glutaminase and Lymphoma

glutaminase has been researched along with Lymphoma* in 6 studies

Reviews

1 review(s) available for glutaminase and Lymphoma

ArticleYear
Immunosuppression by L-asparaginase and related enzymes.
    Transplantation, 1971, Volume: 12, Issue:5

    Topics: Animals; Arginine; Asparaginase; Glutaminase; Graft Rejection; Humans; Hypersensitivity, Delayed; Immunity, Cellular; Immunosuppressive Agents; In Vitro Techniques; L-Serine Dehydratase; Leukemia; Lymphocyte Activation; Lymphoid Tissue; Lymphoma; Mice; Rabbits; Transplantation, Homologous

1971

Other Studies

5 other study(ies) available for glutaminase and Lymphoma

ArticleYear
Targeting glutaminase to starve lymphoma cells.
    Haematologica, 2023, 06-01, Volume: 108, Issue:6

    Topics: Asparaginase; Glutaminase; Humans; Lymphocytes; Lymphoma

2023
Evaluation of LDH-A and glutaminase inhibition in vivo by hyperpolarized 13C-pyruvate magnetic resonance spectroscopy of tumors.
    Cancer research, 2013, Jul-15, Volume: 73, Issue:14

    Hyperpolarized (13)C magnetic resonance spectroscopy provides a unique opportunity to detect real-time metabolic fluxes as a means to measure metabolic treatment responses in vivo. Here, we show that pharmacologic inhibition of lactate dehydrogenase-A suppressed the conversion of hyperpolarized (13)C-pyruvate to lactate in murine xenografts of P493 human lymphoma. In contrast, a glutaminase inhibitor reduced conversion of (13)C-pyruvate to alanine without affecting conversion of pyruvate to lactate. These results illustrate the ability to monitor biomarkers for responses to antimetabolic therapy in real-time, paving the way for clinical development of imaging biomarkers to monitor metabolic pharmacodynamics.

    Topics: Animals; Antimetabolites, Antineoplastic; B-Lymphocytes; Carbon Isotopes; Cell Line, Tumor; Glutaminase; Humans; Isoenzymes; L-Lactate Dehydrogenase; Lactate Dehydrogenase 5; Lactic Acid; Lymphoma; Magnetic Resonance Spectroscopy; Male; Mice; Pyruvic Acid; Xenograft Model Antitumor Assays

2013
Crystalline L-asparaginase from escherichia coli B.
    Science (New York, N.Y.), 1969, Aug-01, Volume: 165, Issue:3892

    L-Asparaginase has been crystallized from a partially purified extract of Escherichia coli B. The crystalline enzyme is homogeneous, as judged by analytical polyacrylamidegel electrophoresis and sedimentation behavior. This enzyme preparation is active in preventing lymphoma in mice and also has low glutaminase activity.

    Topics: Animals; Asparaginase; Crystallization; Electrophoresis; Escherichia coli; Glutaminase; Lymphoma; Mice; Ultracentrifugation

1969
Two L-asparaginases from Escherichia coli B. Their separation, purification, and antitumor activity.
    Biochemistry, 1967, Volume: 6, Issue:3

    Topics: Amidohydrolases; Antineoplastic Agents; Asparagine; Chromatography; Escherichia coli; Glutaminase; Hydrogen-Ion Concentration; Lymphoma

1967
EFFECT OF ADMINISTRATION OF THE ENZYME GLUTAMINASE ON THE GROWTH OF CANCER CELLS.
    Cancer research, 1964, Volume: 24

    Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Glutaminase; Leukemia; Leukemia, Experimental; Lymphoma; Lymphoma, Non-Hodgkin; Mercaptopurine; Mice; Neoplasms; Neoplasms, Experimental; Pharmacology; Research; Sarcoma 180; Toxicology

1964