Compounds > glutamine

glutamine and Adenocarcinoma Of Kidney

glutamine has been researched along with Adenocarcinoma Of Kidney in 30 studies

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (3.33)29.6817
2010's14 (46.67)24.3611
2020's15 (50.00)2.80

Authors

AuthorsStudies
Chen, J; Dang, R; Emberley, E; Gross, M; Huang, T; Li, W; MacKinnon, A; Pan, A; Parlati, F; Singh, D; Sotirovska, N; Steggerda, SM; Wang, T1
Enokida, H; Fukumoto, W; Inoguchi, S; Kawakami, I; Matsushita, R; Nakagawa, M; Okamura, S; Osako, Y; Sakaguchi, T; Tamai, M; Tatarano, S; Yamada, Y; Yoshino, H1
Akella, L; Bendell, J; Emamekhoo, H; Fan, AC; Gartrell, BA; Goodman, OB; Hsieh, JJ; Hussain, A; Kalebasty, AR; Lee, CH; Liu, S; Matrana, M; McCune, S; Motzer, R; Nikolinakos, PG; Orford, K; Parmar, H; Patel, V; Percent, I; Shaheen, M; Tannir, NM; Vaishampayan, U; Zakharia, Y; Zhang, Z1
Becker, M; Bedke, J; Büttner, FA; Fend, F; Haag, M; Hennenlotter, J; Hofmann, U; Klumpp, V; Leuthold, P; Menig, LS; Rausch, S; Reustle, A; Schaeffeler, E; Scharpf, M; Schmees, C; Schwab, M; Stenzl, A; Stühler, V; Winter, S1
Agarwal, N; Akella, L; Appleman, LJ; Davis, N; Escudier, B; Figlin, R; Gandhi, S; Geynisman, DM; Goodman, O; Iacovelli, R; Jain, RK; Lawrence, NJ; Lee, RJ; McGregor, B; Mellado, B; Motzer, R; Orford, K; Porta, C; Powles, T; Sepúlveda Sánchez, JM; Stadler, WM; Tannir, NM1
Dankó, T; Krencz, I; Mészáros, K; Moldvai, D; Pápay, J; Petővári, G; Raffay, R; Sebestyén, A; Sebestyén, E; Sztankovics, D; Végső, G; Vetlényi, E1
Wang, L; Wang, Y; Wu, J; Yang, L1
Ahumada, K; Boroughs, LK; Brugarolas, J; Cai, F; Chiang, JC; DeBerardinis, RJ; Do, QN; Faubert, B; Genovese, G; Kapur, P; Kaushik, AK; Li, X; Mathews, TP; Merritt, M; Pachnis, P; Ragavan, M; Rao, AD; Rosales, T; Saatchi, F; Slusher, BS; Stevens, C; Sun, X; Tarangelo, A; Tcheuyap, VT; Vu, H; Wu, CY; Yong, C; Zacharias, LG; Zhang, Y1
Wang, M1
Chen, H; Deng, Z; Huang, K; Liang, H; Wu, K; Wu, R1
He, B; He, CJ; Jiang, H; Li, AM; Li, Y; Ye, J; Zhou, MN1
Eichelmann, H; Eskla, KL; Hüva, A; Jagomäe, T; Laisk, A; Luuk, H; Oja, V; Porosk, R; Rämma, H; Roberts, J; Tennant, DA; Thakker, A; Vasar, E; Vellama, H; Volke, V1
Baltazar, F; Henrique, R; Jerónimo, C; Lameirinhas, A; Miranda-Gonçalves, V1
Abraham, A; Ali, A; Bader, JE; Beckermann, KE; Brown, RE; Chytil, A; Cohen, AS; Do, BT; Hongo, RA; Huffstater, T; Johnson, RW; Lewis, CA; Madden, MZ; Manning, HC; Mason, EF; Mason, FM; Merryman, WD; Muir, A; O'Neil, RT; Patterson, AR; Rathmell, JC; Rathmell, WK; Reinfeld, BI; Sugiura, A; Tantawy, MN; Todd, VM; Vander Heiden, MG; Williams, CS; Wilson, MH; Wolf, MM; Xin, F; Young, KL1
Guan, X; Guo, L; Kai, J; Liu, Y; Lu, R; Tong, Y; Wang, S; Wang, Y; Xie, S; Yu, Y; Zheng, H; Zhu, K1
Chaves, F; Christodoulou, D; Gameiro, PA; Iliopoulos, O; Laviollette, L; Lee, R; Okazaki, A; Schneider, M; Stemmer-Rachamimov, A; Stephanopoulos, G; Yazinski, SA; Zou, L1
Abu Aboud, O; Chaudhari, AJ; Habib, SL; Liang, S; Stewart, B; Sutcliffe, J; Trott, J; Weiss, RH1
Weiss, RH1
Chang, Y; Dai, B; Fu, H; Fu, Q; Hu, B; Jiang, Q; Liu, Z; Qi, Y; Tong, S; Wang, T; Wang, Y; Xie, H; Xu, J; Xu, L; Zeng, H; Zhang, J; Zhang, W; Zhou, L; Zhou, Q; Zhu, Y1
Acker, T; Aragonés, J; Böğürcü-Seidel, N; Bouthelier, A; De Bock, K; Elorza, A; Escasany, E; Fendt, SM; Fraga, E; Fuertes, E; Giménez-Bachs, JM; Hernansanz-Agustín, P; Li, QOY; Lorendeau, D; Martínez-Ruiz, A; Meléndez-Rodríguez, F; Mesa-Ciller, C; Ortega Muelas, M; Pérez, B; Rinaldi, G; Roche, O; Salinas-Sánchez, AS; Sánchez Prieto, R; Tello, D; Torres-Capelli, M; Turiel, G; Urrutia, AA1
Arreola, A; Baker, R; Gameiro, PA; Iliopoulos, O; López-Larrubia, P; Metelo, AM; Olumi, A; Pérez-Carro, R; Rathmell, WK; Stephanopoulos, G; Wang, Z; Yang, J1
Desimone, MC; Rathmell, WK; Threadgill, DW1
Adam, SJ; Bellovin, DI; Casey, SC; Dang, CV; Dang, VM; Eberlin, LS; Felsher, DW; Gabay, M; Garcia-Ocana, A; Gouw, AM; Li, Y; Philbrick, WM; Shroff, EH; Tran, PT; Zare, RN1
Felsher, DW; Gouw, AM; Toal, GG1
Crooks, DR; Linehan, WM; Ricketts, CJ; Schmidt, LS; Sourbier, C; Srinivasan, R1
Choi, J; Choi, KH; Han, WK; Kang, HG; Kim, KS; Koh, E; Lee, HW; Lee, YS; Yoon, YE1
Chatterjee, A; Foster, DA; Mroz, V; Ohh, M; Patel, D; Salloum, D; Saqcena, M1
Chandel, NS; Chen, PH; Cheng, T; DeBerardinis, RJ; Jin, ES; Linehan, WM; Mullen, AR; Sullivan, LB; Wheaton, WW; Yang, Y1
Bell, EL; Gameiro, PA; Guarente, L; Hiller, K; Iliopoulos, O; Irvine, DJ; Jewell, CM; Johnson, ZR; Kelleher, JK; Mattaini, KR; Metallo, CM; Stephanopoulos, G; Vander Heiden, MG; Yang, J1
Joshi, BH; Puri, RK1

Reviews

2 review(s) available for glutamine and Adenocarcinoma Of Kidney

ArticleYear
The metabolic landscape of urological cancers: New therapeutic perspectives.
    Cancer letters, 2020, 05-01, Volume: 477

    Topics: Carcinoma, Renal Cell; Glucose; Glutamine; Humans; Kidney Neoplasms; Lipid Metabolism; Male; Prostatic Neoplasms; Urologic Neoplasms

2020
Metabolomics and Metabolic Reprogramming in Kidney Cancer.
    Seminars in nephrology, 2018, Volume: 38, Issue:2

    Topics: Adaptation, Physiological; Arginine; Carcinoma, Renal Cell; Fatty Acids; Glutamine; Glycolysis; Humans; Kidney Neoplasms; Lipids; Metabolic Networks and Pathways; Metabolomics; Tryptophan

2018

Trials

1 trial(s) available for glutamine and Adenocarcinoma Of Kidney

ArticleYear
Telaglenastat plus Everolimus in Advanced Renal Cell Carcinoma: A Randomized, Double-Blinded, Placebo-Controlled, Phase II ENTRATA Trial.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2022, 08-02, Volume: 28, Issue:15

    Topics: Angiogenesis Inhibitors; Carcinoma, Renal Cell; Everolimus; Glutaminase; Glutamine; Humans; Kidney Neoplasms; Protein Kinase Inhibitors; Sirolimus

2022

Other Studies

27 other study(ies) available for glutamine and Adenocarcinoma Of Kidney

ArticleYear
The glutaminase inhibitor telaglenastat enhances the antitumor activity of signal transduction inhibitors everolimus and cabozantinib in models of renal cell carcinoma.
    PloS one, 2021, Volume: 16, Issue:11

    Topics: Anilides; Animals; Benzeneacetamides; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Synergism; Everolimus; Female; Gene Expression Regulation, Neoplastic; Glucose; Glutaminase; Glutamine; Humans; Kidney Neoplasms; Mice; Pyridines; Signal Transduction; Thiadiazoles; Xenograft Model Antitumor Assays

2021
Targeting of the glutamine transporter SLC1A5 induces cellular senescence in clear cell renal cell carcinoma.
    Biochemical and biophysical research communications, 2022, 06-30, Volume: 611

    Topics: Amino Acid Transport System ASC; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Proliferation; Cellular Senescence; Gene Expression Regulation, Neoplastic; Glutamine; Humans; Kidney Neoplasms; Minor Histocompatibility Antigens; RNA, Small Interfering

2022
Nicotinamide-N-methyltransferase is a promising metabolic drug target for primary and metastatic clear cell renal cell carcinoma.
    Clinical and translational medicine, 2022, Volume: 12, Issue:6

    Topics: Carcinoma, Renal Cell; Deoxyglucose; Glucose; Glutamine; Humans; Kidney Neoplasms; Niacinamide; Tumor Microenvironment

2022
Efficacy and Safety of Telaglenastat Plus Cabozantinib vs Placebo Plus Cabozantinib in Patients With Advanced Renal Cell Carcinoma: The CANTATA Randomized Clinical Trial.
    JAMA oncology, 2022, 10-01, Volume: 8, Issue:10

    Topics: Angiogenesis Inhibitors; Carcinoma, Renal Cell; Double-Blind Method; Female; Glutamates; Glutaminase; Glutamine; Humans; Immune Checkpoint Inhibitors; Ipilimumab; Male; Middle Aged; Nivolumab; Protein Kinase Inhibitors

2022
Metabolic Adaptation as Potential Target in Papillary Renal Cell Carcinomas Based on Their In Situ Metabolic Characteristics.
    International journal of molecular sciences, 2022, Sep-13, Volume: 23, Issue:18

    Topics: Carcinoma, Renal Cell; Citrates; Glutamine; Humans; Kidney Neoplasms; Lactates; Malates; MTOR Inhibitors; Pyruvates; RNA, Messenger; Sirolimus; TOR Serine-Threonine Kinases

2022
Circ_0000069 contributes to the growth, metastasis and glutamine metabolism in renal cell carcinoma (RCC) via regulating miR-125a-5p-dependent SLC1A5 expression.
    Transplant immunology, 2023, Volume: 77

    Topics: Amino Acid Transport System ASC; Animals; Carcinoma, Renal Cell; Cell Proliferation; Glutamine; Humans; Kidney Neoplasms; Mice; MicroRNAs; Minor Histocompatibility Antigens

2023
In vivo characterization of glutamine metabolism identifies therapeutic targets in clear cell renal cell carcinoma.
    Science advances, 2022, 12-16, Volume: 8, Issue:50

    Topics: Animals; Carcinoma, Renal Cell; Glutaminase; Glutamine; Humans; Isocitrate Dehydrogenase; Kidney Neoplasms; Mice

2022
Targeting glutamine use in RCC.
    Nature reviews. Nephrology, 2023, Volume: 19, Issue:3

    Topics: Carcinoma, Renal Cell; Cell Proliferation; Glutamine; Humans; Kidney Neoplasms

2023
Renal enhanced CT images reveal the tandem mechanism between tumor cells and immunocytes based on bulk/single-cell RNA sequencing.
    Functional & integrative genomics, 2023, Mar-18, Volume: 23, Issue:2

    Topics: Carcinoma, Renal Cell; Glutamine; GTPase-Activating Proteins; Humans; Kidney Neoplasms; Sequence Analysis, RNA; Tomography, X-Ray Computed; Tumor Microenvironment

2023
Mitochondrial Uncoupling Inhibits Reductive Carboxylation in Cancer Cells.
    Molecular cancer research : MCR, 2023, 10-02, Volume: 21, Issue:10

    Topics: Carcinoma, Renal Cell; Glutamine; Humans; Kidney Neoplasms; NAD

2023
VHL-deficiency leads to reductive stress in renal cells.
    Free radical biology & medicine, 2023, 11-01, Volume: 208

    Topics: Carcinoma, Renal Cell; Glutamine; Humans; Kidney Neoplasms; Up-Regulation; Von Hippel-Lindau Tumor Suppressor Protein

2023
Cell-programmed nutrient partitioning in the tumour microenvironment.
    Nature, 2021, Volume: 593, Issue:7858

    Topics: Animals; Carcinoma, Renal Cell; Cell Line, Tumor; Female; Glucose; Glutamine; Humans; Lipid Metabolism; Male; Mechanistic Target of Rapamycin Complex 1; Mice; Myeloid Cells; Neoplasms; Nutrients; Tumor Microenvironment

2021
VHL regulates the sensitivity of clear cell renal cell carcinoma to SIRT4-mediated metabolic stress via HIF-1α/HO-1 pathway.
    Cell death & disease, 2021, 06-16, Volume: 12, Issue:7

    Topics: Apoptosis; Carcinoma, Renal Cell; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Glutamine; Heme Oxygenase-1; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Kidney Neoplasms; Mitochondrial Proteins; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Reactive Oxygen Species; Signal Transduction; Sirtuins; Von Hippel-Lindau Tumor Suppressor Protein

2021
Glutaminase and poly(ADP-ribose) polymerase inhibitors suppress pyrimidine synthesis and VHL-deficient renal cancers.
    The Journal of clinical investigation, 2017, May-01, Volume: 127, Issue:5

    Topics: Animals; Carcinoma, Renal Cell; Glutamates; Glutaminase; Glutamine; Humans; Kidney Neoplasms; Mice; Mice, Nude; Phthalazines; Piperazines; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Reactive Oxygen Species; S Phase Cell Cycle Checkpoints; Von Hippel-Lindau Tumor Suppressor Protein; Xenograft Model Antitumor Assays

2017
Glutamine Addiction in Kidney Cancer Suppresses Oxidative Stress and Can Be Exploited for Real-Time Imaging.
    Cancer research, 2017, 12-01, Volume: 77, Issue:23

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Antineoplastic Agents; Antioxidants; Apoptosis; Benzeneacetamides; Carcinoma, Renal Cell; Deoxyguanosine; Glutaminase; Glutamine; Humans; Kidney Neoplasms; Mice; NF-E2 Transcription Factor; Oxidative Stress; Reactive Oxygen Species; Thiadiazoles; Xenograft Model Antitumor Assays

2017
Tumor-associated Macrophage-derived Interleukin-23 Interlinks Kidney Cancer Glutamine Addiction with Immune Evasion.
    European urology, 2019, Volume: 75, Issue:5

    Topics: Animals; Antibodies; Carcinoma, Renal Cell; Cell Proliferation; Cells, Cultured; Gene Ontology; Glutamine; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immune Evasion; Immune Tolerance; Interleukin-23; Kidney Neoplasms; Lymphocyte Activation; Macrophages; Mice; Oncogene Addiction; Survival Rate; T-Lymphocytes, Regulatory; Tumor Escape

2019
HIF1α Suppresses Tumor Cell Proliferation through Inhibition of Aspartate Biosynthesis.
    Cell reports, 2019, 02-26, Volume: 26, Issue:9

    Topics: Adult; Aged; Aged, 80 and over; Aspartate Aminotransferase, Cytoplasmic; Aspartate Aminotransferase, Mitochondrial; Aspartic Acid; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Proliferation; Female; Glutamine; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Kidney Neoplasms; Male; Middle Aged; Mitochondrial Proteins; Neoplasms; Oxidation-Reduction; Tumor Suppressor Proteins; Von Hippel-Lindau Tumor Suppressor Protein

2019
In vivo HIF-mediated reductive carboxylation is regulated by citrate levels and sensitizes VHL-deficient cells to glutamine deprivation.
    Cell metabolism, 2013, Mar-05, Volume: 17, Issue:3

    Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Carbon Isotopes; Carboxylic Acids; Carcinoma, Renal Cell; Cell Line, Tumor; Citrates; Extracellular Fluid; Gas Chromatography-Mass Spectrometry; Glutamine; Humans; Magnetic Resonance Spectroscopy; Mice; Models, Biological; Oxidation-Reduction; Von Hippel-Lindau Tumor Suppressor Protein

2013
Pleiotropic effects of the trichloroethylene-associated P81S VHL mutation on metabolism, apoptosis, and ATM-mediated DNA damage response.
    Journal of the National Cancer Institute, 2013, Sep-18, Volume: 105, Issue:18

    Topics: Animals; Apoptosis; Arginine; Ataxia Telangiectasia Mutated Proteins; Carcinoma, Renal Cell; Cell Cycle Proteins; DNA Damage; DNA-Binding Proteins; Embryonic Stem Cells; Glutamine; Humans; Hypoxia-Inducible Factor 1; Immunohistochemistry; Kidney Neoplasms; Mice; Occupational Exposure; Point Mutation; Proline; Protein Array Analysis; Protein Serine-Threonine Kinases; Serine; Teratoma; Trichloroethylene; Tumor Suppressor Proteins; Ubiquitin-Protein Ligases; Von Hippel-Lindau Tumor Suppressor Protein

2013
MYC oncogene overexpression drives renal cell carcinoma in a mouse model through glutamine metabolism.
    Proceedings of the National Academy of Sciences of the United States of America, 2015, May-26, Volume: 112, Issue:21

    Topics: Animals; Carcinoma, Renal Cell; Cell Line, Tumor; Disease Models, Animal; Disease Progression; Enzyme Inhibitors; Genes, myc; Genes, ras; Glutaminase; Glutamine; Humans; Kidney Neoplasms; Lipid Metabolism; Mice; Mice, SCID; Mice, Transgenic; RNA, Messenger; RNA, Neoplasm; Spectrometry, Mass, Electrospray Ionization; Sulfides; Thiadiazoles; Up-Regulation

2015
Metabolic vulnerabilities of MYC-induced cancer.
    Oncotarget, 2016, 05-24, Volume: 7, Issue:21

    Topics: Animals; Carcinoma, Renal Cell; Genes, myc; Glutamine; Kidney Neoplasms; Mice; Oncogenes

2016
SnapShot: Renal Cell Carcinoma.
    Cancer cell, 2016, Apr-11, Volume: 29, Issue:4

    Topics: Carcinoma, Renal Cell; Energy Metabolism; Genes, Neoplasm; Glucose; Glutamine; Glycolysis; Humans; Kidney Neoplasms; Lipids; Neoplasm Proteins; Neoplastic Syndromes, Hereditary

2016
Mitochondrial Sirt3 supports cell proliferation by regulating glutamine-dependent oxidation in renal cell carcinoma.
    Biochemical and biophysical research communications, 2016, 06-03, Volume: 474, Issue:3

    Topics: Carcinoma, Renal Cell; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation, Neoplastic; Glutamine; Humans; Kidney Neoplasms; Mitochondria; Mitochondrial Proteins; Oxidation-Reduction; Sirtuin 3; Tumor Cells, Cultured

2016
A Late G1 Lipid Checkpoint That Is Dysregulated in Clear Cell Renal Carcinoma Cells.
    The Journal of biological chemistry, 2017, 01-20, Volume: 292, Issue:3

    Topics: Carcinoma, Renal Cell; Cell Membrane; Endoplasmic Reticulum Stress; G1 Phase Cell Cycle Checkpoints; Glutamine; Humans; Kidney Neoplasms; Lipid Metabolism; MCF-7 Cells; Neoplasm Proteins; PTEN Phosphohydrolase; TOR Serine-Threonine Kinases

2017
Reductive carboxylation supports growth in tumour cells with defective mitochondria.
    Nature, 2011, Nov-20, Volume: 481, Issue:7381

    Topics: Acetyl Coenzyme A; Animals; Carcinoma, Renal Cell; Cell Hypoxia; Cell Line, Tumor; Citric Acid; Electron Transport; Electron Transport Complex I; Electron Transport Complex III; Fumarate Hydratase; Glucose; Glutamine; Humans; Isocitrate Dehydrogenase; Kidney Neoplasms; Mice; Mitochondria; NADP; Neoplasms

2011
Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia.
    Nature, 2011, Nov-20, Volume: 481, Issue:7381

    Topics: Acetyl Coenzyme A; Aryl Hydrocarbon Receptor Nuclear Translocator; Basic Helix-Loop-Helix Transcription Factors; Carbon; Carcinoma, Renal Cell; CD8-Positive T-Lymphocytes; Cell Hypoxia; Cell Line, Tumor; Cells, Cultured; Citric Acid Cycle; Glutamine; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Isocitrate Dehydrogenase; Ketoglutaric Acids; Kidney Neoplasms; Lipogenesis; Oxidation-Reduction; Oxygen; Palmitic Acid; Von Hippel-Lindau Tumor Suppressor Protein

2011
Optimization of expression and purification of two biologically active chimeric fusion proteins that consist of human interleukin-13 and Pseudomonas exotoxin in Escherichia coli.
    Protein expression and purification, 2005, Volume: 39, Issue:2

    Topics: ADP Ribose Transferases; Amino Acid Substitution; Anti-Bacterial Agents; Arginine; Bacterial Toxins; Carcinoma, Renal Cell; Cell Line, Tumor; Chromatography, Gel; Cloning, Molecular; Escherichia coli; Exotoxins; Genetic Vectors; Glutamine; Humans; Inclusion Bodies; Interleukin-13; Isopropyl Thiogalactoside; Kanamycin; Muramidase; Plasmids; Promoter Regions, Genetic; Protein Renaturation; Pseudomonas aeruginosa Exotoxin A; Recombinant Fusion Proteins; Time Factors; Transformation, Genetic; Virulence Factors

2005