glutamic acid has been researched along with Nerve Pain in 100 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 15 (15.00) | 29.6817 |
| 2010's | 68 (68.00) | 24.3611 |
| 2020's | 17 (17.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hayashi, S; Kato, A; Mizuno, K; Morita, A; Nakata, E; Ohashi, K; Yamamura, K | 1 |
| Cortés-Montero, E; Garzón-Niño, J; Onetti, Y; Rodríguez-Muñoz, M; Sánchez-Blázquez, P | 1 |
| Cervetto, C; Di Cesare Mannelli, L; Ghelardini, C; Lucarini, E; Marcoli, M; Micheli, L; Parisio, C; Toti, A | 1 |
| Al-Khrasani, M; Essmat, N; Galambos, AR; Geda, O; Karádi, DÁ; Király, K; Lakatos, PP; Laufer, R; Szökő, É; Tábi, T; Zádori, ZS | 1 |
| Barrett, JE; Fontana, ACK; Temmermand, R | 1 |
| Bonanno, G; Bonifacino, T; Di Cesare Mannelli, L; Farina, C; Ghelardini, C; Micheli, L; Milanese, M; Scherz, MW; Torazza, C | 1 |
| Chen, DD; Jiang, YY; Lin, ZH; Ma, Y; Ren, KP; Yang, JX; Yin, MB; Zhao, WN | 1 |
| Abdelhaffez, AS; Ahmed, MA; Elbadr, MM; Farghaly, HSM | 1 |
| Deng, M; Ding, Z; Guo, Q; Huang, J; Kong, Y; Wang, J; Xu, W; Zou, W | 1 |
| Gong, ZH; Li, YL; Liang, XN; Peng, J; Su, RB; Wang, HB; Yu, G; Zhang, ZL | 1 |
| Antunes, FTT; Caminski, ES; Dallegrave, E; de Freitas, LM; de Souza, AH; Gomez, MV; Junior, CADS; Pereira, EMR | 1 |
| Huang, S; Li, L; Liang, S; Liu, W; Tao, J; Wang, Z; Yang, M; Yu, X | 1 |
| Chen, XM; Jiang, MH; Liang, SX; Liu, WT; Wang, ZF; Yu, XM; Zhang, LP; Zheng, MF | 1 |
| Chia, WT; Liao, WT; Lin, CR; Tseng, CC | 1 |
| Ba, X; Hao, Y; Huang, Z; Jiang, C; Jin, G; Wang, J; Wu, J; Yang, S | 1 |
| Chen, Z; Duan, S; Guo, F; Li, KY; Li, XJ; Li, XY; Li, YY; Liu, R; Ma, XL; Sun, H; Sun, L; Wen, MQ; Wu, MY; Xu, CL; Yu, YQ; Zhu, ZG | 1 |
| Cobos, EJ; Cortés-Montero, E; Garzón-Niño, J; Rodríguez-Muñoz, M; Ruiz-Cantero, MDC; Sánchez-Blázquez, P | 1 |
| Amodeo, P; Belardo, C; Boccella, S; Calignano, A; Cristiano, C; de Novellis, V; Di Marzo, V; Guida, F; Iannotta, M; Iannotti, FA; Infantino, R; Luongo, L; Maione, S; Marabese, I; Paino, S; Palazzo, E; Ricciardi, F; Vitale, RM | 1 |
| Ahmad, KA; Chen, J; Ma, L; Peng, S; Wang, YX; Wei, J; Zhao, M | 1 |
| Chen, H; Chen, SR; Huang, Y; Jin, D; Pan, HL; Zhang, GF | 1 |
| Farahmandfar, M; Janzadeh, A; Naghdi, N; Nasirinezhad, F; Saffarpour, S; Shaabani, M | 1 |
| Nasirinezhad, F; Saffarpour, S | 1 |
| Bjerrum, OJ; Gegelashvili, G; Heegaard, AM; Kristensen, PJ; Munro, G | 1 |
| Li, CB; Ren, CZ; Shi, XY; Tan, X; Wang, W; Wang, WZ; Yao, XY; Zhang, RW; Zou, Z | 1 |
| Avendaño, C; Fernández-Montoya, J; Negredo, P | 1 |
| Boccella, S; de Novellis, V; Farina, A; Guida, F; Iannotta, M; Luongo, L; Maione, S; Marabese, I; Palazzo, E; Serra, N | 1 |
| Kelly, CJ; Martina, M | 1 |
| Gong, ZH; Liang, XN; Su, RB; Yu, G; Zhang, ZL | 1 |
| Eisenach, JC; Hayashida, KI; Kimuram, M | 1 |
| Becker, R; Bilbao, A; Falfán-Melgoza, C; Leixner, S; Sack, M; Sartorius, A; Singaravelu, SK; Spanagel, R; Weber-Fahr, W | 1 |
| Cheriyan, J; Sheets, PL | 1 |
| Ariffin, MZ; Ibrahim, KM; Khanna, S; Lee, AT; Lee, RZ; Liu, EHC; Low, CM; Poon, SY; Thong, HK | 1 |
| Abbaszadeh, F; Dargahi, L; Fakhri, S; Jorjani, M | 1 |
| Kato, D; Obata, H; Saito, S; Suto, T | 1 |
| Antunes, GF; Assis, DV; Auada, AVV; de Andrade, EM; Fonoff, ET; Gouveia, FV; Lebrun, I; Lopes, PSS; Martinez, RCR; Pagano, RL | 1 |
| Andoh, T; Doi, A; Kato, G; Koga, K; Kume, T; Uta, D; Yoshimura, M | 1 |
| Adamante, G; Bochi, GV; Chávez-Olórtegui, C; da Silveira Prestes, G; Dal-Toé De Prá, S; Dalenogare, DP; Damiani, AP; Ferro, PR; Machado-de-Ávila, RA; Milioli, AM; Moraes de Andrade, V; Pereira, AL; Rigo, FK; Trevisan, G | 1 |
| Cao, P; Mao, Y; Mei, L; Niu, C; Tao, W; Wang, Y; Yin, W; Zhang, Z | 1 |
| Cherkas, PS; Chiang, CY; Coderre, TJ; Dostrovsky, JO; Kumar, N; Miyamoto, M; Sessle, BJ; Varathan, V | 1 |
| Cheng, J; Li, WG; Peng, Z; Wang, X; Xi Zhu, M; Xiao, X; Xu, TL; Yu, Y; Zeng, WZ | 1 |
| Cheng, JK; Chiou, LC; Ho, YC | 2 |
| Akimoto, N; Beppu, K; Honda, K; Imoto, K; Kido, MA; Matsuzaki, Y; Nakashima, S; Noda, M; Takano, Y; Ushijima, Y; Uta, D | 1 |
| Dimitrov, EL; Kohno, K; Kuo, J; Usdin, TB | 1 |
| Weng, HR; Yan, X; 严, 喜; 翁, 汉 | 1 |
| Balayssac, D; Bayet-Robert, M; Daulhac, L; Eschalier, A; Ferrier, J; Moulinoux, JP; Pereira, B; Pezet, D | 1 |
| Chiang, TR; Hung, KL; Wang, CC; Wang, SJ; Wang, YC | 1 |
| Hamada, A; Kawabe, R; Kuzumaki, N; Matsui, R; Narita, M; Okano, H; Suhara, Y; Yamashita, A; Yanase, M | 1 |
| Anton, F; Hanesch, U; Le Coz, GM | 1 |
| Li, H; Li, W; Wang, P | 1 |
| Ganev, EG; Hiruma-Lima, CA; Martins, DF; Mazzardo-Martins, L; Nishijima, CM; Rocha, LR; Santos, AR | 1 |
| Asgari, AR; Ghanbari, A; Jorjani, M; Naderi, A; Samandari, R; Zahed, R | 1 |
| Guo, X; Liu, Y; Shen, R; Shen, X; Wang, F; Wu, H; Xu, S; Zhao, Q | 1 |
| Lladó, J; Olmos, G | 1 |
| Bianchi, E; Cerretani, D; Ghelardini, C; Menicacci, C | 1 |
| Canta, A; Carozzi, VA; Chiorazzi, A | 1 |
| Beloushko, E; Bourbia, N; Pertovaara, A; Sagalajev, B; Wei, H | 1 |
| Balog, A; Majláth, Z; Tajti, J; Vécsei, L | 1 |
| Armbruster, A; Bauer, I; Bee, LA; Eulenburg, V; Hermanns, H; Minett, MS; Mittnacht, S; Werdehausen, R; Wood, JN | 1 |
| Brüning, CA; Duarte, MM; Gai, BM; Martini, F; Nogueira, CW; Sampaio, TB; Soares, SM | 1 |
| Cervetto, C; Di Cesare Mannelli, L; Ghelardini, C; Marcoli, M; Maura, G; Micheli, L; Zanardelli, M | 1 |
| Hisaoka-Nakashima, K; Kitamura, T; Morioka, N; Nakamura, Y; Nakata, Y; Zhang, FF | 1 |
| Eisenach, JC; Hayashida, K; Kimura, M; Morado-Urbina, CE; Peters, CM; Suto, T | 1 |
| Belardo, C; D'Aniello, A; de Bartolomeis, A; De Gregorio, D; de Novellis, V; Di Marzo, V; Guida, F; Iannotta, M; Lattanzi, R; Luongo, L; Maione, S; Marabese, I; Marmo, F; Napolitano, F; Piscitelli, F; Romano, R; Rossi, F; Usiello, A | 1 |
| Gong, ZH; Su, RB; Wang, HS; Wang, ZT; Yi, SP; Yu, G | 1 |
| Ding, CP; Wang, J; Wang, JY; Wang, T; Yu, J; Zeng, XY; Zhang, T | 1 |
| Bandegi, P; Coderre, TJ; Cornea, VM; Fung, JST; Jong, YI; Kumar, N; Laferrière, A; Mickeviciute, A; O'Malley, KL; Ribeiro-da-Silva, A; Vincent, K | 1 |
| Kerr, BJ; Yousuf, MS | 1 |
| Inoue, A; Ito, S; Nakazawa, T; Uchida, H; Yamamoto, T | 1 |
| Deng, Y; Qiao, X; Shi, T; Wang, J; Wei, X; Xu, M; Yang, C; Yang, D | 1 |
| Clark, IA; Vissel, B | 1 |
| Dal-Secco, D; Ludtke, DD; Martins, DF; Santos, ARS; Siteneski, A | 1 |
| Cheng, JK; Hou, SY; Huang, YH; Lin, CR; Wu, CH | 1 |
| Azizi, H; Fathollahi, Y; Rohampour, K; Semnanian, S | 1 |
| Murinson, BB | 1 |
| Li, CX; Ma, C; Yan, LP; Yi, JL | 1 |
| Carozzi, V; Cavaletti, G; Marmiroli, P | 1 |
| Mishra, R; Semwal, A; Sriram, D; Yogeeswari, P | 1 |
| Nie, H; Weng, HR | 1 |
| Abe, T; Ito, S; Katano, T; Kunori, S; Mabuchi, T; Matsumura, S; Nakazawa, T; Okuda-Ashitaka, E; Watanabe, M; Yamamoto, T | 1 |
| Berger, JV; Deumens, R; Goursaud, S; Hermans, E; Joosten, EA; Lavand'homme, P; Schäfer, S | 1 |
| Cao, XH; Chen, SR; Han, HD; Li, L; Lopez-Berestein, G; Pan, HL; Sood, AK | 1 |
| Malmierca, E; Martin, YB; Nuñez, A | 1 |
| Byun, HS; Chen, H; Chen, SR; Han, HD; Li, L; Lopez-Berestein, G; Pan, HL; Sood, AK; Zhou, HY | 1 |
| Mika, J; Osikowicz, M; Przewlocka, B | 1 |
| Babaniyi, OB; Barrett, LB; Bartels, K; Inquimbert, P; Scholz, J; Tegeder, I | 1 |
| Andó, RD; Sperlágh, B | 1 |
| Cardenas, DD; Cruz-Almeida, Y; Felix, ER; Martinez-Arizala, A; Pattany, PM; Perez, S; Widerström-Noga, E | 1 |
| Gao, M; Jiang, E; Weng, HR; Yan, X | 1 |
| Lim, G; Mao, J; Sung, B | 1 |
| Ito, S; Kitano, T; Kojima, H; Mabuchi, T; Matsumura, S; Minami, T; Nagano, T; Okuda-Ashitaka, E | 1 |
| Delaney, A; Fleetwood-Walker, SM; Garry, EM; Mitchell, R; Moss, A; Rosie, R | 1 |
| Mao, J | 1 |
| Coderre, TJ; Kumar, N; Lefebvre, CD; Yu, JS | 1 |
| Drouot, X; Keravel, Y; Lefaucheur, JP; Ménard-Lefaucheur, I; Nguyen, JP | 1 |
| Buist, A; Callaerts-Vegh, Z; Cik, M; D'Hooge, R; Daneels, G; Goris, I; Hampson, RM; Kass, S; Leo, S; Meert, T; Moechars, D; Rosenmund, C; van der Spek, P; Weston, MC | 1 |
| Jesse, CR; Nogueira, CW; Pinto, LG; Rocha, JB; Savegnago, L | 1 |
| Bert, L; Ghaemmaghami, C; Mertens, P; Perret-Liaudet, A; Renaud, B; Sindou, M | 1 |
| Ito, S; Minami, T; Okuda-Ashitaka, E | 1 |
| McEwen, BS | 1 |
12 review(s) available for glutamic acid and Nerve Pain
| Article | Year |
|---|---|
Glutamatergic systems in neuropathic pain and emerging non-opioid therapies.
Topics: Amino Acid Transport System X-AG; Animals; Astrocytes; Glutamic Acid; Neuralgia; Neurons | 2022 |
The Glutamatergic System in Primary Somatosensory Neurons and Its Involvement in Sensory Input-Dependent Plasticity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Ganglia, Sensory; Glutamic Acid; Humans; Kainic Acid; N-Methylaspartate; Neuralgia; Neuronal Plasticity; Receptors, AMPA; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Sensory Receptor Cells; Synaptic Transmission | 2017 |
Tumor necrosis factor alpha: a link between neuroinflammation and excitotoxicity.
Topics: Analgesics, Opioid; Animals; Astrocytes; Calcium; Cytokines; Glutamic Acid; Humans; Inflammation; Neuralgia; Neuroglia; Neuronal Plasticity; Neurons; Receptors, AMPA; Receptors, GABA-A; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Synaptic Transmission; Tumor Necrosis Factor-alpha | 2014 |
Chemotherapy-induced peripheral neuropathy: What do we know about mechanisms?
Topics: Antineoplastic Agents; DNA Damage; Ganglia, Spinal; Glutamic Acid; Humans; Ion Channels; Mitochondria; Mitogen-Activated Protein Kinases; Neuralgia; Neuroglia; Oxidative Stress; Peripheral Nervous System Diseases; Satellite Cells, Perineuronal; Schwann Cells; Sensory Receptor Cells; Signal Transduction | 2015 |
Drug targets of migraine and neuropathy: treatment of hyperexcitability.
Topics: Animals; Excitatory Amino Acid Agents; Glutamic Acid; Humans; Hyperalgesia; Kynurenine; Migraine Disorders; Neuralgia | 2015 |
The Role of Regulatory Transporters in Neuropathic Pain.
Topics: Animals; Biogenic Monoamines; Chlorides; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Membrane Transport Proteins; Neuralgia | 2016 |
Excess cerebral TNF causing glutamate excitotoxicity rationalizes treatment of neurodegenerative diseases and neurogenic pain by anti-TNF agents.
Topics: Animals; Cerebral Cortex; Glutamic Acid; Humans; Neuralgia; Neurodegenerative Diseases; Tumor Necrosis Factor-alpha | 2016 |
Focus on the role of Glutamate in the pathology of the peripheral nervous system.
Topics: Animals; Carboxypeptidases; Ganglia, Spinal; Glutamic Acid; Humans; Neuralgia; Nociceptors; Peripheral Nervous System Diseases; Receptors, Glutamate; Sensory Receptor Cells; Vesicular Glutamate Transport Proteins | 2008 |
Current approaches with the glutamatergic system as targets in the treatment of neuropathic pain.
Topics: Animals; Drug Delivery Systems; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Neuralgia; Pain; Treatment Outcome | 2009 |
The glutamatergic system as a target for neuropathic pain relief.
Topics: Analgesics; Animals; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Humans; Ligands; Neuralgia; Neuroglia; Receptors, Metabotropic Glutamate; Signal Transduction; Vesicular Glutamate Transport Proteins | 2013 |
Central and peripheral roles of prostaglandins in pain and their interactions with novel neuropeptides nociceptin and nocistatin.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acids; Brain; Cattle; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Drug Synergism; Glutamic Acid; Humans; Hyperalgesia; Inflammation; Isoenzymes; Membrane Proteins; Mice; Mice, Knockout; Models, Animal; Models, Biological; Neuralgia; Neuronal Plasticity; Nitric Oxide; Nociceptin; Nociceptors; Opioid Peptides; Pain; Peripheral Nerves; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Protein Precursors; Rats; Spinal Cord; Thromboxane-A Synthase | 2001 |
Plasticity of the hippocampus: adaptation to chronic stress and allostatic load.
Topics: Adaptation, Physiological; Adrenal Cortex; Aging; Animals; Atrophy; Brain Ischemia; Chronic Disease; Circadian Rhythm; Dendrites; Dentate Gyrus; Depression; Estrogens; Female; Glucocorticoids; Glutamic Acid; Hippocampus; Humans; Hypothalamo-Hypophyseal System; Male; Memory Disorders; Models, Animal; Neuralgia; Neurons; Pain; Pituitary-Adrenal System; Rats; Restraint, Physical; Seizures; Stress Disorders, Post-Traumatic; Stress, Physiological; Tumor Necrosis Factor-alpha | 2001 |
1 trial(s) available for glutamic acid and Nerve Pain
| Article | Year |
|---|---|
Motor cortex rTMS restores defective intracortical inhibition in chronic neuropathic pain.
Topics: Adult; Aged; Analgesia; Chronic Disease; Evoked Potentials, Motor; Female; Functional Laterality; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Male; Middle Aged; Models, Neurological; Motor Cortex; Neural Inhibition; Neural Pathways; Neuralgia; Peripheral Nervous System Diseases; Somatosensory Cortex; Synaptic Transmission; Transcranial Magnetic Stimulation; Treatment Outcome | 2006 |
87 other study(ies) available for glutamic acid and Nerve Pain
| Article | Year |
|---|---|
Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: de
Topics: Analgesics; Animals; Benzimidazoles; Drug Design; Drug Evaluation, Preclinical; Humans; Microsomes, Liver; Neuralgia; Nociceptin Receptor; Pyrroles; Rats; Receptors, Opioid; Structure-Activity Relationship | 2010 |
The σ1 Receptor and the HINT1 Protein Control α2δ1 Binding to Glutamate NMDA Receptors: Implications in Neuropathic Pain.
Topics: Animals; Glutamic Acid; Male; Mice; Neuralgia; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Sigma-1 Receptor | 2021 |
Neuronal alarmin IL-1α evokes astrocyte-mediated protective signals: Effectiveness in chemotherapy-induced neuropathic pain.
Topics: Alarmins; Animals; Antineoplastic Agents; Astrocytes; Glutamic Acid; Hyperalgesia; Interleukin-1alpha; Neuralgia; Neurons; Oxaliplatin; Rats; Rats, Sprague-Dawley; Spinal Cord | 2022 |
The Acute Antiallodynic Effect of Tolperisone in Rat Neuropathic Pain and Evaluation of Its Mechanism of Action.
Topics: Analgesics; Animals; Disease Models, Animal; Glutamic Acid; Neuralgia; Pregabalin; Rats; Tolperisone | 2022 |
Pharmacological Profile of MP-101, a Novel Non-racemic Mixture of R- and S-dimiracetam with Increased Potency in Rat Models of Cognition, Depression and Neuropathic Pain.
Topics: Animals; Cognition; D-Aspartic Acid; Depression; Glutamic Acid; N-Methylaspartate; Neuralgia; Rats | 2022 |
Caveolin-1 is essential for the increased release of glutamate in the anterior cingulate cortex in neuropathic pain mice.
Topics: Animals; Caveolin 1; Glutamic Acid; Gyrus Cinguli; Mice; Neuralgia; Neurons | 2023 |
Effect of single and repeated administration of amitriptyline on neuropathic pain model in rats: Focus on glutamatergic and upstream nitrergic systems.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Animals; Disease Models, Animal; Glutamic Acid; Male; Neuralgia; Nitric Oxide Synthase Type II; Nitrogen; Pain Threshold; Rats; Rats, Wistar | 2019 |
SNAP-25 Contributes to Neuropathic Pain by Regulation of VGLuT2 Expression in Rats.
Topics: Animals; Astrocytes; Botulinum Toxins, Type A; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; Down-Regulation; Glutamic Acid; Hyperalgesia; Male; Neuralgia; Protein Kinases; Rats; Signal Transduction; Spinal Cord; Spinal Cord Injuries; Synaptosomal-Associated Protein 25; Up-Regulation; Vesicular Glutamate Transport Protein 2 | 2019 |
Wnt1/β-catenin signaling upregulates spinal VGLUT2 expression to control neuropathic pain in mice.
Topics: Animals; beta Catenin; Glutamic Acid; Hyperalgesia; Immunohistochemistry; Injections, Spinal; Male; Mice; Mice, Inbred C57BL; Neuralgia; RNA, Small Interfering; Spinal Cord; Synaptosomes; Up-Regulation; Vesicular Glutamate Transport Protein 2; Wnt Signaling Pathway | 2020 |
Analgesic effects of the CTK 01512-2 toxin in different models of orofacial pain in rats.
Topics: Analgesics; Animals; Calcium Channels, N-Type; Capsaicin; Disease Models, Animal; Facial Pain; Freund's Adjuvant; Glutamic Acid; Hyperalgesia; Male; Neuralgia; omega-Conotoxins; Pain Measurement; Rats; Rats, Wistar; TRPA1 Cation Channel | 2020 |
Altered thalamic neurotransmitters metabolism and functional connectivity during the development of chronic constriction injury induced neuropathic pain.
Topics: Animals; Aspartic Acid; Constriction; Glutamic Acid; Hyperalgesia; Neuralgia; Neurotransmitter Agents; Rats; Thalamus; Wounds and Injuries | 2020 |
[Effect of wrist-ankle acupuncture on the expression of glutamate and NMDA receptor of the spinal dorsal horn in rats with neuropathic pain].
Topics: Acupuncture Therapy; Animals; Glutamic Acid; Lower Extremity; N-Methylaspartate; Neuralgia; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Cord Dorsal Horn; Upper Extremity | 2020 |
High-frequency spinal cord stimulation treatment attenuates the increase in spinal glutamate release and spinal miniature excitatory postsynaptic currents in rats with spared nerve injury-induced neuropathic pain.
Topics: Animals; Excitatory Postsynaptic Potentials; Glutamic Acid; Male; Miniature Postsynaptic Potentials; Motor Activity; Neuralgia; Neurons; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Cord Stimulation | 2020 |
Selective activation of metabotropic glutamate receptor 7 blocks paclitaxel-induced acute neuropathic pain and suppresses spinal glial reactivity in rats.
Topics: Acute Pain; Allosteric Regulation; Animals; Benzhydryl Compounds; Excitatory Amino Acid Agonists; Glutamic Acid; Male; Neuralgia; Paclitaxel; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Spinal Cord | 2021 |
Parabrachial nucleus circuit governs neuropathic pain-like behavior.
Topics: Animals; Disease Models, Animal; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; GABA Agonists; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Hyperalgesia; Inhibitory Postsynaptic Potentials; Male; Mice; Mice, Transgenic; Neural Pathways; Neuralgia; Neurons; Nociception; Optogenetics; Parabrachial Nucleus; Peroneal Nerve; Stereotaxic Techniques | 2020 |
Calmodulin Supports TRPA1 Channel Association with Opioid Receptors and Glutamate NMDA Receptors in the Nervous Tissue.
Topics: Animals; Calmodulin; Constriction, Pathologic; Formaldehyde; Glutamic Acid; Inflammation; Male; Mice; Nerve Tissue; Neuralgia; Organ Specificity; Protein Binding; Protein Subunits; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; TRPA1 Cation Channel | 2020 |
2-Pentadecyl-2-oxazoline ameliorates memory impairment and depression-like behaviour in neuropathic mice: possible role of adrenergic alpha2- and H3 histamine autoreceptors.
Topics: Amino Acid Sequence; Animals; Anxiety; Behavior, Animal; Chlorocebus aethiops; Cognition; COS Cells; Dentate Gyrus; Depression; Entorhinal Cortex; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Hyperalgesia; Locus Coeruleus; Long-Term Potentiation; Male; Memory Disorders; Mice, Inbred C57BL; Neuralgia; Norepinephrine; Oxazoles; Receptors, Adrenergic, alpha-2; Receptors, Histamine H3; Structural Homology, Protein | 2021 |
Spinal microglial β-endorphin signaling mediates IL-10 and exenatide-induced inhibition of synaptic plasticity in neuropathic pain.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; beta-Endorphin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Excitatory Postsynaptic Potentials; Exenatide; Glutamic Acid; Injections, Spinal; Interleukin-10; Microglia; Neuralgia; Neuronal Plasticity; Patch-Clamp Techniques; Rats; Receptors, Opioid, mu; Signal Transduction; Spinal Nerves; Synaptic Transmission | 2021 |
α2δ-1 Upregulation in Primary Sensory Neurons Promotes NMDA Receptor-Mediated Glutamatergic Input in Resiniferatoxin-Induced Neuropathy.
Topics: Animals; Calcium Channels, L-Type; Diterpenes; Ganglia, Spinal; Glutamic Acid; Hyperalgesia; Male; Mice; Neuralgia; Neuralgia, Postherpetic; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sensory Receptor Cells; Up-Regulation | 2021 |
In vivo evaluation of the hippocampal glutamate, GABA and the BDNF levels associated with spatial memory performance in a rodent model of neuropathic pain.
Topics: Analysis of Variance; Animals; Brain-Derived Neurotrophic Factor; Chromatography, High Pressure Liquid; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Hyperalgesia; Male; Maze Learning; Memory Disorders; Microdialysis; Neuralgia; Pain Threshold; Rats; Reaction Time | 2017 |
Functional interaction between N-methyl-D-aspartate receptor and ascorbic acid during neuropathic pain induced by chronic constriction injury of the sciatic nerve.
Topics: Analgesics; Animals; Ascorbic Acid; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Ketamine; Ligation; Male; Neuralgia; Pain Threshold; Peripheral Nerve Injuries; Rats; Receptors, N-Methyl-D-Aspartate; Sciatic Nerve | 2017 |
The β-lactam clavulanic acid mediates glutamate transport-sensitive pain relief in a rat model of neuropathic pain.
Topics: Analgesics; Animals; Astrocytes; Ceftriaxone; Cells, Cultured; Clavulanic Acid; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Transporter 2; Glutamic Acid; Humans; Male; Neuralgia; Pain Threshold; Rats; Rats, Sprague-Dawley; Spinal Cord; Up-Regulation | 2018 |
Enhancement in Tonically Active Glutamatergic Inputs to the Rostral Ventrolateral Medulla Contributes to Neuropathic Pain-Induced High Blood Pressure.
Topics: Animals; Excitatory Amino Acid Antagonists; Glutamic Acid; Glutaminase; Hyperalgesia; Hypertension; Male; Medulla Oblongata; Neuralgia; Paraventricular Hypothalamic Nucleus; Periaqueductal Gray; Rats, Sprague-Dawley; Receptors, Glutamate; Sympathetic Nervous System; Vesicular Glutamate Transport Protein 2 | 2017 |
Metabotropic glutamate receptor subtype 7 in the dorsal striatum oppositely modulates pain in sham and neuropathic rats.
Topics: Animals; Benzhydryl Compounds; Benzoxazoles; Corpus Striatum; Glutamic Acid; Hyperalgesia; Lidocaine; Male; Medulla Oblongata; Microinjections; Neuralgia; Neurons; Neuroprotective Agents; Pain; Rats; Receptors, Metabotropic Glutamate; Reticular Formation; Sciatic Nerve; Subthalamic Nucleus | 2018 |
Circuit-selective properties of glutamatergic inputs to the rat prelimbic cortex and their alterations in neuropathic pain.
Topics: Action Potentials; Animals; Animals, Newborn; Channelrhodopsins; Disease Models, Animal; Excitatory Amino Acid Antagonists; Functional Laterality; Glutamic Acid; Hippocampus; Male; Nerve Net; Neural Inhibition; Neural Pathways; Neuralgia; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Tetrodotoxin; Thalamus; Valine | 2018 |
Selective downregulation of vesicular glutamate transporter2 in ventral posterolateral nucleus of thalamus attenuates neuropathic mechanical allodynia in mice.
Topics: Animals; Down-Regulation; Glutamic Acid; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Neuralgia; Neurons; RNA, Small Interfering; Ventral Thalamic Nuclei; Vesicular Glutamate Transport Protein 2 | 2018 |
Blockade of α2-adrenergic or metabotropic glutamate receptors induces glutamate release in the locus coeruleus to activate descending inhibition in rats with chronic neuropathic hypersensitivity.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Idazoxan; Locus Coeruleus; Male; Neural Inhibition; Neuralgia; Pain Threshold; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Metabotropic Glutamate; Spinal Nerves | 2018 |
Longitudinal Structural and Functional Brain Network Alterations in a Mouse Model of Neuropathic Pain.
Topics: Animals; Brain; Disease Models, Animal; Glutamic Acid; Male; Mice; Multimodal Imaging; Neural Pathways; Neuralgia; Pain Threshold; Peripheral Nerve Injuries; Time Factors | 2018 |
Altered Excitability and Local Connectivity of mPFC-PAG Neurons in a Mouse Model of Neuropathic Pain.
Topics: Animals; Brain Mapping; Glutamic Acid; Limbic System; Male; Mice; Mice, Inbred C57BL; Neural Pathways; Neuralgia; Neurons; Pain Measurement; Patch-Clamp Techniques; Periaqueductal Gray; Photic Stimulation; Prefrontal Cortex; Sciatic Neuropathy | 2018 |
Forebrain medial septum sustains experimental neuropathic pain.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Disease Models, Animal; Glutamic Acid; Male; Medulla Oblongata; Neuralgia; Nociception; Pain Measurement; Prosencephalon; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Septal Nuclei | 2018 |
Astaxanthin attenuates neuroinflammation contributed to the neuropathic pain and motor dysfunction following compression spinal cord injury.
Topics: Animals; Cytokines; Disease Models, Animal; Glutamic Acid; Inflammation; Male; Motor Disorders; Neuralgia; Neuroimmunomodulation; p38 Mitogen-Activated Protein Kinases; Rats; Rats, Wistar; Recovery of Function; Signal Transduction; Spinal Cord; Spinal Cord Injuries; Xanthophylls | 2018 |
Tropomyosin Receptor Kinase B Receptor Activation in the Locus Coeruleus Restores Impairment of Endogenous Analgesia at a Late Stage Following Nerve Injury in Rats.
Topics: Analgesics; Animals; Disease Models, Animal; Flavones; gamma-Aminobutyric Acid; Glutamic Acid; Hyperalgesia; Locus Coeruleus; Male; Neuralgia; Pregabalin; Random Allocation; Rats, Sprague-Dawley; Receptor, trkB; Spinal Nerves | 2019 |
Neurochemical effects of motor cortex stimulation in the periaqueductal gray during neuropathic pain.
Topics: Analgesia; Animals; Bicuculline; Deep Brain Stimulation; Efferent Pathways; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Hyperalgesia; Male; Microdialysis; Microinjections; Motor Cortex; Neuralgia; Pain Threshold; Periaqueductal Gray; Rats; Rats, Wistar; Sciatic Nerve; Sciatica; Strychnine | 2019 |
Animal models of chronic pain increase spontaneous glutamatergic transmission in adult rat spinal dorsal horn in vitro and in vivo.
Topics: Animals; Chronic Pain; Disease Models, Animal; Excitatory Postsynaptic Potentials; Glutamic Acid; In Vitro Techniques; Inflammation; Male; Membrane Potentials; Models, Neurological; Neuralgia; Neuronal Plasticity; Nociception; Rats; Rats, Sprague-Dawley; Spinal Cord Dorsal Horn; Substantia Gelatinosa; Synaptic Transmission | 2019 |
TsNTxP, a non-toxic protein from Tityus serrulatus scorpion venom, induces antinociceptive effects by suppressing glutamate release in mice.
Topics: Analgesics; Animals; Arthropod Proteins; Female; Glutamic Acid; Male; Mice; Neuralgia; Scorpion Venoms; Scorpions; Spinal Cord; Synaptosomes | 2019 |
Microglia in the Primary Somatosensory Barrel Cortex Mediate Trigeminal Neuropathic Pain.
Topics: Animals; Disease Models, Animal; Glutamic Acid; Hyperalgesia; Mice; Microglia; Neuralgia; Neurons; Somatosensory Cortex | 2019 |
Systemic pregabalin attenuates facial hypersensitivity and noxious stimulus-evoked release of glutamate in medullary dorsal horn in a rodent model of trigeminal neuropathic pain.
Topics: Analgesics; Analysis of Variance; Animals; Chromatography, High Pressure Liquid; Data Interpretation, Statistical; Dental Pulp; Facial Pain; gamma-Aminobutyric Acid; Glutamic Acid; Male; Mediodorsal Thalamic Nucleus; Mice; Mice, Inbred C57BL; Microdialysis; Mustard Plant; Neuralgia; Physical Stimulation; Plant Oils; Pregabalin; Rats; Rats, Sprague-Dawley; Trigeminal Neuralgia | 2013 |
Serotonin facilitates peripheral pain sensitivity in a manner that depends on the nonproton ligand sensing domain of ASIC3 channel.
Topics: Acid Sensing Ion Channels; Action Potentials; Analysis of Variance; Animals; Calcium; CHO Cells; Cricetinae; Disease Models, Animal; Dose-Response Relationship, Drug; Ganglia, Spinal; Gene Expression Regulation; Glutamic Acid; Humans; Hydrogen-Ion Concentration; Ligands; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutagenesis, Site-Directed; Nerve Tissue Proteins; Neuralgia; Neurons; Pain Threshold; Protein Binding; Protein Structure, Tertiary; Proto-Oncogene Proteins c-fos; Protons; Radioligand Assay; Rats; Receptor, Serotonin, 5-HT2C; Serotonin; Serotonin Agents; Spinal Cord; Transfection; Tritium | 2013 |
Hypofunction of glutamatergic neurotransmission in the periaqueductal gray contributes to nerve-injury-induced neuropathic pain.
Topics: Animals; Bicuculline; Disease Models, Animal; Electric Stimulation; Excitatory Amino Acid Agents; Excitatory Postsynaptic Potentials; Glutamic Acid; In Vitro Techniques; Male; Membrane Potentials; Neuralgia; Neurons; Pain Measurement; Patch-Clamp Techniques; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Spinal Nerves; Synaptic Transmission; Tetrodotoxin | 2013 |
CCL-1 in the spinal cord contributes to neuropathic pain induced by nerve injury.
Topics: Analgesics; Animals; Cells, Cultured; Chemokine CCL1; Dizocilpine Maleate; Ganglia, Spinal; Gene Expression; Gene Knockdown Techniques; Glutamic Acid; Hyperalgesia; Injections, Spinal; Male; Mice; Mice, Transgenic; Neuralgia; Neuroglia; Nociception; Peripheral Nerve Injuries; Phosphorylation; Protein Processing, Post-Translational; Receptors, CCR8; Receptors, N-Methyl-D-Aspartate; RNA, Small Interfering; Spinal Cord | 2013 |
Neuropathic and inflammatory pain are modulated by tuberoinfundibular peptide of 39 residues.
Topics: Animals; Female; GABAergic Neurons; Glucose Transporter Type 2; Glutamic Acid; Hindlimb; Hyperalgesia; Inflammation; Locus Coeruleus; Male; Mice; Mice, Knockout; Mice, Transgenic; Neuralgia; Neurons; Neuropeptides; Pain Measurement; Receptor, Parathyroid Hormone, Type 2; Receptors, Adrenergic, alpha-2; Signal Transduction | 2013 |
Endogenous interleukin-1β in neuropathic rats enhances glutamate release from the primary afferents in the spinal dorsal horn through coupling with presynaptic N-methyl-D-aspartic acid receptors.
Topics: Animals; Ceramides; Glutamic Acid; Interleukin-1beta; Male; Myeloid Differentiation Factor 88; Neuralgia; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, Interleukin-1; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Sphingomyelin Phosphodiesterase | 2013 |
A polyamine-deficient diet prevents oxaliplatin-induced acute cold and mechanical hypersensitivity in rats.
Topics: Acute Disease; Animals; Antineoplastic Agents; Behavior, Animal; Cold Temperature; Diet; Glutamic Acid; Hyperalgesia; Immunoblotting; Magnetic Resonance Spectroscopy; Male; Metabolomics; Neuralgia; Organoplatinum Compounds; Oxaliplatin; Phosphorylation; Piperidines; Polyamines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Vasodilator Agents | 2013 |
Upregulation of presynaptic proteins and protein kinases associated with enhanced glutamate release from axonal terminals (synaptosomes) of the medial prefrontal cortex in rats with neuropathic pain.
Topics: Animals; Glutamic Acid; Male; Membrane Proteins; Neuralgia; Prefrontal Cortex; Presynaptic Terminals; Protein Kinases; Random Allocation; Rats; Rats, Sprague-Dawley; Synaptosomes; Up-Regulation | 2014 |
Astrocytic activation in the anterior cingulate cortex is critical for sleep disorder under neuropathic pain.
Topics: Animals; Astrocytes; Cell Membrane; Cells, Cultured; Extracellular Space; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Glutamic Acid; Gyrus Cinguli; Hot Temperature; Male; Mice; Mice, Inbred C57BL; Neuralgia; Oxygen; Physical Stimulation; Sciatic Neuropathy; Sleep Wake Disorders; Synapses; Wakefulness | 2014 |
Glucocorticoid-mediated enhancement of glutamatergic transmission may outweigh anti-inflammatory effects under conditions of neuropathic pain.
Topics: Animals; Anti-Inflammatory Agents; Body Weight; Cytokines; Disease Models, Animal; Gene Expression; Glucocorticoids; Glutamic Acid; Male; Mifepristone; Neuralgia; Pain Threshold; Peripheral Nerve Injuries; Rats; Receptors, Glucocorticoid; Synaptic Transmission | 2014 |
Upregulation of glutamatergic transmission in anterior cingulate cortex in the diabetic rats with neuropathic pain.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Diabetes Mellitus, Experimental; Excitatory Postsynaptic Potentials; Glutamic Acid; Gyrus Cinguli; Hot Temperature; Hyperalgesia; Male; Neuralgia; Neurons; Patch-Clamp Techniques; Physical Stimulation; Protein Kinase C; Rats, Sprague-Dawley; Receptors, Glutamate; Streptozocin; Synaptic Transmission; Touch; Up-Regulation | 2014 |
Citral: a monoterpene with prophylactic and therapeutic anti-nociceptive effects in experimental models of acute and chronic pain.
Topics: Acute Pain; Acyclic Monoterpenes; Analgesics; Animals; Capsaicin; Chronic Pain; Excitatory Amino Acids; Formaldehyde; Glutamic Acid; Hyperalgesia; Ischemia; Ketanserin; Male; Mice; Monoterpenes; Neuralgia; Pain, Postoperative; Rats, Wistar; Receptor, Serotonin, 5-HT2A; Serotonin 5-HT2 Receptor Antagonists; Stomach Ulcer; Substance P; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 2014 |
Estradiol attenuates spinal cord injury-related central pain by decreasing glutamate levels in thalamic VPL nucleus in male rats.
Topics: Analgesics; Animals; Disease Models, Animal; Estradiol; Glutamic Acid; Hyperalgesia; Male; Neuralgia; Pain Threshold; Rats; Rats, Wistar; Spinal Cord Injuries; Ventral Thalamic Nuclei | 2014 |
Menin regulates spinal glutamate-GABA balance through GAD65 contributing to neuropathic pain.
Topics: Animals; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamic Acid; Male; Mice; Mice, Inbred C57BL; Neuralgia; Peripheral Nerve Injuries; Proto-Oncogene Proteins; Spinal Cord | 2014 |
Spinal administration of mGluR5 antagonist prevents the onset of bortezomib induced neuropathic pain in rat.
Topics: Analgesics; Animals; Boronic Acids; Bortezomib; Ceftriaxone; Cell Line, Tumor; Cell Survival; Central Nervous System Agents; Disease Models, Animal; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Hyperalgesia; Injections, Spinal; Male; Neural Conduction; Neuralgia; Peripheral Nervous System Diseases; Pyrazines; Pyridines; Random Allocation; Rats; Receptor, Metabotropic Glutamate 5 | 2014 |
Bidirectional amygdaloid control of neuropathic hypersensitivity mediated by descending serotonergic pathways acting on spinal 5-HT3 and 5-HT1A receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amygdala; Animals; Dizocilpine Maleate; Glutamic Acid; Male; Neuralgia; Ondansetron; Pain Measurement; Peripheral Nervous System Diseases; Piperazines; Pyridines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1A; Receptors, N-Methyl-D-Aspartate; Receptors, Serotonin, 5-HT3; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT1 Receptor Antagonists; Serotonin 5-HT3 Receptor Agonists; Serotonin 5-HT3 Receptor Antagonists; Spinal Cord | 2015 |
Impairment of adenylyl cyclase-mediated glutamatergic synaptic plasticity in the periaqueductal grey in a rat model of neuropathic pain.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Cyclic AMP-Dependent Protein Kinases; Excitatory Postsynaptic Potentials; Glutamic Acid; Male; Neuralgia; Neuronal Plasticity; Periaqueductal Gray; Rats; Rats, Sprague-Dawley | 2015 |
The lidocaine metabolite N-ethylglycine has antinociceptive effects in experimental inflammatory and neuropathic pain.
Topics: Analgesics; Animals; Disease Models, Animal; Freund's Adjuvant; Glutamic Acid; Glycine; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Motor Activity; N-substituted Glycines; Neuralgia; Neurogenic Inflammation; Pain Measurement; Pain Threshold; Physical Stimulation; Posterior Horn Cells; Receptors, Glycine; Spinal Cord; Xenopus laevis | 2015 |
m-Trifluoromethyl-diphenyl diselenide, a multi-target selenium compound, prevented mechanical allodynia and depressive-like behavior in a mouse comorbid pain and depression model.
Topics: Adrenocorticotropic Hormone; Animals; Antidepressive Agents; Brain; Corticosterone; Cytokines; Depression; Disease Models, Animal; Functional Laterality; Glutamic Acid; Hyperalgesia; Male; Mice; Motor Activity; Neuralgia; Organosilicon Compounds; Peripheral Nerve Injuries; Serotonin; Swimming; Synaptosomes; Tritium | 2015 |
Oxaliplatin evokes P2X7-dependent glutamate release in the cerebral cortex: A pain mechanism mediated by Pannexin 1.
Topics: Analgesics; Animals; Antineoplastic Agents; Benzenesulfonates; Carbenoxolone; Cell Death; Cell Line, Tumor; Cerebral Cortex; Colonic Neoplasms; Connexins; Glutamic Acid; Humans; Male; Nerve Tissue Proteins; Neuralgia; Organoplatinum Compounds; Oxaliplatin; Purinergic P2X Receptor Antagonists; Pyridines; Rats, Sprague-Dawley; Receptors, Purinergic P2X7; Rosaniline Dyes; Synaptosomes; Tetrazoles | 2015 |
Tumor necrosis factor-mediated downregulation of spinal astrocytic connexin43 leads to increased glutamatergic neurotransmission and neuropathic pain in mice.
Topics: Animals; Astrocytes; Connexin 43; Down-Regulation; Excitatory Amino Acid Transporter 2; Glutamic Acid; Hindlimb; Ligation; Male; Mice; Neuralgia; Sciatic Nerve; Spinal Cord Dorsal Horn; Synaptic Transmission; Tumor Necrosis Factor-alpha | 2015 |
Impaired Pain-evoked Analgesia after Nerve Injury in Rats Reflects Altered Glutamate Regulation in the Locus Coeruleus.
Topics: Analgesia; Animals; Excitatory Amino Acid Transporter 2; Female; Glutamic Acid; Locus Coeruleus; Male; Neuralgia; Pain Measurement; Rats; Rats, Sprague-Dawley; Spinal Nerves | 2015 |
Palmitoylethanolamide reduces pain-related behaviors and restores glutamatergic synapses homeostasis in the medial prefrontal cortex of neuropathic mice.
Topics: Amides; Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Cells, Cultured; Electrophysiological Phenomena; Ethanolamines; Glutamic Acid; Homeostasis; Immobilization; Male; Mice; Microglia; Microinjections; Neuralgia; Neurons; Palmitic Acids; Prefrontal Cortex; Proto-Oncogene Proteins c-akt; Receptor, trkB; Signal Transduction; Synapses; Tail | 2015 |
Changes in VGLUT2 expression and function in pain-related supraspinal regions correlate with the pathogenesis of neuropathic pain in a mouse spared nerve injury model.
Topics: Animals; Brain; Coloring Agents; Disease Models, Animal; Gene Expression Regulation; Glutamic Acid; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Motor Activity; Neuralgia; Proto-Oncogene Proteins c-fos; Spinal Cord; Statistics, Nonparametric; Synaptosomes; Tibial Nerve; Trypan Blue; Vesicular Glutamate Transport Protein 2 | 2015 |
Red nucleus glutamate facilitates neuropathic allodynia induced by spared nerve injury through non-NMDA and metabotropic glutamate receptors.
Topics: Analysis of Variance; Animals; CD11b Antigen; Disease Models, Animal; Excitatory Amino Acid Antagonists; Glutamic Acid; Hyperalgesia; Male; Nerve Tissue Proteins; Neuralgia; Neuroglia; Neurons; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Red Nucleus | 2015 |
Intracellular mGluR5 plays a critical role in neuropathic pain.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Blotting, Western; Calcium; Cells, Cultured; Cytoskeletal Proteins; Excitatory Amino Acid Transporter 3; Glutamic Acid; Hyperalgesia; Immunohistochemistry; Injections, Spinal; Male; Microdialysis; Microscopy, Confocal; Microscopy, Electron; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morphine; Nerve Tissue Proteins; Neuralgia; Posterior Horn Cells; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Rats; Rats, Long-Evans; Receptor, Metabotropic Glutamate 5; Sciatic Nerve; Sciatic Neuropathy | 2016 |
Phosphorylation of NMDA receptor GluN2B subunit at Tyr1472 is important for trigeminal processing of itch.
Topics: Animals; Behavior, Animal; Gastrin-Releasing Peptide; Glutamic Acid; Mice; Neuralgia; Phosphorylation; Pruritus; Receptors, Bombesin; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Spinal Cord | 2016 |
Metabotropic Glutamate Receptor 7 (mGluR7) as a Target for Modulating Pain-evoked Activities of Neurons in the Hippocampal CA3 Region of Rats.
Topics: Analgesics, Non-Narcotic; Animals; Benzhydryl Compounds; CA3 Region, Hippocampal; Excitatory Amino Acid Agents; Glutamic Acid; Male; Microelectrodes; Neuralgia; Neurons; Nociceptive Pain; Pyridones; Rats, Wistar; Receptors, Metabotropic Glutamate; Sciatic Nerve; Synaptic Transmission | 2017 |
High-Intensity Swimming Exercise Decreases Glutamate-Induced Nociception by Activation of G-Protein-Coupled Receptors Inhibiting Phosphorylated Protein Kinase A.
Topics: Animals; Cyclic AMP-Dependent Protein Kinases; Glutamic Acid; Male; Mice; Naloxone; Neuralgia; Nociception; Pain Measurement; Phosphorylation; Physical Conditioning, Animal; Receptors, G-Protein-Coupled; Swimming; Xanthines | 2017 |
Pulsed radiofrequency attenuates diabetic neuropathic pain and suppresses formalin-evoked spinal glutamate release in rats.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Formaldehyde; Glutamic Acid; Male; Neuralgia; Pulsed Radiofrequency Treatment; Rats; Rats, Sprague-Dawley; Secretory Pathway | 2016 |
Peripheral nerve injury potentiates excitatory synaptic transmission in locus coeruleus neurons.
Topics: Action Potentials; Animals; Excitatory Postsynaptic Potentials; Female; Glutamic Acid; Locus Coeruleus; Male; Neuralgia; Neurons; Peripheral Nerve Injuries; Rats, Sprague-Dawley; Rats, Wistar; Sciatic Nerve | 2017 |
Botulinum toxin type A treatment of painful focal neuropathies: new evidence for efference of afferents.
Topics: Afferent Pathways; Botulinum Toxins, Type A; Calcitonin Gene-Related Peptide; Efferent Pathways; Exocytosis; Ganglia, Spinal; Glutamic Acid; Humans; Neuralgia; Neuromuscular Agents; Nociceptors; Peripheral Nerves; Peripheral Nervous System Diseases | 2008 |
[Effects of electroacupuncture on glutamate and aspartic acid contents in the dorsal root ganglion and spinal cord in rats with neuropathic pain].
Topics: Acupuncture Analgesia; Animals; Aspartic Acid; Electroacupuncture; Female; Ganglia, Spinal; Glutamic Acid; Humans; Male; Neuralgia; Neurotransmitter Agents; Pain Threshold; Random Allocation; Rats; Rats, Sprague-Dawley; Spinal Cord | 2008 |
Impaired glial glutamate uptake induces extrasynaptic glutamate spillover in the spinal sensory synapses of neuropathic rats.
Topics: Animals; Excitatory Postsynaptic Potentials; Glutamic Acid; In Vitro Techniques; Male; Neuralgia; Neuroglia; Neurons, Afferent; Pain Measurement; Patch-Clamp Techniques; Physical Stimulation; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sciatic Neuropathy; Spinal Cord; Synapses | 2010 |
Impairment of CaMKII activation and attenuation of neuropathic pain in mice lacking NR2B phosphorylated at Tyr1472.
Topics: Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Disease Models, Animal; Gene Knock-In Techniques; Glutamic Acid; Inflammation; Mice; Mice, Inbred C57BL; Models, Neurological; Neuralgia; Nitric Oxide Synthase Type I; Pain; Phosphorylation; Protein Kinase C; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Spinal Cord; Spinal Nerves | 2010 |
Enhanced neuroinflammation and pain hypersensitivity after peripheral nerve injury in rats expressing mutated superoxide dismutase 1.
Topics: Amino Acid Transport System X-AG; Animals; Behavior, Animal; Calcium-Binding Proteins; Female; Glial Fibrillary Acidic Protein; Glutamic Acid; Hyperalgesia; Inflammation; Interleukin-1beta; Membrane Glycoproteins; Microfilament Proteins; Microglia; NADPH Oxidase 2; NADPH Oxidases; Neuralgia; Pain Measurement; Peripheral Nerve Injuries; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Sciatic Nerve; Spinal Cord; Superoxide Dismutase; Toll-Like Receptor 4 | 2011 |
Up-regulation of Cavβ3 subunit in primary sensory neurons increases voltage-activated Ca2+ channel activity and nociceptive input in neuropathic pain.
Topics: Animals; Base Sequence; Calcium Channels; Down-Regulation; Ganglia, Spinal; Glutamic Acid; Male; Neuralgia; Nociception; Posterior Horn Cells; Protein Transport; Rats; Rats, Sprague-Dawley; Sensory Receptor Cells; Up-Regulation | 2012 |
Inhibitory control of nociceptive responses of trigeminal spinal nucleus cells by somatosensory corticofugal projection in rat.
Topics: Action Potentials; Afferent Pathways; Animals; Bicuculline; Biophysics; Capsaicin; Constriction; Disease Models, Animal; Electric Stimulation; Female; GABA-A Receptor Antagonists; Glutamic Acid; Glycine Agents; Hyperalgesia; Iontophoresis; Male; Neural Inhibition; Neuralgia; Nociceptors; Pain; Physical Stimulation; Rats; Rats, Sprague-Dawley; Somatosensory Cortex; Strychnine; Time Factors; Trigeminal Nucleus, Spinal | 2012 |
N-methyl-D-aspartate receptor- and calpain-mediated proteolytic cleavage of K+-Cl- cotransporter-2 impairs spinal chloride homeostasis in neuropathic pain.
Topics: Animals; Biological Transport; Calpain; Chlorides; Electrophysiology; Glutamic Acid; Homeostasis; K Cl- Cotransporters; Male; Neuralgia; Neuronal Plasticity; Pain; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; RNA, Small Interfering; Symporters; Synapses | 2012 |
Peripheral nerve injury produces a sustained shift in the balance between glutamate release and uptake in the dorsal horn of the spinal cord.
Topics: Animals; Chronic Pain; Glutamic Acid; Male; Neuralgia; Neurotransmitter Agents; Peripheral Nerve Injuries; Posterior Horn Cells; Rats; Rats, Sprague-Dawley | 2012 |
The role of glutamate release mediated by extrasynaptic P2X7 receptors in animal models of neuropathic pain.
Topics: Adenosine Triphosphate; Analysis of Variance; Animals; Disease Models, Animal; Glutamic Acid; Hyperalgesia; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuralgia; Receptors, Purinergic P2X7; Sciatic Nerve; Spinal Cord; Time Factors; Tritium | 2013 |
Metabolite concentrations in the anterior cingulate cortex predict high neuropathic pain impact after spinal cord injury.
Topics: Adult; Choline; Creatine; Glutamic Acid; Glutamine; Gyrus Cinguli; Humans; Inositol; Magnetic Resonance Spectroscopy; Neuralgia; Pain Management; Pain Measurement; Predictive Value of Tests; Prognosis; Reproducibility of Results; Severity of Illness Index; Spinal Cord Injuries | 2013 |
Endogenous activation of presynaptic NMDA receptors enhances glutamate release from the primary afferents in the spinal dorsal horn in a rat model of neuropathic pain.
Topics: Animals; Behavior, Animal; Excitatory Postsynaptic Potentials; Glutamic Acid; Ligation; Male; N-Methylaspartate; Neuralgia; Posterior Horn Cells; Protein Kinase C; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Serine; Spinal Nerves; Synapses | 2013 |
Altered expression and uptake activity of spinal glutamate transporters after nerve injury contribute to the pathogenesis of neuropathic pain in rats.
Topics: Amino Acid Transport System X-AG; Animals; Behavior, Animal; Biological Transport; Carbazoles; Constriction; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Transporter 2; Flavonoids; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Hyperalgesia; Indole Alkaloids; Kinetics; Male; Mitogen-Activated Protein Kinases; Neuralgia; Peripheral Nerves; Rats; Rats, Sprague-Dawley; Receptor Protein-Tyrosine Kinases; Riluzole; Spinal Cord; Symporters; Up-Regulation | 2003 |
Attenuation of neuropathic pain by the nociceptin/orphanin FQ antagonist JTC-801 is mediated by inhibition of nitric oxide production.
Topics: Aminoquinolines; Animals; Benzamides; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Fluorescein; Fluorescence; Fluorescent Dyes; Functional Laterality; Glutamic Acid; Hyperalgesia; In Vitro Techniques; Male; Mice; Mice, Knockout; NADPH Dehydrogenase; Neuralgia; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nociceptin; Opioid Peptides; Peptide Fragments; Reaction Time; Spinal Cord; Spinal Cord Injuries; Time Factors | 2003 |
Specific involvement in neuropathic pain of AMPA receptors and adapter proteins for the GluR2 subunit.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Carrier Proteins; Cell Membrane; Chronic Disease; Cytoskeletal Proteins; Excitatory Amino Acid Antagonists; Functional Laterality; Glutamic Acid; Hyperalgesia; Male; N-Ethylmaleimide-Sensitive Proteins; Neuralgia; Nuclear Proteins; Pain Threshold; Peptides; Peripheral Nervous System Diseases; Protein Binding; Protein Subunits; Protein Transport; Rats; Rats, Wistar; Receptors, AMPA; Recombinant Fusion Proteins; Reflex; RNA, Messenger; Synaptic Transmission; Vesicular Transport Proteins | 2003 |
Opioid tolerance and neuroplasticity.
Topics: Amino Acid Transport System X-AG; Analgesics, Opioid; Animals; Apoptosis; Drug Tolerance; Glutamic Acid; Homeostasis; Humans; Nervous System Diseases; Neuralgia; Neuronal Plasticity; Opioid-Related Disorders | 2004 |
Evidence that gabapentin reduces neuropathic pain by inhibiting the spinal release of glutamate.
Topics: Amines; Analgesics; Animals; Aspartic Acid; Chronic Disease; Cyclohexanecarboxylic Acids; Excitatory Amino Acid Antagonists; Foot; Gabapentin; gamma-Aminobutyric Acid; Glutamic Acid; Injections, Intraperitoneal; Injections, Spinal; Male; Neuralgia; Rats; Rats, Long-Evans; Spinal Cord; Spinal Cord Compression | 2005 |
Vesicular glutamate transporter VGLUT2 expression levels control quantal size and neuropathic pain.
Topics: Animals; Cells, Cultured; Chronic Disease; Disease Models, Animal; Excitatory Postsynaptic Potentials; Genes, Lethal; Glutamic Acid; Hippocampus; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuralgia; Pain Measurement; Peripheral Nervous System Diseases; Presynaptic Terminals; Synaptic Transmission; Synaptic Vesicles; Thalamus; Vesicular Glutamate Transport Protein 2 | 2006 |
Diphenyl diselenide attenuates acute thermal hyperalgesia and persistent inflammatory and neuropathic pain behavior in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Benzene Derivatives; Bradykinin; Dinoprostone; Freund's Adjuvant; Glutamic Acid; Hyperalgesia; Inflammation Mediators; Male; Mice; N-Methylaspartate; Neuralgia; Neurogenic Inflammation; Nociceptors; Organoselenium Compounds; Pain Measurement; Pain Threshold; Peripheral Nervous System Diseases; Sciatic Neuropathy | 2007 |
Amino acids in spinal dorsal horn of patients during surgery for neuropathic pain or spasticity.
Topics: Amino Acids; Aspartic Acid; Chromatography, High Pressure Liquid; Extracellular Space; Feasibility Studies; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Humans; Intraoperative Period; Microdialysis; Muscle Spasticity; Neuralgia; Peripheral Nervous System Diseases; Spinal Cord | 2000 |