Compounds > glutamine

glutamine and Cell Transformation, Neoplastic

glutamine has been researched along with Cell Transformation, Neoplastic in 84 studies

Research

Studies (84)

TimeframeStudies, this research(%)All Research%
pre-199019 (22.62)18.7374
1990's7 (8.33)18.2507
2000's9 (10.71)29.6817
2010's39 (46.43)24.3611
2020's10 (11.90)2.80

Authors

AuthorsStudies
Agnihotri, N; Kumar, S; Sharma, S1
Liu, J; Song, M1
Inoue, H; Kageyama, S; Kawauchi, A; Kim, CJ; Minami, K; Shirasawa, S; Tambe, Y; Tanaka, H; Terado, T; Tsunoda, T; Ushio, A1
Peng-Fei, S; Xiao-Xia, Y; Xiao-Yan, W; Xiu-Li, G; Zong-Xue, Z1
Chen, L; Dai, M; Guo, W; Li, R; Liang, Z; Liu, H; Liu, Q; Liu, X; Pang, J; Tong, WM; Wu, H; Zhang, H1
Chen, C; Chen, F; Chen, M; Deng, P; Hao, R; Li, J; Li, L; Luo, Y; Pi, H; Tan, M; Tang, B; Tian, L; Wang, H; Xie, J; Yu, Z; Yue, Y; Zhang, H; Zhao, Q; Zhou, Z1
Cheng, Q; Fu, S; Li, QI; Ren, P; Wang, W; Wu, NA1
Bezuidenhout, N; Shoshan, M1
Han, JM; Sung, Y; Yoo, HC; Yu, YC1
Cheng, XY; Lian, HF; Liu, CX; Liu, HY; Wang, W; Xue, F1
Berardi, D; Chiodi, I; Mondello, C; Perini, C1
Beattie, BJ; Bromberg, J; Burnazi, EM; Dunphy, MPS; Gerecitano, JF; Harding, JJ; Hsieh, JJ; Kelsen, DP; Kung, HF; Lewis, JS; Lyashchenko, SK; Mellinghoff, IK; Omuro, AM; Pressl, C; Staton, K; Venneti, S; Weber, W; Zanzonico, PB; Zhang, H1
Rubin, H1
Chiodi, I; Martino, C; Mondello, C; Picco, G1
Ji, G; Li, N; Tian, Y; Wang, K; Wang, Z1
Bar-Sagi, D; Commisso, C; Davidson, SM; Drebin, JA; Grabocka, E; Hackett, S; Kamphorst, JJ; Metallo, CM; Nofal, M; Parker, SJ; Rabinowitz, JD; Soydaner-Azeloglu, RG; Thompson, CB; Vander Heiden, MG1
Barosi, G; Campanelli, R; Catarsi, P; Massa, M; Poletto, V; Rosti, V; Vannucchi, AM; Villani, L1
Chun, MG; Shaw, RJ1
Dang, CV1
Chen, GJ; Guo, JY; Karsli-Uzunbas, G; Mathew, R; McMahon, M; Price, SM; Strohecker, AM; White, E1
Cerione, RA; Lukey, MJ; Wilson, KF1
Bjerkvig, R; Leenders, WP; Molenaar, R; Navis, AC; Niclou, SP; Tops, B; van Lith, SA; van Noorden, CJ; Verrijp, K; Wesseling, P1
Cerione, RA; DeBerardinis, RJ; Erickson, JW; Li, Y; McBrayer, MK; Ramachandran, S; Stalnecker, CA; Ulrich, SM1
Blyth, K; Cardaci, S; Edrada-Ebel, R; Frezza, C; Gaude, E; Gottlieb, E; Hedley, A; Jerby, L; Johnson, TI; Kalna, G; King, A; Leach, JD; MacKenzie, ED; Morrice, NA; Ruppin, E; Sciacovelli, M; Zheng, L1
Bae-Jump, VL; Guo, H; Jones, HM; Roque, DR; Sheng, X; Stine, JE; Willson, AK; Yuan, L; Zhou, C1
Djavaheri-Mergny, M; Durán, RV; Merhi, F; Villar, VH1
Aird, KM; Zhang, R1
Mostoslavsky, R; Sebastián, C1
Chang, S; Liu, M; Lv, J; Pang, X; Wang, J1
Chen, H; Li, C; Ma, Z; Zhang, G; Zhao, L1
Cerione, RA; Erickson, JW; Greene, KS; Lukey, MJ; Wilson, KF1
Cantrell, DA; Damerow, S; Grzes, KM; Pathak, S; Sinclair, LV; Swamy, M; van Aalten, DM1
Asara, JM; Beltz, S; Brown, KK; Camargo, FD; Chhangawala, S; Cohen, DE; Cox, AG; Evason, K; Galli, GG; Goessling, W; Houvras, Y; Hwang, KL; Lien, EC; Minami, A; Nissim, S; O'Connor, K; Stainier, DYR; Tsomides, A; Wucherpfennig, J; Yimlamai, D; Yuan, M1
Bartlebaugh, J; Bauer, MR; Bhutkar, A; Davidson, SM; Heimann, M; Jacks, T; Papagiannakopoulos, T; Subbaraj, L; Vander Heiden, MG1
Nagrath, D; Venneti, S; Yang, L1
Yuneva, M1
Amon, A; Glazier, CM; Housman, DE; Hunter, KE; Prabhu, VR; Whittaker, CA; Williams, BR1
Thompson, CB; Tong, X; Zhao, F1
Alberghina, L; Chiaradonna, F; Gaglio, D; Soldati, C; Vanoni, M1
Dang, CV; Gao, P; Le, A1
Mazurek, S1
Budinger, GR; Chandel, NS; Hamanaka, R; Joseph, J; Kalyanaraman, B; Lopez, M; Mutlu, GM; Weinberg, F; Weinberg, S; Wheaton, WW1
Barger, JF; Plas, DR1
Aguiló, JI; Anel, A; Charni, S; de Bettignies, G; Enriquez, JA; Haouzi, D; Hipskind, RA; Pardo, J; Rathore, MG; Sanchez-Beato, M; van den Elsen, PJ; Villalba, M1
Marie, SK; Shinjo, SM1
Alberghina, L; Balestrieri, C; Chiaradonna, F; Danna, LS; Gaglio, D; Gameiro, PA; Hiller, K; Metallo, CM; Stephanopoulos, G1
Belka, G; Chodosh, LA; Kung, HF; Lieberman, BP; Ploessl, K; Qu, W; Thompson, CB; Wang, L; Wise, DR; Zha, Z1
Chodosh, LA; Chodosh, LP; Divgi, CR; Kung, HF; Lieberman, BP; Oya, S; Ploessl, K; Qu, W; Thompson, CB; Wang, L; Wise, DR1
Guan, KL; Oermann, EK; Wu, J; Xiong, Y1
Allen, TD; Alonso, FJ; Bishop, JM; Chen, X; Fan, TW; Ferraris, DV; Higashi, RM; Matés, JM; Seo, Y; Tsukamoto, T; Wang, C; Yuneva, MO1
Daye, D; Wellen, KE1
Aeberhard, L; Eilers, M; Kempa, S; Kress, TR; Liu, L; Moll, R; Müller, J; Murphy, DJ; Muthalagu, N; Rudalska, R; Rycak, L; Ulbrich, J; Wüstefeld, T; Zender, L1
Kung, HF; Lieberman, BP; Ploessl, K; Qu, W; Wang, L1
Islam, A; Miller, DM; Muench, D; Sedoris, K; Thomas, SD1
Dimaio, D; Dixon, AM; Edwards, AP; Ely, L; Engelman, DM; Freeman-Cook, LL; Yates, KE1
Daikhin, E; DeBerardinis, RJ; Mancuso, A; Nissim, I; Thompson, CB; Wehrli, S; Yudkoff, M1
Deffie, AM; LéJohn, HB1
Kalckar, HM; Laursen, RA; Ullrey, DB1
Amos, H; Hochstadt, B; Sens, DA1
Burrows, H; Cohen, JS; Navon, G1
Dass, PD; Murdoch, FE; Wu, MC1
Aaronson, SA; Dunn, CY; Reddy, EP; Rhim, JS; Srivastava, SK; Yuasa, Y1
Dean, A; Erard, F; Schechter, AN1
Little, JB; Zimmerman, RJ1
Coleman, PS; Lavietes, BB1
Geyer, M; Kalbitzer, HR; Scheffzek, K; Schweins, T; Warshel, A; Wittinghofer, A1
Bode, BP; Fischer, CP; Souba, WW1
Eigenbrodt, E; Jansen-Dürr, P; Mazurek, S; Zwerschke, W1
Ajima, R; K-Tsuzuku, J; Nakamura, T; Suzuki, T; Yamamoto, T; Yoshida, Y1
Rifas, L; Seifter, S; Takahashi, S1
Gammon, MT; Isselbacher, KJ1
Christopher, CW; Kalckar, HM; Ullrey, D1
Baker, ME1
Buku, A; Carty, DJ; Chen, J; De Vivo, M; Iyengar, R; Kroll, SD; Premont, RT1
Chu, CL; Leonard, M; Olmedo, R; Scher, BM; Scher, GS; Scher, W; Stecker, S; Waxman, S; Wu, H1
DiMaio, D; Horwitz, BH; Kulke, R; Zibello, T1
Bourne, HR; Masters, SB; Zachary, I1
Rubin, AL1
Bizub, D; Felix, A; Fischberg-Bender, E; Heimer, EP; Skalka, AM1
Avitable, M; Brandt-Rauf, PW; Carty, RP; Gibson, KD; Lubowsky, J; Pincus, MR; Scheraga, HA1
Foster, DO; Pardee, AB1
Chandrabose, KA; Critchley, DR; Humphrey, D; MacPherson, I1
van Os, FH1
Tsuiki, S1

Reviews

20 review(s) available for glutamine and Cell Transformation, Neoplastic

ArticleYear
Targeting fuel pocket of cancer cell metabolism: A focus on glutaminolysis.
    Biochemical pharmacology, 2022, Volume: 198

    Topics: Cell Transformation, Neoplastic; Citric Acid Cycle; Glutamine; Humans; Metabolic Networks and Pathways; Neoplasms; Tumor Microenvironment

2022
Metabolic reprogramming of glutamine involved in tumorigenesis, multidrug resistance and tumor immunity.
    European journal of pharmacology, 2023, Feb-05, Volume: 940

    Topics: Amino Acids; Cell Transformation, Neoplastic; Drug Resistance, Multiple; Glutamine; Humans; Neoplasms

2023
A Shifty Target: Tumor-Initiating Cells and Their Metabolism.
    International journal of molecular sciences, 2019, Oct-28, Volume: 20, Issue:21

    Topics: Biomarkers, Tumor; Cell Transformation, Neoplastic; Fatty Acids; Glutamine; Induced Pluripotent Stem Cells; Mitochondria; Mitochondrial Dynamics; Neoplastic Stem Cells; Organelle Biogenesis; Oxidative Phosphorylation; Tumor Microenvironment

2019
Glutamine reliance in cell metabolism.
    Experimental & molecular medicine, 2020, Volume: 52, Issue:9

    Topics: Animals; Cell Transformation, Neoplastic; Disease Susceptibility; Energy Metabolism; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Glutamine; Humans; Metabolic Networks and Pathways; Metabolome; Metabolomics; Neoplasms; Oxidation-Reduction; Signal Transduction

2020
Therapeutic strategies impacting cancer cell glutamine metabolism.
    Future medicinal chemistry, 2013, Volume: 5, Issue:14

    Topics: Animals; Antineoplastic Agents; Cell Transformation, Neoplastic; Glutaminase; Glutamine; Humans; Models, Molecular; Molecular Targeted Therapy; Neoplasms; Signal Transduction

2013
Glutamate as chemotactic fuel for diffuse glioma cells: are they glutamate suckers?
    Biochimica et biophysica acta, 2014, Volume: 1846, Issue:1

    Topics: Animals; Brain Neoplasms; Cell Transformation, Neoplastic; Chemotaxis; Enzyme Inhibitors; Glioma; Glutamic Acid; Glutamine; Humans; Isocitrate Dehydrogenase

2014
Glutaminolysis and autophagy in cancer.
    Autophagy, 2015, Volume: 11, Issue:8

    Topics: Animals; Autophagy; Cell Proliferation; Cell Transformation, Neoplastic; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Glutamine; Humans; Ketoglutaric Acids; Mechanistic Target of Rapamycin Complex 1; Multiprotein Complexes; Neoplasm Recurrence, Local; Neoplasms; Reactive Oxygen Species; Signal Transduction; TOR Serine-Threonine Kinases

2015
The role of mammalian sirtuins in cancer metabolism.
    Seminars in cell & developmental biology, 2015, Volume: 43

    Topics: Aging; Animals; Cell Proliferation; Cell Transformation, Neoplastic; Glutamine; Glycolysis; Humans; Mice; Mitochondria; Neoplasms; Signal Transduction; Sirtuins

2015
The greedy nature of mutant RAS: a boon for drug discovery targeting cancer metabolism?
    Acta biochimica et biophysica Sinica, 2016, Volume: 48, Issue:1

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Drug Discovery; Gene Expression Regulation, Neoplastic; Genes, ras; Glutamine; Glycolysis; Humans; Mice; Molecular Targeted Therapy; Mutation; Neoplasm Transplantation; Neoplasms; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; ras Proteins; RNA Interference; Signal Transduction

2016
Metabolic reprogramming in cancer cells: glycolysis, glutaminolysis, and Bcl-2 proteins as novel therapeutic targets for cancer.
    World journal of surgical oncology, 2016, Jan-20, Volume: 14, Issue:1

    Topics: Antineoplastic Agents; Apoptosis; Biomarkers, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Glutamine; Glycolysis; Humans; Mitochondria; Proto-Oncogene Proteins c-bcl-2

2016
Glutaminolysis: A Hallmark of Cancer Metabolism.
    Annual review of biomedical engineering, 2017, 06-21, Volume: 19

    Topics: Animals; Biomarkers, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Glutamine; Humans; Mitochondria; Models, Biological; Neoplasms; Signal Transduction

2017
The molecular determinants of de novo nucleotide biosynthesis in cancer cells.
    Current opinion in genetics & development, 2009, Volume: 19, Issue:1

    Topics: Animals; Cell Line, Tumor; Cell Transformation, Neoplastic; Glucose; Glutamine; Glycolysis; Humans; Models, Biological; Neoplasms; Pentose Phosphate Pathway; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-myc; Ribosemonophosphates

2009
MYC-induced cancer cell energy metabolism and therapeutic opportunities.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2009, Nov-01, Volume: 15, Issue:21

    Topics: Cell Transformation, Neoplastic; Energy Metabolism; Gene Expression Regulation, Neoplastic; Genes, myc; Glucose; Glutamine; Glycolysis; Humans; Hypoxia-Inducible Factor 1; Neoplasms; Oxidative Phosphorylation; Proto-Oncogene Proteins c-myc; Signal Transduction

2009
Pyruvate kinase type M2: a key regulator of the metabolic budget system in tumor cells.
    The international journal of biochemistry & cell biology, 2011, Volume: 43, Issue:7

    Topics: Animals; Biomarkers, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Glucose; Glutamine; Glycolysis; Humans; Isoenzymes; Metabolic Networks and Pathways; Mice; Models, Biological; Neoplasm Proteins; Neoplasms; Octamer Transcription Factor-3; Oncogene Proteins; Protein Interaction Mapping; Protein Serine-Threonine Kinases; Pyruvate Kinase; Rats; Tumor Suppressor Proteins

2011
Balancing biosynthesis and bioenergetics: metabolic programs in oncogenesis.
    Endocrine-related cancer, 2010, Volume: 17, Issue:4

    Topics: Cell Transformation, Neoplastic; Energy Metabolism; Fatty Acids; Glutamine; Glycolysis; Humans; Neoplasms; Signal Transduction

2010
Metabolism and brain cancer.
    Clinics (Sao Paulo, Brazil), 2011, Volume: 66 Suppl 1

    Topics: Brain Neoplasms; Cell Proliferation; Cell Transformation, Neoplastic; Citric Acid Cycle; Glutaminase; Glutamine; Glycolysis; Humans; Oncogenes; Pentose Phosphate Pathway; Stem Cells

2011
Alterations of metabolic genes and metabolites in cancer.
    Seminars in cell & developmental biology, 2012, Volume: 23, Issue:4

    Topics: Animals; Cell Transformation, Neoplastic; Energy Metabolism; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Genes, Neoplasm; Glucose; Glutamine; Humans; Metabolic Networks and Pathways; Metabolome; Mutation; Neoplasms

2012
Metabolic reprogramming in cancer: unraveling the role of glutamine in tumorigenesis.
    Seminars in cell & developmental biology, 2012, Volume: 23, Issue:4

    Topics: Animals; Cell Proliferation; Cell Transformation, Neoplastic; Energy Metabolism; Glucose; Glutamine; Humans; Mutation; Neoplasms; Oxidation-Reduction; Proto-Oncogene Proteins; Signal Transduction

2012
[Plants with cytostatic effect].
    Il Farmaco; edizione scientifica, 1970, Volume: 25, Issue:6

    Topics: Alkaloids; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Cell Nucleus; Cell Transformation, Neoplastic; Colchicine; Colchicum; DNA; Drug Synergism; Glutamine; Glycolysis; Humans; Leukemia; Mercaptopurine; Methotrexate; Mitosis; Neoplasms; Plant Extracts; Plants, Medicinal; Plants, Toxic; Podophyllum; Prednisone; Purines; Pyrimidines; RNA; Steroids; Vincristine

1970
[Differentiation anomaly of tumor cells and enzymes].
    Naika. Internal medicine, 1971, Volume: 28, Issue:4

    Topics: Animals; Cell Differentiation; Cell Transformation, Neoplastic; Fetus; Glucokinase; Glucosamine; Glutamine; Hexokinase; Isoenzymes; Isomerases; Liver; Mice; Neoplasms; Neoplasms, Experimental; Rats; Transaminases

1971

Trials

1 trial(s) available for glutamine and Cell Transformation, Neoplastic

ArticleYear
In Vivo PET Assay of Tumor Glutamine Flux and Metabolism: In-Human Trial of
    Radiology, 2018, Volume: 287, Issue:2

    Topics: Adult; Aged; Biomarkers, Tumor; Cell Transformation, Neoplastic; Female; Fluorine Radioisotopes; Glutamine; Humans; Male; Middle Aged; Neoplasms; Positron-Emission Tomography; Tissue Distribution; United States; United States Food and Drug Administration

2018

Other Studies

63 other study(ies) available for glutamine and Cell Transformation, Neoplastic

ArticleYear
Circ_0067717 promotes colorectal cancer cell growth, invasion and glutamine metabolism by serving as a miR-497-5p sponge to upregulate SLC7A5.
    Histology and histopathology, 2023, Volume: 38, Issue:1

    Topics: Animals; Cell Proliferation; Cell Transformation, Neoplastic; Colorectal Neoplasms; Disease Models, Animal; Glutamine; Humans; Large Neutral Amino Acid-Transporter 1; MicroRNAs

2023
Cryptotanshinone suppresses tumorigenesis by inhibiting lipogenesis and promoting reactive oxygen species production in KRAS‑activated pancreatic cancer cells.
    International journal of oncology, 2022, Volume: 61, Issue:3

    Topics: Carcinogenesis; Cell Line, Tumor; Cell Transformation, Neoplastic; Colorectal Neoplasms; Glutamine; Humans; Lipids; Lipogenesis; Pancreatic Neoplasms; Phenanthrenes; Proto-Oncogene Proteins p21(ras); Reactive Oxygen Species; Signal Transduction

2022
Pancreatic stellate cells exploit Wnt/β-catenin/TCF7-mediated glutamine metabolism to promote pancreatic cancer cells growth.
    Cancer letters, 2023, Feb-28, Volume: 555

    Topics: beta Catenin; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Glutamine; Humans; Pancreatic Neoplasms; Pancreatic Stellate Cells; T Cell Transcription Factor 1

2023
Environmental cadmium exposure facilitates mammary tumorigenesis via reprogramming gut microbiota-mediated glutamine metabolism in MMTV-Erbb2 mice.
    The Science of the total environment, 2023, Nov-01, Volume: 897

    Topics: Animals; Cadmium; Carcinogenesis; Cell Transformation, Neoplastic; Gastrointestinal Microbiome; Glutamine; Ki-67 Antigen; Mammary Neoplasms, Experimental; Mice; Mice, Transgenic; Necrosis

2023
miR-122-5p Restrains Pancreatic Cancer Cell Growth and Causes Apoptosis by Negatively Regulating ASCT2.
    Anticancer research, 2023, Volume: 43, Issue:10

    Topics: Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic; Gene Expression Regulation, Neoplastic; Glutamine; Humans; Ketoglutaric Acids; MicroRNAs; Pancreatic Neoplasms

2023
Cronkhite-Canada syndrome associated with perianal condyloma acuminatum with malignant transformation: A case report.
    Medicine, 2021, Mar-12, Volume: 100, Issue:10

    Topics: Anal Canal; Anus Neoplasms; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Condylomata Acuminata; Endoscopy, Gastrointestinal; Glucocorticoids; Glutamine; Humans; Intestinal Polyposis; Male; Middle Aged; Nutritional Support; Treatment Outcome

2021
Asparagine sustains cellular proliferation and c‑Myc expression in glutamine‑starved cancer cells.
    Oncology reports, 2021, Volume: 45, Issue:6

    Topics: Asparagine; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Cysteine Proteinase Inhibitors; Gene Expression Regulation, Neoplastic; Glutamate-Ammonia Ligase; Glutamine; Humans; Leupeptins; Methionine Sulfoximine; Proteasome Endopeptidase Complex; Protein Isoforms; Proteolysis; Proto-Oncogene Proteins c-myc

2021
Deprivation of glutamine in cell culture reveals its potential for treating cancer.
    Proceedings of the National Academy of Sciences of the United States of America, 2019, 04-02, Volume: 116, Issue:14

    Topics: Animals; BALB 3T3 Cells; Cell Culture Techniques; Cell Transformation, Neoplastic; Culture Media; Glutamine; Mice; Neoplasms

2019
Cellular response to glutamine and/or glucose deprivation in in vitro transformed human fibroblasts.
    Oncology reports, 2019, Volume: 41, Issue:6

    Topics: Apoptosis; Autophagy; Caspases; Cell Cycle Checkpoints; Cell Death; Cell Proliferation; Cell Transformation, Neoplastic; DNA Breaks, Double-Stranded; Fibroblasts; Glucose; Glutamine; Humans; Molecular Targeted Therapy; Poly (ADP-Ribose) Polymerase-1; Starvation

2019
Chemopreventive effect of dietary glutamine on colitis-associated colon tumorigenesis in mice.
    Carcinogenesis, 2013, Volume: 34, Issue:7

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Azoxymethane; Biomarkers, Tumor; Blotting, Western; Cell Proliferation; Cell Transformation, Neoplastic; Chemoprevention; Colitis; Colon; Colorectal Neoplasms; Cyclooxygenase 2; Dextran Sulfate; Dietary Supplements; Enzyme-Linked Immunosorbent Assay; Female; Glutamine; Immunohistochemistry; Male; Mice; Mice, Inbred BALB C; NF-kappa B; Nitric Oxide Synthase Type II; Real-Time Polymerase Chain Reaction; Rectum; Severity of Illness Index

2013
Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells.
    Nature, 2013, May-30, Volume: 497, Issue:7451

    Topics: Amino Acids; Animals; Biological Transport; Carbon; Cell Line, Transformed; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Disease Models, Animal; Female; Glutamine; Mice; Mice, Nude; NIH 3T3 Cells; Oncogene Protein p21(ras); Pancreatic Neoplasms; Pinocytosis; Proteolysis

2013
No association between the XPD Lys751Gln (rs13181) polymorphism and disease phenotype or leukemic transformation in primary myelofibrosis.
    Haematologica, 2013, Volume: 98, Issue:8

    Topics: Cell Transformation, Neoplastic; Cohort Studies; Genetic Variation; Glutamine; Humans; Leukemia, Myeloid, Acute; Lysine; Phenotype; Polymorphism, Genetic; Primary Myelofibrosis; Xeroderma Pigmentosum Group D Protein

2013
Cancer metabolism in breadth and depth.
    Nature biotechnology, 2013, Volume: 31, Issue:6

    Topics: Animals; Benzeneacetamides; Cell Differentiation; Cell Transformation, Neoplastic; Enzyme Inhibitors; Glioma; Glutamine; Hematopoiesis; Humans; Imidazoles; Isocitrate Dehydrogenase; Leukemia, Myeloid, Acute; Metabolic Networks and Pathways; Neoplasms; Oncogene Protein p21(ras); Pancreatic Neoplasms; Phenylurea Compounds; Proto-Oncogene Proteins; ras Proteins; Sulfonamides

2013
MYC, metabolism, cell growth, and tumorigenesis.
    Cold Spring Harbor perspectives in medicine, 2013, Aug-01, Volume: 3, Issue:8

    Topics: Carcinogenesis; Cell Transformation, Neoplastic; Gene Expression Regulation, Neoplastic; Genes, myc; Genes, p53; Glucose; Glutamine; Humans; Lipid Metabolism; Mitochondria; Neoplasms; Proto-Oncogene Mas; Proto-Oncogene Proteins c-myc; Ribosomes; Signal Transduction; Transcription Factors

2013
Autophagy sustains mitochondrial glutamine metabolism and growth of BrafV600E-driven lung tumors.
    Cancer discovery, 2013, Volume: 3, Issue:11

    Topics: Adenocarcinoma; Adenoma; Adenoma, Oxyphilic; Animals; Autophagy; Autophagy-Related Protein 7; Cell Line, Tumor; Cell Transformation, Neoplastic; Disease Models, Animal; Gene Deletion; Gene Expression Regulation, Neoplastic; Glutamine; Humans; Lung Neoplasms; Mice; Microtubule-Associated Proteins; Mitochondria; NF-E2-Related Factor 2; Oxidative Stress; Proto-Oncogene Proteins B-raf; Tumor Suppressor Protein p53

2013
Mechanism by which a recently discovered allosteric inhibitor blocks glutamine metabolism in transformed cells.
    Proceedings of the National Academy of Sciences of the United States of America, 2015, Jan-13, Volume: 112, Issue:2

    Topics: Allosteric Regulation; Amino Acid Substitution; Animals; Benzophenanthridines; Cell Transformation, Neoplastic; Enzyme Inhibitors; Fluorescence Resonance Energy Transfer; Glutamine; Mice; Models, Molecular; Mutagenesis, Site-Directed; Protein Structure, Quaternary; Recombinant Proteins; Transaminases

2015
Fumarate induces redox-dependent senescence by modifying glutathione metabolism.
    Nature communications, 2015, Jan-23, Volume: 6

    Topics: Animals; Cell Line; Cell Proliferation; Cell Transformation, Neoplastic; Cellular Senescence; Chromatography, Liquid; Computational Biology; Female; Fibroblasts; Fumarate Hydratase; Fumarates; Glutamine; Glutathione; Immunohistochemistry; Kidney; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Metabolomics; Mice; Mice, Inbred C57BL; Mutation; Oxidation-Reduction; Oxidative Stress; Transcriptome

2015
Glutamine promotes ovarian cancer cell proliferation through the mTOR/S6 pathway.
    Endocrine-related cancer, 2015, Volume: 22, Issue:4

    Topics: Adenosine Triphosphate; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Female; Glucose; Glutamine; Humans; Lactic Acid; Mitogen-Activated Protein Kinases; Ovarian Neoplasms; Reactive Oxygen Species; Ribosomal Protein S6 Kinases; TOR Serine-Threonine Kinases

2015
ATM in senescence.
    Oncotarget, 2015, Jun-20, Volume: 6, Issue:17

    Topics: Ataxia Telangiectasia Mutated Proteins; Cell Transformation, Neoplastic; Cellular Reprogramming; Cellular Senescence; DNA Damage; DNA Replication; Gene Knockdown Techniques; Glucose; Glucosephosphate Dehydrogenase; Glutamine; Humans; Models, Biological; Mutation; Nucleotides; Proto-Oncogene Proteins c-myc; Stress, Physiological; Tumor Suppressor Protein p53

2015
The oncogenic transcription factor c-Jun regulates glutaminase expression and sensitizes cells to glutaminase-targeted therapy.
    Nature communications, 2016, Apr-18, Volume: 7

    Topics: Animals; Base Sequence; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; Embryo, Mammalian; Fibroblasts; Gene Expression Regulation, Neoplastic; Glutaminase; Glutamine; Humans; MCF-7 Cells; Mice; Molecular Sequence Data; Neoplasms; Promoter Regions, Genetic; Protein Binding; Proto-Oncogene Mas; Proto-Oncogene Proteins c-jun; Reverse Transcriptase Polymerase Chain Reaction; rho GTP-Binding Proteins; RNA Interference

2016
Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self-renewal and malignancy.
    Nature immunology, 2016, Volume: 17, Issue:6

    Topics: Animals; Cell Proliferation; Cell Self Renewal; Cell Transformation, Neoplastic; Clone Cells; Female; Glucose; Glutamine; Lymphocyte Activation; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Male; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Acetylglucosaminyltransferases; Proto-Oncogene Proteins c-myc; Receptors, Antigen, T-Cell; Receptors, Notch; T-Lymphocytes; Uridine Diphosphate N-Acetylglucosamine

2016
Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth.
    Nature cell biology, 2016, Volume: 18, Issue:8

    Topics: Adaptor Proteins, Signal Transducing; Animals; Animals, Genetically Modified; Carcinoma, Hepatocellular; Cell Proliferation; Cell Transformation, Neoplastic; Glutamine; Humans; Liver; Liver Neoplasms; Phosphoproteins; Trans-Activators; Transcription Factors; YAP-Signaling Proteins; Zebrafish; Zebrafish Proteins

2016
Circadian Rhythm Disruption Promotes Lung Tumorigenesis.
    Cell metabolism, 2016, 08-09, Volume: 24, Issue:2

    Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Carcinogenesis; Cell Proliferation; Cell Transformation, Neoplastic; Cellular Reprogramming; Circadian Rhythm; Glucose; Glutamine; Humans; Jet Lag Syndrome; Lung; Lung Neoplasms; Mice, Inbred C57BL; Mutation; Period Circadian Proteins; Proto-Oncogene Proteins c-myc

2016
Finding an "Achilles' heel" of cancer: the role of glucose and glutamine metabolism in the survival of transformed cells.
    Cell cycle (Georgetown, Tex.), 2008, Jul-15, Volume: 7, Issue:14

    Topics: Animals; Cell Survival; Cell Transformation, Neoplastic; Glucose; Glutamine; Humans; Mice; Neoplasms

2008
Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells.
    Science (New York, N.Y.), 2008, Oct-31, Volume: 322, Issue:5902

    Topics: Aneuploidy; Animals; Cell Cycle; Cell Line; Cell Proliferation; Cell Size; Cell Transformation, Neoplastic; Cellular Senescence; Culture Media; Embryo, Mammalian; Fibroblasts; Gene Dosage; Gene Expression; Genomic Instability; Glucose; Glutamine; Metabolic Networks and Pathways; Mice; Serial Passage; Translocation, Genetic; Trisomy

2008
Glutamine deprivation induces abortive s-phase rescued by deoxyribonucleotides in k-ras transformed fibroblasts.
    PloS one, 2009, Volume: 4, Issue:3

    Topics: 3T3 Cells; Animals; Cell Cycle; Cell Proliferation; Cell Transformation, Neoplastic; Deoxyribonucleotides; Fibroblasts; Genes, ras; Glutamine; Mice; S Phase

2009
Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity.
    Proceedings of the National Academy of Sciences of the United States of America, 2010, May-11, Volume: 107, Issue:19

    Topics: Aerobiosis; Animals; Cell Adhesion; Cell Proliferation; Cell Transformation, Neoplastic; Electron Transport Complex III; Extracellular Signal-Regulated MAP Kinases; Glutamine; Glycolysis; HCT116 Cells; Humans; Lung Neoplasms; Mice; Mitochondria; Oxidative Phosphorylation; Pentose Phosphate Pathway; Proto-Oncogene Proteins p21(ras); Reactive Oxygen Species

2010
Oxidative phosphorylation induces de novo expression of the MHC class I in tumor cells through the ERK5 pathway.
    Journal of immunology (Baltimore, Md. : 1950), 2010, Sep-15, Volume: 185, Issue:6

    Topics: Adenosine Triphosphate; Animals; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Down-Regulation; Gene Expression Regulation; Glutamine; Histocompatibility Antigens Class I; Humans; Jurkat Cells; Leukemia L1210; Leukemia, B-Cell; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 7; Oxidative Phosphorylation; Up-Regulation

2010
Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth.
    Molecular systems biology, 2011, Aug-16, Volume: 7

    Topics: Animals; Cell Line, Transformed; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Citric Acid Cycle; Fibroblasts; Flow Cytometry; Gas Chromatography-Mass Spectrometry; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glucose; Glutamine; Glycolysis; Humans; Isotope Labeling; Mice; Neoplasms; NIH 3T3 Cells; Oligonucleotide Array Sequence Analysis; Proto-Oncogene Proteins p21(ras)

2011
PET imaging of glutaminolysis in tumors by 18F-(2S,4R)4-fluoroglutamine.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2011, Volume: 52, Issue:12

    Topics: Animals; Biological Transport; Breast Neoplasms; Cell Line, Tumor; Cell Transformation, Neoplastic; Female; Glioblastoma; Glutamine; Humans; Male; Mice; Mice, Transgenic; Positron-Emission Tomography; Rats

2011
Preparation and characterization of L-[5-11C]-glutamine for metabolic imaging of tumors.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2012, Volume: 53, Issue:1

    Topics: Animals; Astrocytoma; Biological Transport; Carbon Radioisotopes; Cell Line, Tumor; Cell Transformation, Neoplastic; Cyanides; Glioma; Glutamine; Humans; Hydrolysis; Male; Mice; Mice, Transgenic; Positron-Emission Tomography; Radiochemistry; Rats

2012
The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type.
    Cell metabolism, 2012, Feb-08, Volume: 15, Issue:2

    Topics: Animals; Blotting, Western; Cell Line, Tumor; Cell Transformation, Neoplastic; Citric Acid Cycle; DNA Primers; Glucokinase; Glucose; Glutamine; Humans; Immunoblotting; Immunohistochemistry; Isotope Labeling; Lactic Acid; Liver Neoplasms, Experimental; Lung Neoplasms; Metabolome; Mice; Nuclear Magnetic Resonance, Biomolecular; Proto-Oncogene Proteins c-met; Proto-Oncogene Proteins c-myc; RNA Interference

2012
Deregulated MYC expression induces dependence upon AMPK-related kinase 5.
    Nature, 2012, Mar-28, Volume: 483, Issue:7391

    Topics: Adenosine Triphosphate; AMP-Activated Protein Kinases; Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Respiration; Cell Survival; Cell Transformation, Neoplastic; Disease Models, Animal; Doxycycline; Electron Transport; Gene Expression Regulation, Neoplastic; Genes, myc; Glutamine; Homeostasis; Humans; Liver Neoplasms; Mechanistic Target of Rapamycin Complex 1; Mice; Mitochondria; Multiprotein Complexes; Oncogene Protein p55(v-myc); Protein Biosynthesis; Protein Kinases; Proteins; Repressor Proteins; RNA Interference; Signal Transduction; TOR Serine-Threonine Kinases

2012
Comparative evaluation of 18F-labeled glutamic acid and glutamine as tumor metabolic imaging agents.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2012, Volume: 53, Issue:10

    Topics: Animals; Biological Transport; Cell Line, Tumor; Cell Transformation, Neoplastic; Fluorine Radioisotopes; Glutamic Acid; Glutamine; Humans; Male; Molecular Imaging; Radiochemistry; Rats; Stereoisomerism

2012
c-Myc and cancer metabolism.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2012, Oct-15, Volume: 18, Issue:20

    Topics: Cell Proliferation; Cell Transformation, Neoplastic; Gene Expression Regulation, Neoplastic; Glutamine; Glycolysis; Humans; Mitochondria; Molecular Targeted Therapy; Neoplasms; Proto-Oncogene Proteins c-myc

2012
Specific locations of hydrophilic amino acids in constructed transmembrane ligands of the platelet-derived growth factor beta receptor.
    Journal of molecular biology, 2005, Jan-28, Volume: 345, Issue:4

    Topics: Amino Acid Sequence; Amino Acids; Animals; Binding Sites; Cell Transformation, Neoplastic; Dimerization; Enzyme Inhibitors; Gene Library; Glutamine; Humans; Hydrophobic and Hydrophilic Interactions; Ligands; Mice; Models, Molecular; Molecular Sequence Data; Mutation; Protein Structure, Quaternary; Proteins; Receptor, Platelet-Derived Growth Factor beta; Sequence Alignment; Signal Transduction; Substrate Specificity; Tyrphostins

2005
Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis.
    Proceedings of the National Academy of Sciences of the United States of America, 2007, Dec-04, Volume: 104, Issue:49

    Topics: Aerobiosis; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Citric Acid Cycle; Glioblastoma; Glucose; Glutamine; Glycolysis; Humans; Nucleotides; Protein Biosynthesis

2007
Involvement of protease in L-glutamine control of nucleic acid and polyphosphate metabolism in cells transformed by 9,10-dimethyl-1,2-benzanthracene, SV40 and H-ras oncogene.
    Biochemical and biophysical research communications, 1984, Oct-15, Volume: 124, Issue:1

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Cell Line; Cell Transformation, Neoplastic; DNA Replication; Glutamine; Humans; Kinetics; Lung; Oncogenes; Peptide Hydrolases; Polyphosphates; Protease Inhibitors; Simian virus 40; Temperature; Transcription, Genetic

1984
Effects of combined glutamine and serum deprivation on glucose control of hexose transport in mammalian fibroblast cultures.
    Proceedings of the National Academy of Sciences of the United States of America, 1980, Volume: 77, Issue:10

    Topics: Animals; Biological Transport; Blood; Cell Transformation, Neoplastic; Cells, Cultured; Cricetinae; Culture Media; Fibroblasts; Galactose; Glucose; Glutamine; Hexoses; Polyomavirus

1980
Effects of pyruvate on the growth of normal and transformed hamster embryo fibroblasts.
    Journal of cellular physiology, 1982, Volume: 110, Issue:3

    Topics: Animals; Cell Division; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cricetinae; Dose-Response Relationship, Drug; Embryo, Mammalian; Fibroblasts; Glucose; Glutamine; Lactates; Lactic Acid; Polyomavirus; Pyruvates; Pyruvic Acid

1982
Differences in metabolite levels upon differentiation of intact neuroblastoma X glioma cells observed by proton NMR spectroscopy.
    FEBS letters, 1983, Oct-17, Volume: 162, Issue:2

    Topics: Animals; Cell Transformation, Neoplastic; Glioma; Glutamine; Hybrid Cells; Magnetic Resonance Spectroscopy; Mice; Neuroblastoma; Peptides; Prostaglandins E; Protein Sorting Signals; Protons; Rats; Theophylline

1983
Glutamine promotes colony formation in bone marrow and HL-60 cells; accelerates myeloid differentiation in induced HL-60 cells.
    In vitro, 1984, Volume: 20, Issue:11

    Topics: Animals; Bone Marrow; Bone Marrow Cells; Cell Transformation, Neoplastic; Cells, Cultured; Dimethyl Sulfoxide; Glutamine; Humans; Leukemia, Myeloid; Mice; Stem Cells

1984
Acquisition of transforming properties by alternative point mutations within c-bas/has human proto-oncogene.
    Nature, 1983, Jun-30, Volume: 303, Issue:5920

    Topics: Base Sequence; Cell Line; Cell Transformation, Neoplastic; Cloning, Molecular; Glutamine; Humans; Leucine; Lung Neoplasms; Mutation; Oncogenes; Proto-Oncogene Mas; Urinary Bladder Neoplasms

1983
Inhibitors of cell division reversibly modify hemoglobin concentration in human erythroleukemia K562 cells.
    Blood, 1981, Volume: 58, Issue:6

    Topics: Cell Transformation, Neoplastic; Culture Media; Glutamine; Hemin; Hemoglobins; Humans; Hydroxyurea; Isoelectric Focusing; Leukemia, Erythroblastic, Acute; Time Factors

1981
Starvation for arginine and glutamine sensitizes human diploid cells to the transforming effects of N-acetoxy-2-acetylaminofluorene.
    Carcinogenesis, 1981, Volume: 2, Issue:12

    Topics: 2-Acetylaminofluorene; Acetoxyacetylaminofluorene; Arginine; Cell Transformation, Neoplastic; Cells, Cultured; DNA Repair; DNA Replication; Fibroblasts; Glutamine; Humans; Kinetics; Male; Skin; Skin Physiological Phenomena

1981
The role of lipid metabolism in neoplastic differentiation.
    Journal of theoretical biology, 1980, Aug-07, Volume: 85, Issue:3

    Topics: Animals; Asparagine; Cell Transformation, Neoplastic; Cholesterol; Citric Acid Cycle; Feedback; Glucose; Glutamine; Humans; Lipids; Models, Biological; Neoplasms, Experimental; Nitrogen; Oxygen Consumption; Polyamines

1980
Substrate-assisted catalysis as a mechanism for GTP hydrolysis of p21ras and other GTP-binding proteins.
    Nature structural biology, 1995, Volume: 2, Issue:1

    Topics: Amino Acid Sequence; Animals; Binding Sites; Catalysis; Cell Transformation, Neoplastic; Computer Simulation; Crystallography, X-Ray; Glutamine; GTP-Binding Proteins; GTPase-Activating Proteins; Guanosine Triphosphate; Hydrolysis; Insecta; Kinetics; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Binding; Protein Conformation; Proteins; Proto-Oncogene Proteins p21(ras); ras GTPase-Activating Proteins; Recombinant Fusion Proteins; Structure-Activity Relationship; Thermodynamics; Water

1995
Adaptive alterations in cellular metabolism with malignant transformation.
    Annals of surgery, 1998, Volume: 227, Issue:5

    Topics: Adaptation, Physiological; Animals; Cell Transformation, Neoplastic; Fibroblasts; Fibrosarcoma; Glucose; Glutamine; Kidney; Rats; Rats, Inbred F344; Tumor Cells, Cultured

1998
Metabolic cooperation between different oncogenes during cell transformation: interaction between activated ras and HPV-16 E7.
    Oncogene, 2001, Oct-18, Volume: 20, Issue:47

    Topics: Adenylate Kinase; Animals; Aspartate Aminotransferases; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Glutamine; Glycolysis; Kidney; Models, Biological; Neoplasms; Nucleotides; Oncogene Protein p21(ras); Oncogene Proteins, Viral; Papillomavirus E7 Proteins; Pyruvate Kinase; Rats; Serine; Transfection

2001
Phosphorylation of three regulatory serines of Tob by Erk1 and Erk2 is required for Ras-mediated cell proliferation and transformation.
    Genes & development, 2002, Jun-01, Volume: 16, Issue:11

    Topics: 3T3 Cells; Alanine; Animals; Carrier Proteins; Cell Cycle; Cell Division; Cell Transformation, Neoplastic; Cyclin D1; Enzyme Inhibitors; Flavonoids; G1 Phase; Glutamic Acid; Glutamine; Glutathione Transferase; Intracellular Signaling Peptides and Proteins; Mice; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Peptide Mapping; Phosphorylation; Phosphoserine; Plasmids; Protein Structure, Tertiary; ras Proteins; Resting Phase, Cell Cycle; S Phase; Serine; Time Factors; Transfection

2002
gamma-Glutamyltransferase in human diploid fibroblasts and other mammalian cells.
    In vitro, 1978, Volume: 14, Issue:3

    Topics: Animals; Cell Line; Cell Membrane; Cell Transformation, Neoplastic; Diploidy; Fibroblasts; gamma-Glutamyltransferase; Glutamine; Humans; Iodoacetamide; Mammals; Substrate Specificity

1978
Neoplastic potentials and regulation of uptake of nutrients. I. A glutamine independent variant of polyoma BHK with A very high neoplastic potential.
    Journal of cellular physiology, 1976, Volume: 89, Issue:4

    Topics: Agglutination; Animals; Cell Adhesion; Cell Division; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Concanavalin A; Cricetinae; Galactosyltransferases; Genetic Variation; Glutamine; Lactates; Neoplasms, Experimental; Polyomavirus

1976
Neoplastic potentials and regulation of uptake and nutrients. II. Inverse regulation of uptake of hexose and amino acid analogues in the neoplastic GIV line.
    Journal of cellular physiology, 1976, Volume: 89, Issue:4

    Topics: Amino Acids; Animals; Biological Transport, Active; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Cricetinae; Cycloleucine; Deoxyglucose; Galactose; Genetic Variation; Glucose; Glutamine; Hexoses; Polyomavirus; Stereoisomerism

1976
Stimulation of DNA synthesis by serum and amino acid in a rat neuroblastoma cell line.
    Experimental cell research, 1975, Oct-01, Volume: 95, Issue:1

    Topics: Amino Acids; Blood; Cell Division; Cell Line; Cell Transformation, Neoplastic; Culture Media; Cystine; DNA; Glutamine; Tyrosine

1975
The Q205LGo-alpha subunit expressed in NIH-3T3 cells induces transformation.
    The Journal of biological chemistry, 1992, Nov-15, Volume: 267, Issue:32

    Topics: 3T3 Cells; Amino Acid Sequence; Animals; Base Sequence; Cell Division; Cell Line; Cell Transformation, Neoplastic; Cloning, Molecular; Dexamethasone; Glutamine; GTP-Binding Proteins; Kinetics; Leucine; Macromolecular Substances; Mice; Mice, Nude; Molecular Sequence Data; Mutagenesis, Site-Directed; Myocardium; Neoplasm Transplantation; Oligodeoxyribonucleotides; Rats; Transfection; Type C Phospholipases

1992
Reduction in lactate accumulation correlates with differentiation-induced terminal cell division of leukemia cells.
    Differentiation; research in biological diversity, 1991, Volume: 48, Issue:1

    Topics: Acetamides; Animals; Carbon Dioxide; Cell Differentiation; Cell Division; Cell Transformation, Neoplastic; Dexamethasone; Dimethyl Sulfoxide; Glutamates; Glutamic Acid; Glutamine; Glycolysis; Humans; Lactates; Lactic Acid; Leukemia, Erythroblastic, Acute; Leukemia, Myeloid; Mice

1991
The central hydrophobic domain of the bovine papillomavirus E5 transforming protein can be functionally replaced by many hydrophobic amino acid sequences containing a glutamine.
    Journal of virology, 1992, Volume: 66, Issue:1

    Topics: Amino Acid Sequence; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; DNA; Glutamine; Molecular Sequence Data; Oncogene Proteins, Viral; Precipitin Tests

1992
Increased mitogenic responsiveness of Swiss 3T3 cells expressing constitutively active Gs alpha.
    Biochemical and biophysical research communications, 1990, May-16, Volume: 168, Issue:3

    Topics: Adenylyl Cyclases; Amino Acid Sequence; Animals; Cell Line; Cell Membrane; Cell Transformation, Neoplastic; Cyclic AMP; Enzyme Activation; Glutamine; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Hydrolysis; Immunoblotting; Leucine; Mitogens; Molecular Sequence Data; Mutation; Thionucleotides; Transfection

1990
Suppression of transformation by and growth adaptation to low concentrations of glutamine in NIH-3T3 cells.
    Cancer research, 1990, May-01, Volume: 50, Issue:9

    Topics: Adaptation, Physiological; Animals; Cell Transformation, Neoplastic; Cells, Cultured; Culture Media; Dose-Response Relationship, Drug; Glutamine; Mice

1990
Detection of transforming ras proteins containing leucine at position 61 by a new mouse monoclonal antibody, ras(53-69)Leu61.
    Cancer research, 1989, Nov-15, Volume: 49, Issue:22

    Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Cell Transformation, Neoplastic; Cells, Cultured; Female; Genes, ras; Genetic Vectors; Glutamine; Immunoblotting; Leucine; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Mutation; Oncogene Protein p21(ras)

1989
Conformational effects of substituting amino acids for glutamine-61 on the central transforming region of the P21 proteins.
    Proceedings of the National Academy of Sciences of the United States of America, 1987, Volume: 84, Issue:23

    Topics: Amino Acid Sequence; Cell Transformation, Neoplastic; Genes, ras; Glutamine; GTP-Binding Proteins; Models, Molecular; Protein Conformation; Structure-Activity Relationship; Thermodynamics

1987
Transport of amino acids by confluent and nonconfluent 3T3 and polyoma virus-transformed 3T3 cells growing on glass cover slips.
    The Journal of biological chemistry, 1969, May-25, Volume: 244, Issue:10

    Topics: Amino Acids; Aminoisobutyric Acids; Animals; Arginine; Biological Transport; Cell Line; Cell Transformation, Neoplastic; Contact Inhibition; Culture Techniques; Cytopathogenic Effect, Viral; Embryo, Mammalian; Glutamates; Glutamine; Mice; Polyomavirus

1969
Cell surface modifications in virus-transformed cells--glycolipid changes in the NIL2 hamster cells.
    Johns Hopkins medical journal. Supplement, 1973, Volume: 2

    Topics: Animals; Carbohydrates; Carbon Radioisotopes; Cell Count; Cell Line; Cell Membrane; Cell Transformation, Neoplastic; Cells, Cultured; Clone Cells; Cricetinae; Genetic Variation; Glutamine; Glycolipids; Oncogenic Viruses; Palmitic Acids; Polyomavirus; Sarcoma, Experimental; Thymidine; Transferases; Tritium

1973