glutamine has been researched along with Colorectal Cancer in 69 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 1 (1.45) | 18.7374 |
1990's | 3 (4.35) | 18.2507 |
2000's | 12 (17.39) | 29.6817 |
2010's | 31 (44.93) | 24.3611 |
2020's | 22 (31.88) | 2.80 |
Authors | Studies |
---|---|
Hua, Q; Lin, Z; Ren, J; Wang, H; Wang, L; Xu, G; Yu, D; Zhang, B; Zhang, D; Zhang, T; Zhao, L | 1 |
Liu, J; Song, M | 1 |
Cong, X; Liu, C; Sun, H; Wang, X; Zhang, C; Zheng, Y | 1 |
Inoue, H; Kageyama, S; Kawauchi, A; Kim, CJ; Minami, K; Shirasawa, S; Tambe, Y; Tanaka, H; Terado, T; Tsunoda, T; Ushio, A | 1 |
Kong, P; Liu, F; Tang, S; Wang, Q; Wu, R | 1 |
Chen, B; Fu, W; Gaiddon, C; Gross, I; Han, X; Hou, L; Hou, Y; Li, L; Liang, Y; Long, B; Meng, X; Pang, W; Wang, L; Wang, Y; Xu, C; Yao, H; Zhang, X; Zhong, T; Zhou, K | 1 |
Chen, JK; Huang, CY; Kuo, WT | 1 |
Baiocco, G; Guardamagna, I; Iaria, O; Ivaldi, GB; Liotta, M; Lonati, L; Maggi, M; Mentana, A; Pessino, G; Previtali, A; Scotti, C; Tabarelli de Fatis, P; Uggè, V | 1 |
Achaintre, D; Adamski, J; Amiano, P; Ardanaz, E; Bešević, J; Boutron-Ruault, MC; Breeur, M; Bueno-de-Mesquita, B; Chadeau-Hyam, M; Colorado-Yohar, S; Cross, AJ; Dahm, CC; Derksen, JWG; Dimou, N; Eichelmann, F; Eriksen, AK; Ferrari, P; Gicquiau, A; Gunter, MJ; Huybrechts, I; Jenab, M; Kaaks, R; Katzke, V; Keun, H; Murphy, N; Nøst, TH; Overvad, K; Palli, D; Pasanisi, F; Prehn, C; Rinaldi, S; Rothwell, JA; Sánchez, MJ; Sandanger, TM; Scalbert, A; Schulze, MB; Severi, G; Skeie, G; Smith-Byrne, K; Tjønneland, A; Travis, R; Tsilidis, KK; Tumino, R; van Guelpen, B; Viallon, V; Vidman, L; Vineis, P; Wedekind, R; Zamora-Ros, R | 1 |
Bae, SW; Cohen, AS; Geng, L; Georgiou, DK; Manning, HC; Tantawy, MN; Wang, J; Wen, X | 1 |
Chen, B; Li, Y; Lu, W; Luan, T; Sun, J; Tu, L; Zhang, R | 1 |
Chang, C; Chen, X; Hu, Y; Li, K; Ye, J | 1 |
Bao, T; Chen, J; Li, G; Li, P; Xiong, K; Yang, X; Zhang, Y | 1 |
Dai, W; Han, D; Mo, W; Xu, W; Xu, X | 1 |
Chen, H; Ding, YQ; Gao, JW; Han, Y; Hu, SS; Tan, TY; Wang, L; Wang, S; Wang, YQ; Yang, MH; Zhao, L | 1 |
Hara, Y; Hayashi, N; Masuko, K; Masuko, T; Minami, Y; Ueda, S; Yamasaki, A; Yoshimoto, S | 1 |
Brunengraber, H; Chen, V; Conlon, RA; Croniger, C; Fearon, E; Feng, Y; Hao, Y; Markowitz, S; Puchowicz, M; Wang, L; Wang, Z; Zhao, X; Zhao, Y | 1 |
Kang, MJ; Kim, MJ; Lee, SG; Noh, JY; Park, JM; Pyun, JC; Yoo, BC; Yun, TG | 1 |
Chou, YJ; Kober, KM; Kuo, CH; Kuo, TC; Liang, JT; Miaskowski, C; Shun, SC; Tseng, YJ; Yeh, KH | 1 |
Bian, X; Chan, LS; Chen, H; Gou, H; Ji, F; Kang, W; Li, W; Liu, D; Qian, Y; Shirasawa, S; Sung, JJ; Wong, CC; Wu, JL; Xu, J; Yat Luk, ST; Yu, J; Zhou, Q | 1 |
Edwards, RA; Habowski, AN; Hanse, EA; Ishak Gabra, MB; Kong, M; Li, H; Liao, SY; Lowman, XH; Ooi, AM; Tran, TQ; Waterman, ML; Yang, Y | 1 |
Barry, ST; Brown, G; Bunch, J; Bushell, M; Campbell, AD; Ceteci, F; Clark, W; Critchlow, SE; Dexter, A; Dunne, PD; Fey, SK; Gay, DM; Gilroy, K; Goodwin, RJA; Gottlieb, E; Hall, H; Hamm, G; Hedley, A; Jackstadt, R; Johnson, ER; Knight, JRP; Leach, JDG; Lewis, DY; Mackay, GM; Malla, SB; Malviya, G; Mrowinska, A; Murta, T; Najumudeen, AK; Nikula, CJ; Nixon, C; Race, AM; Ridgway, RA; Rodriguez-Blanco, G; Sansom, OJ; Solovyev, D; Steven, RT; Strathdee, D; Sumpton, D; Takats, Z; Tardito, S; Vlahov, N | 1 |
Cai, C; Tang, C; Xin, H; Zeng, B; Zeng, J | 1 |
Cheon, JH; Hong, SP; Il Kim, T; Kang, JY; Kim, JH; Kim, WH; Kwon, JH; Lee, HJ; Lee, KJ; Park, SJ; Seo, Y; Yoon, JP | 1 |
Chin, KF; Golkhalkhali, B; Paliany, AS; Rajandram, R | 1 |
Chen, YX; Fang, JY; Fu, LN; Gao, QY; Sun, DF; Tan, J; Wang, HL; Wang, JL; Wang, YQ; Xu, J; Zou, TH | 1 |
Hu, M; Liu, L; Yao, W | 1 |
Baumann, J; Baumann, M; Brockmeier, U; Classen, F; Göpelt, K; Kranz, P; Metzen, E; Pompsch, M; Riffkin, H; Wolf, A | 1 |
Lai, M; Li, J; Qi, LW; Wang, H; Zhu, Y | 1 |
Chang, PH; Chou, WC; Fan, CW; Huang, JS; Ling, HH; Pan, YP; Tseng, WK; Wang, CH; Wu, TH; Yeh, KY | 1 |
Wang, G; Wang, JJ; Wang, YZ; Xu, K; Yin, PH; Yu, Y | 1 |
Ji, G; Li, N; Tian, Y; Wang, K; Wang, Z | 1 |
Cai, G; Cai, S; Chen, T; Cheng, Y; Dong, T; Feng, B; Hu, X; Jia, W; Qiu, Y; Tan, B; Xie, G; Xu, LX; Zhang, M; Zhang, Y; Zhao, A; Zhao, L; Zheng, M; Zhou, Z; Zou, X | 1 |
Chihara, Y; Eto, S; Kato, Y; Kobayashi, T; Kuniyasu, H; Luo, Y; Miyano, H; Ohmori, H; Sasahira, T; Sasaki, T; Shimbo, K; Yoneda, J | 1 |
Li, Z; Wang, Y; Wu, H; Yang, P; Zhang, L | 1 |
Akagi, Y; Matono, K; Ogata, Y; Shirouzu, K; Tsuda, H; Uchida, S; Ushijima, M | 1 |
Cai, C; Chen, R; Fu, Z; Gong, Y; Han, F; Li, Y; Li, Z; Lin, Q; Liu, G; Tang, C; Yang, B; Ye, H; Ye, L; Yu, M; Zeng, B; Zhao, X; Zhou, Q; Zhou, Y; Zhu, J | 1 |
Colvin, H; Doki, Y; Hamabe, A; Hata, T; Ishii, H; Kawamoto, K; Konno, M; Koseki, J; Miyo, M; Mizushima, T; Mori, M; Nishida, N; Nishimura, J; Ogawa, H; Takemasa, I; Uemura, M; Yamamoto, H | 1 |
Chu, D; Guo, Y; Li, J; Li, X; Liu, X; Shen, L; Sun, X; Wei, L; Xu, X; Yang, G; Yao, L; Zhang, J | 1 |
Bhalla, K; Boros, LG; Boxer, MB; DeBerardinis, RJ; Dewi, R; Drapkin, R; Duraisamy, S; Girnun, GD; Gordon, C; Hwang, BJ; Liu, WJ; Montal, ED; Ou, L; Powers, RS; Rohde, JM; Ropell, AE; Shroyer, KR; Sudderth, J; Twaddel, W; Wong, KK | 1 |
Chang, PH; Chen, CH; Chou, WC; Fan, CW; Huang, JS; Pan, YP; Tseng, WK; Wang, CH; Yeh, KY | 1 |
Chen, XP; Huang, JP; Jiang, XW; Wang, QZ | 1 |
Chiang, BH; Chiu, HM; Huang, YT; Lin, YW | 1 |
Chen, X; Cheng, J; Huang, G; Liu, C; Liu, X; Peng, Z; Yu, F; Yuan, C | 1 |
Fan, Y; Ji, G; Li, J; Sun, L; Tian, Y; Wang, J; Wang, K; Wang, L; Wang, Y; Wang, Z; Ye, Y | 1 |
Brunengraber, H; Cao, B; Conlon, RA; Dong, B; Feng, X; Fink, S; Guan, BJ; Hao, Y; Hatzoglou, M; Jin, Z; Kinzler, KW; Krokowski, D; LaFramboise, T; Li, Q; Markowitz, S; Meropol, NJ; Samuels, Y; Velculescu, VE; Vogelstein, B; Wang, C; Wang, Z; Willis, JE; Xiang, M; Xu, C; Xu, Y; Zhang, GF | 1 |
Hasegawa, S; Inamoto, S; Iwamoto, M; Kawada, K; Sakai, Y; Sasazuki, T; Shirasawa, S; Toda, K | 1 |
Asai, A; Colvin, H; Doki, Y; Haraguchi, N; Hata, T; Ishii, H; Kawamoto, K; Konno, M; Koseki, J; Mizushima, T; Mori, M; Nishida, N; Nishimura, J; Satoh, T; Takahashi, H; Tsunekuni, K | 1 |
Ci, Y; Hu, Y; Huang, F; Hui, K; Shi, L; Xu, C; Yang, Y; Zhang, Q; Zhao, J; Zhou, R | 1 |
Busch, EL; Fargo, DC; Huang, W; Ji, M; Jin, A; Keku, TO; Lewis, D; Li, L; Li, X; Ren, NSX; Sandler, RS; Tokar, EJ; Wu, WKK; Xu, X; Zhang, Y | 1 |
Inoue, N; Kasahara, M; Miyaishi, A; Osawa, K; Osawa, Y; Shimada, E; Tabuchi, Y; Takahashi, J; Tanaka, K; Tsutou, A; Yamamoto, M; Yoshida, K | 1 |
Li, J; Li, Y; Liu, F; Ni, X; Ping, X; Yu, B | 1 |
Gunduz, M; Mita, Y; Naomoto, Y; Ouchida, M; Sakai, A; Shimizu, K; Tanabe, S; Toyooka, S; Yamamoto, H; Yasuda, Y | 1 |
Engin, A; Engin, AB; Karahalil, B; Karakaya, AE | 1 |
Aghasadeghi, MR; Amanlou, M; Ardestani, MS; Ebrahimi, SE; Mehravi, B; Nourmohammadi, Z; Omoomi, FD; Pourhosseini, S; Rahimi, P; Siadat, SD; Tabasi, MA | 1 |
Matono, K; Ogata, Y; Shirouzu, K | 1 |
Ansari, R; Cheng, L; Helft, P; Juliar, B; Loehrer, P; Pan, CX; Pletcher, W; Seitz, D; Sweeney, C; Vinson, J | 1 |
Cai, JL; Chen, R; Jiang, AF; Zhou, B | 1 |
Antonione, R; Barazzoni, R; Biolo, G; Ciocchi, B; Dal Mas, V; De Cicco, M; Dore, F; Guarnieri, G; Lorenzon, S; Zanetti, M | 1 |
Boelens, PG; Dejong, CH; Deutz, NE; Melis, GC; Siroen, MP; Soeters, PB; van de Poll, MC; van Leeuwen, PA | 1 |
Chen, PM; Chen, WS; Chiou, TJ; Jiang, JK; Lin, JK; Lin, TC; Liu, JH; Wang, HS; Wang, WS; Yen, CC | 1 |
Benais-Pont, G; Buchegger, F; Dupertuis, YM; Pichard, C | 1 |
O'Dwyer, ST | 1 |
Halliday, MI; Hamilton, PW; Rowlands, BJ; Williamson, KE | 1 |
Powell-Tuck, J | 1 |
Buhl, K; Decker-Baumann, C; Dueck, M; Frohmüller, S; Schlag, PM; von Herbay, A | 1 |
Bode, BP; Pawlik, TM; Souba, WW; Sweeney, TJ | 1 |
Abdel-Rahman, SZ; Bondy, ML; El-Badawy, SA; Khaled, HM; Levin, B; Omar, S; Seifeldin, IA; Soliman, AS | 1 |
Crone, C; Eggstein, S; Farthmann, EH; Imdahl, A | 1 |
3 review(s) available for glutamine and Colorectal Cancer
Article | Year |
---|---|
Comparative Effects of Different Nutritional Supplements on Inflammation, Nutritional Status, and Clinical Outcomes in Colorectal Cancer Patients: A Systematic Review and Network Meta-Analysis.
Topics: Arginine; Colorectal Neoplasms; Dietary Supplements; Fatty Acids, Omega-3; Glutamine; Humans; Inflammation; Network Meta-Analysis; Nutritional Status | 2023 |
Effects of glutamine on plasma protein and inflammation in postoperative patients with colorectal cancer: a meta-analysis of randomized controlled trials.
Topics: Albumins; Colorectal Neoplasms; Glutamine; Humans; Inflammation; Randomized Controlled Trials as Topic; Tumor Necrosis Factor-alpha | 2023 |
The Roles of Adjuvant Supplements in Colorectal Cancer Patients on Chemotherapy - Reaping Benefits from Metabolic Crosstalk.
Topics: Antineoplastic Agents; Colorectal Neoplasms; Dietary Supplements; Fatty Acids, Omega-3; Glutamine; Humans; Probiotics | 2018 |
9 trial(s) available for glutamine and Colorectal Cancer
Article | Year |
---|---|
Randomized phase II study of 5-fluorouracil hepatic arterial infusion with or without antineoplastons as an adjuvant therapy after hepatectomy for liver metastases from colorectal cancer.
Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Benzeneacetamides; Chemotherapy, Adjuvant; Colorectal Neoplasms; Drug Combinations; Fluorouracil; Glutamine; Hepatectomy; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Middle Aged; Phenylacetates; Piperidones; Survival Analysis; Treatment Outcome | 2015 |
[Effects of Couplet Medicines (Astragalus Membranaceus and Jiaozhen) on Intestinal Barrier in Postoperative Colorectal Cancer Patients].
Topics: Amine Oxidase (Copper-Containing); Antineoplastic Combined Chemotherapy Protocols; Astragalus propinquus; Chemotherapy, Adjuvant; Colorectal Neoplasms; Drugs, Chinese Herbal; Glutamine; Humans; Intestinal Mucosa; Intestines; Lactic Acid; Tumor Necrosis Factor-alpha | 2015 |
Clinical trial: prophylactic intravenous alanyl-glutamine reduces the severity of gastrointestinal toxicity induced by chemotherapy--a randomized crossover study.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Dipeptides; Double-Blind Method; Female; Glutamine; Humans; Infusions, Intravenous; Male; Middle Aged; Stomach Neoplasms | 2009 |
A phase II trial of irinotecan, 5-fluorouracil and leucovorin combined with celecoxib and glutamine as first-line therapy for advanced colorectal cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Celecoxib; Colorectal Neoplasms; Cyclooxygenase Inhibitors; Diarrhea; Disease-Free Survival; Drug Administration Schedule; Female; Fluorouracil; Glutamine; Humans; Irinotecan; Leucovorin; Male; Middle Aged; Pyrazoles; Sulfonamides; Treatment Outcome | 2005 |
[Effect of immune-enhanced enteral diet on postoperative immunological function in patients with colorectal cancer].
Topics: Adult; Aged; Aged, 80 and over; Arginine; Colorectal Neoplasms; Enteral Nutrition; Fatty Acids, Omega-3; Female; Glutamine; Humans; Male; Middle Aged; Postoperative Period | 2005 |
Response of muscle protein and glutamine kinetics to branched-chain-enriched amino acids in intensive care patients after radical cancer surgery.
Topics: Amino Acids, Branched-Chain; Blood Glucose; Colorectal Neoplasms; Colorectal Surgery; Critical Care; Cross-Over Studies; Dose-Response Relationship, Drug; Female; Glutamine; Humans; Infusions, Intravenous; Insulin; Leg; Leucine; Male; Middle Aged; Muscle Proteins; Plethysmography; Uterine Cervical Neoplasms | 2006 |
Oral glutamine is effective for preventing oxaliplatin-induced neuropathy in colorectal cancer patients.
Topics: Adenocarcinoma; Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Chi-Square Distribution; Colorectal Neoplasms; Female; Fluorouracil; Glutamine; Humans; Leucovorin; Male; Middle Aged; Nervous System Diseases; Neuroprotective Agents; Organoplatinum Compounds; Oxaliplatin; Pilot Projects; Treatment Outcome | 2007 |
Total parenteral nutrition with glutamine dipeptide shortened hospital stays and improved immune status and nitrogen economy after major abdominal surgery.
Topics: Adult; Aged; Aged, 80 and over; Colorectal Neoplasms; Female; Glutamine; Humans; Male; Middle Aged; Parenteral Nutrition, Total; Postoperative Care; Randomized Controlled Trials as Topic; Treatment Outcome | 1999 |
Reduction of chemotherapy-induced side-effects by parenteral glutamine supplementation in patients with metastatic colorectal cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Female; Fluorouracil; Glutamine; Humans; Infusions, Parenteral; Intestinal Mucosa; Leucovorin; Male; Middle Aged; Prospective Studies | 1999 |
57 other study(ies) available for glutamine and Colorectal Cancer
Article | Year |
---|---|
CEMIP, a novel adaptor protein of OGT, promotes colorectal cancer metastasis through glutamine metabolic reprogramming via reciprocal regulation of β-catenin.
Topics: Amino Acid Transport System A; Amino Acid Transport System ASC; Animals; beta Catenin; Cell Line, Tumor; Cell Nucleus; Colorectal Neoplasms; Female; Gene Expression Regulation, Neoplastic; Glutamine; HCT116 Cells; Humans; Hyaluronoglucosaminidase; Mice; Minor Histocompatibility Antigens; N-Acetylglucosaminyltransferases; Neoplasm Metastasis; Neoplasm Transplantation; Transcription, Genetic | 2021 |
Circ_0067717 promotes colorectal cancer cell growth, invasion and glutamine metabolism by serving as a miR-497-5p sponge to upregulate SLC7A5.
Topics: Animals; Cell Proliferation; Cell Transformation, Neoplastic; Colorectal Neoplasms; Disease Models, Animal; Glutamine; Humans; Large Neutral Amino Acid-Transporter 1; MicroRNAs | 2023 |
Glutamine deficiency promotes recurrence and metastasis in colorectal cancer through enhancing epithelial-mesenchymal transition.
Topics: Carcinoembryonic Antigen; Colorectal Neoplasms; Epithelial-Mesenchymal Transition; Glutamine; Humans; Prognosis | 2022 |
Cryptotanshinone suppresses tumorigenesis by inhibiting lipogenesis and promoting reactive oxygen species production in KRAS‑activated pancreatic cancer cells.
Topics: Carcinogenesis; Cell Line, Tumor; Cell Transformation, Neoplastic; Colorectal Neoplasms; Glutamine; Humans; Lipids; Lipogenesis; Pancreatic Neoplasms; Phenanthrenes; Proto-Oncogene Proteins p21(ras); Reactive Oxygen Species; Signal Transduction | 2022 |
Hsa_circ_0003602 Contributes to the Progression of Colorectal Cancer by Mediating the miR-149-5p/SLC38A1 Axis.
Topics: Amino Acid Transport System A; Animals; Cell Proliferation; Colorectal Neoplasms; Disease Models, Animal; Glutamine; Humans; MicroRNAs | 2023 |
Anti-tumor effects of P-LPK-CPT, a peptide-camptothecin conjugate, in colorectal cancer.
Topics: Amino Acid Transport System ASC; Camptothecin; Colorectal Neoplasms; Glutamine; Humans; Minor Histocompatibility Antigens; Molecular Docking Simulation; Peptides | 2022 |
Glutamine induces remodeling of tight junctions in Caco-2 colorectal cancer cell.
Topics: Caco-2 Cells; Colorectal Neoplasms; Glucose; Glutamine; Humans; Tight Junctions | 2022 |
Asparagine and Glutamine Deprivation Alters Ionizing Radiation Response, Migration and Adhesion of a p53
Topics: Asparaginase; Asparagine; Caco-2 Cells; Cell Line, Tumor; Colonic Neoplasms; Colorectal Neoplasms; Glutamine; Humans; Radiation, Ionizing; Tumor Suppressor Protein p53 | 2023 |
Circulating amino acid levels and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition and UK Biobank cohorts.
Topics: Amino Acids; Biological Specimen Banks; Colorectal Neoplasms; Glutamine; Histidine; Humans; Prospective Studies; United Kingdom | 2023 |
Feasibility of [
Topics: Animals; Colorectal Neoplasms; Disease Models, Animal; ErbB Receptors; Feasibility Studies; Glutamates; Glutaminase; Glutamine; Humans; Mice; Positron-Emission Tomography; Proto-Oncogene Proteins p21(ras) | 2023 |
Constructing interactive networks of functional genes and metabolites to uncover the cellular events related to colorectal cancer cell migration induced by arsenite.
Topics: Arsenites; Cell Line, Tumor; Cell Movement; Colorectal Neoplasms; Epithelial-Mesenchymal Transition; Glutamine; Humans | 2023 |
Systematic analysis of glutamine metabolism family genes and exploration of the biological role of GPT in colorectal cancer.
Topics: Colorectal Neoplasms; Databases, Factual; Epithelial Cells; Glutamine; Humans; Oncogenes; Prognosis; Tumor Microenvironment | 2023 |
SLC25A21 downregulation promotes KRAS-mutant colorectal cancer progression by increasing glutamine anaplerosis.
Topics: Cell Line, Tumor; Colorectal Neoplasms; Down-Regulation; Glutamine; Guanosine Triphosphate; Humans; Proto-Oncogene Proteins p21(ras) | 2023 |
Anti-tumor effects of an antagonistic mAb against the ASCT2 amino acid transporter on KRAS-mutated human colorectal cancer cells.
Topics: Amino Acid Transport System ASC; Animals; Antibodies, Monoclonal; Antineoplastic Agents; Cell Line, Tumor; Colorectal Neoplasms; Female; Gene Knockout Techniques; Glutamine; HEK293 Cells; Humans; Mice; Minor Histocompatibility Antigens; Molecular Targeted Therapy; Mutation; Proto-Oncogene Proteins p21(ras); Xenograft Model Antitumor Assays | 2020 |
Colorectal cancers utilize glutamine as an anaplerotic substrate of the TCA cycle in vivo.
Topics: Animals; Carbon Isotopes; Citric Acid Cycle; Class I Phosphatidylinositol 3-Kinases; Colorectal Neoplasms; Female; Glutamine; HCT116 Cells; Humans; Kinetics; Mice, Nude; Mutation; Subcutaneous Tissue; Substrate Specificity; Xenograft Model Antitumor Assays | 2019 |
Simultaneous Analysis of Multiple Cancer Biomarkers Using MALDI-TOF Mass Spectrometry Based on a Parylene-Matrix Chip.
Topics: Bile Duct Neoplasms; Biomarkers, Tumor; Cholangiocarcinoma; Colorectal Neoplasms; Equipment Design; Glutamine; Humans; Limit of Detection; Lysophosphatidylcholines; Polymers; Pyridones; Reproducibility of Results; Solubility; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Xylenes | 2020 |
A Pilot Study of Metabolomic Pathways Associated With Fatigue in Survivors of Colorectal Cancer.
Topics: Aged; Cancer Survivors; Colorectal Neoplasms; Fatigue; Female; Glutamic Acid; Glutamine; Glutathione; Humans; Male; Metabolic Networks and Pathways; Metabolomics; Middle Aged; Pilot Projects; Surveys and Questionnaires; Taiwan | 2021 |
In Colorectal Cancer Cells With Mutant KRAS, SLC25A22-Mediated Glutaminolysis Reduces DNA Demethylation to Increase WNT Signaling, Stemness, and Drug Resistance.
Topics: Animals; Colon; Colorectal Neoplasms; DNA Demethylation; Drug Resistance, Neoplasm; Female; Fluorouracil; Follow-Up Studies; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Glutamine; Hong Kong; Humans; Intestinal Mucosa; Kaplan-Meier Estimate; Ketoglutaric Acids; Male; Mice, Knockout; Mitochondrial Membrane Transport Proteins; Neoplastic Stem Cells; Proto-Oncogene Proteins p21(ras); Wnt Signaling Pathway; Xenograft Model Antitumor Assays | 2020 |
α-Ketoglutarate attenuates Wnt signaling and drives differentiation in colorectal cancer.
Topics: Colorectal Neoplasms; Glutamine; Humans; Ketoglutaric Acids; Organoids; Tumor Microenvironment; Wnt Signaling Pathway | 2020 |
The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer.
Topics: 5' Untranslated Regions; Amino Acid Transport System ASC; Animals; Carcinogenesis; Cell Proliferation; Colorectal Neoplasms; Gene Expression Regulation, Neoplastic; Glutamine; Humans; Intestinal Mucosa; Kaplan-Meier Estimate; Large Neutral Amino Acid-Transporter 1; Mechanistic Target of Rapamycin Complex 1; Mice, Inbred C57BL; Minor Histocompatibility Antigens; Mutation; Neoplasm Metastasis; Oncogenes; Proto-Oncogene Proteins p21(ras); RNA, Messenger; Signal Transduction; TOR Serine-Threonine Kinases | 2021 |
[Effect of ASCT2 gene knock-down by shRNA on biological behaviors of colorectal cancer cells].
Topics: Amino Acid Transport System ASC; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Down-Regulation; Gene Knockdown Techniques; Glutamine; Humans; Minor Histocompatibility Antigens; Neoplasm Invasiveness; Oncogenes; RNA, Messenger; RNA, Small Interfering; Transfection | 2017 |
Effects of metformin on colorectal cancer stem cells depend on alterations in glutamine metabolism.
Topics: Adenylate Kinase; Animals; Benzophenanthridines; Cell Line, Tumor; Colorectal Neoplasms; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Glucose; Glutamine; HT29 Cells; Humans; Metformin; Mice; Neoplasm Transplantation; Neoplastic Stem Cells; Oxygen Consumption; Ribosomal Protein S6 Kinases | 2018 |
Sirtuin5 contributes to colorectal carcinogenesis by enhancing glutaminolysis in a deglutarylation-dependent manner.
Topics: Carcinogenesis; Cell Proliferation; Citric Acid Cycle; Colorectal Neoplasms; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Glutamate Dehydrogenase; Glutamine; HCT116 Cells; Humans; RNA Interference; Sirtuins | 2018 |
Activation of p53 by costunolide blocks glutaminolysis and inhibits proliferation in human colorectal cancer cells.
Topics: Antineoplastic Agents, Phytogenic; Cell Nucleus; Cell Proliferation; Cell Survival; Colorectal Neoplasms; Gene Expression Regulation, Neoplastic; Glutaminase; Glutamine; HCT116 Cells; Humans; Phosphorylation; Protein Transport; Sesquiterpenes; Time Factors; TOR Serine-Threonine Kinases; Tumor Suppressor Protein p53 | 2018 |
Autophagy induced by ionizing radiation promotes cell death over survival in human colorectal cancer cells.
Topics: Apoptosis; Autophagy; Autophagy-Related Protein 7; Beclin-1; Cell Hypoxia; Cell Line, Tumor; Colorectal Neoplasms; Glutamine; Humans; Oxygen; Radiation, Ionizing | 2019 |
Tyrosine and Glutamine-Leucine Are Metabolic Markers of Early-Stage Colorectal Cancers.
Topics: Aged; Biomarkers, Tumor; Case-Control Studies; Colorectal Neoplasms; Dipeptides; Female; Glutamine; Humans; Leucine; Male; Metabolic Syndrome; Metabolomics; Middle Aged; Neoplasm Staging; Principal Component Analysis; Spectrometry, Mass, Electrospray Ionization; Tyrosine | 2019 |
Clinical Significance of Serum Glutamine Level in Patients with Colorectal Cancer.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Albumins; Biomarkers, Tumor; C-Reactive Protein; Carcinoembryonic Antigen; Colorectal Neoplasms; Cytokines; Disease Progression; Female; Glutamine; Humans; Inflammation; Male; Middle Aged; Multivariate Analysis; Neoplasm Staging; Prognosis; Retrospective Studies; Survival Analysis; Young Adult | 2019 |
Triterpenoids Extracted from
Topics: Animals; Apoptosis; Betulinic Acid; Cell Line, Tumor; Cell Proliferation; Chromatography, Liquid; Colorectal Neoplasms; Flavonoids; Gene Regulatory Networks; Glutamine; Glycolysis; Humans; Male; Metabolome; Mice; Mice, Inbred BALB C; Mice, Nude; Pentacyclic Triterpenes; Plant Extracts; Rhus; Tandem Mass Spectrometry; Triterpenes; Validation Studies as Topic; Xenograft Model Antitumor Assays | 2020 |
Chemopreventive effect of dietary glutamine on colitis-associated colon tumorigenesis in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Azoxymethane; Biomarkers, Tumor; Blotting, Western; Cell Proliferation; Cell Transformation, Neoplastic; Chemoprevention; Colitis; Colon; Colorectal Neoplasms; Cyclooxygenase 2; Dextran Sulfate; Dietary Supplements; Enzyme-Linked Immunosorbent Assay; Female; Glutamine; Immunohistochemistry; Male; Mice; Mice, Inbred BALB C; NF-kappa B; Nitric Oxide Synthase Type II; Real-Time Polymerase Chain Reaction; Rectum; Severity of Illness Index | 2013 |
Metabonomics identifies serum metabolite markers of colorectal cancer.
Topics: Adult; Aged; Biomarkers, Tumor; Carcinoembryonic Antigen; Case-Control Studies; Citric Acid Cycle; Colorectal Neoplasms; Discriminant Analysis; Fatty Acids; Female; Gas Chromatography-Mass Spectrometry; Glutamine; Humans; Least-Squares Analysis; Male; Metabolomics; Microbiota; Middle Aged; Neoplasm Staging; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Statistics, Nonparametric; Urea | 2013 |
Cancer usurps skeletal muscle as an energy repository.
Topics: Amino Acids; Animals; Autophagy; Cell Line, Tumor; Colorectal Neoplasms; Disease Models, Animal; Energy Metabolism; Glutamine; Heterografts; HMGB1 Protein; HT29 Cells; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Nude; Mitochondria, Muscle; Muscle, Skeletal; Recombinant Proteins | 2014 |
GRP78 enhances the glutamine metabolism to support cell survival from glucose deficiency by modulating the β-catenin signaling.
Topics: Animals; beta Catenin; Cadherins; Cell Survival; Colorectal Neoplasms; Dogs; Down-Regulation; Endoplasmic Reticulum Chaperone BiP; Glucose; Glutamine; Heat-Shock Proteins; HT29 Cells; Humans; Madin Darby Canine Kidney Cells; Proto-Oncogene Proteins c-myc; Signal Transduction; Transfection | 2014 |
Glutamate dehydrogenase is a novel prognostic marker and predicts metastases in colorectal cancer patients.
Topics: Aged; Biomarkers, Tumor; Cell Movement; Cell Proliferation; Colorectal Neoplasms; Disease Progression; Disease-Free Survival; Epithelial-Mesenchymal Transition; Female; Glutamate Dehydrogenase; Glutamine; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Metastasis; Prognosis; Proportional Hazards Models; Up-Regulation | 2015 |
Tumour-suppressive function of SIRT4 in human colorectal cancer.
Topics: Cell Movement; Cell Proliferation; Colorectal Neoplasms; Disease Progression; Genes, Tumor Suppressor; Glutamine; HCT116 Cells; HT29 Cells; Humans; Mitochondrial Proteins; Neoplasm Invasiveness; Prognosis; Sirtuins; Tumor Cells, Cultured | 2015 |
Tumor suppressor NDRG2 inhibits glycolysis and glutaminolysis in colorectal cancer cells by repressing c-Myc expression.
Topics: Amino Acid Transport System ASC; Animals; beta Catenin; Caco-2 Cells; Cell Proliferation; Colorectal Neoplasms; Down-Regulation; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Glucose; Glutaminase; Glutamine; Glycolysis; HCT116 Cells; HEK293 Cells; HT29 Cells; Humans; Lactic Acid; Male; Mice, Nude; Middle Aged; Minor Histocompatibility Antigens; Proto-Oncogene Proteins c-myc; RNA Interference; Signal Transduction; Time Factors; Transcription, Genetic; Transfection; Tumor Burden; Tumor Suppressor Proteins | 2015 |
PEPCK Coordinates the Regulation of Central Carbon Metabolism to Promote Cancer Cell Growth.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Glucose; Glutamine; Glycolysis; HT29 Cells; Humans; Mechanistic Target of Rapamycin Complex 1; Mice; Multiprotein Complexes; Neoplasm Transplantation; Phosphoenolpyruvate Carboxykinase (ATP); TOR Serine-Threonine Kinases | 2015 |
Relationship between pre-treatment nutritional status, serum glutamine, arginine levels and clinicopathological features in Taiwan colorectal cancer patients.
Topics: Aged; Aged, 80 and over; Arginine; Body Mass Index; C-Reactive Protein; Colorectal Neoplasms; Disease-Free Survival; Female; Glutamine; Humans; Hypoalbuminemia; Length of Stay; Male; Malnutrition; Middle Aged; Neoplasm Staging; Nutrition Assessment; Nutritional Status; Taiwan; Weight Loss | 2015 |
Curcumin Induces Apoptosis of Colorectal Cancer Stem Cells by Coupling with CD44 Marker.
Topics: Apoptosis; Cell Line, Tumor; Colorectal Neoplasms; Curcumin; Glutamine; Humans; Hyaluronan Receptors; Metabolome; Neoplastic Stem Cells | 2016 |
Clinical and therapeutic significance of sirtuin-4 expression in colorectal cancer.
Topics: Aged; Animals; Antimetabolites, Antineoplastic; Cell Survival; Colorectal Neoplasms; Drug Resistance, Neoplasm; Female; Fluorouracil; Gene Expression; Glutamine; HT29 Cells; Humans; Inhibitory Concentration 50; Kaplan-Meier Estimate; Male; Mice, Inbred BALB C; Mice, Nude; Middle Aged; Mitochondrial Proteins; Multivariate Analysis; Neoplasm Transplantation; Prognosis; Proportional Hazards Models; Sirtuins | 2016 |
Chemopreventive Effect of Dietary Glutamineon Colitis-Associated Colorectal Cancer Is Associated with Modulation of the DEPTOR/mTOR Signaling Pathway.
Topics: Animals; Colitis; Colorectal Neoplasms; Diet; Gene Expression Regulation; Glutamine; Humans; Intracellular Signaling Peptides and Proteins; Mice; Signal Transduction; TOR Serine-Threonine Kinases | 2016 |
Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer.
Topics: Activating Transcription Factor 4; Adenocarcinoma; Adenosine Triphosphate; Aminooxyacetic Acid; Animals; Antineoplastic Agents; Cell Line, Tumor; Citric Acid Cycle; Class I Phosphatidylinositol 3-Kinases; Colorectal Neoplasms; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Glutamine; HCT116 Cells; HT29 Cells; Humans; Ketoglutaric Acids; Mice; Mice, Nude; Mutation; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Signal Transduction; Transaminases; Tumor Burden; Xenograft Model Antitumor Assays | 2016 |
Metabolic Alterations Caused by KRAS Mutations in Colorectal Cancer Contribute to Cell Adaptation to Glutamine Depletion by Upregulation of Asparagine Synthetase.
Topics: Adaptation, Biological; Amino Acids; Animals; Aspartate-Ammonia Ligase; Cell Line, Tumor; Colorectal Neoplasms; Disease Models, Animal; Female; Glutamine; Heterografts; Humans; Mice; Mutation; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; ras Proteins; Signal Transduction; TOR Serine-Threonine Kinases; Tumor Burden | 2016 |
Oncometabolite D-2-Hydroxyglurate Directly Induces Epithelial-Mesenchymal Transition and is Associated with Distant Metastasis in Colorectal Cancer.
Topics: Caco-2 Cells; Cell Line, Tumor; Colorectal Neoplasms; Epithelial-Mesenchymal Transition; Glutamine; Glutarates; HCT116 Cells; HEK293 Cells; Histones; HT29 Cells; Humans; Isocitrate Dehydrogenase; Mutation; Neoplasm Metastasis; Promoter Regions, Genetic; Zinc Finger E-box-Binding Homeobox 1 | 2016 |
Selenite inhibits glutamine metabolism and induces apoptosis by regulating GLS1 protein degradation via APC/C-CDH1 pathway in colorectal cancer cells.
Topics: Adenomatous Polyposis Coli Protein; Antigens, CD; Antineoplastic Agents; Apoptosis; Blotting, Western; Cadherins; Cell Line, Tumor; Colorectal Neoplasms; Fluorescent Antibody Technique; Gene Knockdown Techniques; Glutaminase; Glutamine; Humans; Immunohistochemistry; Immunoprecipitation; Real-Time Polymerase Chain Reaction; Selenious Acid; Signal Transduction | 2017 |
Haploinsufficiency of SIRT1 Enhances Glutamine Metabolism and Promotes Cancer Development.
Topics: Animals; Apoptosis; Carcinogenesis; Cell Proliferation; Colorectal Neoplasms; Glutamine; Haploinsufficiency; Humans; Mice; Mice, Knockout; Sirtuin 1 | 2017 |
Association of MUTYH Gln324His and APEX1 Asp148Glu with colorectal cancer and smoking in a Japanese population.
Topics: Aged; Asian People; Aspartic Acid; Case-Control Studies; Colorectal Neoplasms; DNA Glycosylases; DNA-(Apurinic or Apyrimidinic Site) Lyase; Female; Genetic Predisposition to Disease; Genotype; Glutamic Acid; Glutamine; Histidine; Humans; Male; Middle Aged; Polymorphism, Genetic; Smoking | 2008 |
Missense polymorphisms of PTPRJ and PTPN13 genes affect susceptibility to a variety of human cancers.
Topics: Adult; Aged; Aged, 80 and over; Arginine; Biomarkers, Tumor; Case-Control Studies; Colorectal Neoplasms; Esophageal Neoplasms; Female; Genetic Predisposition to Disease; Genotype; Glutamine; Head and Neck Neoplasms; Humans; Incidence; Isoleucine; Japan; Lung Neoplasms; Male; Methionine; Middle Aged; Neoplasms; Polymorphism, Single Nucleotide; Proline; Protein Tyrosine Phosphatase, Non-Receptor Type 13; Receptor-Like Protein Tyrosine Phosphatases, Class 3; Risk Factors | 2010 |
Oxidative stress, Helicobacter pylori, and OGG1 Ser326Cys, XPC Lys939Gln, and XPD Lys751Gln polymorphisms in a Turkish population with colorectal carcinoma.
Topics: Adult; Aged; Amino Acid Substitution; Colorectal Neoplasms; Cysteine; DNA Glycosylases; DNA-Binding Proteins; Genetics, Population; Glutamine; Helicobacter Infections; Helicobacter pylori; Humans; Lysine; Middle Aged; Mutation, Missense; Oxidative Stress; Polymorphism, Single Nucleotide; Serine; Turkey; Xeroderma Pigmentosum Group D Protein | 2010 |
Novel molecular anti-colorectalcancer conjugate:chlorambucil-adipic acid dihydrizide-glutamine.
Topics: Adipates; Animals; Antineoplastic Agents; Cell Death; Cell Proliferation; Cell Survival; Chlorambucil; Colorectal Neoplasms; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Glutamine; HT29 Cells; Humans; Mice; Molecular Structure; Molecular Targeted Therapy; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Tumor Cells, Cultured | 2013 |
[Anti-proliferative effects of biochemical defense modifier antineoplaston in colorectal carcinoma].
Topics: Animals; Apoptosis; Benzeneacetamides; Cell Cycle; Cell Cycle Proteins; Colorectal Neoplasms; Depression, Chemical; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Combinations; Glutamine; Humans; Lung Neoplasms; Mice; Mice, Nude; Phenylacetates; Piperidones; Tumor Cells, Cultured | 2003 |
Interorgan amino acid exchange in humans: consequences for arginine and citrulline metabolism.
Topics: Adult; Aged; Arginine; Blood Flow Velocity; Citrulline; Colorectal Neoplasms; Female; Glutamine; Hepatectomy; Humans; Intestine, Small; Kidney; Liver; Male; Middle Aged; Organ Specificity; Ornithine | 2007 |
Effect of an immunonutrient mix on human colorectal adenocarcinoma cell growth and viability.
Topics: Adenocarcinoma; Analysis of Variance; Apoptosis; Arginine; Caco-2 Cells; Cell Cycle; Cell Division; Cell Line, Tumor; Cell Survival; Colorectal Neoplasms; Dose-Response Relationship, Drug; Fatty Acids, Omega-3; Flow Cytometry; Glutamine; Growth Inhibitors; Humans; RNA | 2007 |
Glutamine supplementation in colorectal cancer.
Topics: Colorectal Neoplasms; Food, Formulated; Glutamine; Humans; Postoperative Complications; Time Factors; Treatment Outcome | 2007 |
Are bioavailable glutamine and sensitivity to hydrochloric acid DNA denaturation important colorectal tumour characteristics?
Topics: Adenocarcinoma; Adenoma, Villous; Bromodeoxyuridine; Cell Differentiation; Colorectal Neoplasms; DNA, Neoplasm; Glutamine; Humans; Tumor Cells, Cultured | 1994 |
Phorbol esters rapidly attenuate glutamine uptake and growth in human colon carcinoma cells.
Topics: Arginine; beta-Alanine; Biological Transport; Carcinogens; Cell Division; Colorectal Neoplasms; Glutamine; HT29 Cells; Humans; Intestinal Mucosa; Leucine; Protein Kinase C; Tetradecanoylphorbol Acetate | 2000 |
Inheritance of the 194Trp and the 399Gln variant alleles of the DNA repair gene XRCC1 are associated with increased risk of early-onset colorectal carcinoma in Egypt.
Topics: Adult; Age of Onset; Alleles; Amino Acid Sequence; Case-Control Studies; Colorectal Neoplasms; DNA; DNA Repair; DNA-Binding Proteins; Egypt; Female; Gene Frequency; Genetic Variation; Genotype; Glutamine; Humans; Male; Middle Aged; Odds Ratio; Pilot Projects; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Risk Factors; Rural Population; Tryptophan; Urban Population; X-ray Repair Cross Complementing Protein 1 | 2000 |
Growth of colorectal carcinoma cells: regulation in vitro by gastrin, pentagastrin and the gastrin-receptor antagonist proglumide.
Topics: Animals; Carcinoembryonic Antigen; Carcinoma; Cell Division; Colorectal Neoplasms; Gastrins; Glutamine; Humans; Mice; Pentagastrin; Proglumide; Receptors, Cholecystokinin; Tumor Cells, Cultured | 1989 |