glutamic acid has been researched along with Substance Withdrawal Syndrome in 158 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (0.63) | 18.7374 |
| 1990's | 36 (22.78) | 18.2507 |
| 2000's | 45 (28.48) | 29.6817 |
| 2010's | 58 (36.71) | 24.3611 |
| 2020's | 18 (11.39) | 2.80 |
| Authors | Studies |
|---|---|
| Chai, JR; Chen, YQ; Deng, YZ; Du, JY; Fang, JF; Fang, JQ; Li, QL; Li, XP; Liu, JG; Liu, R; Liu, ZQ; Long, JD; Shao, XM; Sun, X; Wang, Q; Wang, YJ; Yao, SY; Zan, GY | 1 |
| Dahlgren, MK; Davis, KA; Fitzmaurice, GM; Gruber, S; Kuppe, MK; Lukas, SE; Zuo, CS | 1 |
| Davis, KA; Lukas, SE; Zuo, CS | 1 |
| Fu, R; Li, W; Matthew, L; Mei, Q; Wu, L; Wu, W; Ye, JH; Zhou, Z; Zuo, Q; Zuo, W | 1 |
| Cole, RD; Gould, TJ; Kutlu, MG; Matchanova, A; Parikh, V; Zimmerman, M | 1 |
| Bernat, N; Gatterer, A; Inbar, D; Inbar, K; Kupchik, YM; Levi, LA; Nachshon, N | 1 |
| Agostini, JF; Baldin, SL; Bernardo, HT; Costa, NLF; de Pieri Pickler, K; Manenti, MC; Mendes, NV; Rico, EP | 1 |
| McCool, BA; McGinnis, MM; Parrish, BC | 1 |
| Dong, Y; Li, Q; Lin, YQ; Song, K; Sun, YG; Yan, W; Zhang, XY | 1 |
| Alen, F; Arco, R; Ballesta, A; Decara, J; Gómez de Heras, R; Orio, L; Pavón, FJ; Ramírez-López, M; Rodríguez de Fonseca, F; Serrano, A; Suárez, J; Vadas, E; Vargas, A | 1 |
| Gao, Q; Guan, YZ; Li, XT; Li, XX; Liu, X; Liu, Y; Ma, W; Peng, Y; Wang, H; Wang, N; Xu, YM; Yang, T; Zhu, XF | 1 |
| Gupta, A; Kaur, A; Khan, H; Singh, TG | 1 |
| Diaz, MR; Gamble, ME; Przybysz, KR | 1 |
| Carcoba, LM; DeBiasi, M; Mendez, IA; O'Dell, LE; Ortegon, S; Uribe, KP | 1 |
| Engeli, EJE; Henning, A; Herdener, M; Hock, A; Hulka, LM; Seifritz, E; Steinegger, CA; Zoelch, N | 1 |
| Chu, C; Cui, D; Guo, X; Lai, B; Lei, C; Sheng, H; Yang, L; Yu, L; Yuan, Y; Zheng, P | 1 |
| Anton, RF; Book, S; Bristol, E; Brown, TR; Hoffman, M; Prisciandaro, JJ; Voronin, K | 1 |
| Gakare, SG; Patni, PP; Ugale, RR; Varghese, SS; Wagh, SA | 1 |
| Choi, SH; Hwang, SH; Kim, HC; Kim, HJ; Lee, BH; Lee, RM; Nah, SY; Park, SD; Rhim, H | 1 |
| Althobaiti, YS; Das, SC; Hammad, AM; Sari, Y | 1 |
| Goudriaan, AE; Kaag, AM; Kooi, DP; Schmaal, L; Schulte, M; van den Brink, W; Wiers, RW | 1 |
| Carcoba, LM; Flores, RJ; Natividad, LA; O'Dell, LE | 1 |
| Chang, S; Cho, HW; Choe, ES; Kim, HY; Kim, J; Lee, DK; Oh, JH; Ryu, IS; Seo, JW; Seo, SY; Shim, I; Yang, JH; Yoon, SS | 1 |
| Lindsay, JH; Prosser, RA | 1 |
| Shin, CB; Szumlinski, KK | 1 |
| Chappell, AM; McCool, BA; McGinnis, MM; Morales, M; Robinson, SL | 1 |
| Hamed, A; Kursa, MB | 1 |
| Degenhardt, F; Ende, G; Foo, JC; Frank, J; Frischknecht, U; Hall, ASM; Heilmann-Heimbach, S; Hermann, D; Kiefer, F; Mann, K; Nöthen, MM; Rietschel, M; Sack, M; Sommer, WH; Spanagel, R; Streit, F; Treutlein, J; Witt, SH | 1 |
| Barakat, A; Elbadr, MM; Hamdy, MM | 1 |
| Cui, C; Jia, M; Li, Y; Ma, H; Wang, N; Wang, X | 1 |
| Salimando, GJ; Silberman, Y; Snyder, AE; Winder, DG | 1 |
| Alén, F; Arco, R; Bajo, M; Ballesta, A; Khom, S; Kirson, D; Martin-Fardon, R; Natividad, LA; Patel, RR; Roberto, M; Rodríguez de Fonseca, F; Rubio, L; Suárez, J; Varodayan, FP | 1 |
| Arolt, V; Bauer, J; Bening, J; Heindel, W; Kugel, H; Ohrmann, P; Patschke, J; Pedersen, A; Scherbaum, N | 1 |
| Alajaji, M; Bowers, MS; Damaj, MI; Knackstedt, L | 1 |
| D'Souza, MS; Markou, A | 1 |
| Belcher, AM; Chefer, S; Schindler, CW; Stein, EA; Vaupel, DB; Yang, S; Yang, Y | 1 |
| Holmes, A; Krystal, JH; Spanagel, R | 1 |
| Gardner, PD; Liu, L; Pang, X; Tapper, AR; Zhao-Shea, R | 1 |
| Qi, Z; Tretter, F; Voit, EO | 1 |
| Becker, HC; Mulholland, PJ | 1 |
| Medrano, MC; Mendiguren, A; Pineda, J | 1 |
| Cao, D; Cao, M; Fu, G; Guo, M; Liang, J; Wu, Q; Zhu, S | 1 |
| DeBold, JF; Holly, EN; Hwa, LS; Miczek, KA; Nathanson, AJ; Newman, EL; Shimamoto, A; Tayeh, JK; Wilens, AR | 1 |
| Beaumont, M; Doyle, M; Heshmati, M; Khibnik, LA; Nestler, EJ; Russo, SJ; Slesinger, PA | 1 |
| Dao, M; Martemyanov, KA; Orlandi, C; Ostrovskaya, O; Smith, R; Sutton, LP; Wee, S; Xie, K | 1 |
| Cosgrove, KP; Fucito, LM; Hillmer, AT; Mason, GF; O'Malley, SS | 1 |
| Alshehri, FS; Althobaiti, YS; Das, SC; Sari, Y | 1 |
| Das, HK; Jung, ME; Metzger, DB | 1 |
| Barry, SM; Go, BS; McGinty, JF | 1 |
| Azizi, H; Hooshmand, B; Javan, M; Semnanian, S | 1 |
| Brown, CN; Campbell, RR; Cohen, M; Fultz, EK; Kippin, TE; Klugmann, M; Lominac, KD; Martin, D; Miller, BW; Phillips, TJ; Quadir, SG; Szumlinski, KK; Thompson, AB; von Jonquieres, G | 1 |
| Morgenstern, R; Netzhammer, N; Seidemann, T; Spies, C; Wernecke, KD | 1 |
| Demirakca, T; Dieter, S; Ende, G; Falfan-Melgoza, C; Frischknecht, U; Hermann, D; Kiefer, F; Krumm, B; Mann, KF; Sack, M; Sommer, WH; Spanagel, R; Tunc-Skarka, N; van Eijk, J; Wang, GY; Weber-Fahr, W | 1 |
| Gao, G; Heng, L; Jia, D; Qu, L; Song, J; Wang, X; Wang, Y; Zhang, H | 1 |
| Chang, L; Ernst, T | 1 |
| Luong, R; Mayer, D; Orduna, J; Pfefferbaum, A; Sullivan, EV; Vinco, S; Zahr, NM | 1 |
| Alvarez, FJ; Das, P; Gunning, WT; Lilly, SM; Tietz, EI; Zerda, R | 1 |
| Bachtell, RK; Self, DW | 1 |
| Hsu, KS; Huang, CC; Lee, CC; Liang, YC; Wu, MY | 1 |
| Biermann, T; Bleich, S; Frieling, H; Hillemacher, T; Kornhuber, J; Lenz, B; Muschler, M; Reulbach, U | 1 |
| Baucum, AJ; Colbran, RJ; Conrad, KL; Kash, TL; Winder, DG | 1 |
| Creton, C; Engblom, D; Halbout, B; Lüscher, C; Mameli, M; Parkitna, JR; Spanagel, R | 1 |
| Shen, G; Tietz, EI; Van Sickle, BJ | 1 |
| Patil, T; Raffa, RB; Rawls, SM; Yuvasheva, E | 1 |
| Becker, HC; Chandler, LJ; Mulholland, PJ; Woodward, JJ | 1 |
| Alvarez, VA; Bock, R; Christensen, CH; Dobi, A; Seabold, GK | 1 |
| Do, PH; Kalivas, PW; Moussawi, K; Reichel, CM; See, RE | 1 |
| Ende, G; Frischknecht, U; Heinrich, M; Hermann, D; Hoerst, M; Kiefer, F; Mann, K; Tunc-Skarka, N; Vollmert, C; Vollstädt-Klein, S | 1 |
| Carrillo, M; Melloni, RH; Ricci, LA | 1 |
| Anton, RF; Baros, AM; Latham, PK; Myrick, H; Randall, PK; Schacht, JP; Waid, LR; Wright, TM | 1 |
| Araki, H; Gomita, Y; Ishida, S; Jin, C; Kawasaki, H; Kawasaki, Y; Kitamura, Y; Sendo, T | 1 |
| Abdel-Rahman, MS; Abdel-Zaher, AO; Elwasei, FM | 1 |
| Devaud, LL; Macklin, ZL; Walls, SA | 1 |
| Ende, G; Frischknecht, U; Hansson, AC; Hermann, D; Hoerst, M; Kiefer, F; Krumm, B; Mann, K; Perreau-Lenz, S; Sartorius, A; Sommer, WH; Spanagel, R; Tunc-Skarka, N; Weber-Fahr, W | 1 |
| Brunt, TM; McMaster, MT; Niesink, RJ; van Amsterdam, JG | 1 |
| Bu, Q; Cen, X; Deng, P; Deng, Y; Hu, C; Hu, Z; Li, Y; Shao, X; Xu, Y; Yan, G; Zhao, J; Zhao, Y; Zhou, J; Zhu, R | 1 |
| Choi, DS; Frye, MA; Hinton, DJ; Jacobson, TL; Lee, MR; Macura, SI; Mishra, PK; Mrazek, DA | 1 |
| Chen, Z; Fan, YY; Fang, Q; He, P; Hu, WW; Ohtsu, H; Xu, TL; Xu, ZH; Yan, HJ; Yang, Y; Zhang, CY; Zhang, XN; Zhong, K | 1 |
| Buczynski, MW; Natividad, LA; O'Dell, LE; Parsons, LH; Torres, OV | 1 |
| Baker, DA; Kau, KS; Kong, L; Lutgen, V; Madayag, A; Mantsch, JR | 1 |
| Alexander, NJ; Christian, DT; Diaz, MR; McCool, BA | 1 |
| Gabriele, A; Pacchioni, AM; See, RE | 1 |
| Binkert, CA; Brügger, M; Froehlich, JM; Graf, N; Grosshans, M; Gutzeit, A; Herdener, M; Hergan, K; Kos, S; Meier, D; Mutschler, J; Reischauer, C; Schubert, T; Straka, M; Sutter, R | 1 |
| Abdel-Zaher, AO; Al-Shaibani, NK; Farghly, HM; Hamdy, MM; Mostafa, MG; Omran, GA | 1 |
| Clark, JD; Li, X | 1 |
| Hotsenpiller, G; Wolf, ME | 1 |
| Kalivas, PW; Lake, R; Ramamoorthy, S; Samuvel, DJ; Shen, H; Xi, ZX | 1 |
| Kendig, JJ; Li, HF | 1 |
| Baker, DA; Kalivas, PW; Lake, RW; McFarland, K; Shen, H; Tang, XC; Toda, S | 1 |
| Ansseau, M; De Witte, P; Pinto, E; Verbanck, P | 1 |
| Bao, GB; Bao, L; Fan, HP; Lu, YJ; Pei, G; Pu, L; Wu, CF; Xu, NJ; Zhang, X | 1 |
| Cao, JL; Gu, J; Yang, GD; Zeng, YM; Zhang, YH; Zhou, WH | 1 |
| Goldman, D; Heinz, A; Higley, JD; Krystal, JH; Schäfer, M | 1 |
| Kozell, LB; Meshul, CK | 1 |
| Belknap, JK; Buck, KJ; Crabbe, JC; Fehr, C; Kosobud, AE; Metten, P; Shirley, RL | 1 |
| Cao, JL; Gu, J; Liu, HF; Xie, XH; Yang, GD; Zhou, WH | 1 |
| Faleiro, LJ; Jones, S; Kauer, JA | 1 |
| De Witte, P | 1 |
| Celik, T; Ceyhan, M; Coşar, A; Demirtaş, S; Kayir, H; Uzbay, IT | 1 |
| Kendig, JJ; Peters, MC; Sweitzer, SM; Wong, SME | 1 |
| Littleton, J | 1 |
| Guo, M; Hao, Y; Wu, CF; Wu, MF; Yang, JY | 1 |
| Bajo, M; Crawford, E; Madamba, SG; Roberto, M; Siggins, GR | 1 |
| Barik, J; Wonnacott, S | 1 |
| Rebec, GV; Sun, W | 1 |
| Eşel, E | 1 |
| De Witte, P; Dravolina, O; Lallemand, F; Ward, RJ | 1 |
| Badawy, AA; Huebner, A; Krimphove, M; Morgenstern, R; Saellstroem Baum, S; Spies, CD | 1 |
| Ben-Shahar, O; Brake, W; Cook, M; Ettenberg, A; Heston, R; Joyce, M; Keeley, P; Nyffeler, M | 1 |
| Biswas, S; Harlan, RE; Neisewander, JL; Zavala, AR | 1 |
| Boutros, N; Stanley, J; Sundaresan, K; Ziemann, U | 1 |
| Markou, A; Paterson, NE | 1 |
| Greenfield, LJ; Shen, G; Song, J; Tietz, EI | 1 |
| Feltenstein, MW; See, RE | 1 |
| Fry, JP; Herz, A; Zieglgänsberger, W | 1 |
| Carboni, S; Rossetti, ZL | 1 |
| Feng, YZ; Ho, IK; Rockhold, RW; Zhang, T | 1 |
| Shibata, S; Shindou, T; Tominaga, K; Watanabe, S | 1 |
| Aghajanian, GK; Kogan, JH; Moghaddam, B | 1 |
| Bhargava, HN; Gudehithlu, KP; Reddy, PL | 1 |
| Feng, Y; Ho, IK; Rockhold, RW; Zhang, T | 1 |
| Aghajanian, GK; Kogan, JH | 1 |
| Ho, IK; Tokuyama, S; Wakabayashi, H | 1 |
| Ibuki, T; Jhamandas, KH; Marsala, M; Yaksh, TL | 1 |
| Ho, IK; Tokuyama, S | 1 |
| Cox, BM; Noble, F | 1 |
| Browning, MD; Hoffman, PL; Lickteig, RL; Nunley, KR; Snell, LD; Tabakoff, B | 1 |
| Ho, IK; Hoshi, K; Ma, T | 1 |
| Feng, YZ; Ho, IK; Hoshi, K; Rockhold, RW; Tokuyama, S | 1 |
| Ho, IK; Rockhold, RW; Zhu, H | 1 |
| Kosten, TR | 1 |
| Dunworth, SJ; Stephens, DN | 1 |
| Feng, YZ; Ho, IK; Tokuyama, S; Wakabayashi, H; Zhu, H | 1 |
| Contreras, E; Hernandez, L; Rada, P; Sepulveda, MJ; Tucci, S | 1 |
| Bertault, T; Caraty, A; Delaleu, B; Huyghe, B; Malpaux, B; Picard, S; Skinner, DC; Thiéry, JC | 1 |
| Elsworth, JD; Punch, LJ; Taylor, JR | 1 |
| Bockaert, J; Manzoni, O; Pujalte, D; Williams, J | 1 |
| Hanin, I; Kindel, G; Wülfert, E; Zhang, X | 1 |
| Emre, N; Keys, AS; Mark, GP; Meshul, CK | 1 |
| Ho, IK; Jang, CG; Oh, S; Zhu, H | 1 |
| Buckman, JF; Finn, DA; Janowsky, A; Meshul, CK | 1 |
| Dahchour, A; De Witte, P | 3 |
| Manzoni, OJ; Williams, JT | 1 |
| Carboni, S; Fadda, F; Rossetti, ZL | 1 |
| Ho, IK; Jang, C; Park, Y; Rockhold, RW | 1 |
| Forray, MI; Fuentealba, JA; Gysling, K | 1 |
| Chen, JC; Chiang, YC; Huang, YK; Liang, CS; Liang, KW | 1 |
| Takahashi, M; Tokuyama, S; Yamamoto, T | 1 |
| Ho, IK; Oh, S; Tokuyama, S; Yamamoto, T; Zhu, H | 1 |
| Minami, M; Nakagawa, T; Ozawa, T; Satoh, M; Shige, K | 1 |
| Angulo, JA; Loonam, TM; Noailles, PA; Zhang, Y | 1 |
| Favalli, L; Frattini, P; Govoni, S; Masoero, E; Pascale, A; Rozza, A; Scelsi, R | 1 |
| Ariciŏglu, F; Dizdar, Y; Esin, Y; Koyuncuŏglu, H; Uresin, Y | 1 |
| Karanian, J; Linnoila, M; Morgan, PF; Nadi, NS | 1 |
| Little, HJ | 1 |
| Akaoka, H; Aston-Jones, G | 1 |
19 review(s) available for glutamic acid and Substance Withdrawal Syndrome
| Article | Year |
|---|---|
Novel Targets Explored in the Treatment of Alcohol Withdrawal Syndrome.
Topics: Alcoholism; Animals; Brain; Ethanol; Glutamic Acid; Humans; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome | 2021 |
Kinase interest you in treating incubated cocaine-craving? A hypothetical model for treatment intervention during protracted withdrawal from cocaine.
Topics: Animals; Behavior, Addictive; Cocaine; Cocaine-Related Disorders; Craving; Cues; Drug-Seeking Behavior; Excitatory Amino Acid Agents; Extinction, Psychological; Glutamic Acid; Humans; MAP Kinase Signaling System; Mice; Prefrontal Cortex; Protein Kinase C; Rats; Substance Withdrawal Syndrome; Withholding Treatment | 2018 |
The "stop" and "go" of nicotine dependence: role of GABA and glutamate.
Topics: Animals; Behavior, Animal; Brain; Conditioning, Psychological; Dopamine; Excitatory Amino Acid Antagonists; GABA Agonists; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Limbic System; Nicotine; Nicotinic Antagonists; Receptors, Glutamate; Reinforcement, Psychology; Smoking Cessation; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2013 |
Glutamatergic targets for new alcohol medications.
Topics: Alcoholism; Animals; Drug-Seeking Behavior; Glutamic Acid; Humans; Molecular Targeted Therapy; Protein Subunits; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome | 2013 |
Neurochemical mechanisms of alcohol withdrawal.
Topics: Alcoholism; Animals; Biogenic Amines; Brain; Brain Chemistry; Glutamic Acid; Humans; Neurotransmitter Agents; Substance Withdrawal Syndrome | 2014 |
How Imaging Glutamate, γ-Aminobutyric Acid, and Dopamine Can Inform the Clinical Treatment of Alcohol Dependence and Withdrawal.
Topics: Alcoholism; Cross-Sectional Studies; Dopamine; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Neuroimaging; Substance Withdrawal Syndrome; Treatment Outcome | 2015 |
Possible long-term effects of γ-hydroxybutyric acid (GHB) due to neurotoxicity and overdose.
Topics: Alcoholism; Anesthetics; Anesthetics, Dissociative; Animals; Central Nervous System Depressants; Cognition Disorders; Coma; Drug Overdose; Ethanol; Glutamic Acid; Humans; Illicit Drugs; Ketamine; Neurotoxicity Syndromes; Oxidative Stress; Sodium Oxybate; Substance Withdrawal Syndrome; Substance-Related Disorders; Succinate-Semialdehyde Dehydrogenase | 2012 |
Alcohol and withdrawal: from animal research to clinical issues.
Topics: Alcohol-Induced Disorders, Nervous System; Animals; Disease Models, Animal; Ethanol; Glutamic Acid; Humans; Receptors, N-Methyl-D-Aspartate; Stress, Physiological; Stress, Psychological; Substance Withdrawal Syndrome | 2003 |
Neurobiological correlates of the disposition and maintenance of alcoholism.
Topics: Acute Disease; Alcoholism; Brain; Chronic Disease; Dopamine; Drug Tolerance; Ethanol; gamma-Aminobutyric Acid; Genetic Predisposition to Disease; Glutamic Acid; Recurrence; Reward; Risk Factors; Serotonin; Substance Withdrawal Syndrome; Synaptic Transmission | 2003 |
Neurochemical mechanisms underlying alcohol withdrawal.
Topics: Alcoholism; Animals; Calcium Channels; Ethanol; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Substance Withdrawal Syndrome | 1998 |
[Neurobiology of alcohol withdrawal inhibitory and excitatory neurotransmitters].
Topics: Brain; Calcium; Ethanol; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Neurotransmitter Agents; Substance Withdrawal Syndrome | 2006 |
Animal models and treatments for addiction and depression co-morbidity.
Topics: Adrenergic Uptake Inhibitors; Animals; Antipsychotic Agents; Central Nervous System Stimulants; Clozapine; Depressive Disorder; Dopamine Agents; Glutamic Acid; Humans; Norepinephrine; Selective Serotonin Reuptake Inhibitors; Substance Withdrawal Syndrome; Substance-Related Disorders | 2007 |
The neurocircuitry of addiction: an overview.
Topics: Animals; Behavior, Addictive; Behavior, Animal; Central Nervous System Agents; Dopamine; Glutamic Acid; Humans; Limbic System; Models, Animal; Models, Psychological; Neural Pathways; Neurotransmitter Agents; Recurrence; Substance Withdrawal Syndrome; Substance-Related Disorders | 2008 |
Glutamate in opioid dependence.
Topics: Analgesics, Opioid; Animals; Butorphanol; Glutamic Acid; Locus Coeruleus; Microdialysis; Opioid-Related Disorders; Rats; Receptors, Opioid, kappa; Substance Withdrawal Syndrome | 1997 |
The role of glutamate in physical dependence on opioids.
Topics: Analgesics, Opioid; Animals; Butorphanol; Disease Models, Animal; Glutamic Acid; Locus Coeruleus; Neurons, Afferent; Opioid-Related Disorders; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa; Substance Withdrawal Syndrome | 1998 |
Pharmacotherapy of cerebral ischemia in cocaine dependence.
Topics: Aspirin; Brain; Brain Ischemia; Cerebrovascular Circulation; Cocaine; Cocaine-Related Disorders; Cognition Disorders; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Humans; Intracranial Embolism and Thrombosis; Male; Nerve Degeneration; Neuropsychological Tests; Platelet Aggregation Inhibitors; Radionuclide Imaging; Substance Withdrawal Syndrome | 1998 |
[On the role of glutamate within the locus coeruleus during the development of opioid dependence and on the expression of withdrawal from dependence on opioids].
Topics: Animals; Glutamic Acid; Humans; Locus Coeruleus; Opioid-Related Disorders; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome | 2000 |
Comparison of cocaine- and methamphetamine-evoked dopamine and glutamate overflow in somatodendritic and terminal field regions of the rat brain during acute, chronic, and early withdrawal conditions.
Topics: Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Glutamic Acid; Male; Methamphetamine; Motor Activity; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Substantia Nigra | 2001 |
Mechanisms that may underlie the behavioural effects of ethanol.
Topics: Alcoholic Intoxication; Animals; Aspartic Acid; Behavior; Behavior, Animal; Calcium; Calcium Channels; Cell Membrane; Dihydropyridines; Drug Tolerance; Ethanol; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Humans; Ion Channel Gating; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome; Synaptic Transmission | 1991 |
4 trial(s) available for glutamic acid and Substance Withdrawal Syndrome
| Article | Year |
|---|---|
Effects of Gabapentin on Dorsal Anterior Cingulate Cortex GABA and Glutamate Levels and Their Associations With Abstinence in Alcohol Use Disorder: A Randomized Clinical Trial.
Topics: Adult; Alcoholism; Double-Blind Method; Female; Gabapentin; gamma-Aminobutyric Acid; Glutamic Acid; Gyrus Cinguli; Humans; Male; Middle Aged; Proton Magnetic Resonance Spectroscopy; Substance Withdrawal Syndrome | 2021 |
The effect of N-acetylcysteine on brain glutamate and gamma-aminobutyric acid concentrations and on smoking cessation: A randomized, double-blind, placebo-controlled trial.
Topics: Acetylcysteine; Adult; Craving; Double-Blind Method; gamma-Aminobutyric Acid; Glutamic Acid; Gyrus Cinguli; Humans; Male; Smoking Cessation; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2017 |
Neurocognitive performance, alcohol withdrawal, and effects of a combination of flumazenil and gabapentin in alcohol dependence.
Topics: Adult; Alcohol Drinking; Alcoholism; Amines; Cognition; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Female; Flumazenil; Gabapentin; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Male; Middle Aged; Recurrence; Substance Withdrawal Syndrome; Treatment Outcome | 2011 |
Insula-specific H magnetic resonance spectroscopy reactions in heavy smokers under acute nicotine withdrawal and after oral nicotine substitution.
Topics: Administration, Oral; Adult; Behavior, Addictive; Carbon Monoxide; Case-Control Studies; Cerebral Cortex; Functional Neuroimaging; Glutamic Acid; Glutamine; Humans; Inositol; Male; Middle Aged; Nicotine; Smoking; Substance Withdrawal Syndrome; Tobacco Use Cessation Devices | 2013 |
135 other study(ies) available for glutamic acid and Substance Withdrawal Syndrome
| Article | Year |
|---|---|
Amygdalar κ-opioid receptor-dependent upregulating glutamate transporter 1 mediates depressive-like behaviors of opioid abstinence.
Topics: Amygdala; Animals; Behavior, Animal; Depression; Disease Models, Animal; Dynorphins; Excitatory Postsynaptic Potentials; Glucose Transporter Type 1; Glutamic Acid; Male; Mice, Inbred C57BL; Mice, Knockout; Morphine; Neural Pathways; Nucleus Accumbens; p38 Mitogen-Activated Protein Kinases; Receptors, Opioid, kappa; Signal Transduction; Substance Withdrawal Syndrome | 2021 |
Elevated striatal glutamate + glutamine in recreational cannabis users during abstinence.
Topics: Cannabis; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Hallucinogens; Humans; Substance Withdrawal Syndrome | 2022 |
Lower dACC glutamate in cannabis users during early phase abstinence.
Topics: Cannabinoid Receptor Agonists; Cannabis; Dronabinol; gamma-Aminobutyric Acid; Glutamic Acid; Gyrus Cinguli; Hallucinogens; Humans; Protons; Sleep Initiation and Maintenance Disorders; Substance Withdrawal Syndrome | 2022 |
Adaptation in 5-HT
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Central Nervous System Depressants; Enzyme Inhibitors; Ethanol; Excitatory Postsynaptic Potentials; Glutamic Acid; Habenula; Neurons; Nociception; Rats; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin, 5-HT2; RNA, Messenger; Serotonin 5-HT2 Receptor Antagonists; Substance Withdrawal Syndrome | 2019 |
Cognitive rigidity and BDNF-mediated frontostriatal glutamate neuroadaptations during spontaneous nicotine withdrawal.
Topics: Adaptation, Physiological; Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Cognition; Conditioning, Operant; Corpus Striatum; Discrimination, Psychological; Frontal Lobe; Glutamic Acid; Male; Mice, Inbred C57BL; Nicotine; Nicotinic Agonists; Substance Withdrawal Syndrome; Synaptic Transmission | 2020 |
Projection-Specific Potentiation of Ventral Pallidal Glutamatergic Outputs after Abstinence from Cocaine.
Topics: Animals; Basal Forebrain; Cocaine-Related Disorders; Female; Glutamic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neural Pathways; Neuronal Plasticity; Neurons; Recurrence; Reward; Substance Withdrawal Syndrome | 2020 |
Ceftriaxone Attenuated Anxiety-Like Behavior and Enhanced Brain Glutamate Transport in Zebrafish Subjected to Alcohol Withdrawal.
Topics: Alcohol Drinking; Animals; Anxiety; Brain; Ceftriaxone; Ethanol; Glutamic Acid; Oxidative Stress; Substance Withdrawal Syndrome; Zebrafish | 2020 |
Withdrawal from chronic ethanol exposure increases postsynaptic glutamate function of insular cortex projections to the rat basolateral amygdala.
Topics: Administration, Inhalation; Alcoholism; Animals; Basolateral Nuclear Complex; Central Nervous System Depressants; Cerebral Cortex; Electric Stimulation; Electrophysiological Phenomena; Ethanol; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Ketamine; Male; Neural Pathways; Optogenetics; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome | 2020 |
Mu-Opioid Receptors Expressed in Glutamatergic Neurons are Essential for Morphine Withdrawal.
Topics: Analgesics, Opioid; Animals; Glutamic Acid; Male; Mice; Mice, Knockout; Morphine; Naloxone; Narcotic Antagonists; Neurons; Receptors, Opioid, mu; Substance Withdrawal Syndrome; Vesicular Glutamate Transport Protein 2 | 2020 |
Abrupt cessation of reboxetine along alcohol deprivation results in alcohol intake escalation after reinstatement of drinking.
Topics: Alcoholism; Animals; Drug-Seeking Behavior; Endocannabinoids; Glutamic Acid; Hippocampus; Male; Prefrontal Cortex; Rats; Rats, Wistar; Reboxetine; Self Administration; Signal Transduction; Substance Withdrawal Syndrome | 2021 |
7,8-Dihydroxyflavone Alleviates Anxiety-Like Behavior Induced by Chronic Alcohol Exposure in Mice Involving Tropomyosin-Related Kinase B in the Amygdala.
Topics: Amygdala; Animals; Anxiety; Behavior, Animal; Carbazoles; Disease Models, Animal; Ethanol; Excitatory Postsynaptic Potentials; Flavones; gamma-Aminobutyric Acid; Glutamic Acid; Indole Alkaloids; Inhibitory Postsynaptic Potentials; Male; Mice, Inbred C57BL; Pyramidal Cells; Receptor, trkB; Substance Withdrawal Syndrome; Synaptic Transmission | 2021 |
Moderate adolescent chronic intermittent ethanol exposure sex-dependently disrupts synaptic transmission and kappa opioid receptor function in the basolateral amygdala of adult rats.
Topics: Animals; Basolateral Nuclear Complex; Ethanol; Excitatory Postsynaptic Potentials; Female; Glutamic Acid; Male; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Sex Factors; Substance Withdrawal Syndrome; Synaptic Transmission | 2021 |
Amino acid systems in the interpeduncular nucleus are altered in a sex-dependent manner during nicotine withdrawal.
Topics: Amino Acids; Female; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Interpeduncular Nucleus; Male; Nicotine; Receptors, Corticotropin-Releasing Hormone; Serotonin; Substance Withdrawal Syndrome | 2022 |
Neurometabolic alterations in the nucleus accumbens of smokers assessed with
Topics: Adult; Glutamates; Glutamic Acid; Glutamine; Glycine; Humans; Inflammation Mediators; Inositol; Magnetic Resonance Spectroscopy; Male; Nucleus Accumbens; Patient Acuity; Smokers; Substance Withdrawal Syndrome; Tobacco Smoking; Tobacco Use Disorder | 2021 |
Activity in projection neurons from prelimbic cortex to the PVT is necessary for retrieval of morphine withdrawal memory.
Topics: Animals; Conditioning, Classical; Cytoskeletal Proteins; Glutamic Acid; Male; Memory; Mental Recall; Mice, Inbred C57BL; Midline Thalamic Nuclei; Morphine; Nerve Tissue Proteins; Neurons; Prefrontal Cortex; Substance Withdrawal Syndrome | 2021 |
Prevention of glutamate excitotoxicity in lateral habenula alleviates ethanol withdrawal-induced somatic and behavioral effects in ethanol dependent mice.
Topics: Alcoholism; Amino Acid Transport System X-AG; Animals; Anxiety; Ethanol; Glutamic Acid; Habenula; Male; Mice; Phenols; Piperidines; Substance Withdrawal Syndrome | 2022 |
Gintonin attenuates depressive-like behaviors associated with alcohol withdrawal in mice.
Topics: Acetylcholine; Animals; Calcium; Catecholamines; Disease Models, Animal; Glutamic Acid; Male; Mice; Mice, Inbred C57BL; Panax; Phytotherapy; Plant Extracts; Receptors, Lysophosphatidic Acid; Substance Withdrawal Syndrome | 2017 |
Effects of repeated cocaine exposure and withdrawal on voluntary ethanol drinking, and the expression of glial glutamate transporters in mesocorticolimbic system of P rats.
Topics: Alcohol Drinking; Amino Acid Transport System X-AG; Animals; Cocaine; Ethanol; Glutamic Acid; Male; Neuroglia; Nucleus Accumbens; Prefrontal Cortex; Rats; Substance Withdrawal Syndrome | 2017 |
Amino acid modulation of dopamine in the nucleus accumbens mediates sex differences in nicotine withdrawal.
Topics: Amino Acids; Animals; Disease Models, Animal; Dopamine; Female; Glutamic Acid; Male; Mecamylamine; Nicotine; Nicotinic Antagonists; Nucleus Accumbens; Rats; Rats, Wistar; Sex Factors; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2018 |
Behavioral changes after nicotine challenge are associated with α7 nicotinic acetylcholine receptor-stimulated glutamate release in the rat dorsal striatum.
Topics: Action Potentials; alpha7 Nicotinic Acetylcholine Receptor; Animals; Behavior, Animal; Corpus Striatum; Glutamic Acid; Male; Motor Activity; Nicotine; Nicotinic Agonists; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 2017 |
The Mammalian Circadian Clock Exhibits Chronic Ethanol Tolerance and Withdrawal-Induced Glutamate Hypersensitivity, Accompanied by Changes in Glutamate and TrkB Receptor Proteins.
Topics: Animals; Brain-Derived Neurotrophic Factor; Central Nervous System Depressants; Circadian Clocks; Drug Tolerance; Ethanol; Glutamic Acid; Male; Membrane Glycoproteins; Mice, Inbred C57BL; Phosphorylation; Protein-Tyrosine Kinases; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome; Suprachiasmatic Nucleus | 2018 |
Chronic Intermittent Ethanol Exposure Modulation of Glutamatergic Neurotransmission in Rat Lateral/Basolateral Amygdala is Duration-, Input-, and Sex-Dependent.
Topics: Administration, Inhalation; Animals; Anxiety; Basolateral Nuclear Complex; Central Nervous System Depressants; Estrous Cycle; Ethanol; Excitatory Postsynaptic Potentials; External Capsule; Female; Glutamic Acid; Internal Capsule; Male; Maze Learning; Rats, Sprague-Dawley; Sex Characteristics; Substance Withdrawal Syndrome; Synapses; Time Factors; Tissue Culture Techniques | 2018 |
Inter-individual differences in serotonin and glutamate co-transmission reflect differentiation in context-induced conditioned 50-kHz USVs response after morphine withdrawal.
Topics: Animals; Behavior, Animal; Brain; Conditioning, Psychological; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamic Acid; Male; Morphine; Opioid-Related Disorders; Rats, Sprague-Dawley; Reward; Serotonin; Substance Withdrawal Syndrome; Synaptic Transmission; Time Factors; Ultrasonic Waves; Vocalization, Animal | 2018 |
Glutamate concentration in the anterior cingulate cortex in alcohol dependence: association with alcohol withdrawal and exploration of contribution from glutamatergic candidate genes.
Topics: Adult; Aged; Alcoholism; Case-Control Studies; Creatine; Female; GATA4 Transcription Factor; Genetic Association Studies; Glutamic Acid; Gyrus Cinguli; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Substance Withdrawal Syndrome | 2018 |
Bupropion attenuates morphine tolerance and dependence: Possible role of glutamate, norepinephrine, inflammation, and oxidative stress.
Topics: Animals; Brain; Bupropion; Dose-Response Relationship, Drug; Drug Tolerance; Glutamic Acid; Glutathione; Inflammation; Male; Malondialdehyde; Mice; Morphine; Morphine Dependence; Naloxone; Nitric Oxide; Norepinephrine; Organophosphorus Compounds; Oxidative Stress; Pain Measurement; Substance Withdrawal Syndrome | 2018 |
Wnt7a in Mouse Insular Cortex Contributes to Anxiety-like Behavior During Protracted Abstinence from Morphine.
Topics: Animals; Anxiety; Behavior, Animal; Cerebral Cortex; Glutamic Acid; Male; Mice, Inbred C57BL; Morphine; Morphine Dependence; Narcotics; Neurons; Substance Withdrawal Syndrome; Wnt Proteins | 2018 |
Chronic Intermittent Ethanol and Acute Stress Similarly Modulate BNST CRF Neuron Activity via Noradrenergic Signaling.
Topics: Adrenergic Neurons; Animals; Corticotropin-Releasing Hormone; Ethanol; Excitatory Amino Acid Antagonists; Gene Knock-In Techniques; Glutamic Acid; Kynurenic Acid; Male; Membrane Potentials; Mice; Norepinephrine; Picrotoxin; Propranolol; Restraint, Physical; Septal Nuclei; Substance Withdrawal Syndrome | 2019 |
Cessation of fluoxetine treatment increases alcohol seeking during relapse and dysregulates endocannabinoid and glutamatergic signaling in the central amygdala.
Topics: Alcoholism; Animals; Central Amygdaloid Nucleus; Disease Models, Animal; Drug-Seeking Behavior; Endocannabinoids; Fluoxetine; Glutamic Acid; Male; Rats; Rats, Wistar; Recurrence; Selective Serotonin Reuptake Inhibitors; Signal Transduction; Substance Withdrawal Syndrome | 2020 |
Craving in alcohol-dependent patients after detoxification is related to glutamatergic dysfunction in the nucleus accumbens and the anterior cingulate cortex.
Topics: Adult; Alcoholism; Behavior, Addictive; Female; Glutamic Acid; Gyrus Cinguli; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Nucleus Accumbens; Substance Withdrawal Syndrome; Surveys and Questionnaires | 2013 |
Effects of the beta-lactam antibiotic ceftriaxone on nicotine withdrawal and nicotine-induced reinstatement of preference in mice.
Topics: Amino Acid Transport Systems; Animals; Anti-Bacterial Agents; Ceftriaxone; Conditioning, Psychological; Cysteine; Excitatory Amino Acid Transporter 2; Extinction, Psychological; Glutamic Acid; Male; Mice; Mice, Inbred ICR; Nicotine; Reinforcement, Psychology; Reward; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2013 |
Withdrawal from long-term methamphetamine self-administration 'normalizes' neurometabolites in rhesus monkeys: a (1) H MR spectroscopy study.
Topics: Animals; Brain; Caudate Nucleus; Central Nervous System Stimulants; Glutamic Acid; Glutamine; Gyrus Cinguli; Inositol; Longitudinal Studies; Macaca mulatta; Methamphetamine; Proton Magnetic Resonance Spectroscopy; Putamen; Self Administration; Substance Withdrawal Syndrome | 2015 |
Activation of GABAergic neurons in the interpeduncular nucleus triggers physical nicotine withdrawal symptoms.
Topics: Animals; GABAergic Neurons; Glutamic Acid; Light; Male; Mecamylamine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Tissue Proteins; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Phototherapy; Receptors, N-Methyl-D-Aspartate; Receptors, Nicotinic; Rhodopsin; Somatostatin; Substance Withdrawal Syndrome; Synaptic Transmission | 2013 |
A heuristic model of alcohol dependence.
Topics: Alcoholism; Diazepam; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Models, Biological; Models, Psychological; Neurotransmitter Agents; Substance Withdrawal Syndrome | 2014 |
Effect of ceftriaxone and topiramate treatments on naltrexone-precipitated morphine withdrawal and glutamate receptor desensitization in the rat locus coeruleus.
Topics: Analgesics, Opioid; Animals; Ceftriaxone; Fructose; Glutamic Acid; Locus Coeruleus; Male; Morphine Dependence; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Substance Withdrawal Syndrome; Topiramate | 2015 |
Chronic exposure to morphine decreases the expression of EAAT3 via opioid receptors in hippocampal neurons.
Topics: Animals; Blotting, Western; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Excitatory Amino Acid Transporter 3; Extracellular Space; Fluorescent Antibody Technique; Glutamic Acid; Hippocampus; Morphine; Narcotic Antagonists; Narcotics; Neurons; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Receptors, Opioid; RNA, Messenger; Substance Withdrawal Syndrome | 2015 |
Aggression and increased glutamate in the mPFC during withdrawal from intermittent alcohol in outbred mice.
Topics: Aggression; Animals; Behavior, Animal; Ethanol; Excitatory Amino Acid Antagonists; Glutamic Acid; Ketamine; Male; Memantine; Mice; Prefrontal Cortex; Receptors, N-Methyl-D-Aspartate; Social Behavior; Substance Withdrawal Syndrome | 2015 |
Stress and Cocaine Trigger Divergent and Cell Type-Specific Regulation of Synaptic Transmission at Single Spines in Nucleus Accumbens.
Topics: Animals; Cocaine; Dendritic Spines; Dominance-Subordination; Dopamine Uptake Inhibitors; Excitatory Postsynaptic Potentials; Glutamic Acid; Green Fluorescent Proteins; Mice, Inbred C57BL; Mice, Transgenic; Microscopy, Confocal; Nucleus Accumbens; Patch-Clamp Techniques; Receptors, Dopamine D1; Receptors, Dopamine D2; Stress, Psychological; Substance Withdrawal Syndrome; Synaptic Transmission; Tissue Culture Techniques | 2016 |
Regulator of G-Protein Signaling 7 Regulates Reward Behavior by Controlling Opioid Signaling in the Striatum.
Topics: Animals; Conditioning, Psychological; Corpus Striatum; Dopaminergic Neurons; Drug Tolerance; Female; Glutamic Acid; Male; Mice; Mice, Knockout; Morphine; Neurons; Nucleus Accumbens; Pain Measurement; Reward; RGS Proteins; Self Administration; Signal Transduction; Substance Withdrawal Syndrome | 2016 |
Binge ethanol withdrawal: Effects on post-withdrawal ethanol intake, glutamate-glutamine cycle and monoamine tissue content in P rat model.
Topics: Alcohol Drinking; Amino Acid Transport Systems, Acidic; Animals; Biogenic Monoamines; Disease Models, Animal; Dopamine; Ethanol; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Glutamate-Ammonia Ligase; Glutamic Acid; Glutamine; Male; Nucleus Accumbens; Prefrontal Cortex; Rats; Serotonin; Substance Withdrawal Syndrome | 2016 |
The Role of Presenilin-1 in the Excitotoxicity of Ethanol Withdrawal.
Topics: Amyloid Precursor Protein Secretases; Animals; Body Weight; Cell Death; Cell Line; Cell Survival; Enzyme Inhibitors; Ethanol; Gene Expression Regulation, Enzymologic; Glutamic Acid; Hippocampus; Male; Mice; Mitogen-Activated Protein Kinase 14; Prefrontal Cortex; Presenilin-1; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 2016 |
Glutamatergic neurotransmission in the prefrontal cortex mediates the suppressive effect of intra-prelimbic cortical infusion of BDNF on cocaine-seeking.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cocaine-Related Disorders; Glutamic Acid; Male; MAP Kinase Signaling System; Microinjections; Phenols; Piperidines; Prefrontal Cortex; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Self Administration; Substance Withdrawal Syndrome; Sulfonamides; Synaptic Transmission | 2016 |
Intra-LC microinjection of orexin type-1 receptor antagonist SB-334867 attenuates the expression of glutamate-induced opiate withdrawal like signs during the active phase in rats.
Topics: Animals; Benzoxazoles; Disease Models, Animal; Glutamic Acid; Locus Coeruleus; Male; Microinjections; Morphine; Naphthyridines; Orexin Receptor Antagonists; Orexins; Rats, Wistar; Substance Withdrawal Syndrome; Urea | 2017 |
Methamphetamine Addiction Vulnerability: The Glutamate, the Bad, and the Ugly.
Topics: Animals; Behavior, Addictive; Gene Knockdown Techniques; Glutamic Acid; Homer Scaffolding Proteins; Male; Methamphetamine; Mice; Mice, Inbred Strains; Microdialysis; Nucleus Accumbens; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Self Administration; Substance Withdrawal Syndrome | 2017 |
Influence of Volatile Anesthesia on the Release of Glutamate and other Amino Acids in the Nucleus Accumbens in a Rat Model of Alcohol Withdrawal: A Pilot Study.
Topics: Amino Acids; Anesthesia, Inhalation; Animals; Arginine; Aspartic Acid; Desflurane; Disease Models, Animal; Feeding Behavior; gamma-Aminobutyric Acid; Glutamic Acid; Isoflurane; Male; Microdialysis; Nucleus Accumbens; Pilot Projects; Rats, Wistar; Substance Withdrawal Syndrome; Time Factors; Volatilization | 2017 |
Negative Association Between MR-Spectroscopic Glutamate Markers and Gray Matter Volume After Alcohol Withdrawal in the Hippocampus: A Translational Study in Humans and Rats.
Topics: Adult; Alcohol Abstinence; Alcoholism; Animals; Aspartic Acid; Biomarkers; Female; Glutamic Acid; Gray Matter; Hippocampus; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Rats; Rats, Wistar; Species Specificity; Substance Withdrawal Syndrome; Translational Research, Biomedical | 2017 |
Enhanced ability of TRPV1 channels in regulating glutamatergic transmission after repeated morphine exposure in the nucleus accumbens of rat.
Topics: Animals; Capsaicin; Corpus Striatum; Excitatory Postsynaptic Potentials; Glutamic Acid; Male; Morphine; Narcotics; Neuronal Plasticity; Neurotransmitter Agents; Nucleus Accumbens; Piperidines; Presynaptic Terminals; Pyrazoles; Random Allocation; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Substance Withdrawal Syndrome; Synaptic Transmission; Tissue Culture Techniques; TRPV Cation Channels | 2017 |
Adaptation of brain glutamate plus glutamine during abstinence from chronic methamphetamine use.
Topics: Adaptation, Physiological; Adult; Amphetamine-Related Disorders; Brain; Drug Administration Schedule; Female; Follow-Up Studies; Glutamic Acid; Glutamine; Humans; Male; Methamphetamine; Substance Withdrawal Syndrome | 2008 |
In vivo evidence for alcohol-induced neurochemical changes in rat brain without protracted withdrawal, pronounced thiamine deficiency, or severe liver damage.
Topics: Animals; Basal Ganglia; Choline; Ethanol; Fatty Liver; Glutamic Acid; Glutamine; Glycogen Storage Disease; Liver; Magnetic Resonance Spectroscopy; Male; Rats; Rats, Wistar; Substance Withdrawal Syndrome; Thiamine; Thiamine Deficiency; Thiamine Monophosphate | 2009 |
Increased AMPA receptor GluR1 subunit incorporation in rat hippocampal CA1 synapses during benzodiazepine withdrawal.
Topics: Animals; Benzodiazepines; Disease Models, Animal; Glutamic Acid; Hippocampus; Male; Microscopy, Immunoelectron; Neuronal Plasticity; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Substance Withdrawal Syndrome; Substance-Related Disorders; Synapses; Synaptic Transmission; Up-Regulation | 2008 |
Renewed cocaine exposure produces transient alterations in nucleus accumbens AMPA receptor-mediated behavior.
Topics: Animals; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine Agonists; Dopamine Uptake Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Motor Activity; Neuronal Plasticity; Nucleus Accumbens; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Dopamine D1; Substance Withdrawal Syndrome; Synaptic Transmission | 2008 |
Repeated cocaine administration decreases 5-HT(2A) receptor-mediated serotonergic enhancement of synaptic activity in rat medial prefrontal cortex.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine Uptake Inhibitors; Drug Administration Schedule; Drug Interactions; Excitatory Postsynaptic Potentials; Glutamic Acid; GTP-Binding Proteins; Male; Organ Culture Techniques; Patch-Clamp Techniques; Prefrontal Cortex; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Serotonin; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Substance Withdrawal Syndrome; Synaptic Transmission | 2009 |
N-methyl-D-aspartate 2b receptor subtype (NR2B) promoter methylation in patients during alcohol withdrawal.
Topics: Adult; Alcohol-Induced Disorders, Nervous System; Alcoholism; Brain; Brain Chemistry; Cohort Studies; DNA Methylation; DNA Mutational Analysis; Epigenesis, Genetic; Gene Silencing; Genetic Testing; Genotype; Glutamic Acid; Humans; Male; Middle Aged; Promoter Regions, Genetic; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome | 2009 |
Alcohol exposure alters NMDAR function in the bed nucleus of the stria terminalis.
Topics: Alcohol-Related Disorders; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Central Nervous System Depressants; Ethanol; Excitatory Postsynaptic Potentials; Glutamic Acid; In Vitro Techniques; Kinetics; Male; Maze Learning; Mice; Mice, Inbred C57BL; Neurons; Patch-Clamp Techniques; Receptors, N-Methyl-D-Aspartate; Septal Nuclei; Substance Withdrawal Syndrome; Synapses | 2009 |
Cocaine-evoked synaptic plasticity: persistence in the VTA triggers adaptations in the NAc.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Glutamic Acid; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Net; Neural Pathways; Neuronal Plasticity; Nucleus Accumbens; Organ Culture Techniques; Receptors, Metabotropic Glutamate; Recurrence; Substance Withdrawal Syndrome; Synaptic Transmission; Ventral Tegmental Area | 2009 |
Calcium/calmodulin-dependent protein kinase II mediates hippocampal glutamatergic plasticity during benzodiazepine withdrawal.
Topics: Animals; Behavior, Animal; Benzodiazepines; Biophysical Phenomena; Biophysics; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Disease Models, Animal; Drug Interactions; Electric Stimulation; Enzyme Inhibitors; Excitatory Amino Acid Agents; Flurazepam; Gene Expression Regulation, Enzymologic; Glutamic Acid; Hippocampus; Hypnotics and Sedatives; In Vitro Techniques; Male; Neuronal Plasticity; Patch-Clamp Techniques; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Subcellular Fractions; Substance Withdrawal Syndrome; Time Factors | 2010 |
First evidence that drugs of abuse produce behavioral sensitization and cross sensitization in planarians.
Topics: Animals; Behavior, Animal; Caffeine; Central Nervous System Stimulants; Cocaine; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Glutamic Acid; Hypnotics and Sedatives; Methamphetamine; Motor Activity; Muscarinic Antagonists; Planarians; Scopolamine; Substance Withdrawal Syndrome; Substance-Related Disorders | 2010 |
Small conductance calcium-activated potassium type 2 channels regulate alcohol-associated plasticity of glutamatergic synapses.
Topics: Analysis of Variance; Animals; Animals, Newborn; Benzimidazoles; Calcium; Calcium Channel Agonists; Central Nervous System Depressants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Ethanol; Excitatory Postsynaptic Potentials; Gene Expression Regulation; Glutamic Acid; Hippocampus; Male; Mice; Neuronal Plasticity; Neurons; Organ Culture Techniques; Patch-Clamp Techniques; Propidium; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Small-Conductance Calcium-Activated Potassium Channels; Substance Withdrawal Syndrome; Synapses; Time Factors | 2011 |
Cocaine-induced plasticity in the nucleus accumbens is cell specific and develops without prolonged withdrawal.
Topics: Animals; Cocaine; Dendritic Spines; Electrophysiology; Excitatory Postsynaptic Potentials; Female; Glutamic Acid; Green Fluorescent Proteins; Injections, Intraperitoneal; Locomotion; Male; Mice; Mice, Transgenic; Motor Activity; Neuronal Plasticity; Neuropsychological Tests; Nucleus Accumbens; Random Allocation; Receptors, AMPA; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome; Time Factors | 2011 |
Chronic N-acetylcysteine during abstinence or extinction after cocaine self-administration produces enduring reductions in drug seeking.
Topics: Acetylcysteine; Animals; Cocaine; Cocaine-Related Disorders; Cues; Dose-Response Relationship, Drug; Drug-Seeking Behavior; Extinction, Psychological; Glutamic Acid; Homeostasis; Male; Rats; Rats, Sprague-Dawley; Recurrence; Self Administration; Substance Withdrawal Syndrome | 2011 |
MR spectroscopy in opiate maintenance therapy: association of glutamate with the number of previous withdrawals in the anterior cingulate cortex.
Topics: Adult; Analysis of Variance; Buprenorphine; Case-Control Studies; Female; Glutamic Acid; Gyrus Cinguli; Heroin Dependence; Humans; Magnetic Resonance Spectroscopy; Male; Methadone; Middle Aged; Narcotics; Substance Withdrawal Syndrome | 2012 |
Developmental and withdrawal effects of adolescent AAS exposure on the glutamatergic system in hamsters.
Topics: Adolescent; Aggression; Anabolic Agents; Androgens; Animals; Brain; Cricetinae; Disease Models, Animal; Drug Administration Schedule; Glutamic Acid; Humans; Hypothalamus; Male; Nandrolone; Nandrolone Decanoate; Neurons; Substance Withdrawal Syndrome; Testosterone; Time Factors; Vesicular Glutamate Transport Protein 2 | 2011 |
Effect of glutamate receptor antagonists microinjected into the nucleus accumbens on place aversion induced by naloxone in single-dose, morphine-treated rats.
Topics: Animals; Behavior, Animal; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Microinjections; Morphine; Morphine Dependence; Motivation; Naloxone; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Spatial Behavior; Substance Withdrawal Syndrome | 2011 |
Protective effect of Nigella sativa oil against tramadol-induced tolerance and dependence in mice: role of nitric oxide and oxidative stress.
Topics: Analgesics, Opioid; Animals; Antioxidants; Behavior, Animal; Brain; Drug Tolerance; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glutamic Acid; Glutathione; Male; Malondialdehyde; Mice; Narcotic Antagonists; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Opioid-Related Disorders; Oxidative Stress; Pain Threshold; Plant Oils; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome; Time Factors; Tramadol | 2011 |
Ethanol-induced loss-of-righting response during ethanol withdrawal in male and female rats: associations with alterations in Arc labeling.
Topics: Animals; Central Nervous System Depressants; Cytoskeletal Proteins; Data Interpretation, Statistical; Ethanol; Female; Glutamic Acid; Immunohistochemistry; Male; Motor Cortex; Nerve Tissue Proteins; Postural Balance; Rats; Rats, Sprague-Dawley; Sex Characteristics; Substance Withdrawal Syndrome | 2012 |
Translational magnetic resonance spectroscopy reveals excessive central glutamate levels during alcohol withdrawal in humans and rats.
Topics: Adult; Alcoholism; Animals; Case-Control Studies; Ethanol; Female; Glutamic Acid; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Prefrontal Cortex; Rats; Substance Withdrawal Syndrome | 2012 |
¹H NMR-based metabonomic analysis of brain in rats of morphine dependence and withdrawal intervention.
Topics: Animals; Brain; Energy Metabolism; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Magnetic Resonance Spectroscopy; Male; Metabolomics; Morphine; Morphine Dependence; Narcotics; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 2012 |
Ethanol withdrawal-induced brain metabolites and the pharmacological effects of acamprosate in mice lacking ENT1.
Topics: Acamprosate; Animals; Brain; Equilibrative Nucleoside Transporter 1; Ethanol; gamma-Aminobutyric Acid; Glutamic Acid; Magnetic Resonance Spectroscopy; Mice; Mice, Knockout; Phosphorylation; Substance Withdrawal Syndrome; Taurine | 2012 |
Chronic h1-antihistamine treatment increases seizure susceptibility after withdrawal by impairing glutamine synthetase.
Topics: Animals; Astrocytes; Blotting, Western; Chromatography, High Pressure Liquid; Convulsants; Electroshock; gamma-Aminobutyric Acid; Glutamate-Ammonia Ligase; Glutamic Acid; Glutamine; Histamine H1 Antagonists; Histidine Decarboxylase; Immunohistochemistry; Kindling, Neurologic; Male; Methionine Sulfoximine; Mice; Mice, Inbred C57BL; Mice, Knockout; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Seizures; Substance Withdrawal Syndrome | 2012 |
Adolescent rats are resistant to adaptations in excitatory and inhibitory mechanisms that modulate mesolimbic dopamine during nicotine withdrawal.
Topics: Adaptation, Physiological; Age Factors; Analysis of Variance; Animals; Chromatography, High Pressure Liquid; Dialysis; Dopamine; Electrochemistry; gamma-Aminobutyric Acid; Glutamic Acid; Limbic System; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Nucleus Accumbens; Rats; Rats, Wistar; Statistics as Topic; Substance Withdrawal Syndrome; Ventral Tegmental Area | 2012 |
Time course of cocaine-induced behavioral and neurochemical plasticity.
Topics: Animals; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dose-Response Relationship, Drug; Drug-Seeking Behavior; Glutamic Acid; Male; Neuronal Plasticity; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Recurrence; Self Administration; Substance Withdrawal Syndrome; Time Factors | 2014 |
Thalamic glutamatergic afferents into the rat basolateral amygdala exhibit increased presynaptic glutamate function following withdrawal from chronic intermittent ethanol.
Topics: Afferent Pathways; Amygdala; Animals; Ethanol; Excitatory Postsynaptic Potentials; Glutamic Acid; Male; Organ Culture Techniques; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Thalamus | 2013 |
Dopamine and glutamate release in the dorsolateral caudate putamen following withdrawal from cocaine self-administration in rats.
Topics: Animals; Caudate Nucleus; Chromatography, High Pressure Liquid; Cocaine; Dopamine; Glutamic Acid; Male; Microdialysis; Rats; Rats, Sprague-Dawley; Self Administration; Substance Withdrawal Syndrome | 2012 |
Inhibition of brain oxidative stress and inducible nitric oxide synthase expression by thymoquinone attenuates the development of morphine tolerance and dependence in mice.
Topics: Animals; Benzoquinones; Brain; Drug Tolerance; Glutamic Acid; Glutathione; Glutathione Peroxidase; Male; Malondialdehyde; Mice; Morphine Dependence; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitrites; Oxidative Stress; Substance Withdrawal Syndrome | 2013 |
Hyperalgesia during opioid abstinence: mediation by glutamate and substance p.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Gene Expression; Genes, fos; Glutamic Acid; Histocytochemistry; Hot Temperature; Hyperalgesia; Injections, Spinal; Male; Mice; Mice, Inbred C57BL; Morphine; Neurotransmitter Agents; Pain Measurement; Posterior Horn Cells; Reaction Time; Substance P; Substance Withdrawal Syndrome | 2002 |
Baclofen attenuates conditioned locomotion to cues associated with cocaine administration and stabilizes extracellular glutamate levels in rat nucleus accumbens.
Topics: Animals; Baclofen; Cocaine; Cocaine-Related Disorders; Conditioning, Psychological; Cues; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Extracellular Space; GABA Agonists; gamma-Aminobutyric Acid; Glutamic Acid; Male; Microdialysis; Motor Activity; Neurons; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Reward; Substance Withdrawal Syndrome; Synaptic Transmission | 2003 |
GABA transmission in the nucleus accumbens is altered after withdrawal from repeated cocaine.
Topics: Animals; Binding, Competitive; Chronic Disease; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine; Drug Administration Schedule; Extracellular Space; GABA Agonists; GABA Antagonists; GABA-B Receptor Agonists; GABA-B Receptor Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Guanosine 5'-O-(3-Thiotriphosphate); Male; Microdialysis; Nucleus Accumbens; Phosphorylation; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Substance Withdrawal Syndrome; Synaptic Transmission | 2003 |
Ethanol withdrawal hyper-responsiveness mediated by NMDA receptors in spinal cord motor neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cyclic AMP-Dependent Protein Kinases; Ethanol; Evoked Potentials, Motor; Excitatory Amino Acid Agonists; Glutamic Acid; In Vitro Techniques; Motor Neurons; N-Methylaspartate; Patch-Clamp Techniques; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Substance Withdrawal Syndrome | 2003 |
Neuroadaptations in cystine-glutamate exchange underlie cocaine relapse.
Topics: Acetylcysteine; Adaptation, Physiological; Analysis of Variance; Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Corpus Striatum; Cystine; Dose-Response Relationship, Drug; Expectorants; Extinction, Psychological; Extracellular Space; Glutamic Acid; Male; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Recurrence; Reinforcement, Psychology; Self Administration; Substance Withdrawal Syndrome; Time Factors | 2003 |
Morphine withdrawal increases glutamate uptake and surface expression of glutamate transporter GLT1 at hippocampal synapses.
Topics: Amino Acid Transport System X-AG; Animals; Astrocytes; Cells, Cultured; Excitatory Amino Acid Transporter 2; Excitatory Amino Acid Transporter 3; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Hippocampus; Male; Morphine; Morphine Dependence; Neurons; Presynaptic Terminals; Protein Transport; Rats; Rats, Sprague-Dawley; RNA, Messenger; Substance Withdrawal Syndrome; Symporters; Synapses; Synaptosomes; Up-Regulation | 2003 |
[Application of combination of capillary electrophoresis with laser-induced fluorescence: measurement of glutamate and arginine in PAG microdialytes of conscions morphine-withdrawal rats].
Topics: Animals; Arginine; Electrophoresis, Capillary; Fluorescence; Glutamic Acid; Lasers; Microdialysis; Morphine; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 2003 |
Nerve terminal glutamate immunoreactivity in the rat nucleus accumbens and ventral tegmental area after a short withdrawal from cocaine.
Topics: Animals; Cocaine; Glutamic Acid; Immunochemistry; Male; Motor Activity; Nucleus Accumbens; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Ventral Tegmental Area | 2004 |
Potential pleiotropic effects of Mpdz on vulnerability to seizures.
Topics: Amino Acid Motifs; Animals; Carrier Proteins; Chromosome Mapping; Convulsants; Ethanol; Female; gamma-Aminobutyric Acid; Genetic Predisposition to Disease; Glutamic Acid; Male; Membrane Proteins; Mice; Mice, Inbred Strains; Pentobarbital; Phenotype; Quantitative Trait, Heritable; Seizures; Species Specificity; Substance Withdrawal Syndrome | 2004 |
[Muscarinic receptors modulate the mRNA expression of NMDA receptors in brainstem and the release of glutamate in periaqueductal grey during morphine withdrawal in rats].
Topics: Animals; Brain Stem; Glutamic Acid; Male; Morphine; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Substance Withdrawal Syndrome | 2004 |
Rapid synaptic plasticity of glutamatergic synapses on dopamine neurons in the ventral tegmental area in response to acute amphetamine injection.
Topics: 2-Amino-5-phosphonovalerate; Age Factors; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amphetamine; Animals; Animals, Newborn; Behavior, Animal; Blotting, Western; Central Nervous System Stimulants; Dopamine; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; Glutamic Acid; In Vitro Techniques; Male; Membrane Potentials; Motor Activity; N-Methylaspartate; Neuronal Plasticity; Neurons; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome; Synapses; Time Factors; Transferrin; Ventral Tegmental Area | 2004 |
Imbalance between neuroexcitatory and neuroinhibitory amino acids causes craving for ethanol.
Topics: Alcoholism; Animals; Behavior, Addictive; Brain; Drug Tolerance; Ethanol; Excitatory Amino Acids; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Models, Animal; Neurotransmitter Agents; Rats; Substance Withdrawal Syndrome | 2004 |
CPP and amlodipine alter the decrease in basal acetylcholine and choline release by audiogenic stimulus in hippocampus of ethanol-withdrawn rats in vivo.
Topics: Acetylcholine; Acoustic Stimulation; Alcohol-Induced Disorders, Nervous System; Amlodipine; Animals; Body Weight; Calcium Channel Blockers; Choline; Disease Models, Animal; Down-Regulation; Drug Interactions; Epilepsy, Reflex; Ethanol; Excitatory Amino Acid Agonists; Glutamic Acid; Hippocampus; Male; Microdialysis; Neural Pathways; Piperazines; Rats; Rats, Wistar; Seizures; Substance Withdrawal Syndrome; Synaptic Transmission | 2004 |
Hyperresponsiveness on washout of volatile anesthetics from isolated spinal cord compared to withdrawal from ethanol.
Topics: Anesthetics, Inhalation; Animals; Aspartic Acid; Bronchial Hyperreactivity; Calcitonin Gene-Related Peptide; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Electric Stimulation; Enzyme Inhibitors; Ethanol; Excitatory Postsynaptic Potentials; Glutamic Acid; Indoles; Maleimides; Protein Kinase C; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P; Substance Withdrawal Syndrome | 2005 |
Morphine decreases extracellular levels of glutamate in the anterior cingulate cortex: an in vivo microdialysis study in freely moving rats.
Topics: Animals; Extracellular Fluid; Glutamic Acid; Gyrus Cinguli; Male; Microdialysis; Morphine; Motor Activity; Rats; Rats, Wistar; Substance Withdrawal Syndrome | 2005 |
Chronic ethanol exposure and protracted abstinence alter NMDA receptors in central amygdala.
Topics: Alcohol-Induced Disorders, Nervous System; Amygdala; Animals; Central Nervous System Depressants; Disease Models, Animal; Drug Administration Schedule; Ethanol; Excitatory Postsynaptic Potentials; Gene Expression Regulation; Glutamic Acid; Male; Organ Culture Techniques; Presynaptic Terminals; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Substance Withdrawal Syndrome; Synaptic Transmission | 2006 |
Indirect modulation by alpha7 nicotinic acetylcholine receptors of noradrenaline release in rat hippocampal slices: interaction with glutamate and GABA systems and effect of nicotine withdrawal.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Bacterial Toxins; Biological Transport; Conotoxins; Cyanobacteria Toxins; Dihydro-beta-Erythroidine; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Male; Marine Toxins; Microcystins; Neurons; Nicotine; Norepinephrine; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, Nicotinic; Substance Withdrawal Syndrome; Tetrodotoxin; Tropanes | 2006 |
Neuronal substrates of relapse to cocaine-seeking behavior: role of prefrontal cortex.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Dopamine; Electroencephalography; Evoked Potentials; Feedback; Glutamic Acid; Male; Motivation; Nerve Net; Neurons; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Recurrence; Self Administration; Substance Withdrawal Syndrome | 2005 |
Nicotine-induced changes of glutamate and arginine in naive and chronically alcoholized rats: an in vivo microdialysis study.
Topics: Alcohol-Induced Disorders, Nervous System; Animals; Arginine; Brain Chemistry; Central Nervous System Depressants; Chronic Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Ethanol; Extracellular Fluid; Glutamic Acid; Male; Microdialysis; Nicotine; Nicotinic Agonists; Nitric Oxide; Nucleus Accumbens; Rats; Rats, Wistar; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2006 |
Nicotine stimulation on extracellular glutamate levels in the nucleus accumbens of ethanol-withdrawn rats in vivo.
Topics: Alcoholic Intoxication; Animals; Ethanol; Extracellular Fluid; Glutamic Acid; Male; Nicotine; Nucleus Accumbens; Rats; Rats, Wistar; Substance Withdrawal Syndrome | 2006 |
Changes in levels of D1, D2, or NMDA receptors during withdrawal from brief or extended daily access to IV cocaine.
Topics: Adaptation, Physiological; Animals; Binding, Competitive; Brain Chemistry; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine; Dopamine Uptake Inhibitors; Drug Administration Schedule; Glutamic Acid; Injections, Intravenous; Male; Neural Pathways; Nucleus Accumbens; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome; Synaptic Transmission | 2007 |
Fos and glutamate AMPA receptor subunit coexpression associated with cue-elicited cocaine-seeking behavior in abstinent rats.
Topics: Animals; Biomarkers; Brain; Cocaine; Cocaine-Related Disorders; Cues; Dopamine Uptake Inhibitors; Exploratory Behavior; Glutamic Acid; Limbic System; Male; Protein Subunits; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Self Administration; Substance Withdrawal Syndrome; Synaptic Transmission; Up-Regulation | 2007 |
Cortical inhibition and excitation in abstinent cocaine-dependent patients: a transcranial magnetic stimulation study.
Topics: Adult; Brain; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Evoked Potentials, Motor; Excitatory Postsynaptic Potentials; Female; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Male; Middle Aged; Motor Cortex; Neural Inhibition; Substance Withdrawal Syndrome; Synaptic Transmission; Transcranial Magnetic Stimulation | 2007 |
Benzodiazepine withdrawal-induced glutamatergic plasticity involves up-regulation of GluR1-containing alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors in Hippocampal CA1 neurons.
Topics: Adaptor Proteins, Signal Transducing; Animals; Benzodiazepines; Cell Membrane; Cytoplasm; Flurazepam; Glutamic Acid; Hippocampus; Kainic Acid; Male; Membrane Potentials; Membrane Proteins; Neuronal Plasticity; Patch-Clamp Techniques; Protein Transport; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Spermine; Substance Withdrawal Syndrome; Synapses; Up-Regulation | 2007 |
A demonstration of naloxone-precipitated opiate withdrawal on single neurones in the morphine-tolerant/dependent rat brain.
Topics: Acetylcholine; Animals; Brain; Glutamates; Glutamic Acid; Humans; Male; Morphine Dependence; Naloxone; Neurons; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome | 1980 |
Ethanol withdrawal is associated with increased extracellular glutamate in the rat striatum.
Topics: Animals; Corpus Striatum; Diazepam; Dizocilpine Maleate; Ethanol; Glutamic Acid; Male; Microdialysis; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Time Factors | 1995 |
Increased locus coeruleus glutamate levels are associated with naloxone-precipitated withdrawal from butorphanol in the rat.
Topics: Animals; Butorphanol; Cerebral Ventricles; Glutamic Acid; Injections, Intraperitoneal; Injections, Intraventricular; Locus Coeruleus; Male; Microdialysis; Naloxone; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 1995 |
Calcium channel blockers improve hypoxia/hypoglycemia-induced impairment of rat hippocampal 2-deoxyglucose uptake in vitro after ethanol withdrawal.
Topics: Animals; Calcium Channel Blockers; Deoxyglucose; Dizocilpine Maleate; Dose-Response Relationship, Drug; Ethanol; Flunarizine; Glutamic Acid; Hippocampus; Hypoglycemia; Hypoxia; Male; Nifedipine; Rats; Rats, Wistar; Substance Withdrawal Syndrome | 1995 |
Opiate withdrawal increases glutamate and aspartate efflux in the locus coeruleus: an in vivo microdialysis study.
Topics: Animals; Aspartic Acid; Drug Implants; Extracellular Space; Glutamates; Glutamic Acid; Locus Coeruleus; Male; Microdialysis; Morphine; Naloxone; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 1994 |
Effect of morphine tolerance and abstinence on the binding of [3H]MK-801 to brain regions and spinal cord of the rat.
Topics: Animals; Brain; Dizocilpine Maleate; Down-Regulation; Drug Tolerance; Glutamates; Glutamic Acid; Glycine; Male; Morphine; Morphine Dependence; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Substance Withdrawal Syndrome | 1994 |
Naloxone-precipitated morphine withdrawal increases pontine glutamate levels in the rat.
Topics: Animals; Aspartic Acid; Dialysis; Drug Interactions; Glutamates; Glutamic Acid; Locus Coeruleus; Male; Morphine; Naloxone; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 1994 |
Long-term glutamate desensitization in locus coeruleus neurons and its role in opiate withdrawal.
Topics: Animals; Calcium; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glutamic Acid; In Vitro Techniques; Locus Coeruleus; Long-Term Potentiation; Male; Morphine; Neurons; Phosphoric Monoester Hydrolases; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Time Factors | 1995 |
Direct evidence for a role of glutamate in the expression of the opioid withdrawal syndrome.
Topics: Animals; Behavior, Animal; Dizocilpine Maleate; Glutamic Acid; Male; Morphine; Naloxone; Narcotics; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 1996 |
Spinal amino acid release and precipitated withdrawal in rats chronically infused with spinal morphine.
Topics: Amino Acids; Animals; Clonidine; Dizocilpine Maleate; Glutamic Acid; Glycine; Injections, Spinal; Male; Microdialysis; Morphine; Naloxone; Rats; Rats, Sprague-Dawley; Reaction Time; Spinal Cord; Substance Withdrawal Syndrome; Taurine; Time Factors | 1996 |
Inhibitory effects of diltiazem, an L-type Ca2+ channel blocker, on naloxone-increased glutamate levels in the locus coeruleus of opioid-dependent rats.
Topics: Animals; Butorphanol; Calcium Channel Blockers; Diltiazem; Glutamic Acid; Locus Coeruleus; Male; Microdialysis; Morphine; Morphine Dependence; Naloxone; Narcotic Antagonists; Opioid-Related Disorders; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 1996 |
Differential desensitization of mu- and delta- opioid receptors in selected neural pathways following chronic morphine treatment.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclases; Aminobutyrates; Analgesics; Animals; Brain; Caudate Nucleus; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glutamic Acid; Male; Morphine; Morphine Dependence; Naloxone; Narcotic Antagonists; Nucleus Accumbens; Oligopeptides; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Serotonin Receptor Agonists; Substance Withdrawal Syndrome; Thalamus | 1996 |
Regional and subunit specific changes in NMDA receptor mRNA and immunoreactivity in mouse brain following chronic ethanol ingestion.
Topics: Alcoholism; Animals; Brain; Cerebellum; Cerebral Cortex; Dizocilpine Maleate; Glutamic Acid; Hippocampus; Macromolecular Substances; Male; Mice; Mice, Inbred C57BL; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Substance Withdrawal Syndrome | 1996 |
Precipitated kappa-opioid receptor agonist withdrawal increase glutamate in rat locus coeruleus.
Topics: Analgesics; Analysis of Variance; Animals; Aspartic Acid; Benzeneacetamides; Butorphanol; Glutamic Acid; Injections, Intraventricular; Locus Coeruleus; Male; Microdialysis; Naloxone; Narcotic Antagonists; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Substance Withdrawal Syndrome | 1996 |
Sensitisation to repeated withdrawal, in mice treated chronically with diazepam, is blocked by an NMDA receptor antagonist.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anti-Anxiety Agents; Convulsants; Diazepam; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Mice; Mice, Inbred C57BL; Pentylenetetrazole; Receptors, N-Methyl-D-Aspartate; Seizures; Substance Withdrawal Syndrome; Synaptic Transmission | 1998 |
The role of glutamate in the locus coeruleus during opioid withdrawal and effects of H-7, a protein kinase inhibitor, on the action of glutamate in rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Butorphanol; Glutamic Acid; Infusions, Parenteral; Locus Coeruleus; Male; Microdialysis; Morphine Dependence; Motor Activity; Naloxone; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Substance-Related Disorders | 1998 |
Effect of precipitated withdrawal on extracellular glutamate and aspartate in the nucleus accumbens of chronically morphine-treated rats: an in vivo microdialysis study.
Topics: Animals; Aspartic Acid; Calcium; Extracellular Space; Glutamic Acid; Male; Microdialysis; Morphine; Naloxone; Narcotic Antagonists; Nucleus Accumbens; Rats; Rats, Wistar; Substance Withdrawal Syndrome | 1998 |
The GnRH increase following progesterone withdrawal is associated with an increased glutamatergic tone in the preoptic area of the ovariectomized ewe.
Topics: Animals; Female; Glutamic Acid; Gonadotropin-Releasing Hormone; Ovariectomy; Ovary; Preoptic Area; Progesterone; Secretory Rate; Sheep; Substance Withdrawal Syndrome | 1998 |
A comparison of the effects of clonidine and CNQX infusion into the locus coeruleus and the amygdala on naloxone-precipitated opiate withdrawal in the rat.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Adrenergic alpha-Agonists; Amygdala; Animals; Clonidine; Excitatory Amino Acid Antagonists; Glutamic Acid; Glutamine; Locus Coeruleus; Male; Morphine Dependence; N-Methylaspartate; Naloxone; Narcotic Antagonists; Norepinephrine; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 1998 |
Decreased presynaptic sensitivity to adenosine after cocaine withdrawal.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenosine; Affinity Labels; Animals; Cocaine; Dipyridamole; Dopamine Uptake Inhibitors; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; Male; Nucleus Accumbens; Phosphodiesterase Inhibitors; Presynaptic Terminals; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Stimulation, Chemical; Substance Withdrawal Syndrome; Substance-Related Disorders; Theophylline; Thioinosine; Vasodilator Agents; Xanthines | 1998 |
Mivazerol inhibits intrathecal release of glutamate evoked by halothane withdrawal in rats.
Topics: Adrenergic alpha-Agonists; Anesthesia; Anesthetics, Inhalation; Animals; Aspartic Acid; Blood Pressure; Glutamic Acid; Halothane; Heart Rate; Imidazoles; Male; Microdialysis; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance Withdrawal Syndrome | 1998 |
Reduced glutamate immunolabeling in the nucleus accumbens following extended withdrawal from self-administered cocaine.
Topics: Animals; Cocaine; gamma-Aminobutyric Acid; Glutamic Acid; Immunohistochemistry; Male; Microscopy, Electron; Nucleus Accumbens; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Self Administration; Substance Withdrawal Syndrome; Synaptic Vesicles; Time Factors | 1998 |
Autoradiography of [3H]glutamate binding during pentobarbital tolerance and withdrawal in the rat.
Topics: Animals; Autoradiography; Brain; Drug Tolerance; Glutamic Acid; Hypnotics and Sedatives; Male; Pentobarbital; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Tissue Distribution; Tritium | 1999 |
Glutamate uptake in mice bred for ethanol withdrawal severity.
Topics: Alcoholic Intoxication; Animals; Central Nervous System Depressants; Ethanol; Glutamic Acid; Handling, Psychological; Hippocampus; Kinetics; Male; Mice; Seizures; Substance Withdrawal Syndrome; Synaptosomes | 1999 |
Acamprosate decreases the hypermotility during repeated ethanol withdrawal.
Topics: Acamprosate; Alcohol Deterrents; Animals; Central Nervous System Depressants; Ethanol; Glutamic Acid; Male; Motor Activity; Nucleus Accumbens; Rats; Rats, Wistar; Substance Withdrawal Syndrome; Taurine | 1999 |
Presynaptic regulation of glutamate release in the ventral tegmental area during morphine withdrawal.
Topics: Animals; Excitatory Postsynaptic Potentials; Glutamic Acid; In Vitro Techniques; Morphine; Narcotics; Neural Inhibition; Presynaptic Terminals; Rats; Rats, Wistar; Receptors, GABA-B; Receptors, Metabotropic Glutamate; Receptors, Opioid, mu; Substance Withdrawal Syndrome; Tegmentum Mesencephali | 1999 |
Glutamate-induced increase of extracellular glutamate through N-methyl-D-aspartate receptors in ethanol withdrawal.
Topics: Animals; Corpus Striatum; Dizocilpine Maleate; Ethanol; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Extracellular Space; Feedback; Glutamic Acid; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome; Up-Regulation | 1999 |
Autoradiographic study of NMDA-displaceable [3H]glutamate and [3H]MK-801 binding during butorphanol withdrawal in the rat brain.
Topics: Animals; Autoradiography; Binding, Competitive; Brain Chemistry; Butorphanol; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Injections, Intraventricular; Male; N-Methylaspartate; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Tritium | 1999 |
Effect of repeated ethanol withdrawal on glutamate microdialysate in the hippocampus.
Topics: Amino Acids; Animals; Central Nervous System Depressants; Ethanol; Glutamic Acid; Hippocampus; Male; Microdialysis; Rats; Rats, Wistar; Substance Withdrawal Syndrome | 1999 |
Taurine blocks the glutamate increase in the nucleus accumbens microdialysate of ethanol-dependent rats.
Topics: Alcoholism; Animals; Arginine; Central Nervous System Depressants; Ethanol; gamma-Aminobutyric Acid; Glutamic Acid; Male; Nucleus Accumbens; Rats; Rats, Wistar; Substance Withdrawal Syndrome; Taurine | 2000 |
Chronic morphine treatment and withdrawal increase extracellular levels of norepinephrine in the rat bed nucleus of the stria terminalis.
Topics: Adrenergic alpha-Agonists; Animals; Brain; Brimonidine Tartrate; Extracellular Space; Glutamic Acid; In Vitro Techniques; Male; Microdialysis; Morphine; Morphine Dependence; Norepinephrine; Quinoxalines; Rats; Rats, Sprague-Dawley; Septal Nuclei; Substance Withdrawal Syndrome | 2000 |
Significance of glutamate and dopamine neurons in the ventral pallidum in the expression of behavioral sensitization to amphetamine.
Topics: Amphetamine; Animals; Aspartic Acid; Behavior, Animal; Central Nervous System Stimulants; Dizocilpine Maleate; Dopamine; Excitatory Amino Acid Antagonists; Globus Pallidus; Glutamic Acid; Male; Motor Activity; Neurons; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome | 2001 |
Further evidence for a role of NMDA receptors in the locus coeruleus in the expression of withdrawal syndrome from opioids.
Topics: Animals; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Extracellular Space; Glutamic Acid; Locus Coeruleus; Male; N-Methylaspartate; Naloxone; Narcotics; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome | 2001 |
Changes in the expression of glial glutamate transporters in the rat brain accompanied with morphine dependence and naloxone-precipitated withdrawal.
Topics: Amino Acid Transport System X-AG; Animals; ATP-Binding Cassette Transporters; Brain; Extracellular Space; Gene Expression Regulation; Glutamic Acid; Male; Morphine; Morphine Dependence; Naloxone; Neuroglia; Rats; Rats, Sprague-Dawley; RNA, Messenger; Substance Withdrawal Syndrome; Synaptic Transmission | 2001 |
Ischemia-induced glutamate release in rat frontoparietal cortex after chronic alcohol and withdrawal.
Topics: Alcoholism; Animals; Aspartic Acid; Central Nervous System Depressants; Dialysis Solutions; Ethanol; Glutamic Acid; Ischemic Attack, Transient; Male; Microdialysis; Parietal Lobe; Rats; Rats, Wistar; Substance Withdrawal Syndrome | 2002 |
Effects of tizanidine on morphine physical dependence: attenuation and intensification.
Topics: Adrenergic alpha-Agonists; Analgesics; Animals; Aspartic Acid; Behavior, Animal; Clonidine; Glutamates; Glutamic Acid; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine Dependence; Muscle Contraction; Muscle, Smooth; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome | 1992 |
Mapping rat brain structures activated during ethanol withdrawal: role of glutamate and NMDA receptors.
Topics: Animals; Brain; Brain Chemistry; Brain Mapping; Dizocilpine Maleate; Ethanol; Glutamates; Glutamic Acid; Male; Proto-Oncogene Proteins c-fos; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Second Messenger Systems; Stereoisomerism; Substance Withdrawal Syndrome | 1992 |
Opiate withdrawal-induced hyperactivity of locus coeruleus neurons is substantially mediated by augmented excitatory amino acid input.
Topics: Amino Acids; Animals; Brain Diseases; Electric Stimulation; Glutamates; Glutamic Acid; Infusion Pumps, Implantable; Kynurenic Acid; Locus Coeruleus; Male; Microinjections; Morphine; Naloxone; Neurons; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome | 1991 |