Compounds > glutamine

glutamine and Alzheimer Disease

glutamine has been researched along with Alzheimer Disease in 88 studies

Research

Studies (88)

TimeframeStudies, this research(%)All Research%
pre-19905 (5.68)18.7374
1990's15 (17.05)18.2507
2000's27 (30.68)29.6817
2010's21 (23.86)24.3611
2020's20 (22.73)2.80

Authors

AuthorsStudies
Aldana, BI; Andersen, JV; Christensen, SK; Diaz-delCastillo, M; Freude, KK; Gentry, MS; Haukedal, H; Kohlmeier, KA; Mann, M; Markussen, KH; Polli, FS; Schousboe, A; Shabani, M; Skotte, NH; Sun, RC; Tanila, H; Waagepetersen, HS; Westi, EW1
Chen, KL; Chen, SD; Dong, Q; Huang, SY; Kuo, K; Li, HQ; Shen, XN; Tan, L; Yang, YX; Yu, JT; Zhang, YR1
Dong, X; Sun, Y; Xu, S1
Andersen, JV; Schousboe, A; Verkhratsky, A1
Chen, GC; Guo, D; Jia, Y; Liu, F; Shi, M; Sun, L; Wang, Y; Yang, P; Zhang, Y; Zhu, Z1
Aliakbarzadeh, F; Hashemi, R; Khodagholi, F; Motamedi, F; Naderi, N; Naderi, S; Pourbadie, HG; Sayehmiri, F1
Cai, Z; Chen, Y; Shi, Y; Sun, Y; Wang, J; Wang, Q; Wang, W; Zhang, H; Zhang, X1
Cheng, S; Deng, S; Huang, B; Huang, X; Liu, P; Song, Z; Wu, Z; Yang, J1
Baek, JH; Kang, JS; Kim, HJ; Lee, DK; Song, M1
Cheng, JY; Deng, YT; Yu, JT1
Howell, JC; Hu, WT; Jones, DP; Miller, GW; Niedzwiecki, MM; Walker, DI; Watts, KD1
Adams, CD1
Hollinger, KR; Kamiya, A; Kannan, S; Khoury, ES; Liaw, K; Prchalova, E; Rojas, C; Slusher, BS; Tallon, C; Thomas, AG; Wu, Y; Zhu, X1
Findley, CA; Hascup, ER; Hascup, KN; Sime, LN1
Aldana, BI; Andersen, JV; Christensen, SK; Diaz-delCastillo, M; Schousboe, A; Tanila, H; Waagepetersen, HS; Westi, EW1
Calabresi, P; Casamassa, A; Di Maio, A; Donati, G; Errico, F; Gaetani, L; Isidori, A; Mancini, A; Miroballo, M; Nuzzo, T; Paoletti, FP; Parnetti, L; Sansone, G; Usiello, A1
Aldana, BI; Andersen, JV; Freude, KK; Salcedo, C; Schousboe, A; Vinten, KT; Waagepetersen, HS; Wagner, A1
Chiu, PW; Herrup, K; Ip, I; Liu, T; Mak, HKF; Song, YQ; Wong, GHY; Wong, SWH; Zhang, H1
Caligiuri, ME1
Aldana, BI; Andersen, JV; Freude, KK; Hannibal, J; Kolko, M; Mouhammad, ZA; Sanz-Morello, B; Tams, ALM; Vohra, R; Westi, EW1
Jose, J; Lakhotia, SC; Patel, AB; Saba, K; Tiwari, V; Veeraiah, P1
Bak, LK; Schousboe, A; Waagepetersen, HS; Walls, AB1
Pan, H; Shu, Q; Sun, B; Wang, D; Wang, M; Zhang, X; Zhou, D1
Fan, S; Hu, Y; Li, L; Li, W; Xian, X; Yao, X; Zhang, M1
Abe, K; Hishikawa, N; Huang, Y; Liu, X; Morihara, R; Ohta, Y; Sato, K; Shang, J; Shi, X; Takemoto, M; Yamashita, T2
Aytan, N; Carreras, I; Choi, JK; Dedeoglu, A; Jenkins, BG; Kowall, NW; McKee, AC1
Cadenas, E; Díaz Brinton, R; Kanamori, K; Patil, I; Ross, BD; Sancheti, H1
Nilsen, LH; Sonnewald, U; Witter, MP1
Chen, SD; Deng, YL; Huang, FJ; Jia, W; Liu, JJ; Ma, JF; Ren, RJ; Tang, HD; Wang, G; Wang, Y; Xu, W; Xu, XH; Zhang, YN; Zhao, AH; Zhou, Y1
Allan, K; Barnham, KJ; Burke, R; Camakaris, J; Perez, KA1
Doert, A; Eckert, GP; Müller, WE; Pilatus, U; Zanella, F1
Choe, BY; Jahng, GH; Kim, HG; Lee, DW; Lee, KM; Oh, J; Paik, JW; Park, S; Rhee, HY; Ryu, CW; Shin, W1
Chen, J; Chen, Y; Chow, H; Hart, RP; Herrup, K; Li, J; Louie, L; Plummer, MR; Vail, G; Zhang, Y1
Blamire, AM; Hayes, L; He, J; O'Brien, JT; Su, L; Watson, R1
Huang, D; Liu, D; Ni, H; Qian, T; Shrestha, S; Yin, J1
Büchmann-Møller, S; Dahmcke, CM; Jensen, NA; Mitchelmore, C1
Hovorková, P; Klaschka, J; Kozmiková, I; Kristofiková, Z; Majer, E; Rícný, J; Rípová, D; Zach, P1
Frölich, L; Kratzsch, T; Lais, C; Lanfermann, H; Maurer, K; Pantel, J; Pilatus, U; Rochmont, Adu M; Zanella, FE1
Demuth, HU; Koch, B; Manhart, S; Schilling, S; Schulz, K; Seifert, F1
Robinson, SR; Steele, ML1
Bird, TD; Ghetti, B; Jayadev, S; Leverenz, JB; Mastrianni, JA; Montine, TJ; Nochlin, D; Poorkaj, P; Schellenberg, GD; Steinbart, EJ1
Behar, KL; De Feyter, HM; de Graaf, RA; Mason, GF; Rothman, DL1
Barcikowska, M; Ćwikła, JB; Gabryelewicz, T; Walecki, J1
Chen, J; Herrup, K1
Aksenov, M; Aksenova, M; Booze, R; Butterfield, DA; Castegna, A; Klein, JB; Markesbery, WR; Pierce, WM; Thongboonkerd, V1
Boeve, BF; Edland, SD; Ivnik, RJ; Jack, CR; Kantarci, K; Knopman, DS; Petersen, RC; Reynolds, G; Smith, GE; Tangalos, EG1
Ariza, A; Beyer, K; Fernández-Figueras, MT; Lao, JI; Latorre, P; Mate, JL; Matute, B; Riutort, N1
Brooks, WS; Fisher, C; Fonte, J; Ghika, J; Gnjec, A; Martins, RN; Masters, CL; McLean, CA; Mehta, PD; Miklossy, J; Suard, F; Suva, D; Taddei, K; Verdile, G1
Devreese, B; Fésüs, L; Nemes, Z; Steinert, PM; Van Beeumen, J1
Bier, JC; Sternon, J1
Aasly, J; Gårseth, M; Sonnewald, U; White, LR1
Hashimoto, Y; Kitazume, S; Saido, TC; Suzuki, M1
Bresolin, N; Comi, GP; Del Bo, R; Dominici, R; Fenoglio, C; Forloni, G; Galbiati, S; Galimberti, D; Gatti, A; Guidi, I; Lovati, C; Mariani, C; Pomati, S; Scarpini, E; Venturelli, E; Virgilio, R1
Cammisa, G; D'Aniello, A; D'Aniello, E; Fisher, G; Migliaccio, N; Spinelli, P1
Conrads, TP; Johnson, MD; Kinoshita, Y; McBee, JK; Morrison, RS; Uo, T; Veenstra, TD; Yu, LR1
da Silva, AL; Dall'Igna, OP; Hoffmann, A; Lara, DR; Souza, DO1
Dodd, PR; Walton, HS1
Hayashi, H; Kagamihara, Y; Kawata, A; Matsubara, S; Sugaya, K1
Butterfield, DA; Sultana, R1
Lv, Z; Ma, X; Wang, B; Wang, J; Xie, YC; Yang, Z; Zhang, P; Zheng, C; Zhou, S1
Baumketner, A; Krone, MG; Shea, JE1
Amaducci, L; Latorraca, S; Piacentini, S; Piersanti, P; Sorbi, S1
Gliemann, J; Jensen, PH; Petersen, TE; Rasmussen, LK; Sørensen, ES1
Ikura, K; Sasaki, R; Takahata, K1
Bowen, DM; Francis, PT; Procter, AW; Sims, NR1
Attal, N; Laplane, D; Lejeune, J; Mircher, C; Peeters, MA; Rethore, MO; Salabelle, A1
Davis, J; Van Nostrand, WE1
Bardgett, ME; Csernansky, JG; Morris, JC; Olney, JW; Sheline, YI1
Kornhuber, J; Weller, M1
Chang, L; Ernst, T; Mehringer, CM; Melchor, R1
Bayer, S; Hennig, J; Langer, M; Laubenberger, J; Thiel, T1
Blain, H; Guéant, JL; Jeandel, C; Lefebvre, E; Redjems-Bennani, N; Vidailhet, M1
Kondoh, T; Matsuoka, T; Nishizaki, T; Nomura, T; Shiotani, T; Watabe, S; Yoshii, M1
Atwood, CS; Bush, AI; Huang, X; Khatri, A; Kim, YS; Moir, RD; Roher, AE; Scarpa, RC; Tanzi, RE1
Antuono, PG; Jones, JL; Li, SJ; Wang, Y1
Wilkinson, D1
Abe, K; Hattori, N; Sakoda, S; Sawada, T1
Berriman, J; Finch, JT; Lesk, A; Perutz, MF1
Klunk, WE; McClure, RJ; Moossy, J; Panchalingam, K; Pettegrew, JW1
Hardy, J1
Frangione, B; Ghiso, J; Wisniewski, T1
Davidson, M; Stern, RG1
Bowen, DM; Esiri, MM; Francis, PT; Hunt, A; Lowe, SL; Najlerahim, A; Palmer, AM; Patel, AJ; Procter, AW; Stratmann, GC1
Avila, J; Montejo de Garcini, E; Serrano, L1
Deutsch, SI; Morihisa, JM1
Bowen, DM; Doshi, R; Francis, PT; Lowe, SL; Murphy, E; Neary, D; Palmer, AM; Procter, AW1
Goldman, JE; Peterson, C1

Reviews

14 review(s) available for glutamine and Alzheimer Disease

ArticleYear
Astrocyte energy and neurotransmitter metabolism in Alzheimer's disease: Integration of the glutamate/GABA-glutamine cycle.
    Progress in neurobiology, 2022, Volume: 217

    Topics: Alzheimer Disease; Astrocytes; Energy Metabolism; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Neurotransmitter Agents

2022
Association between Human Blood Metabolome and the Risk of Alzheimer's Disease.
    Annals of neurology, 2022, Volume: 92, Issue:5

    Topics: Alzheimer Disease; Biomarkers; Genome-Wide Association Study; Glutamine; Humans; Mendelian Randomization Analysis; Metabolome; Sphingomyelins

2022
Astrocytic glycogen metabolism in the healthy and diseased brain.
    The Journal of biological chemistry, 2018, 05-11, Volume: 293, Issue:19

    Topics: Alzheimer Disease; Animals; Astrocytes; Brain; Calcium; Cyclic AMP; Diabetes Mellitus, Type 2; Glutamine; Glycogen; Glycogen Phosphorylase; Humans; Isoenzymes; Learning; Memory; Neurotransmitter Agents; Potassium; Signal Transduction; Sleep

2018
13C MRS studies of neuroenergetics and neurotransmitter cycling in humans.
    NMR in biomedicine, 2011, Volume: 24, Issue:8

    Topics: Aging; Alzheimer Disease; Animals; Brain; Carbon Isotopes; Citric Acid Cycle; Energy Metabolism; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Neurons; Neurotransmitter Agents

2011
[Memantine (Ebixa), glutaminergic modulator].
    Revue medicale de Bruxelles, 2004, Volume: 25, Issue:2

    Topics: Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Excitatory Amino Acid Antagonists; Glutamic Acid; Glutamine; Humans; Indans; Memantine; Piperidines

2004
Involvement of proteases in glycosyltransferase secretion: Alzheimer's beta-secretase-dependent cleavage and a following processing by an aminopeptidase.
    Glycoconjugate journal, 2004, Volume: 21, Issue:1-2

    Topics: Alanine; Alzheimer Disease; Amino Acid Sequence; Aminopeptidases; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; beta-D-Galactoside alpha 2-6-Sialyltransferase; Cell Membrane; COS Cells; Detergents; Endopeptidases; Glutamine; Golgi Apparatus; Humans; Leucine; Models, Biological; Molecular Sequence Data; Mutation; Peptide Hydrolases; Protein Structure, Tertiary; Sialyltransferases; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

2004
The proteomics of neurodegeneration.
    American journal of pharmacogenomics : genomics-related research in drug development and clinical practice, 2005, Volume: 5, Issue:4

    Topics: Alzheimer Disease; Animals; Down Syndrome; Glutamine; Humans; Motor Neuron Disease; Neurodegenerative Diseases; Parkinson Disease; Proteomics; tau Proteins; Trauma, Nervous System

2005
Glutamate-glutamine cycling in Alzheimer's disease.
    Neurochemistry international, 2007, Volume: 50, Issue:7-8

    Topics: Alzheimer Disease; Cell Membrane; Glutamic Acid; Glutamine; Humans; Models, Neurological; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate

2007
Alterations of some membrane transport proteins in Alzheimer's disease: role of amyloid beta-peptide.
    Molecular bioSystems, 2008, Volume: 4, Issue:1

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Calcium Channels; Excitatory Amino Acid Transporter 2; Glutamine; Humans; Ion Transport; Membrane Transport Proteins; Models, Biological; Potassium Channels; Receptors, Cholinergic; Sodium-Potassium-Exchanging ATPase

2008
Cortical pyramidal neurone loss may cause glutamatergic hypoactivity and cognitive impairment in Alzheimer's disease: investigative and therapeutic perspectives.
    Journal of neurochemistry, 1993, Volume: 60, Issue:5

    Topics: Alzheimer Disease; Cerebral Cortex; Cognition Disorders; Glutamine; Histocytochemistry; Humans; Nerve Degeneration; Neurochemistry; Neurons

1993
[New therapeutic possibilities with low-affinity NMDA receptor antagonists].
    Der Nervenarzt, 1996, Volume: 67, Issue:1

    Topics: Aged; Alzheimer Disease; Amantadine; Antiparkinson Agents; Excitatory Amino Acid Antagonists; Glutamine; Humans; Memantine; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Receptors, Phencyclidine

1996
Drugs for treatment of Alzheimer's disease.
    International journal of clinical practice, 2001, Volume: 55, Issue:2

    Topics: Alzheimer Disease; Anti-Inflammatory Agents; Antiparkinson Agents; Cholinesterase Inhibitors; Estrogens; Glutamine; Humans; Memantine; Nerve Growth Factor; Neuroprotective Agents; Vaccines; Xanthines

2001
The treatment of cognitive impairment in Alzheimer's disease: beyond the cholinergic approach.
    The Psychiatric clinics of North America, 1991, Volume: 14, Issue:2

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Calcium Channel Blockers; Cholinergic Fibers; Cholinesterase Inhibitors; Cognition; Glutamine; Humans; Parasympathomimetics

1991
Glutamatergic abnormalities in Alzheimer's disease and a rationale for clinical trials with L-glutamate.
    Clinical neuropharmacology, 1988, Volume: 11, Issue:1

    Topics: Alzheimer Disease; Clinical Trials as Topic; Glutamates; Glutamine; Humans

1988

Trials

2 trial(s) available for glutamine and Alzheimer Disease

ArticleYear
Influence of the Glu298Asp polymorphism of NOS3 on age at onset and homocysteine levels in AD patients.
    Neurobiology of aging, 2005, Volume: 26, Issue:6

    Topics: Age Distribution; Age of Onset; Aged; Aged, 80 and over; Alzheimer Disease; Amino Acid Substitution; Female; Genetic Predisposition to Disease; Genetic Testing; Glutamine; Homocysteine; Humans; Italy; Male; Middle Aged; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Polymorphism, Genetic; Risk Assessment; Risk Factors; Statistics as Topic

2005
Glutamatergic abnormalities in Alzheimer's disease and a rationale for clinical trials with L-glutamate.
    Clinical neuropharmacology, 1988, Volume: 11, Issue:1

    Topics: Alzheimer Disease; Clinical Trials as Topic; Glutamates; Glutamine; Humans

1988

Other Studies

73 other study(ies) available for glutamine and Alzheimer Disease

ArticleYear
Hippocampal disruptions of synaptic and astrocyte metabolism are primary events of early amyloid pathology in the 5xFAD mouse model of Alzheimer's disease.
    Cell death & disease, 2021, 10-16, Volume: 12, Issue:11

    Topics: Alzheimer Disease; Amyloid; Animals; Astrocytes; Cerebral Cortex; Citric Acid Cycle; Disease Models, Animal; Energy Metabolism; Glucose; Glutamine; Glycolysis; Hippocampus; Male; Metabolome; Mice, Transgenic; Mitochondria; Neurotransmitter Agents; Proteome; Signal Transduction; Synapses

2021
Investigating Causal Relations Between Circulating Metabolites and Alzheimer's Disease: A Mendelian Randomization Study.
    Journal of Alzheimer's disease : JAD, 2022, Volume: 87, Issue:1

    Topics: Alzheimer Disease; Apolipoproteins B; Cholesterol; Genome-Wide Association Study; Glutamine; Humans; Mendelian Randomization Analysis; Polymorphism, Single Nucleotide; Risk Factors

2022
Design of Gallic Acid-Glutamine Conjugate and Chemical Implications for Its Potency Against Alzheimer's Amyloid-β Fibrillogenesis.
    Bioconjugate chemistry, 2022, 04-20, Volume: 33, Issue:4

    Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Gallic Acid; Glutamine; Humans; Molecular Dynamics Simulation; Peptide Fragments

2022
Phosphonate analog of 2-oxoglutarate regulates glutamate-glutamine homeostasis and counteracts amyloid beta induced learning and memory deficits in rats.
    Experimental gerontology, 2022, 10-15, Volume: 168

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Disease Models, Animal; Glutamate Dehydrogenase; Glutamate-Ammonia Ligase; Glutamates; Glutamine; Hippocampus; Homeostasis; Ketoglutarate Dehydrogenase Complex; Ketoglutaric Acids; Male; Maze Learning; Memory Disorders; Organophosphonates; Peptide Fragments; Rats; Rats, Wistar

2022
Promotion of astrocyte-neuron glutamate-glutamine shuttle by SCFA contributes to the alleviation of Alzheimer's disease.
    Redox biology, 2023, Volume: 62

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Astrocytes; Disease Models, Animal; Glutamates; Glutamine; Mice; Mice, Transgenic; Neurons

2023
A novel Alzheimer's disease prognostic signature: identification and analysis of glutamine metabolism genes in immunogenicity and immunotherapy efficacy.
    Scientific reports, 2023, 04-27, Volume: 13, Issue:1

    Topics: Alzheimer Disease; Biomarkers; Glutamine; Humans; Profilins; Prognosis

2023
Glutamine Supplementation Preserves Glutamatergic Neuronal Activity in the Infralimbic Cortex, Which Delays the Onset of Mild Cognitive Impairment in 3×Tg-AD Female Mice.
    Nutrients, 2023, Jun-19, Volume: 15, Issue:12

    Topics: Alzheimer Disease; Animals; Cognitive Dysfunction; Dietary Supplements; Disease Models, Animal; Female; Glutamine; Mice; Mice, Inbred C57BL; Mice, Transgenic; tau Proteins

2023
The causal role of circulating amino acids on neurodegenerative disorders: A two-sample Mendelian randomization study.
    Journal of neurochemistry, 2023, Volume: 166, Issue:6

    Topics: Alzheimer Disease; Amino Acids; Causality; Genome-Wide Association Study; Glutamine; Humans; Lewy Body Disease; Mendelian Randomization Analysis; Neurodegenerative Diseases; Parkinson Disease

2023
High-resolution metabolomic profiling of Alzheimer's disease in plasma.
    Annals of clinical and translational neurology, 2020, Volume: 7, Issue:1

    Topics: Aged; Aged, 80 and over; Alkaloids; Alzheimer Disease; Benzodioxoles; Biomarkers; Chromatography, Liquid; Cognitive Dysfunction; Female; Glutamine; Humans; Male; Mass Spectrometry; Metabolome; Metabolomics; Middle Aged; Piperidines; Polyunsaturated Alkamides

2020
Circulating Glutamine and Alzheimer's Disease: A Mendelian Randomization Study.
    Clinical interventions in aging, 2020, Volume: 15

    Topics: Aged; Alzheimer Disease; Blood-Brain Barrier; Brain; Cognition; Cognitive Dysfunction; Female; Genome-Wide Association Study; Glutamine; Humans; Male; Mendelian Randomization Analysis; Neuroprotective Agents; Receptors, Glutamate

2020
Glutamine Antagonist JHU-083 Normalizes Aberrant Hippocampal Glutaminase Activity and Improves Cognition in APOE4 Mice.
    Journal of Alzheimer's disease : JAD, 2020, Volume: 77, Issue:1

    Topics: Alzheimer Disease; Animals; Apolipoprotein E4; Azo Compounds; Caproates; Cell Line; Cells, Cultured; Cognition; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Glutaminase; Glutamine; Hippocampus; Humans; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia

2020
Hippocampal alterations in glutamatergic signaling during amyloid progression in AβPP/PS1 mice.
    Scientific reports, 2020, 09-02, Volume: 10, Issue:1

    Topics: Alzheimer Disease; Amyloid; Amyloid beta-Protein Precursor; Animals; Cognition; Glutamic Acid; Glutamine; Hippocampus; Male; Maze Learning; Memory; Mice; Mice, Inbred C57BL; Microelectrodes; Signal Transduction

2020
Deficient astrocyte metabolism impairs glutamine synthesis and neurotransmitter homeostasis in a mouse model of Alzheimer's disease.
    Neurobiology of disease, 2021, Volume: 148

    Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Astrocytes; Carbon Isotopes; Disease Models, Animal; gamma-Aminobutyric Acid; Gas Chromatography-Mass Spectrometry; Glutamic Acid; Glutamine; Hippocampus; Homeostasis; Mice; Mice, Transgenic; Neurotransmitter Agents; Presenilin-1

2021
High performance liquid chromatography determination of L-glutamate, L-glutamine and glycine content in brain, cerebrospinal fluid and blood serum of patients affected by Alzheimer's disease.
    Amino acids, 2021, Volume: 53, Issue:3

    Topics: Aged, 80 and over; Alzheimer Disease; Biomarkers; Chromatography, High Pressure Liquid; Female; Glutamic Acid; Glutamine; Glycine; Humans; Male; Prefrontal Cortex

2021
Downregulation of GABA Transporter 3 (GAT3) is Associated with Deficient Oxidative GABA Metabolism in Human Induced Pluripotent Stem Cell-Derived Astrocytes in Alzheimer's Disease.
    Neurochemical research, 2021, Volume: 46, Issue:10

    Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Astrocytes; Down-Regulation; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Induced Pluripotent Stem Cells; Mutation; Presenilin-1

2021
Small-World Networks and Their Relationship With Hippocampal Glutamine/Glutamate Concentration in Healthy Adults With Varying Genetic Risk for Alzheimer's Disease.
    Journal of magnetic resonance imaging : JMRI, 2021, Volume: 54, Issue:3

    Topics: Adult; Alzheimer Disease; Brain; Glutamic Acid; Glutamine; Hippocampus; Humans; Magnetic Resonance Imaging; Prospective Studies

2021
Editorial for "Small-World Networks and Their Relationship With Hippocampal Glutamine/Glutamate (Glx) Concentration in Healthy Adults With Varying Genetic Risk for Alzheimer's Disease".
    Journal of magnetic resonance imaging : JMRI, 2021, Volume: 54, Issue:3

    Topics: Adult; Alzheimer Disease; Glutamic Acid; Glutamine; Hippocampus; Humans; Magnetic Resonance Spectroscopy

2021
Decreased Glucose Metabolism and Glutamine Synthesis in the Retina of a Transgenic Mouse Model of Alzheimer's Disease.
    Cellular and molecular neurobiology, 2022, Volume: 42, Issue:1

    Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Disease Models, Animal; Female; Glucose; Glutamine; Humans; Mice; Mice, Transgenic; Retina

2022
Amalaki Rasayana improved memory and neuronal metabolic activity in AbPP-PS1 mouse model of Alzheimer's disease.
    Journal of biosciences, 2017, Volume: 42, Issue:3

    Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Brain; Carbon Isotopes; Cognition; Donepezil; gamma-Aminobutyric Acid; Gene Expression; Glucose; Glutamic Acid; Glutamine; Humans; Indans; Male; Maze Learning; Medicine, Ayurvedic; Memory; Mice; Mice, Transgenic; Neurons; Neuroprotective Agents; Piperidines; Plant Extracts; Presenilin-1

2017
Early Activation of Astrocytes does not Affect Amyloid Plaque Load in an Animal Model of Alzheimer's Disease.
    Neuroscience bulletin, 2018, Volume: 34, Issue:6

    Topics: Aldehyde Dehydrogenase; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Astrocytes; Brain; Calcium-Binding Proteins; Cell Proliferation; Disease Models, Animal; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Glutamine; Green Fluorescent Proteins; Humans; Ki-67 Antigen; Mice; Mice, Transgenic; Microfilament Proteins; Mutation; Nerve Tissue Proteins; Oxidoreductases Acting on CH-NH Group Donors

2018
Ceftriaxone Improves Cognitive Function and Upregulates GLT-1-Related Glutamate-Glutamine Cycle in APP/PS1 Mice.
    Journal of Alzheimer's disease : JAD, 2018, Volume: 66, Issue:4

    Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Anti-Bacterial Agents; Ceftriaxone; Cognition; Disease Models, Animal; Excitatory Amino Acid Transporter 2; Glutamic Acid; Glutamine; Hippocampus; Maze Learning; Mice; Mice, Transgenic; Presenilin-1; Up-Regulation

2018
Clinical and Pathological Benefit of Twendee X in Alzheimer's Disease Transgenic Mice with Chronic Cerebral Hypoperfusion.
    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2019, Volume: 28, Issue:7

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Anti-Inflammatory Agents; Antioxidants; Ascorbic Acid; Behavior, Animal; Brain; Cerebrovascular Circulation; Cerebrovascular Disorders; Chronic Disease; Cognition; Cystine; Dietary Supplements; Disease Models, Animal; Female; Glutamine; Inflammation Mediators; Male; Mice, Inbred C57BL; Mice, Transgenic; Motor Activity; Mutation; Neuroprotective Agents; Oxidative Stress; Plaque, Amyloid

2019
Twendee X Ameliorates Phosphorylated Tau, α-Synuclein and Neurovascular Dysfunction in Alzheimer's Disease Transgenic Mice With Chronic Cerebral Hypoperfusion.
    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2019, Volume: 28, Issue:10

    Topics: alpha-Synuclein; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Antioxidants; Ascorbic Acid; Brain; Cerebrovascular Disorders; Cystine; Dietary Supplements; Disease Models, Animal; Female; Genetic Predisposition to Disease; Glutamine; Male; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Neurovascular Coupling; Phenotype; Phosphorylation; tau Proteins

2019
R-flurbiprofen improves tau, but not Aß pathology in a triple transgenic model of Alzheimer's disease.
    Brain research, 2013, Dec-06, Volume: 1541

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Flurbiprofen; Glutamic Acid; Glutamine; Hippocampus; Humans; Immunohistochemistry; Magnetic Resonance Spectroscopy; Maze Learning; Mice; Mice, Transgenic; tau Proteins

2013
Reversal of metabolic deficits by lipoic acid in a triple transgenic mouse model of Alzheimer's disease: a 13C NMR study.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2014, Volume: 34, Issue:2

    Topics: Alzheimer Disease; Animals; Aspartic Acid; Biomarkers; Citric Acid Cycle; gamma-Aminobutyric Acid; Glucose; Glutamic Acid; Glutamine; Humans; Mice; Mice, Transgenic; Thioctic Acid; Vitamin B Complex

2014
Neuronal and astrocytic metabolism in a transgenic rat model of Alzheimer's disease.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2014, Volume: 34, Issue:5

    Topics: Alzheimer Disease; Animals; Astrocytes; Brain; Citric Acid Cycle; Disease Models, Animal; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Neurons; Pyruvic Acid; Rats; Rats, Transgenic; Rats, Wistar

2014
Plasma metabolite profiles of Alzheimer's disease and mild cognitive impairment.
    Journal of proteome research, 2014, May-02, Volume: 13, Issue:5

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Arachidonic Acid; Biomarkers; Chromatography, Liquid; Cognitive Dysfunction; Cytidine; Gas Chromatography-Mass Spectrometry; Glutamic Acid; Glutamine; Humans; Male; Mass Spectrometry; Metabolomics; Middle Aged; Reproducibility of Results; Sarcosine; Sensitivity and Specificity; Thymine

2014
A commonly used Drosophila model of Alzheimer's disease generates an aberrant species of amyloid-β with an additional N-terminal glutamine residue.
    FEBS letters, 2014, Oct-16, Volume: 588, Issue:20

    Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Animals; Drosophila; Glutamine; Molecular Sequence Data; Peptide Fragments; Phenotype; Protein Sorting Signals; Protein Structure, Tertiary

2014
¹H- and ¹³C-NMR spectroscopy of Thy-1-APPSL mice brain extracts indicates metabolic changes in Alzheimer's disease.
    Journal of neural transmission (Vienna, Austria : 1996), 2015, Volume: 122, Issue:4

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Brain; Carbon-13 Magnetic Resonance Spectroscopy; Creatine; Disease Models, Animal; Female; gamma-Aminobutyric Acid; Glucose; Glutamic Acid; Glutamine; Humans; Inositol; Male; Mice, Transgenic; Mutation; Peptide Fragments; Phosphorylcholine; Proton Magnetic Resonance Spectroscopy

2015
Glutamine and Glutamate Complex, as Measured by Functional Magnetic Resonance Spectroscopy, Alters During Face-Name Association Task in Patients with Mild Cognitive Impairment and Alzheimer's Disease.
    Journal of Alzheimer's disease : JAD, 2016, 03-05, Volume: 52, Issue:1

    Topics: Adult; Aged; Alzheimer Disease; Brain; Brain Mapping; Cognitive Dysfunction; Cohort Studies; Face; Female; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Mental Status Schedule; Names; Neuropsychological Tests; Pattern Recognition, Physiological; ROC Curve

2016
The impact of glutamine supplementation on the symptoms of ataxia-telangiectasia: a preclinical assessment.
    Molecular neurodegeneration, 2016, 08-18, Volume: 11, Issue:1

    Topics: Alzheimer Disease; Animals; Ataxia Telangiectasia; Blood Glucose; Cell Cycle Proteins; Disease Models, Animal; DNA-Binding Proteins; Glutamine; Mice, Knockout; Neurons; Neuroprotective Agents

2016
Whole-brain patterns of (1)H-magnetic resonance spectroscopy imaging in Alzheimer's disease and dementia with Lewy bodies.
    Translational psychiatry, 2016, 08-30, Volume: 6, Issue:8

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain; Case-Control Studies; Choline; Creatine; Female; Glutamic Acid; Glutamine; Humans; Inositol; Lewy Body Disease; Magnetic Resonance Imaging; Male; Proton Magnetic Resonance Spectroscopy

2016
Glutamate-glutamine and GABA in brain of normal aged and patients with cognitive impairment.
    European radiology, 2017, Volume: 27, Issue:7

    Topics: Adult; Aged; Aging; Alzheimer Disease; Analysis of Variance; Case-Control Studies; Cognitive Dysfunction; Early Diagnosis; Female; gamma-Aminobutyric Acid; Glutamates; Glutamine; Gyrus Cinguli; Hippocampus; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Young Adult

2017
Altered splicing in exon 8 of the DNA replication factor CIZ1 affects subnuclear distribution and is associated with Alzheimer's disease.
    Molecular and cellular neurosciences, 2008, Volume: 38, Issue:4

    Topics: Alternative Splicing; Alzheimer Disease; Amino Acid Sequence; Animals; Cell Line; Cell Line, Tumor; DNA Replication; Exons; Glutamine; Humans; Intranuclear Space; Male; Mice; Molecular Sequence Data; Nuclear Proteins; Protein Isoforms; Salmon

2008
Lateralization of hippocampal nitric oxide mediator system in people with Alzheimer disease, multi-infarct dementia and schizophrenia.
    Neurochemistry international, 2008, Volume: 53, Issue:5

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Arginine; Citrulline; Dementia, Multi-Infarct; Female; Functional Laterality; Glutamine; Hippocampus; Humans; Isoenzymes; Male; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Schizophrenia; Signal Transduction

2008
Conversion to dementia in mild cognitive impairment is associated with decline of N-actylaspartate and creatine as revealed by magnetic resonance spectroscopy.
    Psychiatry research, 2009, Jul-15, Volume: 173, Issue:1

    Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain; Choline; Cognition; Cognition Disorders; Creatine; Dementia; Disease Progression; Female; Follow-Up Studies; Glutamine; Humans; Inositol; Longitudinal Studies; Magnetic Resonance Spectroscopy; Male; Memory; Middle Aged; Parietal Lobe; Prognosis; Severity of Illness Index

2009
Glutaminyl cyclases display significant catalytic proficiency for glutamyl substrates.
    Biochemistry, 2009, Dec-22, Volume: 48, Issue:50

    Topics: Alzheimer Disease; Aminoacyltransferases; Amyloid; Animals; Catalysis; Cyclization; Glutamine; Humans; Substrate Specificity

2009
Reactive astrocytes give neurons less support: implications for Alzheimer's disease.
    Neurobiology of aging, 2012, Volume: 33, Issue:2

    Topics: Alzheimer Disease; Animals; Astrocytes; Brain; Cell Communication; Glucose; Glutamic Acid; Glutamine; Humans; Models, Neurological; Neurons

2012
Familial prion disease with Alzheimer disease-like tau pathology and clinical phenotype.
    Annals of neurology, 2011, Volume: 69, Issue:4

    Topics: Adult; Aged; Alzheimer Disease; Codon, Nonsense; Depressive Disorder, Major; Female; Glutamine; Humans; Memory Disorders; Memory, Short-Term; Middle Aged; Neurofibrillary Tangles; Neuropsychological Tests; Phenotype; Prion Diseases; Prion Proteins; Prions; tau Proteins; Tyrosine

2011
N-acetylaspartate, choline, myoinositol, glutamine and glutamate (glx) concentration changes in proton MR spectroscopy (1H MRS) in patients with mild cognitive impairment (MCI).
    Medical science monitor : international medical journal of experimental and clinical research, 2011, Volume: 17, Issue:12

    Topics: Aged; Alzheimer Disease; Aspartic Acid; Choline; Cognitive Dysfunction; Disease Progression; Female; Glutamic Acid; Glutamine; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Middle Aged; Protons; Temporal Lobe

2011
Glutamine acts as a neuroprotectant against DNA damage, beta-amyloid and H2O2-induced stress.
    PloS one, 2012, Volume: 7, Issue:3

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cell Line; Cell Survival; Disease Models, Animal; DNA Damage; Gene Expression; Glutamate-Ammonia Ligase; Glutamine; Hippocampus; Humans; Hydrogen Peroxide; Mice; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Stress, Physiological

2012
Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part I: creatine kinase BB, glutamine synthase, and ubiquitin carboxy-terminal hydrolase L-1.
    Free radical biology & medicine, 2002, Aug-15, Volume: 33, Issue:4

    Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Antibodies, Monoclonal; Blotting, Western; Brain Chemistry; Creatine Kinase; Creatine Kinase, BB Form; Electrophoresis, Gel, Two-Dimensional; Free Radicals; Glutamate-Ammonia Ligase; Glutamic Acid; Glutamine; Humans; Image Processing, Computer-Assisted; Isoenzymes; Nerve Degeneration; Nerve Tissue Proteins; Oxidation-Reduction; Proteomics; Rosaniline Dyes; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Staining and Labeling; Thiolester Hydrolases; Ubiquitin Thiolesterase

2002
Proton MR spectroscopy in mild cognitive impairment and Alzheimer disease: comparison of 1.5 and 3 T.
    AJNR. American journal of neuroradiology, 2003, Volume: 24, Issue:5

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain; Choline; Cognition Disorders; Creatine; Female; Glutamine; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Middle Aged; ROC Curve

2003
Methionine synthase polymorphism is a risk factor for Alzheimer disease.
    Neuroreport, 2003, Jul-18, Volume: 14, Issue:10

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Age of Onset; Aged; Aged, 80 and over; Aging; Alanine; Alzheimer Disease; Apolipoproteins E; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Glutamine; Humans; Logistic Models; Male; Middle Aged; Mutation; Polymorphism, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Risk Factors; RNA, Messenger; Sex Characteristics

2003
Two novel presenilin-1 mutations (Y256S and Q222H) are associated with early-onset Alzheimer's disease.
    Neurobiology of aging, 2003, Volume: 24, Issue:5

    Topics: Adult; Alzheimer Disease; Amino Acid Substitution; Amyloid beta-Peptides; Blotting, Western; Brain; DNA Mutational Analysis; Enzyme-Linked Immunosorbent Assay; Family Health; Female; Glutamine; Histidine; Humans; Immunohistochemistry; Membrane Proteins; Mutation, Missense; Pedigree; Peptide Fragments; Plaque, Amyloid; Presenilin-1; Serine; Tyrosine

2003
Cross-linking of ubiquitin, HSP27, parkin, and alpha-synuclein by gamma-glutamyl-epsilon-lysine bonds in Alzheimer's neurofibrillary tangles.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2004, Volume: 18, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; alpha-Synuclein; Alzheimer Disease; Brain Chemistry; Cerebral Cortex; Chromatography, High Pressure Liquid; Dipeptides; Enzyme-Linked Immunosorbent Assay; Female; Glutamine; Heat-Shock Proteins; Hippocampus; HSP27 Heat-Shock Proteins; Humans; Inclusion Bodies; Lysine; Macromolecular Substances; Male; Molecular Chaperones; Neoplasm Proteins; Nerve Tissue Proteins; Neurofibrillary Tangles; Neurofilament Proteins; Plaque, Amyloid; Proteasome Endopeptidase Complex; Solubility; Synucleins; tau Proteins; Ubiquitin; Ubiquitin-Protein Ligases

2004
Cerebrospinal fluid from patients with dementia contains increased amounts of an unknown factor.
    Journal of neuroscience research, 2004, Oct-15, Volume: 78, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Case-Control Studies; Choline; Dementia, Vascular; Female; Glutamine; Humans; Huntington Disease; Magnetic Resonance Spectroscopy; Male; Middle Aged; Parkinson Disease

2004
Amino acids and transaminases activity in ventricular CSF and in brain of normal and Alzheimer patients.
    Neuroscience letters, 2005, Nov-04, Volume: 388, Issue:1

    Topics: Aged; Aged, 80 and over; Alanine Transaminase; Alzheimer Disease; Amino Acids; Aspartate Aminotransferases; Aspartic Acid; Brain; Brain Chemistry; Cerebrospinal Fluid; Female; Glutamic Acid; Glutamine; Humans; Lateral Ventricles; Male; Middle Aged; Reference Values; Transaminases; Up-Regulation

2005
Beta-amyloid treatment sensitizes mice to amphetamine-induced locomotion but reduces response to caffeine.
    Neuro-degenerative diseases, 2004, Volume: 1, Issue:1

    Topics: Adenosine; Adrenergic Agents; Alzheimer Disease; Amphetamine; Amyloid beta-Peptides; Animals; Avoidance Learning; Brain; Caffeine; Central Nervous System Stimulants; Disease Models, Animal; Dizocilpine Maleate; Dopamine; Excitatory Amino Acid Antagonists; Glutamine; Injections, Intraventricular; Male; Mice; Motor Activity; Psychotic Disorders

2004
Polyglutamine expansion mutation yields a pathological epitope linked to nucleation of protein aggregate: determinant of Huntington's disease onset.
    PloS one, 2007, Jul-25, Volume: 2, Issue:7

    Topics: Age of Onset; Alzheimer Disease; Cell Death; DNA; DNA Primers; DNA Repeat Expansion; Genes, Reporter; Glutamine; Humans; Huntington Disease; Kinetics; Mutation; Parkinson Disease; Peptides; Plasmids; Polylysine; Polymerase Chain Reaction; Transfection

2007
Genetic analysis of tumor necrosis factor-alpha (TNF-alpha) G-308A and Saitohin Q7R polymorphisms with Alzheimer's disease.
    Journal of the neurological sciences, 2008, Jul-15, Volume: 270, Issue:1-2

    Topics: Aged; Alzheimer Disease; Apolipoprotein E4; Arginine; Chi-Square Distribution; China; Female; Gene Frequency; Genetic Predisposition to Disease; Genetic Testing; Genotype; Glutamine; Humans; Male; Polymorphism, Genetic; tau Proteins; Tumor Necrosis Factor-alpha

2008
Role of the familial Dutch mutation E22Q in the folding and aggregation of the 15-28 fragment of the Alzheimer amyloid-beta protein.
    Proceedings of the National Academy of Sciences of the United States of America, 2008, Apr-22, Volume: 105, Issue:16

    Topics: Alzheimer Disease; Amino Acid Motifs; Amino Acid Sequence; Amino Acid Substitution; Amyloid beta-Peptides; Entropy; Glutamic Acid; Glutamine; Humans; Molecular Sequence Data; Mutation, Missense; Netherlands; Peptide Fragments; Protein Conformation; Protein Folding; White People

2008
Alterations in metabolic properties in fibroblasts in Alzheimer disease.
    Alzheimer disease and associated disorders, 1995,Summer, Volume: 9, Issue:2

    Topics: Aged; Alzheimer Disease; Blood Glucose; Chromosome Aberrations; Chromosome Disorders; Energy Metabolism; Female; Fibroblasts; Genes, Dominant; Glutamine; Humans; Lactates; Lactic Acid; Male; Middle Aged; Reference Values

1995
Identification of glutamine and lysine residues in Alzheimer amyloid beta A4 peptide responsible for transglutaminase-catalysed homopolymerization and cross-linking to alpha 2M receptor.
    FEBS letters, 1994, Jan-31, Volume: 338, Issue:2

    Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Binding Sites; Chromatography, High Pressure Liquid; Cross-Linking Reagents; Extracellular Matrix Proteins; Glutamine; Low Density Lipoprotein Receptor-Related Protein-1; Lysine; Molecular Sequence Data; Polymers; Receptors, Immunologic; Structure-Activity Relationship; Transglutaminases

1994
Cross-linking of a synthetic partial-length (1-28) peptide of the Alzheimer beta/A4 amyloid protein by transglutaminase.
    FEBS letters, 1993, Jul-12, Volume: 326, Issue:1-3

    Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Cross-Linking Reagents; Electrophoresis, Polyacrylamide Gel; Glutamine; Humans; Lysine; Molecular Sequence Data; Peptide Fragments; Transglutaminases

1993
Excessive glutamine sensitivity in Alzheimer's disease and Down syndrome lymphocytes.
    Journal of the neurological sciences, 1995, Volume: 133, Issue:1-2

    Topics: Adult; Alzheimer Disease; Case-Control Studies; Cells, Cultured; Down Syndrome; Female; Glutamine; Humans; Lymphocytes; Male; Middle Aged; Mitotic Index

1995
Enhanced pathologic properties of Dutch-type mutant amyloid beta-protein.
    Proceedings of the National Academy of Sciences of the United States of America, 1996, Apr-02, Volume: 93, Issue:7

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloidosis; Cell Survival; Cells, Cultured; Cerebral Hemorrhage; Glutamic Acid; Glutamine; Humans; Kinetics; Meninges; Muscle, Smooth, Vascular; Netherlands; Peptide Fragments; Point Mutation

1996
CSF excitatory amino acids and severity of illness in Alzheimer's disease.
    Neurology, 1996, Volume: 46, Issue:6

    Topics: Aged; Alzheimer Disease; Aspartic Acid; Glutamine; Humans; Middle Aged; Neuropsychological Tests; Severity of Illness Index; Taurine

1996
Frontotemporal dementia and early Alzheimer disease: differentiation with frontal lobe H-1 MR spectroscopy.
    Radiology, 1997, Volume: 203, Issue:3

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Dementia; Discriminant Analysis; Female; Frontal Lobe; Glutamic Acid; Glutamine; Humans; Hydrogen; Inositol; Lactates; Linear Models; Magnetic Resonance Spectroscopy; Male; Middle Aged; Nerve Degeneration; Neuroglia; Neurons; Parietal Lobe; Protons; Sensitivity and Specificity; Temporal Lobe

1997
[Clinical uses of proton magnetic resonance spectroscopy of the brain].
    RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin, 1998, Volume: 168, Issue:6

    Topics: AIDS Dementia Complex; Alzheimer Disease; Animals; Aspartic Acid; Brain; Brain Diseases; Brain Diseases, Metabolic; Child; Choline; Creatine; Glutamine; Hepatic Encephalopathy; Humans; Inositol; Leukoencephalopathy, Progressive Multifocal; Magnetic Resonance Spectroscopy; Male; Middle Aged; Protons; Rats

1998
Abnormal substrate levels that depend upon mitochondrial function in cerebrospinal fluid from Alzheimer patients.
    Gerontology, 1998, Volume: 44, Issue:5

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cerebrospinal Fluid; Citric Acid Cycle; Female; Fumarates; Glutamine; Humans; Lactic Acid; Male; Mitochondria; Reference Values; Substrate Specificity; Succinic Acid

1998
Presynaptic nicotinic acetylcholine receptors as a functional target of nefiracetam in inducing a long-lasting facilitation of hippocampal neurotransmission.
    Alzheimer disease and associated disorders, 2000, Volume: 14 Suppl 1

    Topics: Acetylcholine; Alzheimer Disease; Animals; Cognition Disorders; Electrophysiology; Glutamine; Hippocampus; Nootropic Agents; Oocytes; Protein Kinase C; Pyrrolidinones; Receptors, Nicotinic; Synaptic Transmission; Xenopus

2000
Copper catalyzed oxidation of Alzheimer Abeta.
    Cellular and molecular biology (Noisy-le-Grand, France), 2000, Volume: 46, Issue:4

    Topics: Alzheimer Disease; Amino Acids; Amyloid beta-Peptides; Arginine; Catalysis; Chromatography, High Pressure Liquid; Copper; Glutamic Acid; Glutamine; Histidine; Humans; Hydrogen Peroxide; Iron; Oxidation-Reduction; Oxygen; Peptide Fragments; Protein Processing, Post-Translational; Time Factors; Tyrosine

2000
Decreased glutamate + glutamine in Alzheimer's disease detected in vivo with (1)H-MRS at 0.5 T.
    Neurology, 2001, Mar-27, Volume: 56, Issue:6

    Topics: Activities of Daily Living; Aged; Aged, 80 and over; Alzheimer Disease; Brain; Female; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Protons

2001
Proton MR spectroscopic study at 3 Tesla on glutamate/glutamine in Alzheimer's disease.
    Neuroreport, 2002, Jan-21, Volume: 13, Issue:1

    Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain; Creatine; Female; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Phosphocreatine; Reference Values; Tissue Distribution

2002
Amyloid fibers are water-filled nanotubes.
    Proceedings of the National Academy of Sciences of the United States of America, 2002, Apr-16, Volume: 99, Issue:8

    Topics: Alzheimer Disease; Amyloid; Asparagine; Crystallography, X-Ray; Exons; Fourier Analysis; Fungal Proteins; Glutamine; Humans; Huntingtin Protein; Hydrogen Bonding; Microscopy, Electron; Nerve Tissue Proteins; Nuclear Proteins; Peptide Termination Factors; Peptides; Prions; Protein Structure, Secondary; Saccharomyces cerevisiae Proteins

2002
N-acetyl-L-aspartate and other amino acid metabolites in Alzheimer's disease brain: a preliminary proton nuclear magnetic resonance study.
    Neurology, 1992, Volume: 42, Issue:8

    Topics: Aged; Alzheimer Disease; Amino Acids; Aspartic Acid; Brain; Cadaver; Female; Glutamates; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Male

1992
Framing beta-amyloid.
    Nature genetics, 1992, Volume: 1, Issue:4

    Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Brain; Cerebrovascular Disorders; Codon; Genotype; Glutamates; Glutamic Acid; Glutamine; Humans; Molecular Sequence Data; Mutation; Phenotype; Protein Structure, Secondary

1992
Peptides homologous to the amyloid protein of Alzheimer's disease containing a glutamine for glutamic acid substitution have accelerated amyloid fibril formation.
    Biochemical and biophysical research communications, 1991, Sep-30, Volume: 179, Issue:3

    Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Glutamates; Glutamic Acid; Glutamine; Microscopy, Electron; Microscopy, Immunoelectron; Molecular Sequence Data; Mutation; Myofibrils; Peptides

1991
Topographical distribution of neurochemical changes in Alzheimer's disease.
    Journal of the neurological sciences, 1988, Volume: 84, Issue:2-3

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amino Acids, Dicarboxylic; Asparagine; Aspartic Acid; Cerebellar Cortex; Cerebral Cortex; Choline O-Acetyltransferase; Glutamates; Glutaminase; Glutamine; Humans; Middle Aged; Somatostatin

1988
Self assembly of microtubule associated protein tau into filaments resembling those found in Alzheimer disease.
    Biochemical and biophysical research communications, 1986, Dec-15, Volume: 141, Issue:2

    Topics: Alzheimer Disease; Animals; Glutamates; Glutaminase; Glutamine; Macromolecular Substances; Microtubule-Associated Proteins; Neurofibrils; Peptide Fragments; Polymers; Protein Binding; Swine; tau Proteins

1986
Evidence of glutamatergic denervation and possible abnormal metabolism in Alzheimer's disease.
    Journal of neurochemistry, 1988, Volume: 50, Issue:3

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amino Acids; Brain; Glutaminase; Glutamine; Humans; Phosphates; Time Factors

1988
Alterations in calcium content and biochemical processes in cultured skin fibroblasts from aged and Alzheimer donors.
    Proceedings of the National Academy of Sciences of the United States of America, 1986, Volume: 83, Issue:8

    Topics: Adult; Aging; Alzheimer Disease; Calcium; Cells, Cultured; DNA; Female; Glucose; Glutamine; Humans; Male; Middle Aged; Mitochondria; Protein Biosynthesis; Skin

1986