glutamine and Benign Neoplasms

glutamine has been researched along with Benign Neoplasms in 485 studies

Research

Studies (485)

TimeframeStudies, this research(%)All Research%
pre-199042 (8.66)18.7374
1990's24 (4.95)18.2507
2000's48 (9.90)29.6817
2010's238 (49.07)24.3611
2020's133 (27.42)2.80

Authors

AuthorsStudies
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J1
Arellano, ML; Boggon, TJ; Brat, DJ; Chen, GZ; Chen, J; Chen, PR; DeBerardinis, RJ; Elf, S; Fan, J; Gu, TL; He, C; Hitosugi, T; Hurwitz, SJ; Ji, Q; Jiang, L; Kang, HB; Kang, S; Khoury, HJ; Khuri, FR; Lee, BH; Lei, Q; Li, Y; Lin, R; Lonial, S; Mao, H; Mitsche, M; Seo, JH; Shan, C; Sudderth, J; Tucker, M; Wang, D; Wu, S; Xie, J; Ye, K; Zhang, L; Zhang, S; Zhou, L1
Aguilar, JMH; Alt, J; Dash, RP; Gori, SS; Lemberg, KM; Majer, P; Pal, A; Rais, R; Slusher, BS; Sun, Q; Tenora, L; Veeravalli, V; Wu, Y1
Badolati, N; Crescenzi, E; Leonardi, A; Mellone, S; Pacifico, F; Stornaiuolo, M1
Du, J; Hu, W; Huang, Z; Li, Y; Tong, X; Wang, X; Wang, Y; Xia, J; Zhou, Y1
Chen, Z; DiGiovanni, J; Wilder, CS1
Brunner, JS; Finley, LWS1
Deng, M; Du, K; Guo, R; Li, S; Lin, W; Lu, L; Mei, J; Wei, W; Zou, J1
Cai, X; Cimino, FV; King, B; Pavlova, NN; Schwörer, S; Sizemore, GM; Thompson, CB1
Hu, J; Ji, L; Johnston, LJ; Liu, C; Ma, X; Zhang, X; Zhao, Y1
Kraft, R; Krumbholz, P; Liebing, AD; Rabe, P; Stäubert, C1
Cabañas-Alite, L; García-Gozalbo, B1
Arenholz, E; Cerione, RA; Finke, A; Huang, Q; Katt, WP; Kriksunov, I; McDermott, LA; Milano, SK; Nguyen, TT; Ramachandran, S; Schuller, DJ; Sukumar, N; Szebenyi, DM1
Ding, M; Dong, R; Fares, HM; Li, X; Lyu, X; Mi, S; Sun, L; Wang, Y; Xu, X; Yuan, S1
Guo, H; Honda, Y; Matsui, M; Miura, Y; Nishiyama, N; Nomoto, T; Takemoto, H; Taniwaki, K1
Li, N; Lu, F; Pan, W; Tang, B; Wang, M1
Agnihotri, N; Kumar, S; Sharma, S1
Huang, C; Li, G; Li, Y; Suo, M; Tang, BZ; Xia, L; Xu, Y; Zhang, T; Zhu, D1
Cao, Y; Liao, W; Liu, N; Shi, F; Yang, L1
Audrito, V; Centonze, G; Coco, M; Cucinelli, S; Dalmasso, A; Defilippi, P; La Vecchia, S; Natalini, D; Orso, F; Paradzik, M; Quirico, L; Riganti, C; Taverna, D1
Joo, CG; Kang, J; Kim, TI; Seo, Y1
Le, A; Quinones, A; Zhang, C1
Madrigal Perez, LA; Nava, GM1
Bissonnette, MB; Chen, D; Chen, J; DeBerardinis, RJ; Elf, SE; Fan, H; Faubert, B; Gao, X; He, YY; Qu, CK; Tu, J; Wang, M; Wu, R; Zhang, FQ; Zhang, R; Zheng, H1
Hori, N; Kawamura, T; Takakura, Y; Takano, H; Takehora, Y; Yamaguchi, N1
Wu, Y; Zhu, L; Zhu, X1
Cai, Q; Chen, N; Dai, H; Di, C; Feng, J; Feng, R; Gou, X; Huang, J; Huang, M; Li, J; Li, Y; Liang, Z; Liu, J; Liu, S; Liu, X; Liu, Z; Lu, Y; Ma, L; Pan, J; Ruan, P; Su, S; Wang, J; Xia, Q; Ye, Y; Yu, S; Zhang, G; Zhao, Q; Zhou, B1
Chakravarti, A; Cheng, C; Cheng, X; Duan, W; Geng, F; Guo, D; Horbinski, C; Li, Z; Mo, X; Wang, H; Zhao, Y; Zhong, Y1
Briot, C; Freidman, NJ; Ryan, RM1
Aburatani, H; Candeias, MM; Ishiguro, K; Ishikawa, T; Kato, M; Lafontaine, DLJ; Matsumura, Y; Nishida, M; Okamoto, A; Osawa, T; Pan, M; Proud, CG; Sakai, J; Soga, T; Sugaya, M; Suzuki, T; Zhang, HF; Zorbas, C1
Crescenzi, E; D'Incalci, M; Leonardi, A; Mellone, S; Pacifico, F; Stornaiuolo, M1
Chen, B; Liu, W; Tang, BZ; Wang, D; Wang, L; Wen, H; Xiao, P; Xie, W1
Chen, Y; Li, D; Li, P; Liang, Y; Liang, Z; Ma, G; Niu, H; Wang, L; Zeng, M; Zhang, Z1
Estok, TM; Wild, R; Yokoyama, Y1
Albertini, E; Damisch, E; Fiegl, H; Guerrero-Navarro, L; Holzknecht, M; Jansen-Duerr, P; Parson, W; Petit, M; Schmitt, F; Simonini, A; Weiss, A1
Dasgupta, S; Kalhotra, P; Novickis, AT; Sawant Dessai, A1
DeBerardinis, RJ; Do, D; Faubert, B; Gu, W; Kaushik, AK; Ko, B; LaVigne, CA; Martin-Sandoval, MS; Mathews, TP; Mishra, P; Morrison, SJ; Pachnis, P; Ramesh, V; Rao, AD; Rogers, TJ; Shelton, S; Solmonson, A; Sudderth, J; Tasdogan, A; Ubellacker, JM; Wu, Z; Yang, C; Zacharias, LG; Zhao, Z1
Calder, PC; Douglas, C; McCullough, FS; Miller, LJ; Stanworth, SJ1
Chen, M; Li, M; Lin, Z; Qin, X; Shi, J; Xu, F; Ye, J; Zheng, Z1
Imai, T; Matsuhashi, N; Okumura, N; Sato, Y; Shimokawa, T; Takahashi, T; Tanaka, Y; Yoshida, K1
Archilla, I; Benítez-Ribas, D; Camps, J; Cascante, M; Castells, A; Cuatrecasas, M; de Herreros, MG; Foguet, C; Maurel, J; Oliveres, H; Pedrosa, L; Postigo, A; Prat, A; Rodríguez, A; Thomson, TM1
Bai, C; Fang, M; He, Z; Huang, L; Jiang, Q; Jin, C; Lu, S; Qin, F; Sun, J; Wang, Y; Xu, X; Yan, Q; Zhang, T; Zhang, Y; Zhao, C1
Foster, DA; Frias, MA; Hatipoglu, A; Levy, T; Menon, D1
Ackermann, T; Allega, MF; Bird, TG; Blancke, G; Bloom, A; Blyth, K; Deshmukh, R; Drake, TM; Huang, DT; Jans, M; Lewis, DY; May, S; Müller, M; Murphy, DJ; Nakasone, MA; Nixon, C; Oetjen, J; Sansom, OJ; Sumpton, D; Tan, EH; Tardito, S; Vande Voorde, J; Vereecke, L; Villar, VH1
Celiku, O; Friedenberg, MD; Gilbert, MR; Larion, M; Lita, A1
Aguilar, JMH; Alt, J; Arwood, ML; Dash, RP; Lam, J; Lemberg, KM; Leone, RD; Majer, P; Pal, A; Pandey, R; Peters, DE; Powell, JD; Rais, R; Seiwert, T; Slusher, BS; Tallon, C; Tenora, L; Thomas, AG; Wu, Y; Zhao, L1
Baek, S; Jang, Y; Joo, S; Kang, J; Kwon, TK; Seo, DS1
Bajgain, P; Cuttitta, F; Dimitrov, DS; Dunleavey, JM; Emenaker, NJ; Feng, Y; Hilton, MB; Hsu, KS; Koogle, R; Lutz, EM; Morris, K; Rose, J; Saha, S; Seaman, S; St Croix, B; Szot, C; Tessarollo, L; Tomassoni-Ardori, F; Yang, L; Zhang, XM; Zhu, Z; Zudaire, E1
Barnes, S; Benavides, GA; Darley-Usmar, VM; Johnson, MS; Tian, R; Xing, D1
Chomiczewska, A; Hallmann, A; Lipiński, M; Michnowska, A; Smolarz, K1
Li, H; Mao, H; Sun, B; Wang, J; Wen, Y; Yu, Y1
Chuang, YC; Kao, TW; Kuo, CC; Lee, HL; Shen, YA1
Peng-Fei, S; Xiao-Xia, Y; Xiao-Yan, W; Xiu-Li, G; Zong-Xue, Z1
Chae, HS; Hong, ST1
Bian, J; Chen, R; Gong, G; Guo, Z; Huang, H; Li, X; Li, Z; Lu, Y; Wang, D1
Amiri Khosroshahi, R; Imani, H; Mohammadi, H; Rashidi, A; Talebi, S; Travica, N; Zeraattalab-Motlagh, S1
Crescenzi, E; Leonardi, A; Pacifico, F1
Amere Subbarao, S; Dharaskar, SP1
Antsaklis, P; Chionis, A; Daskalakis, G; Fasoulakis, Z; Katrachouras, A; Konis, K; Kontomanolis, EN; Koutras, A; Nikolettos, K; Ntounis, T; Pagkalos, A; Palios, VC; Perros, P; Prokopakis, I; Samara, AA; Sapantzoglou, I; Sotiriou, S; Symeonidis, P; Theodora, M; Valsamaki, A1
de Menêses, AG; Dos Reis, PED; E Vasconcelos, SCCM; Ferreira, EB; Guerra, ENS1
Byun, JK; Choi, YK; Jin, J; Park, KG1
Cheng, Z; Han, T; Hu, Q; Li, D; Li, Y; Wang, K; Yao, L; Yuan, Y1
Li, N; Liu, X; Pan, W; Shi, M; Tang, B; Wang, K; Wang, M; Wei, R; Zhang, H; Zhang, X1
Aceto, G; Adams, BN; Avizonis, DZ; Chen, SY; Ching, K; Choiniere, L; Foulkes, WD; Fu, L; Fu, Z; Ho, R; Huang, S; Huntsman, DG; Klein Geltink, RI; Li, E; Monast, A; Morin, GB; Negri, GL; Ong, D; Park, M; Pavlakis, K; Pilon, V; Pirrotte, P; Steinberger, J; Ta, M; Trent, J; Wang, Y; Weissman, BE; Zhu, X1
De, K; Mukhopadhyay, S; Prasad, P; Roy, SS; Sinha, S1
Dai, L; Du, H; Geng, M; Gong, L; Li, X; Meng, S; Yang, H; Yuan, Z; Zhao, P; Zhao, Y; Zheng, X1
Bader, JE; Chi, C; Fisher, EL; Hathaway, ES; Karijolich, J; Landis, MD; Madden, MZ; Muka, JE; Needle, GA; O'Neil, RT; Patterson, AR; Philip, M; Rathmell, JC; Reinfeld, BI; Wolf, MM; Ye, X1
Chapman, NM; Chi, H; Dhungana, Y; Du, X; Guo, C; Guy, C; Lim, SA; Palacios, G; Rankin, S; Saravia, J; Shi, H; Sun, X; Sun, Y; You, Z; Yuan, S1
Balieiro, JCC; Bonder, BSA; Brunetto, MA; de-Oliveira, CM; Fantoni, DT; Gonçales, LA; Massoco, CO; Nagashima, JK; Pfrimer, K; Pontieri, CFF; Porsani, MYH; Teixeira, FA1
Ai, C; Guo, L; Li, J; Meng, D; Shang, M; Shi, D; Sun, X; Wang, X; Xiao, S; Zhao, Y1
Byrne, HJ; Cahill, P; Howe, O; Mirveis, Z; Patil, N1
Gu, Z; Han, M; Han, Y; Hu, C; Li, Z; Wang, L1
Arpaci, T; Semerci, R; Yılmaz, P1
Araújo Júnior, RF; Araújo, AA; Clebis, NK; Fracaro, L; Lacchini, S; Lima, KRA; Lima, MFO; Lins, LAA; Lopes, MLDS; Perles, JVCM; Purificação, NRCD; Souza, SRG; Zanoni, JN1
Alt, J; Gori, S; Lam, J; Majer, P; Mettu, VS; Novotná, K; Paule, J; Prchalová, E; Rais, R; Slusher, BS; Šnajdr, I; Tenora, L; Tsukamoto, T; Veeravalli, V; Wu, Y1
Hoang, G; Le, A; Udupa, S1
Al-Nawas, B; Bache, M; Bull, F; Eckert, AW; Grosse, I; Güttler, A; Kappler, M; Kaune, T; Kotrba, J; Krohn, K; Pabst, U; Porsch, M; Riemann, A; Rot, S; Schubert, J; Seliger, B; Taubert, H; Thews, O; Vordermark, D; Weinholdt, C; Wickenhauser, C1
Curtin, NJ; Unterlass, JE1
Lulli, M; Nencioni, D; Papucci, L; Schiavone, N1
Boroughs, L; Britt, R; Byers, LA; Cai, L; Chen, D; Chen, J; Chen, PH; DeBerardinis, RJ; Faubert, B; Girard, L; Heymach, JV; Huffman, K; Kim, HS; Kim, J; Ko, B; McMillan, EA; Minna, JD; Peyton, M; Sekine, I; Shames, DS; Shields, MD; Sudderth, J; Timmons, B; Weber, S; White, MA; Xiao, G; Yang, C; Yao, B1
Campos-Sandoval, JA; Márquez, J; Matés, JM; Santos-Jiménez, JL1
Bordon, Y1
Brusa, D; Corbet, C; Feron, O; Gallez, B; Joudiou, N; Schoonjans, CA1
Aranda, E; López-Sánchez, LM; Rodríguez-Ariza, A1
Dang, CV; Stine, ZE2
Bang, S; Choi, J; Han, JM; Heo, Y; Hwang, GS; Kang, J; Kang, JS; Kim, JK; Kim, K; Kim, YH; Lee, CW; Lee, HS; Lee, J; Lee, MY; Nam, M; Park, SJ; Yeo, JH; Yoo, HC1
Huang, H; Li, S; Liu, Y; Luo, Z; Ma, W; Pardeshi, A; Sun, J; Wan, Z; Xu, J; Zhang, Z1
Bai, C; Chen, C; Chu, Q; Cui, Y; Li, B; Liu, M; Ruan, Y; Wang, Y; Yang, C; Ying, G1
Diehl, JA; Qie, S1
DeBerardinis, RJ1
Chen, CJ; Chen, WY; Ko, CC; Li, JR; Liao, SL; Lin, SY; Wang, JD; Wang, YY; Wu, CC1
Bamba, T; Izumi, Y; Kodama, M; Matsumoto, M; Nakayama, KI; Oshikawa, K; Shimizu, H; Takahashi, M; Tateishi, C; Tomonaga, T; Yoshioka, S1
Chevet, E; Eldering, E; Favaro, F; Iurlaro, R; Lucendo, E; Majem, B; Marchetti, S; Muñoz-Pinedo, C; Nadal, E; Püschel, F; Redondo-Pedraza, J; Ricci, JE1
Chiellini, G1
Contreras-Paredes, A; Langley, E; Lizano, M; Martínez-Ramírez, I; Muñoz-Bello, JO; Olmedo-Nieva, L; Ortiz-Pedraza, Y1
Chen, J; Chen, X; Gao, W; Hao, B; Huang, M; Huang, W; Li, K; Liu, J; Liu, Q; Liu, R; Shao, Y; Wang, J; Wang, Q; Wei, Z; Xu, P; Xu, Y; Ye, S; Zeng, S; Zhang, H; Zhang, Q; Zhong, Z1
Dey, S; Ghosh, P; Vidal, C; Zhang, L1
Kery, M; Papandreou, I1
Cocetta, V; Montopoli, M; Ragazzi, E1
Anderson, PM; Lalla, RV1
Huo, YY; Li, NY; Liu, M; Pan, YH; Sun, YP; Xu, W1
Campos-Sandoval, JA; de Los Santos-Jiménez, J; Márquez, J; Matés, JM1
Bridges, EM; Cunningham, C; Ellis, M; Fan, SJ; Goberdhan, DC; Hamdy, FC; Harris, AL; Johnson, E; Khalid Alham, N; Kroeger, B; Marie, PP; Mason, JD; McCormick, K; Mendes, CC; Morris, JF; Sheldon, H; Stefana, MI; Wainwright, SM; Wilson, C; Zois, CE1
Théry, C; van Niel, G1
Endo, H; Inagaki, Y; Owada, S; Shida, Y; Tatemichi, M1
Aasen, T; Abdul Moin, NI; Abdul Wafi, S; Aboukameel, A; Abu-Bakar, N; Acharya, A; Ackermans, L; Adaramoye, O; Adarsh, KV; Adeosun, WA; Ahmad, NH; Ahmadi, F; Akanni, O; Akbar, M; Akbulak, RO; Akev, N; Akkaya, Ö; Al-Rashed, S; AlAbbad, S; Alabi, O; Alappat, BJ; Alcalá, S; Alcoutlabi, M; Aleppo, G; Alexander Ross, JB; Alexander, JH; Alexander, R; Alias, A; Alimba, C; Alken, FA; Allan, R; Alpers, M; Alsbou, EM; Amarasiri, SS; An, T; Anastasiadis, F; Anastassiadou, M; Anderson, KC; Andronikos, P; Anheyer, D; Annapurna, K; Anorlu, RI; Anten, MM; Anthopoulos, TD; Araujo-Castillo, RV; Aravamudhan, S; Arawwawala, LDAM; Arulsamy, N; Arunamata, A; Asghar, A; Asiri, AM; Aslanidou, T; Astrakhantseva, IV; Astutik, E; Attanayake, AP; Atwater, BD; Audureau, E; Augusto, S; Bakare, A; Banach, M; Bandelier, P; Banerjee, S; Barral, M; Bascuñán, J; Bates, FS; Bauer, NJC; Bayrak, BB; Beck, RW; Beckervordersantforth, J; Beeri, R; Begum, R; Beldi-Ferchiou, A; Bellingham, G; Ben-Tal, N; Bendib, I; Bergenstal, RM; Berger, MF; Bernasconi, G; Berry, S; Beuvon, F; Bi, WJ; Bi, Z; Bianconi, V; Bibi, I; Blank, BR; Bliemeister, E; Bobkowski, W; Bode, AM; Booth, CM; Bose, U; Boyd, K; Brancato, A; Brenmoehl, J; Brogi, E; Bronzo, P; Brooks, T; Brown, D; Brown, DN; Bruce, D; Buan, MEM; Bueno-Hernández, F; Bugielski, B; Bulavaitė, A; Buscagan, TM; Buxton, R; Caffaro, MM; Cai, Q; Cai, X; Cai, Y; Calhoun, P; Callander, N; Cambier, S; Camparo, P; Canales-Vargas, EJ; Canham, K; Cantu, J; Cao, J; Cao, JW; Cao, P; Cao, T; Cao, X; Caravella, BA; Carcadea, E; Carè, J; Carmichael, P; Carrasco Cabrera, L; Carteaux, G; Carvalho, PDS; Casarez, E; Cazorla, M; Celestrin, CP; Chakraborty, NK; Chan, B; Chandarlapaty, S; Chandgude, AL; Chang, CC; Chang, JH; Chang, X; Chang, Y; Chankhanittha, T; Chantanis, S; Chapovetsky, A; Chavan, S; Chen, B; Chen, D; Chen, F; Chen, G; Chen, H; Chen, J; Chen, K; Chen, KJ; Chen, KP; Chen, L; Chen, MA; Chen, Q; Chen, S; Chen, W; Chen, WF; Chen, X; Chen, Y; Cheng, D; Cheng, J; Cheng, Q; Cheon, GJ; Chiu, SC; Cho, CH; Cho, J; Choi, H; Choi, JS; Choi, YH; Christie, P; Chu, CH; Chu, Y; Chung, DH; Chung, F; Cline, JP; Cohen, A; Cohen, AD; Cohen, NJ; Comen, E; Compter, I; Cong, J; Cong, Z; Cooper, A; Cornud, F; Costa, C; Costa, S; Covey, A; Cowan, AM; Cramer, H; Cruz-Rivera, C; Cui, J; Cui, M; Cui, Y; Cui, YH; Culquichicón, C; Cushman, T; D'Auria, SJ; da Silva, J; Dalgediene, I; Danenberg, HD; Das, S; Dasgupta, K; Daubit, IM; de Oliveira, PD; de Prost, N; De Ruysscher, D; Dearman, K; Decato, D; Delfau-Larue, MH; Deng, L; Dhakate, SR; Dharuman, V; Di Costanzo, N; Dickler, MN; Dinehart, EE; Ding, D; Dinh, TK; Divya, KP; Djifack Tadongfack, T; Do, T; Domínguez-Roldan, R; Domínguez-Zambrano, E; Dömling, A; Donato, MD; Dong, JH; Dong, W; Dong, X; Dong, XR; Dong, Y; Dong, Z; Downs, M; Drutskaya, MS; Du, B; Du, F; Du, H; Du, L; Du, X; Duan, Z; Duangthip, D; Dunstand-Guzmán, E; Duong, F; Eckert, DJ; Edelhäuser, BAH; Eekers, DBP; Efendi, F; Efraimidis, P; Ehrenberg, H; Ehsanbakhsh, Z; Eickholt, C; Eksterowicz, J; El Mobadder, M; El-Araby, IE; El-Magd, MA; El-Tarabany, MS; Elgorban, AM; Engelmann, D; English, KL; Esfandiari, H; Eslami, B; Espinosa-Cuevas, A; Eswara, S; Faber, E; Fan, XH; Fan, Y; Fang, J; Fang, Z; Fantin, VR; Fei, P; Feng, G; Feng, H; Feng, J; Feng, X; Feng, XJ; Fennell, TR; Fernández-Moreira, V; Ferraz, ABF; Ferreras, KN; Flores, K; Flores-Pérez, I; Flox, C; Fluharty, FL; Fokouong Tchoffo, E; Folefack, GO; Foroutan, T; Fort, D; Fourati, S; Fousas, S; Frapard, T; Freguia, S; Friedman, DJ; Friedman, LS; Fu, D; Fu, Q; Fu, Y; Fujinami, S; Furihata, K; Gal, RL; Gan, H; Gao, C; Gao, F; Gao, R; Gao, SS; Gao, W; Gao, XC; Gao, Y; Gao, Z; Garozi, L; Ge, J; Georgiopoulos, A; Gerakiou, K; Ghazimirsaeed, SM; Ghazimirsaeed, ST; Gimeno, MC; Gjestad, R; Glurich, I; Goetchius, E; Goland, S; Goldstein, S; Gonçalves, CM; Gonçalves, H; Gong, Q; Gonzalez, D; Goplen, FK; Gorshkova, EN; Gotsman, I; Govindasamy, V; Granger, CB; Greco, L; Grigoriadou-Skouta, E; Grigoropoulos, P; Grivicich, I; 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6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
    Nature cell biology, 2015, Volume: 17, Issue:11

    Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Humans; Lipogenesis; Neoplasms; Oxidative Stress; Pentose Phosphate Pathway; Phosphogluconate Dehydrogenase; Protein Serine-Threonine Kinases; Ribulosephosphates; Signal Transduction

2015
Pharmacologic approaches to amino acid depletion for cancer therapy.
    Molecular carcinogenesis, 2022, Volume: 61, Issue:2

    Topics: Amino Acids; Arginine; Glutamine; Humans; Neoplasms; Oxidation-Reduction

2022
Functional Amino Acids and Autophagy: Diverse Signal Transduction and Application.
    International journal of molecular sciences, 2021, Oct-22, Volume: 22, Issue:21

    Topics: Aging; Amino Acids; Arginine; Autophagy; Glutamine; Humans; Leucine; Mechanistic Target of Rapamycin Complex 1; Methionine; Neoplasms; Neurodegenerative Diseases; Obesity; Signal Transduction

2021
A Narrative Review about Nutritional Management and Prevention of Oral Mucositis in Haematology and Oncology Cancer Patients Undergoing Antineoplastic Treatments.
    Nutrients, 2021, Nov-15, Volume: 13, Issue:11

    Topics: Adult; Antineoplastic Agents; Child; Dietary Supplements; Female; Glutamine; Honey; Humans; Male; Neoplasms; Stomatitis; Treatment Outcome; Vitamins

2021
Autophagy in cancer: The cornerstone during glutamine deprivation.
    European journal of pharmacology, 2022, Feb-05, Volume: 916

    Topics: Autophagy; Glutamine; Homeostasis; Humans; Neoplasms; Oxidation-Reduction

2022
Targeting fuel pocket of cancer cell metabolism: A focus on glutaminolysis.
    Biochemical pharmacology, 2022, Volume: 198

    Topics: Cell Transformation, Neoplastic; Citric Acid Cycle; Glutamine; Humans; Metabolic Networks and Pathways; Neoplasms; Tumor Microenvironment

2022
Oncogenic viral infection and amino acid metabolism in cancer progression: Molecular insights and clinical implications.
    Biochimica et biophysica acta. Reviews on cancer, 2022, Volume: 1877, Issue:3

    Topics: Amino Acids; Glutamine; Humans; Neoplasms; Oncogenic Viruses

2022
miRNA-guided reprogramming of glucose and glutamine metabolism and its impact on cell adhesion/migration during solid tumor progression.
    Cellular and molecular life sciences : CMLS, 2022, Mar-29, Volume: 79, Issue:4

    Topics: Cell Adhesion; Cell Movement; Glucose; Glutamine; Humans; MicroRNAs; Neoplasms

2022
Metabolic reservoir cycles in cancer.
    Seminars in cancer biology, 2022, Volume: 86, Issue:Pt 3

    Topics: Glutamic Acid; Glutamine; Glycogen; Humans; Lactic Acid; Neoplasms; Triglycerides

2022
Metabolic profile of the Warburg effect as a tool for molecular prognosis and diagnosis of cancer.
    Expert review of molecular diagnostics, 2022, Volume: 22, Issue:4

    Topics: Amino Acids, Branched-Chain; Glucose; Glutamine; Humans; Metabolome; Neoplasms; Proline

2022
Effects of Glucose Metabolism, Lipid Metabolism, and Glutamine Metabolism on Tumor Microenvironment and Clinical Implications.
    Biomolecules, 2022, 04-14, Volume: 12, Issue:4

    Topics: Glucose; Glutamine; Humans; Lipid Metabolism; Myeloid-Derived Suppressor Cells; Neoplasms; Tumor Microenvironment

2022
Reprogramming of glutamine metabolism and its impact on immune response in the tumor microenvironment.
    Cell communication and signaling : CCS, 2022, 07-27, Volume: 20, Issue:1

    Topics: Glutamine; Humans; Immunity; Immunotherapy; Neoplasms; Tumor Microenvironment

2022
Regulation of tumor metabolism by post translational modifications on metabolic enzymes.
    Cancer gene therapy, 2023, Volume: 30, Issue:4

    Topics: Citric Acid Cycle; Glutamine; Glycolysis; Humans; Neoplasms; Protein Processing, Post-Translational; Tumor Microenvironment

2023
Impact of enteral immunonutrition on infectious complications and immune and inflammatory markers in cancer patients undergoing chemotherapy: A systematic review of randomised controlled trials.
    Clinical nutrition (Edinburgh, Scotland), 2022, Volume: 41, Issue:10

    Topics: Adult; Arginine; Biomarkers; Fatty Acids, Omega-3; Glutamine; Humans; Malnutrition; Neoplasms; Nucleotides; Randomized Controlled Trials as Topic; Tumor Necrosis Factor-alpha; Vitamin A; Vitamins

2022
Hormone-Glutamine Metabolism: A Critical Regulatory Axis in Endocrine-Related Cancers.
    International journal of molecular sciences, 2022, Sep-03, Volume: 23, Issue:17

    Topics: Endocrine Gland Neoplasms; Endocrine System; Glutamine; Humans; Insulin; Neoplasms; Thyroid Hormones

2022
Therapeutic Targeting of Glutaminolysis as a Novel Strategy to Combat Cancer Stem Cells.
    International journal of molecular sciences, 2022, Dec-04, Volume: 23, Issue:23

    Topics: Glucose; Glutamic Acid; Glutaminase; Glutamine; Humans; Neoplasms; Neoplastic Stem Cells

2022
Metabolic reprogramming of glutamine involved in tumorigenesis, multidrug resistance and tumor immunity.
    European journal of pharmacology, 2023, Feb-05, Volume: 940

    Topics: Amino Acids; Cell Transformation, Neoplastic; Drug Resistance, Multiple; Glutamine; Humans; Neoplasms

2023
Overview of Cancer Metabolism and Signaling Transduction.
    International journal of molecular sciences, 2022, Dec-20, Volume: 24, Issue:1

    Topics: Energy Metabolism; Glucose; Glutamine; Glycolysis; Humans; Neoplasms; Signal Transduction

2022
An updated patent review of glutaminase inhibitors (2019-2022).
    Expert opinion on therapeutic patents, 2023, Volume: 33, Issue:1

    Topics: Enzyme Inhibitors; Glutaminase; Glutamine; Humans; Neoplasms; Patents as Topic

2023
Nutritional interventions for the prevention and treatment of cancer therapy-induced oral mucositis: an umbrella review of systematic reviews and meta-analysis.
    Nutrition reviews, 2023, 08-10, Volume: 81, Issue:9

    Topics: Glutamine; Humans; Meta-Analysis as Topic; Neoplasms; Propolis; Stomatitis; Systematic Reviews as Topic

2023
Glutamine Metabolism in Cancer Stem Cells: A Complex Liaison in the Tumor Microenvironment.
    International journal of molecular sciences, 2023, Jan-25, Volume: 24, Issue:3

    Topics: Glutamine; Humans; Metabolic Networks and Pathways; Neoplasms; Neoplastic Stem Cells; Tumor Microenvironment

2023
Ovarian Cancer and Glutamine Metabolism.
    International journal of molecular sciences, 2023, Mar-06, Volume: 24, Issue:5

    Topics: Energy Metabolism; Female; Glutamine; Glycolysis; Humans; Neoplasms; Ovarian Neoplasms

2023
Effects of oral supplementation to manage radiation dermatitis in cancer patients: a systematic review.
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2023, Mar-28, Volume: 31, Issue:4

    Topics: Dietary Supplements; Glutamine; Humans; Neoplasms; Radiodermatitis

2023
Targeting glutamine metabolism as a therapeutic strategy for cancer.
    Experimental & molecular medicine, 2023, Volume: 55, Issue:4

    Topics: Amino Acids; Citric Acid Cycle; Glutamine; Humans; Neoplasms; Oxidation-Reduction; Tumor Microenvironment

2023
Amino acid metabolism regulated by lncRNAs: the propellant behind cancer metabolic reprogramming.
    Cell communication and signaling : CCS, 2023, 05-01, Volume: 21, Issue:1

    Topics: Epigenesis, Genetic; Glutamine; Humans; Neoplasms; Protein Processing, Post-Translational; RNA, Long Noncoding

2023
Monitoring and modelling the glutamine metabolic pathway: a review and future perspectives.
    Metabolomics : Official journal of the Metabolomic Society, 2023, 07-23, Volume: 19, Issue:8

    Topics: Energy Metabolism; Glutamine; Humans; Metabolic Networks and Pathways; Metabolomics; Neoplasms

2023
Warburg and Krebs and related effects in cancer.
    Expert reviews in molecular medicine, 2019, 09-27, Volume: 21

    Topics: Animals; Glucose; Glutamine; Humans; Neoplasms; Phenotype; Tumor Microenvironment

2019
Zeta-crystallin: a moonlighting player in cancer.
    Cellular and molecular life sciences : CMLS, 2020, Volume: 77, Issue:6

    Topics: Acidosis; Ammonia; Animals; Apoptosis; Glutamine; Humans; Neoplasms; Oxidative Stress; Protein Binding; RNA, Messenger; zeta-Crystallins

2020
Dysregulation of glutaminase and glutamine synthetase in cancer.
    Cancer letters, 2019, 12-28, Volume: 467

    Topics: Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Glycolysis; Humans; Neoplasms; Tumor Microenvironment

2019
Nitric oxide and tumor metabolic reprogramming.
    Biochemical pharmacology, 2020, Volume: 176

    Topics: Cell Proliferation; Energy Metabolism; Glucose; Glutamine; Humans; Mitochondria; Neoplasms; Nitric Oxide; Signal Transduction; Tumor Microenvironment

2020
Cyclin D degradation by E3 ligases in cancer progression and treatment.
    Seminars in cancer biology, 2020, Volume: 67, Issue:Pt 2

    Topics: Cyclin D; Drug Resistance, Neoplasm; F-Box Proteins; Glutamine; Humans; Molecular Targeted Therapy; Neoplasms; Ubiquitin Thiolesterase; Ubiquitin-Protein Ligases; Ubiquitination

2020
Non-Coding RNAs as Key Regulators of Glutaminolysis in Cancer.
    International journal of molecular sciences, 2020, Apr-20, Volume: 21, Issue:8

    Topics: Animals; Antineoplastic Agents; Gene Expression Regulation, Neoplastic; Glutamine; Humans; Metabolic Networks and Pathways; MicroRNAs; Molecular Targeted Therapy; Neoplasms; RNA Interference; RNA, Circular; RNA, Untranslated

2020
Mitochondria Targeting as an Effective Strategy for Cancer Therapy.
    International journal of molecular sciences, 2020, May-09, Volume: 21, Issue:9

    Topics: Antimetabolites, Antineoplastic; Citric Acid Cycle; Drug Resistance, Neoplasm; Dynamins; Energy Metabolism; Glutamine; Glycolysis; GTP Phosphohydrolases; Heme; Humans; Mitochondria; Mitochondrial Dynamics; Mitochondrial Proteins; Molecular Targeted Therapy; Neoplasm Proteins; Neoplasms; Oxidative Phosphorylation; Oxidative Stress; Tumor Microenvironment

2020
Emerging strategies to target cancer metabolism and improve radiation therapy outcomes.
    The British journal of radiology, 2020, Nov-01, Volume: 93, Issue:1115

    Topics: Adaptation, Physiological; Animals; Ataxia Telangiectasia Mutated Proteins; DNA; DNA Damage; DNA Repair; Genomic Instability; Glutamine; Glutarates; Glutathione; Humans; Immunotherapy; Isocitrate Dehydrogenase; Ketoglutaric Acids; Lipid Peroxidation; Mice; Neoplasms; Nucleotides; Oxygen Consumption; Phospholipids; Radiation Tolerance; Radiation-Sensitizing Agents; Reactive Oxygen Species; Stress, Physiological; Treatment Outcome; Tumor Microenvironment

2020
Links between cancer metabolism and cisplatin resistance.
    International review of cell and molecular biology, 2020, Volume: 354

    Topics: Amino Acids; Animals; Antineoplastic Agents; Cisplatin; Drug Resistance, Neoplasm; Glutamine; Glycolysis; Humans; Mitochondria; Neoplasms

2020
Glutamine for Amelioration of Radiation and Chemotherapy Associated Mucositis during Cancer Therapy.
    Nutrients, 2020, Jun-04, Volume: 12, Issue:6

    Topics: Antineoplastic Agents; Diet, High-Protein; Dietary Proteins; Dietary Sucrose; Dietary Supplements; Glutamine; Humans; Malnutrition; Mucositis; Mucous Membrane; Neoplasms; Radiotherapy; Trehalose; Wound Healing

2020
Glutaminases regulate glutathione and oxidative stress in cancer.
    Archives of toxicology, 2020, Volume: 94, Issue:8

    Topics: Animals; Antineoplastic Agents; Antioxidants; Energy Metabolism; Enzyme Inhibitors; Glutamic Acid; Glutaminase; Glutamine; Glutathione; Humans; Mitochondria; Neoplasms; Oxidative Stress; Signal Transduction; Tumor Microenvironment

2020
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
    Annales medico-psychologiques, 2021, Volume: 179, Issue:2

    Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acrylic Resins; Actinobacillus; Acute Disease; Acute Kidney Injury; Adaptor Proteins, Signal Transducing; Adenosine; Adenosine Triphosphate; Administration, Inhalation; Administration, Oral; Adolescent; Adult; Advance Care Planning; Africa, Northern; Age Factors; Aged; Aged, 80 and over; Air Pollutants; Air Pollution; Air Pollution, Indoor; Albendazole; Aluminum Oxide; Anastomosis, Surgical; Ancylostoma; Ancylostomiasis; Androstadienes; Angiogenesis Inhibitors; Angiotensin II; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Antibodies, Bispecific; Antibodies, Viral; Anticoagulants; Antihypertensive Agents; Antinematodal Agents; Antineoplastic Agents; Antineoplastic Agents, Immunological; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Antiporters; Antiviral Agents; Apoptosis; Aptamers, Nucleotide; Aromatase Inhibitors; Asian People; Astrocytes; Atrial Fibrillation; Auditory Threshold; Aurora Kinase B; Australia; Autophagy; Autophagy-Related Protein 5; Autotrophic Processes; Bacillus cereus; Bacillus thuringiensis; Bacterial Proteins; Beclin-1; Belgium; Benzene; Benzene Derivatives; Benzhydryl Compounds; beta Catenin; beta-Arrestin 2; Biliary Tract Diseases; Biofilms; Biofuels; Biomarkers; Biomarkers, Tumor; Biomass; Biomechanical Phenomena; Bioreactors; Biosensing Techniques; Biosynthetic Pathways; Bismuth; Blood Platelets; Bone and Bones; Bone Regeneration; Bortezomib; Botulinum Toxins, Type A; Brain; Brain Injuries; Brain Ischemia; Brain Neoplasms; Breast Neoplasms; Breath Tests; Bronchodilator Agents; Calcium Phosphates; Cannabis; Carbon Dioxide; Carbon Isotopes; Carcinogenesis; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cardiac Resynchronization Therapy; Cardiac Resynchronization Therapy Devices; Cardiomyopathies; Cardiovascular Diseases; Cariostatic Agents; Case Managers; Case-Control Studies; Catalysis; Cation Transport Proteins; CD8-Positive T-Lymphocytes; Cecropia Plant; Cell Adhesion; Cell Count; Cell Differentiation; Cell Division; Cell Line; Cell Line, Tumor; Cell Membrane; Cell Movement; Cell Proliferation; Cell Self Renewal; Cell Survival; Cells, Cultured; Cellular Reprogramming; Cellulose; Charcoal; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chemokines; Chemoradiotherapy; Chemoreceptor Cells; Child; Child Abuse; Child, Preschool; China; Chlorogenic Acid; Chloroquine; Chromatography, Gas; Chronic Disease; Clinical Competence; Coated Materials, Biocompatible; Cochlea; Cohort Studies; Color; Comorbidity; Computer Simulation; Computer-Aided Design; Contraception; Contraceptive Agents, Female; Contrast Media; COP-Coated Vesicles; Coronavirus Infections; Cost of Illness; Coturnix; COVID-19; Creatinine; Cross-Over Studies; Cross-Sectional Studies; Culex; Curriculum; Cyclic N-Oxides; Cytokines; Cytoplasm; Cytotoxicity, Immunologic; Cytotoxins; Databases, Factual; Deep Learning; Delivery, Obstetric; Denitrification; Dental Caries; Denture, Complete; Dexamethasone; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dielectric Spectroscopy; Diet, High-Fat; Dietary Fiber; Disease Models, Animal; Disease Progression; DNA; DNA Copy Number Variations; DNA, Mitochondrial; Dog Diseases; Dogs; Dopaminergic Neurons; Double-Blind Method; Down-Regulation; Doxorubicin; Drug Carriers; Drug Design; Drug Interactions; Drug Resistance, Bacterial; Drug Resistance, Neoplasm; Drug-Related Side Effects and Adverse Reactions; Drugs, Chinese Herbal; Dry Powder Inhalers; Dust; E2F1 Transcription Factor; Ecosystem; Education, Nursing; Education, Nursing, Baccalaureate; Electric Impedance; Electricity; Electrocardiography; Electrochemical Techniques; Electrochemistry; Electrodes; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Endothelial Cells; Environmental Monitoring; Enzyme Inhibitors; Epithelial Cells; Epithelial-Mesenchymal Transition; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Estrogen Receptor Modulators; Europe; Evoked Potentials, Auditory, Brain Stem; Exosomes; Feasibility Studies; Female; Ferricyanides; Ferrocyanides; Fibrinogen; Finite Element Analysis; Fistula; Fluorescent Dyes; Fluorides, Topical; Fluorodeoxyglucose F18; Fluticasone; Follow-Up Studies; Food Contamination; Food Microbiology; Foods, Specialized; Forensic Medicine; Frail Elderly; France; Free Radicals; Fresh Water; Fungi; Fungicides, Industrial; Galactosamine; Gastrointestinal Neoplasms; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Frequency; Genetic Predisposition to Disease; Genotype; Gingival Hemorrhage; Glioblastoma; Glioma; Glomerular Filtration Rate; Glomerulosclerosis, Focal Segmental; Glucose; Glucose Transport Proteins, Facilitative; Glucosides; Glutamine; Glycolysis; Gold; GPI-Linked Proteins; Gram-Negative Bacteria; Gram-Positive Bacteria; Graphite; Haplotypes; HCT116 Cells; Healthy Volunteers; Hearing Loss; Heart Failure; Hedgehog Proteins; HEK293 Cells; HeLa Cells; Hemodynamics; Hemorrhage; Hepatocytes; Hippo Signaling Pathway; Histone Deacetylases; Homeostasis; Hospital Mortality; Hospitalization; Humans; Hydantoins; Hydrazines; Hydrogen Peroxide; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Hydroxylamines; Hypoglycemic Agents; Immunity, Innate; Immunoglobulin G; Immunohistochemistry; Immunologic Factors; Immunomodulation; Immunophenotyping; Immunotherapy; Incidence; Indazoles; Indonesia; Infant; Infant, Newborn; Infarction, Middle Cerebral Artery; Inflammation; Injections, Intramuscular; Insecticides; Insulin-Like Growth Factor I; Insurance, Health; Intention to Treat Analysis; Interleukin-1 Receptor-Associated Kinases; Interleukin-6; Intrauterine Devices; Intrauterine Devices, Copper; Iron; Ischemia; Jordan; Keratinocytes; Kidney; Kidney Diseases; Kir5.1 Channel; Klebsiella Infections; Klebsiella pneumoniae; Lab-On-A-Chip Devices; Laparoscopy; Lasers; Lasers, Semiconductor; Lenalidomide; Leptin; Lethal Dose 50; Levonorgestrel; Limit of Detection; Lipid Metabolism; Lipid Metabolism Disorders; Lipogenesis; Lipopolysaccharides; Liquid Biopsy; Liver; Liver Abscess, Pyogenic; Liver Cirrhosis; Liver Diseases; Liver Neoplasms; Longevity; Lung Neoplasms; Luteolin; Lymph Nodes; Lymphocyte Activation; Macaca fascicularis; Macrophages; Mad2 Proteins; Magnetic Resonance Imaging; Male; Mammary Glands, Human; Manganese; Manganese Compounds; MAP Kinase Signaling System; Materials Testing; Maternal Health Services; MCF-7 Cells; Medicaid; Medicine, Chinese Traditional; Melanoma; Membrane Proteins; Mental Health; Mercury; Metal Nanoparticles; Metals, Heavy; Metformin; Methionine Adenosyltransferase; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Knockout; Mice, Nude; Microalgae; Microbial Sensitivity Tests; Microglia; MicroRNAs; Microscopy, Atomic Force; Microscopy, Electron, Scanning; Middle Aged; Mitochondria; Mitochondrial Proteins; Mitral Valve; Mitral Valve Insufficiency; Models, Anatomic; Molecular Structure; Molybdenum; Monocarboxylic Acid Transporters; Moths; MPTP Poisoning; Multigene Family; Multiparametric Magnetic Resonance Imaging; Multiple Myeloma; Muscle, Skeletal; Mutagens; Mutation; Myeloid Cells; Nanocomposites; Nanofibers; Nanomedicine; Nanoparticles; Nanowires; Neoadjuvant Therapy; Neomycin; Neoplasm Grading; Neoplasm Recurrence, Local; Neoplasms; Neoplastic Stem Cells; Neostriatum; Neovascularization, Pathologic; Netherlands; Neuromuscular Agents; Neurons; NF-E2-Related Factor 2; NF-kappa B; Nickel; Nitrogen Oxides; Non-alcoholic Fatty Liver Disease; Nucleosides; Nucleotidyltransferases; Nutritional Status; Obesity, Morbid; Ofloxacin; Oils, Volatile; Oligopeptides; Oncogene Protein v-akt; Optical Imaging; Organic Cation Transport Proteins; Organophosphonates; Osteoarthritis; Osteoarthritis, Hip; Osteoarthritis, Knee; Osteoblasts; Osteogenesis; Oxidation-Reduction; Oxidative Stress; Oxides; Oxygen Isotopes; Pancreas; Pancreaticoduodenectomy; Pandemics; Particle Size; Particulate Matter; Patient Acceptance of Health Care; Patient Compliance; PC-3 Cells; Peptide Fragments; Peptides; Periodontal Attachment Loss; Periodontal Index; Periodontal Pocket; Periodontitis; Peroxides; Peru; Pest Control, Biological; Phosphatidylinositol 3-Kinase; Phosphatidylinositol 3-Kinases; Phylogeny; Pilot Projects; Piperidines; Plant Bark; Plant Extracts; Plant Leaves; Plasmids; Platelet Function Tests; Pneumonia, Viral; Podocytes; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Polyethylene Terephthalates; Polymers; Polymorphism, Single Nucleotide; Porosity; Portugal; Positron-Emission Tomography; Postoperative Complications; Postural Balance; Potassium Channels, Inwardly Rectifying; Povidone; Powders; Precancerous Conditions; Precision Medicine; Predictive Value of Tests; Pregnancy; Prenatal Care; Prognosis; Promoter Regions, Genetic; Prospective Studies; Prostatectomy; Prostatic Neoplasms; Proteasome Inhibitors; Protective Agents; Protein Binding; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein Transport; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-akt; Psychiatric Nursing; PTEN Phosphohydrolase; Pulmonary Embolism; Pyrimethamine; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Rats, Wistar; Reactive Oxygen Species; Receptor, ErbB-2; Receptor, IGF Type 1; Receptors, Estrogen; Receptors, G-Protein-Coupled; Recombinational DNA Repair; Recovery of Function; Regional Blood Flow; Renal Dialysis; Renin; Renin-Angiotensin System; Reperfusion Injury; Reproducibility of Results; Republic of Korea; Respiratory Distress Syndrome; Retrospective Studies; Rhodamines; Risk Assessment; Risk Factors; RNA, Long Noncoding; RNA, Messenger; Running; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Salinity; Salmeterol Xinafoate; Sarcoma; Seasons; Shoulder Injuries; Signal Transduction; Silicon Dioxide; Silver; Sirtuin 1; Sirtuins; Skull Fractures; Social Determinants of Health; Sodium; Sodium Fluoride; Sodium Potassium Chloride Symporter Inhibitors; Sodium-Glucose Transporter 2 Inhibitors; Soil; Soil Pollutants; Spain; Spectrophotometry; Spectroscopy, Fourier Transform Infrared; Staphylococcal Protein A; Staphylococcus aureus; Stem Cells; Stereoisomerism; Stomach Neoplasms; Streptomyces; Strontium; Structure-Activity Relationship; Students, Nursing; Substance-Related Disorders; Succinic Acid; Sulfur; Surface Properties; Survival Rate; Survivin; Symporters; T-Lymphocytes; Temozolomide; Tensile Strength; Thiazoles; Thiobacillus; Thiohydantoins; Thiourea; Thrombectomy; Time Factors; Titanium; Tobacco Mosaic Virus; Tobacco Use Disorder; Toll-Like Receptor 4; Toluene; Tomography, X-Ray Computed; TOR Serine-Threonine Kinases; Toxicity Tests, Acute; Toxicity Tests, Subacute; Transcriptional Activation; Treatment Outcome; Troponin I; Tumor Cells, Cultured; Tumor Escape; Tumor Hypoxia; Tumor Microenvironment; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha; Tyrosine; Ubiquitin-Protein Ligases; Ubiquitination; Ultrasonic Waves; United Kingdom; United States; United States Department of Veterans Affairs; Up-Regulation; Urea; Uric Acid; Urinary Bladder Neoplasms; Urinary Bladder, Neurogenic; Urine; Urodynamics; User-Computer Interface; Vemurafenib; Verbenaceae; Veterans; Veterans Health; Viral Load; Virtual Reality; Vitiligo; Water Pollutants, Chemical; Wildfires; Wnt Signaling Pathway; Wound Healing; X-Ray Diffraction; Xenograft Model Antitumor Assays; Xylenes; Young Adult; Zinc; Zinc Oxide; Zinc Sulfate; Zoonoses

2021
Glutamine reliance in cell metabolism.
    Experimental & molecular medicine, 2020, Volume: 52, Issue:9

    Topics: Animals; Cell Transformation, Neoplastic; Disease Susceptibility; Energy Metabolism; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Glutamine; Humans; Metabolic Networks and Pathways; Metabolome; Metabolomics; Neoplasms; Oxidation-Reduction; Signal Transduction

2020
Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy.
    Protein & cell, 2021, Volume: 12, Issue:8

    Topics: Amino Acid Transport System y+; Antineoplastic Agents; Cystine; DNA Methylation; Ferroptosis; Gene Expression Regulation, Neoplastic; Glucose; Glutamine; Glutathione; Histones; Humans; Molecular Targeted Therapy; Neoplasms; Piperazines; Signal Transduction; Sorafenib; Sulfasalazine

2021
A second Warburg-like effect in cancer metabolism: The metabolic shift of glutamine-derived nitrogen: A shift in glutamine-derived nitrogen metabolism from glutaminolysis to de novo nucleotide biosynthesis contributes to malignant evolution of cancer.
    BioEssays : news and reviews in molecular, cellular and developmental biology, 2020, Volume: 42, Issue:12

    Topics: Glutamine; Humans; Metabolic Networks and Pathways; Neoplasms; Nitrogen; Nucleotides

2020
Plant Proteins: Assessing Their Nutritional Quality and Effects on Health and Physical Function.
    Nutrients, 2020, Nov-30, Volume: 12, Issue:12

    Topics: Amino Acids, Essential; Animal Proteins, Dietary; Body Mass Index; Cardiovascular Diseases; Diabetes Mellitus; Diet, Vegetarian; Fatty Acids; Functional Food; Glutamine; Humans; Metabolic Diseases; Neoplasms; Nutritive Value; Plant Proteins; Risk Factors; Whey Proteins

2020
LKB1 deficiency-induced metabolic reprogramming in tumorigenesis and non-neoplastic diseases.
    Molecular metabolism, 2021, Volume: 44

    Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Animals; Apoptosis; Carcinogenesis; Energy Metabolism; Glucose; Glutamine; Humans; Lipid Metabolism; Lipids; Metabolic Engineering; Metabolic Networks and Pathways; Mutation; Neoplasms; Peutz-Jeghers Syndrome; Protein Serine-Threonine Kinases; Serine; Signal Transduction

2021
Hypoxia Dictates Metabolic Rewiring of Tumors: Implications for Chemoresistance.
    Cells, 2020, 12-04, Volume: 9, Issue:12

    Topics: Amino Acids; Animals; Citric Acid Cycle; Dimerization; Disease Progression; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; Glucose; Glutamine; Humans; Hypoxia; Lactic Acid; Mice; Mitochondria; Neoplasms; Oxidation-Reduction; Oxidative Phosphorylation; Oxygen; Phenotype; Reactive Oxygen Species; Tumor Microenvironment

2020
The metabolism of cancer cells during metastasis.
    Nature reviews. Cancer, 2021, Volume: 21, Issue:3

    Topics: Acetates; Adenosine Triphosphate; Animals; Cell Plasticity; Fatty Acids; Glutamine; Humans; Lactic Acid; Neoplasm Metastasis; Neoplasms; Neoplastic Cells, Circulating; Pyruvic Acid

2021
The role of the glutamine transporter ASCT2 in antineoplastic therapy.
    Cancer chemotherapy and pharmacology, 2021, Volume: 87, Issue:4

    Topics: Amino Acid Transport System ASC; Animals; Antibodies, Monoclonal; Glutamine; Humans; Minor Histocompatibility Antigens; Neoplasms; Oxidative Stress

2021
Host cell glutamine metabolism as a potential antiviral target.
    Clinical science (London, England : 1979), 2021, 01-29, Volume: 135, Issue:2

    Topics: Antiviral Agents; Cell Line, Tumor; Glutamine; Host-Pathogen Interactions; Humans; Metabolic Networks and Pathways; Neoplasms; Virulence; Virus Replication; Viruses

2021
Effectiveness of glutamine in the management of oral mucositis in cancer patients: a meta-analysis of randomized controlled trials.
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2021, Volume: 29, Issue:8

    Topics: Glutamine; Humans; Neoplasms; Prospective Studies; Randomized Controlled Trials as Topic; Stomatitis

2021
Role of Glutamine in the Management of Oral Mucositis in Patients with Cancer: A Meta-Analysis of Randomized Controlled Trials.
    Nutrition and cancer, 2022, Volume: 74, Issue:2

    Topics: Databases, Factual; Glutamine; Humans; Neoplasms; Randomized Controlled Trials as Topic; Stomatitis

2022
Krebs cycle: activators, inhibitors and their roles in the modulation of carcinogenesis.
    Archives of toxicology, 2021, Volume: 95, Issue:4

    Topics: Animals; Carcinogenesis; Citric Acid Cycle; Disease Progression; Energy Metabolism; Glucose; Glutamine; Glycolysis; Humans; L-Lactate Dehydrogenase; Neoplasms; Oxygen Consumption

2021
The emerging regulatory roles of long non-coding RNAs implicated in cancer metabolism.
    Molecular therapy : the journal of the American Society of Gene Therapy, 2021, 07-07, Volume: 29, Issue:7

    Topics: Animals; Glutamine; Glycolysis; Humans; Lipid Metabolism; Mitochondria; Neoplasms; RNA, Long Noncoding

2021
Glutamine metabolism: from proliferating cells to cardiomyocytes.
    Metabolism: clinical and experimental, 2021, Volume: 121

    Topics: Animals; Cell Differentiation; Cell Proliferation; Glutamine; Humans; Myoblasts, Cardiac; Myocytes, Cardiac; Neoplasms; Stem Cells; Tumor Microenvironment

2021
Enhancing the Efficacy of Glutamine Metabolism Inhibitors in Cancer Therapy.
    Trends in cancer, 2021, Volume: 7, Issue:8

    Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Benzeneacetamides; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Clinical Trials as Topic; Disease Models, Animal; Drug Resistance, Neoplasm; Glutaminase; Glutamine; Humans; Neoplasms; NF-E2-Related Factor 2; Oxidative Stress; Thiadiazoles; Tumor Escape; Tumor Microenvironment

2021
Targeting GLS1 to cancer therapy through glutamine metabolism.
    Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2021, Volume: 23, Issue:11

    Topics: Apoptosis; Benzophenanthridines; Cell Proliferation; Diazooxonorleucine; Disease Progression; Drug Resistance, Neoplasm; Genes, myc; Glutaminase; Glutamine; Humans; MicroRNAs; Neoplasm Proteins; Neoplasms; NF-kappa B; Oxidation-Reduction; Phosphates; Prognosis; Retinoblastoma Protein; Sulfides; Thiadiazoles

2021
Metabolomics-guided global pathway analysis reveals better insights into the metabolic alterations of breast cancer.
    Journal of pharmaceutical and biomedical analysis, 2021, Aug-05, Volume: 202

    Topics: Glutamine; Metabolic Networks and Pathways; Metabolome; Metabolomics; Neoplasms; Oxidation-Reduction

2021
Effect of glutamine metabolism on chemoresistance and its mechanism in tumors.
    Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2021, 02-25, Volume: 50, Issue:1

    Topics: Cell Line, Tumor; Drug Resistance, Neoplasm; Glutamine; Glycolysis; Humans; Neoplasms; Oxidative Phosphorylation; Tumor Microenvironment

2021
Glutamine Metabolism in Cancer: Understanding the Heterogeneity.
    Trends in cancer, 2017, Volume: 3, Issue:3

    Topics: Glutaminase; Glutamine; Humans; Molecular Targeted Therapy; Neoplasms

2017
Cancer cell metabolism: the essential role of the nonessential amino acid, glutamine.
    The EMBO journal, 2017, 05-15, Volume: 36, Issue:10

    Topics: Animals; Cell Proliferation; Glutamine; Humans; Neoplasms

2017
Therapeutic role of glutamine in management of radiation enteritis: a meta-analysis of 13 randomized controlled trials.
    Oncotarget, 2017, May-02, Volume: 8, Issue:18

    Topics: Case-Control Studies; Enteritis; Glutamine; Humans; Neoplasms; Odds Ratio; Publication Bias; Radiation Injuries; Radiotherapy; Randomized Controlled Trials as Topic; Severity of Illness Index; Treatment Outcome

2017
Hopefully devoted to Q: targeting glutamine addiction in cancer.
    British journal of cancer, 2017, May-23, Volume: 116, Issue:11

    Topics: Autophagy; Drug Discovery; Glutamine; Glycosylation; Humans; Metabolic Networks and Pathways; Neoplasms; TOR Serine-Threonine Kinases; Tumor Microenvironment

2017
Nutrient acquisition strategies of mammalian cells.
    Nature, 2017, 06-07, Volume: 546, Issue:7657

    Topics: Animals; Cell Proliferation; Cells; Endocytosis; Glucose; Glutamine; Intercellular Signaling Peptides and Proteins; Lysosomes; Neoplasms; Pinocytosis; Proteins; Tumor Microenvironment

2017
From Prokaryotes to Cancer: Glutamine Flux in Multicellular Units.
    Trends in endocrinology and metabolism: TEM, 2017, Volume: 28, Issue:9

    Topics: Animals; Biofilms; Biological Transport; Glutamine; Humans; Neoplasms; Prokaryotic Cells; Subcellular Fractions

2017
Drug-induced amino acid deprivation as strategy for cancer therapy.
    Journal of hematology & oncology, 2017, 07-27, Volume: 10, Issue:1

    Topics: Amino Acids; Antineoplastic Combined Chemotherapy Protocols; Arginine; Asparaginase; Glutamine; Humans; Neoplasms

2017
Targeting Metabolism for Cancer Therapy.
    Cell chemical biology, 2017, Sep-21, Volume: 24, Issue:9

    Topics: Antimetabolites; Argininosuccinate Synthase; Carbohydrate Metabolism; Fatty Acids; Glutamine; Glycolysis; Humans; Isocitrate Dehydrogenase; Metabolic Engineering; NAD; Neoplasms

2017
MYC and tumor metabolism: chicken and egg.
    The EMBO journal, 2017, 12-01, Volume: 36, Issue:23

    Topics: Animals; Apoptosis; Biogenic Polyamines; Forkhead Box Protein O1; Genes, myc; Glucose; Glutamine; Humans; Mechanistic Target of Rapamycin Complex 1; Metabolic Networks and Pathways; Neoplasms; Nucleotides; Proto-Oncogene Proteins c-myc; Stress, Physiological

2017
The diamond anniversary of tissue transglutaminase: a protein of many talents.
    Drug discovery today, 2018, Volume: 23, Issue:3

    Topics: Amines; Animals; Disease Progression; Glutamine; GTP-Binding Proteins; Humans; Neoplasms; Transglutaminases

2018
Impairing energy metabolism in solid tumors through agents targeting oncogenic signaling pathways.
    Biochemical pharmacology, 2018, Volume: 151

    Topics: Antineoplastic Agents; Carcinogens; Energy Metabolism; Glutamine; Glycolysis; Humans; Lipid Metabolism; Neoplasms; Signal Transduction

2018
CNF1-like deamidase domains: common Lego bricks among cancer-promoting immunomodulatory bacterial virulence factors.
    Pathogens and disease, 2018, 07-01, Volume: 76, Issue:5

    Topics: Amidohydrolases; Asparagine; Bacterial Toxins; Computational Biology; Enterobacteriaceae; Enterobacteriaceae Infections; Escherichia coli Proteins; Glutamine; Immunologic Factors; Neoplasms; rac1 GTP-Binding Protein; Virulence Factors

2018
Amino acid transporter SLC7A11/xCT at the crossroads of regulating redox homeostasis and nutrient dependency of cancer.
    Cancer communications (London, England), 2018, 04-25, Volume: 38, Issue:1

    Topics: Amino Acid Transport System y+; Antioxidants; Gene Expression Regulation, Neoplastic; Glucose; Glutamine; Homeostasis; Humans; Neoplasms; Nutrients; Oxidation-Reduction

2018
Cancer stem cell metabolism: target for cancer therapy.
    BMB reports, 2018, Volume: 51, Issue:7

    Topics: Glutamine; Glycolysis; Humans; Lipid Metabolism; Metabolic Networks and Pathways; Neoplasm Recurrence, Local; Neoplasms; Neoplastic Stem Cells; Oxidative Phosphorylation; Tumor Microenvironment

2018
Inhibition of Glycolysis and Glutaminolysis: An Emerging Drug Discovery Approach to Combat Cancer.
    Current topics in medicinal chemistry, 2018, Volume: 18, Issue:6

    Topics: Antineoplastic Agents; Drug Discovery; Glutamine; Glycolysis; Humans; Neoplasms

2018
Cancer in the crosshairs: targeting cancer metabolism with hyperpolarized carbon-13 MRI technology.
    NMR in biomedicine, 2019, Volume: 32, Issue:10

    Topics: Animals; Carbon Isotopes; Glutamine; Humans; Imaging, Three-Dimensional; Magnetic Resonance Imaging; Neoplasms

2019
Targeting cancer metabolism through synthetic lethality-based combinatorial treatment strategies.
    Current opinion in oncology, 2018, Volume: 30, Issue:5

    Topics: Amino Acid Transport System ASC; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials, Phase I as Topic; Glucose; Glucose Transport Proteins, Facilitative; Glutaminase; Glutamine; Humans; Lactic Acid; Minor Histocompatibility Antigens; Molecular Targeted Therapy; Monocarboxylic Acid Transporters; Neoplasms; Pyruvate Dehydrogenase Complex

2018
We're Not "DON" Yet: Optimal Dosing and Prodrug Delivery of
    Molecular cancer therapeutics, 2018, Volume: 17, Issue:9

    Topics: Animals; Antimetabolites, Antineoplastic; Diazooxonorleucine; Glutamine; Humans; Molecular Structure; Nausea; Neoplasms; Prodrugs; Vomiting

2018
Discovery and development of small molecule modulators targeting glutamine metabolism.
    European journal of medicinal chemistry, 2019, Feb-01, Volume: 163

    Topics: Animals; Antineoplastic Agents; Drug Discovery; Energy Metabolism; Glutamine; Humans; Neoplasms

2019
Glutamine as an Essential Amino Acid for KRas-Driven Cancer Cells.
    Trends in endocrinology and metabolism: TEM, 2019, Volume: 30, Issue:6

    Topics: Amino Acids, Essential; Animals; Glutamine; Humans; Neoplasms; Proto-Oncogene Proteins p21(ras); TOR Serine-Threonine Kinases

2019
Non-canonical roles for metabolic enzymes and intermediates in malignant progression and metastasis.
    Clinical & experimental metastasis, 2019, Volume: 36, Issue:3

    Topics: ATP Citrate (pro-S)-Lyase; Disease Progression; Energy Metabolism; Fatty Acids; Glucose; Glucose-6-Phosphate Isomerase; Glutaminase; Glutamine; Humans; Isocitrate Dehydrogenase; Neoplasm Metastasis; Neoplasms

2019
Therapeutic targeting of glutaminolysis as an essential strategy to combat cancer.
    Seminars in cell & developmental biology, 2020, Volume: 98

    Topics: Antineoplastic Agents; Cell Proliferation; Cellular Reprogramming; Enzyme Inhibitors; Glutaminase; Glutamine; Humans; Neoplasms

2020
Molecular mechanisms of ferroptosis and its role in cancer therapy.
    Journal of cellular and molecular medicine, 2019, Volume: 23, Issue:8

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cysteine; Endoplasmic Reticulum Stress; Fatty Acids, Unsaturated; Ferroptosis; Glutamine; Humans; Iron; Lipid Peroxidation; Lysosomes; Mitochondria; Neoplasms; Phospholipid Hydroperoxide Glutathione Peroxidase; Signal Transduction

2019
Systematic review of natural and miscellaneous agents for the management of oral mucositis in cancer patients and clinical practice guidelines-part 1: vitamins, minerals, and nutritional supplements.
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2019, Volume: 27, Issue:10

    Topics: Dietary Supplements; Glutamine; Head and Neck Neoplasms; Humans; Minerals; Mucositis; Neoplasms; Stomatitis; Vitamins

2019
Systematic review of agents for the management of cancer treatment-related gastrointestinal mucositis and clinical practice guidelines.
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2019, Volume: 27, Issue:10

    Topics: Butyric Acid; Chemoradiotherapy; Fibroblast Growth Factor 7; Glutamine; Humans; Hyperbaric Oxygenation; Mucositis; Neoplasms; Practice Guidelines as Topic; Proctitis; Stomatitis

2019
Integrating dietary supplements into cancer care.
    Integrative cancer therapies, 2013, Volume: 12, Issue:5

    Topics: Camellia sinensis; Curcumin; Dietary Supplements; Fish Oils; Glutamine; Grifola; Humans; Integrative Medicine; Neoplasms; Probiotics; Vitamin D

2013
miRNAs link metabolic reprogramming to oncogenesis.
    Trends in endocrinology and metabolism: TEM, 2013, Volume: 24, Issue:7

    Topics: Animals; Carcinogenesis; Cell Proliferation; Citric Acid Cycle; Energy Metabolism; Glutamine; Glycolysis; Humans; Lipogenesis; MicroRNAs; Neoplasm Metastasis; Neoplasms; Signal Transduction

2013
Stalling the engine of resistance: targeting cancer metabolism to overcome therapeutic resistance.
    Cancer research, 2013, May-01, Volume: 73, Issue:9

    Topics: Absorption; Animals; Cell Enlargement; Cell Proliferation; Citric Acid Cycle; Drug Resistance, Neoplasm; Fatty Acids; Glucose; Glutamine; Glycolysis; Humans; Lactates; Neoplasms; Signal Transduction; Treatment Outcome

2013
A systems biology road map for the discovery of drugs targeting cancer cell metabolism.
    Current pharmaceutical design, 2014, Volume: 20, Issue:15

    Topics: Drug Discovery; Drug Resistance, Neoplasm; Genomic Instability; Glucose; Glutamine; Humans; Neoplasms; Signal Transduction; Systems Biology

2014
Glutamine, glucose and other fuels for cancer.
    Current pharmaceutical design, 2014, Volume: 20, Issue:15

    Topics: Ammonia; Animals; Citric Acid Cycle; Glucose; Glutaminase; Glutamine; Glycolysis; Humans; Neoplasms; Oxidative Phosphorylation; Retinoblastoma Protein

2014
Glutamine and cancer: cell biology, physiology, and clinical opportunities.
    The Journal of clinical investigation, 2013, Volume: 123, Issue:9

    Topics: Animals; Biomarkers, Tumor; Energy Metabolism; Glutamine; Humans; Metabolic Networks and Pathways; Molecular Targeted Therapy; Neoplasms; Organ Specificity

2013
Coordination of nutrient availability and utilization by MAX- and MLX-centered transcription networks.
    Cold Spring Harbor perspectives in medicine, 2013, Sep-01, Volume: 3, Issue:9

    Topics: Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Basic-Leucine Zipper Transcription Factors; Carrier Proteins; Food; G1 Phase; Gene Regulatory Networks; Genes, myc; Glucose; Glutamine; Humans; Neoplasms; Tumor Suppressor Proteins

2013
Therapeutic strategies impacting cancer cell glutamine metabolism.
    Future medicinal chemistry, 2013, Volume: 5, Issue:14

    Topics: Animals; Antineoplastic Agents; Cell Transformation, Neoplastic; Glutaminase; Glutamine; Humans; Models, Molecular; Molecular Targeted Therapy; Neoplasms; Signal Transduction

2013
How does the metabolism of tumour cells differ from that of normal cells.
    Bioscience reports, 2013, Nov-15, Volume: 33, Issue:6

    Topics: Animals; Antineoplastic Agents; Energy Metabolism; Glutamine; Glycolysis; Humans; Mitochondria; Molecular Targeted Therapy; Neoplasms

2013
Exploiting the bad eating habits of Ras-driven cancers.
    Genes & development, 2013, Oct-01, Volume: 27, Issue:19

    Topics: Animals; Autophagy; Glucose; Glutamine; Humans; Lipid Metabolism; Metabolic Networks and Pathways; Neoplasms; Proteins; ras Proteins

2013
Glutaminase regulation in cancer cells: a druggable chain of events.
    Drug discovery today, 2014, Volume: 19, Issue:4

    Topics: Animals; Antineoplastic Agents; Glutaminase; Glutamine; Humans; Neoplasms

2014
Altered glutamine metabolism and therapeutic opportunities for lung cancer.
    Clinical lung cancer, 2014, Volume: 15, Issue:1

    Topics: Animals; Antineoplastic Agents; Energy Metabolism; Glutamine; Glycolysis; Humans; Neoplasms

2014
Targeting metabolic changes in cancer: novel therapeutic approaches.
    Annual review of medicine, 2014, Volume: 65

    Topics: Antimetabolites, Antineoplastic; Biomarkers, Tumor; DNA-Binding Proteins; Fatty Acids; Glutamine; Humans; Isocitrate Dehydrogenase; Methotrexate; NAD; Neoplasms; Phosphopyruvate Hydratase; Signal Transduction; Tumor Suppressor Proteins

2014
Who controls the ATP supply in cancer cells? Biochemistry lessons to understand cancer energy metabolism.
    The international journal of biochemistry & cell biology, 2014, Volume: 50

    Topics: Adenosine Triphosphate; Animals; Biological Transport; Energy Metabolism; Glutamine; Humans; Neoplasms; Oxidative Phosphorylation

2014
Autophagy and cancer metabolism.
    Methods in enzymology, 2014, Volume: 542

    Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Amino Acids; Animals; Apoptosis Regulatory Proteins; Autophagy; Autophagy-Related Proteins; Beclin-1; Cell Hypoxia; Cell Survival; Class III Phosphatidylinositol 3-Kinases; Glucose; Glutamine; Glycolysis; Humans; Membrane Proteins; Mitochondria; Neoplasms; Reactive Oxygen Species; Sequestosome-1 Protein; Stromal Cells

2014
Impact of MYC in regulation of tumor cell metabolism.
    Biochimica et biophysica acta, 2015, Volume: 1849, Issue:5

    Topics: Cell Proliferation; Genomic Instability; Glutamine; Glycolysis; Humans; Lipid Metabolism; Neoplasms; Proto-Oncogene Proteins c-myc; Tumor Microenvironment

2015
Follow the ATP: tumor energy production: a perspective.
    Anti-cancer agents in medicinal chemistry, 2014, Volume: 14, Issue:9

    Topics: Adenosine Triphosphate; Autophagy; Carrier Proteins; Energy Metabolism; Glucose; Glucose Transporter Type 1; Glutamine; Hexokinase; Humans; Kidney Neoplasms; Membrane Proteins; NAD; Neoplasms; Pentose Phosphate Pathway; Thyroid Hormone-Binding Proteins; Thyroid Hormones

2014
Proline metabolism and cancer: emerging links to glutamine and collagen.
    Current opinion in clinical nutrition and metabolic care, 2015, Volume: 18, Issue:1

    Topics: Animals; Collagen; Glutamine; Humans; Neoplasms; Proline; Proto-Oncogene Mas

2015
Redox control of glutamine utilization in cancer.
    Cell death & disease, 2014, Dec-04, Volume: 5

    Topics: Amino Acids; Antineoplastic Agents; Glutamine; Glycolysis; Humans; Lipids; Mitochondria; Mitochondrial Proteins; NAD; NADP; NADP Transhydrogenase, AB-Specific; Neoplasms; Oxidation-Reduction; Pentose Phosphate Pathway; Reactive Oxygen Species

2014
Mitochondrial sirtuins and their relationships with metabolic disease and cancer.
    Antioxidants & redox signaling, 2015, Apr-20, Volume: 22, Issue:12

    Topics: Aging; Animals; Carcinogenesis; Glutamine; Homeostasis; Humans; Metabolic Diseases; Mitochondrial Proteins; Neoplasms; Sirtuins

2015
Famine versus feast: understanding the metabolism of tumors in vivo.
    Trends in biochemical sciences, 2015, Volume: 40, Issue:3

    Topics: Animals; Energy Metabolism; Food; Glucose; Glutamine; Humans; Neoplasms; Starvation

2015
Amino Acid transporters in cancer and their relevance to "glutamine addiction": novel targets for the design of a new class of anticancer drugs.
    Cancer research, 2015, May-01, Volume: 75, Issue:9

    Topics: Amino Acid Transport Systems; Animals; Antineoplastic Agents; Glutamine; Humans; Molecular Targeted Therapy; Neoplasms

2015
[Isotopic tracing technique in quantitative analysis of metabolic reprogramming in tumor cells].
    Se pu = Chinese journal of chromatography, 2015, Volume: 33, Issue:2

    Topics: Carbon Isotopes; Cell Line, Tumor; Citric Acid Cycle; Glutamine; Humans; Isotope Labeling; Mass Spectrometry; Neoplasms; Pentose Phosphate Pathway; Serine

2015
Metabolic and mind shifts: from glucose to glutamine and acetate addictions in cancer.
    Current opinion in clinical nutrition and metabolic care, 2015, Volume: 18, Issue:4

    Topics: Acetates; Acetyl Coenzyme A; Cell Line, Tumor; Citrates; Citric Acid Cycle; Glucose; Glutamine; Humans; Hypoxia; Ketoglutaric Acids; Lipogenesis; Neoplasms

2015
Glutaminolysis and autophagy in cancer.
    Autophagy, 2015, Volume: 11, Issue:8

    Topics: Animals; Autophagy; Cell Proliferation; Cell Transformation, Neoplastic; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Glutamine; Humans; Ketoglutaric Acids; Mechanistic Target of Rapamycin Complex 1; Multiprotein Complexes; Neoplasm Recurrence, Local; Neoplasms; Reactive Oxygen Species; Signal Transduction; TOR Serine-Threonine Kinases

2015
The role of mammalian sirtuins in cancer metabolism.
    Seminars in cell & developmental biology, 2015, Volume: 43

    Topics: Aging; Animals; Cell Proliferation; Cell Transformation, Neoplastic; Glutamine; Glycolysis; Humans; Mice; Mitochondria; Neoplasms; Signal Transduction; Sirtuins

2015
ω-Amidase: an underappreciated, but important enzyme in L-glutamine and L-asparagine metabolism; relevance to sulfur and nitrogen metabolism, tumor biology and hyperammonemic diseases.
    Amino acids, 2016, Volume: 48, Issue:1

    Topics: Amidohydrolases; Animals; Asparagine; Glutamine; Humans; Hyperammonemia; Neoplasms; Nitrogen; Sulfur

2016
Amino acid management in cancer.
    Seminars in cell & developmental biology, 2015, Volume: 43

    Topics: Citric Acid Cycle; Glutamine; Humans; Neoplasms; Protein Biosynthesis; Serine; Signal Transduction; TOR Serine-Threonine Kinases

2015
Targeting Glutamine Induces Apoptosis: A Cancer Therapy Approach.
    International journal of molecular sciences, 2015, Sep-22, Volume: 16, Issue:9

    Topics: Animals; Apoptosis; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Glutaminase; Glutamine; Humans; Hypoxia-Inducible Factor 1; Neoplasms; Proto-Oncogene Proteins c-myc; ras Proteins; Tumor Suppressor Protein p53

2015
The greedy nature of mutant RAS: a boon for drug discovery targeting cancer metabolism?
    Acta biochimica et biophysica Sinica, 2016, Volume: 48, Issue:1

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Drug Discovery; Gene Expression Regulation, Neoplastic; Genes, ras; Glutamine; Glycolysis; Humans; Mice; Molecular Targeted Therapy; Mutation; Neoplasm Transplantation; Neoplasms; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; ras Proteins; RNA Interference; Signal Transduction

2016
Oral Glutamine in Preventing Treatment-Related Mucositis in Adult Patients With Cancer: A Systematic Review.
    Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition, 2016, Volume: 31, Issue:2

    Topics: Administration, Oral; Databases, Factual; Glutamine; Humans; Mucositis; Neoplasms; Randomized Controlled Trials as Topic; Risk Factors

2016
Key Roles of Glutamine Pathways in Reprogramming the Cancer Metabolism.
    Oxidative medicine and cellular longevity, 2015, Volume: 2015

    Topics: Glioblastoma; Gluconeogenesis; Glutamine; Glutathione; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Ketone Oxidoreductases; Neoplasms; Reactive Oxygen Species

2015
Glutaminolysis as a target for cancer therapy.
    Oncogene, 2016, 07-14, Volume: 35, Issue:28

    Topics: Antineoplastic Agents; Cell Proliferation; Cell Survival; Glutamine; Humans; Metabolic Networks and Pathways; Molecular Structure; Molecular Targeted Therapy; Neoplasms; Small Molecule Libraries

2016
Prophylaxis for mucositis induced by ambulatory chemotherapy: systematic review.
    Journal of advanced nursing, 2016, Volume: 72, Issue:4

    Topics: Allopurinol; Ambulatory Care; Anti-Inflammatory Agents; Antineoplastic Agents; Chlorhexidine; Controlled Clinical Trials as Topic; Cryotherapy; Fibroblast Growth Factor 7; Glutamine; Humans; Neoplasms; Oral Hygiene; Stomatitis

2016
Glutamine at focus: versatile roles in cancer.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2016, Volume: 37, Issue:2

    Topics: Animals; Energy Metabolism; Glutamine; Humans; Neoplasms; Signal Transduction

2016
Glutamine transporters in mammalian cells and their functions in physiology and cancer.
    Biochimica et biophysica acta, 2016, Volume: 1863, Issue:10

    Topics: Animals; Biological Transport, Active; Carrier Proteins; Cell Membrane; Glutamine; Humans; Mammals; Metabolism, Inborn Errors; Mice; Mice, Knockout; Molecular Targeted Therapy; Multigene Family; Neoplasm Proteins; Neoplasms; Substrate Specificity

2016
Prevention and treatment of cancers by immune modulating nutrients.
    Molecular nutrition & food research, 2016, Volume: 60, Issue:6

    Topics: Animals; Arginine; Catechin; Cell Line, Tumor; Diet; Disease Models, Animal; Fatty Acids, Unsaturated; Glutamine; Humans; Isothiocyanates; Lignans; Meta-Analysis as Topic; Micronutrients; Neoplasms; Observational Studies as Topic; Phytochemicals; Polyphenols; Randomized Controlled Trials as Topic; Stilbenes

2016
Cancer metabolism: a therapeutic perspective.
    Nature reviews. Clinical oncology, 2017, Volume: 14, Issue:1

    Topics: Acetyl Coenzyme A; Adaptation, Physiological; Amino Acids; Antineoplastic Agents; Antioxidants; Autophagy; Blood Glucose; Energy Metabolism; Epigenomics; Fatty Acids; Genetic Heterogeneity; Glutamic Acid; Glutamine; Humans; Ketone Bodies; Lactic Acid; Lipids; Mitochondria; Mitochondrial Ribosomes; Neoplasms; Nucleic Acids; Oxidative Stress; Pyruvic Acid; TOR Serine-Threonine Kinases; Transcription Factors; Tumor Microenvironment

2017
From Krebs to clinic: glutamine metabolism to cancer therapy.
    Nature reviews. Cancer, 2016, Volume: 16, Issue:10

    Topics: Adenosine Triphosphate; Citric Acid Cycle; Glutamine; Glutarates; Humans; Neoplasms

2016
Long non-coding RNAs in cancer metabolism.
    BioEssays : news and reviews in molecular, cellular and developmental biology, 2016, Volume: 38, Issue:10

    Topics: Animals; Gene Expression Regulation, Neoplastic; Genes, Neoplasm; Glucose; Glutamine; Humans; Neoplasms; RNA, Long Noncoding; Signal Transduction

2016
[Metabolome analysis of solid tumors].
    Der Pathologe, 2016, Volume: 37, Issue:Suppl 2

    Topics: 4-Aminobutyrate Transaminase; beta-Alanine; Biomarkers, Tumor; Breast; Breast Neoplasms; Colonic Neoplasms; Female; Gas Chromatography-Mass Spectrometry; Glutamic Acid; Glutaminase; Glutamine; Humans; Metabolome; Neoplasms; Neoplasms, Hormone-Dependent; Ovarian Neoplasms; Ovary

2016
Regional tumour glutamine supply affects chromatin and cell identity.
    Nature cell biology, 2016, Sep-28, Volume: 18, Issue:10

    Topics: Animals; Cell Differentiation; Chromatin; Glutamine; Humans; Ketoglutaric Acids; Neoplasms; Tumor Microenvironment

2016
Nutrients and the microenvironment to feed a T cell army.
    Seminars in immunology, 2016, Volume: 28, Issue:5

    Topics: Adaptation, Physiological; Animals; Biological Clocks; Cellular Microenvironment; Energy Metabolism; Epigenesis, Genetic; Gene Expression Regulation; Glucose; Glutamine; Humans; Lymphocytes, Tumor-Infiltrating; Neoplasms; Signal Transduction; T-Lymphocyte Subsets

2016
Caveolin-1 in the regulation of cell metabolism: a cancer perspective.
    Molecular cancer, 2016, 11-16, Volume: 15, Issue:1

    Topics: Animals; Autophagy; Caveolin 1; Energy Metabolism; Fatty Acids; Gene Expression Regulation, Neoplastic; Glutamine; Glycolysis; Humans; Insulin Resistance; Metabolic Networks and Pathways; Mitochondria; Neoplasms; Obesity

2016
A Time for MYC: Metabolism and Therapy.
    Cold Spring Harbor symposia on quantitative biology, 2016, Volume: 81

    Topics: Animals; Cell Proliferation; Glucose; Glutamine; Humans; Neoplasms; Promoter Regions, Genetic; Proto-Oncogene Mas; Proto-Oncogene Proteins c-myc

2016
Metabolic Imaging of Glutamine in Cancer.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2017, Volume: 58, Issue:4

    Topics: Glutamine; Humans; Molecular Imaging; Neoplasms; Positron-Emission Tomography

2017
Glutaminolysis: A Hallmark of Cancer Metabolism.
    Annual review of biomedical engineering, 2017, 06-21, Volume: 19

    Topics: Animals; Biomarkers, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Glutamine; Humans; Mitochondria; Models, Biological; Neoplasms; Signal Transduction

2017
Oral glutamine for the prevention of chemotherapy-induced peripheral neuropathy.
    The Annals of pharmacotherapy, 2008, Volume: 42, Issue:10

    Topics: Administration, Oral; Antineoplastic Agents; Clinical Trials as Topic; Dose-Response Relationship, Drug; Glutamine; Humans; Neoplasms; Organoplatinum Compounds; Peripheral Nervous System Diseases; Taxoids; Vinca Alkaloids

2008
The molecular determinants of de novo nucleotide biosynthesis in cancer cells.
    Current opinion in genetics & development, 2009, Volume: 19, Issue:1

    Topics: Animals; Cell Line, Tumor; Cell Transformation, Neoplastic; Glucose; Glutamine; Glycolysis; Humans; Models, Biological; Neoplasms; Pentose Phosphate Pathway; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-myc; Ribosemonophosphates

2009
Dichotomic actions of glutamine in host versus tumour: an emerging concept.
    Current opinion in clinical nutrition and metabolic care, 2009, Volume: 12, Issue:4

    Topics: Animals; Antineoplastic Agents; Glutamine; Glutathione; Humans; Neoplasms; Radiation Injuries

2009
Hot topics in parenteral nutrition. A review of the use of glutamine supplementation in the nutritional support of patients undergoing bone-marrow transplantation and traditional cancer therapy.
    The Proceedings of the Nutrition Society, 2009, Volume: 68, Issue:3

    Topics: Administration, Oral; Animals; Bone Marrow Transplantation; Clinical Trials as Topic; Combined Modality Therapy; Dietary Supplements; Glutamine; Humans; Mucositis; Neoplasms; Parenteral Nutrition

2009
Glutamine homeostasis and mitochondrial dynamics.
    The international journal of biochemistry & cell biology, 2009, Volume: 41, Issue:10

    Topics: Animals; Brain; Glutaminase; Glutamine; Homeostasis; Humans; Mitochondria; Neoplasms; Oxidation-Reduction; Oxidative Stress

2009
Mitochondrial metabolism and cancer.
    Annals of the New York Academy of Sciences, 2009, Volume: 1177

    Topics: Adenosine Triphosphate; Animals; Citric Acid Cycle; Glutamine; Glycolysis; Humans; Mitochondria; Models, Biological; NADP; Neoplasms; Reactive Oxygen Species

2009
MYC-induced cancer cell energy metabolism and therapeutic opportunities.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2009, Nov-01, Volume: 15, Issue:21

    Topics: Cell Transformation, Neoplastic; Energy Metabolism; Gene Expression Regulation, Neoplastic; Genes, myc; Glucose; Glutamine; Glycolysis; Humans; Hypoxia-Inducible Factor 1; Neoplasms; Oxidative Phosphorylation; Proto-Oncogene Proteins c-myc; Signal Transduction

2009
Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer.
    Oncogene, 2010, Jan-21, Volume: 29, Issue:3

    Topics: Cell Proliferation; Cell Survival; Citric Acid Cycle; Energy Metabolism; Glucose; Glutamine; Humans; Models, Biological; Neoplasms; Signal Transduction

2010
Glutamine as indispensable nutrient in oncology: experimental and clinical evidence.
    European journal of nutrition, 2010, Volume: 49, Issue:4

    Topics: Administration, Oral; Antineoplastic Agents; Cachexia; Glutamine; Glutathione; Humans; Infusions, Intravenous; Neoplasms; Randomized Controlled Trials as Topic

2010
L-glutamine use in the treatment and prevention of mucositis and cachexia: a naturopathic perspective.
    Integrative cancer therapies, 2009, Volume: 8, Issue:4

    Topics: Administration, Oral; Amino Acids; Animals; Antineoplastic Agents; Cachexia; Glutamine; Humans; Mucositis; Naturopathy; Neoplasms; Radiotherapy, Adjuvant; Stomatitis

2009
Rethinking the Warburg effect with Myc micromanaging glutamine metabolism.
    Cancer research, 2010, Feb-01, Volume: 70, Issue:3

    Topics: Animals; Citric Acid Cycle; Gene Expression Regulation, Neoplastic; Glucose; Glutamine; Humans; MicroRNAs; Mitochondria; Models, Biological; Neoplasms; Proto-Oncogene Proteins c-myc

2010
Pyruvate kinase type M2: a key regulator of the metabolic budget system in tumor cells.
    The international journal of biochemistry & cell biology, 2011, Volume: 43, Issue:7

    Topics: Animals; Biomarkers, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Glucose; Glutamine; Glycolysis; Humans; Isoenzymes; Metabolic Networks and Pathways; Mice; Models, Biological; Neoplasm Proteins; Neoplasms; Octamer Transcription Factor-3; Oncogene Proteins; Protein Interaction Mapping; Protein Serine-Threonine Kinases; Pyruvate Kinase; Rats; Tumor Suppressor Proteins

2011
Waves of gene regulation suppress and then restore oxidative phosphorylation in cancer cells.
    The international journal of biochemistry & cell biology, 2011, Volume: 43, Issue:7

    Topics: Adaptation, Biological; Cell Hypoxia; Cell Proliferation; Energy Metabolism; Gene Expression Regulation; Genes, myc; Glucose; Glutamine; Humans; Lactic Acid; Metabolic Networks and Pathways; Mitochondria; Neoplasms; Oxidative Phosphorylation; Phosphatidylinositol 3-Kinase; Protein Serine-Threonine Kinases; Pyruvic Acid

2011
Ammonia: a diffusible factor released by proliferating cells that induces autophagy.
    Science signaling, 2010, Jun-01, Volume: 3, Issue:124

    Topics: Ammonia; Animals; Autophagy; Cell Proliferation; Glutamine; Humans; Hydrolases; Lysosomes; Neoplasms

2010
Glutamine addiction: a new therapeutic target in cancer.
    Trends in biochemical sciences, 2010, Volume: 35, Issue:8

    Topics: Animals; Glutamine; Humans; Mitochondria; Molecular Targeted Therapy; NADP; Neoplasms; Nucleotides; Protein Biosynthesis; TOR Serine-Threonine Kinases

2010
Balancing biosynthesis and bioenergetics: metabolic programs in oncogenesis.
    Endocrine-related cancer, 2010, Volume: 17, Issue:4

    Topics: Cell Transformation, Neoplastic; Energy Metabolism; Fatty Acids; Glutamine; Glycolysis; Humans; Neoplasms; Signal Transduction

2010
Hypoxia-induced metabolic shifts in cancer cells: moving beyond the Warburg effect.
    The international journal of biochemistry & cell biology, 2011, Volume: 43, Issue:7

    Topics: Animals; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Enzyme Inhibitors; Fatty Acids; Glutamine; Glycolysis; Humans; Hypoxia-Inducible Factor 1; Lipid Metabolism; Magnetic Resonance Spectroscopy; Mass Spectrometry; Metabolomics; Mice; Mitochondria; Neoplasms; Oxidative Phosphorylation

2011
Survival of the fittest: metabolic adaptations in cancer.
    Current opinion in genetics & development, 2011, Volume: 21, Issue:1

    Topics: Adaptation, Biological; Animals; Cell Proliferation; Glucose; Glutamine; Humans; Mitochondria; Neoplasms

2011
The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes.
    Science (New York, N.Y.), 2010, Dec-03, Volume: 330, Issue:6009

    Topics: Adenosine Triphosphate; Cell Division; Citric Acid Cycle; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Glucose; Glutamine; Glycolysis; Humans; NADP; Neoplasms; Oncogenes; Pentose Phosphate Pathway; Signal Transduction

2010
Regulation of protein metabolism by glutamine: implications for nutrition and health.
    Frontiers in bioscience (Landmark edition), 2011, 01-01, Volume: 16, Issue:2

    Topics: Animals; Burns; Critical Illness; Dietary Supplements; Glutamine; Humans; Infant, Newborn; Infant, Very Low Birth Weight; Malnutrition; Muscle, Skeletal; Muscular Dystrophy, Duchenne; Neoplasms; Nutritional Sciences; Proteins; Rats; Sepsis

2011
Nutrition modulation of gastrointestinal toxicity related to cancer chemotherapy: from preclinical findings to clinical strategy.
    JPEN. Journal of parenteral and enteral nutrition, 2011, Volume: 35, Issue:1

    Topics: Antineoplastic Agents; Cachexia; Fatty Acids, Omega-3; Gastrointestinal Diseases; Glutamine; Humans; Neoplasms; Nutritional Physiological Phenomena; Probiotics; Randomized Controlled Trials as Topic

2011
Stromal-epithelial metabolic coupling in cancer: integrating autophagy and metabolism in the tumor microenvironment.
    The international journal of biochemistry & cell biology, 2011, Volume: 43, Issue:7

    Topics: Animals; Autophagy; Biomarkers, Tumor; Caveolin 1; Cell Hypoxia; Cell Line, Tumor; Coculture Techniques; Female; Fibroblasts; Glutamine; Glycolysis; Humans; Mice; Mitochondria; Models, Biological; Neoplasms; Oxidative Stress; Reactive Oxygen Species; Stromal Cells; Tumor Microenvironment

2011
Glutamine: pleiotropic roles in tumor growth and stress resistance.
    Journal of molecular medicine (Berlin, Germany), 2011, Volume: 89, Issue:3

    Topics: Autophagy; Glutamine; Models, Biological; Neoplasms; Oxidative Stress

2011
Therapeutic targeting of cancer cell metabolism.
    Journal of molecular medicine (Berlin, Germany), 2011, Volume: 89, Issue:3

    Topics: Animals; Glutamine; Glycolysis; Humans; Models, Biological; Neoplasms

2011
Nutritional intervention for improving treatment tolerance in cancer patients.
    Current opinion in oncology, 2011, Volume: 23, Issue:4

    Topics: Amino Acids; Arginine; Cachexia; Dietary Supplements; Fatty Acids, Omega-3; Feeding Behavior; Glutamine; Humans; Malnutrition; Neoplasms; Nutritional Status; Nutritional Support; Weight Loss

2011
Viral effects on metabolism: changes in glucose and glutamine utilization during human cytomegalovirus infection.
    Trends in microbiology, 2011, Volume: 19, Issue:7

    Topics: Carbon; Cells, Cultured; Citric Acid; Citric Acid Cycle; Cytomegalovirus; Energy Metabolism; Fatty Acids; Glucose; Glutamine; Glycolysis; Host-Pathogen Interactions; Humans; Ketoglutaric Acids; Mitochondria; Mitochondrial Membranes; Neoplasms; Phosphorylation

2011
Dynamic nuclear polarization in metabolic imaging of metastasis: common sense, hypersense and compressed sensing.
    Cancer biomarkers : section A of Disease markers, 2010, Volume: 7, Issue:4

    Topics: Bicarbonates; Diagnostic Imaging; Glutamine; Humans; Magnetic Resonance Spectroscopy; Neoplasm Metastasis; Neoplasms; Pyruvic Acid

2010
An extended Myc network contributes to glucose homeostasis in cancer and diabetes.
    Frontiers in bioscience (Landmark edition), 2011, 06-01, Volume: 16, Issue:6

    Topics: Animals; Arrestins; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Carrier Proteins; Cell Proliferation; Diabetes Mellitus; Glucose; Glutamine; Homeostasis; Humans; Insulin Resistance; Metabolic Networks and Pathways; Mice; Models, Biological; Neoplasms; Nuclear Proteins; Proto-Oncogene Proteins c-myc; Thioredoxins; Transcription Factors

2011
The autophagy conundrum in cancer: influence of tumorigenic metabolic reprogramming.
    Oncogene, 2011, Nov-24, Volume: 30, Issue:47

    Topics: Animals; Autophagy; Cell Hypoxia; Glutamine; Glycolysis; Humans; Lipogenesis; Neoplasms; Reactive Oxygen Species; TOR Serine-Threonine Kinases; Tumor Suppressor Protein p53

2011
Role of glutamine in cancer: therapeutic and imaging implications.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2011, Volume: 52, Issue:7

    Topics: Animals; Glutamine; Humans; Molecular Imaging; Neoplasms

2011
The relationships of nutrients, routes of delivery, and immunocompetence.
    The Surgical clinics of North America, 2011, Volume: 91, Issue:4

    Topics: Arginine; Dietary Supplements; Enteral Nutrition; Fatty Acids, Omega-3; Fatty Acids, Omega-6; Glutamine; Humans; Immune System; Immune Tolerance; Immunocompetence; Malnutrition; Neoplasms; Nutritional Support; Parenteral Nutrition; Parenteral Nutrition, Total; Perioperative Care; Surgical Procedures, Operative; Wounds and Injuries

2011
Metabolic alterations in cancer cells and therapeutic implications.
    Chinese journal of cancer, 2011, Volume: 30, Issue:8

    Topics: Antineoplastic Agents; Drug Resistance, Neoplasm; Genes, Tumor Suppressor; Glutamine; Glycolysis; Humans; Mitochondria; Mutation; Neoplasms; Neoplastic Stem Cells; Oncogenes; Oxidative Phosphorylation

2011
Expanding targets for a metabolic therapy of cancer: L-asparaginase.
    Recent patents on anti-cancer drug discovery, 2012, Volume: 7, Issue:1

    Topics: Animals; Antineoplastic Agents; Asparaginase; Asparagine; Drug Delivery Systems; Glutaminase; Glutamine; Humans; Metabolic Networks and Pathways; Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2012
Targeting cancer metabolism: a therapeutic window opens.
    Nature reviews. Drug discovery, 2011, Aug-31, Volume: 10, Issue:9

    Topics: Animals; Antineoplastic Agents; Drug Delivery Systems; Energy Metabolism; Enzymes; Glucose; Glutamine; Humans; Lactates; NAD; Neoplasms; Signal Transduction

2011
[Treatment and prevention of cancer treatment related oral mucositis].
    Revista medica de Chile, 2011, Volume: 139, Issue:3

    Topics: Antineoplastic Agents; Cryotherapy; Glutamine; Humans; Low-Level Light Therapy; Neoplasms; Oral Hygiene; Practice Guidelines as Topic; Severity of Illness Index; Stomatitis

2011
Therapeutic targeting of Myc-reprogrammed cancer cell metabolism.
    Cold Spring Harbor symposia on quantitative biology, 2011, Volume: 76

    Topics: Glucose; Glutamine; Humans; Molecular Targeted Therapy; Neoplasms; Proto-Oncogene Proteins c-myc; Ribosomes

2011
Tumor cell metabolism: an integral view.
    Cancer biology & therapy, 2011, Dec-01, Volume: 12, Issue:11

    Topics: Acidosis; Aerobiosis; Animals; Cell Hypoxia; Cell Proliferation; Glutamine; Glycolysis; Humans; Lipid Metabolism; Neoplasms; Nucleotides

2011
Alterations of metabolic genes and metabolites in cancer.
    Seminars in cell & developmental biology, 2012, Volume: 23, Issue:4

    Topics: Animals; Cell Transformation, Neoplastic; Energy Metabolism; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Genes, Neoplasm; Glucose; Glutamine; Humans; Metabolic Networks and Pathways; Metabolome; Mutation; Neoplasms

2012
Carbon source metabolism and its regulation in cancer cells.
    Critical reviews in eukaryotic gene expression, 2012, Volume: 22, Issue:1

    Topics: Adenosine Triphosphate; Biomarkers, Tumor; Carbon; Cell Proliferation; Energy Metabolism; Gene Expression Regulation; Glucose; Glutamine; Humans; Hypoxia-Inducible Factor 1; MAP Kinase Signaling System; Neoplasms; Nitrogen; Oxygen; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-myc; Signal Transduction

2012
Metabolic reprogramming in cancer: unraveling the role of glutamine in tumorigenesis.
    Seminars in cell & developmental biology, 2012, Volume: 23, Issue:4

    Topics: Animals; Cell Proliferation; Cell Transformation, Neoplastic; Energy Metabolism; Glucose; Glutamine; Humans; Mutation; Neoplasms; Oxidation-Reduction; Proto-Oncogene Proteins; Signal Transduction

2012
The Xenopus oocyte: a model for studying the metabolic regulation of cancer cell death.
    Seminars in cell & developmental biology, 2012, Volume: 23, Issue:4

    Topics: Animals; Apoptosis; Energy Metabolism; Glutamine; Humans; Lipid Metabolism; Metabolic Networks and Pathways; Neoplasms; Oocytes; Xenopus laevis

2012
Normal and cancer cell metabolism: lymphocytes and lymphoma.
    The FEBS journal, 2012, Volume: 279, Issue:15

    Topics: Animals; Genes, myc; Glucose; Glutamine; Humans; Lymphocyte Activation; Lymphoma; Mutation; Neoplasms; Proto-Oncogene Proteins c-akt; Signal Transduction; T-Lymphocytes

2012
Glutamine for chemotherapy induced diarrhea: a meta-analysis.
    Asia Pacific journal of clinical nutrition, 2012, Volume: 21, Issue:3

    Topics: Antidiarrheals; Antineoplastic Agents; Diarrhea; Enteral Nutrition; Glutamine; Humans; Neoplasms; Parenteral Nutrition; Randomized Controlled Trials as Topic

2012
Dysregulation of glucose transport, glycolysis, TCA cycle and glutaminolysis by oncogenes and tumor suppressors in cancer cells.
    Biochimica et biophysica acta, 2012, Volume: 1826, Issue:2

    Topics: Animals; Biological Transport; Citric Acid Cycle; Glucose; Glutamine; Glycolysis; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Neoplasms; Oncogenes; Tumor Suppressor Protein p53; Tumor Suppressor Proteins

2012
ATP-citrate lyase: a key player in cancer metabolism.
    Cancer research, 2012, Aug-01, Volume: 72, Issue:15

    Topics: Animals; ATP Citrate (pro-S)-Lyase; Fatty Acids; Glucose; Glutamine; Humans; Metabolic Networks and Pathways; Mevalonic Acid; Models, Biological; Neoplasms

2012
Glutamine as a supplemental treatment in pediatric and adult oncology patients.
    Expert opinion on investigational drugs, 2012, Volume: 21, Issue:12

    Topics: Adult; Animals; Child; Dietary Supplements; Glutamine; Humans; Neoplasms; Parenteral Nutrition

2012
Cancer metabolism: what we can learn from proteomic analysis by mass spectrometry.
    Cancer genomics & proteomics, 2012, Volume: 9, Issue:6

    Topics: Energy Metabolism; Glutamine; Glycolysis; Humans; L-Lactate Dehydrogenase; Lactic Acid; Lysosomes; Mass Spectrometry; Metabolomics; Neoplasms; Oxidative Stress; Proteomics; Pyruvate Kinase; Reactive Oxygen Species

2012
Altered energy metabolism in cancer: a unique opportunity for therapeutic intervention.
    Cancer biology & therapy, 2013, Volume: 14, Issue:2

    Topics: Antineoplastic Agents; Energy Metabolism; Glutamine; Glycolysis; Humans; Metabolic Networks and Pathways; Mitochondria; Neoplasms; Oxidative Phosphorylation

2013
Endothelial cell metabolism and tumour angiogenesis: glucose and glutamine as essential fuels and lactate as the driving force.
    Journal of internal medicine, 2013, Volume: 273, Issue:2

    Topics: Angiogenesis Inhibitors; Endothelial Cells; Endothelium, Vascular; Glucose; Glutamine; Glycolysis; Humans; Hypoxia; Lactic Acid; Neoplasms; Neovascularization, Pathologic; Oxidation-Reduction

2013
Nutrition in oncologic patients during antiblastic treatment.
    Frontiers in bioscience (Landmark edition), 2013, 01-01, Volume: 18, Issue:1

    Topics: Antineoplastic Agents; Cachexia; Complementary Therapies; Dietary Fats, Unsaturated; Dietary Proteins; Dietary Supplements; Glutamine; Hematopoietic Stem Cell Transplantation; Humans; Intestinal Mucosa; Muscle, Skeletal; Neoplasms; Nutritional Status; Proteoglycans; Stomatitis; Trametes

2013
[Nutrition and tumoral growth].
    Revue medicale de la Suisse romande, 2002, Volume: 122, Issue:7

    Topics: Animals; Arginine; Fatty Acids, Omega-3; Glutamine; Humans; Neoplasms; Nucleotides; Rats

2002
[Modulation of immunity in cancerous patient : an weapon with double edges?].
    Revue medicale de la Suisse romande, 2002, Volume: 122, Issue:7

    Topics: Animals; Arginine; Fatty Acids, Omega-3; Glutamine; Humans; Neoplasms; Nucleotides; Treatment Outcome

2002
BIOCHEMISTRY OF CANCER (METABOLIC ASPECTS).
    Annual review of biochemistry, 1963, Volume: 32

    Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Azaguanine; Azaserine; Carcinoma, Ehrlich Tumor; DNA; DNA, Neoplasm; Floxuridine; Fluorouracil; Folic Acid; Glutamine; Leukemia L1210; Mercaptopurine; Methotrexate; Mitomycin; Neoplasms; Neoplasms, Experimental; Pharmacology; Purines; Puromycin; Pyrimidines; Research; RNA; RNA, Neoplasm; Thioguanine; Thiouracil

1963
Prevention of chemotherapy and radiation toxicity with glutamine.
    Cancer treatment reviews, 2003, Volume: 29, Issue:6

    Topics: Anthracyclines; Antineoplastic Agents; Dietary Supplements; Digestive System; Glutamine; Glutathione; Heart Diseases; Humans; Neoplasms; Paclitaxel; Radiation Injuries

2003
Pathways from glutamine to apoptosis.
    Frontiers in bioscience : a journal and virtual library, 2006, Sep-01, Volume: 11

    Topics: Apoptosis; Cell Proliferation; Glutamic Acid; Glutamine; Humans; Neoplasms; Neurons; Oxidative Stress; Signal Transduction

2006
Cytoprotective agents used in the treatment of patients with cancer.
    Seminars in oncology nursing, 2007, Volume: 23, Issue:3

    Topics: Amifostine; Antineoplastic Agents; Cytoprotection; Fibroblast Growth Factors; Glutamine; Humans; Mesna; Neoplasms; Razoxane

2007
Putting evidence into practice: evidence-based interventions for chemotherapy-induced peripheral neuropathy.
    Clinical journal of oncology nursing, 2007, Volume: 11, Issue:6

    Topics: Acetylcarnitine; Acupuncture Therapy; Anticonvulsants; Antidepressive Agents, Tricyclic; Antineoplastic Agents; Antioxidants; Calcium; Capsaicin; Evidence-Based Medicine; Exercise Therapy; Glutamine; Glutathione; Humans; Infrared Rays; Magnesium; Neoplasms; Nurse's Role; Nursing Research; Oncology Nursing; Patient Education as Topic; Peripheral Nervous System Diseases; Research Design; Sensory System Agents; Transcutaneous Electric Nerve Stimulation; Vitamin E

2007
Brick by brick: metabolism and tumor cell growth.
    Current opinion in genetics & development, 2008, Volume: 18, Issue:1

    Topics: Cell Proliferation; Fatty Acids; Glutamine; Glycolysis; Humans; Lipids; Models, Biological; Neoplasms; Ribosemonophosphates

2008
Membrane cholesterol, tumorigenesis, and the biochemical phenotype of neoplasia.
    CRC critical reviews in biochemistry, 1981, Volume: 11, Issue:4

    Topics: Acetates; Animals; Asparagine; Aspartic Acid; Biological Transport, Active; Cell Division; Cell Membrane Permeability; Cholesterol; Citric Acid Cycle; Electron Spin Resonance Spectroscopy; Glucose; Glutamates; Glutamic Acid; Glutamine; Lipid Bilayers; Liver Neoplasms, Experimental; Membrane Lipids; Mitochondria; Mitochondria, Liver; Models, Biological; Neoplasms; Oxygen Consumption; Phenotype; Purines; Pyrimidines; Pyruvates; Pyruvic Acid; Surface Properties

1981
[Asparagine biosynthesis and tumor growth].
    Vestnik Akademii meditsinskikh nauk SSSR, 1982, Issue:3

    Topics: Adenosine Triphosphate; Animals; Asparaginase; Asparagine; Aspartate-Ammonia Ligase; Glutamine; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Leukocytes; Liver Neoplasms, Experimental; Mice; Neoplasms; Neoplasms, Experimental; Rats; Transaminases

1982
Mitochondrial metabolism of glutamine and glutamate and its physiological significance.
    Physiological reviews, 1983, Volume: 63, Issue:2

    Topics: Acidosis; Animals; Aspartate Aminotransferases; Aspartic Acid; Brain; Cells, Cultured; Energy Metabolism; Glutamate Dehydrogenase; Glutamate-Ammonia Ligase; Glutamates; Glutaminase; Glutamine; Hepatic Encephalopathy; Humans; Intestine, Small; Intracellular Membranes; Kidney; Liver; Mitochondria; Mitochondria, Liver; Muscles; Neoplasms; Organ Specificity; Oxidation-Reduction; Rats

1983
Current indications for intravenous nutritional support in oncology patients.
    Surgical oncology clinics of North America, 1995, Volume: 4, Issue:3

    Topics: Animals; Arginine; Glutamine; Humans; Neoplasms; Nutrition Assessment; Parenteral Nutrition, Total; Preoperative Care; Randomized Controlled Trials as Topic; Treatment Outcome

1995
Glutamine and cancer.
    Annals of surgery, 1993, Volume: 218, Issue:6

    Topics: Antimetabolites, Antineoplastic; Cell Division; Diazooxonorleucine; Glutamine; Humans; Intestinal Mucosa; Intestines; Isoxazoles; Lymphocytes; Muscles; Neoplasms; Parenteral Nutrition, Total; Randomized Controlled Trials as Topic

1993
Potential of antineoplastons in diseases of old age.
    Drugs & aging, 1995, Volume: 7, Issue:3

    Topics: Aged; Aging; Animals; Antineoplastic Agents; Benzeneacetamides; Drug Combinations; Glutamine; Growth Inhibitors; Humans; Neoplasms; Peptides; Phenylacetates; Piperidones

1995
Nutritional pharmacology and malignant disease: a therapeutic modality in patients with cancer.
    The British journal of surgery, 1996, Volume: 83, Issue:5

    Topics: Animals; Arginine; Cell Division; Fatty Acids, Essential; Glutamine; Humans; Immunity; Neoplasms; Nitrogen; Polyribonucleotides; Wound Healing

1996
Role of cysteine and glutathione in HIV infection and other diseases associated with muscle wasting and immunological dysfunction.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 1997, Volume: 11, Issue:13

    Topics: Animals; CD4-Positive T-Lymphocytes; Colitis, Ulcerative; Crohn Disease; Cysteine; Cystine; Fatigue Syndrome, Chronic; Glutamine; Glutathione; HIV Wasting Syndrome; Humans; Killer Cells, Natural; Models, Biological; Muscle, Skeletal; Muscular Diseases; Neoplasms; Sepsis; Wasting Syndrome; Wounds and Injuries

1997
The role of phosphometabolites in cell proliferation, energy metabolism, and tumor therapy.
    Journal of bioenergetics and biomembranes, 1997, Volume: 29, Issue:4

    Topics: Antineoplastic Agents; Apoptosis; Cell Division; Energy Metabolism; Glutamine; Glycolysis; Humans; Neoplasm Metastasis; Neoplasms; Phosphates

1997
[Cachexia in cancer: disturbances in the protein and aminoacid metabolism].
    Nederlands tijdschrift voor geneeskunde, 1999, Jul-03, Volume: 143, Issue:27

    Topics: Amino Acids; Animals; Cachexia; Glutamine; Humans; Muscle, Skeletal; Neoplasms; Proteins

1999
Therapeutic considerations of L-glutamine: a review of the literature.
    Alternative medicine review : a journal of clinical therapeutic, 1999, Volume: 4, Issue:4

    Topics: Digestive System; Digestive System Physiological Phenomena; Glutamine; Humans; Neoplasms; Permeability; Wound Healing; Wounds and Injuries

1999
Glutamine and arginine: immunonutrients for improved health.
    Medicine and science in sports and exercise, 2000, Volume: 32, Issue:7 Suppl

    Topics: Arginine; Burns; Dietary Supplements; Glutamine; Health Status; HIV Infections; Humans; Immunity, Cellular; Immunocompromised Host; Infections; Neoplasms

2000
[Anti-cancer therapy with amino acid imbalance].
    Nihon rinsho. Japanese journal of clinical medicine, 2001, Volume: 59 Suppl 5

    Topics: Amino Acids; Antimetabolites, Antineoplastic; Arginine; Asparagine; Glutamine; Humans; Isoxazoles; Methionine; Neoplasms; Valine

2001
Is immune nutrition the Holy Grail for cancer patients?
    Nestle Nutrition workshop series. Clinical & performance programme, 2000, Volume: 4

    Topics: Arginine; Fatty Acids, Unsaturated; Glutamine; Hospitalization; Humans; Immunotherapy; Length of Stay; Neoplasms; Nutritional Physiological Phenomena; Nutritional Support; Ornithine; Treatment Outcome

2000
Glutamine metabolism in sepsis and infection.
    The Journal of nutrition, 2001, Volume: 131, Issue:9 Suppl

    Topics: Animals; Antineoplastic Agents; Bacterial Infections; Biological Transport; Clinical Trials as Topic; Colon; Disease Models, Animal; Forecasting; Glutamine; Humans; Intestine, Small; Liver; Lung; Muscle, Skeletal; Neoplasms; Sepsis; Tumor Cells, Cultured

2001
Glutamine and cancer.
    The Journal of nutrition, 2001, Volume: 131, Issue:9 Suppl

    Topics: Biological Transport; Clinical Trials as Topic; Cloning, Molecular; Dietary Supplements; Gene Expression Regulation, Enzymologic; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Humans; Neoplasms; Nitrogen; Nutritional Status; Transglutaminases; Tumor Cells, Cultured

2001
Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy.
    The Journal of nutrition, 2001, Volume: 131, Issue:9 Suppl

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Clinical Trials as Topic; Combined Modality Therapy; Diarrhea; Dietary Supplements; Disease Models, Animal; Enteral Nutrition; Glutamine; Humans; Infusions, Intravenous; Neoplasms; Parenteral Nutrition, Total

2001
Nutritional and metabolic support in patients undergoing bone marrow transplantation.
    The American journal of clinical nutrition, 2002, Volume: 75, Issue:2

    Topics: Adult; Bone Marrow Transplantation; Child; Fatty Acids; Glutamine; Graft vs Host Disease; Hematologic Diseases; Humans; Liver Diseases; Neoplasms; Nutritional Support

2002
Glutamine and its relationship with intracellular redox status, oxidative stress and cell proliferation/death.
    The international journal of biochemistry & cell biology, 2002, Volume: 34, Issue:5

    Topics: Animals; Antioxidants; Brain; Cell Death; Cell Division; Glutamine; Glutathione; Humans; Models, Biological; Neoplasms; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species; Signal Transduction

2002
Relevance of glutamine metabolism to tumor cell growth.
    Molecular and cellular biochemistry, 1992, Jul-06, Volume: 113, Issue:1

    Topics: Animals; Biological Transport, Active; Glutamine; Humans; Mitochondria; Neoplasms

1992
Application of metabolic-control logic to the requirements for cell division.
    Biochemical Society transactions, 1990, Volume: 18, Issue:1

    Topics: Animals; Antineoplastic Agents; Cachexia; Cell Division; Glutamine; Glycolysis; Humans; Muscle Proteins; Neoplasms

1990
Glutaminolysis and glycolysis interactions in proliferant cells.
    The International journal of biochemistry, 1990, Volume: 22, Issue:7

    Topics: Animals; Cell Division; Drug Interactions; Glucose; Glutamine; Humans; Neoplasms

1990
Metabolic cooperativity within wounded tissue: hormone-nutrient interactions.
    Progress in clinical and biological research, 1988, Volume: 266

    Topics: Cell Communication; Cell Division; Cells, Cultured; Fibroblasts; Glucose; Glutamine; Hormones; Humans; Neoplasms; Wound Healing

1988
The role of high rates of glycolysis and glutamine utilization in rapidly dividing cells.
    Bioscience reports, 1985, Volume: 5, Issue:5

    Topics: Animals; Cell Division; Energy Metabolism; Glucose; Glutamine; Glycolysis; Humans; Intestinal Mucosa; Kinetics; Lymphocytes; Models, Biological; Neoplasms

1985
Glutamine antagonists in chemotherapy.
    Advances in pharmacology and chemotherapy, 1970, Volume: 8

    Topics: Adult; Aminobutyrates; Animals; Asparaginase; Azaserine; Azo Compounds; Child; Diazooxonorleucine; Drug Combinations; Drug Interactions; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Humans; Hydroxylysine; Leukemia; Leukemia L1210; Liver; Methionine Sulfoximine; Mice; Neoplasms; Rats; RNA, Transfer

1970
Hyperglycaemia and malignancy.
    Journal of the Indian Medical Association, 1968, Aug-16, Volume: 51, Issue:4

    Topics: Animals; Glucose; Glutamine; Humans; Hyperglycemia; Neoplasms; Rats

1968
[Plants with cytostatic effect].
    Il Farmaco; edizione scientifica, 1970, Volume: 25, Issue:6

    Topics: Alkaloids; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Cell Nucleus; Cell Transformation, Neoplastic; Colchicine; Colchicum; DNA; Drug Synergism; Glutamine; Glycolysis; Humans; Leukemia; Mercaptopurine; Methotrexate; Mitosis; Neoplasms; Plant Extracts; Plants, Medicinal; Plants, Toxic; Podophyllum; Prednisone; Purines; Pyrimidines; RNA; Steroids; Vincristine

1970
[Differentiation anomaly of tumor cells and enzymes].
    Naika. Internal medicine, 1971, Volume: 28, Issue:4

    Topics: Animals; Cell Differentiation; Cell Transformation, Neoplastic; Fetus; Glucokinase; Glucosamine; Glutamine; Hexokinase; Isoenzymes; Isomerases; Liver; Mice; Neoplasms; Neoplasms, Experimental; Rats; Transaminases

1971

Trials

25 trial(s) available for glutamine and Benign Neoplasms

ArticleYear
Evaluation of an onco-diet on body composition and inflammatory status of dogs with mammary tumor-Pilot study.
    PloS one, 2023, Volume: 18, Issue:7

    Topics: Animals; Body Composition; C-Reactive Protein; Diet; Docosahexaenoic Acids; Dogs; Fatty Acids, Omega-3; Female; Glutamine; Insulin-Like Growth Factor I; Mastectomy; Neoplasms; Pilot Projects

2023
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
    Annales medico-psychologiques, 2021, Volume: 179, Issue:2

    Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acrylic Resins; Actinobacillus; Acute Disease; Acute Kidney Injury; Adaptor Proteins, Signal Transducing; Adenosine; Adenosine Triphosphate; Administration, Inhalation; Administration, Oral; Adolescent; Adult; Advance Care Planning; Africa, Northern; Age Factors; Aged; Aged, 80 and over; Air Pollutants; Air Pollution; Air Pollution, Indoor; Albendazole; Aluminum Oxide; Anastomosis, Surgical; Ancylostoma; Ancylostomiasis; Androstadienes; Angiogenesis Inhibitors; Angiotensin II; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Antibodies, Bispecific; Antibodies, Viral; Anticoagulants; Antihypertensive Agents; Antinematodal Agents; Antineoplastic Agents; Antineoplastic Agents, Immunological; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Antiporters; Antiviral Agents; Apoptosis; Aptamers, Nucleotide; Aromatase Inhibitors; Asian People; Astrocytes; Atrial Fibrillation; Auditory Threshold; Aurora Kinase B; Australia; Autophagy; Autophagy-Related Protein 5; Autotrophic Processes; Bacillus cereus; Bacillus thuringiensis; Bacterial Proteins; Beclin-1; Belgium; Benzene; Benzene Derivatives; Benzhydryl Compounds; beta Catenin; beta-Arrestin 2; Biliary Tract Diseases; Biofilms; Biofuels; Biomarkers; Biomarkers, Tumor; Biomass; Biomechanical Phenomena; Bioreactors; Biosensing Techniques; Biosynthetic Pathways; Bismuth; Blood Platelets; Bone and Bones; Bone Regeneration; Bortezomib; Botulinum Toxins, Type A; Brain; Brain Injuries; Brain Ischemia; Brain Neoplasms; Breast Neoplasms; Breath Tests; Bronchodilator Agents; Calcium Phosphates; Cannabis; Carbon Dioxide; Carbon Isotopes; Carcinogenesis; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cardiac Resynchronization Therapy; Cardiac Resynchronization Therapy Devices; Cardiomyopathies; Cardiovascular Diseases; Cariostatic Agents; Case Managers; Case-Control Studies; Catalysis; Cation Transport Proteins; CD8-Positive T-Lymphocytes; Cecropia Plant; Cell Adhesion; Cell Count; Cell Differentiation; Cell Division; Cell Line; Cell Line, Tumor; Cell Membrane; Cell Movement; Cell Proliferation; Cell Self Renewal; Cell Survival; Cells, Cultured; Cellular Reprogramming; Cellulose; Charcoal; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chemokines; Chemoradiotherapy; Chemoreceptor Cells; Child; Child Abuse; Child, Preschool; China; Chlorogenic Acid; Chloroquine; Chromatography, Gas; Chronic Disease; Clinical Competence; Coated Materials, Biocompatible; Cochlea; Cohort Studies; Color; Comorbidity; Computer Simulation; Computer-Aided Design; Contraception; Contraceptive Agents, Female; Contrast Media; COP-Coated Vesicles; Coronavirus Infections; Cost of Illness; Coturnix; COVID-19; Creatinine; Cross-Over Studies; Cross-Sectional Studies; Culex; Curriculum; Cyclic N-Oxides; Cytokines; Cytoplasm; Cytotoxicity, Immunologic; Cytotoxins; Databases, Factual; Deep Learning; Delivery, Obstetric; Denitrification; Dental Caries; Denture, Complete; Dexamethasone; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dielectric Spectroscopy; Diet, High-Fat; Dietary Fiber; Disease Models, Animal; Disease Progression; DNA; DNA Copy Number Variations; DNA, Mitochondrial; Dog Diseases; Dogs; Dopaminergic Neurons; Double-Blind Method; Down-Regulation; Doxorubicin; Drug Carriers; Drug Design; Drug Interactions; Drug Resistance, Bacterial; Drug Resistance, Neoplasm; Drug-Related Side Effects and Adverse Reactions; Drugs, Chinese Herbal; Dry Powder Inhalers; Dust; E2F1 Transcription Factor; Ecosystem; Education, Nursing; Education, Nursing, Baccalaureate; Electric Impedance; Electricity; Electrocardiography; Electrochemical Techniques; Electrochemistry; Electrodes; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Endothelial Cells; Environmental Monitoring; Enzyme Inhibitors; Epithelial Cells; Epithelial-Mesenchymal Transition; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Estrogen Receptor Modulators; Europe; Evoked Potentials, Auditory, Brain Stem; Exosomes; Feasibility Studies; Female; Ferricyanides; Ferrocyanides; Fibrinogen; Finite Element Analysis; Fistula; Fluorescent Dyes; Fluorides, Topical; Fluorodeoxyglucose F18; Fluticasone; Follow-Up Studies; Food Contamination; Food Microbiology; Foods, Specialized; Forensic Medicine; Frail Elderly; France; Free Radicals; Fresh Water; Fungi; Fungicides, Industrial; Galactosamine; Gastrointestinal Neoplasms; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Frequency; Genetic Predisposition to Disease; Genotype; Gingival Hemorrhage; Glioblastoma; Glioma; Glomerular Filtration Rate; Glomerulosclerosis, Focal Segmental; Glucose; Glucose Transport Proteins, Facilitative; Glucosides; Glutamine; Glycolysis; Gold; GPI-Linked Proteins; Gram-Negative Bacteria; Gram-Positive Bacteria; Graphite; Haplotypes; HCT116 Cells; Healthy Volunteers; Hearing Loss; Heart Failure; Hedgehog Proteins; HEK293 Cells; HeLa Cells; Hemodynamics; Hemorrhage; Hepatocytes; Hippo Signaling Pathway; Histone Deacetylases; Homeostasis; Hospital Mortality; Hospitalization; Humans; Hydantoins; Hydrazines; Hydrogen Peroxide; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Hydroxylamines; Hypoglycemic Agents; Immunity, Innate; Immunoglobulin G; Immunohistochemistry; Immunologic Factors; Immunomodulation; Immunophenotyping; Immunotherapy; Incidence; Indazoles; Indonesia; Infant; Infant, Newborn; Infarction, Middle Cerebral Artery; Inflammation; Injections, Intramuscular; Insecticides; Insulin-Like Growth Factor I; Insurance, Health; Intention to Treat Analysis; Interleukin-1 Receptor-Associated Kinases; Interleukin-6; Intrauterine Devices; Intrauterine Devices, Copper; Iron; Ischemia; Jordan; Keratinocytes; Kidney; Kidney Diseases; Kir5.1 Channel; Klebsiella Infections; Klebsiella pneumoniae; Lab-On-A-Chip Devices; Laparoscopy; Lasers; Lasers, Semiconductor; Lenalidomide; Leptin; Lethal Dose 50; Levonorgestrel; Limit of Detection; Lipid Metabolism; Lipid Metabolism Disorders; Lipogenesis; Lipopolysaccharides; Liquid Biopsy; Liver; Liver Abscess, Pyogenic; Liver Cirrhosis; Liver Diseases; Liver Neoplasms; Longevity; Lung Neoplasms; Luteolin; Lymph Nodes; Lymphocyte Activation; Macaca fascicularis; Macrophages; Mad2 Proteins; Magnetic Resonance Imaging; Male; Mammary Glands, Human; Manganese; Manganese Compounds; MAP Kinase Signaling System; Materials Testing; Maternal Health Services; MCF-7 Cells; Medicaid; Medicine, Chinese Traditional; Melanoma; Membrane Proteins; Mental Health; Mercury; Metal Nanoparticles; Metals, Heavy; Metformin; Methionine Adenosyltransferase; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Knockout; Mice, Nude; Microalgae; Microbial Sensitivity Tests; Microglia; MicroRNAs; Microscopy, Atomic Force; Microscopy, Electron, Scanning; Middle Aged; Mitochondria; Mitochondrial Proteins; Mitral Valve; Mitral Valve Insufficiency; Models, Anatomic; Molecular Structure; Molybdenum; Monocarboxylic Acid Transporters; Moths; MPTP Poisoning; Multigene Family; Multiparametric Magnetic Resonance Imaging; Multiple Myeloma; Muscle, Skeletal; Mutagens; Mutation; Myeloid Cells; Nanocomposites; Nanofibers; Nanomedicine; Nanoparticles; Nanowires; Neoadjuvant Therapy; Neomycin; Neoplasm Grading; Neoplasm Recurrence, Local; Neoplasms; Neoplastic Stem Cells; Neostriatum; Neovascularization, Pathologic; Netherlands; Neuromuscular Agents; Neurons; NF-E2-Related Factor 2; NF-kappa B; Nickel; Nitrogen Oxides; Non-alcoholic Fatty Liver Disease; Nucleosides; Nucleotidyltransferases; Nutritional Status; Obesity, Morbid; Ofloxacin; Oils, Volatile; Oligopeptides; Oncogene Protein v-akt; Optical Imaging; Organic Cation Transport Proteins; Organophosphonates; Osteoarthritis; Osteoarthritis, Hip; Osteoarthritis, Knee; Osteoblasts; Osteogenesis; Oxidation-Reduction; Oxidative Stress; Oxides; Oxygen Isotopes; Pancreas; Pancreaticoduodenectomy; Pandemics; Particle Size; Particulate Matter; Patient Acceptance of Health Care; Patient Compliance; PC-3 Cells; Peptide Fragments; Peptides; Periodontal Attachment Loss; Periodontal Index; Periodontal Pocket; Periodontitis; Peroxides; Peru; Pest Control, Biological; Phosphatidylinositol 3-Kinase; Phosphatidylinositol 3-Kinases; Phylogeny; Pilot Projects; Piperidines; Plant Bark; Plant Extracts; Plant Leaves; Plasmids; Platelet Function Tests; Pneumonia, Viral; Podocytes; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Polyethylene Terephthalates; Polymers; Polymorphism, Single Nucleotide; Porosity; Portugal; Positron-Emission Tomography; Postoperative Complications; Postural Balance; Potassium Channels, Inwardly Rectifying; Povidone; Powders; Precancerous Conditions; Precision Medicine; Predictive Value of Tests; Pregnancy; Prenatal Care; Prognosis; Promoter Regions, Genetic; Prospective Studies; Prostatectomy; Prostatic Neoplasms; Proteasome Inhibitors; Protective Agents; Protein Binding; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein Transport; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-akt; Psychiatric Nursing; PTEN Phosphohydrolase; Pulmonary Embolism; Pyrimethamine; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Rats, Wistar; Reactive Oxygen Species; Receptor, ErbB-2; Receptor, IGF Type 1; Receptors, Estrogen; Receptors, G-Protein-Coupled; Recombinational DNA Repair; Recovery of Function; Regional Blood Flow; Renal Dialysis; Renin; Renin-Angiotensin System; Reperfusion Injury; Reproducibility of Results; Republic of Korea; Respiratory Distress Syndrome; Retrospective Studies; Rhodamines; Risk Assessment; Risk Factors; RNA, Long Noncoding; RNA, Messenger; Running; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Salinity; Salmeterol Xinafoate; Sarcoma; Seasons; Shoulder Injuries; Signal Transduction; Silicon Dioxide; Silver; Sirtuin 1; Sirtuins; Skull Fractures; Social Determinants of Health; Sodium; Sodium Fluoride; Sodium Potassium Chloride Symporter Inhibitors; Sodium-Glucose Transporter 2 Inhibitors; Soil; Soil Pollutants; Spain; Spectrophotometry; Spectroscopy, Fourier Transform Infrared; Staphylococcal Protein A; Staphylococcus aureus; Stem Cells; Stereoisomerism; Stomach Neoplasms; Streptomyces; Strontium; Structure-Activity Relationship; Students, Nursing; Substance-Related Disorders; Succinic Acid; Sulfur; Surface Properties; Survival Rate; Survivin; Symporters; T-Lymphocytes; Temozolomide; Tensile Strength; Thiazoles; Thiobacillus; Thiohydantoins; Thiourea; Thrombectomy; Time Factors; Titanium; Tobacco Mosaic Virus; Tobacco Use Disorder; Toll-Like Receptor 4; Toluene; Tomography, X-Ray Computed; TOR Serine-Threonine Kinases; Toxicity Tests, Acute; Toxicity Tests, Subacute; Transcriptional Activation; Treatment Outcome; Troponin I; Tumor Cells, Cultured; Tumor Escape; Tumor Hypoxia; Tumor Microenvironment; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha; Tyrosine; Ubiquitin-Protein Ligases; Ubiquitination; Ultrasonic Waves; United Kingdom; United States; United States Department of Veterans Affairs; Up-Regulation; Urea; Uric Acid; Urinary Bladder Neoplasms; Urinary Bladder, Neurogenic; Urine; Urodynamics; User-Computer Interface; Vemurafenib; Verbenaceae; Veterans; Veterans Health; Viral Load; Virtual Reality; Vitiligo; Water Pollutants, Chemical; Wildfires; Wnt Signaling Pathway; Wound Healing; X-Ray Diffraction; Xenograft Model Antitumor Assays; Xylenes; Young Adult; Zinc; Zinc Oxide; Zinc Sulfate; Zoonoses

2021
In Vivo PET Assay of Tumor Glutamine Flux and Metabolism: In-Human Trial of
    Radiology, 2018, Volume: 287, Issue:2

    Topics: Adult; Aged; Biomarkers, Tumor; Cell Transformation, Neoplastic; Female; Fluorine Radioisotopes; Glutamine; Humans; Male; Middle Aged; Neoplasms; Positron-Emission Tomography; Tissue Distribution; United States; United States Food and Drug Administration

2018
Arginine, glutamine, and fish oil supplementation in cancer patients treated with concurrent chemoradiotherapy: A randomized control study.
    Current problems in cancer, 2020, Volume: 44, Issue:1

    Topics: Arginine; Chemoradiotherapy; Dietary Supplements; Female; Fish Oils; Glutamine; Hematologic Diseases; Humans; Incidence; Kaplan-Meier Estimate; Male; Middle Aged; Neoplasms; Patient Compliance; Severity of Illness Index; Treatment Outcome

2020
The impact of microbial immune enteral nutrition on the patients with acute radiation enteritis in bowel function and immune status.
    Cell biochemistry and biophysics, 2014, Volume: 69, Issue:2

    Topics: Acute Disease; Aged; Calcitonin; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Chromatography, High Pressure Liquid; Enteral Nutrition; Enteritis; Female; Fish Oils; Glutamine; Humans; Killer Cells, Natural; Lactulose; Male; Mannitol; Middle Aged; Neoplasms; Nutritional Status; Prealbumin; Probiotics; Protein Precursors; Serum Albumin

2014
Effects of oral glutamine during abdominal radiotherapy on chronic radiation enteritis: a randomized controlled trial.
    Nutrition (Burbank, Los Angeles County, Calif.), 2015, Volume: 31, Issue:1

    Topics: Administration, Oral; Aged; Chronic Disease; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Double-Blind Method; Enteritis; Female; Gastrointestinal Tract; Glutamine; Humans; Male; Middle Aged; Neoplasms; Nutritional Status; Radiotherapy

2015
Glutamine-enriched nutrition does not reduce mucosal morbidity or complications after stem-cell transplantation for childhood malignancies: a prospective randomized study.
    Transplantation, 2011, Jun-27, Volume: 91, Issue:12

    Topics: Adolescent; Analgesia; Child; Child, Preschool; Double-Blind Method; Female; Glutamine; Hematopoietic Stem Cell Transplantation; Humans; Infant; Male; Mucositis; Mucous Membrane; Neoplasms; Odds Ratio; Parenteral Nutrition; Prospective Studies; Recurrence; Stem Cells; Treatment Outcome

2011
The protective effects of glutamine on radiation-induced diarrhea.
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2013, Volume: 21, Issue:4

    Topics: Aged; Antidiarrheals; Diarrhea; Female; Glutamine; Humans; Male; Middle Aged; Neoplasms; Turkey

2013
Oral glutamine in paediatric oncology patients: a dose finding study.
    European journal of clinical nutrition, 2003, Volume: 57, Issue:1

    Topics: Administration, Oral; Adolescent; Ammonia; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Glutamine; Humans; Inflammation; Infusions, Parenteral; Intestinal Mucosa; Intubation, Gastrointestinal; Male; Maximum Tolerated Dose; Metabolic Clearance Rate; Neoplasms; Safety

2003
Pharmacokinetics of phenylacetate administered as a 30-min infusion in children with refractory cancer.
    Cancer chemotherapy and pharmacology, 2003, Volume: 52, Issue:5

    Topics: Adolescent; Adult; Antineoplastic Agents; Biotransformation; Child; Child, Preschool; Chromatography, High Pressure Liquid; Drug Resistance, Neoplasm; Female; Glutamine; Half-Life; Humans; Infant; Infusions, Intravenous; Male; Models, Biological; Neoplasms; Phenylacetates; Spectrophotometry, Ultraviolet

2003
Effects of oral glutamine supplementation on children with solid tumors receiving chemotherapy.
    Pediatric hematology and oncology, 2006, Volume: 23, Issue:4

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Body Weights and Measures; Child; Child, Preschool; Female; Glutamine; Humans; Immune System; Immunologic Factors; Infant; Male; Neoplasms; Nutritional Status; Parenteral Nutrition; Treatment Outcome

2006
The effect of oral glutamine on 5-fluorouracil/leucovorin-induced mucositis/stomatitis assessed by intestinal permeability test.
    Clinical nutrition (Edinburgh, Scotland), 2007, Volume: 26, Issue:1

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Chromium Radioisotopes; Edetic Acid; Female; Fluorouracil; Glutamine; Humans; Intestinal Absorption; Leucovorin; Male; Middle Aged; Mucositis; Neoplasms; Permeability; Severity of Illness Index; Stomatitis; Treatment Outcome

2007
The effect of high-dose enteral glutamine on the incidence and severity of mucositis in paediatric oncology patients.
    European journal of clinical nutrition, 2009, Volume: 63, Issue:1

    Topics: Administration, Oral; Adolescent; Ammonia; Antineoplastic Agents; Child; Child, Preschool; Enteral Nutrition; Female; Gastrointestinal Tract; Glutamine; Humans; Male; Mucositis; Neoplasms; Parenteral Nutrition; Young Adult

2009
A randomized, double-blind, placebo-controlled trial of a beta-hydroxyl beta-methyl butyrate, glutamine, and arginine mixture for the treatment of cancer cachexia (RTOG 0122).
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2008, Volume: 16, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Area Under Curve; Arginine; Cachexia; Dietary Supplements; Double-Blind Method; Drug Therapy, Combination; Female; Glutamine; Humans; Male; Middle Aged; Neoplasms; Placebos; Plethysmography; Quality of Life; Statistics, Nonparametric; Treatment Outcome; Valerates

2008
Prevention of docetaxel- or paclitaxel-associated taste alterations in cancer patients with oral glutamine: a randomized, placebo-controlled, double-blind study.
    The oncologist, 2008, Volume: 13, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Docetaxel; Double-Blind Method; Dysgeusia; Female; Glutamine; Humans; Male; Middle Aged; Neoplasms; Paclitaxel; Risk Factors; Taste; Taxoids; Treatment Outcome

2008
Disposition of phenylbutyrate and its metabolites, phenylacetate and phenylacetylglutamine.
    Journal of clinical pharmacology, 1995, Volume: 35, Issue:4

    Topics: Adult; Aged; Female; Glutamine; Humans; Male; Middle Aged; Models, Biological; Neoplasms; Phenylacetates; Phenylbutyrates

1995
A phase I and pharmacokinetic study of intravenous phenylacetate in patients with cancer.
    Cancer research, 1994, Apr-01, Volume: 54, Issue:7

    Topics: Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Drug Administration Schedule; Female; Glioblastoma; Glutamine; Humans; Infusions, Intravenous; Injections, Intravenous; Male; Middle Aged; Neoplasms; Phenylacetates

1994
Oral glutamine to prevent chemotherapy induced stomatitis: a pilot study.
    The Journal of laboratory and clinical medicine, 1996, Volume: 127, Issue:2

    Topics: Acquired Immunodeficiency Syndrome; Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Carboplatin; Cyclophosphamide; Dacarbazine; Double-Blind Method; Doxorubicin; Etoposide; Female; Fluorouracil; Glutamine; Humans; Ifosfamide; Male; Neoplasms; Pilot Projects; Placebos; Sarcoma, Kaposi; Stomatitis; Vincristine

1996
Toxicological study on antineoplastons A-10 and AS2-1 in cancer patients.
    The Kurume medical journal, 1995, Volume: 42, Issue:4

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Benzeneacetamides; Child; Drug Combinations; Female; Glutamine; Humans; Male; Middle Aged; Neoplasms; Phenylacetates; Piperidones

1995
Metabolic and immune effects of dietary arginine, glutamine and omega-3 fatty acids supplementation in immunocompromised patients.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 1998, Volume: 81, Issue:5

    Topics: Adult; Arginine; Burns; CD4-CD8 Ratio; Dietary Supplements; Enteral Nutrition; Fatty Acids, Omega-3; Female; Glutamine; Humans; Immunocompromised Host; Immunoglobulins; Lymphocyte Count; Male; Middle Aged; Neoplasms; Nutritional Status; Phenotype; Prospective Studies; Treatment Outcome; Wounds and Injuries

1998
A Phase I and pharmacological study of the glutamine antagonist acivicin with the amino acid solution aminosyn in patients with advanced solid malignancies.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1998, Volume: 4, Issue:11

    Topics: Adult; Aged; Amino Acids; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System; Electrolytes; Female; Glucose; Glutamine; Humans; Isoxazoles; Male; Middle Aged; Neoplasms; Parenteral Nutrition Solutions; Solutions; Thrombocytopenia; Treatment Outcome

1998
A phase I dose escalation and bioavailability study of oral sodium phenylbutyrate in patients with refractory solid tumor malignancies.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2001, Volume: 7, Issue:8

    Topics: Administration, Oral; Adult; Aged; Area Under Curve; Biological Availability; Dose-Response Relationship, Drug; Edema; Fatigue; Female; Glutamine; Humans; Hypocalcemia; Male; Middle Aged; Nausea; Neoplasms; Nervous System Diseases; Phenylacetates; Phenylbutyrates; Treatment Outcome; Vomiting

2001
A Phase I clinical and pharmacological evaluation of sodium phenylbutyrate on an 120-h infusion schedule.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2001, Volume: 7, Issue:10

    Topics: Adult; Antineoplastic Agents; Chromatography, High Pressure Liquid; Disorders of Excessive Somnolence; Dose-Response Relationship, Drug; Fatigue; Female; Glutamine; Humans; Hypokalemia; Infusions, Intravenous; Male; Metabolic Clearance Rate; Nausea; Neoplasms; Neutropenia; Patient Dropouts; Phenylacetates; Phenylbutyrates; Prostate-Specific Antigen; Prostatic Neoplasms; Time Factors; Tumor Cells, Cultured; Uric Acid

2001
Reversal of cancer-related wasting using oral supplementation with a combination of beta-hydroxy-beta-methylbutyrate, arginine, and glutamine.
    American journal of surgery, 2002, Volume: 183, Issue:4

    Topics: Aged; Arginine; Body Composition; Cachexia; Dietary Supplements; Double-Blind Method; Drug Combinations; Female; Glutamine; Humans; Male; Middle Aged; Muscle, Skeletal; Neoplasms; Treatment Outcome; Valerates

2002
Phase I study of succinylated acinetobacter L-glutaminase-L-asparaginase.
    Cancer treatment reports, 1979, Volume: 63, Issue:6

    Topics: Acinetobacter; Adolescent; Alkalosis, Respiratory; Amidohydrolases; Asparagine; Child; Child, Preschool; Clinical Trials as Topic; Drug Evaluation; Female; Glutamine; Humans; Hyperglycemia; Leukemia, Lymphoid; Male; Neoplasms

1979

Other Studies

247 other study(ies) available for glutamine and Benign Neoplasms

ArticleYear
Chemical genetics reveals a complex functional ground state of neural stem cells.
    Nature chemical biology, 2007, Volume: 3, Issue:5

    Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells

2007
Glutamine Antagonist GA-607 Causes a Dramatic Accumulation of FGAR which can be used to Monitor Target Engagement.
    Current drug metabolism, 2021, Volume: 22, Issue:9

    Topics: Animals; Biomarkers, Pharmacological; Biomarkers, Tumor; Chromatography, Liquid; Drug Development; Glutamine; Glycine; Mass Spectrometry; Metabolic Networks and Pathways; Mice; Neoplasms; Ribonucleotides

2021
Glutamine promotes escape from therapy-induced senescence in tumor cells.
    Aging, 2021, 09-07, Volume: 13, Issue:17

    Topics: A549 Cells; Amino Acid Transport System ASC; Cell Cycle Checkpoints; Cell Proliferation; Cellular Senescence; Enzyme Activation; Glutamate-Ammonia Ligase; Glutamine; Humans; MCF-7 Cells; Minor Histocompatibility Antigens; Neoplasm Recurrence, Local; Neoplasms; Neoplastic Stem Cells; Nitrogen; Nucleotides; Senescence-Associated Secretory Phenotype; Tumor Escape

2021
CISD3 inhibition drives cystine-deprivation induced ferroptosis.
    Cell death & disease, 2021, 09-08, Volume: 12, Issue:9

    Topics: Animals; Cell Line, Tumor; Cell Survival; Cystine; Disease Progression; Ferroptosis; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Glutamine; Homeostasis; Humans; Iron; Iron-Sulfur Proteins; Lipid Peroxides; Mice, Nude; Mitochondria; Mitochondrial Dynamics; Mitochondrial Proteins; Mitophagy; Neoplasms; Organophosphorus Compounds; Piperazines; Ubiquinone; Xenograft Model Antitumor Assays

2021
SnapShot: Cancer metabolism.
    Molecular cell, 2021, 09-16, Volume: 81, Issue:18

    Topics: Amino Acids; Citric Acid Cycle; Energy Metabolism; Glucose; Glutamine; Glycolysis; Humans; Metabolic Networks and Pathways; Neoplasms; Nucleotides

2021
Glutamine Metabolism Regulators Associated with Cancer Development and the Tumor Microenvironment: A Pan-Cancer Multi-Omics Analysis.
    Genes, 2021, 08-25, Volume: 12, Issue:9

    Topics: Biomarkers, Tumor; Carcinogenesis; Datasets as Topic; DNA Copy Number Variations; DNA Methylation; Epigenesis, Genetic; Epigenomics; Female; Gene Expression Regulation, Neoplastic; Glutamine; Humans; Kaplan-Meier Estimate; Male; Metabolic Networks and Pathways; Neoplasms; Polymorphism, Single Nucleotide; RNA-Seq; Tumor Microenvironment

2021
Fibroblast pyruvate carboxylase is required for collagen production in the tumour microenvironment.
    Nature metabolism, 2021, Volume: 3, Issue:11

    Topics: Animals; Cancer-Associated Fibroblasts; Cell Line; Citric Acid Cycle; Collagen; Disease Susceptibility; Enzyme Activation; Fibrosis; Gene Expression Regulation, Enzymologic; Glutamine; Humans; Lactic Acid; Mice; Neoplasms; Protein Biosynthesis; Pyruvate Carboxylase; Transforming Growth Factor beta; Tumor Microenvironment

2021
Succinate receptor 1 inhibits mitochondrial respiration in cancer cells addicted to glutamine.
    Cancer letters, 2022, 02-01, Volume: 526

    Topics: Cell Line, Tumor; Cell Respiration; Glutamine; HEK293 Cells; Humans; Mitochondria; Neoplasms; Receptors, G-Protein-Coupled; Transfection

2022
New insights into the molecular mechanisms of glutaminase C inhibitors in cancer cells using serial room temperature crystallography.
    The Journal of biological chemistry, 2022, Volume: 298, Issue:2

    Topics: Crystallography; Enzyme Inhibitors; Glutaminase; Glutamine; Neoplasms; Sulfides; Temperature; Thiadiazoles

2022
Systemically Applicable Glutamine-Functionalized Polymer Exerting Multivalent Interaction with Tumors Overexpressing ASCT2.
    ACS applied bio materials, 2021, 10-18, Volume: 4, Issue:10

    Topics: Amino Acid Transport System ASC; Glutamine; Humans; Minor Histocompatibility Antigens; Neoplasms; Polymers

2021
A biomimetic ZIF nanoagent for synergistic regulation of glutamine metabolism and intracellular acidosis of cancer.
    Chemical communications (Cambridge, England), 2022, Feb-01, Volume: 58, Issue:10

    Topics: Animals; Biomimetic Materials; Cell Survival; Enzyme Inhibitors; Glutamine; Humans; Imidazoles; Lactic Acid; MCF-7 Cells; Nanoparticles; Neoplasms; Sulfides; Thiadiazoles; Zeolites

2022
Tumor-derived exosomes co-delivering aggregation-induced emission luminogens and proton pump inhibitors for tumor glutamine starvation therapy and enhanced type-I photodynamic therapy.
    Biomaterials, 2022, Volume: 283

    Topics: Cell Line, Tumor; Exosomes; Glutamine; Humans; Neoplasms; Photochemotherapy; Photosensitizing Agents; Proton Pump Inhibitors

2022
MRI assessment of glutamine uptake correlates with the distribution of glutamine transporters and cancer stem cell markers.
    Scientific reports, 2022, 04-01, Volume: 12, Issue:1

    Topics: Amino Acid Transport System ASC; Animals; Glutamine; Humans; Magnetic Resonance Imaging; Mice; Minor Histocompatibility Antigens; Neoplasms; Neoplastic Stem Cells

2022
Cellular signals converge at the NOX2-SHP-2 axis to induce reductive carboxylation in cancer cells.
    Cell chemical biology, 2022, 07-21, Volume: 29, Issue:7

    Topics: Cell Line, Tumor; Citric Acid Cycle; Glutamine; Isocitrate Dehydrogenase; Neoplasms; Oxidation-Reduction; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 11

2022
VGLL3 increases the dependency of cancer cells on de novo nucleotide synthesis through GART expression.
    Journal of cellular biochemistry, 2022, Volume: 123, Issue:6

    Topics: Carbon-Nitrogen Ligases; Cell Line, Tumor; Glutamine; Humans; Neoplasms; Nucleotides; Phosphoribosylglycinamide Formyltransferase; Transcription Factors

2022
Macrophage mitochondrial fission improves cancer cell phagocytosis induced by therapeutic antibodies and is impaired by glutamine competition.
    Nature cancer, 2022, Volume: 3, Issue:4

    Topics: Cytophagocytosis; Cytoskeletal Proteins; Glutamine; Humans; Macrophages; Mitochondrial Dynamics; Neoplasms; Phagocytosis; Protein Kinase C-theta; Wiskott-Aldrich Syndrome Protein

2022
Ammonia stimulates SCAP/Insig dissociation and SREBP-1 activation to promote lipogenesis and tumour growth.
    Nature metabolism, 2022, Volume: 4, Issue:5

    Topics: Ammonia; Glucose; Glutamine; Humans; Insulin; Lipogenesis; Neoplasms; Sterol Regulatory Element Binding Protein 1; Sterols

2022
Characterizing unexpected interactions of a glutamine transporter inhibitor with members of the SLC1A transporter family.
    The Journal of biological chemistry, 2022, Volume: 298, Issue:8

    Topics: Amino Acid Transport System ASC; Amino Acid Transport Systems; Amino Acids, Neutral; Glutamine; Humans; Minor Histocompatibility Antigens; Neoplasms

2022
Glutamine deficiency in solid tumor cells confers resistance to ribosomal RNA synthesis inhibitors.
    Nature communications, 2022, 06-28, Volume: 13, Issue:1

    Topics: Glutamine; Humans; Neoplasms; Nucleic Acid Synthesis Inhibitors; Ribosomes; RNA Precursors; RNA, Ribosomal; Tumor Suppressor Protein p53

2022
Trabectedin suppresses escape from therapy-induced senescence in tumor cells by interfering with glutamine metabolism.
    Biochemical pharmacology, 2022, Volume: 202

    Topics: Amino Acid Transport System ASC; Cell Cycle Checkpoints; Cell Line, Tumor; Cellular Senescence; Glutamine; Humans; Minor Histocompatibility Antigens; Neoplasms; Neoplastic Stem Cells; Trabectedin

2022
Biomimetic Nanoplatform Loading Type I Aggregation-Induced Emission Photosensitizer and Glutamine Blockade to Regulate Nutrient Partitioning for Enhancing Antitumor Immunotherapy.
    ACS nano, 2022, 07-26, Volume: 16, Issue:7

    Topics: Biomimetics; Cell Line, Tumor; Glutamine; Humans; Immunologic Factors; Immunotherapy; Neoplasms; Nutrients; Photosensitizing Agents; Tumor Microenvironment

2022
Sirpiglenastat (DRP-104) Induces Antitumor Efficacy through Direct, Broad Antagonism of Glutamine Metabolism and Stimulation of the Innate and Adaptive Immune Systems.
    Molecular cancer therapeutics, 2022, 10-07, Volume: 21, Issue:10

    Topics: Amino Acids, Essential; Cell Line, Tumor; Diazooxonorleucine; Glutamine; Humans; Immune System; Neoplasms; Prodrugs; Tumor Microenvironment

2022
The mitochondrial enzyme FAHD1 regulates complex II activity in breast cancer cells and is indispensable for basal BT-20 cells in vitro.
    FEBS letters, 2022, Volume: 596, Issue:21

    Topics: Apoptosis; Cell Line; Glutamine; Hydrolases; Mitochondria; Neoplasms

2022
In vivo isotope tracing reveals a requirement for the electron transport chain in glucose and glutamine metabolism by tumors.
    Science advances, 2022, 09-02, Volume: 8, Issue:35

    Topics: Animals; Electron Transport; Electron Transport Complex I; Glucose; Glutamine; Humans; Isotopes; Mice; NAD; Neoplasms; Saccharomyces cerevisiae Proteins

2022
Serum diamine oxidase activity derived from response to chemotherapy affects adverse events and serum amino acid levels.
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2022, Volume: 30, Issue:11

    Topics: Amine Oxidase (Copper-Containing); Antineoplastic Agents; Glutamine; Humans; Intestinal Mucosa; Neoplasms; Prospective Studies; Quality of Life

2022
A novel gene signature unveils three distinct immune-metabolic rewiring patterns conserved across diverse tumor types and associated with outcomes.
    Frontiers in immunology, 2022, Volume: 13

    Topics: Carbon; Glucose; Glutamine; Hexosamines; Humans; Hypoglycemic Agents; Lactates; Lipids; Neoplasms; Tumor Microenvironment

2022
Inhibition of alanine-serine-cysteine transporter 2-mediated auto-enhanced photodynamic cancer therapy of co-nanoassembly between V-9302 and photosensitizer.
    Journal of colloid and interface science, 2023, Volume: 629, Issue:Pt B

    Topics: Animals; Cell Line, Tumor; Cysteine; Glutamine; Mice; Nanoparticles; Neoplasms; Photochemotherapy; Photosensitizing Agents; Reactive Oxygen Species

2023
Inhibiting glutamine utilization creates a synthetic lethality for suppression of ATP citrate lyase in KRas-driven cancer cells.
    PloS one, 2022, Volume: 17, Issue:10

    Topics: Adenosine Diphosphate Ribose; Aminooxyacetic Acid; ATP Citrate (pro-S)-Lyase; Glutamates; Glutamine; Humans; Ketoglutaric Acids; Mechanistic Target of Rapamycin Complex 1; Mechanistic Target of Rapamycin Complex 2; Neoplasms; Oleic Acids; Oxaloacetates; Phosphatidic Acids; Proto-Oncogene Proteins c-akt; Transaminases

2022
Hepatic glutamine synthetase controls N
    Nature chemical biology, 2023, Volume: 19, Issue:3

    Topics: Ammonia; Animals; Glutamate-Ammonia Ligase; Glutamic Acid; Glutamine; Homeostasis; Humans; Liver; Mammals; Mice; Neoplasms

2023
Probabilistic model checking of cancer metabolism.
    Scientific reports, 2022, 11-07, Volume: 12, Issue:1

    Topics: Cell Hypoxia; Glucose; Glutamine; Humans; Models, Statistical; Neoplasms

2022
Discovery of DRP-104, a tumor-targeted metabolic inhibitor prodrug.
    Science advances, 2022, 11-18, Volume: 8, Issue:46

    Topics: CD8-Positive T-Lymphocytes; Diazooxonorleucine; Enzyme Inhibitors; Glutamine; Humans; Neoplasms; Prodrugs

2022
α-ketoglutarate suppresses immediate early gene expression in cancer cells.
    Biochemical and biophysical research communications, 2022, 12-31, Volume: 637

    Topics: Citric Acid Cycle; Combined Modality Therapy; Genes, Immediate-Early; Glutamine; Ketoglutaric Acids; Neoplasms

2022
Cancer cell survival depends on collagen uptake into tumor-associated stroma.
    Nature communications, 2022, 11-18, Volume: 13, Issue:1

    Topics: Animals; Cell Survival; Collagen; Glutamine; Humans; Immunoconjugates; Mice; Microfilament Proteins; Neoplasms; Receptors, Cell Surface

2022
Glutamine-dependent effects of nitric oxide on cancer cells subjected to hypoxia-reoxygenation.
    Nitric oxide : biology and chemistry, 2023, 01-01, Volume: 130

    Topics: Energy Metabolism; Glutamine; Humans; Hypoxia; Ketoglutaric Acids; Neoplasms; Nitric Oxide

2023
Bivalves Transmissible Neoplasia: Biochemical Aspects of Contagious Cancer in a Clam Macoma Balthica.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2022, Nov-25, Volume: 56, Issue:6

    Topics: Amino Acids; Animals; Bivalvia; Glutamine; Glutathione; Humans; Hydrocortisone; Neoplasms; Protein Carbonylation; Tandem Mass Spectrometry

2022
Bioinspired nanocatalytic tumor therapy by simultaneous reactive oxygen species generation enhancement and glutamine pathway-mediated glutathione depletion.
    Journal of materials chemistry. B, 2022, 12-22, Volume: 11, Issue:1

    Topics: Glutamine; Glutathione; Gold; Humans; Hydrogen Peroxide; Metal Nanoparticles; Neoplasms; Reactive Oxygen Species

2022
The mitochondrial chaperone TRAP-1 regulates the glutamine metabolism in tumor cells.
    Mitochondrion, 2023, Volume: 69

    Topics: Adenosine Triphosphate; Amino Acid Transport System ASC; Energy Metabolism; Glucose; Glutamine; Glycolysis; HSP90 Heat-Shock Proteins; Humans; Minor Histocompatibility Antigens; Mitochondria; Molecular Chaperones; Neoplasms

2023
Tumor-targeted nanoflowers regulate glutamine metabolism and amplify oxidative stress for synergistic therapy.
    Chemical communications (Cambridge, England), 2023, May-23, Volume: 59, Issue:42

    Topics: Cell Line, Tumor; Glutamine; Humans; Neoplasms; Oxidative Stress

2023
Alanine supplementation exploits glutamine dependency induced by SMARCA4/2-loss.
    Nature communications, 2023, 05-20, Volume: 14, Issue:1

    Topics: Adenosine Triphosphatases; Dietary Supplements; DNA Helicases; Glucose Transporter Type 1; Glutamine; Humans; Neoplasms; Nuclear Proteins; Transcription Factors

2023
Synthesis, Characterization, and Biological Evaluation of Radiolabeled Glutamine Conjugated Polymeric Nanoparticles: A Simple Approach for Tumor Imaging.
    ACS applied bio materials, 2023, 06-19, Volume: 6, Issue:6

    Topics: Animals; Glutamine; Nanoparticles; Neoplasms; Polylactic Acid-Polyglycolic Acid Copolymer; Rats; Technetium; Tissue Distribution

2023
Detachable MOF-Based Core/Shell Nanoreactor for Cancer Dual-Starvation Therapy With Reversing Glucose and Glutamine Metabolisms.
    Small (Weinheim an der Bergstrasse, Germany), 2023, Volume: 19, Issue:42

    Topics: Cell Line, Tumor; Glucose; Glucose Oxidase; Glutamine; Humans; Metal-Organic Frameworks; Nanotechnology; Neoplasms; Reactive Oxygen Species; Tumor Microenvironment

2023
Differential Effects of Glutamine Inhibition Strategies on Antitumor CD8 T Cells.
    Journal of immunology (Baltimore, Md. : 1950), 2023, 08-15, Volume: 211, Issue:4

    Topics: Animals; CD8-Positive T-Lymphocytes; Diazooxonorleucine; Glutamine; Mice; Neoplasms

2023
SLC38A2 and glutamine signalling in cDC1s dictate anti-tumour immunity.
    Nature, 2023, Volume: 620, Issue:7972

    Topics: Amino Acid Transport System A; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; CD8-Positive T-Lymphocytes; Dendritic Cells; Glutamine; Neoplasms; Proto-Oncogene Proteins; Signal Transduction; Tumor Suppressor Proteins

2023
CAFs targeted ultrasound-responsive nanodroplets loaded V9302 and GLULsiRNA to inhibit melanoma growth via glutamine metabolic reprogramming and tumor microenvironment remodeling.
    Journal of nanobiotechnology, 2023, Jul-08, Volume: 21, Issue:1

    Topics: Amino Acid Transport System ASC; Cancer-Associated Fibroblasts; Glutamine; Humans; Melanoma; Minor Histocompatibility Antigens; Neoplasms; Tumor Microenvironment; Ultrasonography

2023
Glutamine Influences Type-1 Conventional Dendritic Cell Antitumor Immunity.
    Cancer discovery, 2023, 09-06, Volume: 13, Issue:9

    Topics: CD8-Positive T-Lymphocytes; Dendritic Cells; Glutamine; Humans; Neoplasms

2023
Boosting the therapy of glutamine-addiction glioblastoma by combining glutamine metabolism therapy with photo-enhanced chemodynamic therapy.
    Biomaterials science, 2023, Sep-12, Volume: 11, Issue:18

    Topics: Cell Line, Tumor; Cell Membrane; Glioblastoma; Glucose; Glutamine; Glutathione; Humans; Hydrogen Peroxide; Nanoparticles; Neoplasms; Tumor Microenvironment

2023
Nursing care approaches to oral mucositis in pediatric oncology clinics: a cross-sectional study from Türkiye.
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2023, Sep-05, Volume: 31, Issue:10

    Topics: Benzydamine; Child; Chlorhexidine; Cross-Sectional Studies; Glutamine; Humans; Mucositis; Neoplasms; Stomatitis

2023
L-glutamine supplementation reduced morphological damage in the renal glomerulus of rats with Walker-256 tumor.
    Acta cirurgica brasileira, 2023, Volume: 38

    Topics: Animals; Cachexia; Collagen; Dietary Supplements; Fibroblast Growth Factor 2; Glutamine; Neoplasms; Rats; Rats, Wistar

2023
Discovery of
    Journal of medicinal chemistry, 2023, Nov-23, Volume: 66, Issue:22

    Topics: Diazooxonorleucine; Esters; Glutamine; Humans; Neoplasms; Prodrugs

2023
Application of metabolomics technologies toward cancer prognosis and therapy.
    International review of cell and molecular biology, 2019, Volume: 347

    Topics: Animals; Biomarkers, Tumor; Glucose; Glutamine; Humans; Mass Spectrometry; Metabolic Networks and Pathways; Metabolome; Metabolomics; Neoplasms

2019
Causes and Consequences of A Glutamine Induced Normoxic HIF1 Activity for the Tumor Metabolism.
    International journal of molecular sciences, 2019, Sep-24, Volume: 20, Issue:19

    Topics: Acetylation; Ascorbic Acid; Carbonic Anhydrase IX; Cell Line, Tumor; Energy Metabolism; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glutamine; Glycolysis; High-Throughput Nucleotide Sequencing; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Neoplasms; Protein Stability; RNA, Small Interfering

2019
Metabolic Diversity in Human Non-Small Cell Lung Cancer Cells.
    Molecular cell, 2019, 12-05, Volume: 76, Issue:5

    Topics: Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Gas Chromatography-Mass Spectrometry; Gene Expression Regulation, Neoplastic; Glucose; Glutamine; Humans; Metabolic Networks and Pathways; Metabolome; Metabolomics; Neoplasms

2019
T cell flexibility points to a metabolic checkpoint for cancer therapy.
    Nature reviews. Immunology, 2020, Volume: 20, Issue:1

    Topics: Glutamine; Humans; Immunotherapy; Neoplasms; Programmed Cell Death 1 Receptor; T-Lymphocytes; Tumor Escape

2020
Acidosis-induced metabolic reprogramming in tumor cells enhances the anti-proliferative activity of the PDK inhibitor dichloroacetate.
    Cancer letters, 2020, 02-01, Volume: 470

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dichloroacetic Acid; Drug Synergism; Female; Glutaminase; Glutamine; Glycolysis; Humans; Hydrogen-Ion Concentration; Mice; Neoplasms; Pentose Phosphate Pathway; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Sulfides; Thiadiazoles; Xenograft Model Antitumor Assays

2020
Glutamine Skipping the Q into Mitochondria.
    Trends in molecular medicine, 2020, Volume: 26, Issue:1

    Topics: Amino Acid Transport System ASC; Animals; Cell Proliferation; Cytoplasm; Glutaminase; Glutamine; Humans; Mitochondria; Neoplasms

2020
A Variant of SLC1A5 Is a Mitochondrial Glutamine Transporter for Metabolic Reprogramming in Cancer Cells.
    Cell metabolism, 2020, 02-04, Volume: 31, Issue:2

    Topics: Amino Acid Transport System ASC; Animals; Basic Helix-Loop-Helix Transcription Factors; Cell Line, Tumor; Cellular Reprogramming; Female; Glutamine; Humans; Mice; Mice, Inbred BALB C; Minor Histocompatibility Antigens; Mitochondria; Neoplasms; Tumor Hypoxia

2020
Co-delivery of 2-Deoxyglucose and a glutamine metabolism inhibitor V9302 via a prodrug micellar formulation for synergistic targeting of metabolism in cancer.
    Acta biomaterialia, 2020, 03-15, Volume: 105

    Topics: Animals; Antineoplastic Agents; Cell Death; Cell Line, Tumor; Cell Proliferation; Deoxyglucose; Drug Liberation; Drug Synergism; Female; Glucose; Glutamine; Humans; Mice, Inbred BALB C; Micelles; Neoplasms; Polyethylene Glycols; Prodrugs; Tissue Distribution

2020
Inhibiting both proline biosynthesis and lipogenesis synergistically suppresses tumor growth.
    The Journal of experimental medicine, 2020, 03-02, Volume: 217, Issue:3

    Topics: A549 Cells; Animals; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Female; Glutamine; HeLa Cells; Hep G2 Cells; Humans; Lipogenesis; MCF-7 Cells; Metabolic Networks and Pathways; Mice; Mice, Nude; Neoplasms; Proline

2020
Tumor Microenvironment, Metabolism, and Immunotherapy.
    The New England journal of medicine, 2020, 02-27, Volume: 382, Issue:9

    Topics: Animals; Azo Compounds; Caproates; Glutamine; Humans; Immunotherapy; Mice; Neoplasms; T-Lymphocytes; Tumor Microenvironment

2020
Aspirin Mitigated Tumor Growth in Obese Mice Involving Metabolic Inhibition.
    Cells, 2020, 02-28, Volume: 9, Issue:3

    Topics: Animals; Aspirin; Carcinoma, Lewis Lung; Cell Line, Tumor; Cell Movement; Cell Proliferation; Diet, High-Fat; Feeding Behavior; Glucose; Glutamine; Leukocytes; Male; Mice, Inbred C57BL; Mice, Obese; Neoplasms

2020
A shift in glutamine nitrogen metabolism contributes to the malignant progression of cancer.
    Nature communications, 2020, 03-17, Volume: 11, Issue:1

    Topics: Amidophosphoribosyltransferase; Animals; Biosynthetic Pathways; Cell Line, Tumor; Disease Progression; Gene Expression Regulation, Neoplastic; Glutaminase; Glutamine; Humans; Metabolomics; Mice, Nude; Models, Biological; Molecular Targeted Therapy; Neoplasms; Nitrogen; Prognosis

2020
Starvation and antimetabolic therapy promote cytokine release and recruitment of immune cells.
    Proceedings of the National Academy of Sciences of the United States of America, 2020, 05-05, Volume: 117, Issue:18

    Topics: Activating Transcription Factor 4; Antimetabolites; Cell Death; Deoxyglucose; Epithelial Cells; Gene Expression Regulation; Glucose; Glutamine; HeLa Cells; Humans; Inflammation; Interleukin-6; Interleukin-8; Macrophages; Metformin; Neoplasms; NF-kappa B; Promoter Regions, Genetic; Starvation; Stress, Physiological

2020
Metabolic Reprogramming in Health and Disease.
    International journal of molecular sciences, 2020, Apr-16, Volume: 21, Issue:8

    Topics: Cellular Reprogramming; Glutamine; Glycolysis; Humans; Lipid Metabolism; Mitochondria; Neoplasms

2020
The heterocyclic compound Tempol inhibits the growth of cancer cells by interfering with glutamine metabolism.
    Cell death & disease, 2020, 05-04, Volume: 11, Issue:5

    Topics: Animals; Cell Line, Tumor; Cell Proliferation; Cyclic N-Oxides; Female; Glutamine; Glycolysis; Heterocyclic Compounds; Humans; Isocitrate Dehydrogenase; Isocitrates; Ketoglutaric Acids; Mice, Inbred BALB C; Mice, Nude; Mitochondria; Molecular Docking Simulation; NAD; Neoplasms; Oxidative Phosphorylation; Pyruvic Acid; Reactive Oxygen Species; Serine; Spin Labels; Xenograft Model Antitumor Assays

2020
[Effects of dynamic nutrition support on energy metabolism, immune function and stress response after oral and maxillofacial tumor surgery].
    Shanghai kou qiang yi xue = Shanghai journal of stomatology, 2020, Volume: 29, Issue:1

    Topics: Energy Metabolism; Enteral Nutrition; Glutamine; Humans; Neoplasms; Postoperative Period

2020
Glutamine deprivation alters the origin and function of cancer cell exosomes.
    The EMBO journal, 2020, 08-17, Volume: 39, Issue:16

    Topics: Animals; Cell Proliferation; Drosophila melanogaster; Drosophila Proteins; Exosomes; Glutamine; MAP Kinase Signaling System; Mechanistic Target of Rapamycin Complex 1; Neoplasms; rab GTP-Binding Proteins

2020
Extracellular vesicles: eat glutamine and spit acidic bubbles.
    The EMBO journal, 2020, 08-17, Volume: 39, Issue:16

    Topics: Cell Communication; Exosomes; Extracellular Vesicles; Glutamine; Neoplasms; Signal Transduction

2020
Metabolic reprogramming sustains cancer cell survival following extracellular matrix detachment.
    Redox biology, 2020, Volume: 36

    Topics: Cell Survival; Extracellular Matrix; Glutamine; Glycolysis; Humans; Neoplasms

2020
Targeting glutamine metabolism as an effective means to promote allograft acceptance while inhibit tumor growth.
    Transplant immunology, 2020, Volume: 63

    Topics: Allografts; Animals; Antineoplastic Agents; Cell Growth Processes; Cell Line, Tumor; Glutamine; Graft Rejection; Graft Survival; Growth Inhibitors; Humans; Immune Tolerance; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Molecular Targeted Therapy; Neoplasms; Transplantation, Homologous

2020
Inhibition of Glutamine Utilization Synergizes with Immune Checkpoint Inhibitor to Promote Antitumor Immunity.
    Molecular cell, 2020, 11-19, Volume: 80, Issue:4

    Topics: Aged; Animals; Antibodies, Monoclonal; Apoptosis; B7-H1 Antigen; Cell Proliferation; Female; Glutamine; Glutathione; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Nude; Neoplasms; Sarcoplasmic Reticulum Calcium-Transporting ATPases; T-Lymphocytes; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2020
Targeting Glutamine Metabolism and PD-L1: A Novel Anti-tumor Pas de Deux.
    Molecular cell, 2020, 11-19, Volume: 80, Issue:4

    Topics: B7-H1 Antigen; Glutamine; Humans; Neoplasms; NF-kappa B

2020
Time-resolved non-invasive metabolomic monitoring of a single cancer spheroid by microfluidic NMR.
    Scientific reports, 2021, 01-08, Volume: 11, Issue:1

    Topics: Alanine; Glucose; Glutamine; Humans; Hydrogen-Ion Concentration; Lab-On-A-Chip Devices; Lactic Acid; Magnetic Resonance Spectroscopy; MCF-7 Cells; Metabolomics; Microfluidic Analytical Techniques; Neoplasms; Spheroids, Cellular

2021
Cell-programmed nutrient partitioning in the tumour microenvironment.
    Nature, 2021, Volume: 593, Issue:7858

    Topics: Animals; Carcinoma, Renal Cell; Cell Line, Tumor; Female; Glucose; Glutamine; Humans; Lipid Metabolism; Male; Mechanistic Target of Rapamycin Complex 1; Mice; Myeloid Cells; Neoplasms; Nutrients; Tumor Microenvironment

2021
Glutamine Metabolism in Cancer.
    Advances in experimental medicine and biology, 2021, Volume: 1311

    Topics: Citric Acid Cycle; Energy Metabolism; Glutamine; Glycolysis; Humans; Metabolic Networks and Pathways; Neoplasms

2021
Bridging the Metabolic Parallels Between Neurological Diseases and Cancer.
    Advances in experimental medicine and biology, 2021, Volume: 1311

    Topics: Dipeptides; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Neoplasms; Organophosphorus Compounds

2021
Metabolic Intersection of Cancer and Cardiovascular Diseases: Opportunities for Cancer Therapy.
    Advances in experimental medicine and biology, 2021, Volume: 1311

    Topics: Cardiovascular Diseases; Glutamic Acid; Glutaminase; Glutamine; Humans; Neoplasms

2021
Can tumor cells take it all away?
    Cell metabolism, 2021, 06-01, Volume: 33, Issue:6

    Topics: Cell Proliferation; Citric Acid Cycle; Glucose; Glutamine; Glycolysis; Humans; Neoplasms

2021
DDIT3 Directs a Dual Mechanism to Balance Glycolysis and Oxidative Phosphorylation during Glutamine Deprivation.
    Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2021, Volume: 8, Issue:11

    Topics: Animals; Apoptosis Regulatory Proteins; Electron Transport Complex IV; Energy Metabolism; Gene Expression Regulation, Neoplastic; Glutamine; Glycolysis; HCT116 Cells; Humans; Mice; Mice, Knockout; Neoplasms; Oxidative Phosphorylation; Phosphoric Monoester Hydrolases; Transcription Factor CHOP; Ubiquinone

2021
The GAS6-AXL signaling pathway triggers actin remodeling that drives membrane ruffling, macropinocytosis, and cancer-cell invasion.
    Proceedings of the National Academy of Sciences of the United States of America, 2021, 07-13, Volume: 118, Issue:28

    Topics: Actin Cytoskeleton; Actins; Axl Receptor Tyrosine Kinase; Cell Line, Tumor; Cell Proliferation; Cell Surface Extensions; Enzyme Activation; Focal Adhesions; Glioblastoma; Glutamine; HEK293 Cells; Humans; Intercellular Signaling Peptides and Proteins; Models, Biological; Neoplasm Invasiveness; Neoplasms; Phosphatidylinositol 3-Kinases; Pinocytosis; Protein Binding; Proto-Oncogene Proteins; rac1 GTP-Binding Protein; Receptor Protein-Tyrosine Kinases; Signal Transduction

2021
Is glucose the scapegoat for tumor evasion?
    Cancer cell, 2021, 07-12, Volume: 39, Issue:7

    Topics: Glucose; Glutamine; Glycolysis; Humans; Neoplasms; Tumor Microenvironment

2021
Lactate and glutamine support NADPH generation in cancer cells under glucose deprived conditions.
    Redox biology, 2021, Volume: 46

    Topics: Animals; Glucose; Glutamine; Lactic Acid; Mice; NADP; Neoplasms; Pentose Phosphate Pathway

2021
Back to the Future: Therapeutic Targeting of Cancer Cell Metabolism.
    SLAS discovery : advancing life sciences R & D, 2017, Volume: 22, Issue:4

    Topics: Antineoplastic Agents; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Glucose; Glutamine; Glycolysis; Humans; Molecular Targeted Therapy; Neoplasm Proteins; Neoplasms; Oncogenes; Oxidative Phosphorylation; Serine

2017
SNAT7 is the primary lysosomal glutamine exporter required for extracellular protein-dependent growth of cancer cells.
    Proceedings of the National Academy of Sciences of the United States of America, 2017, 05-02, Volume: 114, Issue:18

    Topics: Amino Acid Transport Systems, Neutral; Glutamine; HeLa Cells; Humans; Intracellular Membranes; Lysosomes; Neoplasm Proteins; Neoplasms; Tumor Microenvironment

2017
Kr-POK (ZBTB7c) regulates cancer cell proliferation through glutamine metabolism.
    Biochimica et biophysica acta. Gene regulatory mechanisms, 2017, Volume: 1860, Issue:8

    Topics: Animals; Cell Death; Cell Line; Cell Proliferation; Gene Expression Regulation, Neoplastic; Glutaminase; Glutamine; HEK293 Cells; Humans; Intracellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms; Proteins; RNA, Small Interfering; STAT1 Transcription Factor; Transcription Factors; Transcription, Genetic

2017
A Critical Role of Glutamine and Asparagine γ-Nitrogen in Nucleotide Biosynthesis in Cancer Cells Hijacked by an Oncogenic Virus.
    mBio, 2017, 08-15, Volume: 8, Issue:4

    Topics: Asparagine; Aspartate Aminotransferases; Aspartic Acid; Cell Proliferation; Glutamate Dehydrogenase; Glutamic Acid; Glutaminase; Glutamine; Herpesvirus 8, Human; Humans; Metabolic Networks and Pathways; Neoplasms; Nitrogen; Nucleotides

2017
A metabolic core model elucidates how enhanced utilization of glucose and glutamine, with enhanced glutamine-dependent lactate production, promotes cancer cell growth: The WarburQ effect.
    PLoS computational biology, 2017, Volume: 13, Issue:9

    Topics: Animals; Cell Proliferation; Computer Simulation; Glucose; Glutamine; Humans; Lactic Acid; Metabolic Flux Analysis; Metabolic Networks and Pathways; Models, Biological; Neoplasms

2017
    Molecular systems biology, 2017, 10-04, Volume: 13, Issue:10

    Topics: Cell Line, Tumor; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Glutamine; HCT116 Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; MCF-7 Cells; Metabolomics; Neoplasms; Piperazines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-myc; Pyridines; TOR Serine-Threonine Kinases

2017
Systematic analyses of glutamine and glutamate metabolisms across different cancer types.
    Chinese journal of cancer, 2017, Nov-07, Volume: 36, Issue:1

    Topics: Gene Expression Regulation, Neoplastic; Glutamic Acid; Glutamine; Humans; Neoplasms

2017
Dietary glutamine, glutamate and mortality: two large prospective studies in US men and women.
    International journal of epidemiology, 2018, 02-01, Volume: 47, Issue:1

    Topics: Adult; Aged; Cardiovascular Diseases; Dietary Supplements; Female; Follow-Up Studies; Glutamic Acid; Glutamine; Humans; Life Style; Male; Middle Aged; Neoplasms; Prospective Studies; Risk Factors; United States

2018
Structural characterisation reveals insights into substrate recognition by the glutamine transporter ASCT2/SLC1A5.
    Nature communications, 2018, 01-02, Volume: 9, Issue:1

    Topics: Amino Acid Sequence; Amino Acid Transport System ASC; Amino Acids; Animals; Binding Sites; Escherichia coli; Glutamine; Mutagenesis, Site-Directed; Neoplasms; Oocytes; Patch-Clamp Techniques; Protein Structure, Tertiary; Substrate Specificity; Xenopus laevis

2018
Glutamine-derived 2-hydroxyglutarate is associated with disease progression in plasma cell malignancies.
    JCI insight, 2018, 01-11, Volume: 3, Issue:1

    Topics: Biomarkers, Tumor; Cell Line, Tumor; Citric Acid Cycle; Disease Progression; DNA-Binding Proteins; Glucose; Glutamine; Glutarates; Glycolysis; Humans; Lactic Acid; Multiple Myeloma; Multivariate Analysis; Neoplasms; Plasma Cells; Transcription Factors

2018
Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models.
    Nature medicine, 2018, Volume: 24, Issue:2

    Topics: Amino Acid Transport System ASC; Animals; Cell Line, Tumor; Cell Proliferation; Computer Simulation; Disease Models, Animal; Glutamine; HCT116 Cells; Humans; Mice; Minor Histocompatibility Antigens; Neoplasms; Oxidative Stress; Signal Transduction; Small Molecule Libraries

2018
CHTM1, a novel metabolic marker deregulated in human malignancies.
    Oncogene, 2018, Volume: 37, Issue:15

    Topics: Base Sequence; Biomarkers, Tumor; Carcinogenesis; Cytosol; Energy Metabolism; Glucose; Glutamine; HEK293 Cells; Humans; Lipid Metabolism; MCF-7 Cells; Membrane Proteins; Mitochondria; Mitochondrial Proteins; Neoplasms; Nutrients; Signal Transduction; Tumor Cells, Cultured

2018
[Effect of Oral Glutamine on Chemotherapy-Induced Peripheral Neuropathy in Cancer Patients: An Evidence-Based Appraisal].
    Hu li za zhi The journal of nursing, 2018, Volume: 65, Issue:1

    Topics: Administration, Oral; Antineoplastic Agents; Evidence-Based Nursing; Glutamine; Humans; Neoplasms; Peripheral Nervous System Diseases

2018
Rational cell culture optimization enhances experimental reproducibility in cancer cells.
    Scientific reports, 2018, 02-14, Volume: 8, Issue:1

    Topics: Animals; Cell Culture Techniques; Cell Line, Tumor; Cell Proliferation; Glutaminase; Glutamine; Humans; Metabolomics; Neoplasms; Reproducibility of Results; Research Design; Thiadiazoles

2018
Inhibition of mTOR complexes protects cancer cells from glutamine starvation induced cell death by restoring Akt stability.
    Biochimica et biophysica acta. Molecular basis of disease, 2018, Volume: 1864, Issue:6 Pt A

    Topics: Animals; Apoptosis; Autophagy; Cell Line, Tumor; Cell Survival; Glutamine; Humans; Mice; Neoplasms; NIH 3T3 Cells; Protein Kinase Inhibitors; Protein Stability; Proteolysis; Proto-Oncogene Proteins c-akt; TOR Serine-Threonine Kinases; Ubiquitination

2018
Accelerated lipid catabolism and autophagy are cancer survival mechanisms under inhibited glutaminolysis.
    Cancer letters, 2018, 08-28, Volume: 430

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Benzophenanthridines; Cell Line, Tumor; Cell Proliferation; Chloroquine; Glutaminase; Glutamine; Humans; Lipolysis; Metabolomics; Neoplasms; Oxidative Stress

2018
The glycerol backbone of phospholipids derives from noncarbohydrate precursors in starved lung cancer cells.
    Proceedings of the National Academy of Sciences of the United States of America, 2018, 06-12, Volume: 115, Issue:24

    Topics: A549 Cells; Animals; Glucose; Glutamine; Glycerol; Heterografts; Humans; Lactic Acid; Male; Mice; Mice, Nude; Neoplasms; Phosphoenolpyruvate Carboxykinase (ATP); Phospholipids

2018
Antineoplastons: when is enough enough?
    The Lancet. Oncology, 2018, Volume: 19, Issue:6

    Topics: Administration, Intravenous; Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Evidence-Based Medicine; Glutamine; Humans; Neoplasms; Neurotoxicity Syndromes; Patient Safety; Phenylacetates; Quackery; Risk Assessment; Treatment Outcome

2018
A hypothetical method for controlling highly glycolytic cancers and metastases.
    Medical hypotheses, 2018, Volume: 118

    Topics: Blood Glucose; Cell Proliferation; Cerebrovascular Circulation; Deoxyglucose; Diet, Ketogenic; Glutamine; Glycolysis; Humans; Hypoglycemia; Hypoglycemic Agents; Insulin; Models, Theoretical; Neoplasm Metastasis; Neoplasms

2018
A Role for p53 in the Adaptation to Glutamine Starvation through the Expression of SLC1A3.
    Cell metabolism, 2018, 11-06, Volume: 28, Issue:5

    Topics: Adaptation, Physiological; Animals; Cell Line, Tumor; Cell Survival; Citric Acid Cycle; Excitatory Amino Acid Transporter 1; Female; Glutamine; Humans; Mice, Inbred BALB C; Neoplasms; Starvation; Tumor Suppressor Protein p53

2018
Cytosolic Aspartate Availability Determines Cell Survival When Glutamine Is Limiting.
    Cell metabolism, 2018, 11-06, Volume: 28, Issue:5

    Topics: Amino Acid Transport Systems, Acidic; Animals; Antiporters; Aspartic Acid; Cell Line; Cell Proliferation; Cell Survival; Citric Acid Cycle; Cytosol; Female; Glutamine; Humans; Mice, Inbred C57BL; Mitochondria; Neoplasms

2018
Theanine, an antitumor promoter, induces apoptosis of tumor cells via the mitochondrial pathway.
    Molecular medicine reports, 2018, Volume: 18, Issue:5

    Topics: Apoptosis; Caspase 3; Caspase 8; Cell Proliferation; Cytochromes c; DNA Damage; Gene Expression Regulation, Neoplastic; Glutamates; Glutamine; HEK293 Cells; HeLa Cells; Hep G2 Cells; Humans; Membrane Potential, Mitochondrial; Mitochondria; Neoplasms; Signal Transduction; Tea

2018
Multi-scale computational study of the Warburg effect, reverse Warburg effect and glutamine addiction in solid tumors.
    PLoS computational biology, 2018, Volume: 14, Issue:12

    Topics: Cell Line, Tumor; Cell Proliferation; Citric Acid Cycle; Glucose; Glutamine; Glycolysis; Humans; Kinetics; Lactic Acid; Metabolic Networks and Pathways; Metabolome; Neoplasms; Oxygen; Tumor Microenvironment

2018
Acid-Induced Downregulation of ASS1 Contributes to the Maintenance of Intracellular pH in Cancer.
    Cancer research, 2019, 02-01, Volume: 79, Issue:3

    Topics: Adolescent; Adult; Animals; Argininosuccinate Synthase; Bone Neoplasms; Cell Hypoxia; Cell Line, Tumor; Cell Movement; Child; Down-Regulation; Gene Expression Profiling; Glutamine; Humans; Hydrogen-Ion Concentration; Male; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Mice, SCID; Neoplasms; Osteosarcoma; Oxidation-Reduction; Young Adult

2019
Coordinative metabolism of glutamine carbon and nitrogen in proliferating cancer cells under hypoxia.
    Nature communications, 2019, 01-14, Volume: 10, Issue:1

    Topics: Acetyl Coenzyme A; Ammonia; Animals; Carbon; Cell Hypoxia; Cell Line, Tumor; Cell Survival; Female; Glucose; Glutamine; HEK293 Cells; Humans; Lactic Acid; Lipogenesis; Metabolic Networks and Pathways; Metabolome; Metabolomics; Mice; Mice, Nude; Neoplasms; Nitrogen; Nucleotides; Orotic Acid; Tumor Microenvironment; Xenograft Model Antitumor Assays

2019
γ-Glutamyltransferase enzyme activity of cancer cells modulates L-γ-glutamyl-p-nitroanilide (GPNA) cytotoxicity.
    Scientific reports, 2019, 01-29, Volume: 9, Issue:1

    Topics: Acetylcysteine; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Survival; Enzyme Activation; gamma-Glutamyltransferase; Glutamine; Humans; Hydrolysis; Metabolic Detoxication, Phase I; Neoplasms; Reactive Oxygen Species

2019
Overview of Glutamine Dependency and Metabolic Rescue Protocols.
    Methods in molecular biology (Clifton, N.J.), 2019, Volume: 1928

    Topics: Adaptation, Biological; Cell Culture Techniques; Cell Line, Tumor; Cell Proliferation; Endoplasmic Reticulum Stress; Energy Metabolism; Gene Expression Regulation, Neoplastic; Glucose; Glutamine; Glycolysis; Humans; Metabolic Networks and Pathways; Neoplasms; Oxygen; Signal Transduction

2019
HIF1α Suppresses Tumor Cell Proliferation through Inhibition of Aspartate Biosynthesis.
    Cell reports, 2019, 02-26, Volume: 26, Issue:9

    Topics: Adult; Aged; Aged, 80 and over; Aspartate Aminotransferase, Cytoplasmic; Aspartate Aminotransferase, Mitochondrial; Aspartic Acid; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Proliferation; Female; Glutamine; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Kidney Neoplasms; Male; Middle Aged; Mitochondrial Proteins; Neoplasms; Oxidation-Reduction; Tumor Suppressor Proteins; Von Hippel-Lindau Tumor Suppressor Protein

2019
Enhanced metabolic activities for ATP production and elevated metabolic flux via pentose phosphate pathway contribute for better CIK cells expansion.
    Cell proliferation, 2019, Volume: 52, Issue:3

    Topics: Adenosine Triphosphate; Cell Culture Techniques; Cell Proliferation; Cytokine-Induced Killer Cells; Fetal Blood; Glucose; Glucose Transporter Type 1; Glutamine; Glycolysis; Humans; Immunotherapy, Adoptive; Models, Biological; Neoplasms; Oxygen Consumption; Pentose Phosphate Pathway

2019
Synthesis and preliminary evaluation of a novel glutamine derivative: (2S,4S)4-[
    Bioorganic & medicinal chemistry letters, 2019, 05-01, Volume: 29, Issue:9

    Topics: Apoptosis Regulatory Proteins; Cell Line, Tumor; Crown Ethers; Fluorine Radioisotopes; Glutamine; Humans; Neoplasms; Radiopharmaceuticals; Ribonucleoproteins

2019
Deprivation of glutamine in cell culture reveals its potential for treating cancer.
    Proceedings of the National Academy of Sciences of the United States of America, 2019, 04-02, Volume: 116, Issue:14

    Topics: Animals; BALB 3T3 Cells; Cell Culture Techniques; Cell Transformation, Neoplastic; Culture Media; Glutamine; Mice; Neoplasms

2019
Spatial-fluxomics provides a subcellular-compartmentalized view of reductive glutamine metabolism in cancer cells.
    Nature communications, 2019, 03-22, Volume: 10, Issue:1

    Topics: Animals; Carbon Isotopes; Cell Compartmentation; Cell Hypoxia; Citrate (si)-Synthase; Citric Acid; Citric Acid Cycle; Cytosol; Glutamine; HeLa Cells; Humans; Isocitrate Dehydrogenase; Metabolic Flux Analysis; Metabolome; Mice; Mitochondria; Neoplasms; Subcellular Fractions; Succinate Dehydrogenase

2019
BAG3 promotes autophagy and glutaminolysis via stabilizing glutaminase.
    Cell death & disease, 2019, 03-25, Volume: 10, Issue:4

    Topics: Adaptor Proteins, Signal Transducing; Ammonia; Apoptosis Regulatory Proteins; Autophagy; Enzyme Stability; Glutaminase; Glutamine; Hep G2 Cells; Humans; MCF-7 Cells; Mitochondria; Neoplasms; Proteasome Endopeptidase Complex; Proteolysis; Sirtuins; Transfection; Ubiquitination

2019
Inhibition of Glucose Transporters and Glutaminase Synergistically Impairs Tumor Cell Growth.
    Cell chemical biology, 2019, 09-19, Volume: 26, Issue:9

    Topics: Benzeneacetamides; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Citric Acid Cycle; Female; Glucose; Glucose Transport Proteins, Facilitative; Glucose Transporter Type 1; Glucose Transporter Type 3; Glutaminase; Glutamine; Glycolysis; Humans; Male; Neoplasms; Thiadiazoles

2019
Glutamine Synthetase Promotes Radiation Resistance via Facilitating Nucleotide Metabolism and Subsequent DNA Damage Repair.
    Cell reports, 2019, 07-30, Volume: 28, Issue:5

    Topics: Animals; Cell Line, Tumor; DNA Damage; DNA Repair; Glutamate-Ammonia Ligase; Glutamine; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Proteins; Neoplasms; Nucleotides; Radiation Tolerance

2019
Immunosuppressive Immature Myeloid Cell Generation Is Controlled by Glutamine Metabolism in Human Cancer.
    Cancer immunology research, 2019, Volume: 7, Issue:10

    Topics: Animals; Antigen Presentation; B7-H1 Antigen; Cell Line, Tumor; Cell Proliferation; Female; Glutamine; Glycolysis; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Immunosuppressive Agents; Mice; Mice, Inbred BALB C; Myeloid Cells; Neoplasms; Signal Transduction; T-Lymphocytes; Tumor Microenvironment

2019
The axis of MAPK1/3-XBP1u-FOXO1 controls autophagic dynamics in cancer cells.
    Autophagy, 2013, Volume: 9, Issue:5

    Topics: Autophagy; DNA-Binding Proteins; Extracellular Signal-Regulated MAP Kinases; Forkhead Transcription Factors; Glutamine; HCT116 Cells; Humans; Models, Biological; Neoplasms; Phosphorylation; Proteolysis; Regulatory Factor X Transcription Factors; Signal Transduction; Transcription Factors

2013
Cancer control via glucose and glutamine deprivation.
    Journal of internal medicine, 2013, Volume: 274, Issue:5

    Topics: Endothelium, Vascular; Glucose; Glutamine; Humans; Lactic Acid; Neoplasms; Neovascularization, Pathologic

2013
The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4.
    Cell, 2013, May-09, Volume: 153, Issue:4

    Topics: Activating Transcription Factors; Animals; Cell Proliferation; Embryo, Mammalian; Energy Metabolism; Glutamate Dehydrogenase; Glutamine; Humans; Mechanistic Target of Rapamycin Complex 1; Mice; Mitochondrial Proteins; Multiprotein Complexes; Neoplasm Transplantation; Neoplasms; Sirtuins; TOR Serine-Threonine Kinases; Transcription, Genetic; Transplantation, Heterologous; Tuberous Sclerosis Complex 2 Protein; Tumor Suppressor Proteins; Ubiquitination

2013
Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids.
    Proceedings of the National Academy of Sciences of the United States of America, 2013, May-28, Volume: 110, Issue:22

    Topics: Animals; Autophagy; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Carbon Isotopes; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Fatty Acids; Glucose; Glutamine; Humans; Lipogenesis; Mice; Mice, Knockout; Neoplasms; Oxygen Consumption; Phospholipids; Pinocytosis; ras Proteins; Stearoyl-CoA Desaturase

2013
Metabolism: Metabolic block.
    Nature reviews. Cancer, 2013, Volume: 13, Issue:7

    Topics: Animals; DNA Damage; Female; Glutamine; Humans; Male; Mitochondria; Mitochondrial Proteins; Neoplasms; Neoplasms, Experimental; Sirtuins

2013
Cancer metabolism in breadth and depth.
    Nature biotechnology, 2013, Volume: 31, Issue:6

    Topics: Animals; Benzeneacetamides; Cell Differentiation; Cell Transformation, Neoplastic; Enzyme Inhibitors; Glioma; Glutamine; Hematopoiesis; Humans; Imidazoles; Isocitrate Dehydrogenase; Leukemia, Myeloid, Acute; Metabolic Networks and Pathways; Neoplasms; Oncogene Protein p21(ras); Pancreatic Neoplasms; Phenylurea Compounds; Proto-Oncogene Proteins; ras Proteins; Sulfonamides

2013
Synthesis and radiolabelling of DOTA-linked glutamine analogues with ⁶⁷,⁶⁸Ga as markers for increased glutamine metabolism in tumour cells.
    Molecules (Basel, Switzerland), 2013, Jun-19, Volume: 18, Issue:6

    Topics: Biomarkers; Cell Line, Tumor; Gallium Radioisotopes; Glutamine; Heterocyclic Compounds, 1-Ring; Humans; Isotope Labeling; Neoplasms; Positron-Emission Tomography; Radioactive Tracers; Radiopharmaceuticals

2013
Availability of the key metabolic substrates dictates the respiratory response of cancer cells to the mitochondrial uncoupling.
    Biochimica et biophysica acta, 2014, Volume: 1837, Issue:1

    Topics: Animals; Apoptosis; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cell Respiration; Energy Metabolism; Galactose; Glucose; Glutamine; Glycolysis; HCT116 Cells; Humans; Mice; Mitochondria; Neoplasms; Oxidative Phosphorylation; Oxygen Consumption; PC12 Cells; Pyruvic Acid; Rats; Substrate Specificity

2014
MYC, metabolism, cell growth, and tumorigenesis.
    Cold Spring Harbor perspectives in medicine, 2013, Aug-01, Volume: 3, Issue:8

    Topics: Carcinogenesis; Cell Transformation, Neoplastic; Gene Expression Regulation, Neoplastic; Genes, myc; Genes, p53; Glucose; Glutamine; Humans; Lipid Metabolism; Mitochondria; Neoplasms; Proto-Oncogene Mas; Proto-Oncogene Proteins c-myc; Ribosomes; Signal Transduction; Transcription Factors

2013
Elevated phenylacetic acid levels do not correlate with adverse events in patients with urea cycle disorders or hepatic encephalopathy and can be predicted based on the plasma PAA to PAGN ratio.
    Molecular genetics and metabolism, 2013, Volume: 110, Issue:4

    Topics: Biomarkers; Drug-Related Side Effects and Adverse Reactions; Glutamine; Glycerol; Hepatic Encephalopathy; Humans; Liver; Neoplasms; Phenylacetates; Phenylbutyrates; Randomized Controlled Trials as Topic; Urea Cycle Disorders, Inborn

2013
[Leucine sensing in the regulation of autophagy: glutamate dehydrogenase is on the way].
    Medecine sciences : M/S, 2013, Volume: 29, Issue:10

    Topics: Autophagy; Glutamate Dehydrogenase; Glutamine; Humans; Leucine; Mechanistic Target of Rapamycin Complex 1; Models, Biological; Multiprotein Complexes; Neoplasms; Reactive Oxygen Species; Signal Transduction; TOR Serine-Threonine Kinases

2013
Hexokinase 2 as oncotarget.
    Oncotarget, 2013, Volume: 4, Issue:11

    Topics: Animals; Glucose; Glutamine; Hexokinase; Humans; Mice; Molecular Targeted Therapy; Neoplasms

2013
Glutamine-driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia.
    Molecular systems biology, 2013, Dec-03, Volume: 9

    Topics: Adenosine Triphosphate; Animals; Cell Hypoxia; Cell Line, Transformed; Cell Line, Tumor; Glutamine; Humans; Metabolic Networks and Pathways; Mice; Models, Biological; Neoplasms; Oxidative Phosphorylation; Systems Biology

2013
[Efficacy of AboundTM for hand-foot syndrome caused by capecitabine].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2013, Volume: 40, Issue:12

    Topics: Aged; Antimetabolites, Antineoplastic; Arginine; Butyrates; Capecitabine; Deoxycytidine; Female; Fluorouracil; Glutamine; Hand-Foot Syndrome; Humans; Hydroxy Acids; Male; Middle Aged; Neoplasms

2013
The many faces of sirtuins: Sirtuins and the Warburg effect.
    Nature medicine, 2014, Volume: 20, Issue:1

    Topics: Antineoplastic Agents; Glutamine; Glycolysis; Humans; Longevity; Metabolic Networks and Pathways; Models, Biological; NAD; Neoplasms; Sirtuins

2014
Transient state microscopy probes patterns of altered oxygen consumption in cancer cells.
    The FEBS journal, 2014, Volume: 281, Issue:5

    Topics: Breast Neoplasms; Cell Line, Tumor; Eosine Yellowish-(YS); Female; Fluorescent Dyes; Glucose; Glutamine; Glycolysis; Humans; MCF-7 Cells; Metabolic Networks and Pathways; Microscopy, Fluorescence; Neoplasms; Oxidative Phosphorylation; Oxygen Consumption

2014
Stable isotope imaging of biological samples with high resolution secondary ion mass spectrometry and complementary techniques.
    Methods (San Diego, Calif.), 2014, Jul-01, Volume: 68, Issue:2

    Topics: Antimicrobial Cationic Peptides; Cell Line, Tumor; Cell Membrane; Glutamine; Humans; Isotope Labeling; Lipoproteins; Microscopy, Atomic Force; Nanotechnology; Neoplasms; Spectrometry, Mass, Secondary Ion; Tissue Distribution

2014
13C isotope-assisted methods for quantifying glutamine metabolism in cancer cells.
    Methods in enzymology, 2014, Volume: 542

    Topics: Biochemistry; Carbon Isotopes; Cell Hypoxia; Cells, Cultured; Gas Chromatography-Mass Spectrometry; Glutamic Acid; Glutamine; Humans; Lipids; Neoplasms

2014
Blocking anaplerotic entry of glutamine into the TCA cycle sensitizes K-Ras mutant cancer cells to cytotoxic drugs.
    Oncogene, 2015, May-14, Volume: 34, Issue:20

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Capecitabine; Cell Cycle Checkpoints; Cell Line, Tumor; Citric Acid Cycle; Cytotoxins; Deoxycytidine; Fluorouracil; Glutamine; Humans; Mutation; Neoplasms; Paclitaxel; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); ras Proteins

2015
The SIRT1/HIF2α axis drives reductive glutamine metabolism under chronic acidosis and alters tumor response to therapy.
    Cancer research, 2014, Oct-01, Volume: 74, Issue:19

    Topics: Acidosis; Basic Helix-Loop-Helix Transcription Factors; Cell Line, Tumor; Chronic Disease; Glucose; Glutamine; Glycolysis; Humans; Neoplasms; Sirtuin 1

2014
Gln-362 of angiopoietin-2 mediates migration of tumor and endothelial cells through association with α5β1 integrin.
    The Journal of biological chemistry, 2014, Nov-07, Volume: 289, Issue:45

    Topics: Angiopoietin-2; Animals; Cell Adhesion; Cell Line, Tumor; Cell Movement; CHO Cells; Cricetinae; Cricetulus; Endothelial Cells; Gene Expression Regulation; Glutamine; Humans; Integrin alpha5beta1; Integrins; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasms; Neovascularization, Pathologic; Plasmids; Protein Structure, Tertiary; Receptor, TIE-2

2014
Asparagine protects tumor cells from glutamine depletion-induced cell death.
    Cancer discovery, 2014, Volume: 4, Issue:11

    Topics: Asparagine; Aspartate-Ammonia Ligase; Cell Death; Glutamine; Humans; Neoplasms; Transcription Factor CHOP

2014
Simultaneously targeting tissue transglutaminase and kidney type glutaminase sensitizes cancer cells to acid toxicity and offers new opportunities for therapeutic intervention.
    Molecular pharmaceutics, 2015, Jan-05, Volume: 12, Issue:1

    Topics: Allosteric Site; Ammonia; Antineoplastic Agents; Catalysis; Catalytic Domain; Cell Death; Cell Line, Tumor; Cell Proliferation; Drug Design; Drug Screening Assays, Antitumor; Glutamic Acid; Glutamine; GTP-Binding Proteins; Humans; Hydrogen-Ion Concentration; Inhibitory Concentration 50; Kidney; Neoplasm Metastasis; Neoplasms; Protein Glutamine gamma Glutamyltransferase 2; Transglutaminases

2015
Is glutamine deficiency the link between inflammation, malnutrition, and fatigue in cancer patients?
    Clinical nutrition (Edinburgh, Scotland), 2015, Volume: 34, Issue:6

    Topics: Adult; Aged; Biomarkers; Cross-Sectional Studies; Electric Impedance; Fatigue; Female; Glutamine; Humans; Inflammation; Male; Malnutrition; Middle Aged; Motor Activity; Neoplasms; Nutrition Assessment; Nutritional Status; Prognosis; Surveys and Questionnaires

2015
CtBP maintains cancer cell growth and metabolic homeostasis via regulating SIRT4.
    Cell death & disease, 2015, Jan-29, Volume: 6

    Topics: Alcohol Oxidoreductases; Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Respiration; DNA-Binding Proteins; Glutamine; Glycolysis; Homeostasis; Humans; Hydrogen-Ion Concentration; Methionine; Mice; Mice, Nude; Mitochondrial Proteins; Models, Biological; Neoplasms; Sirtuins; Xenograft Model Antitumor Assays

2015
Evolving paradigms in the nutritional support of critically ill surgical patients.
    Current problems in surgery, 2015, Volume: 52, Issue:4

    Topics: Arginine; Burns; Cachexia; Critical Illness; Enteral Nutrition; Fish Oils; Gastrointestinal Tract; Glutamine; Humans; Infusions, Intravenous; Lipids; Microbiota; Multiple Organ Failure; Muscle, Skeletal; Neoplasms; Parenteral Nutrition; Perioperative Care; Protein-Energy Malnutrition; Stress, Physiological

2015
Metabolic reprogramming as a continuous changing behavior of tumor cells.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2015, Volume: 36, Issue:8

    Topics: Acidosis; Cell Hypoxia; Cell Line, Tumor; Glucose; Glutamine; Glycolysis; Humans; Neoplasms; Tumor Microenvironment

2015
Mitochondrial Phosphoenolpyruvate Carboxykinase Regulates Metabolic Adaptation and Enables Glucose-Independent Tumor Growth.
    Molecular cell, 2015, Oct-15, Volume: 60, Issue:2

    Topics: Adaptation, Physiological; Animals; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Citric Acid Cycle; Gene Expression Regulation, Neoplastic; Gluconeogenesis; Glucose; Glutamine; Humans; Lung Neoplasms; Metabolomics; Mice; Mice, Nude; Mitochondria; Neoplasms; Phosphoenolpyruvate; Phosphoenolpyruvate Carboxykinase (ATP); Purines; Pyruvic Acid; Serine

2015
Linking Cancer Metabolism to DNA Repair and Accelerated Senescence.
    Molecular cancer research : MCR, 2016, Volume: 14, Issue:2

    Topics: Acetylglucosamine; Cellular Senescence; DNA; DNA Repair; Epigenesis, Genetic; Genomic Instability; Glutamine; Glycolysis; Humans; MCF-7 Cells; Neoplasms; RNA Interference

2016
Q-ing tumor glutaminase for therapy.
    Oncotarget, 2015, Nov-17, Volume: 6, Issue:36

    Topics: Animals; Enzyme Inhibitors; Glutaminase; Glutamine; Humans; Mice; Neoplasms

2015
Lactate promotes glutamine uptake and metabolism in oxidative cancer cells.
    Cell cycle (Georgetown, Tex.), 2016, Volume: 15, Issue:1

    Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Glutaminase; Glutamine; HeLa Cells; Humans; Lactic Acid; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Monocarboxylic Acid Transporters; Neoplasms; Oxidation-Reduction; Symporters

2016
Dlx-2 and glutaminase upregulate epithelial-mesenchymal transition and glycolytic switch.
    Oncotarget, 2016, Feb-16, Volume: 7, Issue:7

    Topics: Adenosine Triphosphate; Apoptosis; Blotting, Western; Cell Proliferation; Chromatin Immunoprecipitation; Epithelial-Mesenchymal Transition; Fluorescent Antibody Technique; Glutaminase; Glutamine; Glycolysis; HeLa Cells; Hep G2 Cells; Homeodomain Proteins; Humans; MCF-7 Cells; Neoplasms; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Snail Family Transcription Factors; Transcription Factors; Transforming Growth Factor beta; Tumor Cells, Cultured

2016
Protein Kinase A Activation Promotes Cancer Cell Resistance to Glucose Starvation and Anoikis.
    PLoS genetics, 2016, Volume: 12, Issue:3

    Topics: Animals; Anoikis; Autophagy; Cell Line, Tumor; Cell Survival; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Endoplasmic Reticulum Stress; Glucose; Glutamine; Glycolysis; Humans; Mice; Neoplasms; Starvation; Transcriptome

2016
Automated synthesis of [(18)F](2S,4R)-4-fluoroglutamine on a GE TRACERlab™ FX-N Pro module.
    Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 2016, Volume: 112

    Topics: Automation; Chemistry Techniques, Synthetic; Drug Stability; Fluorine Radioisotopes; Glutamine; Humans; Neoplasms; Positron-Emission Tomography; Radiopharmaceuticals; Technology, Radiologic

2016
Reductive carboxylation supports redox homeostasis during anchorage-independent growth.
    Nature, 2016, Apr-14, Volume: 532, Issue:7598

    Topics: Cell Adhesion; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Citric Acid; Contact Inhibition; Cytosol; Extracellular Matrix; Glucose; Glutamic Acid; Glutamine; Homeostasis; Humans; Isocitrate Dehydrogenase; Isocitrates; Mitochondria; NADP; Neoplasms; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species; Spheroids, Cellular

2016
mTORC1-Dependent Metabolic Reprogramming Underlies Escape from Glycolysis Addiction in Cancer Cells.
    Cancer cell, 2016, Apr-11, Volume: 29, Issue:4

    Topics: Adenosine Triphosphate; Animals; Carcinoma; Cell Line, Tumor; Citric Acid Cycle; Combined Modality Therapy; Cytokines; Deoxyglucose; Drug Resistance, Neoplasm; Drug Synergism; Energy Metabolism; Everolimus; Female; Glucose-6-Phosphate Isomerase; Glutaminase; Glutamine; Glycolysis; Hep G2 Cells; Humans; Mechanistic Target of Rapamycin Complex 1; Metabolomics; Mice; Mice, Nude; Molecular Targeted Therapy; Multiprotein Complexes; Neoplasm Proteins; Neoplasms; Ovarian Neoplasms; Pentose Phosphate Pathway; Ribosomal Protein S6 Kinases, 70-kDa; RNA Interference; RNA, Small Interfering; TOR Serine-Threonine Kinases; Tumor Stem Cell Assay; Xenograft Model Antitumor Assays

2016
Glycoholics Anonymous: Cancer Sobers Up with mTORC1.
    Cancer cell, 2016, Apr-11, Volume: 29, Issue:4

    Topics: Glucose; Glutamine; Glycolysis; Humans; Neoplasms; Pentose Phosphate Pathway

2016
The oncogenic transcription factor c-Jun regulates glutaminase expression and sensitizes cells to glutaminase-targeted therapy.
    Nature communications, 2016, Apr-18, Volume: 7

    Topics: Animals; Base Sequence; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; Embryo, Mammalian; Fibroblasts; Gene Expression Regulation, Neoplastic; Glutaminase; Glutamine; Humans; MCF-7 Cells; Mice; Molecular Sequence Data; Neoplasms; Promoter Regions, Genetic; Protein Binding; Proto-Oncogene Mas; Proto-Oncogene Proteins c-jun; Reverse Transcriptase Polymerase Chain Reaction; rho GTP-Binding Proteins; RNA Interference

2016
Acidosis Drives the Reprogramming of Fatty Acid Metabolism in Cancer Cells through Changes in Mitochondrial and Histone Acetylation.
    Cell metabolism, 2016, 08-09, Volume: 24, Issue:2

    Topics: Acetyl Coenzyme A; Acetylation; Acidosis; Animals; Cell Line, Tumor; Cell Proliferation; Cell Respiration; Cellular Reprogramming; Electron Transport Complex I; Fatty Acids; Female; Glutamine; Histones; Humans; Hydrogen-Ion Concentration; Metabolic Networks and Pathways; Mice, Nude; Mitochondria; Models, Biological; Neoplasms; Oxidation-Reduction; Reactive Oxygen Species

2016
Supplementation with L-glutamine prevents tumor growth and cancer-induced cachexia as well as restores cell proliferation of intestinal mucosa of Walker-256 tumor-bearing rats.
    Amino acids, 2016, Volume: 48, Issue:12

    Topics: Animals; Cachexia; Carcinogenesis; Cell Proliferation; Dietary Supplements; Glutamine; Humans; Intestinal Mucosa; Neoplasms; Rats

2016
Mechanistic Basis of Glutaminase Activation: A KEY ENZYME THAT PROMOTES GLUTAMINE METABOLISM IN CANCER CELLS.
    The Journal of biological chemistry, 2016, Sep-30, Volume: 291, Issue:40

    Topics: Animals; Cell Line, Tumor; Enzyme Activation; Glutaminase; Glutamine; Humans; Mice; Neoplasm Proteins; Neoplasms; NIH 3T3 Cells; Protein Multimerization; Protein Structure, Secondary

2016
Glucose-dependent anaplerosis in cancer cells is required for cellular redox balance in the absence of glutamine.
    Scientific reports, 2016, 09-08, Volume: 6

    Topics: Antioxidants; Apoptosis; Cell Line, Tumor; Cell Survival; Citric Acid Cycle; Glucose; Glutamine; Glutathione; Humans; Neoplasms; Oxidation-Reduction; Pyruvic Acid; Reactive Oxygen Species

2016
Regional glutamine deficiency in tumours promotes dedifferentiation through inhibition of histone demethylation.
    Nature cell biology, 2016, Volume: 18, Issue:10

    Topics: Animals; DNA Methylation; Glutamine; Histone Demethylases; Histones; Humans; Ketoglutaric Acids; Methylation; Methyltransferases; Neoplasms

2016
Experimental Cancer Cachexia Changes Neuron Numbers and Peptide Levels in the Intestine: Partial Protective Effects after Dietary Supplementation with L-Glutamine.
    PloS one, 2016, Volume: 11, Issue:9

    Topics: Cachexia; Cell Line, Tumor; Dietary Supplements; Glutamine; Humans; Intestinal Mucosa; Neoplasms; Neurons

2016
Tumor-associated mutant p53 promotes cancer cell survival upon glutamine deprivation through p21 induction.
    Oncogene, 2017, 04-06, Volume: 36, Issue:14

    Topics: Animals; Cell Survival; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; Gene Expression Regulation, Neoplastic; Glutamine; HCT116 Cells; Humans; Mice; Mice, Nude; Mutant Proteins; Mutation; Neoplasms; Stress, Physiological; Tumor Suppressor Protein p53; Up-Regulation

2017
Addiction to Coupling of the Warburg Effect with Glutamine Catabolism in Cancer Cells.
    Cell reports, 2016, 10-11, Volume: 17, Issue:3

    Topics: Carcinogenesis; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Citric Acid Cycle; Genes, ras; Glutamine; Glycolysis; Humans; Isoenzymes; L-Lactate Dehydrogenase; Mutation; Neoplasms; Phenotype; Transaminases; Tumor Suppressor Protein p53

2016
The Quid Pro Quo of the Tumor/Stromal Interaction.
    Cell metabolism, 2016, 11-08, Volume: 24, Issue:5

    Topics: Caveolin 1; Fibroblasts; Glutamine; Humans; Neoplasms; Stromal Cells

2016
Systems biology analysis of drivers underlying hallmarks of cancer cell metabolism.
    Scientific reports, 2017, 01-25, Volume: 7

    Topics: Adenosine Triphosphate; Biomass; Cell Line, Tumor; Glucose; Glutamine; Glycolysis; Humans; Metabolic Flux Analysis; Metabolic Networks and Pathways; Metabolome; Neoplasms; Phenotype; Protein Biosynthesis; Systems Biology

2017
Regulation of stem-like cancer cells by glutamine through β-catenin pathway mediated by redox signaling.
    Molecular cancer, 2017, 02-28, Volume: 16, Issue:1

    Topics: A549 Cells; Animals; Asparaginase; ATP Binding Cassette Transporter, Subfamily G, Member 2; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Glutamine; Glutathione; Humans; Mice; Neoplasm Proteins; Neoplasms; Neoplastic Stem Cells; Oxidation-Reduction; Side-Population Cells; Wnt Signaling Pathway

2017
PTEN Regulates Glutamine Flux to Pyrimidine Synthesis and Sensitivity to Dihydroorotate Dehydrogenase Inhibition.
    Cancer discovery, 2017, Volume: 7, Issue:4

    Topics: Animals; Ataxia Telangiectasia Mutated Proteins; Dihydroorotate Dehydrogenase; DNA Damage; DNA Replication; Enzyme Inhibitors; Fibroblasts; Gene Knockout Techniques; Glutamine; Humans; Metabolic Networks and Pathways; Mice; Neoplasms; Oxidoreductases Acting on CH-CH Group Donors; PTEN Phosphohydrolase; Pyrimidines

2017
Cytosolic malate dehydrogenase activity helps support glycolysis in actively proliferating cells and cancer.
    Oncogene, 2017, 07-06, Volume: 36, Issue:27

    Topics: Apoptosis; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Gene Amplification; Glucose; Glutamine; Glycolysis; Humans; Isoenzymes; L-Lactate Dehydrogenase; Lactate Dehydrogenase 5; Lung Neoplasms; Malate Dehydrogenase; Neoplasms

2017
Finding an "Achilles' heel" of cancer: the role of glucose and glutamine metabolism in the survival of transformed cells.
    Cell cycle (Georgetown, Tex.), 2008, Jul-15, Volume: 7, Issue:14

    Topics: Animals; Cell Survival; Cell Transformation, Neoplastic; Glucose; Glutamine; Humans; Mice; Neoplasms

2008
Effect of added phosphate on glutamine desamidation in tumors.
    Journal of the National Cancer Institute, 1948, Volume: 8, Issue:4

    Topics: Glutamine; Humans; Neoplasms; Phosphates

1948
Tuning glutamine binding modes in Gd-DOTA-based probes for an improved MRI visualization of tumor cells.
    Chemistry (Weinheim an der Bergstrasse, Germany), 2009, Volume: 15, Issue:1

    Topics: Animals; Contrast Media; Cyclization; Glutamine; Hepatocytes; Heterocyclic Compounds; Magnetic Resonance Imaging; Neoplasms; Organometallic Compounds; Rats; Tumor Cells, Cultured

2009
When good nutrients go bad: can we predict nutrient-drug interactions?
    The British journal of nutrition, 2009, Volume: 102, Issue:3

    Topics: Cardiovascular Diseases; Complementary Therapies; Dietary Supplements; Fatty Acids, Omega-3; Food-Drug Interactions; Glutamine; Humans; Models, Immunological; Neoplasms

2009
Enteral administration of alanyl-[2-(15)N]glutamine contributes more to the de novo synthesis of arginine than does intravenous infusion of the dipeptide in humans.
    The American journal of clinical nutrition, 2009, Volume: 90, Issue:1

    Topics: Arginine; Body Mass Index; Citrulline; Dipeptides; Enteral Nutrition; Female; Gastrointestinal Diseases; Glutamine; Humans; Infusions, Intravenous; Isotope Labeling; Male; Middle Aged; Neoplasms; Nitrogen Isotopes

2009
Missense polymorphisms of PTPRJ and PTPN13 genes affect susceptibility to a variety of human cancers.
    Journal of cancer research and clinical oncology, 2010, Volume: 136, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Arginine; Biomarkers, Tumor; Case-Control Studies; Colorectal Neoplasms; Esophageal Neoplasms; Female; Genetic Predisposition to Disease; Genotype; Glutamine; Head and Neck Neoplasms; Humans; Incidence; Isoleucine; Japan; Lung Neoplasms; Male; Methionine; Middle Aged; Neoplasms; Polymorphism, Single Nucleotide; Proline; Protein Tyrosine Phosphatase, Non-Receptor Type 13; Receptor-Like Protein Tyrosine Phosphatases, Class 3; Risk Factors

2010
MYC, microRNAs and glutamine addiction in cancers.
    Cell cycle (Georgetown, Tex.), 2009, Oct-15, Volume: 8, Issue:20

    Topics: E2F1 Transcription Factor; Glutaminase; Glutamine; Humans; MicroRNAs; Neoplasms; Proto-Oncogene Proteins c-myc; S Phase

2009
PKM2 tyrosine phosphorylation and glutamine metabolism signal a different view of the Warburg effect.
    Science signaling, 2009, Nov-17, Volume: 2, Issue:97

    Topics: Animals; Cell Proliferation; Citric Acid Cycle; Glutamine; Glycolysis; Humans; Models, Biological; Neoplasms; Phosphorylation; Protein Multimerization; Pyruvate Kinase; Receptor, Fibroblast Growth Factor, Type 1; Signal Transduction; Tyrosine

2009
High glucose concentrations attenuate hypoxia-inducible factor-1alpha expression and signaling in non-tumor cells.
    Experimental cell research, 2010, Apr-15, Volume: 316, Issue:7

    Topics: Animals; Cells, Cultured; Dose-Response Relationship, Drug; Down-Regulation; Glucose; Glutamine; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Ketoglutaric Acids; Macrophages; Mice; Muscle Development; Myoblasts; Neoplasms; Osmolar Concentration; Signal Transduction

2010
Desamidation of glutamine and asparagine in normal and neoplastic hepatic tissues.
    Journal of the National Cancer Institute, 1947, Volume: 7, Issue:4

    Topics: Amino Acids; Asparagine; Glutamine; Liver Neoplasms; Neoplasms

1947
Q&A: Cancer: clues from cell metabolism.
    Nature, 2010, Jun-03, Volume: 465, Issue:7298

    Topics: Adenosine Triphosphate; Animals; Cell Hypoxia; Gene Expression Regulation, Neoplastic; Glucose; Glutamine; Glycolysis; Lactic Acid; Metabolic Networks and Pathways; Neoplasms; Oxidative Phosphorylation; Oxygen

2010
Oncology's energetic pipeline.
    Nature biotechnology, 2010, Volume: 28, Issue:9

    Topics: Animals; Antineoplastic Agents; Dichloroacetic Acid; Drug Industry; Energy Metabolism; Glutamine; Glycolysis; Humans; Neoplasms

2010
Nitrogen anabolism underlies the importance of glutaminolysis in proliferating cells.
    Cell cycle (Georgetown, Tex.), 2010, Oct-01, Volume: 9, Issue:19

    Topics: Alanine; Ammonia; Aspartic Acid; Carbon; Cell Line, Tumor; Cell Proliferation; Energy Metabolism; Glucose; Glutamine; Humans; Ketoglutaric Acids; Metabolism; Mitochondria; Neoplasms; Nitrogen; Nucleic Acids; Stress, Physiological

2010
Glutaminolysis: supplying carbon or nitrogen or both for cancer cells?
    Cell cycle (Georgetown, Tex.), 2010, Oct-01, Volume: 9, Issue:19

    Topics: Amino Acids; Carbon; Citric Acid Cycle; Energy Metabolism; Glucose; Glutamic Acid; Glutamine; Glycolysis; Humans; Neoplasms; Nitrogen; Proto-Oncogene Proteins c-myc

2010
High-glycolytic cancers and their interplay with the body's glucose demand and supply cycle.
    Medical hypotheses, 2011, Volume: 76, Issue:2

    Topics: Animals; Blood Glucose; Brain; Cell Line, Tumor; Fatty Acids; Gene Expression Regulation, Neoplastic; Glutamine; Glycolysis; Humans; Hypoxia; Immune System; Lactates; Models, Biological; Neoplasms; Treatment Outcome

2011
Synthesis of optically pure 4-fluoro-glutamines as potential metabolic imaging agents for tumors.
    Journal of the American Chemical Society, 2011, Feb-02, Volume: 133, Issue:4

    Topics: Biological Transport; Cell Line, Tumor; Glutamine; Halogenation; Humans; Isotope Labeling; Molecular Imaging; Neoplasms; Optical Phenomena; Stereoisomerism; Substrate Specificity

2011
Genome-scale metabolic modeling elucidates the role of proliferative adaptation in causing the Warburg effect.
    PLoS computational biology, 2011, Volume: 7, Issue:3

    Topics: Biomass; Cell Proliferation; Energy Metabolism; Gene Expression; Genome, Human; Glutamine; Glycolysis; Humans; Metabolic Networks and Pathways; Neoplasms

2011
Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth.
    Molecular systems biology, 2011, Aug-16, Volume: 7

    Topics: Animals; Cell Line, Transformed; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Citric Acid Cycle; Fibroblasts; Flow Cytometry; Gas Chromatography-Mass Spectrometry; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glucose; Glutamine; Glycolysis; Humans; Isotope Labeling; Mice; Neoplasms; NIH 3T3 Cells; Oligonucleotide Array Sequence Analysis; Proto-Oncogene Proteins p21(ras)

2011
Reductive carboxylation supports growth in tumour cells with defective mitochondria.
    Nature, 2011, Nov-20, Volume: 481, Issue:7381

    Topics: Acetyl Coenzyme A; Animals; Carcinoma, Renal Cell; Cell Hypoxia; Cell Line, Tumor; Citric Acid; Electron Transport; Electron Transport Complex I; Electron Transport Complex III; Fumarate Hydratase; Glucose; Glutamine; Humans; Isocitrate Dehydrogenase; Kidney Neoplasms; Mice; Mitochondria; NADP; Neoplasms

2011
Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Dec-06, Volume: 108, Issue:49

    Topics: Carboxylic Acids; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Cell Survival; Citrates; Citric Acid Cycle; Gas Chromatography-Mass Spectrometry; Glucose; Glutamine; Humans; Hypoxia-Inducible Factor 1; Immunoblotting; Isocitrate Dehydrogenase; Ketoglutaric Acids; Neoplasms; Oxidation-Reduction; RNA Interference

2011
Breathless cancer cells get fat on glutamine.
    Cell research, 2012, Volume: 22, Issue:3

    Topics: Glucose; Glutamine; Lipids; Neoplasms

2012
Glutamine and the tumor microenvironment: understanding the mechanisms that fuel cancer progression.
    Cancer biology & therapy, 2011, Dec-15, Volume: 12, Issue:12

    Topics: Autophagy; Glutamine; Humans; Mitochondria; Neoplasms

2011
Glutamine fuels a vicious cycle of autophagy in the tumor stroma and oxidative mitochondrial metabolism in epithelial cancer cells: implications for preventing chemotherapy resistance.
    Cancer biology & therapy, 2011, Dec-15, Volume: 12, Issue:12

    Topics: Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Caveolin 1; Cell Communication; Cell Line, Tumor; Chloroquine; Coculture Techniques; Epithelial Cells; Fibroblasts; Glutamine; Humans; Intracellular Signaling Peptides and Proteins; MCF-7 Cells; Mitochondria; Neoplasms; Oxidative Phosphorylation; Phosphoric Monoester Hydrolases; Stromal Cells; Tamoxifen; Tumor Microenvironment

2011
[Guidelines for specialized nutritional and metabolic support in the critically-ill patient. Update. Consensus of the Spanish Society of Intensive Care Medicine and Coronary Units-Spanish Society of Parenteral and Enteral Nutrition (SEMICYUC-SENPE): oncoh
    Medicina intensiva, 2011, Volume: 35 Suppl 1

    Topics: Cachexia; Critical Care; Critical Illness; Dietary Fats; Eicosapentaenoic Acid; Energy Intake; Energy Metabolism; Enteral Nutrition; Glutamine; Humans; Inflammation; Neoplasms; Nutritional Requirements; Parenteral Nutrition; Postoperative Care; Societies, Medical; Societies, Scientific; Spain

2011
Complexity of metabolic cancer control: can we exploit the superior metabolic position of glucose?
    Cancer biology & therapy, 2012, Volume: 13, Issue:8

    Topics: Autophagy; Glutamine; Humans; Mitochondria; Neoplasms

2012
Emerging concepts: linking hypoxic signaling and cancer metabolism.
    Cell death & disease, 2012, May-03, Volume: 3

    Topics: Cell Hypoxia; Glucose; Glutamine; Humans; Neoplasms; Signal Transduction

2012
Understanding tumor cell metabolism: the secret to winning the war (burg) on cancer?
    Seminars in cell & developmental biology, 2012, Volume: 23, Issue:4

    Topics: Animals; Glucose; Glutamine; Glycolysis; Humans; Neoplasms; Signal Transduction

2012
Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming.
    Cancer cell, 2012, Jul-10, Volume: 22, Issue:1

    Topics: Animals; Cell Division; Glucose; Glutamine; Mice; Mice, Transgenic; Neoplasms; NF-E2-Related Factor 2; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction

2012
The real face of HIF1α in the tumor process.
    Cell cycle (Georgetown, Tex.), 2012, Nov-01, Volume: 11, Issue:21

    Topics: Ammonia; Glucose Transporter Type 1; Glutamic Acid; Glutamine; Humans; Hydrogen-Ion Concentration; Hypoxia-Inducible Factor 1, alpha Subunit; Neoplasms; Quaternary Ammonium Compounds

2012
An in vivo large-scale chemical screening platform using Drosophila for anti-cancer drug discovery.
    Disease models & mechanisms, 2013, Volume: 6, Issue:2

    Topics: Animals; Antineoplastic Agents; Benzamides; Biological Availability; Cell Proliferation; Cytidine Triphosphate; Diphenylamine; Drosophila melanogaster; Drug Screening Assays, Antitumor; Glutamine; Isoxazoles; Neoplasms; Pharmacogenetics; Pilot Projects

2013
Inactivation of the glutamine/amino acid transporter ASCT2 by 1,2,3-dithiazoles: proteoliposomes as a tool to gain insights in the molecular mechanism of action and of antitumor activity.
    Toxicology and applied pharmacology, 2012, Nov-15, Volume: 265, Issue:1

    Topics: Amino Acid Transport System ASC; Amino Acid Transport Systems; Animals; Antineoplastic Agents; Binding Sites; Computer Simulation; Cysteine; Dose-Response Relationship, Drug; Glutamine; Kinetics; Minor Histocompatibility Antigens; Neoplasms; Proteolipids; Rats; Structure-Activity Relationship; Thiazoles

2012
Multiple metabolic alterations exist in mutant PI3K cancers, but only glucose is essential as a nutrient source.
    PloS one, 2012, Volume: 7, Issue:9

    Topics: Cell Line, Tumor; Cell Proliferation; Class I Phosphatidylinositol 3-Kinases; Enzyme Activation; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Targeting; Glucose; Glutamine; Glycolysis; Humans; Metabolome; Mutant Proteins; Mutation; Neoplasms; Phosphatidylinositol 3-Kinases; Up-Regulation

2012
c-Myc and cancer metabolism.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2012, Oct-15, Volume: 18, Issue:20

    Topics: Cell Proliferation; Cell Transformation, Neoplastic; Gene Expression Regulation, Neoplastic; Glutamine; Glycolysis; Humans; Mitochondria; Molecular Targeted Therapy; Neoplasms; Proto-Oncogene Proteins c-myc

2012
Molecular pathways: regulation of metabolism by RB.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2012, Nov-15, Volume: 18, Issue:22

    Topics: Animals; Carbohydrate Metabolism; Glucose; Glutamine; Humans; Mitochondria; Molecular Targeted Therapy; Neoplasms; Retinoblastoma Protein

2012
A proposed role for glutamine in cancer cell growth through acid resistance.
    Cell research, 2013, Volume: 23, Issue:5

    Topics: Alkanesulfonic Acids; Ammonia; Cell Proliferation; Glutaminase; Glutamine; HeLa Cells; Humans; Hydrogen-Ion Concentration; Kidney; Liver; MCF-7 Cells; Neoplasms; Piperazines

2013
The growth response of mammalian cells in tissue culture to L-glutamine and L-glutamic acid.
    The Journal of biological chemistry, 1956, Volume: 218, Issue:2

    Topics: Animals; Glutamates; Glutamic Acid; Glutamine; Humans; Neoplasms; Tissue Culture Techniques

1956
Dual requirement of Walker carcinosarcoma 256 in vitro for asparagine and glutamine.
    Science (New York, N.Y.), 1956, Jul-20, Volume: 124, Issue:3212

    Topics: Animals; Asparagine; Biochemical Phenomena; Carcinoma 256, Walker; Glutamine; Humans; In Vitro Techniques; Neoplasms

1956
8-Hydroxylysine: an inhibitor of glutamine and protein synthesis by the Ehrlich ascites carcinoma cell.
    Cancer research, 1957, Volume: 17, Issue:9

    Topics: Ascites; Glutamine; Hydroxylysine; Lysine; Neoplasms; Protein Biosynthesis; Proteins

1957
The inhibition by glutamine of glutamyl transferase formation in cultures of human cells.
    Biochimica et biophysica acta, 1958, Volume: 27, Issue:2

    Topics: Aminoacyltransferases; Glutamine; Humans; Neoplasms; Transferases

1958
Specific rotation of phenylacetylglutamine excreted by cancer patients and normal subjects.
    Experientia, 1958, Jul-15, Volume: 14, Issue:7

    Topics: Encephalomyelitis; Glutamine; Neoplasms; Rotation

1958
Biochemical changes during experimental carcinogenesis. II. Glutamine and glutamic acid metabolism in perfused livers of azo dye-fed rats.
    Cancer research, 1959, Volume: 19, Issue:2

    Topics: Animals; Azo Compounds; Carcinogenesis; Carcinogens; Glutamates; Glutamine; Liver Neoplasms; Neoplasms; Rats

1959
Effect of glutamine analogs on amino acid incorporation into protein of some normal and neoplastic cells in vitro.
    Cancer research, 1959, Volume: 19, Issue:4

    Topics: Amino Acids; Glutamine; In Vitro Techniques; Neoplasms; Proteins

1959
Glutamine metabolism of normal and malignant cells cultivated in synthetic media.
    Nature, 1959, Apr-25, Volume: 183, Issue:4669

    Topics: Cell Count; Glutamine; Humans; Neoplasms; Neoplasms, Experimental; Research Design; Tissue Culture Techniques

1959
The effect of glucose on glutamine utilization by Ehrlich ascites tumor cells.
    Cancer research, 1961, Volume: 21

    Topics: Animals; Carcinoma, Ehrlich Tumor; Glucose; Glutamine; Humans; Neoplasms

1961
Effect of anaerobiosis and addition of keto acids on glutamine utilization by Ehrlich ascites-tumor cells.
    Biochimica et biophysica acta, 1960, Jul-29, Volume: 42

    Topics: Anaerobiosis; Ascites; Biochemical Phenomena; Glutamine; Kernicterus; Keto Acids; Neoplasms

1960
A study of free amino acids and of glutamine synthesis in tumor-bearing rats.
    Cancer research, 1960, Volume: 20

    Topics: Amino Acids; Animals; Glutamine; Neoplasms; Rats

1960
[POTENTIAL ANTICANCER AGENTS. I. SYNTHESIS OF DERIVATIVES OF GLUTAMINE AND RELATED COMPOUNDS].
    Yao xue xue bao = Acta pharmaceutica Sinica, 1963, Volume: 10

    Topics: Antineoplastic Agents; Chemical Phenomena; Chemistry; Glutamine; Neoplasms; Neoplasms, Experimental; Research

1963
ASPARAGINE-C14 AND GLUTAMINE-C14 FROM ANIMAL CELL PROTEIN AND THEIR CHEMICAL DEGRADATION.
    Analytical biochemistry, 1963, Volume: 6

    Topics: Animals; Asparagine; Aspartic Acid; Carbon Isotopes; Chromatography; Glutamine; Ion Exchange Resins; Malates; Neoplasm Proteins; Neoplasms; Neoplasms, Experimental; Proteins; Research; Sarcoma; Sarcoma, Experimental

1963
A TRANSPORT SYSTEM SERVING FOR MONO- AND DIAMINO ACIDS.
    Proceedings of the National Academy of Sciences of the United States of America, 1964, Volume: 51

    Topics: Amino Acids; Aminobutyrates; Aminoisobutyric Acids; Arginine; Asparagine; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Glutamine; Glycine; Leucine; Lysine; Neoplasms; Ornithine; Phenylalanine; Proteins; Research

1964
FREE AMINO ACIDS OF HUMAN BREAST CANCER.
    The Nebraska state medical journal, 1964, Volume: 49

    Topics: Amino Acids; Asparagine; Aspartic Acid; Breast Neoplasms; Chromatography; Citrulline; Glutamates; Glutamine; Glycine; Humans; Isoleucine; Leucine; Liver Neoplasms; Lung Neoplasms; Mice; Neoplasms; Neoplasms, Experimental; Phenylalanine; Proline; Research; Serine; Threonine; Tyrosine

1964
[INCORPORATION OF FORMATE-C14 IN THE BASES OF THE NUCLEIC ACIDS OF STICKER'S TUMOR IN VIVO AND IN VITRO].
    Bollettino della Societa italiana di biologia sperimentale, 1963, Dec-31, Volume: 39

    Topics: Adenine; Aspartic Acid; Carbon Isotopes; DNA; DNA, Neoplasm; Dogs; Formates; Glucose; Glutamine; In Vitro Techniques; Metabolism; Neoplasms; Neoplasms, Experimental; Nucleic Acids; Pharmacology; Research; RNA; RNA, Neoplasm; Thymine

1963
[CONDITION OF THE AMMONIA-GLUTAMINE-GLUTAMIC ACID SYSTEM IN THE RAT BRAIN DURING THE DEVELOPMENT OF M-1 SARCOMA].
    Doklady Akademii nauk SSSR, 1964, Apr-21, Volume: 155

    Topics: Ammonia; Animals; Brain; Brain Chemistry; Glutamates; Glutamic Acid; Glutamine; Metabolism; Neoplasms; Rats; Research; Sarcoma; Sarcoma, Experimental

1964
S-Carbamylcysteine inhibition of protein synthesis by Ehrlich ascites tumor cells.
    Journal of the National Cancer Institute, 1962, Volume: 28

    Topics: Animals; Carcinoma, Ehrlich Tumor; Cysteine; Glutamine; Humans; Neoplasms; Protein Biosynthesis; Proteins

1962
An uncleavable form of pro-scatter factor suppresses tumor growth and dissemination in mice.
    The Journal of clinical investigation, 2004, Volume: 114, Issue:10

    Topics: Amino Acid Substitution; Animals; Breast Neoplasms; Carcinoma; Cell Line, Tumor; Collagen; Enzyme Activation; Extracellular Matrix; Female; Genetic Therapy; Genetic Vectors; Glutamine; Hepatocyte Growth Factor; Humans; Lentivirus; Methionine; Mice; Mice, Nude; Mitosis; Neoplasm Metastasis; Neoplasm Transplantation; Neoplasms; Protein Engineering; Protein-Tyrosine Kinases; Recombinant Proteins; Transduction, Genetic; Transplantation, Heterologous; Tumor Burden

2004
Modulation of tumor induced angiogenesis in Ehrlich ascites tumor.
    Journal of experimental & clinical cancer research : CR, 2004, Volume: 23, Issue:4

    Topics: Animals; Antineoplastic Agents; Body Weight; Carcinoma, Ehrlich Tumor; Cell Line, Tumor; Cell Proliferation; Diazooxonorleucine; Dose-Response Relationship, Drug; Down-Regulation; Female; Gene Expression Regulation, Neoplastic; Glutaminase; Glutamine; Mice; Neoplasm Transplantation; Neoplasms; Neovascularization, Pathologic; Ovarian Neoplasms; Time Factors; Vascular Endothelial Growth Factor A

2004
New strategies for management of oral mucositis in cancer patients.
    The journal of supportive oncology, 2006, Volume: 4, Issue:2 Suppl 1

    Topics: Antineoplastic Agents; Combined Modality Therapy; Drug Delivery Systems; Fibroblast Growth Factor 7; Glutamine; Growth Substances; Humans; Mouth Mucosa; Mucositis; Neoplasms; Practice Guidelines as Topic; Radiotherapy; Risk Factors

2006
Acivicin: a new glutamine antagonist in clinical trials.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1984, Volume: 2, Issue:9

    Topics: Animals; Antibiotics, Antineoplastic; Antimetabolites; Dose-Response Relationship, Drug; Drug Evaluation; Female; Glutamine; Half-Life; Humans; Isoxazoles; Kinetics; Leukemia, Experimental; Liver Neoplasms, Experimental; Macaca mulatta; Male; Mice; Neoplasms; Oxazoles; Purines; Pyrimidines; Sarcoma, Experimental

1984
[Effect of Litoralon therapy on the lymphocytotoxicity in patients with malignant tumors].
    Orvosi hetilap, 1984, Sep-02, Volume: 125, Issue:36

    Topics: Antibody-Dependent Cell Cytotoxicity; Cytotoxicity Tests, Immunologic; Cytotoxicity, Immunologic; Glutamine; Humans; In Vitro Techniques; Neoplasms; Taurine

1984
Phase I evaluation of AT-125 single dose every three weeks.
    Investigational new drugs, 1984, Volume: 2, Issue:3

    Topics: Adult; Aged; Antibiotics, Antineoplastic; Central Nervous System; Drug Administration Schedule; Drug Evaluation; Glutamine; Humans; Isoxazoles; Middle Aged; Neoplasms; Oxazoles

1984
The human hair follicle engages in glutaminolysis and aerobic glycolysis: implications for skin, splanchnic and neoplastic metabolism.
    Skin pharmacology : the official journal of the Skin Pharmacology Society, 1994, Volume: 7, Issue:1-2

    Topics: Adenosine Triphosphate; Aerobiosis; Cells, Cultured; Energy Metabolism; Fatty Acids; Glutamine; Glycolysis; Hair; Humans; Neoplasms; Skin; Viscera

1994
Glutamine and glutamate in ascitic fluid of dogs.
    European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies, 1993, Volume: 31, Issue:2

    Topics: Amino Acids; Animals; Ascites; Ascitic Fluid; Dog Diseases; Dogs; Glutamates; Glutamic Acid; Glutamine; Heart Failure; Hypoproteinemia; Liver Cirrhosis; Neoplasms; Peritonitis

1993
Glutamine stability in biological tissues evaluated by fluorometric analysis.
    Clinical chemistry, 1993, Volume: 39, Issue:6

    Topics: Drug Stability; Glutamine; Humans; Hydrogen-Ion Concentration; Liver; Male; Neoplasms; Solutions; Temperature; Time Factors

1993
Claude H. Organ, Jr. Honorary Lectureship. Glutamine, cancer, and its therapy.
    American journal of surgery, 1996, Volume: 172, Issue:5

    Topics: Clinical Trials as Topic; Combined Modality Therapy; Glutamine; Glutathione; Humans; Immune System; Killer Cells, Natural; Neoplasms; Radiation Injuries

1996
Cystine levels, cystine flux, and protein catabolism in cancer cachexia, HIV/SIV infection, and senescence.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 1997, Volume: 11, Issue:1

    Topics: Adipose Tissue; Adolescent; Adult; Aging; Animals; Cachexia; CD4 Lymphocyte Count; Citrulline; Cystine; Female; Glutamine; HIV Infections; Humans; Macaca; Male; Middle Aged; Muscle Proteins; Muscle, Skeletal; Neoplasms; Simian Acquired Immunodeficiency Syndrome; Taurine

1997
Should cancer patients with incurable disease receive parenteral or enteral nutritional support?
    European journal of cancer (Oxford, England : 1990), 1998, Volume: 34, Issue:3

    Topics: Arginine; Decision Making; Enteral Nutrition; Fatty Acids, Omega-3; Glutamine; Humans; Neoplasms; Parenteral Nutrition; Prognosis; Quality of Life; Terminal Care

1998
Glutamine treatment of paclitaxel-induced myalgias and arthralgias.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1998, Volume: 16, Issue:12

    Topics: Adult; Anti-Inflammatory Agents; Antineoplastic Agents, Phytogenic; Arthralgia; Female; Glutamine; Humans; Male; Middle Aged; Muscles; Neoplasms; Paclitaxel; Pain

1998
Cooperative research group members question advertisement.
    Oncology nursing forum, 2001, Volume: 28, Issue:3

    Topics: Advertising; Clinical Nursing Research; Clinical Trials as Topic; Glutamine; Humans; Interprofessional Relations; Neoplasms; Oncology Nursing; Periodicals as Topic; Truth Disclosure

2001
Influence of glutamine and glycyl-glutamine on in vitro lymphocyte proliferation in children with solid tumors.
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2001, Volume: 9, Issue:4

    Topics: Adolescent; Cells, Cultured; Child; Child, Preschool; Dipeptides; Female; Glutamine; Humans; Immunity, Cellular; Infant; Lymphocyte Activation; Lymphocytes; Male; Neoplasms

2001
L-glutamine.
    Alternative medicine review : a journal of clinical therapeutic, 2001, Volume: 6, Issue:4

    Topics: Acquired Immunodeficiency Syndrome; Dietary Supplements; Gastrointestinal Diseases; Glutamine; Humans; Neoplasms; Wound Healing

2001
Metabolic cooperation between different oncogenes during cell transformation: interaction between activated ras and HPV-16 E7.
    Oncogene, 2001, Oct-18, Volume: 20, Issue:47

    Topics: Adenylate Kinase; Animals; Aspartate Aminotransferases; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Glutamine; Glycolysis; Kidney; Models, Biological; Neoplasms; Nucleotides; Oncogene Protein p21(ras); Oncogene Proteins, Viral; Papillomavirus E7 Proteins; Pyruvate Kinase; Rats; Serine; Transfection

2001
[The effect of L-Glutamine and Shakuyaku-Kanzo-to for paclitaxel-induced myalgia/arthralgia].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2002, Volume: 29, Issue:4

    Topics: Antineoplastic Agents, Phytogenic; Arthralgia; Drug Administration Schedule; Drug Combinations; Drugs, Chinese Herbal; Female; Glutamine; Glycyrrhiza; Humans; Muscle, Skeletal; Neoplasms; Paclitaxel; Paeonia; Pain; Quality of Life

2002
Imaging of spontaneous canine tumours with ammonia and L-glutamine labeled with N-13.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1977, Volume: 18, Issue:7

    Topics: Ammonia; Animals; Dog Diseases; Dogs; Female; Glutamine; Lymphoma, Non-Hodgkin; Male; Mesothelioma; Neoplasms; Nitrogen Radioisotopes; Radionuclide Imaging; Thoracic Neoplasms

1977
Availability of glutamine from peptides and acetylglutamine for human tumor-cell cultures.
    Metabolism: clinical and experimental, 1989, Volume: 38, Issue:8 Suppl 1

    Topics: Breast Neoplasms; Cell Division; Dipeptides; DNA; Glutamine; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Neoplasms; Pancreatic Neoplasms; Stomach Neoplasms; Tumor Cells, Cultured

1989
Immunosuppressive enzymes.
    Transplantation proceedings, 1973, Volume: 5, Issue:3

    Topics: Animals; Antigens; Asparaginase; Asparagine; Encephalomyelitis, Autoimmune, Experimental; Erythrocytes; Glutamine; Graft vs Host Reaction; Hemocyanins; Hemolytic Plaque Technique; Humans; Hypersensitivity, Delayed; Immunosuppressive Agents; Lymphocyte Activation; Lymphocytes; Mice; Mitogens; Neoplasms; Sheep; Skin Tests; Skin Transplantation; Transplantation Immunology; Transplantation, Homologous

1973
Survey of two types of glutaminases in plasma of patients suffering from cancer & other diseases.
    Indian journal of experimental biology, 1974, Volume: 12, Issue:2

    Topics: Adult; Chronic Disease; Female; Glutaminase; Glutamine; Humans; Male; Middle Aged; Neoplasms; Pregnancy; Transaminases

1974
Sensitivity to L-asparaginase and amino acid metabolism.
    Journal of the National Cancer Institute, 1970, Volume: 44, Issue:5

    Topics: Amino Acids; Animals; Asparaginase; Asparagine; Carbon Isotopes; Carcinoma 256, Walker; Citrulline; Culture Techniques; Female; Formates; Glutamine; Half-Life; Humans; Leukemia; Leukemia, Experimental; Male; Mice; Neoplasms; Rats; Spleen; Thymidine; Time Factors; Tritium

1970
The erythrocyte plasma distribution of amino acids in health and disease.
    Clinica chimica acta; international journal of clinical chemistry, 1968, Volume: 20, Issue:1

    Topics: Acute Disease; Adolescent; Adult; Alanine; Amino Acids; Anemia, Hemolytic; Anemia, Pernicious; Bronchitis; Bronchopneumonia; Chromatography, Paper; Erythrocytes; Female; Glutamates; Glutamine; Glycine; Hepatitis; Humans; Hyperthyroidism; Infections; Inflammation; Isoleucine; Leucine; Male; Methionine; Neoplasms; Plasma; Pyelitis; Serine; Threonine; Valine

1968
[The glutamine levels in the serum of tumor patients].
    Klinische Wochenschrift, 1968, Jan-01, Volume: 46, Issue:1

    Topics: Ammonia; Chromatography, Paper; Glutamine; Humans; Neoplasms

1968
Amino acid levels following L-asparagine amidohydrolase (EC.3.5.1.1) therapy.
    Cancer research, 1969, Volume: 29, Issue:1

    Topics: Amidohydrolases; Amino Acids; Asparaginase; Asparagine; Female; Glutamates; Glutamine; Humans; Male; Neoplasms

1969