia, Sickle Cell; Anti-Bacterial Agents; Antisickling Agents; Chronic Disease; Disease Progression; Erythrocyte Transfusion; Fluid Therapy; Genetic Therapy; Glutamine; Hematopoietic Stem Cell Transplantation; Humans; Hydroxyurea; Infant, Newborn; Infection Control; Infections; Mesenteric Ischemia; Neonatal Screening; Oxygen Inhalation Therapy; Pain Management; Patient Education as Topic; Pneumococcal Infections; Pneumococcal Vaccines; Stroke | 2019 |
Systematic Review of l-glutamine for Prevention of Vaso-occlusive Pain Crisis in Patients with Sickle Cell Disease.
Topics: Anemia, Sickle Cell; Glutamine; Hospitalization; Humans; Pain; Randomized Controlled Trials as Topic | 2019 |
L-glutamine for sickle cell disease: Knight or pawn?
Topics: Anemia, Sickle Cell; Animals; Clinical Trials as Topic; Glutamine; Glutathione; Humans; Intestines; Nitric Oxide | 2020 |
Systematic Review of Crizanlizumab: A New Parenteral Option to Reduce Vaso-occlusive Pain Crises in Patients with Sickle Cell Disease.
Topics: Anemia, Sickle Cell; Animals; Antibodies, Monoclonal, Humanized; Glutamine; Humans; Hydroxyurea; P-Selectin; Pain; Randomized Controlled Trials as Topic | 2020 |
Managing patients with sickle cell disease in primary care.
Topics: Administration, Oral; Anemia, Sickle Cell; Antibodies, Monoclonal, Humanized; Antisickling Agents; Blood Transfusion; Evidence-Based Medicine; Female; Glutamine; Hematopoietic Stem Cell Transplantation; Humans; Hydroxyurea; Iodine Isotopes; Maintenance Chemotherapy; Male; Monitoring, Physiologic; Practice Guidelines as Topic; Primary Health Care | 2020 |
Contemporary Management and Prevention of Vaso-Occlusive Crises (VOCs) in Adults With Sickle Cell Disease.
Topics: Adult; Anemia, Sickle Cell; Glutamine; Hospitalization; Humans; Hydroxyurea | 2023 |
Sickle cell disease: a malady beyond a hemoglobin defect in cerebrovascular disease.
Topics: Anemia, Sickle Cell; Antisickling Agents; Cell Communication; Cerebrovascular Disorders; Disease Progression; Glutamine; Hemoglobins; Humans; Hydroxyurea; Inflammation; Mutation; Neutrophils; Quality of Life | 2018 |
l-Glutamine for sickle cell anemia: more questions than answers.
Topics: Adolescent; Adult; Anemia, Sickle Cell; Child; Child, Preschool; Drug Approval; Female; Glutamine; Humans; Hydroxyurea; Male; United States; United States Food and Drug Administration | 2018 |
Sickle Cell Disease: Monitoring, Current Treatment, and Therapeutics Under Development.
Topics: Anemia, Sickle Cell; Antisickling Agents; Child; Clinical Trials as Topic; Erythrocyte Transfusion; Glutamine; Humans; Hydroxyurea; Monitoring, Physiologic; Stem Cell Transplantation | 2019 |
4 trial(s) available for glutamine and HbS Disease
| Article | Year |
|---|---|
The effects of glutamine supplementation on markers of apoptosis and autophagy in sickle cell disease peripheral blood mononuclear cells.
Topics: Adult; Anemia, Sickle Cell; Apoptosis; Autophagy; bcl-2-Associated X Protein; Biomarkers; Dietary Supplements; Female; Glutamine; Humans; Leukocytes, Mononuclear; Male; Middle Aged; Prospective Studies; Tricuspid Valve Insufficiency | 2022 |
A Phase 3 Trial of l-Glutamine in Sickle Cell Disease.
Topics: Administration, Oral; Adolescent; Adult; Anemia, Sickle Cell; Antisickling Agents; beta-Thalassemia; Child; Child, Preschool; Double-Blind Method; Drug Therapy, Combination; Female; Glutamine; Humans; Hydroxyurea; Intention to Treat Analysis; Male; Middle Aged; Pain; Pain Management; Young Adult | 2018 |
Oral glutamine supplementation decreases resting energy expenditure in children and adolescents with sickle cell anemia.
Topics: Administration, Oral; Adolescent; Amino Acids; Anemia, Sickle Cell; Basal Metabolism; Body Composition; Child; Child, Preschool; Female; Glutamine; Growth; Humans; Male; Nutritional Status; Patient Compliance; Treatment Outcome; Tryptophan; Weight Gain | 2004 |
Oral L-glutamine therapy for sickle cell anemia: I. Subjective clinical improvement and favorable change in red cell NAD redox potential.
Topics: Administration, Oral; Adult; Anemia, Sickle Cell; Dietary Supplements; Erythrocytes; Glutamine; Humans; Middle Aged; NAD; Oxidation-Reduction; Pilot Projects; Treatment Outcome | 1998 |
28 other study(ies) available for glutamine and HbS Disease
| Article | Year |
|---|---|
A reanalysis of pain crises data from the pivotal l-glutamine in sickle cell disease trial.
Topics: Anemia, Sickle Cell; Communication; Glutamine; Humans; Pain | 2021 |
Implications for the metabolic fate of oral glutamine supplementation within plasma and erythrocytes of patients with sickle cell disease: A pharmacokinetics study.
Topics: Amino Acids; Anemia, Sickle Cell; Dietary Supplements; Erythrocytes; Female; Glutamine; Humans; Middle Aged | 2022 |
Evaluation of Glutamine Utilization in Patients With Sickle Cell Disease.
Topics: Adult; Anemia, Sickle Cell; Child; Glutamine; Humans; Medication Adherence; Retrospective Studies | 2023 |
"Long-term efficacy and safety of L-glutamine in preventing sickle cell disease-related acute complications and hemolysis in pediatric and adult patients-Real-world, observational study".
Topics: Adult; Anemia, Sickle Cell; Child; Glutamine; Hemolysis; Humans; Pain | 2023 |
Use of Disease-Modifying Treatments in Patients With Sickle Cell Disease.
Topics: Acute Chest Syndrome; Adult; Anemia, Sickle Cell; Child; Cross-Sectional Studies; Female; Glutamine; Humans; Hydroxyurea; Inpatients; Male | 2023 |
L-Glutamine in sickle cell disease.
Topics: Adult; Anemia, Sickle Cell; Animals; Child; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Double-Blind Method; Erythrocytes; Glutamine; Humans; Mice; NAD; Randomized Controlled Trials as Topic | 2020 |
A Mendelian randomization study of circulating glutamine and red blood cell traits.
Topics: Acute Pain; Anemia, Sickle Cell; Erythrocytes; Glutamine; Humans; Mendelian Randomization Analysis; Oxidative Stress | 2020 |
Potential causal role of l-glutamine in sickle cell disease painful crises: A Mendelian randomization analysis.
Topics: Adolescent; Adult; Anemia, Sickle Cell; Child; Child, Preschool; Female; Glutamine; Humans; Male; Mendelian Randomization Analysis; Middle Aged; Pain; Young Adult | 2021 |
L-glutamine use in adults with sickle cell disease: Clinical trials where success meets reality.
Topics: Adult; Aged; Anemia, Sickle Cell; Clinical Trials as Topic; Female; Follow-Up Studies; Glutamine; Humans; Male; Middle Aged; Retrospective Studies | 2021 |
Food and Drug Administration Approval of Glutamine for Sickle Cell Disease: Success and Precautions in Glutamine Research.
Topics: Anemia, Sickle Cell; Drug Approval; Enteral Nutrition; Glutamine; Humans; Outcome Assessment, Health Care; Parenteral Nutrition; Research; United States; United States Food and Drug Administration | 2017 |
New Drug for Sickle Cell Disease.
Topics: Administration, Oral; Anemia, Sickle Cell; Drug Approval; Glutamine; Humans | 2017 |
A New Step in the Treatment of Sickle Cell Disease
Topics: Amide Synthases; Ammonia; Anemia, Sickle Cell; Animals; Antisickling Agents; Drug Discovery; Glutaminase; Glutamine; Humans; NAD | 2018 |
L-glutamine (Endari) for sickle cell disease.
Topics: Anemia, Sickle Cell; Antisickling Agents; Drug Costs; Drug Interactions; Glutamine; Humans; Treatment Outcome | 2018 |
Challenges and new horizons for sickle cell disease.
Topics: Adult; Anemia, Sickle Cell; Clinical Trials as Topic; Glutamine; Humans | 2018 |
L-Glutamine approved for use in patients with sickle cell disease.
Topics: Acute Chest Syndrome; Anemia, Sickle Cell; Drug Approval; Glutamine; Hospitalization; Humans | 2018 |
l-Glutamine and the Dawn of Combination Therapy for Sickle Cell Disease.
Topics: Anemia, Sickle Cell; Combined Modality Therapy; Glutamine; Humans | 2018 |
New and experimental agents for sickle cell disease.
Topics: Anemia, Sickle Cell; Antisickling Agents; Combined Modality Therapy; Drug Discovery; Erythrocyte Transfusion; Glutamine; Humans; Hydroxyurea | 2018 |
A Phase 3 Trial of l-Glutamine in Sickle Cell Disease.
Topics: Anemia, Sickle Cell; Glutamine; Humans | 2018 |
A Phase 3 Trial of l-Glutamine in Sickle Cell Disease.
Topics: Anemia, Sickle Cell; Glutamine; Humans | 2018 |
A Phase 3 Trial of l-Glutamine in Sickle Cell Disease.
Topics: Anemia, Sickle Cell; Glutamine; Humans | 2018 |
Sickle cell disease: a new era.
Topics: Anemia, Sickle Cell; Child; Cost of Illness; Global Health; Glutamine; Humans | 2019 |
Erythrocyte glutamine depletion, altered redox environment, and pulmonary hypertension in sickle cell disease.
Topics: Adolescent; Adult; Anemia, Sickle Cell; Echinococcosis, Pulmonary; Erythrocytes; Female; Glutamic Acid; Glutamine; Hemolysis; Humans; Hydrogen-Ion Concentration; Male; NADP; Nitric Oxide; Oxidation-Reduction; Tricuspid Valve Insufficiency | 2008 |
Retroviral transfer of a human beta-globin/delta-globin hybrid gene linked to beta locus control region hypersensitive site 2 aimed at the gene therapy of sickle cell disease.
Topics: 3T3 Cells; Alanine; Amino Acid Sequence; Anemia, Sickle Cell; Animals; Base Sequence; Conserved Sequence; Gene Transfer Techniques; Genetic Therapy; Genetic Vectors; Globins; Glutamine; Hemoglobin, Sickle; Humans; Introns; Macromolecular Substances; Mice; Models, Structural; Molecular Sequence Data; Phosphoglycerate Kinase; Protein Multimerization; Recombination, Genetic; Retroviridae; Sequence Homology, Amino Acid | 1995 |
Protein and energy metabolism in prepubertal children with sickle cell anemia.
Topics: Amino Acids; Anemia, Sickle Cell; Basal Metabolism; Calorimetry, Indirect; Case-Control Studies; Child; Energy Metabolism; Female; Glutamine; Humans; Infusions, Intravenous; Male; Proteins; Puberty; Reticulocytes | 1996 |
Increased red cell glutamine availability in sickle cell anemia: demonstration of increased active transport, affinity, and increased glutamate level in intact red cells.
Topics: Anemia, Sickle Cell; Biological Transport, Active; Erythrocytes; Glutamic Acid; Glutamine; Humans; Kinetics; NAD | 1997 |
A comparison in normal individuals and sickle cell patients of reduced glutathione precursors and their transport between plasma and red cells.
Topics: Adult; Amino Acid Transport System ASC; Amino Acid Transport System L; Anemia, Sickle Cell; Biological Transport; Carbon Monoxide; Cysteine; Enzyme Inhibitors; Erythrocytes; Female; Glutamic Acid; Glutamine; Glutathione; Glycine; Humans; Male; Middle Aged; Oxygen; Protein Kinase Inhibitors; Protein Kinases; Serine; Staurosporine | 2000 |
Inhibition of sickling in erythrocytes by amino acids.
Topics: Amino Acids; Anemia, Sickle Cell; Asparagine; Erythrocytes; Glutamine; Hemoglobin, Sickle; Homoserine; Humans | 1975 |
An in vitro method for screening compounds for the effect on the rate of sickling of erythrocytes.
Topics: 2-Hydroxyphenethylamine; Anemia, Sickle Cell; Aniline Compounds; Antisickling Agents; Calcium; Erythrocyte Membrane; Erythrocytes; Ethanolamines; Glutamine; Humans; Methods; Oxygen; Procaine | 1976 |