glutaminase has been researched along with Lymphoma* in 6 studies
1 review(s) available for glutaminase and Lymphoma
| Article | Year |
|---|---|
Immunosuppression by L-asparaginase and related enzymes.
Topics: Animals; Arginine; Asparaginase; Glutaminase; Graft Rejection; Humans; Hypersensitivity, Delayed; Immunity, Cellular; Immunosuppressive Agents; In Vitro Techniques; L-Serine Dehydratase; Leukemia; Lymphocyte Activation; Lymphoid Tissue; Lymphoma; Mice; Rabbits; Transplantation, Homologous | 1971 |
5 other study(ies) available for glutaminase and Lymphoma
| Article | Year |
|---|---|
Targeting glutaminase to starve lymphoma cells.
Topics: Asparaginase; Glutaminase; Humans; Lymphocytes; Lymphoma | 2023 |
Evaluation of LDH-A and glutaminase inhibition in vivo by hyperpolarized 13C-pyruvate magnetic resonance spectroscopy of tumors.
Hyperpolarized (13)C magnetic resonance spectroscopy provides a unique opportunity to detect real-time metabolic fluxes as a means to measure metabolic treatment responses in vivo. Here, we show that pharmacologic inhibition of lactate dehydrogenase-A suppressed the conversion of hyperpolarized (13)C-pyruvate to lactate in murine xenografts of P493 human lymphoma. In contrast, a glutaminase inhibitor reduced conversion of (13)C-pyruvate to alanine without affecting conversion of pyruvate to lactate. These results illustrate the ability to monitor biomarkers for responses to antimetabolic therapy in real-time, paving the way for clinical development of imaging biomarkers to monitor metabolic pharmacodynamics. Topics: Animals; Antimetabolites, Antineoplastic; B-Lymphocytes; Carbon Isotopes; Cell Line, Tumor; Glutaminase; Humans; Isoenzymes; L-Lactate Dehydrogenase; Lactate Dehydrogenase 5; Lactic Acid; Lymphoma; Magnetic Resonance Spectroscopy; Male; Mice; Pyruvic Acid; Xenograft Model Antitumor Assays | 2013 |
Crystalline L-asparaginase from escherichia coli B.
L-Asparaginase has been crystallized from a partially purified extract of Escherichia coli B. The crystalline enzyme is homogeneous, as judged by analytical polyacrylamidegel electrophoresis and sedimentation behavior. This enzyme preparation is active in preventing lymphoma in mice and also has low glutaminase activity. Topics: Animals; Asparaginase; Crystallization; Electrophoresis; Escherichia coli; Glutaminase; Lymphoma; Mice; Ultracentrifugation | 1969 |
Two L-asparaginases from Escherichia coli B. Their separation, purification, and antitumor activity.
Topics: Amidohydrolases; Antineoplastic Agents; Asparagine; Chromatography; Escherichia coli; Glutaminase; Hydrogen-Ion Concentration; Lymphoma | 1967 |
EFFECT OF ADMINISTRATION OF THE ENZYME GLUTAMINASE ON THE GROWTH OF CANCER CELLS.
Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Glutaminase; Leukemia; Leukemia, Experimental; Lymphoma; Lymphoma, Non-Hodgkin; Mercaptopurine; Mice; Neoplasms; Neoplasms, Experimental; Pharmacology; Research; Sarcoma 180; Toxicology | 1964 |