glutaminase has been researched along with Lymphoma--Non-Hodgkin* in 5 studies
1 review(s) available for glutaminase and Lymphoma--Non-Hodgkin
| Article | Year |
|---|---|
[Enzyme therapy of neoplasms].
Topics: Animals; Arginase; Asparaginase; Carcinoma 256, Walker; Carcinoma, Brown-Pearce; Carcinoma, Ehrlich Tumor; Carcinoma, Krebs 2; Chymotrypsin; Deoxyribonucleases; Enzyme Therapy; Glutaminase; Hyaluronoglucosaminidase; Leukemia, Experimental; Leukemia, Radiation-Induced; Lyases; Lymphoma, Non-Hodgkin; Mammary Neoplasms, Experimental; Mice; Neoplasms, Experimental; Pyridoxal Phosphate; Rats; Ribonucleases; Salts; Sarcoma, Avian; Sarcoma, Experimental; Trypsin; Vanadium | 1971 |
4 other study(ies) available for glutaminase and Lymphoma--Non-Hodgkin
| Article | Year |
|---|---|
Antilymphoma activity of a glutaminase-free L-asparaginase of microbial origin.
Topics: Animals; Asparaginase; Escherichia coli; Female; Glutaminase; Lymphoma, Non-Hodgkin; Mice; Neoplasms, Experimental; Vibrio | 1977 |
The properties and large-scale production of L-asparaginase from citrobacter.
An intracellular L-asparaginase with antitumour activity was purified from a strain of Citrobacter. The optimum conditions for enzyme production by fermentation on scales up to 2700 l were investigated. Highest enzyme yield was obtained in corn-steep liquor medium (9-2%, W/V) at 37 degrees C. Oxygen limitation was not necessary for high enzyme yield. A total recovery of 4-3% from nucleic-acid-free extract and a 180-fold increase in specific activity were obtained after purificaiton. The specific activity of the purified preparation was 45 i.u./mg protein. The enzyme hydrolysed D-asparagine and L-glutamine at 7 and 5%, respectively, of its activity toward L-asparagine, but L-glutaminase activity could be demonstrated only at substrate concentrations above 5 mM. The Km values for L-asparagine and D-asparagine were 2-6 X 10(-5) and 1-4 X 10(-4) respectively. The anti-lymphoma activity of the enzyme was demonstrated with Gardner lymphosarcoma and was found only slightly less potent that Crasnitin, the most active asparaginase so far tested in this system. Topics: Animals; Asparaginase; Asparagine; Citrobacter; Culture Media; Drug Evaluation, Preclinical; Enterobacteriaceae; Fermentation; Glutaminase; Glutamine; Hydrogen-Ion Concentration; Lymphoma, Non-Hodgkin; Mice; Molecular Weight; Neoplasms, Experimental; Oxygen; Stereoisomerism; Temperature; Zea mays | 1975 |
Studies on the mechanism of inhibition of tumor growth by the enzyme glutaminase.
Topics: Amidohydrolases; Animals; Azaguanine; Azaserine; Glutaminase; Glycine; Leukemia L1210; Ligases; Lymphoma, Non-Hodgkin; Mice; Neoplasms, Experimental; Purines | 1966 |
EFFECT OF ADMINISTRATION OF THE ENZYME GLUTAMINASE ON THE GROWTH OF CANCER CELLS.
Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Glutaminase; Leukemia; Leukemia, Experimental; Lymphoma; Lymphoma, Non-Hodgkin; Mercaptopurine; Mice; Neoplasms; Neoplasms, Experimental; Pharmacology; Research; Sarcoma 180; Toxicology | 1964 |