glutaminase and Neuralgia

Neuropathic pain increases the risk of cardiovascular diseases including hypertension with the characteristic of sympathetic overactivity. The enhanced tonically active glutamatergic input to the rostral ventrolateral medulla (RVLM) contributes to sympathetic overactivity and blood pressure (BP) in cardiovascular diseases. We hypothesize that neuropathic pain enhances tonically active glutamatergic inputs to the RVLM, which contributes to high level of BP and sympathetic outflow. Animal model with the trigeminal neuropathic pain was induced by the infraorbital nerve-chronic constriction injury (ION-CCI). A significant increase in BP and renal sympathetic nerve activity (RSNA) was found in rats with ION-CCI (BP,

Topics: Animals; Excitatory Amino Acid Antagonists; Glutamic Acid; Glutaminase; Hyperalgesia; Hypertension; Male; Medulla Oblongata; Neuralgia; Paraventricular Hypothalamic Nucleus; Periaqueductal Gray; Rats, Sprague-Dawley; Receptors, Glutamate; Sympathetic Nervous System; Vesicular Glutamate Transport Protein 2