glutaminase and Diarrhea

glutaminase has been researched along with Diarrhea* in 2 studies

Other Studies

2 other study(ies) available for glutaminase and Diarrhea

Article	Year
Pathological features of glutaminase toxicity. British journal of experimental pathology, 1980, Volume: 61, Issue:2 In an investigation of the toxicity of the anti-tumour enzyme glutaminase Rhesus monkeys, marmosets, rabbits and mice were given various doses of chemically modified glutaminase parenterally. The enzyme induced diarrhoea and dysentery and at all but the lowest doses caused illness which was fatal within 10 days. Pathological lesions produced were hepatic lipidosis and glycogen accumulation, and, in the primates, acute necrotizing colitis. Topics: Animals; Callitrichinae; Chemical and Drug Induced Liver Injury; Colitis; Diarrhea; Female; Glutaminase; Haplorhini; Intestines; Lipidoses; Liver; Macaca mulatta; Male; Mice; Rabbits	1980
Azotomycin--toxicologic, biochemical and pharmacologic studies in mice. Biochemical pharmacology, 1974, Dec-15, Volume: 23, Issue:24 Topics: Animals; Antibiotics, Antineoplastic; Asparagine; Aspartate Aminotransferases; Aspartic Acid; Ataxia; Azo Compounds; Carbon Radioisotopes; Carboxy-Lyases; Carcinoma, Hepatocellular; Chemical and Drug Induced Liver Injury; Diarrhea; DNA; Formates; Glutamate Dehydrogenase; Glutamate-Ammonia Ligase; Glutamates; Glutaminase; Lethal Dose 50; Ligases; Liver Neoplasms; Malate Dehydrogenase; Mice; Mice, Inbred Strains; Protein Biosynthesis; Seizures; Spleen; Time Factors	1974

Article

Year

Pathological features of glutaminase toxicity.

British journal of experimental pathology, 1980, Volume: 61, Issue:2

In an investigation of the toxicity of the anti-tumour enzyme glutaminase Rhesus monkeys, marmosets, rabbits and mice were given various doses of chemically modified glutaminase parenterally. The enzyme induced diarrhoea and dysentery and at all but the lowest doses caused illness which was fatal within 10 days. Pathological lesions produced were hepatic lipidosis and glycogen accumulation, and, in the primates, acute necrotizing colitis.

Topics: Animals; Callitrichinae; Chemical and Drug Induced Liver Injury; Colitis; Diarrhea; Female; Glutaminase; Haplorhini; Intestines; Lipidoses; Liver; Macaca mulatta; Male; Mice; Rabbits

1980

Azotomycin--toxicologic, biochemical and pharmacologic studies in mice.

Biochemical pharmacology, 1974, Dec-15, Volume: 23, Issue:24

Topics: Animals; Antibiotics, Antineoplastic; Asparagine; Aspartate Aminotransferases; Aspartic Acid; Ataxia; Azo Compounds; Carbon Radioisotopes; Carboxy-Lyases; Carcinoma, Hepatocellular; Chemical and Drug Induced Liver Injury; Diarrhea; DNA; Formates; Glutamate Dehydrogenase; Glutamate-Ammonia Ligase; Glutamates; Glutaminase; Lethal Dose 50; Ligases; Liver Neoplasms; Malate Dehydrogenase; Mice; Mice, Inbred Strains; Protein Biosynthesis; Seizures; Spleen; Time Factors

1974