Compounds > glutamic acid

glutamic acid and Nerve Degeneration

glutamic acid has been researched along with Nerve Degeneration in 516 studies

Research

Studies (516)

TimeframeStudies, this research(%)All Research%
pre-199019 (3.68)18.7374
1990's129 (25.00)18.2507
2000's267 (51.74)29.6817
2010's96 (18.60)24.3611
2020's5 (0.97)2.80

Authors

AuthorsStudies
Chang, CY; Chen, MF; Chiou, TW; Chiu, IM; Harn, HJ; Ho, TJ; Li, X; Lin, SZ; Liu, CA; Su, HL; Ting, HC; Tsai, YJ; Yang, HI1
Bar-Or, A; Bueno, M; Charabati, M; de Faria Junior, O; Drake, SS; Dumas, A; Fournier, AE; Galloway, DA; Juźwik, CA; Lécuyer, MA; Moore, C; Morquette, B; Paradis-Isler, N; Prat, A; Rambaldi, I; Vallières, L; Zandee, S; Zhang, Y1
Alimirah, F; Campisi, J; Davalos, AR; Desprez, PY; Gan, L; Limbad, C; Oron, TR; Tracy, TE1
Akella, JS; Barr, MM; Bellotti, S; Golden, A; Gu, A; Morash, M; O'Hagan, R; Power, KM; Ramadan, YH; Ross, N; Smith, HE; Walsh, JD; Zhang, W1
Idrizi, A; Mano, I; Mendelowitz, ZZ1
Katagi, M; Kojima, H; Nakae, Y; Ohashi, N; Okano, J; Suzuki, Y; Terashima, T1
Egger, V; Frommherz, I; Grosche, A; Haydon, PG; Hirrlinger, J; Illes, P; Jägle, H; Pannicke, T; Pfrieger, FW; Rupprecht, V; Volz, C; Wagner, L1
Nikhil, K; Shah, K1
Hattori, T; Hori, O; Ishii, H; Kitao, Y; Le, TM; Roboon, J; Ta, HM; Takarada-Iemata, M; Tamatani, T1
Dawson, TM; Dawson, VL1
Butt, AM; da Silva, AB; da Silva, VDA; David, JM; David, JP; Dos Santos Souza, C; Dos Santos, CC; Grangeiro, MS; Lima Costa, S; Lima Pereira, EP; Ribeiro Figueiredo, DD; Sampaio, GP1
Genrikhs, EE; Isaev, NK; Kapkaeva, MR; Stelmashook, EV; Voronkov, DN1
Choudhary, B; Mandelkow, E; Mandelkow, EM; Pir, GJ1
Balu, DT; Cantlon, A; Chen, Z; El Fatimy, R; Elkhal, A; Gongala, S; Krichevsky, AM; Li, S; Mushannen, T; Rabinovsky, R; Selkoe, DJ; Sonntag, KC; Walsh, DM; Wei, Z1
Bronfman, FC; Catalán, RJ; Court, FA; Hernández, DE; Moya-Alvarado, G; Salvadores, NA1
Morioka, H; Nishio, R; Takeda, A; Takeuchi, A; Tamano, H1
Ahmed, T; Becker, JL; Chowdhury, A; Diaz, K; Feldmann, KG; Haider, S; Mano, I; McAlpin, N; Mehta, MG; Richard Xia, JX1
Banks, RE; Domínguez, DC1
Green, L; Maguire, G; Mella, R; Paler, L; Valcarcel, M; Villace, P1
Kim, C; Kim, D; Kim, Y; Ko, YU; Lee, J; Oh, YJ; Yun, N1
Kouroupi, G; Koutsoudaki, PN; Matsas, R; Miltiadous, P; Stamatakis, A; Stylianopoulou, F1
Akimoto, N; Beppu, K; Fujita, K; Ifuku, M; Kido, MA; Kojima, Y; Kosai, Y; Mori, Y; Nabekura, J; Noda, M; Okuno, Y; Shinagawa, R; Sprengel, R; Yamakawa, Y1
Morales, I; Rodriguez, M; Rodriguez-Sabate, C; Sanchez, A; Yanos, C1
Freire, MA1
Chen, CM; Cherng, CH; Huh, B; Kuo, CP; Liaw, WJ; Lin, BF; Wen, LL; Wong, CS; Wu, CT; Yeh, CC1
de Wit, SJ; Hamann, J; Huitinga, I; Melief, J; Swaab, D; Teunissen, C; Uitdehaag, BM; van Eden, CG1
Cho, SW; Choi, J; Choi, SY; Hahn, HG; Han, AR; Kim, EA1
Fujiwara, T; Morimoto, K3
Annweiler, C; Bartha, R; Beauchet, O; Brugg, B; Peyrin, JM1
Luo, J; Pepperberg, DR; Qin, Z; Tavassoli, E; Thatcher, GR; Vandevrede, L; Yue, L1
Górska, A; Gołembiowska, K; Noworyta-Sokołowska, K1
Ayalon, G; Bustos, D; Gogineni, A; Hanson, JE; Jubb, AM; Kirkpatrick, DS; Larson, JL; Lee, SH; Lewcock, JW; Li, H; Ngu, H; Pozniak, CD; Scearce-Levie, K; Sengupta Ghosh, A; Solanoy, H; Weimer, RM; Wu, J; Zhou, Q1
Chen, HZ; Cui, YY; Feng, XM; Li, H; Qiu, Y; Tan, PP; Yuan, HH; Zhou, W; Zhu, X1
Bressan, RA; Kim, MO; Lee, HY; Shah, SA; Yun, DJ1
Adame, A; Campioni, S; Gage, FH; Gerez, J; Jensen, PH; Mante, M; Masliah, E; Nuber, S; Overk, CR; Patrick, C; Picotti, P; Riek, R; Rockenstein, E; Trejo-Morales, M; Ubhi, K; Winkler, J; Winner, B1
Kawanokuchi, J; Mizuno, T; Noda, M; Parajuli, B; Sonobe, Y; Suzumura, A; Takeuchi, H; Takii, K1
Baraka, AM; Dief, AE; Elshorbagy, AK; Kamha, ES1
Angelucci, F; Bernardini, S; Caltagirone, C; Croce, N1
Fang, Y; Fung, CK; Iu, CY; Lai, KW; Li, HW; Lui, CN; Xi, N; Yung, KK; Zou, Y1
Boger, HA; Farrand, AQ; Gregory, RA; Helke, KL; Scofield, MD1
Aida, T; Harada, T; Namekata, K; Shinagawa, R; Takeda, T; Tanaka, K; Yanagisawa, M1
Abdel-Aziz, K; Altmann, DR; Ciccarelli, O; Day, BL; Peters, AL; Schneider, T; Solanky, BS; Thompson, AJ; Wheeler-Kingshott, CA; Yiannakas, MC1
Ahmed, T; Amjad, U; An, J; Asemota, D; Del Rosario, JS; Feldmann, KG; Ko, B; Mahmud, T; Mano, I; Mei, S; Salama, M1
Corfas, G; Wan, G1
Mavri, J; Pavlin, M; Repič, M; Vianello, R1
Liu, QR; Reiner, D; Shen, H; Wang, Y; Wu, KJ; Yu, SJ1
Broggini, T; Buchfelder, M; Eyüpoglu, IY; Fan, Z; Savaskan, NE1
Cai, X; Chen, D; Gao, H; Jin, K; Liao, J; Liu, X; Ma, L; Tang, B; Wang, Q; Wei, X; Xia, Y; Xu, Y; Zhang, Z; Zou, J1
King, AE; Kirkcaldie, MT; Vickers, JC; Woodhouse, A1
Bäckman, CM; Boger, HA; Farrand, AQ; Gregory, RA; Helke, KL1
Kujawa, SG; Liberman, MC1
Colic, M; Cvetanovic, A; Kostic, M; Stojanovic, I; Zivkovic, N1
Morgan, JI; Wei, P; Wu, HY1
Candelario-Jalil, E; de Oliveira, AC; Fiebich, BL; Saliba, SW; Santos, RP; Teixeira, AL; Vieira, EL; Vieira, LB1
Bañuelos, C; Benavidez, J; Castañeda, MT; Colom, LV; García-Hernández, A; Hernandez, S; Lehker, C; Mounsey, S; Puras, G1
Boeck, CR; Ghisleni, G; Mioranzza, S; Porciúncula, LO; Rocha, JB; Souza, DO1
Kuramoto, N; Nagashima, R; Ogita, K; Sugiyama, C; Yoneyama, M1
Grieb, P; Matyja, E; Nagańska, E; Rafałowska, J; Taraszewska, A1
Devinney, MJ; Dineley, KE; Reynolds, IJ; Rintoul, GL; Zeak, JA1
Akaike, A; Fujii, T; Izumi, Y; Kume, T; Niidome, T; Ohgi, Y; Sugimoto, H; Takada-Takatori, Y1
Hara, H; Ikeda, T; Inokuchi, Y; Kato, A; Kudo, T; Nakajima, Y; Oku, H; Okuno, T; Sakaguchi, G; Shimazawa, M; Sugiyama, T; Takeda, M1
Barkhof, F; Geurts, JJ1
Jiang, H; Shi, J; Tian, S; Zeng, Y1
Bérubé-Carrière, N; Dal Bo, G; Descarries, L; Leo, D; Lévesque, D; Mendez, JA; Riad, M; Trudeau, LE1
Doi, Y; Jin, S; Kawanokuchi, J; Liang, J; Mizuno, T; Sawada, M; Suzuki, H; Suzumura, A; Takeuchi, H1
Irmady, K; Narayanan, KL; Subramaniam, S; Unsicker, K; von Bohlen und Halbach, O1
Bissette, G; Feng, YZ; Huang, J; Regunathan, S; Wang, WP; Zhu, MY1
Alekseenko, AV; Fedorovich, SV; Waseem, TV1
Braz, MH; Chatterjee, S; Figueiredo, C; Pais, TF; Peixoto, R1
Bruno, AN; Chagastelles, P; Frozza, RL; Gerhardt, D; Grudzinski, PB; Hoppe, JB; Horn, AP; Lenz, G; Nardi, NB; Salbego, C1
Baudry, M; Bi, X; Cheung, S; Galeano, J; Liao, G; Nguyen, N; Zhou, M1
Agnati, LF; Fuxe, K; Genedani, S; Guidolin, D; Leo, G; Piron, L; Rivera, A1
Davanger, S; Manahan-Vaughan, D; Mulle, C; Ottersen, OP; Storm-Mathisen, J1
Barbieri, M; Belluzzi, O; Binaschi, A; Buzzi, A; Cifelli, P; Coffin, JD; Marzola, A; Paradiso, B; Rodi, D; Simonato, M; Zucchini, S1
Behl, C; Hajieva, P; Kuhlmann, C; Luhmann, HJ1
Guo, Y; Li, B; Li, C; Sun, M; Yu, J; Zhang, Y1
Budka, H; Gelpi, E; Hayakawa, H; Izumo, S; Kubota, R; Xing, HQ1
Suzumura, A1
Ha, JS; Kwon, KS; Lee, CS; Maeng, JS; Park, SS1
Kiernan, MC; Vucic, S1
Kiernan, MC1
Bernardi, G; Carrì, MT; Centonze, D; Cozzolino, M; De Chiara, V; Maccarrone, M; Mercuri, NB; Musella, A; Rossi, S1
Lin, N; Liu, C; Qiu, Y; Wu, B1
Aroniadou-Anderjaska, V; Braga, MF; Figueiredo, TH; Fritsch, B; Qashu, F; Rogawski, MA1
Blumenthal, TD; Liu, C; Lyall, A; Swanson, J; Turner, CP1
Cheng, ZJ; Epstein, PN; Harden, SW; Li, L; Wurster, RD; Yan, B1
Bezprozvanny, I; Herndon, E; Huynh, DP; Liu, J; Nelson, O; Pulst, SM; Tang, TS; Tu, H1
Mahy, N; Pugliese, M; Rodríguez, MJ1
Brunet, N; Calderó, J; Esquerda, JE; Tarabal, O1
Gozen, O; Robinson, MB; Rothstein, JD; Vidensky, S; Yang, Y1
Beesen, AA; Déglon, N; Gokce, O; Kaneko, YA; Luthi-Carter, R; Régulier, E; Rudinskiy, N1
Kashihara, K; Kawada, S; Takahashi, Y1
Aldouby, Y; Domb, AJ; Kubek, MJ; Veronesi, MC1
Castillo, A; Fernández-Ruiz, J; Martinez-Orgado, J; Romero, J; Tolón, MR1
Bernardi, G; Centonze, D; Furlan, R; Martino, G; Muzio, L; Rossi, S1
Cleveland, DW; Ilieva, H; Polymenidou, M1
Deller, T; Müller, CM; Vlachos, A1
Dou, FF; Lü, HZ; Lu, PH; Ma, ZW; Wang, YX; Xu, XM; Zou, J1
Doi, Y; Jin, S; Kawanokuchi, J; Li, H; Liang, J; Mizuno, T; Noda, M; Sonobe, Y; Suzumura, A; Takeuchi, H1
Lau, A; Tymianski, M1
Andrabi, SA; Dawson, TM; Dawson, VL; Kibler, KK; Klaus, JA; Koehler, RC; Li, X; Rao, K; Xu, Z; Yang, ZJ; Zhang, J1
Bottum, K; Haley, B; Karmarkar, S; Poon, E; Tischkau, SA1
Chae, SJ; Choi, S; Choi, SK; Kang, SW; Lee, GJ; Park, E; Park, HK1
Chang, RC; Law, AC; Wuwongse, S1
Chua, BH; Chua, CC; Geng, D; Hamdy, RC; Liu, CF; Xu, X; Zhang, M1
Cantero, G; Fernández-Chacón, R; García-Junco-Clemente, P; Gómez-Sánchez, L; Linares-Clemente, P; Luján, R; Martínez-López, JA1
Botti, F; Cagnotto, A; Calcagno, E; Curti, D; De Paola, M; Diana, V; Fumagalli, E; Invernici, G; Mennini, T; Ottolina, A; Parati, E1
Battaglia, G; Bicciato, S; Bruno, V; Busceti, C; Di Marco, R; Fallarino, F; Fazio, F; Fioretti, MC; Grohmann, U; Nicoletti, F; Notartomaso, S; Puccetti, P; Vacca, C; Volpi, C1
Argyriou, AA; Giannakopoulou, F; Karanasios, P; Makridou, A; Makris, N; Vlachou, M1
Branigan, D; Chu, XP; Coombes, E; Inoue, K; Jiang, J; Seeds, J; Simon, RP; Xiong, ZG1
Bavaresco, C; de Oliveira, DL; Fischer, A; Mussulini, BH; Souza, DO; Wofchuk, S; Wyse, AT1
Agbas, A; Bao, X; Belousov, A; Choi, IY; Gerhardt, GA; Hascup, KN; Hui, D; Michaelis, EK; Pal, R; Wang, WT; Wang, X; Wang, Y1
Hasebe, S; Ogita, K; Shiba, T; Yoneyama, M1
Bernardi, G; Cavasinni, F; Centonze, D; Cravatt, BF; De Chiara, V; Furlan, R; Lutz, B; Maccarrone, M; Martino, G; Motta, C; Musella, A; Muzio, L; Rossi, S; Studer, V1
Ishii, H; Kanno, T; Sasaki, S; Sato, J; Tsuchitani, M; Wako, Y; Yamada, N1
Ao, Y; Cantle, JP; Lin, Q; Lu, XH; Mody, I; Olsen, RW; Sofroniew, MV; Sun, YE; Tao, J; Wei, W; Wu, H; Yang, XW1
Oyinbo, CA1
Deng, C; Huang, XF; Wang, Q; Wu, A; Xiong, Z; Xu, Y; Yan, J; Yang, Y; Yang, YG; Yenari, MA; Ying, W; Zhang, L; Zhu, C1
Casanovas, A; Esquerda, J; Hernández, S; Marsal, J; Martín-Satué, M; Povedano, M; Solsona, C; Texidó, L1
Kreipke, CW; Pirooz, R; Rafols, JA; Reynolds, CA; Schafer, PC; Schafer, S1
Rowland, LM1
Beller, JA; Berman, RF; Gurkoff, GG; Lyeth, BG1
Choi, JK; Das, SK; Dash, R; Emdad, L; Fisher, PB; Howlett, EL; Jeon, HY; Kang, DC; Kegelman, TP; Kim, K; Kim, SH; Lee, SG; Sarkar, D; Su, ZZ; Yoo, BK1
Campos, F; Castillo, J; Ramos-Cabrer, P; Sobrino, T1
Domin, H; Dziubina, A; Gołembiowska, K; Kajta, M; Śmiałowska, M; Zięba, B1
Angeletti, RH; Berezniuk, I; Burd, B; Fricker, LD; Ikegami, K; Lyons, PJ; Setou, M; Sironi, JJ; Vu, HT; Xiao, H1
Andersen, KM; Bak, LK; Obel, LF; Schousboe, A; Waagepetersen, HS1
Cambron, M; Clinckers, R; D'Haeseleer, M; De Keyser, J; Debruyne, J; Laureys, G1
Bickler, PE; Brosnan, H; Clark, JP; Gabatto, P; Gregersen, M; McKleroy, W; Warren, DE1
Blizzard, CA; Dickson, TC; Hosie, KA; King, AE; Vickers, JC1
Giaume, C; Orellana, JA; Sáez, JC; von Bernhardi, R1
Fujiwara, T; Kakita, A; Morimoto, K; Takahashi, H1
Kataria, H; Kaul, SC; Kaur, G; Wadhwa, R1
Foskett, JK; Kopil, CM; Neumar, RW; Siebert, AP1
Ankulu, M; Aparna, N; Khandare, AL1
Ishii, K; Mori, A; Nakahara, T; Sakamoto, K; Tsuda, Y; Ueda, K1
Sandhu, JK; Sikorska, M; Walker, PR1
Benz, AM; Hammerman, SB; Izumi, Y; Olney, JW; Shimamoto, K; Zorumski, CF1
Brambrink, AM; Guerguerian, AM; Huganir, RL; Martin, LJ; Traystman, RJ1
Aksenov, M; Aksenova, M; Booze, R; Butterfield, DA; Castegna, A; Klein, JB; Markesbery, WR; Pierce, WM; Thongboonkerd, V1
Egan, JM; Greig, NH; Haughey, NJ; Mattson, MP; Perry, T1
Lisý, V; Stastný, F1
During, MJ; Fitzsimons, HL; Kaplitt, MG; Liu, Y; Luo, J; Oshinsky, ML; Zuzga, DS1
Antonelli, T; Calzà, L; Ferraro, L; Finetti, S; Fuxe, K; Giardino, L; Soubriè, P; Tanganelli, S; Tomasini, MC1
Durham, HD; Figlewicz, DA; Kriscenski-Perry, E; Sheu, SS1
DeLorenzo, RJ; Limbrick, DD; Sombati, S1
Belmadani, A; Collins, MA; Neafsey, EJ1
Angelov, DN; Guntinas-Lichius, O; Kipnis, J; Lenzen, M; Ludolph, A; Neiss, WF; Reuter, A; Schori, H; Schwartz, M; Tomov, TL; Waibel, S; Yoles, E1
Schauwecker, PE1
Bräuer, AU; Eyüpoglu, IY; Heimrich, B; Nitsch, R; Savaskan, NE1
Angehagen, M; Ben-Menachem, E; Hansson, E; Rönnbäck, L1
Fisher, J; Mizrahi, T; Schori, H; Schwartz, M; Shaked, I1
Gruol, DL; Qiu, Z1
Friedman, LK; Kaur, J; Liu, H; Magrys, BW; Velísková, J1
Ceña, V; González-García, C; Sáez-Valero, J1
Ayala, GX; Tapia, R2
Greig, NH; Mattson, MP; Perry, T1
Chang, SF; Hu, SY; Lee, HH; Lee, YH; Wang, CC; Yang, LL1
Halaris, A; Piletz, JE; Regunathan, S; Zhu, MY1
Ramírez-Munguía, N; Tapia, R; Vera, G1
Enyu, L; Hongmin, B; Xiang, Z; Zhou, F1
Balcar, VJ; Bubeníková, V; Fitzgibbon, T; Pliss, L; Pokorný, J; St'astný, F1
Li, ST; Lu, YF; Matsui, H; Matsushita, M; Moriwaki, A; Oda, Y; Tomizawa, K; Wei, FY; Wu, HY1
Al-Semaan, Y; Densmore, M; Drost, DJ; Menon, RS; Neufeld, RW; Rajakumar, N; Schaefer, B; Théberge, J; Williamson, PC1
Heresco-Levy, U1
Alda, M; Bauer, M; Priller, J; Young, LT1
Brown, DR; Daniels, M; Sassoon, J1
Schwartz, M1
Dikranian, K; Olney, JW; Tenkova, T; Young, C1
Arundine, M; Tymianski, M1
Besson, MT; Birman, S; Iché, M; Rival, T; Soustelle, L; Strambi, C1
Cortes De Oliveira, JA; Galvis-Alonso, OY; Garcia-Cairasco, N1
Pérez-Clausell, J; Riba-Bosch, A1
Brinton, RD; Wu, TW; Zhao, L1
Batini, C; Kado, RT; Vigot, R1
Blue, ME; Buitrago, MM; Hanley, DF; Luft, AR; Thakor, NV1
Grundke-Iqbal, I; Haque, N; Iqbal, K; Li, L; Sengupta, A1
Ben-Hur, T; Grigoriadis, N; Karussis, D; Milonas, I1
Bobich, JA; Campbell, A; Zheng, Q1
Bruijn, LI; Cleveland, DW; Miller, TM1
Aronica, E; Caraci, F; Caricasole, A; Caruso, A; Copani, A; Gaviraghi, G; Nicoletti, F; Rozemuller, AJ; Storto, M; Terstappen, GC1
Dodd, PR; Hynd, MR; Scott, HL1
Avidan, H; Cardon, M; Kipnis, J; Lewitus, GM; Mordechay, S; Rolls, A; Schwartz, M; Shani, Y1
Ling, EA; Ng, YK; Zeng, XX1
Isenoumi, K; Kitaoka, Y; Kobayashi, S; Kumai, T; Kuribayashi, K; Lam, TT; Motoki, M; Munemasa, Y; Ueno, S1
Connell, BJ; Cribb, AE; Legge, C; Saleh, TM1
Molliver, ME; O'Hearn, E1
Bernal, F; Fredriksson, K; Mahy, N; Ramonet, D; Rodríguez, MJ1
Huang, Y; McNamara, JO1
Chu, XP; Hey, J; MacDonald, JF; Minami, M; Price, MP; Simon, RP; Wei, WL; Welsh, MJ; Wemmie, JA; Xiong, ZG; Zhu, XM1
Hazell, AS; Pow, DV; Yi, JH1
Barth, A; Barth, L; Newell, DW; Nguyen, LB1
Biedermann, B; Bringmann, A; Iandiev, I; Pannicke, T; Perlman, I; Reichenbach, A; Uckermann, O; Wiedemann, P1
Bantubungi, K; Blum, D; Brotchi, J; Brouillet, E; Chtarto, A; Déglon, N; Galas, MC; Greco, A; Jacquard, C; Levivier, M; Minghetti, L; Pintor, A; Popoli, P; Schiffmann, SN; Tai, K; Tenenbaum, L1
Noraberg, J1
Barger, SW; Jiang, S; Sims, TJ; Wu, SZ1
Davison, KJ; Jun, JH; Kakinohana, M; Kakinohana, O; Marsala, M; Sugahara, K1
Ashwal, S; Gross, M; Holshouser, B; Kido, D; Osterdock, R; Serna, T; Tong, K1
Cárdenas, A; Castillo, J; Dávalos, A; Fernández-Tomé, P; Hurtado, O; Leza, JC; Lizasoain, I; Lorenzo, P; Lozano, R; Moro, MA; Sánchez, V; Secades, JJ1
Bezprozvanny, I; Hayden, MR; Kristal, BS; Llinás, R; Lupu, V; Slow, E; Stavrovskaya, IG; Sugimori, M; Tang, TS1
Crews, FT; Zou, JY1
Abulrob, A; Brunette, E; Faid, K; Mealing, G; Stanimirovic, D; Tauskela, JS1
Braga, AL; Centurião, FB; Corte, CL; Emanuelli, T; Paixão, MW; Rocha, JB; Zeni, G1
Matyja, E; Nagańska, E; Rafałowska, J; Taraszewska, A1
Pourbakht, A; Sakamoto, T; Suzuki, M; Yamasoba, T1
Gyo, K; Hakuba, N; Hyodo, J; Shimizu, Y; Taniguchi, M1
Holmer, HK; Keyghobadi, M; Menashe, RA; Meshul, CK; Moore, C1
Bendel, O; Euler, Gv; Holmin, S; Mathiesen, T; Prunell, G; Stenqvist, A; Svendgaard, NA1
Del Mar, N; Deng, YP; Goldowitz, D; Lei, WL; Meade, CA; Reiner, A; Sun, Z; Wang, HB; Xie, JP1
Kress, GJ; Reynolds, IJ1
Ding, JH; Hu, G; Hu, LF; Liu, SY; Shi, XR; Sun, YH; Wang, S; Yao, HH1
Bernardino, L; Jakobsen, B; Malva, JO; Oliveira, CR; Poulsen, FR; Silva, AP; Vezzani, A; Xapelli, S; Zimmer, J1
Jellish, WS; Kindel, G; Murdoch, J; White, FA; Zhang, X1
Dineley, KE; Reynolds, IJ; Richards, LL; Votyakova, TV1
Domercq, M; Matute, C; Pérez-Cerdá, F; Ravid, R; Vallejo-Illarramendi, A1
Ribeiro, JA1
Halliwell, B; Hyun, DH; Jenner, P; Lee, M1
Arakawa, M; Ishige, K; Ito, Y; Saito, H; Tanaka, M1
Almeida, A; Bolaños, JP; Delgado-Esteban, M; Diaz-Hernandez, JI; Fernandez, E1
Busto, R; Dave, KR; Lange-Asschenfeldt, C; Pérez-Pinzón, MA; Prado, R; Raval, AP; Saul, I1
Horák, M; Petrović, M; Sedlácek, M; Vyklický, L1
Hazell, AS; Hoover, R; McIntosh, TK; Yi, JH1
Hachiya, Y; Hayashi, M; Kumada, S; Kurata, K; Tsuchiya, K; Uchiyama, A1
Carrier, RL; Hoyt, KR; Ma, TC; Obrietan, K1
Añez, Y; Coutin-Churchman, P; Moreno, R; Vergara, F1
Chan, SL; Kim, SJ; Lee, J; Mattson, MP; Son, TG1
Kanazawa, Y; Makino, M; Morishima, Y; Shirasaki, Y1
Cheret, C; Colin, C; Gervais, A; Hinners, I; Mallat, M; Qin, S1
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Fischer, KM1
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Cha, JH; Kosinski, CM; Schwarz, M; Young, AB1
Brustovetsky, N; Dubinsky, JM1
Bernal, F; Forni, C; Kerkerian-Le Goff, L; Lievens, JC; Mahy, N1
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Hill, IE; MacManus, JP; Murray, C; Rasquinha, I; Richard, J1
Meldrum, BS1
Sharp, FR; Tolliver, BK; Tomitaka, M; Tomitaka, S1
Allen, C; Meshul, CK1
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Hopkins, KJ; Schmued, LC; Wang, G1
Ludolph, AC; Meyer, T; Riepe, MW1
Eggett, CJ; Shaw, PJ1
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Chan, SL; Glazner, GW; Lu, C; Mattson, MP1
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Battaglia, G; Bruno, V; Catania, MV; Flor, PJ; Gasparini, F; Giuffrida, R; Hampson, DR; Inderbitzin, W; Ksiazek, I; Kuhn, R; Leonhardt, T; Lukic, S; Nicoletti, F; van der Putten, H1
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Favalli, L; Govoni, S; Lanza, E; Masoero, E; Montalbetti, L; Rizzo, V; Rozza, A1
Kirino, T1
Lovell, MA; Markesbery, WR; Xie, C1
Matyja, E1
Babcock, DJ; Choi, DW; Lee, JM; Zipfel, GJ1
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Chen, CJ; Liao, SL1
Ferger, B; Schmidt, N1
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Koinig, H; Rueda, C; Vornik, V; Zornow, MH1
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Ghetti, B; McBride, WJ1

Reviews

79 review(s) available for glutamic acid and Nerve Degeneration

ArticleYear
Nitric Oxide Signaling in Neurodegeneration and Cell Death.
    Advances in pharmacology (San Diego, Calif.), 2018, Volume: 82

    Topics: Animals; Cell Death; Glutamic Acid; Humans; Nerve Degeneration; Nitric Oxide; Nitric Oxide Synthase Type I; Signal Transduction

2018
Sports-Related Concussion: Neurometabolic Aspects.
    Seminars in speech and language, 2019, Volume: 40, Issue:5

    Topics: Athletic Injuries; Biomarkers; Brain; Brain Concussion; Brain Damage, Chronic; Calcium; Chronic Traumatic Encephalopathy; Energy Metabolism; Glutamic Acid; Humans; Macrophage Activation; Membrane Potentials; Nerve Degeneration; Neurons; Potassium; Regional Blood Flow; Return to Sport

2019
Pathophysiology of neurodegeneration following traumatic brain injury.
    The West Indian medical journal, 2012, Volume: 61, Issue:7

    Topics: Brain Injuries; Cell Death; Excitatory Amino Acids; Glutamic Acid; Humans; Inflammation; Nerve Degeneration; Oxidative Stress

2012
No longer falling on deaf ears: mechanisms of degeneration and regeneration of cochlear ribbon synapses.
    Hearing research, 2015, Volume: 329

    Topics: Animals; Cochlea; Deafness; Glutamic Acid; Hair Cells, Auditory; Hearing; Hearing Loss, Noise-Induced; Humans; Nerve Degeneration; Nerve Regeneration; Presbycusis; Spiral Ganglion; Synapses; Synaptic Transmission

2015
The Chemistry of Neurodegeneration: Kinetic Data and Their Implications.
    Molecular neurobiology, 2016, Volume: 53, Issue:5

    Topics: Animals; Free Radicals; Glutamic Acid; Humans; Inflammation; Kinetics; Nerve Degeneration; Polyamines

2016
Excitotoxicity in ALS: Overstimulation, or overreaction?
    Experimental neurology, 2016, Volume: 275 Pt 1

    Topics: Amyotrophic Lateral Sclerosis; Cell Death; Glutamic Acid; Humans; Motor Neurons; Nerve Degeneration; Spinal Cord

2016
Cochlear synaptopathy in acquired sensorineural hearing loss: Manifestations and mechanisms.
    Hearing research, 2017, Volume: 349

    Topics: Animals; Auditory Perception; Auditory Threshold; Cochlear Nerve; Glutamic Acid; Hair Cells, Auditory, Inner; Hearing; Hearing Loss, Noise-Induced; Hearing Loss, Sensorineural; Humans; Nerve Degeneration; Noise; Risk Factors; Synapses; Synaptic Transmission

2017
Grey matter pathology in multiple sclerosis.
    The Lancet. Neurology, 2008, Volume: 7, Issue:9

    Topics: Cerebral Cortex; Encephalitis; Glutamic Acid; Humans; Intercellular Signaling Peptides and Proteins; Meninges; Mitochondria; Multiple Sclerosis; Nerve Degeneration; Neurons

2008
Pathophysiology of neurodegeneration in familial amyotrophic lateral sclerosis.
    Current molecular medicine, 2009, Volume: 9, Issue:3

    Topics: Amyotrophic Lateral Sclerosis; Animals; Ciliary Neurotrophic Factor; Glutamic Acid; Humans; Intermediate Filament Proteins; Membrane Glycoproteins; Mitochondria; Motor Neurons; Mutation; Nerve Degeneration; Nerve Tissue Proteins; Neurofilament Proteins; Peripherins; Ribonuclease, Pancreatic; Sodium-Potassium-Exchanging ATPase; Superoxide Dismutase; Superoxide Dismutase-1; Survival of Motor Neuron 1 Protein; Vascular Endothelial Growth Factor A

2009
Drug abuse, brain calcification and glutamate-induced neurodegeneration.
    Current drug abuse reviews, 2009, Volume: 2, Issue:1

    Topics: Adaptation, Physiological; Animals; Brain; Calcinosis; Calcium; Glutamic Acid; Humans; Nerve Degeneration; Receptors, Glutamate; Reinforcement, Psychology; Substance-Related Disorders

2009
The link between inflammation, synaptic transmission and neurodegeneration in multiple sclerosis.
    Cell death and differentiation, 2010, Volume: 17, Issue:7

    Topics: Animals; Cytokines; Demyelinating Diseases; Encephalomyelitis, Autoimmune, Experimental; Glutamic Acid; Inflammation; Multiple Sclerosis; Nerve Degeneration; Synaptic Transmission

2010
Non-cell autonomous toxicity in neurodegenerative disorders: ALS and beyond.
    The Journal of cell biology, 2009, Dec-14, Volume: 187, Issue:6

    Topics: Amyotrophic Lateral Sclerosis; Animals; Astrocytes; Axonal Transport; Capillaries; Cell Death; Endoplasmic Reticulum; Glutamic Acid; Humans; Microglia; Mutation; Nerve Degeneration; Neurons; Stress, Physiological; Superoxide Dismutase; Superoxide Dismutase-1; Superoxides; T-Lymphocytes

2009
Glutamate receptors, neurotoxicity and neurodegeneration.
    Pflugers Archiv : European journal of physiology, 2010, Volume: 460, Issue:2

    Topics: Animals; Antioxidants; Calcium; Calpain; Caspases; Cell Death; Free Radical Scavengers; Free Radicals; Glutamic Acid; Humans; Hypothalamus; Nerve Degeneration; Neurodegenerative Diseases; Neurotoxicity Syndromes; Nitric Oxide; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Sodium-Calcium Exchanger; Zinc

2010
The putative neurodegenerative links between depression and Alzheimer's disease.
    Progress in neurobiology, 2010, Volume: 91, Issue:4

    Topics: Acetylcholine; Alzheimer Disease; Animals; Depression; Glutamic Acid; Humans; Nerve Degeneration; Neurons

2010
Adult neurogenesis is regulated by endogenous factors produced during neurodegeneration.
    Journal of pharmacological sciences, 2011, Volume: 115, Issue:4

    Topics: Animals; Biomarkers; Brain; Brain Injuries; Cytokines; Glutamic Acid; Humans; Nerve Degeneration; Neurodegenerative Diseases; Neurogenesis; Reactive Oxygen Species; Stroke

2011
Secondary injury mechanisms in traumatic spinal cord injury: a nugget of this multiply cascade.
    Acta neurobiologiae experimentalis, 2011, Volume: 71, Issue:2

    Topics: Apoptosis; Calcium; Disease Progression; Glutamic Acid; Humans; Immune System Diseases; Lipid Peroxidation; Nerve Degeneration; Nervous System Diseases; Neuroprotective Agents; Spinal Cord Injuries; Tumor Necrosis Factor-alpha

2011
Oxaloacetate: a novel neuroprotective for acute ischemic stroke.
    The international journal of biochemistry & cell biology, 2012, Volume: 44, Issue:2

    Topics: Animals; Brain; Brain Ischemia; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Nerve Degeneration; Neuroprotective Agents; Oxaloacetic Acid; Stroke

2012
White-matter astrocytes, axonal energy metabolism, and axonal degeneration in multiple sclerosis.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2012, Volume: 32, Issue:3

    Topics: Astrocytes; Axons; Brain; Energy Metabolism; Glutamic Acid; Humans; Mitochondria; Multiple Sclerosis; Nerve Degeneration; Phosphocreatine

2012
Glial hemichannels and their involvement in aging and neurodegenerative diseases.
    Reviews in the neurosciences, 2012, Jan-26, Volume: 23, Issue:2

    Topics: Adenosine Triphosphate; Aging; Astrocytes; Calcium; Cannabinoids; Central Nervous System; Connexin 43; Connexins; Dinoprostone; Glucose; Glutamic Acid; Humans; Inflammation; Interleukin-1beta; Ion Channels; NAD; Nerve Degeneration; Nerve Tissue Proteins; Neurodegenerative Diseases; Neurons; Oligodendroglia; Signal Transduction; Tumor Necrosis Factor-alpha

2012
Role of glutamate and nitric oxide in onset of motor neuron degeneration in neurolathyrism.
    Neurotoxicology, 2013, Volume: 34

    Topics: Animals; Estrogens; Glutamate-Cysteine Ligase; Glutamic Acid; Humans; Lathyrism; Mitochondria; Motor Cortex; Motor Neuron Disease; Motor Neurons; Nerve Degeneration; Nitric Oxide; Vascular Endothelial Growth Factor A

2013
Protective autoimmunity against the enemy within: fighting glutamate toxicity.
    Trends in neurosciences, 2003, Volume: 26, Issue:6

    Topics: Animals; Autoimmunity; Central Nervous System; Glutamic Acid; Immune Tolerance; Inflammation; Mice; Nerve Degeneration; Neurodegenerative Diseases; Rats; T-Lymphocytes; Vaccines

2003
Glutamatergic neurotransmission modulation and the mechanisms of antipsychotic atypicality.
    Progress in neuro-psychopharmacology & biological psychiatry, 2003, Volume: 27, Issue:7

    Topics: Animals; Antipsychotic Agents; Aspartic Acid; Glutamic Acid; Glycine; Humans; Nerve Degeneration; Neurotoxins; Psychotic Disorders; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Synaptic Transmission

2003
Implications of the neuroprotective effects of lithium for the treatment of bipolar and neurodegenerative disorders.
    Pharmacopsychiatry, 2003, Volume: 36 Suppl 3

    Topics: Alzheimer Disease; Bipolar Disorder; Glucocorticoids; Glutamic Acid; Humans; Huntington Disease; Lithium Compounds; Nerve Degeneration; Neurodegenerative Diseases; Neuroprotective Agents; Signal Transduction

2003
Protective autoimmunity and prospects for therapeutic vaccination against self-perpetuating neurodegeneration.
    Ernst Schering Research Foundation workshop, 2004, Issue:47

    Topics: Animals; Autoimmunity; Cell Death; Epitopes; Glutamic Acid; Humans; Nerve Degeneration; Neurons; Vaccination

2004
Excitotoxic versus apoptotic mechanisms of neuronal cell death in perinatal hypoxia/ischemia.
    Current molecular medicine, 2004, Volume: 4, Issue:2

    Topics: Animals; Animals, Newborn; Apoptosis; Brain; Cell Death; Central Nervous System; Glutamic Acid; Hypoxia; Hypoxia-Ischemia, Brain; Immunohistochemistry; Ischemia; Microscopy, Electron; Nerve Degeneration; Neurons; Rats; Silver Staining; Synapses; Time Factors

2004
Molecular mechanisms of glutamate-dependent neurodegeneration in ischemia and traumatic brain injury.
    Cellular and molecular life sciences : CMLS, 2004, Volume: 61, Issue:6

    Topics: Animals; Brain Injuries; Brain Ischemia; Glutamic Acid; Humans; N-Methylaspartate; Nerve Degeneration; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate

2004
Axonal damage in multiple sclerosis: a complex issue in a complex disease.
    Clinical neurology and neurosurgery, 2004, Volume: 106, Issue:3

    Topics: Adjuvants, Immunologic; Axons; Brain; Demyelinating Diseases; Diagnosis, Differential; Glutamic Acid; Humans; Interferon-beta; Macrophages; Magnetic Resonance Imaging; Multiple Sclerosis; Myelin Sheath; Nerve Degeneration

2004
Unraveling the mechanisms involved in motor neuron degeneration in ALS.
    Annual review of neuroscience, 2004, Volume: 27

    Topics: Amyotrophic Lateral Sclerosis; Animals; Dyneins; Glutamic Acid; Humans; Models, Neurological; Motor Neurons; Nerve Degeneration; Neurofilament Proteins; Superoxide Dismutase; Vascular Endothelial Growth Factor A

2004
Glutamate-mediated excitotoxicity and neurodegeneration in Alzheimer's disease.
    Neurochemistry international, 2004, Volume: 45, Issue:5

    Topics: Alzheimer Disease; Animals; Biogenic Polyamines; Excitatory Amino Acids; Glutamic Acid; Humans; Nerve Degeneration; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission

2004
Ischemic stroke: "acidotoxicity" is a perpetrator.
    Cell, 2004, Sep-17, Volume: 118, Issue:6

    Topics: Acidosis; Animals; Brain Ischemia; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Nerve Degeneration; Neuroprotective Agents; Receptors, Glutamate; Stroke

2004
What can adenosine neuromodulation do for neuroprotection?
    Current drug targets. CNS and neurological disorders, 2005, Volume: 4, Issue:4

    Topics: Adenosine; Animals; Brain Damage, Chronic; Brain-Derived Neurotrophic Factor; Cell Survival; Glutamic Acid; Humans; Hypoxia; Nerve Degeneration; Neurons; Neuroprotective Agents; Reactive Oxygen Species; Receptors, Purinergic P1

2005
Physiology and pathology of NMDA receptors.
    Prague medical report, 2005, Volume: 106, Issue:2

    Topics: Animals; Brain; Glutamic Acid; Glycine; Humans; Ion Channels; Nerve Degeneration; Oxidation-Reduction; Receptors, N-Methyl-D-Aspartate

2005
Excitotoxicity and amyotrophic lateral sclerosis.
    Neuro-degenerative diseases, 2005, Volume: 2, Issue:3-4

    Topics: Amyotrophic Lateral Sclerosis; Animals; Calcium; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Motor Neurons; Nerve Degeneration; Receptors, Glutamate

2005
Molecular targets in cerebral ischemia for developing novel therapeutics.
    Brain research reviews, 2007, Volume: 54, Issue:1

    Topics: Animals; Brain Ischemia; Calcium Signaling; Cell Communication; Cell Death; Cerebral Cortex; Glutamic Acid; Humans; Nerve Degeneration; Oxidative Stress; Signal Transduction

2007
[Spinal cord protection and opioids].
    Masui. The Japanese journal of anesthesiology, 2007, Volume: 56, Issue:3

    Topics: Analgesics, Opioid; Animals; Anterior Horn Cells; Dose-Response Relationship, Drug; Fentanyl; Glutamic Acid; Humans; Morphine; Naloxone; Nerve Degeneration; Paraparesis, Spastic; Rats; Receptors, N-Methyl-D-Aspartate; Spinal Cord Ischemia; Thoracic Surgical Procedures

2007
Matrix metalloproteinase-9 in glutamate-dependent adult brain function and dysfunction.
    Cell death and differentiation, 2007, Volume: 14, Issue:7

    Topics: Animals; Brain; Brain Infarction; Cell Membrane; Glutamic Acid; Humans; Matrix Metalloproteinase 9; Nerve Degeneration; Neuronal Plasticity; Neurotoxins; Protein Transport

2007
Role of K(ATP) channels in protection against neuronal excitatory insults.
    Journal of neurochemistry, 2007, Volume: 103, Issue:5

    Topics: Animals; Glutamic Acid; Ion Channel Gating; Models, Biological; Nerve Degeneration; Neurons; Potassium Channels, Inwardly Rectifying; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission

2007
Vascular dementia: pharmacological treatment approaches and perspectives.
    Clinical interventions in aging, 2007, Volume: 2, Issue:3

    Topics: Brain Ischemia; Cholinesterase Inhibitors; Cognition; Dementia, Vascular; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Nerve Degeneration; Neuroprotective Agents; Nootropic Agents; Receptors, Glutamate; Treatment Outcome

2007
Cholinergic and other neurotransmitter mechanisms in Parkinson's disease, Parkinson's disease dementia, and dementia with Lewy bodies.
    Movement disorders : official journal of the Movement Disorder Society, 2007, Volume: 22 Suppl 17

    Topics: Acetylcholine; Atrophy; Cerebral Cortex; Cholinergic Fibers; Dementia; Glutamic Acid; Humans; Lewy Body Disease; Nerve Degeneration; Parkinson Disease; Receptors, Nicotinic; Serotonin; Synaptic Transmission

2007
Recent advances in the use of selective neuron-destroying agents for neurobiological research.
    Experientia, 1984, Jun-15, Volume: 40, Issue:6

    Topics: Animals; Aziridines; Choline; Colchicine; Folic Acid; Glutamates; Glutamic Acid; Ibotenic Acid; Kainic Acid; Lectins; Mitogens; Mustard Compounds; Nerve Degeneration; Nervous System; Neurons; Piperidines; Pyrrolidonecarboxylic Acid; Quinolinic Acid; Quinolinic Acids

1984
Adenosine: a prototherapeutic concept in neurodegeneration.
    Annals of the New York Academy of Sciences, 1995, Sep-15, Volume: 765

    Topics: Adenosine; Animals; Brain; Brain Diseases; Glutamic Acid; Humans; Nerve Degeneration; Neuroprotective Agents; Receptors, Purinergic P1; Stress, Physiological

1995
Triggering and execution of neuronal death in brain ischaemia: two phases of glutamate release by different mechanisms.
    Trends in neurosciences, 1994, Volume: 17, Issue:9

    Topics: Animals; Brain Ischemia; Cell Death; Glutamic Acid; Humans; Nerve Degeneration; Neurons; Receptors, N-Methyl-D-Aspartate

1994
Molecular approaches to amyotrophic lateral sclerosis.
    Annual review of medicine, 1995, Volume: 46

    Topics: Amyotrophic Lateral Sclerosis; Autoimmune Diseases; Free Radicals; Glutamic Acid; Humans; Isoenzymes; Motor Neurons; Mutation; Nerve Degeneration; Phenotype; Superoxide Dismutase; Survival Rate

1995
Reactions of nitric oxide, superoxide and peroxynitrite with superoxide dismutase in neurodegeneration.
    Progress in brain research, 1994, Volume: 103

    Topics: Amyotrophic Lateral Sclerosis; Animals; Brain Ischemia; Cattle; Glutamic Acid; Humans; Macrophages; Models, Neurological; Molecular Structure; Motor Neurons; Myocardial Ischemia; Nerve Degeneration; Nerve Tissue Proteins; Nitrates; Nitric Oxide; Peripheral Nerve Injuries; Peripheral Nerves; Superoxide Dismutase; Superoxides

1994
Glutamate, beta-amyloid precursor proteins, and calcium mediated neurofibrillary degeneration.
    Journal of neural transmission. Supplementum, 1994, Volume: 44

    Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Calcium; Chromosomes, Human, Pair 14; Chromosomes, Human, Pair 19; Chromosomes, Human, Pair 21; Glutamic Acid; Humans; Models, Neurological; Mutation; Nerve Degeneration; Neurofibrillary Tangles; Rats

1994
Melatonin, hydroxyl radical-mediated oxidative damage, and aging: a hypothesis.
    Journal of pineal research, 1993, Volume: 14, Issue:4

    Topics: Aging; Animals; Calcium; Free Radical Scavengers; Free Radicals; Glutamates; Glutamic Acid; Humans; Hydroxides; Melatonin; Nerve Degeneration

1993
Origins of glutamate release in ischaemia.
    Acta neurochirurgica. Supplement, 1996, Volume: 66

    Topics: Adenosine Triphosphate; Amino Acid Transport System X-AG; Animals; ATP-Binding Cassette Transporters; Brain Damage, Chronic; Brain Ischemia; Cortical Spreading Depression; Disease Models, Animal; Exocytosis; Glutamic Acid; Humans; Membrane Potentials; Microdialysis; Nerve Degeneration; Rats; Receptors, N-Methyl-D-Aspartate; Signal Processing, Computer-Assisted

1996
Excitotoxicity and neurodegenerative diseases.
    Current opinion in neurology, 1995, Volume: 8, Issue:6

    Topics: Animals; Apoptosis; Brain Ischemia; Disease Models, Animal; Glutamic Acid; Nerve Degeneration; Nervous System Diseases

1995
Hippocampal degeneration inducing impairment of learning in rats: model of dementia?
    Behavioural brain research, 1997, Volume: 83, Issue:1-2

    Topics: Animals; Dementia; Glutamic Acid; Hippocampus; Learning Disabilities; Nerve Degeneration; Rats; Trimethyltin Compounds

1997
Delayed neuronal degeneration results from endogenous glutamate excess. Possible role in NP-SLE.
    Annals of the New York Academy of Sciences, 1997, Aug-14, Volume: 823

    Topics: Animals; Glutamic Acid; Humans; Lupus Erythematosus, Systemic; Mental Disorders; Nerve Degeneration; Nervous System Diseases; Time Factors

1997
Changes in astrocytic glutamate catabolism enzymes following neuronal degeneration or viral infection.
    Glia, 1997, Volume: 21, Issue:1

    Topics: Animals; Astrocytes; Brain; Central Nervous System Diseases; Glutamate Dehydrogenase; Glutamate-Ammonia Ligase; Glutamic Acid; Hippocampus; HTLV-I Infections; Humans; Nerve Degeneration; Neurons; Rats; Serotonin

1997
Excitotoxic mechanisms of neurodegeneration in transmissible spongiform encephalopathies.
    Annals of the New York Academy of Sciences, 1997, Oct-15, Volume: 825

    Topics: Animals; Brain; Cricetinae; Glutamic Acid; Humans; Hypothalamus; Ibogaine; Kainic Acid; Mice; N-Methylaspartate; Nerve Degeneration; Neurotoxins; Prion Diseases

1997
Release and uptake of glutamate as related to excitotoxicity.
    Revista brasileira de biologia, 1996, Volume: 56 Su 1 Pt 1

    Topics: 4-Aminopyridine; Cell Culture Techniques; Glutamic Acid; N-Methylaspartate; Nerve Degeneration

1996
Pharmacotherapy of cerebral ischemia in cocaine dependence.
    Drug and alcohol dependence, 1998, Jan-01, Volume: 49, Issue:2

    Topics: Aspirin; Brain; Brain Ischemia; Cerebrovascular Circulation; Cocaine; Cocaine-Related Disorders; Cognition Disorders; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Humans; Intracranial Embolism and Thrombosis; Male; Nerve Degeneration; Neuropsychological Tests; Platelet Aggregation Inhibitors; Radionuclide Imaging; Substance Withdrawal Syndrome

1998
Glutamic acid and Alzheimer's disease.
    Neurobiology (Budapest, Hungary), 1998, Volume: 6, Issue:1

    Topics: Alzheimer Disease; Glutamic Acid; Humans; Nerve Degeneration; Neurons; Synaptic Transmission

1998
Neural disease: Drosophila degenerates for a good cause.
    Current biology : CB, 1998, Nov-05, Volume: 8, Issue:22

    Topics: Animals; Drosophila; Genes, Insect; Glutamic Acid; Humans; Microsatellite Repeats; Mutation; Nerve Degeneration

1998
Neurodegeneration and glutamate induced oxidative stress.
    Progress in brain research, 1998, Volume: 116

    Topics: Animals; Brain; Brain Diseases; Glutamic Acid; Humans; Nerve Degeneration; Oxidative Stress

1998
Glutamate toxicity in chronic neurodegenerative disease.
    Progress in brain research, 1998, Volume: 116

    Topics: Animals; Chronic Disease; Glutamic Acid; Humans; Nerve Degeneration; Neurotoxins

1998
On the relationship between extracellular glutamate, hyperexcitation and neurodegeneration, in vivo.
    Neurochemistry international, 1999, Volume: 34, Issue:1

    Topics: Animals; Cell Death; Excitatory Amino Acids; Extracellular Space; Glutamic Acid; Humans; Nerve Degeneration; Nervous System Diseases; Neurons

1999
Motor neurone disease.
    BMJ (Clinical research ed.), 1999, Apr-24, Volume: 318, Issue:7191

    Topics: Clinical Trials as Topic; Glutamic Acid; Humans; Motor Neuron Disease; Nerve Degeneration; Oxidative Stress

1999
Group-I metabotropic glutamate receptors: hypotheses to explain their dual role in neurotoxicity and neuroprotection.
    Neuropharmacology, 1999, Volume: 38, Issue:10

    Topics: Animals; Astrocytes; Glutamic Acid; Humans; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Receptors, Metabotropic Glutamate

1999
[Huntington chorea. Animal models reveal new hypotheses for pathophysiology and therapy].
    Der Nervenarzt, 1999, Volume: 70, Issue:10

    Topics: Animals; Brain; Cell Death; Disease Models, Animal; Glutamic Acid; Humans; Huntington Disease; Mice; Mice, Transgenic; Models, Genetic; Nerve Degeneration; Receptors, Metabotropic Glutamate; Trinucleotide Repeats

1999
Glutamate as a neurotransmitter in the brain: review of physiology and pathology.
    The Journal of nutrition, 2000, Volume: 130, Issue:4S Suppl

    Topics: Animals; Brain; Glutamic Acid; Humans; Nerve Degeneration; Nervous System Diseases; Neurotransmitter Agents; Reference Values

2000
The role of excitotoxicity in ALS--what is the evidence?
    Journal of neurology, 2000, Volume: 247 Suppl 1

    Topics: Amyotrophic Lateral Sclerosis; Animals; Disease Models, Animal; Glutamic Acid; Humans; Hypoxia; Motor Neurons; Nerve Degeneration; Neurotoxins; Superoxide Dismutase; Superoxide Dismutase-1

2000
Molecular factors underlying selective vulnerability of motor neurons to neurodegeneration in amyotrophic lateral sclerosis.
    Journal of neurology, 2000, Volume: 247 Suppl 1

    Topics: Amyotrophic Lateral Sclerosis; Calcium-Binding Proteins; Cytoskeleton; Glutamic Acid; Humans; Mitochondria; Motor Neurons; Nerve Degeneration; Point Mutation; Receptors, Glutamate; Superoxide Dismutase; Superoxide Dismutase-1

2000
Neuroprotection by glutamine synthetase.
    The Israel Medical Association journal : IMAJ, 2000, Volume: 2 Suppl

    Topics: Animals; Gene Expression Regulation, Enzymologic; Glutamate-Ammonia Ligase; Glutamic Acid; Glutamine; Humans; Nerve Degeneration; Neuroglia; Neuroprotective Agents; Proto-Oncogene Proteins c-jun; Receptors, Glucocorticoid; Retina

2000
Delayed neuronal death.
    Neuropathology : official journal of the Japanese Society of Neuropathology, 2000, Volume: 20 Suppl

    Topics: Animals; Brain Ischemia; Calcium; Cell Death; Glutamic Acid; Hippocampus; Humans; Nerve Degeneration; Neurotoxins; Pyramidal Cells; Time Factors

2000
Neuronal apoptosis after CNS injury: the roles of glutamate and calcium.
    Journal of neurotrauma, 2000, Volume: 17, Issue:10

    Topics: Animals; Apoptosis; Brain Injuries; Brain Ischemia; Calcium; Calcium Signaling; Glutamic Acid; Humans; Necrosis; Nerve Degeneration; Neuroprotective Agents; Neurotoxins

2000
Factors directly affecting impulse transmission in inflammatory demyelinating disease: recent advances in our understanding.
    Current opinion in neurology, 2001, Volume: 14, Issue:3

    Topics: Autoantibodies; Axons; Blood-Brain Barrier; Brain; Cytokines; Glutamic Acid; Guillain-Barre Syndrome; Humans; Membrane Potentials; Multiple Sclerosis; Nerve Degeneration; Nitric Oxide; Synaptic Transmission

2001
Neurobiology of hypoxic-ischemic injury in the developing brain.
    Pediatric research, 2001, Volume: 49, Issue:6

    Topics: Animals; Apoptosis; Brain; Brain Injuries; Brain Ischemia; Cerebral Palsy; Fetal Hypoxia; Glucose; Glutamic Acid; Humans; Hypoxia, Brain; Mitochondria; Nerve Degeneration

2001
Mechanisms of neurodegeneration in amyotrophic lateral sclerosis.
    Molecular pathology : MP, 2001, Volume: 54, Issue:6

    Topics: Aged; Amyotrophic Lateral Sclerosis; Animals; Copper; Cytoplasm; Glutamic Acid; Humans; Mice; Mice, Transgenic; Middle Aged; Mitochondria; Models, Animal; Mutation; Nerve Degeneration; Neurofilament Proteins; Neurons; Oxidative Stress; Superoxide Dismutase; Superoxide Dismutase-1

2001
Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?
    Annals of neurology, 1992, Volume: 31, Issue:2

    Topics: Aging; Alzheimer Disease; Animals; Brain Diseases; Cell Death; Energy Metabolism; Glutamates; Glutamic Acid; Humans; Huntington Disease; Ion Channel Gating; Mitochondria; Models, Biological; MPTP Poisoning; Nerve Degeneration; Neurons; Neurotoxins; Oxidative Phosphorylation; Parkinson Disease; Parkinson Disease, Secondary; Primates; Rats; Receptors, N-Methyl-D-Aspartate

1992
Regulatory role of astrocytes for neuronal biosynthesis and homeostasis of glutamate and GABA.
    Progress in brain research, 1992, Volume: 94

    Topics: Alanine; Amino Acids; Animals; Astrocytes; Brain; Cell Communication; Epilepsy; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Homeostasis; Humans; Nerve Degeneration; Neurons

1992
Altered glutamatergic mechanisms and selective motor neuron degeneration in amyotrophic lateral sclerosis: possible role of glycine.
    Advances in neurology, 1991, Volume: 56

    Topics: Amyotrophic Lateral Sclerosis; Animals; Glutamates; Glutamic Acid; Glutamine; Glycine; Humans; Motor Neurons; Nerve Degeneration; Synaptic Transmission

1991
The use of astrocytes in culture as model systems for evaluating neurotoxic-induced-injury.
    Neurotoxicology, 1991,Fall, Volume: 12, Issue:3

    Topics: Ammonia; Animals; Astrocytes; Cells, Cultured; Glutamates; Glutamic Acid; Huntington Disease; Metals; Models, Neurological; MPTP Poisoning; Nerve Degeneration; Nervous System

1991
Quinolinic acid and kynurenic acid in the mammalian brain.
    Advances in experimental medicine and biology, 1991, Volume: 294

    Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; AIDS Dementia Complex; Animals; Aspartic Acid; Biological Transport; Brain Chemistry; Brain Diseases; Dioxygenases; Epilepsy, Temporal Lobe; Glutamates; Glutamic Acid; Humans; Kynurenic Acid; Kynurenine; Lyases; Nerve Degeneration; Oxygenases; Quinolinic Acid; Quinolinic Acids; Rats; Receptors, Neurotransmitter; Transaminases

1991
Glutamate receptor antagonism: neurotoxicity, anti-akinetic effects, and psychosis.
    Journal of neural transmission. Supplementum, 1991, Volume: 34

    Topics: Animals; Glutamates; Glutamic Acid; Humans; Models, Neurological; Models, Psychological; Nerve Degeneration; Neurons; Neurotoxins; Psychotic Disorders; Receptors, Glutamate; Receptors, Neurotransmitter; Schizophrenia

1991
Glutamate in the mammalian CNS.
    European archives of psychiatry and clinical neuroscience, 1990, Volume: 240, Issue:2

    Topics: Animals; Behavior, Animal; Brain; Glutamates; Glutamic Acid; Humans; Nerve Degeneration; Neurocognitive Disorders; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synaptic Transmission

1990
Possible therapeutic applications of antagonists of excitatory amino acid neurotransmitters.
    Clinical science (London, England : 1979), 1985, Volume: 68, Issue:2

    Topics: Alzheimer Disease; Animals; Aspartic Acid; Basal Ganglia Diseases; Brain; Brain Ischemia; Epilepsy; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Humans; Huntington Disease; Mice; Movement Disorders; Nerve Degeneration; Neurotransmitter Agents; Parkinson Disease; Rats

1985

Other Studies

437 other study(ies) available for glutamic acid and Nerve Degeneration

ArticleYear
Coactivation of GSK3β and IGF-1 Attenuates Amyotrophic Lateral Sclerosis Nerve Fiber Cytopathies in SOD1 Mutant Patient-Derived Motor Neurons.
    Cells, 2021, 10-16, Volume: 10, Issue:10

    Topics: Amyotrophic Lateral Sclerosis; Animals; Axons; Benzyl Alcohols; Calcium; Cell Differentiation; Glucosides; Glutamic Acid; Glycogen Synthase Kinase 3 beta; Humans; Induced Pluripotent Stem Cells; Insulin-Like Growth Factor I; MAP Kinase Signaling System; Mice, Transgenic; Motor Neurons; Mutation; Nerve Degeneration; Nerve Fibers; Neurites; Superoxide Dismutase-1; Survival Analysis

2021
MicroRNA-223 protects neurons from degeneration in experimental autoimmune encephalomyelitis.
    Brain : a journal of neurology, 2019, 10-01, Volume: 142, Issue:10

    Topics: Animals; Axons; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Glutamic Acid; Humans; Leukocytes, Mononuclear; Mice; MicroRNAs; Multiple Sclerosis; Nerve Degeneration; Neurodegenerative Diseases; Neurons; Rats; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction; Spinal Cord

2019
Astrocyte senescence promotes glutamate toxicity in cortical neurons.
    PloS one, 2020, Volume: 15, Issue:1

    Topics: Alzheimer Disease; Amino Acid Transport System X-AG; Astrocytes; Brain; Cell Cycle Checkpoints; Cellular Senescence; Gene Expression Regulation; Glutamic Acid; Humans; Nerve Degeneration; Neurons; Primary Cell Culture; X-Rays

2020
Mutation of NEKL-4/NEK10 and TTLL genes suppress neuronal ciliary degeneration caused by loss of CCPP-1 deglutamylase function.
    PLoS genetics, 2020, Volume: 16, Issue:10

    Topics: Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Carboxypeptidases; Carrier Proteins; Cilia; Glutamic Acid; Humans; Kinesins; Microtubules; Mutation; Nerve Degeneration; Neurons; NIMA-Related Kinases; Peptide Synthases; Protein Processing, Post-Translational; Tubulin

2020
Live Animal Imaging and Cell Sorting Methods for Investigating Neurodegeneration in a C. elegans Excitotoxic Necrosis Model.
    Journal of visualized experiments : JoVE, 2021, 01-22, Issue:167

    Topics: Aging; Animal Husbandry; Animals; Apoptosis; Buffers; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Disease Models, Animal; Flow Cytometry; Glutamic Acid; Imaging, Three-Dimensional; Mitochondria; Necrosis; Nerve Degeneration; Neurons; Neuroprotection; Neurotoxins; Risk Factors; RNA; Transcriptome

2021
GLT1 gene delivery based on bone marrow-derived cells ameliorates motor function and survival in a mouse model of ALS.
    Scientific reports, 2021, 06-17, Volume: 11, Issue:1

    Topics: Amyotrophic Lateral Sclerosis; Animals; Biomarkers; Bone Marrow Cells; Bone Marrow Transplantation; Cell Survival; Cytokines; Disease Models, Animal; Disease Progression; Excitatory Amino Acid Transporter 2; Gene Expression Regulation; Gene Transfer Techniques; Genetic Therapy; Gliosis; Glutamic Acid; Lentivirus; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Motor Activity; Motor Neurons; Muscular Atrophy; Nerve Degeneration; RNA, Messenger; Spinal Cord; Superoxide Dismutase-1; Survival Analysis

2021
Suppression of SNARE-dependent exocytosis in retinal glial cells and its effect on ischemia-induced neurodegeneration.
    Glia, 2017, Volume: 65, Issue:7

    Topics: Animals; Calcium-Binding Proteins; Disease Models, Animal; Doxycycline; Ependymoglial Cells; Exocytosis; Glial Fibrillary Acidic Protein; Glutamic Acid; Intermediate Filaments; Ischemia; Light; Mice; Mice, Transgenic; Microfilament Proteins; Nerve Degeneration; Protein Kinase C-alpha; Receptors, Purinergic P2Y1; Retina; Retinal Ganglion Cells; SNARE Proteins; Vascular Endothelial Growth Factor A

2017
The Cdk5-Mcl-1 axis promotes mitochondrial dysfunction and neurodegeneration in a model of Alzheimer's disease.
    Journal of cell science, 2017, Sep-15, Volume: 130, Issue:18

    Topics: Alzheimer Disease; Animals; Cell Nucleus; Cyclin-Dependent Kinase 5; Glutamic Acid; HEK293 Cells; Humans; Mice; Mitochondria; Models, Biological; Myeloid Cell Leukemia Sequence 1 Protein; Nerve Degeneration; Neurons; Neurotoxins; Phosphorylation; Phosphothreonine; Protein Transport; Proteolysis; Severity of Illness Index; Signal Transduction; Subcellular Fractions; Substrate Specificity; Ubiquitination

2017
Ndrg2 deficiency ameliorates neurodegeneration in experimental autoimmune encephalomyelitis.
    Journal of neurochemistry, 2018, Volume: 145, Issue:2

    Topics: Adaptor Proteins, Signal Transducing; Animals; Encephalomyelitis, Autoimmune, Experimental; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Glutamic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Degeneration; Proteins

2018
Agathisflavone, a flavonoid derived from Poincianella pyramidalis (Tul.), enhances neuronal population and protects against glutamate excitotoxicity.
    Neurotoxicology, 2018, Volume: 65

    Topics: Animals; Astrocytes; Biflavonoids; Cell Death; Cerebral Cortex; Coculture Techniques; Cytokines; Excitatory Amino Acid Transporter 1; Fabaceae; Glutamate-Ammonia Ligase; Glutamic Acid; Microglia; Nerve Degeneration; Nerve Growth Factors; Neurogenesis; Neurons; Neuroprotective Agents; Piperidines; Primary Cell Culture; Pyrazoles; Pyrimidines; Rats

2018
Streptozotocin toxicity in vitro depends on maturity of neurons.
    Toxicology and applied pharmacology, 2018, 06-01, Volume: 348

    Topics: Animals; Animals, Newborn; Calcium; Cell Death; Cells, Cultured; Cerebellum; Glutamic Acid; Nerve Degeneration; Neural Cell Adhesion Molecule L1; Neurogenesis; Neurons; Primary Cell Culture; Rats, Wistar; Sialic Acids; Streptozocin

2018
Glutamatergic nervous system degeneration in a C. elegans Tau
    Neurobiology of disease, 2018, Volume: 117

    Topics: Animals; Animals, Genetically Modified; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Calcium Signaling; Glutamic Acid; Nerve Degeneration; tau Proteins; Tauopathies

2018
MicroRNA-132 provides neuroprotection for tauopathies via multiple signaling pathways.
    Acta neuropathologica, 2018, Volume: 136, Issue:4

    Topics: Amyloid beta-Peptides; Animals; Cell Death; Glutamic Acid; Humans; Mice; Mice, Transgenic; MicroRNAs; Mutation; Nerve Degeneration; Neurites; Neurons; Primary Cell Culture; Protein Processing, Post-Translational; RNA, Long Noncoding; Signal Transduction; tau Proteins; Tauopathies

2018
Axonal degeneration induced by glutamate excitotoxicity is mediated by necroptosis.
    Journal of cell science, 2018, 11-19, Volume: 131, Issue:22

    Topics: Axons; Glutamic Acid; Humans; Necrosis; Nerve Degeneration

2018
Blockade of Rapid Influx of Extracellular Zn
    Molecular neurobiology, 2019, Volume: 56, Issue:6

    Topics: Animals; Behavior, Animal; Chelating Agents; Dopaminergic Neurons; Extracellular Space; Glutamic Acid; Male; Models, Biological; Movement Disorders; Nerve Degeneration; Paraquat; Parkinson Disease; Rats, Wistar; Reactive Oxygen Species; Substantia Nigra; Zinc

2019
Non-canonical activation of CREB mediates neuroprotection in a Caenorhabditis elegans model of excitotoxic necrosis.
    Journal of neurochemistry, 2019, Volume: 148, Issue:4

    Topics: Animals; Caenorhabditis elegans; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Enzyme Activation; Gene Expression Regulation; Glutamic Acid; Necrosis; Nerve Degeneration; Neuroprotection; Neurotoxins

2019
Rescue of degenerating neurons and cells by stem cell released molecules: using a physiological renormalization strategy.
    Physiological reports, 2019, Volume: 7, Issue:9

    Topics: Animals; Arsenites; Astrocytes; Caspase 3; Caspase 7; Cells, Cultured; Culture Media, Conditioned; Exosomes; Fibroblasts; Glutamic Acid; Humans; L-Lactate Dehydrogenase; Mesenchymal Stem Cells; Nerve Degeneration; Nerve Regeneration; Neural Stem Cells; Neurites; Oxidative Stress; Rats; Stem Cells

2019
Site-specific phosphorylation of Fbxw7 by Cdk5/p25 and its resulting decreased stability are linked to glutamate-induced excitotoxicity.
    Cell death & disease, 2019, 08-02, Volume: 10, Issue:8

    Topics: Animals; Brain; Cell Death; Cerebellar Cortex; F-Box-WD Repeat-Containing Protein 7; Gene Expression Regulation, Developmental; Glutamic Acid; HEK293 Cells; Humans; Mice; Nerve Degeneration; Nervous System; Neurons; Phosphorylation; Phosphotransferases; Primary Cell Culture; Protein Stability

2019
Subventricular zone-derived neural stem cell grafts protect against hippocampal degeneration and restore cognitive function in the mouse following intrahippocampal kainic acid administration.
    Stem cells translational medicine, 2013, Volume: 2, Issue:3

    Topics: Animals; Astrocytes; Behavior, Animal; Cell Movement; Cell Proliferation; Cell Survival; Cognition; Disease Models, Animal; Epilepsy, Temporal Lobe; Genetic Therapy; Genetic Vectors; Glutamic Acid; Green Fluorescent Proteins; Hippocampus; Insulin-Like Growth Factor I; Kainic Acid; Lentivirus; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Degeneration; Neural Stem Cells; Neurogenesis; Neurons; Spheroids, Cellular; Time Factors; Transduction, Genetic

2013
Expression, subunit composition, and function of AMPA-type glutamate receptors are changed in activated microglia; possible contribution of GluA2 (GluR-B)-deficiency under pathological conditions.
    Glia, 2013, Volume: 61, Issue:6

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Genotype; Glutamic Acid; Hippocampus; Lipopolysaccharides; Male; Mice; Mice, Inbred ICR; Mice, Knockout; Microglia; Nerve Degeneration; Neurons; Protein Transport; Receptors, AMPA; Tumor Necrosis Factor-alpha

2013
Striatal glutamate degenerates thalamic neurons.
    Journal of neuropathology and experimental neurology, 2013, Volume: 72, Issue:4

    Topics: Animals; Astrocytes; Corpus Striatum; Excitatory Amino Acid Agonists; Glutamic Acid; Male; Nerve Degeneration; Neurons; Rats; Rats, Sprague-Dawley; Thalamus

2013
Attenuation of neurological injury with early baicalein treatment following subarachnoid hemorrhage in rats.
    Journal of neurosurgery, 2013, Volume: 119, Issue:4

    Topics: Animals; Brain; Catalase; Disease Models, Animal; Excitatory Amino Acid Transporter 2; Flavonoids; Glutamic Acid; Male; Malondialdehyde; Nerve Degeneration; Neurons; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Wistar; Subarachnoid Hemorrhage; Superoxide Dismutase

2013
HPA axis activity in multiple sclerosis correlates with disease severity, lesion type and gene expression in normal-appearing white matter.
    Acta neuropathologica, 2013, Volume: 126, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Cerebrospinal Fluid; Corticotropin-Releasing Hormone; Female; Gene Expression; Glutamic Acid; Humans; Hydrocortisone; Hypothalamo-Hypophyseal System; Male; Middle Aged; Mood Disorders; Multiple Sclerosis; Nerve Degeneration; Nerve Fibers, Myelinated; Neurofilament Proteins; Neurons; Pituitary-Adrenal System; Severity of Illness Index; tau Proteins; Tissue Banks; Transcriptome

2013
Anti-oxidative and anti-inflammatory effects of 2-cyclopropylimino-3-methyl-1,3-thiazoline hydrochloride on glutamate-induced neurotoxicity in rat brain.
    Neurotoxicology, 2013, Volume: 38

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Brain; Calcium; Caspase 3; Excitatory Amino Acid Antagonists; Extracellular Signal-Regulated MAP Kinases; Glutamic Acid; Interferon-gamma; Lipid Peroxidation; Male; Membrane Potentials; NADPH Oxidases; Nerve Degeneration; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase Type I; Rats; Reactive Oxygen Species; Thiazoles; Tumor Necrosis Factor-alpha

2013
A compound CP-31398 suppresses excitotoxicity-induced neurodegeneration.
    Biochemical and biophysical research communications, 2013, Oct-25, Volume: 440, Issue:3

    Topics: Animals; Apoptosis; Axons; Cells, Cultured; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Mitochondria; Nerve Degeneration; Oxidoreductases; Pyrimidines; Rats; Rats, Wistar

2013
Combination of memantine and vitamin D prevents axon degeneration induced by amyloid-beta and glutamate.
    Neurobiology of aging, 2014, Volume: 35, Issue:2

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Axons; Cells, Cultured; Drug Synergism; Drug Therapy, Combination; Excitatory Amino Acid Antagonists; Glutamic Acid; Memantine; Mice; Nerve Degeneration; Neuroprotective Agents; Vitamin D

2014
Novel analogues of chlormethiazole are neuroprotective in four cellular models of neurodegeneration by a mechanism with variable dependence on GABA(A) receptor potentiation.
    British journal of pharmacology, 2014, Volume: 171, Issue:2

    Topics: Animals; Biological Availability; Brain; Calcium; Cell Hypoxia; Chlormethiazole; Chromatography, High Pressure Liquid; Excitatory Amino Acid Agonists; Female; GABA Agonists; gamma-Aminobutyric Acid; Glucose; Glutamic Acid; Mice; Mice, Inbred C57BL; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Oocytes; Pregnancy; Primary Cell Culture; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Xenopus laevis

2014
LPS-induced oxidative stress and inflammatory reaction in the rat striatum.
    Pharmacological reports : PR, 2013, Volume: 65, Issue:4

    Topics: Adenosine; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Glutamic Acid; Hydroxyl Radical; Inflammation; Injections, Intraperitoneal; Lipopolysaccharides; Microinjections; Nerve Degeneration; Neuroglia; Oxidative Stress

2013
Dual leucine zipper kinase is required for excitotoxicity-induced neuronal degeneration.
    The Journal of experimental medicine, 2013, Nov-18, Volume: 210, Issue:12

    Topics: Animals; Brain; Disks Large Homolog 4 Protein; Glutamic Acid; Guanylate Kinases; Kainic Acid; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Membrane Proteins; Mice; Mice, Knockout; N-Methylaspartate; Nerve Degeneration; Nerve Tissue Proteins; Synapses

2013
Activation of muscarinic receptors protects against retinal neurons damage and optic nerve degeneration in vitro and in vivo models.
    CNS neuroscience & therapeutics, 2014, Volume: 20, Issue:3

    Topics: Animals; Animals, Newborn; Caspase 3; Cells, Cultured; Choline O-Acetyltransferase; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glutamic Acid; Male; Muscarinic Agonists; Nerve Degeneration; Neurons; Optic Nerve; Pilocarpine; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Reperfusion Injury; Retina

2014
Novel osmotin attenuates glutamate-induced synaptic dysfunction and neurodegeneration via the JNK/PI3K/Akt pathway in postnatal rat brain.
    Cell death & disease, 2014, Jan-30, Volume: 5

    Topics: Animals; Brain; Glutamic Acid; Hippocampus; Humans; MAP Kinase Kinase 4; Nerve Degeneration; Neuronal Plasticity; Neuroprotective Agents; Phosphatidylinositol 3-Kinases; Plant Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction; Synapses

2014
Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration in vivo.
    Brain : a journal of neurology, 2014, Volume: 137, Issue:Pt 5

    Topics: alpha-Synuclein; Alzheimer Disease; Animals; Brain; Disease Models, Animal; Gene Expression Regulation; Glutamic Acid; Humans; Lewy Body Disease; Lysine; Memory Disorders; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Nerve Degeneration; Nerve Tissue Proteins; Neurons; Synapses; Thy-1 Antigens

2014
FGF-2 released from degenerating neurons exerts microglial-induced neuroprotection via FGFR3-ERK signaling pathway.
    Journal of neuroinflammation, 2014, Apr-16, Volume: 11

    Topics: Analysis of Variance; Animals; Animals, Newborn; Cell Movement; Cells, Cultured; Cerebral Cortex; Chemokine CCL3; Embryo, Mammalian; Fibroblast Growth Factor 2; Glutamic Acid; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Microglia; Nerve Degeneration; Neurons; Nitric Oxide; Phagocytosis; Receptor, Fibroblast Growth Factor, Type 3

2014
Monosodium glutamate neurotoxicity increases beta amyloid in the rat hippocampus: a potential role for cyclic AMP protein kinase.
    Neurotoxicology, 2014, Volume: 42

    Topics: AMP-Activated Protein Kinases; Amyloid beta-Peptides; Animals; Behavior, Animal; Fas Ligand Protein; Glutamic Acid; Hippocampus; Male; Nerve Degeneration; Pioglitazone; Rats; Sodium Glutamate; Thiazolidinediones

2014
Lithium/Valproic acid combination and L-glutamate induce similar pattern of changes in the expression of miR-30a-5p in SH-SY5Y neuroblastoma cells.
    Neuromolecular medicine, 2014, Volume: 16, Issue:4

    Topics: Brain-Derived Neurotrophic Factor; Cell Line, Tumor; Drug Synergism; Gene Expression Regulation; Glutamic Acid; Humans; In Vitro Techniques; Lithium; MicroRNAs; Nerve Degeneration; Neuroblastoma; Neurons; Neuroprotective Agents; Neurotoxins; Real-Time Polymerase Chain Reaction; Up-Regulation; Valproic Acid

2014
Investigating dynamic structural and mechanical changes of neuroblastoma cells associated with glutamate-mediated neurodegeneration.
    Scientific reports, 2014, Nov-17, Volume: 4

    Topics: Alzheimer Disease; Cell Line, Tumor; Glutamic Acid; Humans; Huntington Disease; Microscopy, Atomic Force; Nerve Degeneration; Neuroblastoma; Receptors, N-Methyl-D-Aspartate

2014
Effects of aging on glutamate neurotransmission in the substantia nigra of Gdnf heterozygous mice.
    Neurobiology of aging, 2015, Volume: 36, Issue:3

    Topics: Aging; Animals; Dopaminergic Neurons; Excitatory Amino Acid Transporter 2; Female; Glial Cell Line-Derived Neurotrophic Factor; Glutamic Acid; Heterozygote; Male; Mice, Inbred C57BL; Nerve Degeneration; Substantia Nigra; Subthalamic Nucleus; Synaptic Transmission

2015
Arundic acid attenuates retinal ganglion cell death by increasing glutamate/aspartate transporter expression in a model of normal tension glaucoma.
    Cell death & disease, 2015, Mar-19, Volume: 6

    Topics: Animals; Caprylates; Cell Death; Excitatory Amino Acid Transporter 1; Gene Expression Regulation; Glaucoma; Glioblastoma; Glutamic Acid; Humans; Mice; Nerve Degeneration; Optic Nerve; Retinal Ganglion Cells

2015
Evidence for early neurodegeneration in the cervical cord of patients with primary progressive multiple sclerosis.
    Brain : a journal of neurology, 2015, Volume: 138, Issue:Pt 6

    Topics: Adolescent; Adult; Aged; Aspartic Acid; Atrophy; Brain; Case-Control Studies; Cervical Cord; Disability Evaluation; Early Diagnosis; Female; Glutamic Acid; Glutamine; Gray Matter; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Multiple Sclerosis, Chronic Progressive; Nerve Degeneration; Proton Magnetic Resonance Spectroscopy; Spinal Cord; White Matter; Young Adult

2015
Death Associated Protein Kinase (DAPK) -mediated neurodegenerative mechanisms in nematode excitotoxicity.
    BMC neuroscience, 2015, Apr-23, Volume: 16

    Topics: Animals; Animals, Genetically Modified; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Cell Death; Death-Associated Protein Kinases; Gene Knockout Techniques; Glutamic Acid; Head; Locomotion; Nerve Degeneration; Neurons; Neurotoxins; NIMA-Interacting Peptidylprolyl Isomerase; Peptidylprolyl Isomerase; Protein Serine-Threonine Kinases

2015
Time-Dependent Protection of CB2 Receptor Agonist in Stroke.
    PloS one, 2015, Volume: 10, Issue:7

    Topics: Animals; Behavior, Animal; Brain Ischemia; Calcium-Binding Proteins; Cannabinoid Receptor Agonists; Cannabinoids; Cerebral Cortex; Glutamic Acid; Male; Microfilament Proteins; Nerve Degeneration; Neurons; Neuroprotection; Pioglitazone; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; RNA, Messenger; Stroke; Thiazolidinediones; Time Factors; Toll-Like Receptor 4

2015
Neurodegeneration and the Brain Tumor Microenvironment. [corrected].
    Current neuropharmacology, 2015, Volume: 13, Issue:2

    Topics: Amino Acid Transport Systems; Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain Neoplasms; Glutamic Acid; Humans; Models, Molecular; Nerve Degeneration; Reactive Oxygen Species; Sulfasalazine; Transient Receptor Potential Channels

2015
Contra-directional Coupling of Nur77 and Nurr1 in Neurodegeneration: A Novel Mechanism for Memantine-Induced Anti-inflammation and Anti-mitochondrial Impairment.
    Molecular neurobiology, 2016, Volume: 53, Issue:9

    Topics: Animals; Cell Survival; Cytochromes c; Dopamine Plasma Membrane Transport Proteins; Gene Knockdown Techniques; Glutamic Acid; Inflammation; Interleukin-6; L-Lactate Dehydrogenase; MAP Kinase Signaling System; Memantine; Mitochondria; Nerve Degeneration; Neuroprotection; Nuclear Receptor Subfamily 4, Group A, Member 1; Nuclear Receptor Subfamily 4, Group A, Member 2; Oxidopamine; PC12 Cells; Rats; Subcellular Fractions; Tumor Necrosis Factor-alpha; Tyrosine 3-Monooxygenase

2016
Altered glutamate release in the dorsal striatum of the MitoPark mouse model of Parkinson's disease.
    Brain research, 2016, 11-15, Volume: 1651

    Topics: Animals; Corpus Striatum; Dopamine; Excitatory Amino Acid Transporter 2; Glial Fibrillary Acidic Protein; Glutamic Acid; Kinetics; Male; Mice, Transgenic; Mitochondria; Nerve Degeneration; Neurotransmitter Agents; Parkinsonian Disorders; Potassium Chloride; Receptor, Metabotropic Glutamate 5; Synaptic Transmission

2016
IL-17 signalling in astrocytes promotes glutamate excitotoxicity: Indications for the link between inflammatory and neurodegenerative events in multiple sclerosis.
    Multiple sclerosis and related disorders, 2017, Volume: 11

    Topics: Animals; Astrocytes; Calcium; Cations, Divalent; Cells, Cultured; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Glutamic Acid; Multiple Sclerosis; Nerve Degeneration; Rats; Recombinant Proteins

2017
Role of Cytosolic Carboxypeptidase 5 in Neuronal Survival and Spermatogenesis.
    Scientific reports, 2017, 01-27, Volume: 7

    Topics: Animals; Carboxypeptidases; Cell Death; Cell Survival; Cerebellum; Cytosol; Female; Glutamic Acid; Male; Mice; Mice, Knockout; Nerve Degeneration; Neurons; Phenotype; Polyglutamic Acid; Purkinje Cells; Recombinant Proteins; RNA Splicing; Spermatogenesis; Spermatozoa; Substrate Specificity; Sus scrofa; Testis; Tubulin

2017
Neuroprotective effects of intrastriatal injection of rapamycin in a mouse model of excitotoxicity induced by quinolinic acid.
    Journal of neuroinflammation, 2017, 01-31, Volume: 14, Issue:1

    Topics: Animals; Body Weight; Corpus Striatum; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Glutamic Acid; Male; Mice; Mice, Inbred C57BL; Movement Disorders; Nerve Degeneration; Neuroglia; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; Postural Balance; Potassium Chloride; Quinolinic Acid; Sirolimus; Synaptosomes

2017
Medial septal beta-amyloid 1-40 injections alter septo-hippocampal anatomy and function.
    Neurobiology of aging, 2010, Volume: 31, Issue:1

    Topics: Acetylcholine; Action Potentials; Alzheimer Disease; Amyloid beta-Peptides; Animals; Cholinergic Fibers; Disease Models, Animal; Glutamic Acid; Hippocampus; Male; Nerve Degeneration; Neural Pathways; Neurons; Peptide Fragments; Rats; Rats, Sprague-Dawley; Septal Nuclei; Theta Rhythm

2010
Selenium compounds counteract the stimulation of ecto-nucleotidase activities in rat cultured cerebellar granule cells: putative correlation with neuroprotective effects.
    Brain research, 2008, Jul-24, Volume: 1221

    Topics: Adenosine Triphosphatases; Animals; Antioxidants; Azoles; Brain Damage, Chronic; Cells, Cultured; Cerebellum; Chromans; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethylmaleimide; Glutamic Acid; Isoindoles; Nerve Degeneration; Neurons; Neuroprotective Agents; Nucleotides; Organoselenium Compounds; Oxidative Stress; Rats; Selenium

2008
Enhanced expression of RNase L as a novel intracellular signal generated by NMDA receptors in mouse cortical neurons.
    Neurochemistry international, 2008, Volume: 53, Issue:3-4

    Topics: Animals; Cell Compartmentation; Cell Death; Cells, Cultured; Cerebral Cortex; Endoribonucleases; Excitatory Amino Acid Antagonists; Glutamic Acid; Mice; Nerve Degeneration; Neurons; Neurotoxins; Receptors, N-Methyl-D-Aspartate; RNA Stability; RNA, Messenger; Signal Transduction; Time Factors

2008
CDP-choline protects motor neurons against apoptotic changes in a model of chronic glutamate excitotoxicity in vitro.
    Folia neuropathologica, 2008, Volume: 46, Issue:2

    Topics: Animals; Animals, Newborn; Apoptosis; Apoptosis Regulatory Proteins; Cytidine Diphosphate Choline; Glutamic Acid; In Vitro Techniques; Motor Neuron Disease; Nerve Degeneration; Neuroglia; Neurotoxins; Rats; Spinal Cord

2008
Glutamate mobilizes [Zn2+] through Ca2+ -dependent reactive oxygen species accumulation.
    Journal of neurochemistry, 2008, Volume: 106, Issue:5

    Topics: Animals; Calcium; Calcium Signaling; Cells, Cultured; Chelating Agents; Cytosol; Fluorescent Dyes; Fura-2; Glutamic Acid; Intracellular Fluid; Mitochondria; Nerve Degeneration; Neurons; Oxidants; Oxidative Stress; Polycyclic Compounds; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptors, Glutamate; Zinc

2008
Mechanism of neuroprotection by donepezil pretreatment in rat cortical neurons chronically treated with donepezil.
    Journal of neuroscience research, 2008, Volume: 86, Issue:16

    Topics: Animals; Apoptosis; Cells, Cultured; Cerebral Cortex; Cholinesterase Inhibitors; Cytoprotection; Donepezil; Enzyme Inhibitors; Glutamic Acid; Indans; Ionomycin; Ionophores; MAP Kinase Signaling System; Necrosis; Nerve Degeneration; Neurons; Neuroprotective Agents; Nicotinic Antagonists; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Piperidines; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Receptors, Nicotinic; Signal Transduction

2008
Reduced retinal function in amyloid precursor protein-over-expressing transgenic mice via attenuating glutamate-N-methyl-d-aspartate receptor signaling.
    Journal of neurochemistry, 2008, Volume: 107, Issue:1

    Topics: Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Down-Regulation; Enzyme Inhibitors; Evoked Potentials, Visual; Glutamic Acid; Humans; Mice; Mice, Transgenic; Nerve Degeneration; Peptide Fragments; Presenilin-1; Receptors, N-Methyl-D-Aspartate; Retinal Diseases; Retinal Ganglion Cells; Signal Transduction; Vision, Ocular

2008
Nerve growth factor inhibits Gd(3+)-sensitive calcium influx and reduces chemical anoxic neuronal death.
    Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, 2008, Volume: 28, Issue:4

    Topics: Animals; Animals, Newborn; Calcium; Cell Death; Cell Hypoxia; Cells, Cultured; Excitatory Amino Acid Antagonists; Gadolinium; Glutamic Acid; Hippocampus; Nerve Degeneration; Nerve Growth Factor; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley

2008
Enhanced glutamatergic phenotype of mesencephalic dopamine neurons after neonatal 6-hydroxydopamine lesion.
    Neuroscience, 2008, Sep-22, Volume: 156, Issue:1

    Topics: Animals; Animals, Newborn; Disease Models, Animal; Dopamine; Glutamic Acid; Male; Mesencephalon; Nerve Degeneration; Neural Pathways; Neuronal Plasticity; Neurons; Nucleus Accumbens; Oxidopamine; Parkinsonian Disorders; Phenotype; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; RNA, Messenger; Substantia Nigra; Sympatholytics; Tyrosine 3-Monooxygenase; Ventral Tegmental Area; Vesicular Glutamate Transport Protein 2

2008
Blockade of microglial glutamate release protects against ischemic brain injury.
    Experimental neurology, 2008, Volume: 214, Issue:1

    Topics: Animals; Brain Ischemia; Carbenoxolone; Diazooxonorleucine; Dose-Response Relationship, Drug; Gap Junctions; Gerbillinae; Glutamic Acid; Male; Microglia; Nerve Degeneration; Neurons

2008
Evidence that TRPC1 is involved in hippocampal glutamate-induced cell death.
    Neuroscience letters, 2008, Dec-03, Volume: 446, Issue:2-3

    Topics: Animals; Animals, Newborn; Atrophy; Boron Compounds; Calcium; Calcium Signaling; Cell Death; Down-Regulation; Glutamic Acid; Hippocampus; Mice; Mice, Inbred C57BL; Nerve Degeneration; Neurodegenerative Diseases; Neurons; Neurotoxins; Organ Culture Techniques; RNA Interference; TRPC Cation Channels

2008
Repeated immobilization stress alters rat hippocampal and prefrontal cortical morphology in parallel with endogenous agmatine and arginine decarboxylase levels.
    Neurochemistry international, 2008, Volume: 53, Issue:6-8

    Topics: Agmatine; Animals; Carboxy-Lyases; Corticosterone; Glutamic Acid; Hippocampus; Male; Nerve Degeneration; Neuroprotective Agents; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Restraint, Physical; Stress, Psychological; Tubulin; Up-Regulation

2008
Ferritin, a protein containing iron nanoparticles, induces reactive oxygen species formation and inhibits glutamate uptake in rat brain synaptosomes.
    Brain research, 2008, Nov-19, Volume: 1241

    Topics: Animals; Brain; Carbon Radioisotopes; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ferritins; Free Radicals; Glutamic Acid; Male; NADP; Nanoparticles; Nerve Degeneration; Neurons; Oxidative Stress; Presynaptic Terminals; Rats; Rats, Wistar; Reactive Oxygen Species; Synaptosomes; Uncoupling Agents

2008
Necrotic neurons enhance microglial neurotoxicity through induction of glutaminase by a MyD88-dependent pathway.
    Journal of neuroinflammation, 2008, Oct-09, Volume: 5

    Topics: Animals; Cells, Cultured; Culture Media, Conditioned; Cytokines; Encephalitis; Gliosis; Glutamic Acid; Glutaminase; Inflammation Mediators; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Myeloid Differentiation Factor 88; Necrosis; Nerve Degeneration; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Toll-Like Receptors; Up-Regulation

2008
Conditioned medium from mesenchymal stem cells induces cell death in organotypic cultures of rat hippocampus and aggravates lesion in a model of oxygen and glucose deprivation.
    Neuroscience research, 2009, Volume: 63, Issue:1

    Topics: Animals; Cell Death; Cells, Cultured; Culture Media, Conditioned; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Hypoxia-Ischemia, Brain; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Nerve Degeneration; Organ Culture Techniques; Propidium; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate

2009
Reduced early hypoxic/ischemic brain damage is associated with increased GLT-1 levels in mice expressing mutant (P301L) human tau.
    Brain research, 2009, Jan-09, Volume: 1247

    Topics: Amino Acid Sequence; Animals; Apoptosis; Brain Infarction; Calpain; Caspase 3; Cytoprotection; Excitatory Amino Acid Transporter 2; Glutamic Acid; Humans; Hypoxia-Ischemia, Brain; In Situ Nick-End Labeling; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Degeneration; Organ Culture Techniques; tau Proteins; Up-Regulation

2009
Common key-signals in learning and neurodegeneration: focus on excito-amino acids, beta-amyloid peptides and alpha-synuclein.
    Journal of neural transmission (Vienna, Austria : 1996), 2009, Volume: 116, Issue:8

    Topics: alpha-Synuclein; Amyloid beta-Peptides; Animals; Brain; Dopamine; Glutamic Acid; Homocysteine; Humans; Learning; Models, Neurological; Nerve Degeneration; Neurodegenerative Diseases; Neuronal Plasticity; Neurons; Protein Conformation; Protein Multimerization; Signal Transduction

2009
Protein trafficking, targeting, and interaction at the glutamate synapse.
    Neuroscience, 2009, Jan-12, Volume: 158, Issue:1

    Topics: Animals; Astrocytes; Central Nervous System; Glutamic Acid; Humans; Nerve Degeneration; Nerve Tissue Proteins; Neurotoxins; Protein Transport; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission

2009
Fgf-2 overexpression increases excitability and seizure susceptibility but decreases seizure-induced cell loss.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008, Dec-03, Volume: 28, Issue:49

    Topics: Animals; Cell Death; Convulsants; Disease Models, Animal; Epilepsy; Female; Fibroblast Growth Factor 2; Genetic Predisposition to Disease; Glutamic Acid; Growth Cones; Hippocampus; Humans; Male; Membrane Potentials; Mice; Mice, Transgenic; Nerve Degeneration; Neuronal Plasticity; Organ Culture Techniques; Patch-Clamp Techniques; Presynaptic Terminals; Pyramidal Cells; Synaptic Vesicles

2008
Impaired calcium homeostasis in aged hippocampal neurons.
    Neuroscience letters, 2009, Feb-20, Volume: 451, Issue:2

    Topics: Aging; Animals; Calcium; Calcium Signaling; Calpain; Cells, Cultured; Cellular Senescence; Glutamic Acid; Hippocampus; Hydrogen Peroxide; Nerve Degeneration; Neurons; Neurotoxins; Organic Chemicals; Oxidants; Oxidative Stress; Rats; Rats, Sprague-Dawley

2009
Iron is a potential key mediator of glutamate excitotoxicity in spinal cord motor neurons.
    Brain research, 2009, Feb-27, Volume: 1257

    Topics: Analysis of Variance; Animals; Aspartic Acid; Cation Transport Proteins; Deferoxamine; Ferritins; Glutamic Acid; Immunoblotting; Immunohistochemistry; In Vitro Techniques; Iron; Iron Chelating Agents; L-Lactate Dehydrogenase; Lipid Peroxidation; Motor Neurons; Nerve Degeneration; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, Transferrin; Spinal Cord

2009
Reduced expression of excitatory amino acid transporter 2 and diffuse microglial activation in the cerebral cortex in AIDS cases with or without HIV encephalitis.
    Journal of neuropathology and experimental neurology, 2009, Volume: 68, Issue:2

    Topics: Acquired Immunodeficiency Syndrome; AIDS Dementia Complex; Astrocytes; Biomarkers; Cerebral Cortex; Cytoprotection; Down-Regulation; Excitatory Amino Acid Transporter 2; Gliosis; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; HIV Core Protein p24; Humans; Immunohistochemistry; Interleukin-1beta; Microglia; Nerve Degeneration; Tumor Necrosis Factor-alpha

2009
[Therapeutic strategy against multiple sclerosis].
    Rinsho shinkeigaku = Clinical neurology, 2008, Volume: 48, Issue:11

    Topics: Animals; Aptamers, Nucleotide; Autoimmunity; Axons; Cytokines; Enzyme Inhibitors; Gap Junctions; Glutamic Acid; Glutaminase; Humans; Interferon-beta; Macrophages; Microglia; Midkine; Multiple Sclerosis; Nerve Degeneration; T-Lymphocytes, Regulatory; Th1 Cells; Th2 Cells

2008
Chronic glutamate toxicity in mouse cortical neuron culture.
    Brain research, 2009, Jun-01, Volume: 1273

    Topics: Acute Disease; Animals; Cell Death; Cell Differentiation; Cells, Cultured; Chronic Disease; Dose-Response Relationship, Drug; Glutamic Acid; Mice; Nerve Degeneration; Neurons; Neurotoxins; Receptors, Glutamate; Receptors, Metabotropic Glutamate; Stem Cells; Time Factors

2009
Hyperexcitability, persistent Na+ conductances and neurodegeneration in amyotrophic lateral sclerosis.
    Experimental neurology, 2009, Volume: 218, Issue:1

    Topics: Amyotrophic Lateral Sclerosis; Animals; Biophysical Phenomena; Cerebral Cortex; Glutamic Acid; Humans; Nerve Degeneration; Neural Conduction; Sodium Channels

2009
Abnormal sensitivity of cannabinoid CB1 receptors in the striatum of mice with experimental amyotrophic lateral sclerosis.
    Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases, 2010, Volume: 11, Issue:1-2

    Topics: Amyotrophic Lateral Sclerosis; Animals; Corpus Striatum; Disease Models, Animal; Dronabinol; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Genotype; Glutamic Acid; Male; Mice; Mice, Mutant Strains; Nerve Degeneration; Neural Inhibition; Neuroprotective Agents; Receptor, Cannabinoid, CB1; Superoxide Dismutase; Superoxide Dismutase-1; Synaptic Transmission

2010
Neuroprotective effect of memantine combined with topiramate in hypoxic-ischemic brain injury.
    Brain research, 2009, Jul-28, Volume: 1282

    Topics: Animals; Animals, Newborn; Anticonvulsants; Apoptosis; Brain; Brain Infarction; Disease Models, Animal; Excitatory Amino Acid Antagonists; Female; Fructose; Glutamic Acid; Hypoxia-Ischemia, Brain; In Situ Nick-End Labeling; Male; Memantine; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Topiramate; Treatment Outcome

2009
Pathological alterations in GABAergic interneurons and reduced tonic inhibition in the basolateral amygdala during epileptogenesis.
    Neuroscience, 2009, Sep-29, Volume: 163, Issue:1

    Topics: Amygdala; Animals; Convulsants; Down-Regulation; Epilepsy; Fluoresceins; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamic Acid; Immunohistochemistry; Inhibitory Postsynaptic Potentials; Interneurons; Kainic Acid; Male; Nerve Degeneration; Neural Inhibition; Organic Chemicals; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Kainic Acid; Staining and Labeling; Status Epilepticus; Synaptic Transmission

2009
Neonatal exposure to MK801 promotes prepulse-induced delay in startle response time in adult rats.
    Experimental brain research, 2009, Volume: 197, Issue:3

    Topics: Aging; Animals; Animals, Newborn; Apoptosis; Auditory Pathways; Biomarkers; Caspase 3; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Inferior Colliculi; Male; Nerve Degeneration; Nerve Net; Neuronal Plasticity; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sensory Gating; Time

2009
Diabetes induces neural degeneration in nucleus ambiguus (NA) and attenuates heart rate control in OVE26 mice.
    Experimental neurology, 2009, Volume: 220, Issue:1

    Topics: Animals; Autonomic Nervous System Diseases; Baroreflex; Bradycardia; Diabetes Complications; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Functional Laterality; Glutamic Acid; Heart; Heart Conduction System; Heart Rate; Medulla Oblongata; Mice; Microinjections; Motor Neurons; Nerve Degeneration; Neurodegenerative Diseases; Reflex, Abnormal; Vagus Nerve Diseases

2009
Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 2.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009, Jul-22, Volume: 29, Issue:29

    Topics: Animals; Ataxins; Calcium; Calcium Channel Blockers; Calcium Signaling; Cell Death; Cells, Cultured; Chlorocebus aethiops; COS Cells; Dantrolene; Excitatory Amino Acid Agents; Glutamic Acid; Glycine; Inositol 1,4,5-Trisphosphate Receptors; Mice; Mice, Transgenic; Motor Activity; Nerve Degeneration; Nerve Tissue Proteins; Purkinje Cells; Resorcinols; Ryanodine; Spinocerebellar Ataxias

2009
Excitotoxic motoneuron degeneration induced by glutamate receptor agonists and mitochondrial toxins in organotypic cultures of chick embryo spinal cord.
    The Journal of comparative neurology, 2009, Oct-01, Volume: 516, Issue:4

    Topics: Animals; Calcium Signaling; Chick Embryo; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glutamic Acid; Kainic Acid; Malonates; Mitochondria; Motor Neuron Disease; Motor Neurons; N-Methylaspartate; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Nitro Compounds; Organ Culture Techniques; Propionates; Riluzole; Spinal Cord

2009
Epigenetic regulation of neuron-dependent induction of astroglial synaptic protein GLT1.
    Glia, 2010, Volume: 58, Issue:3

    Topics: Amyotrophic Lateral Sclerosis; Animals; Animals, Newborn; Astrocytes; Cells, Cultured; Central Nervous System; CpG Islands; DNA Methylation; Epigenesis, Genetic; Excitatory Amino Acid Transporter 2; Gene Expression Regulation; Glutamic Acid; Humans; Mice; Mice, Transgenic; Motor Cortex; Motor Neurons; Nerve Degeneration; Neurons; Neurotoxins; Promoter Regions, Genetic; Repressor Proteins; Synapses; Synaptic Transmission

2010
Diminished hippocalcin expression in Huntington's disease brain does not account for increased striatal neuron vulnerability as assessed in primary neurons.
    Journal of neurochemistry, 2009, Volume: 111, Issue:2

    Topics: 3-Hydroxyacyl CoA Dehydrogenases; Animals; Caudate Nucleus; Cell Survival; Cells, Cultured; Female; Glutamic Acid; Hippocalcin; Humans; Huntington Disease; Kidney; Lentivirus; Male; Middle Aged; Mitochondria; Nerve Degeneration; Neuronal Apoptosis-Inhibitory Protein; Neurons; Neurotoxins; Rats; RNA, Messenger

2009
Autoantibodies to glutamate receptor GluRepsilon2 in a patient with limbic encephalitis associated with relapsing polychondritis.
    Journal of the neurological sciences, 2009, Dec-15, Volume: 287, Issue:1-2

    Topics: Amygdala; Anti-Inflammatory Agents; Anticonvulsants; Atrophy; Autoantibodies; Biomarkers; Brain; Cartilage; Disease Progression; Glutamic Acid; Hippocampus; Humans; Limbic Encephalitis; Limbic System; Magnetic Resonance Imaging; Male; Methylprednisolone; Middle Aged; Nerve Degeneration; Phenytoin; Polychondritis, Relapsing; Receptors, N-Methyl-D-Aspartate; Seizures; Synaptic Transmission; Temporal Lobe; Treatment Outcome

2009
Thyrotropin-releasing hormone d,l polylactide nanoparticles (TRH-NPs) protect against glutamate toxicity in vitro and kindling development in vivo.
    Brain research, 2009, Dec-15, Volume: 1303

    Topics: Administration, Intranasal; Amygdala; Animals; Biological Availability; Cells, Cultured; Drug Delivery Systems; Electroencephalography; Epilepsy; Epilepsy, Temporal Lobe; Evoked Potentials; Glutamic Acid; Hippocampus; Kindling, Neurologic; Nanoparticles; Nerve Degeneration; Neuroprotective Agents; Polyesters; Rats; Rats, Sprague-Dawley; Thyrotropin-Releasing Hormone; Treatment Outcome

2009
The neuroprotective effect of cannabidiol in an in vitro model of newborn hypoxic-ischemic brain damage in mice is mediated by CB(2) and adenosine receptors.
    Neurobiology of disease, 2010, Volume: 37, Issue:2

    Topics: Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Aging; Animals; Animals, Newborn; Apoptosis; Brain; Cannabidiol; Caspase Inhibitors; Caspases; Cytoprotection; Disease Models, Animal; Down-Regulation; Glutamic Acid; Hypoxia-Ischemia, Brain; Inflammation Mediators; Interleukin-6; Mice; Mice, Inbred C57BL; Nerve Degeneration; Neuroprotective Agents; Organ Culture Techniques; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptor, Adenosine A1; Receptor, Adenosine A2A; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Purinergic P1

2010
Calcium homeostasis of acutely denervated and lesioned dentate gyrus in organotypic entorhino-hippocampal co-cultures.
    Cell calcium, 2010, Volume: 47, Issue:3

    Topics: Animals; Calcium; Calcium Signaling; Coculture Techniques; Dendrites; Denervation; Dentate Gyrus; Entorhinal Cortex; Glutamic Acid; Hippocampus; Homeostasis; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Nerve Degeneration; Neural Pathways; Neuronal Plasticity; Organ Culture Techniques; Perforant Pathway; Up-Regulation

2010
Glutamine synthetase down-regulation reduces astrocyte protection against glutamate excitotoxicity to neurons.
    Neurochemistry international, 2010, Volume: 56, Issue:4

    Topics: Animals; Apoptosis; Astrocytes; Blotting, Western; Cell Survival; Cells, Cultured; Down-Regulation; Excitatory Amino Acids; Glutamate-Ammonia Ligase; Glutamic Acid; Nerve Degeneration; Neurons; Plasmids; Rats; Rats, Sprague-Dawley; Transfection; Tumor Necrosis Factor-alpha

2010
Glutamate induces neurotrophic factor production from microglia via protein kinase C pathway.
    Brain research, 2010, Mar-31, Volume: 1322

    Topics: Amino Acid Transport System X-AG; Animals; Calcium; Calcium Signaling; Cells, Cultured; Coculture Techniques; Encephalitis; Extracellular Fluid; Glutamic Acid; Mice; Mice, Inbred C57BL; Microglia; Nerve Degeneration; Nerve Growth Factors; Protein Kinase C; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Signal Transduction

2010
Contributions of poly(ADP-ribose) polymerase-1 and -2 to nuclear translocation of apoptosis-inducing factor and injury from focal cerebral ischemia.
    Journal of neurochemistry, 2010, Volume: 113, Issue:4

    Topics: Active Transport, Cell Nucleus; Animals; Apoptosis Inducing Factor; Brain; Brain Ischemia; Cell Nucleus; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glutamic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Degeneration; Neurons; Oxidative Stress; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Reperfusion Injury

2010
Suprachiasmatic nucleus neurons display endogenous resistance to excitotoxicity.
    Experimental biology and medicine (Maywood, N.J.), 2010, Volume: 235, Issue:2

    Topics: Animals; Cell Death; Cell Line; Glutamic Acid; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Rats; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Suprachiasmatic Nucleus

2010
Correlation between extracellular glutamate release and neuronal cell death in an eleven vessel occlusion model in rat.
    Brain research, 2010, Jun-25, Volume: 1342

    Topics: Animals; Apoptosis; Brain; Cerebrovascular Circulation; Disease Models, Animal; Extracellular Fluid; Glutamic Acid; Hypoxia-Ischemia, Brain; Male; Nerve Degeneration; Neurons; Rats; Rats, Sprague-Dawley

2010
The role of PARP activation in glutamate-induced necroptosis in HT-22 cells.
    Brain research, 2010, Jul-09, Volume: 1343

    Topics: Animals; Apoptosis; Apoptosis Inducing Factor; Cell Line, Transformed; Enzyme Inhibitors; Glutamic Acid; Imidazoles; Indoles; Methylnitronitrosoguanidine; Mice; Necrosis; Nerve Degeneration; Neurotoxins; Oxidative Stress; Phenanthrenes; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases

2010
Cysteine string protein-alpha prevents activity-dependent degeneration in GABAergic synapses.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010, May-26, Volume: 30, Issue:21

    Topics: Age Factors; Animals; Animals, Newborn; Astrocytes; Bicuculline; Cells, Cultured; Excitatory Amino Acid Agents; Excitatory Postsynaptic Potentials; GABA Agents; gamma-Aminobutyric Acid; Gene Expression Regulation, Developmental; Glutamic Acid; Hippocampus; HSP40 Heat-Shock Proteins; Inhibitory Postsynaptic Potentials; Membrane Proteins; Mice; Mice, Knockout; Microscopy, Confocal; Microscopy, Electron, Transmission; Mutation; Nerve Degeneration; Nerve Tissue Proteins; Neurons; Patch-Clamp Techniques; Presynaptic Terminals; Rats; Synapses

2010
Neural precursor-derived astrocytes of wobbler mice induce apoptotic death of motor neurons through reduced glutamate uptake.
    Experimental neurology, 2010, Volume: 225, Issue:1

    Topics: Animals; Apoptosis; Astrocytes; Cell Communication; Cell Death; Cells, Cultured; Coculture Techniques; Glutamic Acid; Mice; Mice, Neurologic Mutants; Motor Neurons; Nerve Degeneration; Stem Cells

2010
Metabotropic glutamate receptor-4 modulates adaptive immunity and restrains neuroinflammation.
    Nature medicine, 2010, Volume: 16, Issue:8

    Topics: Adaptive Immunity; Animals; Cell Differentiation; Cytokines; Dendritic Cells; Encephalitis; Encephalomyelitis, Autoimmune, Experimental; Glutamic Acid; Mice; Mice, Knockout; Multiple Sclerosis; Nerve Degeneration; Neuroimmunomodulation; Receptors, Metabotropic Glutamate; Signal Transduction; T-Lymphocytes, Helper-Inducer

2010
Cocaine use and abuse triggering sporadic young-onset amyotrophic lateral sclerosis.
    Neuro-degenerative diseases, 2011, Volume: 8, Issue:3

    Topics: Adult; Age of Onset; Amyotrophic Lateral Sclerosis; Cocaine; Cocaine-Related Disorders; Glutamic Acid; Humans; Male; Motor Neurons; Nerve Degeneration; Receptors, Glutamate

2011
Pathophysiologically relevant levels of hydrogen peroxide induce glutamate-independent neurodegeneration that involves activation of transient receptor potential melastatin 7 channels.
    Antioxidants & redox signaling, 2011, May-15, Volume: 14, Issue:10

    Topics: Animals; Calcium Channels; Cells, Cultured; Cerebral Cortex; Glutamic Acid; Hydrogen Peroxide; Mice; Nerve Degeneration; Neurons; Receptors, Glutamate; RNA, Small Interfering; TRPM Cation Channels

2011
Early life LiCl-pilocarpine-induced status epilepticus reduces acutely hippocampal glutamate uptake and Na+/K+ ATPase activity.
    Brain research, 2011, Jan-19, Volume: 1369

    Topics: Animals; Convulsants; Enzyme Activation; Glutamic Acid; Hippocampus; Lithium Chloride; Male; Nerve Degeneration; Pilocarpine; Rats; Rats, Wistar; Sodium-Potassium-Exchanging ATPase; Status Epilepticus

2011
Neuronal Glud1 (glutamate dehydrogenase 1) over-expressing mice: increased glutamate formation and synaptic release, loss of synaptic activity, and adaptive changes in genomic expression.
    Neurochemistry international, 2011, Volume: 59, Issue:4

    Topics: Adaptation, Physiological; Animals; Brain; Cell Polarity; Dendrites; Disease Models, Animal; Genome, Human; Glutamate Dehydrogenase; Glutamic Acid; Humans; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Degeneration; Neurons; Spinal Cord; Synaptic Transmission; Up-Regulation

2011
Cannabinoid CB1 receptors regulate neuronal TNF-α effects in experimental autoimmune encephalomyelitis.
    Brain, behavior, and immunity, 2011, Volume: 25, Issue:6

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Amidohydrolases; Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Corpus Striatum; Dizocilpine Maleate; Dronabinol; Encephalomyelitis, Autoimmune, Experimental; Endocannabinoids; Etanercept; Excitatory Postsynaptic Potentials; Female; Glutamic Acid; Immunoglobulin G; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Degeneration; Neurons; Polyunsaturated Alkamides; Receptor, Cannabinoid, CB1; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Receptors, Tumor Necrosis Factor; Tumor Necrosis Factor-alpha

2011
Dark cell change of the cerebellar Purkinje cells induced by terbutaline under transient disruption of the blood-brain barrier in adult rats: morphological evaluation.
    Journal of applied toxicology : JAT, 2012, Volume: 32, Issue:10

    Topics: Adrenergic beta-2 Receptor Agonists; Animals; Blood-Brain Barrier; Brain Edema; Cerebellum; Cytoplasmic Structures; Dendrites; Disease Models, Animal; Endoplasmic Reticulum; Glutamic Acid; Golgi Apparatus; Male; Mannitol; Nerve Degeneration; Neuroglia; Purkinje Cells; Rats; Rats, Sprague-Dawley; Staining and Labeling; Terbutaline

2012
Deletion of astroglial Dicer causes non-cell-autonomous neuronal dysfunction and degeneration.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011, Jun-01, Volume: 31, Issue:22

    Topics: Animals; Astrocytes; Cerebellum; Gene Expression Profiling; Gene Expression Regulation, Developmental; Glial Fibrillary Acidic Protein; Glutamic Acid; In Vitro Techniques; Integrases; Male; Mice; Mice, Neurologic Mutants; Mice, Transgenic; Nerve Degeneration; Nerve Tissue Proteins; Patch-Clamp Techniques; Psychomotor Disorders; Purkinje Cells; Ribonuclease III; Signal Transduction

2011
Simvastatin prevents dopaminergic neurodegeneration in experimental parkinsonian models: the association with anti-inflammatory responses.
    PloS one, 2011, Volume: 6, Issue:6

    Topics: Animals; Anti-Inflammatory Agents; Anxiety; Apoptosis; Autoradiography; Cell Survival; Disease Models, Animal; Dizocilpine Maleate; Dopamine; Glutamic Acid; Immunohistochemistry; L-Lactate Dehydrogenase; Male; Matrix Metalloproteinase 9; Nerve Degeneration; Oxidopamine; Parkinson Disease; PC12 Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Simvastatin; Substantia Nigra; Tritium; Tumor Necrosis Factor-alpha; Tyrosine 3-Monooxygenase

2011
Sera from amyotrophic lateral sclerosis patients induce the non-canonical activation of NMDA receptors "in vitro".
    Neurochemistry international, 2011, Volume: 59, Issue:6

    Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Animals; Blood Proteins; Calcium Signaling; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Female; Glutamic Acid; Humans; In Vitro Techniques; Male; Middle Aged; Nerve Degeneration; Neurotoxins; Oocytes; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Xenopus laevis

2011
Endothelin receptors A and B are expressed in distinct cellular compartments of rat hippocampus following global ischemia: an immunocytochemical study.
    Neurological research, 2011, Volume: 33, Issue:2

    Topics: Animals; Brain Ischemia; Cell Compartmentation; Cell Survival; Disease Models, Animal; Endothelins; Glutamic Acid; Immunohistochemistry; Male; Mossy Fibers, Hippocampal; Nerve Degeneration; Neurons; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B

2011
Who is resilient to depression? Multimodal imaging of the hippocampus in preclinical chronic mild stress model may provide clues.
    Biological psychiatry, 2011, Sep-01, Volume: 70, Issue:5

    Topics: Animals; Depressive Disorder, Major; Diffusion Tensor Imaging; Dipeptides; Disease Models, Animal; Glutamic Acid; Hippocampus; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Nerve Degeneration; Rats; Stress, Psychological

2011
Pharmacological enhancement of glutamate transport reduces excitotoxicity in vitro.
    Restorative neurology and neuroscience, 2011, Volume: 29, Issue:5

    Topics: Animals; Animals, Newborn; Anti-Bacterial Agents; Ceftriaxone; Cells, Cultured; Coculture Techniques; Excitatory Amino Acid Transporter 1; Glucose Transporter Type 1; Glutamic Acid; Nerve Degeneration; Neurotoxins; Proline; Rats; Rats, Sprague-Dawley; Up-Regulation

2011
Oncogene AEG-1 promotes glioma-induced neurodegeneration by increasing glutamate excitotoxicity.
    Cancer research, 2011, Oct-15, Volume: 71, Issue:20

    Topics: Animals; Astrocytes; Brain; Brain Neoplasms; Cell Adhesion Molecules; Cell Line, Tumor; CREB-Binding Protein; Excitatory Amino Acid Transporter 2; Glioma; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Humans; Membrane Proteins; Nerve Degeneration; Oncogenes; Promoter Regions, Genetic; Rats; RNA-Binding Proteins; YY1 Transcription Factor

2011
Selective mGluR1 antagonist EMQMCM inhibits the kainate-induced excitotoxicity in primary neuronal cultures and in the rat hippocampus.
    Neurotoxicity research, 2012, Volume: 21, Issue:4

    Topics: Animals; Apoptosis; Caspase 3; Cerebral Cortex; Dose-Response Relationship, Drug; Drug Interactions; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Kainic Acid; L-Lactate Dehydrogenase; Male; Mice; Microinjections; Nerve Degeneration; Neuroprotective Agents; Primary Cell Culture; Quinolines; Rats; Rats, Wistar

2012
Cytosolic carboxypeptidase 1 is involved in processing α- and β-tubulin.
    The Journal of biological chemistry, 2012, Feb-24, Volume: 287, Issue:9

    Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Colonic Neoplasms; Cytosol; Female; Glutamic Acid; GTP-Binding Proteins; HEK293 Cells; Humans; Mice; Mice, Inbred BALB C; Mice, Mutant Strains; Nerve Degeneration; Peptide Synthases; Protein Structure, Tertiary; Purkinje Cells; Serine-Type D-Ala-D-Ala Carboxypeptidase; Swine; Tubulin

2012
Effects of adrenergic agents on intracellular Ca2+ homeostasis and metabolism of glucose in astrocytes with an emphasis on pyruvate carboxylation, oxidative decarboxylation and recycling: implications for glutamate neurotransmission and excitotoxicity.
    Neurotoxicity research, 2012, Volume: 21, Issue:4

    Topics: Adrenergic Agents; Animals; Astrocytes; Calcium; Carboxy-Lyases; Citric Acid Cycle; Cytoplasm; Decarboxylation; Glucose; Glutamic Acid; Glycogen; Homeostasis; Mice; Nerve Degeneration; Norepinephrine; Oxidation-Reduction; Primary Cell Culture; Pyruvic Acid; Synaptic Transmission

2012
Hypothermia and rewarming injury in hippocampal neurons involve intracellular Ca2+ and glutamate excitotoxicity.
    Neuroscience, 2012, Apr-05, Volume: 207

    Topics: Animals; Body Temperature; Calcium Signaling; Glutamic Acid; Hippocampus; Hypothermia, Induced; Intracellular Fluid; Nerve Degeneration; Neurons; Neurotoxins; Organ Culture Techniques; Rats; Rats, Sprague-Dawley

2012
Chronic excitotoxin-induced axon degeneration in a compartmented neuronal culture model.
    ASN neuro, 2012, Feb-23, Volume: 4, Issue:1

    Topics: Animals; Axons; Blotting, Western; Cell Culture Techniques; Excitatory Amino Acids; Glutamic Acid; Immunohistochemistry; Mice; Mice, Inbred C57BL; Nerve Degeneration; Neurons; Receptors, Glutamate

2012
Dynein and dynactin components modulate neurodegeneration induced by excitotoxicity.
    Journal of neurochemistry, 2012, Volume: 122, Issue:1

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Animals; Antibodies, Monoclonal; Apoptosis; Axons; Cells, Cultured; Dynactin Complex; Dyneins; Embryo, Mammalian; Excitatory Amino Acids; Female; Frontal Lobe; Gene Expression Regulation; Glutamic Acid; Green Fluorescent Proteins; Hippocampus; Humans; Male; Microtubule-Associated Proteins; Mutation; Nerve Degeneration; Neurons; Protein Transport; Rats; Rats, Wistar; RNA, Small Interfering; Transfection

2012
Water extract from the leaves of Withania somnifera protect RA differentiated C6 and IMR-32 cells against glutamate-induced excitotoxicity.
    PloS one, 2012, Volume: 7, Issue:5

    Topics: Animals; Cell Death; Cell Differentiation; Cell Line; Excitatory Amino Acid Antagonists; Glial Fibrillary Acidic Protein; Glutamic Acid; HSP70 Heat-Shock Proteins; Humans; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Nerve Degeneration; Neural Cell Adhesion Molecules; Neurofilament Proteins; Neurons; Neuroprotective Agents; Neurotoxins; Plant Extracts; Plant Leaves; Plants, Medicinal; Rats; Tretinoin; Withania

2012
Cooperative effect of p150Glued and microtubule stabilization to suppress excitotoxicity-induced axon degeneration.
    Biochemical and biophysical research communications, 2012, Jul-20, Volume: 424, Issue:1

    Topics: Animals; Axons; Cells, Cultured; Dynactin Complex; Glutamic Acid; Hippocampus; Microtubule-Associated Proteins; Microtubules; Nerve Degeneration; Rats; Rats, Wistar

2012
Calpain-cleaved type 1 inositol 1,4,5-trisphosphate receptor impairs ER Ca(2+) buffering and causes neurodegeneration in primary cortical neurons.
    Journal of neurochemistry, 2012, Volume: 123, Issue:1

    Topics: Analysis of Variance; Animals; Calcium; Calcium Signaling; Cell Line, Transformed; Cell Survival; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Embryo, Mammalian; Enzyme Inhibitors; Female; Gene Expression Regulation; Glutamic Acid; Humans; Inositol 1,4,5-Trisphosphate Receptors; Methoxyhydroxyphenylglycol; Microtubule-Associated Proteins; Mutagenesis, Site-Directed; Nerve Degeneration; Neurons; Point Mutation; Pregnancy; Rats; Thapsigargin; Transfection

2012
Inhibition of p53 transactivation functionally interacts with microtubule stabilization to suppress excitotoxicity-induced axon degeneration.
    Biochemical and biophysical research communications, 2012, Oct-12, Volume: 427, Issue:1

    Topics: Animals; Axons; Benzothiazoles; Cells, Cultured; Dynactin Complex; Glutamic Acid; Hippocampus; Microtubule-Associated Proteins; Microtubules; Mitochondria; Mitochondrial Diseases; Nerve Degeneration; Neurotoxins; Paclitaxel; Rats; Rats, Wistar; Toluene; Transcriptional Activation; Tumor Suppressor Protein p53

2012
Effect of nafamostat on N-methyl-D-aspartate-induced retinal neuronal and capillary degeneration in rats.
    Biological & pharmaceutical bulletin, 2012, Volume: 35, Issue:12

    Topics: Animals; Basement Membrane; Benzamidines; Capillaries; Diabetic Neuropathies; Excitatory Amino Acid Agonists; Glaucoma; Glutamic Acid; Guanidines; Intravitreal Injections; Male; N-Methylaspartate; Nerve Degeneration; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Retina; Retinal Diseases; Retinal Ganglion Cells; Retinal Neurons; Retinal Vessels; Serine Proteinase Inhibitors; Severity of Illness Index; Vascular Diseases

2012
Characterization of astrocytes derived from human NTera-2/D1 embryonal carcinoma cells.
    Journal of neuroscience research, 2002, Jun-01, Volume: 68, Issue:5

    Topics: Astrocytes; Cell Differentiation; Cell Division; Cell Lineage; Colforsin; Embryonal Carcinoma Stem Cells; Glutamate-Ammonia Ligase; Glutamic Acid; Homeostasis; Humans; In Vitro Techniques; Intermediate Filament Proteins; Neoplastic Stem Cells; Nerve Degeneration; Nerve Tissue Proteins; Nestin; Teratocarcinoma; Tumor Cells, Cultured

2002
Glutamate transporters and retinal excitotoxicity.
    Glia, 2002, Volume: 39, Issue:1

    Topics: Amino Acid Transport System X-AG; Animals; Animals, Newborn; Aspartic Acid; Glutamic Acid; Nerve Degeneration; Neuroglia; Rats; Rats, Sprague-Dawley; Retina

2002
Altered expression and phosphorylation of N-methyl-D-aspartate receptors in piglet striatum after hypoxia-ischemia.
    Brain research. Molecular brain research, 2002, Jul-15, Volume: 104, Issue:1

    Topics: Aging; Animals; Animals, Newborn; Antibody Specificity; Asphyxia Neonatorum; Corpus Striatum; Disease Models, Animal; Female; Glutamic Acid; Humans; Hypoxia-Ischemia, Brain; Immunoblotting; Infant, Newborn; Male; Nerve Degeneration; Neurons; Neurotoxins; Phosphorylation; Receptors, N-Methyl-D-Aspartate; Swine; Synaptic Transmission; Up-Regulation

2002
Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part I: creatine kinase BB, glutamine synthase, and ubiquitin carboxy-terminal hydrolase L-1.
    Free radical biology & medicine, 2002, Aug-15, Volume: 33, Issue:4

    Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Antibodies, Monoclonal; Blotting, Western; Brain Chemistry; Creatine Kinase; Creatine Kinase, BB Form; Electrophoresis, Gel, Two-Dimensional; Free Radicals; Glutamate-Ammonia Ligase; Glutamic Acid; Glutamine; Humans; Image Processing, Computer-Assisted; Isoenzymes; Nerve Degeneration; Nerve Tissue Proteins; Oxidation-Reduction; Proteomics; Rosaniline Dyes; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Staining and Labeling; Thiolester Hydrolases; Ubiquitin Thiolesterase

2002
Protection and reversal of excitotoxic neuronal damage by glucagon-like peptide-1 and exendin-4.
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 302, Issue:3

    Topics: Animals; Basal Ganglia; Cell Death; Cell Survival; Cells, Cultured; Choline O-Acetyltransferase; Cyclic AMP; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Exenatide; Glial Fibrillary Acidic Protein; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glutamic Acid; Hippocampus; Ibotenic Acid; Immunohistochemistry; Nerve Degeneration; Neurons; Parasympathetic Nervous System; Peptide Fragments; Peptides; Protein Precursors; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Receptors, Glucagon; Venoms

2002
Nitric oxide synthase inhibition and glutamate binding in quinolinate-lesioned rat hippocampus.
    Physiological research, 2002, Volume: 51, Issue:3

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding, Competitive; Cell Membrane; Excitatory Amino Acid Agonists; Glutamic Acid; Hippocampus; Kainic Acid; Male; Molsidomine; N-Methylaspartate; Nerve Degeneration; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroarginine; Quinolinic Acid; Quisqualic Acid; Rats; Rats, Wistar; Tritium

2002
Subthalamic GAD gene therapy in a Parkinson's disease rat model.
    Science (New York, N.Y.), 2002, Oct-11, Volume: 298, Issue:5592

    Topics: Animals; Dependovirus; Disease Models, Animal; Dopamine; Electric Stimulation; Electrophysiology; gamma-Aminobutyric Acid; Genetic Therapy; Genetic Vectors; Glutamate Decarboxylase; Glutamic Acid; Humans; Ibotenic Acid; Isoenzymes; Male; Mesencephalon; Mice; Motor Activity; Nerve Degeneration; Neurons; Oxidopamine; Parkinsonian Disorders; Phenotype; Rats; Stem Cells; Substantia Nigra; Subthalamic Nucleus; Synaptic Transmission; Transgenes

2002
Neurotensin enhances glutamate excitotoxicity in mesencephalic neurons in primary culture.
    Journal of neuroscience research, 2002, Dec-15, Volume: 70, Issue:6

    Topics: Animals; Cells, Cultured; Dopamine; Embryo, Mammalian; Enzyme Inhibitors; Glutamic Acid; Immunohistochemistry; Mesencephalon; Naphthalenes; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotensin; Pyrazoles; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Neurotensin; Tyrosine 3-Monooxygenase

2002
Synergistic effects of low level stressors in an oxidative damage model of spinal motor neuron degeneration.
    Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases, 2002, Volume: 3, Issue:3

    Topics: Animals; Cell Death; Cells, Cultured; Dose-Response Relationship, Drug; Drug Synergism; Embryo, Mammalian; Ganglia, Spinal; Glutamic Acid; Heating; Mice; Motor Neurons; Nerve Degeneration; Oxidation-Reduction; Oxidative Stress; Paraquat; Receptors, Kainic Acid; Spinal Cord

2002
Calcium influx constitutes the ionic basis for the maintenance of glutamate-induced extended neuronal depolarization associated with hippocampal neuronal death.
    Cell calcium, 2003, Volume: 33, Issue:2

    Topics: Animals; Animals, Newborn; Brain Injuries; Calcium; Calcium Channel Blockers; Calcium Signaling; Cell Death; Cell Membrane; Cells, Cultured; Chlorides; Excitatory Amino Acid Antagonists; Extracellular Space; Gadolinium; Glutamic Acid; Hippocampus; Membrane Potentials; Nerve Degeneration; Neurons; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Sodium-Calcium Exchanger; Stroke; Zinc Compounds

2003
Human immunodeficiency virus type 1 gp120 and ethanol coexposure in rat organotypic brain slice cultures: Curtailment of gp120-induced neurotoxicity and neurotoxic mediators by moderate but not high ethanol concentrations.
    Journal of neurovirology, 2003, Volume: 9, Issue:1

    Topics: Animals; Arachidonic Acid; Brain; Central Nervous System Depressants; Dose-Response Relationship, Drug; Drug Interactions; Ethanol; Excitatory Amino Acid Agonists; Extracellular Space; Glutamic Acid; Glycine; HIV Envelope Protein gp120; N-Methylaspartate; Nerve Degeneration; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Superoxides

2003
Therapeutic vaccine for acute and chronic motor neuron diseases: implications for amyotrophic lateral sclerosis.
    Proceedings of the National Academy of Sciences of the United States of America, 2003, Apr-15, Volume: 100, Issue:8

    Topics: Acute Disease; Amyotrophic Lateral Sclerosis; Animals; Axotomy; Cell Death; Chronic Disease; Disease Models, Animal; Facial Nerve; Female; Glatiramer Acetate; Glutamic Acid; Humans; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Motor Neuron Disease; Motor Neurons; Nerve Degeneration; Peptides; Superoxide Dismutase; Superoxide Dismutase-1; Vaccines

2003
Differences in ionotropic glutamate receptor subunit expression are not responsible for strain-dependent susceptibility to excitotoxin-induced injury.
    Brain research. Molecular brain research, 2003, Apr-10, Volume: 112, Issue:1-2

    Topics: Animals; Cell Death; Disease Models, Animal; Drug Resistance; Epilepsy; Genetic Predisposition to Disease; Glutamic Acid; Immunohistochemistry; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Nerve Degeneration; Neurotoxins; Protein Subunits; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Species Specificity; Synaptic Transmission

2003
Identification of neuronal cell death in a model of degeneration in the hippocampus.
    Brain research. Brain research protocols, 2003, Volume: 11, Issue:1

    Topics: Animals; Animals, Newborn; Axons; Biomarkers; Cell Death; Cell Line; Dendrites; Disease Models, Animal; Fluoresceins; Fluorescent Dyes; Gliosis; Glutamic Acid; Hippocampus; Male; Mice; Microglia; Nerve Degeneration; Neurons; Neurotoxins; Organ Culture Techniques; Organic Chemicals; Propidium; Rats; Rats, Wistar

2003
Topiramate protects against glutamate- and kainate-induced neurotoxicity in primary neuronal-astroglial cultures.
    Epilepsy research, 2003, Volume: 54, Issue:1

    Topics: Animals; Animals, Newborn; Anticonvulsants; Astrocytes; Calcium; Calcium Signaling; Cell Membrane; Cell Survival; Cells, Cultured; Fructose; Glutamic Acid; Immunohistochemistry; Kainic Acid; Nerve Degeneration; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; Phenytoin; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; Topiramate; Valproic Acid

2003
Interleukin-6, beta-amyloid peptide and NMDA interactions in rat cortical neurons.
    Journal of neuroimmunology, 2003, Volume: 139, Issue:1-2

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Calcium Signaling; Cell Death; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Drug Interactions; Encephalitis; Excitatory Amino Acid Agonists; Fetus; Glutamic Acid; Interleukin-6; N-Methylaspartate; Nerve Degeneration; Neurons; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate

2003
GluR2(B) knockdown accelerates CA3 injury after kainate seizures.
    Journal of neuropathology and experimental neurology, 2003, Volume: 62, Issue:7

    Topics: Animals; Calcium Signaling; Cell Death; Epilepsy; Glutamic Acid; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Nerve Degeneration; Neurons; Neurotoxins; Oligonucleotides, Antisense; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Status Epilepticus

2003
Acetylcholinesterase activation in organotypic rat hippocampal slice cultures deprived of oxygen and glucose.
    Neuroscience letters, 2003, Sep-11, Volume: 348, Issue:2

    Topics: Acetylcholine; Acetylcholinesterase; Animals; Animals, Newborn; Cell Death; Cerebral Infarction; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Hypoxia-Ischemia, Brain; Nerve Degeneration; Organ Culture Techniques; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Up-Regulation

2003
Expression of heat shock protein 70 induced by 4-aminopyridine through glutamate-mediated excitotoxic stress in rat hippocampus in vivo.
    Neuropharmacology, 2003, Volume: 45, Issue:5

    Topics: 4-Aminopyridine; Animals; Anticonvulsants; Cell Count; Chromatography, High Pressure Liquid; Dizocilpine Maleate; Drug Interactions; Electroencephalography; Epilepsy; Extracellular Space; Functional Laterality; Gene Expression; Glutamic Acid; Hippocampus; HSP70 Heat-Shock Proteins; Immunohistochemistry; Male; Microdialysis; Nerve Degeneration; Neuroprotective Agents; Piperazines; Potassium Channel Blockers; Quinoxalines; Rats; Rats, Wistar; Somatosensory Cortex; Stress, Physiological; Time Factors

2003
Learning from the gut.
    Nature medicine, 2003, Volume: 9, Issue:9

    Topics: Animals; Brain-Derived Neurotrophic Factor; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Glucose; Glutamic Acid; Insulin; Insulin Secretion; Learning; Memory; Mice; Nerve Degeneration; Neuronal Plasticity; Pancreas; Peptide Fragments; Protein Precursors; Rats; Receptors, Neurotransmitter; Signal Transduction

2003
Differential effects of natural polyphenols on neuronal survival in primary cultured central neurons against glutamate- and glucose deprivation-induced neuronal death.
    Brain research, 2003, Oct-03, Volume: 986, Issue:1-2

    Topics: Animals; Brain Ischemia; Calcium Signaling; Cell Survival; Cells, Cultured; Central Nervous System; Drugs, Chinese Herbal; Excitatory Amino Acid Agonists; Female; Flavanones; Flavonoids; Glucose; Glutamic Acid; L-Lactate Dehydrogenase; Mitochondria; Nerve Degeneration; Neurons; Neuroprotective Agents; Nitric Oxide; Phenols; Polyphenols; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Scutellaria baicalensis

2003
Effect of agmatine against cell death induced by NMDA and glutamate in neurons and PC12 cells.
    Cellular and molecular neurobiology, 2003, Volume: 23, Issue:4-5

    Topics: Agmatine; Animals; Calcimycin; Cell Death; Cerebral Cortex; Enzyme Inhibitors; Fetus; Glutamic Acid; Ionophores; L-Lactate Dehydrogenase; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; PC12 Cells; Protein Kinase Inhibitors; Protein Kinases; Rats; Staurosporine

2003
Epilepsy, neurodegeneration, and extracellular glutamate in the hippocampus of awake and anesthetized rats treated with okadaic acid.
    Neurochemical research, 2003, Volume: 28, Issue:10

    Topics: Anesthetics, Inhalation; Animals; Electroencephalography; Epilepsy; Extracellular Fluid; Glutamic Acid; Halothane; Hippocampus; Male; Microdialysis; Nerve Degeneration; Okadaic Acid; Phosphoprotein Phosphatases; Rats; Rats, Wistar; Wakefulness

2003
Changes of mGluR4 and the effects of its specific agonist L-AP4 in a rodent model of diffuse brain injury.
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2003, Volume: 10, Issue:6

    Topics: Aminobutyrates; Animals; Behavior, Animal; Brain; Brain Injuries; Cell Count; Cognition Disorders; Diffuse Axonal Injury; Disease Models, Animal; Excitatory Amino Acid Agonists; Glutamic Acid; Male; Movement Disorders; Nerve Degeneration; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; RNA, Messenger; Synaptic Transmission; Treatment Outcome

2003
Morphology and ultrastructure of rat hippocampal formation after i.c.v. administration of N-acetyl-L-aspartyl-L-glutamate.
    Neuroscience, 2003, Volume: 122, Issue:1

    Topics: Animals; Aspartic Acid; Cell Count; Cell Death; Dipeptides; DNA Fragmentation; Excitatory Amino Acid Agonists; Glutamic Acid; Hippocampus; In Situ Nick-End Labeling; Injections, Intraventricular; Male; Microscopy, Electron; Nerve Degeneration; Neurons; Neuropeptides; Neurotoxins; Rats; Rats, Wistar; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Time Factors

2003
Critical role of calpain-mediated cleavage of calcineurin in excitotoxic neurodegeneration.
    The Journal of biological chemistry, 2004, Feb-06, Volume: 279, Issue:6

    Topics: Amino Acid Sequence; Animals; Binding Sites; Calcineurin; Calpain; Cells, Cultured; Glutamic Acid; Hippocampus; Kainic Acid; Male; Mice; Models, Neurological; Molecular Sequence Data; Nerve Degeneration; Rats; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

2004
Glutamate and glutamine in the anterior cingulate and thalamus of medicated patients with chronic schizophrenia and healthy comparison subjects measured with 4.0-T proton MRS.
    The American journal of psychiatry, 2003, Volume: 160, Issue:12

    Topics: Adult; Antipsychotic Agents; Aspartic Acid; Chronic Disease; Dominance, Cerebral; Female; Glutamic Acid; Glutamine; Gyrus Cinguli; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Nerve Degeneration; Psychiatric Status Rating Scales; Reference Values; Schizophrenia; Thalamus

2003
Astrocytic regulation of NMDA receptor subunit composition modulates the toxicity of prion peptide PrP106-126.
    Molecular and cellular neurosciences, 2004, Volume: 25, Issue:1

    Topics: Animals; Animals, Newborn; Arachidonic Acid; Astrocytes; Cell Communication; Cells, Cultured; Coculture Techniques; Copper; Excitatory Amino Acid Antagonists; Glutamic Acid; Nerve Degeneration; Neurons; Peptide Fragments; Prion Diseases; Prions; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate

2004
Decreasing glutamate buffering capacity triggers oxidative stress and neuropil degeneration in the Drosophila brain.
    Current biology : CB, 2004, Apr-06, Volume: 14, Issue:7

    Topics: Animals; Brain; DNA Primers; Drosophila; Excitatory Amino Acid Antagonists; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Fluorescence; Gene Silencing; Glutamic Acid; Humans; Melatonin; Microscopy, Electron, Scanning; Movement; Nerve Degeneration; Neuropil; Oxidative Stress; Paraquat; Reverse Transcriptase Polymerase Chain Reaction; Riluzole; RNA Interference

2004
Limbic epileptogenicity, cell loss and axonal reorganization induced by audiogenic and amygdala kindling in wistar audiogenic rats (WAR strain).
    Neuroscience, 2004, Volume: 125, Issue:3

    Topics: Acoustic Stimulation; Amygdala; Animals; Cell Count; Disease Models, Animal; Disease Progression; Epilepsy, Reflex; Epilepsy, Tonic-Clonic; Female; Genetic Predisposition to Disease; Glutamic Acid; Hippocampus; Kindling, Neurologic; Limbic System; Mossy Fibers, Hippocampal; Nerve Degeneration; Neuronal Plasticity; Presynaptic Terminals; Rats; Rats, Mutant Strains; Rats, Wistar

2004
Response to kainic acid injections: changes in staining for zinc, FOS, cell death and glial response in the rat forebrain.
    Neuroscience, 2004, Volume: 125, Issue:3

    Topics: Animals; Cell Compartmentation; Cell Death; Cytoplasm; Fluoresceins; Fluorescent Dyes; Gliosis; Glutamic Acid; Kainic Acid; Male; Nerve Degeneration; Neurotoxins; Organic Chemicals; Presynaptic Terminals; Prosencephalon; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Reaction Time; Seizures; Synaptic Transmission; Synaptic Vesicles; Zinc

2004
Estrogen receptor subtypes alpha and beta contribute to neuroprotection and increased Bcl-2 expression in primary hippocampal neurons.
    Brain research, 2004, Jun-04, Volume: 1010, Issue:1-2

    Topics: Animals; Cell Survival; Cells, Cultured; Cytoprotection; Estradiol Congeners; Estrogen Receptor alpha; Estrogen Receptor beta; Estrogens; Female; Fetus; Glutamic Acid; Hippocampus; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Nitriles; Phenols; Pregnancy; Proto-Oncogene Proteins c-bcl-2; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; Up-Regulation

2004
Increased calbindin-D28K immunoreactivity in rat cerebellar Purkinje cell with excitatory amino acids agonists is not dependent on protein synthesis.
    Archives italiennes de biologie, 2004, Volume: 142, Issue:1

    Topics: Animals; Calbindin 1; Calbindins; Cerebellum; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Immunohistochemistry; Male; Nerve Degeneration; Neurotoxins; Protein Biosynthesis; Protein Synthesis Inhibitors; Purkinje Cells; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; S100 Calcium Binding Protein G; Transcription, Genetic; Up-Regulation

2004
Effects of somatosensory electrical stimulation on neuronal injury after global hypoxia-ischemia.
    Experimental brain research, 2004, Volume: 158, Issue:3

    Topics: Afferent Pathways; Animals; Caspase 3; Caspases; Cerebellum; Cerebral Infarction; Disease Models, Animal; Electric Stimulation Therapy; Evoked Potentials, Somatosensory; Extracellular Signal-Regulated MAP Kinases; Functional Laterality; Glutamic Acid; Hippocampus; Hypoxia-Ischemia, Brain; Male; Median Nerve; Nerve Degeneration; Rats; Rats, Wistar; Somatosensory Cortex

2004
Memantine inhibits and reverses the Alzheimer type abnormal hyperphosphorylation of tau and associated neurodegeneration.
    FEBS letters, 2004, May-21, Volume: 566, Issue:1-3

    Topics: 2-Amino-5-phosphonovalerate; Alzheimer Disease; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Kynurenic Acid; Memantine; Microtubule-Associated Proteins; Nerve Degeneration; Neurofibrils; Neuroprotective Agents; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Rats; Rats, Wistar; tau Proteins

2004
Incubation of nerve endings with a physiological concentration of Abeta1-42 activates CaV2.2(N-Type)-voltage operated calcium channels and acutely increases glutamate and noradrenaline release.
    Journal of Alzheimer's disease : JAD, 2004, Volume: 6, Issue:3

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cerebral Cortex; Female; Glutamic Acid; Hippocampus; Male; Nerve Degeneration; Nerve Endings; Nerve Tissue Proteins; Norepinephrine; Peptide Fragments; Plaque, Amyloid; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Rats, Wistar; Reactive Oxygen Species

2004
Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004, Jun-30, Volume: 24, Issue:26

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Animals; Apoptosis; bcl-2-Associated X Protein; Cells, Cultured; Dizocilpine Maleate; Gene Expression Regulation; Glutamic Acid; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Immunoenzyme Techniques; Intercellular Signaling Peptides and Proteins; Nerve Degeneration; Nerve Tissue Proteins; Neurofibrillary Tangles; Neurons; Oligodeoxyribonucleotides; Peptide Fragments; Phosphorylation; Protein Processing, Post-Translational; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Quinoxalines; Rats; RNA, Messenger; Signal Transduction; tau Proteins; Tumor Suppressor Protein p53; Wnt Proteins

2004
Dopamine, through the extracellular signal-regulated kinase pathway, downregulates CD4+CD25+ regulatory T-cell activity: implications for neurodegeneration.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004, Jul-07, Volume: 24, Issue:27

    Topics: Animals; CD4-Positive T-Lymphocytes; Cell Adhesion; Cell Movement; Cell Separation; Cell Survival; Cells, Cultured; Disease Models, Animal; Dopamine; Dopamine Agonists; Down-Regulation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Glutamic Acid; Immune Tolerance; Mice; Nerve Crush; Nerve Degeneration; Neuroprotective Agents; Optic Nerve; Optic Nerve Injuries; Receptors, Dopamine D1; Receptors, Dopamine D5; Receptors, Interleukin-2; Retinal Ganglion Cells; Signal Transduction

2004
Expression of glutamate receptors and calcium-binding proteins in the retina of streptozotocin-induced diabetic rats.
    Brain research, 2004, Aug-20, Volume: 1018, Issue:1

    Topics: Amacrine Cells; Animals; Calbindins; Calcium-Binding Proteins; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Disease Models, Animal; Glutamic Acid; Immunohistochemistry; Male; Nerve Degeneration; Neurons; Parvalbumins; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Retina; Retinal Ganglion Cells; S100 Calcium Binding Protein G; Synaptic Transmission; Up-Regulation

2004
Involvement of RhoA and possible neuroprotective effect of fasudil, a Rho kinase inhibitor, in NMDA-induced neurotoxicity in the rat retina.
    Brain research, 2004, Aug-20, Volume: 1018, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Count; Disease Models, Animal; Drug Interactions; Enzyme Inhibitors; Glutamic Acid; Intracellular Signaling Peptides and Proteins; Male; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Protein Serine-Threonine Kinases; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Retina; Retinal Degeneration; Retinal Ganglion Cells; rho-Associated Kinases; rhoA GTP-Binding Protein; RNA, Messenger; Thy-1 Antigens; Up-Regulation

2004
Estrogen attenuates neuronal excitability in the insular cortex following middle cerebral artery occlusion.
    Brain research, 2004, Aug-20, Volume: 1018, Issue:1

    Topics: Action Potentials; Animals; Cerebral Cortex; Disease Models, Animal; Down-Regulation; Estrogens; gamma-Aminobutyric Acid; Glutamic Acid; Infarction, Middle Cerebral Artery; Male; Nerve Degeneration; Neural Inhibition; Neurons; Neuroprotective Agents; Neurotoxins; Rats; Rats, Sprague-Dawley; Sympathetic Nervous System; Up-Regulation

2004
Administration of a non-NMDA antagonist, GYKI 52466, increases excitotoxic Purkinje cell degeneration caused by ibogaine.
    Neuroscience, 2004, Volume: 127, Issue:2

    Topics: Animals; Benzodiazepines; Dose-Response Relationship, Drug; Drug Synergism; Excitatory Amino Acid Antagonists; Glutamic Acid; Ibogaine; Male; Nerve Degeneration; Neurotoxins; Olivary Nucleus; Purkinje Cells; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Synapses; Synaptic Transmission; Up-Regulation

2004
In vivo neuroprotective adaptation of the glutamate/glutamine cycle to neuronal death.
    Hippocampus, 2004, Volume: 14, Issue:5

    Topics: Animals; Apoptosis; Brain; Brain Injuries; Cell Death; Cell Survival; Denervation; Disease Models, Animal; Energy Metabolism; Fornix, Brain; Glutamate-Ammonia Ligase; Glutamic Acid; Glutaminase; Glutamine; Hippocampus; L-Lactate Dehydrogenase; Lactic Acid; Male; Necrosis; Nerve Degeneration; Neurons; Neurotoxins; Rats; Rats, Sprague-Dawley

2004
Neuroprotection in ischemia: blocking calcium-permeable acid-sensing ion channels.
    Cell, 2004, Sep-17, Volume: 118, Issue:6

    Topics: Acid Sensing Ion Channels; Acidosis; Animals; Brain Ischemia; Calcium; Calcium Channel Blockers; Calcium Signaling; Cells, Cultured; COS Cells; Disease Models, Animal; Drug Design; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Degeneration; Nerve Tissue Proteins; Neuroprotective Agents; Rats; Receptors, Glutamate; Sodium Channel Blockers; Sodium Channels

2004
Early loss of the glutamate transporter splice-variant GLT-1v in rat cerebral cortex following lateral fluid-percussion injury.
    Glia, 2005, Jan-01, Volume: 49, Issue:1

    Topics: Alternative Splicing; Amino Acid Transport System X-AG; Animals; Brain Injuries; Carrier Proteins; Cerebral Cortex; Disease Models, Animal; Down-Regulation; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Excitatory Amino Acid Transporter 3; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Hippocampus; Immunohistochemistry; Intermediate Filament Proteins; Male; Nerve Degeneration; Neurons; Protein Isoforms; Rats; Rats, Sprague-Dawley; Symporters; Thalamus; Time Factors; Wounds, Nonpenetrating

2005
Glycine-induced neurotoxicity in organotypic hippocampal slice cultures.
    Experimental brain research, 2005, Volume: 161, Issue:3

    Topics: Alanine; Animals; Animals, Newborn; Brain Ischemia; Dose-Response Relationship, Drug; Drug Resistance; Glutamic Acid; Glycine; Hippocampus; Kynurenic Acid; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Strychnine; Taurine

2005
Altered membrane physiology in Müller glial cells after transient ischemia of the rat retina.
    Glia, 2005, Apr-01, Volume: 50, Issue:1

    Topics: Animals; Brain Ischemia; Cell Membrane; Cells, Cultured; Down-Regulation; Female; Glutamic Acid; Membrane Potentials; Nerve Degeneration; Neuroglia; Patch-Clamp Techniques; Potassium; Potassium Channels, Inwardly Rectifying; Rats; Rats, Long-Evans; Reperfusion Injury; Retina; Retinal Diseases; Sodium Channels

2005
Minocycline in phenotypic models of Huntington's disease.
    Neurobiology of disease, 2005, Volume: 18, Issue:1

    Topics: Animals; Calpain; Caspases; Cell Death; Cells, Cultured; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Encephalitis; Glutamic Acid; Huntingtin Protein; Huntington Disease; Male; Minocycline; Nerve Degeneration; Nerve Tissue Proteins; Neuroprotective Agents; Nitro Compounds; Nuclear Proteins; Phenotype; Propionates; Quinolinic Acid; Rats; Rats, Inbred Lew; Rats, Wistar; Staurosporine

2005
Organotypic brain slice cultures: an efficient and reliable method for neurotoxicological screening and mechanistic studies.
    Alternatives to laboratory animals : ATLA, 2004, Volume: 32, Issue:4

    Topics: Animal Testing Alternatives; Animals; Brain; Cell Death; Glutamic Acid; Hippocampus; Kainic Acid; Microscopy, Fluorescence; Nerve Degeneration; Neurons; Neurotoxins; Organ Culture Techniques; Propidium; Rats; Rats, Wistar; Toxicity Tests

2004
Schwann cells exhibit excitotoxicity consistent with release of NMDA receptor agonists.
    Journal of neuroscience research, 2005, Mar-01, Volume: 79, Issue:5

    Topics: 2-Amino-5-phosphonovalerate; Analysis of Variance; Animals; Calcium; Cell Death; Cells, Cultured; Culture Media, Conditioned; D-Amino-Acid Oxidase; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; Excitatory Amino Acid Antagonists; Fluorescent Antibody Technique; Glutamic Acid; Hippocampus; Kynurenic Acid; Microtubule-Associated Proteins; Nerve Degeneration; Neurons; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Schwann Cells; Tetrazolium Salts; Thiazoles; Time Factors

2005
The activation of spinal N-methyl-D-aspartate receptors may contribute to degeneration of spinal motor neurons induced by neuraxial morphine after a noninjurious interval of spinal cord ischemia.
    Anesthesia and analgesia, 2005, Volume: 100, Issue:2

    Topics: Analgesics, Opioid; Animals; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Injections, Spinal; Male; Morphine; Motor Neurons; Nerve Degeneration; Neuroprotective Agents; Paraparesis; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Spinal Cord Ischemia

2005
Proton MR spectroscopy detected glutamate/glutamine is increased in children with traumatic brain injury.
    Journal of neurotrauma, 2004, Volume: 21, Issue:11

    Topics: Adolescent; Age Factors; Aspartic Acid; Brain; Brain Injuries; Child; Child, Preschool; Choline; Coma; Disease Progression; Female; Glutamic Acid; Glutamine; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Nerve Degeneration; Occipital Lobe; Parietal Lobe; Predictive Value of Tests; Recovery of Function; Up-Regulation

2004
Neuroprotection afforded by prior citicoline administration in experimental brain ischemia: effects on glutamate transport.
    Neurobiology of disease, 2005, Volume: 18, Issue:2

    Topics: Adenosine Triphosphate; Amino Acid Transport System X-AG; Animals; Animals, Newborn; Astrocytes; Biological Transport; Brain; Brain Ischemia; Cell Survival; Cells, Cultured; Cerebral Infarction; Coculture Techniques; Cytidine Diphosphate Choline; Cytoprotection; Disease Models, Animal; Excitatory Amino Acid Transporter 2; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; L-Lactate Dehydrogenase; Male; Nerve Degeneration; Neurons; Neuroprotective Agents; Rats; Rats, Inbred F344; Rats, Wistar; Symporters

2005
Disturbed Ca2+ signaling and apoptosis of medium spiny neurons in Huntington's disease.
    Proceedings of the National Academy of Sciences of the United States of America, 2005, Feb-15, Volume: 102, Issue:7

    Topics: Animals; Apoptosis; Calcium Signaling; Chromosomes, Artificial, Bacterial; Disease Models, Animal; Glutamic Acid; Humans; Huntington Disease; In Vitro Techniques; Mice; Mice, Transgenic; Models, Neurological; Nerve Degeneration; Neurons

2005
TNF alpha potentiates glutamate neurotoxicity by inhibiting glutamate uptake in organotypic brain slice cultures: neuroprotection by NF kappa B inhibition.
    Brain research, 2005, Feb-09, Volume: 1034, Issue:1-2

    Topics: Active Transport, Cell Nucleus; Amino Acid Transport System X-AG; Animals; Animals, Newborn; Antioxidants; Cell Death; Dentate Gyrus; Dose-Response Relationship, Drug; Drug Synergism; Encephalitis; Entorhinal Cortex; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Nerve Degeneration; Neurotoxins; NF-kappa B; Organ Culture Techniques; Rats; Synaptic Transmission; Transcription Factor RelA; Tumor Necrosis Factor-alpha

2005
Protection by cholesterol-extracting cyclodextrins: a role for N-methyl-D-aspartate receptor redistribution.
    Journal of neurochemistry, 2005, Volume: 92, Issue:6

    Topics: Animals; Calcium; Calcium Signaling; Cells, Cultured; Cholesterol; Cyclodextrins; Cytoprotection; Disks Large Homolog 4 Protein; Excitatory Amino Acid Antagonists; Glutamic Acid; Hypoxia-Ischemia, Brain; Intracellular Signaling Peptides and Proteins; Membrane Microdomains; Membrane Proteins; Methylation; N-Methylaspartate; Nerve Degeneration; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Neurotoxins; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Rats; Receptor Aggregation; Receptors, N-Methyl-D-Aspartate; Sulfur Compounds; Synaptic Transmission

2005
Effect of ebselen and organochalcogenides on excitotoxicity induced by glutamate in isolated chick retina.
    Brain research, 2005, Mar-28, Volume: 1039, Issue:1-2

    Topics: Animals; Azoles; Benzene Derivatives; Calcium; Calcium Channels; Chalcogens; Chick Embryo; Dose-Response Relationship, Drug; Glutamic Acid; Isoindoles; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Organometallic Compounds; Organoselenium Compounds; Retina; Tellurium; Tetrazolium Salts; Thiazoles

2005
The mode of spinal motor neurons degeneration in a model of slow glutamate excitotoxicity in vitro.
    Folia neuropathologica, 2005, Volume: 43, Issue:1

    Topics: Animals; Biological Transport; Cell Death; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Microscopy, Electron, Transmission; Motor Neurons; Nerve Degeneration; Neurotoxins; Organ Culture Techniques; Rats; Spinal Cord

2005
Ebselen prevents noise-induced excitotoxicity and temporary threshold shift.
    Neuroscience letters, 2005, Jun-03, Volume: 380, Issue:3

    Topics: Animals; Auditory Threshold; Azoles; Cochlear Nerve; Dendrites; Disease Models, Animal; Evoked Potentials, Auditory, Brain Stem; Excitatory Amino Acid Antagonists; Free Radical Scavengers; Free Radicals; Glutamic Acid; Guinea Pigs; Hair Cells, Auditory; Hearing Loss, Sensorineural; Isoindoles; Male; Nerve Degeneration; Neurons, Afferent; Neuroprotective Agents; Noise; Organoselenium Compounds; Oxidative Stress; Synaptic Transmission; Treatment Outcome

2005
Kanamycin ototoxicity in glutamate transporter knockout mice.
    Neuroscience letters, 2005, Jun-03, Volume: 380, Issue:3

    Topics: Amino Acid Transport System X-AG; Animals; Auditory Threshold; Evoked Potentials, Auditory, Brain Stem; Glutamic Acid; Hair Cells, Auditory, Inner; Hearing Loss, Sensorineural; Kanamycin; Mice; Mice, Knockout; Nerve Degeneration; Neurotoxins; Synaptic Transmission

2005
Dietary restriction affects striatal glutamate in the MPTP-induced mouse model of nigrostriatal degeneration.
    Synapse (New York, N.Y.), 2005, Volume: 57, Issue:2

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Caloric Restriction; Corpus Striatum; Disease Models, Animal; Dopamine; Down-Regulation; Excitatory Amino Acid Transporter 2; Extracellular Fluid; Food Deprivation; Glutamic Acid; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Microdialysis; Microscopy, Electron, Transmission; Nerve Degeneration; Neural Pathways; Parkinsonian Disorders; Presynaptic Terminals; Substantia Nigra; Synaptic Transmission; Tyrosine 3-Monooxygenase

2005
Experimental subarachnoid hemorrhage induces changes in the levels of hippocampal NMDA receptor subunit mRNA.
    Brain research. Molecular brain research, 2005, Jun-13, Volume: 137, Issue:1-2

    Topics: Animals; Cell Death; Cell Survival; Cerebrovascular Circulation; Disease Models, Animal; Down-Regulation; Glutamic Acid; Hippocampus; Male; Nerve Degeneration; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Subarachnoid Hemorrhage; Time Factors

2005
Increased calbindin-D28k immunoreactivity in striatal projection neurons of R6/2 Huntington's disease transgenic mice.
    Neurobiology of disease, 2005, Volume: 20, Issue:3

    Topics: Animals; Calbindin 1; Calbindins; Calcium Signaling; Disease Models, Animal; Excitatory Amino Acid Agonists; Female; Glutamic Acid; Humans; Huntingtin Protein; Huntington Disease; Immunohistochemistry; Male; Mice; Mice, Transgenic; Mutation; Neostriatum; Nerve Degeneration; Nerve Tissue Proteins; Neurons; Neurotoxins; Nuclear Proteins; RNA, Messenger; S100 Calcium Binding Protein G; Trinucleotide Repeat Expansion; Up-Regulation

2005
Dopaminergic neurotoxins require excitotoxic stimulation in organotypic cultures.
    Neurobiology of disease, 2005, Volume: 20, Issue:3

    Topics: 1-Methyl-4-phenylpyridinium; Animals; Animals, Newborn; Brain; Cell Death; Cell Nucleus; Cerebral Cortex; Corpus Striatum; Dopamine; Drug Synergism; Glutamic Acid; N-Methylaspartate; Nerve Degeneration; Neurons; Neurotoxins; Organ Culture Techniques; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; Rotenone; Substantia Nigra; Tyrosine 3-Monooxygenase

2005
ATP-sensitive potassium channel opener iptakalim protected against the cytotoxicity of MPP+ on SH-SY5Y cells by decreasing extracellular glutamate level.
    Journal of neurochemistry, 2005, Volume: 94, Issue:6

    Topics: 1-Methyl-4-phenylpyridinium; Amino Acid Transport System X-AG; ATP-Binding Cassette Transporters; Cell Line, Tumor; Cytoprotection; Down-Regulation; Extracellular Fluid; Glutamic Acid; Humans; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Parkinson Disease; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Inwardly Rectifying; Propylamines; Receptors, Drug; RNA, Messenger; Sulfonylurea Receptors

2005
Modulator effects of interleukin-1beta and tumor necrosis factor-alpha on AMPA-induced excitotoxicity in mouse organotypic hippocampal slice cultures.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005, Jul-20, Volume: 25, Issue:29

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cell Death; Cell Survival; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Glutamic Acid; Hippocampus; Interleukin-1; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Nerve Degeneration; Neurons; Neurotoxins; Organ Culture Techniques; Receptors, AMPA; Receptors, Tumor Necrosis Factor, Type I; Receptors, Tumor Necrosis Factor, Type II; Tumor Necrosis Factor-alpha

2005
The effect of clonidine on cell survival, glutamate, and aspartate release in normo- and hyperglycemic rats after near complete forebrain ischemia.
    Experimental brain research, 2005, Volume: 167, Issue:4

    Topics: Adrenergic alpha-Agonists; Animals; Aspartic Acid; Blood Glucose; Blood Pressure; Brain Chemistry; Brain Ischemia; Cell Death; Cell Survival; Chromatography, High Pressure Liquid; Clonidine; Glutamic Acid; Heart Rate; Hyperglycemia; Lactic Acid; Male; Nerve Degeneration; Prosencephalon; Rats; Rats, Sprague-Dawley; Visual Fields

2005
Zinc causes loss of membrane potential and elevates reactive oxygen species in rat brain mitochondria.
    Mitochondrion, 2005, Volume: 5, Issue:1

    Topics: Animals; Brain; Calcium Channels; Chelating Agents; Egtazic Acid; Electron Transport; Glutamic Acid; Glycerophosphates; In Vitro Techniques; Malates; Membrane Potentials; Mitochondria; Models, Neurological; Nerve Degeneration; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Succinic Acid; Zinc

2005
Increased expression and function of glutamate transporters in multiple sclerosis.
    Neurobiology of disease, 2006, Volume: 21, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Astrocytes; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Excitatory Amino Acid Transporter 3; Female; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Humans; Male; Middle Aged; Multiple Sclerosis; Nerve Degeneration; Neurotoxins; Oligodendroglia; Oligonucleotide Array Sequence Analysis; Optic Nerve; RNA, Messenger

2006
Effect of overexpression of wild-type or mutant parkin on the cellular response induced by toxic insults.
    Journal of neuroscience research, 2005, Oct-15, Volume: 82, Issue:2

    Topics: 1-Methyl-4-phenylpyridinium; Acetylcysteine; Aldehydes; Apoptosis; Cell Death; Cell Line, Tumor; Drug Resistance; Enzyme Inhibitors; Genetic Predisposition to Disease; Glutamic Acid; Guanine; Humans; Hydrogen Peroxide; Mutation; Nerve Degeneration; Neurons; Neurotoxins; Oxidative Stress; Parkinsonian Disorders; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Substantia Nigra; Tyrosine; Ubiquitin-Protein Ligases

2005
Distinct nuclear factor-kappaB/Rel proteins have opposing modulatory effects in glutamate-induced cell death in HT22 cells.
    Neurochemistry international, 2005, Volume: 47, Issue:8

    Topics: Amino Acid Transport System y+; Animals; Aspirin; Cell Death; Cell Line, Transformed; Cell Survival; Cyclooxygenase Inhibitors; Cystine; Glutamic Acid; I-kappa B Proteins; Mice; Nerve Degeneration; Neurons; NF-kappa B; NF-kappa B p50 Subunit; Oligonucleotides, Antisense; Oxidative Stress; Proto-Oncogene Proteins c-rel; Transcription Factor RelA

2005
Knockdown of glutamate-cysteine ligase by small hairpin RNA reveals that both catalytic and modulatory subunits are essential for the survival of primary neurons.
    The Journal of biological chemistry, 2005, Nov-25, Volume: 280, Issue:47

    Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Survival; Cells, Cultured; Glutamate-Cysteine Ligase; Glutamic Acid; Humans; Nerve Degeneration; Neurons; Nitric Oxide; Protein Subunits; Rats; RNA Interference; RNA, Small Interfering

2005
Ischemic preconditioning ameliorates excitotoxicity by shifting glutamate/gamma-aminobutyric acid release and biosynthesis.
    Journal of neuroscience research, 2005, Dec-01, Volume: 82, Issue:5

    Topics: Animals; Brain Ischemia; Cell Death; Disease Models, Animal; Extracellular Fluid; GABA Agonists; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamic Acid; Hippocampus; Ischemic Preconditioning; Male; Nerve Degeneration; Neurotoxins; Organ Culture Techniques; Presynaptic Terminals; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, GABA-B

2005
Late N-methyl-D-aspartate receptor blockade rescues hippocampal neurons from excitotoxic stress and death after 4-aminopyridine-induced epilepsy.
    The European journal of neuroscience, 2005, Volume: 22, Issue:12

    Topics: 4-Aminopyridine; Animals; Cell Count; Cell Death; Chelating Agents; Disease Models, Animal; Dizocilpine Maleate; Drug Interactions; Egtazic Acid; Electroencephalography; Epilepsy; Excitatory Amino Acid Antagonists; Functional Laterality; Glutamic Acid; Hippocampus; Male; Microdialysis; Nerve Degeneration; Neurons; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Stress, Physiological; Time Factors

2005
Early, transient increase in complexin I and complexin II in the cerebral cortex following traumatic brain injury is attenuated by N-acetylcysteine.
    Journal of neurotrauma, 2006, Volume: 23, Issue:1

    Topics: Acetylcysteine; Adaptor Proteins, Vesicular Transport; Animals; Brain Injuries; Cerebral Cortex; Disease Models, Animal; Free Radical Scavengers; Glutamic Acid; Hippocampus; Male; Nerve Degeneration; Nerve Tissue Proteins; Neurotoxins; Oxidative Stress; Rats; Rats, Sprague-Dawley; SNARE Proteins; Synaptic Membranes; Synaptic Transmission; Time Factors; Up-Regulation

2006
Mechanisms of neurodegeneration in neuronal ceroid-lipofuscinoses.
    Acta neuropathologica, 2006, Volume: 111, Issue:2

    Topics: Adolescent; Adult; Apoptosis; Calcium-Binding Proteins; Child; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Female; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Humans; Male; Nerve Degeneration; Neuroglia; Neuronal Ceroid-Lipofuscinoses; Neurotoxins; Oxidative Stress

2006
A sensitive and selective assay of neuronal degeneration in cell culture.
    Journal of neuroscience methods, 2006, Jun-30, Volume: 154, Issue:1-2

    Topics: Animals; Antioxidants; Biological Assay; Cell Death; Cell Survival; Cells, Cultured; Coculture Techniques; Excitatory Amino Acids; Fluorescent Antibody Technique; Glial Fibrillary Acidic Protein; Glutamic Acid; Hydrogen Peroxide; L-Lactate Dehydrogenase; Male; Mice; Microtubule-Associated Proteins; Nerve Degeneration; Neuroglia; Neuroprotective Agents; Oxazines; Oxidants

2006
Clinical correlates of quantitative EEG alterations in alcoholic patients.
    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2006, Volume: 117, Issue:4

    Topics: Adult; Age Factors; Aged; Alcohol Withdrawal Seizures; Alcohol-Induced Disorders, Nervous System; Alcoholism; Atrophy; Benzodiazepines; Brain Damage, Chronic; Central Nervous System Depressants; Cerebral Cortex; Drug Interactions; Electroencephalography; Ethanol; gamma-Aminobutyric Acid; Genetic Predisposition to Disease; Glutamic Acid; Hallucinations; Humans; Male; Middle Aged; Models, Neurological; Nerve Degeneration; Neurotoxins

2006
Interferon-gamma is up-regulated in the hippocampus in response to intermittent fasting and protects hippocampal neurons against excitotoxicity.
    Journal of neuroscience research, 2006, Volume: 83, Issue:8

    Topics: Animals; Calcium; Caloric Restriction; Cells, Cultured; Cytoprotection; Disease Models, Animal; Excitatory Amino Acid Antagonists; Food, Formulated; Glutamic Acid; Hippocampus; Interferon gamma Receptor; Interferon-gamma; Male; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, Interferon; Stress, Physiological; Up-Regulation

2006
Involvement of calmodulin in neuronal cell death.
    Brain research, 2006, Apr-14, Volume: 1083, Issue:1

    Topics: Animals; Binding Sites; Brain; Brain Ischemia; Calcium; Calcium Signaling; Calmodulin; Cell Death; Cells, Cultured; Cerebral Infarction; Cytoprotection; Glutamic Acid; Humans; Membrane Potentials; Mutation; Nerve Degeneration; Neurotoxins; Potassium Chloride; Rats; Rats, Wistar; Transfection

2006
System Xc- and apolipoprotein E expressed by microglia have opposite effects on the neurotoxicity of amyloid-beta peptide 1-40.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006, Mar-22, Volume: 26, Issue:12

    Topics: Alzheimer Disease; Amino Acid Transport System y+; Amyloid beta-Peptides; Animals; Apolipoproteins E; Cell Communication; Cell Death; Cell Survival; Cells, Cultured; Coculture Techniques; Female; Gene Expression Regulation; Glutamic Acid; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Microglia; Nerve Degeneration; Neurons; Peptide Fragments; Rats; Rats, Wistar

2006
NAAG peptidase inhibitor increases dialysate NAAG and reduces glutamate, aspartate and GABA levels in the dorsal hippocampus following fluid percussion injury in the rat.
    Journal of neurochemistry, 2006, Volume: 97, Issue:4

    Topics: Animals; Aspartic Acid; Brain Injuries; Cytoprotection; Dipeptides; Disease Models, Animal; Down-Regulation; Enzyme Inhibitors; Extracellular Fluid; gamma-Aminobutyric Acid; Glutamate Carboxypeptidase II; Glutamic Acid; Hippocampus; Male; Microdialysis; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Up-Regulation

2006
Cyclopentenone isoprostanes are novel bioactive products of lipid oxidation which enhance neurodegeneration.
    Journal of neurochemistry, 2006, Volume: 97, Issue:5

    Topics: Adaptor Proteins, Signal Transducing; Animals; Arachidonate 12-Lipoxygenase; Cells, Cultured; Cyclopentanes; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glutamic Acid; Glutathione; Isoprostanes; Lipid Peroxidation; Mitogen-Activated Protein Kinase 3; Models, Neurological; Molecular Structure; Nerve Degeneration; Neurons; Oxidative Stress; Phosphorylation; Prostaglandins A; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1

2006
Glutamate transporters GLAST and EAAT4 regulate postischemic Purkinje cell death: an in vivo study using a cardiac arrest model in mice lacking GLAST or EAAT4.
    Neuroscience research, 2006, Volume: 55, Issue:3

    Topics: Animals; Brain Infarction; Cell Death; Disease Models, Animal; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 4; Glutamic Acid; Heart Arrest; Heart Arrest, Induced; Hypoxia-Ischemia, Brain; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Purkinje Cells

2006
Glutamate-induced apoptosis in neuronal cells is mediated via caspase-dependent and independent mechanisms involving calpain and caspase-3 proteases as well as apoptosis inducing factor (AIF) and this process is inhibited by equine estrogens.
    BMC neuroscience, 2006, Jun-15, Volume: 7

    Topics: Animals; Apoptosis; Apoptosis Inducing Factor; Calpain; Caspase 3; Caspase Inhibitors; Caspases; Cell Line; Cells, Cultured; Estradiol; Estrogens; Glutamic Acid; Horses; Mice; Nerve Degeneration; Neurons; Neuroprotective Agents; Protein Transport; Rats; Signal Transduction; Up-Regulation

2006
Miniature synaptic currents become neurotoxic to chronically silenced neurons.
    Cerebral cortex (New York, N.Y. : 1991), 2007, Volume: 17, Issue:6

    Topics: Action Potentials; Anesthetics, Local; Animals; Apoptosis; Calcium; Cells, Cultured; Dendritic Spines; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Nerve Degeneration; Neurons; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Synaptic Transmission; Tetrodotoxin

2007
A novel organotypic culture model of the postnatal mouse retina allows the study of glutamate-mediated excitotoxicity.
    Journal of neuroscience methods, 2007, Jan-15, Volume: 159, Issue:1

    Topics: Animals; Apoptosis; Culture Media; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glutamic Acid; Immunohistochemistry; In Situ Nick-End Labeling; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence; Models, Neurological; N-Methylaspartate; Nerve Degeneration; Organ Culture Techniques; Retina; Retinal Ganglion Cells

2007
3-Nitropropionic acid toxicity in hippocampus: protection through N-methyl-D-aspartate receptor antagonism.
    Hippocampus, 2006, Volume: 16, Issue:10

    Topics: Animals; Animals, Newborn; Cytoskeleton; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Memantine; Mitochondria; Nerve Degeneration; Neural Pathways; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Neurotoxins; Nitro Compounds; Organ Culture Techniques; Propionates; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission

2006
Erythropoietin is neuroprotective against NMDA-receptor-mediated excitotoxic brain injury in newborn mice.
    Neurobiology of disease, 2006, Volume: 24, Issue:2

    Topics: Animals; Animals, Newborn; Brain; Cytoprotection; Disease Models, Animal; Drug Administration Schedule; Erythropoietin; Female; Glutamic Acid; Humans; Ibotenic Acid; Infant, Newborn; Injections, Intraventricular; Leukomalacia, Periventricular; Male; Mice; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Receptors, Erythropoietin; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Time Factors

2006
Dissociation between hippocampal neuronal loss, astroglial and microglial reactivity after pharmacologically induced reverse glutamate transport.
    Neurochemistry international, 2006, Volume: 49, Issue:7

    Topics: Amino Acid Transport System X-AG; Animals; Astrocytes; Calcium; Calcium Signaling; Cell Death; Dicarboxylic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Encephalitis; Gliosis; Glutamic Acid; Hippocampus; Male; Microglia; Nerve Degeneration; Neuroglia; Neurons; Neurotransmitter Uptake Inhibitors; Pyrrolidines; Rats; Rats, Wistar

2006
Brain neuroprotection by scavenging blood glutamate.
    Experimental neurology, 2007, Volume: 203, Issue:1

    Topics: Animals; Aspartate Aminotransferase, Cytoplasmic; Brain; Brain Injuries; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Drug Synergism; Glutamic Acid; Injections, Intravenous; Male; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Oxaloacetic Acid; Rats; Rats, Sprague-Dawley; Recovery of Function; Treatment Outcome

2007
Astroglial alterations in amyotrophic lateral sclerosis (ALS) model of slow glutamate excitotoxicity in vitro.
    Folia neuropathologica, 2006, Volume: 44, Issue:3

    Topics: Amyotrophic Lateral Sclerosis; Animals; Astrocytes; Disease Models, Animal; Excitatory Amino Acid Antagonists; Glutamic Acid; Microscopy, Electron, Transmission; Motor Neurons; Nerve Degeneration; Organ Culture Techniques; Rats; Spinal Cord

2006
The HSV-2 protein ICP10PK prevents neuronal apoptosis and loss of function in an in vivo model of neurodegeneration associated with glutamate excitotoxicity.
    Experimental neurology, 2007, Volume: 203, Issue:2

    Topics: Animals; Apomorphine; Apoptosis; Behavior, Animal; Chlorocebus aethiops; Coloring Agents; Dopamine Agonists; Electron Transport Complex IV; Excitatory Amino Acids; Glutamic Acid; Immunohistochemistry; In Situ Nick-End Labeling; Indicators and Reagents; Injections; Male; Mice; Mitogen-Activated Protein Kinase Kinases; N-Methylaspartate; Neostriatum; Nerve Degeneration; Neurons; Neuroprotective Agents; Phenothiazines; Protein Serine-Threonine Kinases; Ribonucleotide Reductases; Vero Cells

2007
Nrf2 gene deletion fails to alter psychostimulant-induced behavior or neurotoxicity.
    Brain research, 2007, Jan-05, Volume: 1127, Issue:1

    Topics: Amino Acid Transport System y+; Animals; Brain; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine; Dopamine Uptake Inhibitors; Gene Expression Regulation; Glutamic Acid; Methamphetamine; Mice; Mice, Knockout; Nerve Degeneration; NF-E2-Related Factor 2; Nucleus Accumbens; Oxidative Stress; Regulatory Elements, Transcriptional

2007
Mouse galectin-1 inhibits the toxicity of glutamate by modifying NR1 NMDA receptor expression.
    The European journal of neuroscience, 2006, Volume: 24, Issue:11

    Topics: Animals; Astrocytes; Cell Death; Cells, Cultured; Cerebellar Cortex; Coculture Techniques; Galectin 1; Glutamic Acid; Mice; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Oligodeoxyribonucleotides, Antisense; Protein Kinase C; Protein Structure, Tertiary; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Up-Regulation

2006
Glutamate-mediated excitotoxicity in neonatal hippocampal neurons is mediated by mGluR-induced release of Ca++ from intracellular stores and is prevented by estradiol.
    The European journal of neuroscience, 2006, Volume: 24, Issue:11

    Topics: Animals; Asphyxia Neonatorum; Calcium; Calcium Signaling; Cell Death; Cells, Cultured; Disease Models, Animal; Down-Regulation; Estradiol; Female; Glutamic Acid; Hippocampus; Humans; Hypoxia-Ischemia, Brain; Infant, Newborn; Intracellular Fluid; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate

2006
The direct and indirect effects of serofendic acid on neuroprotection.
    Annals of the New York Academy of Sciences, 2006, Volume: 1086

    Topics: Animals; Astrocytes; Cell Survival; Cells, Cultured; Cytokines; Diterpenes; Glutamic Acid; Mice; Mice, Inbred C57BL; N-Methylaspartate; Nerve Degeneration; Nerve Growth Factors; Neuroglia; Neurons; Neuroprotective Agents

2006
NMDA receptor-mediated excitotoxicity contributes to the cerebral hypoxic injury of a rat model of posthypoxic myoclonus.
    Brain research, 2007, Feb-16, Volume: 1133, Issue:1

    Topics: Animals; Brain Damage, Chronic; Cerebellum; Disease Models, Animal; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Hypoxia, Brain; Intralaminar Thalamic Nuclei; Male; Memantine; Myoclonus; Nerve Degeneration; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission

2007
Stretch-induced injury in organotypic hippocampal slice cultures reproduces in vivo post-traumatic neurodegeneration: role of glutamate receptors and voltage-dependent calcium channels.
    Journal of neurochemistry, 2007, Volume: 101, Issue:2

    Topics: Animals; Brain Injuries; Calcium Channel Blockers; Calcium Channels; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; Membranes, Artificial; Microtubule-Associated Proteins; Models, Neurological; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Organ Culture Techniques; Physical Stimulation; Rats; Receptors, Glutamate; Silicones; Stress, Mechanical; Synaptic Transmission

2007
An acute dysfunction of the glutamate transport activity has been shown to generate free radicals and suppress the anti-oxidant ability in the hippocampus of rats.
    Neuroscience research, 2007, Volume: 57, Issue:3

    Topics: Amino Acid Transport System X-AG; Animals; Dicarboxylic Acids; Enzyme Inhibitors; Free Radical Scavengers; Free Radicals; Glutamic Acid; Hippocampus; Lipids; Male; Nerve Degeneration; Neurotoxins; Oxidation-Reduction; Oxidative Stress; Pyrrolidines; Rats; Rats, Wistar; Spin Trapping

2007
Melatonin prevents glutamate-induced oxytosis in the HT22 mouse hippocampal cell line through an antioxidant effect specifically targeting mitochondria.
    Journal of neurochemistry, 2007, Volume: 100, Issue:3

    Topics: Animals; Antioxidants; Cell Death; Cell Line; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Glutathione; Hippocampus; Melatonin; Mice; Microscopy, Electron, Transmission; Mitochondria; Nerve Degeneration; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Oxidative Stress; Reactive Oxygen Species; Signal Transduction

2007
Activation of the galanin receptor 2 (GalR2) protects the hippocampus from neuronal damage.
    Journal of neurochemistry, 2007, Volume: 100, Issue:3

    Topics: Animals; Brain Damage, Chronic; Cytoprotection; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Galanin; Glutamic Acid; Hippocampus; Male; Mice; Mice, Knockout; Nerve Degeneration; Neurodegenerative Diseases; Neurons; Organ Culture Techniques; Proto-Oncogene Proteins c-akt; Receptor, Galanin, Type 2; Signal Transduction; Up-Regulation

2007
Simultaneous age-related depolarization of mitochondrial membrane potential and increased mitochondrial reactive oxygen species production correlate with age-related glutamate excitotoxicity in rat hippocampal neurons.
    Journal of neuroscience research, 2007, Volume: 85, Issue:5

    Topics: Aging; Animals; Cells, Cultured; Cellular Senescence; Glutamic Acid; Hippocampus; Membrane Potential, Mitochondrial; Nerve Degeneration; Neurodegenerative Diseases; Neurons; Neurotoxins; Oxidative Phosphorylation; Oxidative Stress; Rats; Rats, Inbred F344; Reactive Oxygen Species

2007
Functional role of mGluR1 and mGluR4 in pilocarpine-induced temporal lobe epilepsy.
    Neurobiology of disease, 2007, Volume: 26, Issue:3

    Topics: Animals; Convulsants; Disease Models, Animal; Down-Regulation; Epilepsy; Epilepsy, Temporal Lobe; Gene Expression Regulation; Genetic Predisposition to Disease; Glutamic Acid; Green Fluorescent Proteins; Hippocampus; Mice; Mice, Knockout; Mice, Transgenic; Nerve Degeneration; Neurons; Pilocarpine; Receptors, Metabotropic Glutamate; Recombinant Fusion Proteins; Up-Regulation

2007
NP031112, a thiadiazolidinone compound, prevents inflammation and neurodegeneration under excitotoxic conditions: potential therapeutic role in brain disorders.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007, May-23, Volume: 27, Issue:21

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain Diseases; Brain Edema; Cell Death; Cells, Cultured; Excitatory Amino Acid Agents; Glutamic Acid; Inflammation; Male; Nerve Degeneration; Neuroprotective Agents; Rats; Rats, Wistar; Thiadiazoles

2007
3,4-dihydroxybenzoic acid from Smilacis chinae rhizome protects amyloid beta protein (25-35)-induced neurotoxicity in cultured rat cortical neurons.
    Neuroscience letters, 2007, Jun-13, Volume: 420, Issue:2

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Calcium; Calcium Signaling; Caspase 3; Caspase Inhibitors; Cell Survival; Cells, Cultured; Cerebral Cortex; Cytoprotection; Glutamic Acid; Hydroxybenzoates; Indicators and Reagents; Maianthemum; Nerve Degeneration; Neurons; Neuroprotective Agents; Peptide Fragments; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species

2007
COX-2 oxidative metabolite of endocannabinoid 2-AG enhances excitatory glutamatergic synaptic transmission and induces neurotoxicity.
    Journal of neurochemistry, 2007, Volume: 102, Issue:6

    Topics: Animals; Apoptosis; Arachidonic Acids; Brain; Caspase 3; Cells, Cultured; Cyclooxygenase 2; Dinoprostone; Encephalitis; Endocannabinoids; Excitatory Postsynaptic Potentials; Glutamic Acid; Glycerides; Mice; Nerve Degeneration; Neurotoxins; Patch-Clamp Techniques; Phosphorylation; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Signal Transduction; Synaptic Transmission

2007
EphB1 null mice exhibit neuronal loss in substantia nigra pars reticulata and spontaneous locomotor hyperactivity.
    The European journal of neuroscience, 2007, Volume: 25, Issue:9

    Topics: Animals; Basal Ganglia Diseases; beta-Galactosidase; Biomarkers; Cell Death; Cell Differentiation; Corpus Striatum; Dopamine; gamma-Aminobutyric Acid; Genes, Reporter; Glutamic Acid; Hyperkinesis; Mice; Mice, Knockout; Models, Neurological; Nerve Degeneration; Nervous System Malformations; Neural Pathways; Presynaptic Terminals; Receptor, EphB1; Substantia Nigra; Tyrosine 3-Monooxygenase

2007
Reperfusion accelerates acute neuronal death induced by simulated ischemia.
    Experimental neurology, 2007, Volume: 206, Issue:2

    Topics: Acidosis, Respiratory; Animals; Apoptosis; Cell Death; Cell Membrane; Cells, Cultured; Cytoskeleton; Glucose; Glutamic Acid; Hypercapnia; Hypoxia-Ischemia, Brain; Mice; Mice, Inbred C57BL; Necrosis; Nerve Degeneration; Neurons; Neurotoxins; Potassium; Reperfusion Injury; Time Factors

2007
The potential role of glutamate transporters in the pathogenesis of normal tension glaucoma.
    The Journal of clinical investigation, 2007, Volume: 117, Issue:7

    Topics: Amino Acid Transport System X-AG; Animals; Disease Models, Animal; Gene Expression Regulation; Glaucoma; Glutamic Acid; Intraocular Pressure; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutation; Nerve Degeneration; Optic Nerve Diseases; Oxidative Stress; Retinal Ganglion Cells; Vision, Ocular

2007
Neonatal Borna disease virus infection in rats is associated with increased extracellular levels of glutamate and neurodegeneration in the striatum.
    Journal of neurovirology, 2007, Volume: 13, Issue:3

    Topics: Amino Acid Transport System X-AG; Amino Acid Transport Systems; Animals; Animals, Newborn; Astrocytes; Borna Disease; Borna disease virus; Corpus Striatum; Extracellular Space; Female; Gliosis; Glutamic Acid; Microdialysis; Microglia; Nerve Degeneration; Neurons; Neurotoxins; Pregnancy; Rats; Rats, Inbred F344

2007
Dopamine receptor activation reveals a novel, kynurenate-sensitive component of striatal N-methyl-D-aspartate neurotoxicity.
    Neuroscience, 2007, Aug-10, Volume: 148, Issue:1

    Topics: Animals; Astrocytes; Cell Death; Corpus Striatum; Dopamine; Dopamine Agonists; Excitatory Amino Acid Agonists; Female; Glutamic Acid; Humans; Kynurenic Acid; N-Methylaspartate; Nerve Degeneration; Neurotoxins; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, N-Methyl-D-Aspartate

2007
Sphingosylphosphocholine effects on cultured astrocytes reveal mechanisms potentially involved in neurotoxicity in Niemann-Pick type A disease.
    The European journal of neuroscience, 2007, Volume: 26, Issue:4

    Topics: Animals; Apoptosis; Astrocytes; Cell Proliferation; Cells, Cultured; Cerebral Cortex; Fluorescent Dyes; Fura-2; Glutamic Acid; Hippocampus; Microscopy, Video; Necrosis; Nerve Degeneration; Neurotoxicity Syndromes; Niemann-Pick Disease, Type A; Phenotype; Phosphorylcholine; Rats; Rats, Sprague-Dawley; Sphingosine

2007
Canine distemper virus infection of primary hippocampal cells induces increase in extracellular glutamate and neurodegeneration.
    Journal of neurochemistry, 2007, Volume: 103, Issue:3

    Topics: Animals; Animals, Newborn; Astrocytes; Cell Death; Cells, Cultured; Chlorocebus aethiops; Distemper; Distemper Virus, Canine; Excitatory Amino Acid Antagonists; Extracellular Fluid; Gliosis; Glutamic Acid; Green Fluorescent Proteins; Hippocampus; Nerve Degeneration; Neurons; Rats; Receptors, Glutamate; Recombinant Proteins; Up-Regulation; Vero Cells

2007
Subtype selective antagonism of substantia nigra pars compacta Group I metabotropic glutamate receptors protects the nigrostriatal system against 6-hydroxydopamine toxicity in vivo.
    Journal of neurochemistry, 2007, Volume: 103, Issue:3

    Topics: Animals; Benzoates; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Male; Molecular Structure; Nerve Degeneration; Neural Pathways; Neuroprotective Agents; Neurotoxins; Oxidopamine; Parkinsonian Disorders; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Substantia Nigra; Treatment Outcome; Tyrosine 3-Monooxygenase

2007
Abnormal glutamate homeostasis and impaired synaptic plasticity and learning in a mouse model of tuberous sclerosis complex.
    Neurobiology of disease, 2007, Volume: 28, Issue:2

    Topics: Animals; Astrocytes; Brain; Disease Models, Animal; Excitatory Amino Acid Antagonists; Glial Fibrillary Acidic Protein; Glutamic Acid; Hippocampus; Homeostasis; Learning Disabilities; Long-Term Potentiation; Mice; Mice, Knockout; Neocortex; Nerve Degeneration; Neuronal Plasticity; Organ Culture Techniques; Synaptic Transmission; Tuberous Sclerosis; Tuberous Sclerosis Complex 1 Protein; Tumor Suppressor Proteins

2007
Delayed IGF-1 administration rescues oligodendrocyte progenitors from glutamate-induced cell death and hypoxic-ischemic brain damage.
    Developmental neuroscience, 2007, Volume: 29, Issue:4-5

    Topics: Animals; Animals, Newborn; Apoptosis; Caspase 3; Cells, Cultured; Cytoprotection; Drug Administration Schedule; Glutamic Acid; Hypoxia-Ischemia, Brain; Insulin-Like Growth Factor I; Myelin Basic Protein; Nerve Degeneration; Nerve Fibers, Myelinated; Nerve Growth Factors; Neurotoxins; Oligodendroglia; Rats; Rats, Sprague-Dawley; Rats, Wistar; Stem Cells; Time Factors; Treatment Outcome

2007
Spontaneously hypertensive rats are highly vulnerable to AMPA-induced brain lesions.
    Stroke, 2007, Volume: 38, Issue:11

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Blood Pressure; Brain Damage, Chronic; Brain Ischemia; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Death; Genetic Predisposition to Disease; Glutamic Acid; Hypertension; Ion Channel Gating; Male; Membrane Potentials; Nerve Degeneration; Neurotoxins; Phosphorylation; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, AMPA; Regional Blood Flow; Vascular Resistance

2007
The neuroprotective potential of phase II enzyme inducer on motor neuron survival in traumatic spinal cord injury in vitro.
    Cellular and molecular neurobiology, 2008, Volume: 28, Issue:5

    Topics: Animals; Animals, Newborn; Cell Survival; Disease Models, Animal; Enzyme Induction; Enzyme Inhibitors; Glutamic Acid; Heme Oxygenase (Decyclizing); Hydroquinones; Mitochondria; Motor Neurons; Nerve Degeneration; Neuroprotective Agents; NF-E2-Related Factor 2; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; RNA, Messenger; Spinal Cord; Spinal Cord Injuries; Sulfhydryl Compounds; Thiones

2008
NR1 and GluR2 expression mediates excitotoxicity in chronic hypobaric hypoxia.
    Journal of neuroscience research, 2008, Volume: 86, Issue:5

    Topics: Altitude Sickness; Animals; Atmospheric Pressure; Chromatin; Chronic Disease; Disease Models, Animal; Down-Regulation; Excitatory Amino Acid Antagonists; Glutamate Dehydrogenase; Glutamic Acid; Hypoxia, Brain; Male; Maze Learning; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Oxidative Stress; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Up-Regulation

2008
Methamphetamine induces alterations on hippocampal NMDA and AMPA receptor subunit levels and impairs spatial working memory.
    Neuroscience, 2007, Dec-05, Volume: 150, Issue:2

    Topics: Animals; Central Nervous System Stimulants; Fluoresceins; Gliosis; Glutamic Acid; Hippocampus; Male; Maze Learning; Memory Disorders; Memory, Short-Term; Methamphetamine; Nerve Degeneration; Organic Chemicals; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Up-Regulation

2007
alpha-Amino-3-hydroxy-5-methyl-4-isoxazole propionate attenuates glutamate-induced caspase-3 cleavage via regulation of glycogen synthase kinase 3beta.
    Journal of neuroscience research, 2008, Volume: 86, Issue:5

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Brain Ischemia; Caspase 3; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glutamic Acid; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Nerve Degeneration; Neuroprotective Agents; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Receptors, AMPA; Reperfusion Injury; Signal Transduction; Time Factors

2008
Downregulation of glutamate transporters is associated with elevation in extracellular glutamate concentration following rat microsphere embolism.
    Neuroscience letters, 2008, Jan-17, Volume: 430, Issue:3

    Topics: Animals; Brain; Brain Infarction; Brain Ischemia; Disease Models, Animal; Down-Regulation; Excitatory Amino Acid Transporter 2; Excitatory Amino Acid Transporter 3; Extracellular Fluid; Glial Fibrillary Acidic Protein; Glutamic Acid; Intracranial Embolism; Male; Microdialysis; Microspheres; Microtubule-Associated Proteins; Nerve Degeneration; Neuroglia; Neurons; Potassium Chloride; Rats; Rats, Wistar; Up-Regulation

2008
NMDA receptor-mediated excitotoxic neuronal apoptosis in vitro and in vivo occurs in an ER stress and PUMA independent manner.
    Journal of neurochemistry, 2008, Volume: 105, Issue:3

    Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Brain; Brain Ischemia; Calcium Signaling; Endoplasmic Reticulum; Epilepsy; Female; Glutamic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Degeneration; Neurons; Neurotoxins; Organ Culture Techniques; Oxidative Stress; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Tumor Suppressor Proteins; Tunicamycin

2008
HIV-infected macrophages mediate neuronal apoptosis through mitochondrial glutaminase.
    Journal of neurochemistry, 2008, Volume: 105, Issue:3

    Topics: AIDS Dementia Complex; Animals; Apoptosis; Brain; Caspases; Cell Cycle; Cells, Cultured; Culture Media, Conditioned; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glutamic Acid; Glutaminase; Glutamine; Humans; Macrophages; Mitochondria; Monocytes; Nerve Degeneration; Neurons; Neurotoxins; Rats

2008
Neuroprotective effects of an extract from the inflamed skin of rabbits inoculated with vaccinia virus on glutamate-induced neurotoxicity in cultured neuronal cell line.
    Neurological research, 2008, Volume: 30, Issue:4

    Topics: Analgesics; Animals; Cell Death; Cell Extracts; Cell Line, Transformed; Cell Nucleus Shape; Cytoplasm; Dermatitis; Glutamic Acid; Hybridomas; Mice; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Pain, Intractable; Polysaccharides; Rabbits; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Tissue Extracts; Vaccinia virus

2008
Neuroprotective effect caused by MPEP, an antagonist of metabotropic glutamate receptor mGluR5, on seizures induced by pilocarpine in 21-day-old rats.
    Brain research, 2008, Mar-10, Volume: 1198

    Topics: Acetylcholinesterase; Animals; Brain; Convulsants; Cytoprotection; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Muscarinic Agonists; Nerve Degeneration; Neuroprotective Agents; Oxidative Stress; Pilocarpine; Pyridines; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Synaptic Transmission; Treatment Outcome

2008
Altered presymptomatic AMPA and cannabinoid receptor trafficking in motor neurons of ALS model mice: implications for excitotoxicity.
    The European journal of neuroscience, 2008, Volume: 27, Issue:3

    Topics: Amyotrophic Lateral Sclerosis; Animals; Cell Death; Disease Models, Animal; Down-Regulation; Female; Glutamic Acid; Humans; Male; Mice; Mice, Transgenic; Motor Neurons; Nerve Degeneration; Neural Inhibition; Neurotoxins; Protein Transport; Receptor, Cannabinoid, CB1; Receptors, AMPA; Spinal Cord; Synaptic Transmission; Up-Regulation

2008
Ceftriaxone rescues hippocampal neurons from excitotoxicity and enhances memory retrieval in chronic hypobaric hypoxia.
    Neurobiology of learning and memory, 2008, Volume: 89, Issue:4

    Topics: Animals; Anti-Bacterial Agents; Ceftriaxone; Chromatin; Chronic Disease; Excitatory Amino Acid Transporter 2; Glutamic Acid; Glutathione; Hippocampus; Hypoxia, Brain; L-Lactate Dehydrogenase; Lipid Peroxidation; Male; Maze Learning; Memory; Memory Disorders; Nerve Degeneration; Neurons; Neurotoxins; Oxidative Stress; Rats; Rats, Sprague-Dawley; Space Perception

2008
Tetramethylpyrazine inhibits activities of glioma cells and glutamate neuro-excitotoxicity: potential therapeutic application for treatment of gliomas.
    Neuro-oncology, 2008, Volume: 10, Issue:2

    Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Coculture Techniques; Glioma; Glutamic Acid; Microdialysis; Nerve Degeneration; Neurons; Pyrazines; Rats; Rats, Sprague-Dawley; Xenograft Model Antitumor Assays

2008
Glutamate is critically involved in seizure-induced overexpression of P-glycoprotein in the brain.
    Neuropharmacology, 2008, Volume: 54, Issue:6

    Topics: Animals; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain Chemistry; Capillaries; Dizocilpine Maleate; Epilepsy, Temporal Lobe; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Image Processing, Computer-Assisted; Immunohistochemistry; Muscarinic Agonists; Nerve Degeneration; Pilocarpine; Quinolines; Rats; Rats, Wistar; Seizures; Status Epilepticus

2008
Excitatory amino acid transporter expression by astrocytes is neuroprotective against microglial excitotoxicity.
    Brain research, 2008, May-19, Volume: 1210

    Topics: Amino Acid Transport Systems, Acidic; Animals; Astrocytes; Cell Communication; Cells, Cultured; Coculture Techniques; Cytoprotection; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Excitatory Amino Acid Transporter 3; Excitatory Amino Acid Transporter 4; Excitatory Amino Acid Transporter 5; Gliosis; Glutamic Acid; Mice; Mice, Inbred C57BL; Microglia; Nerve Degeneration; Neurotoxins; RNA, Messenger

2008
Myelin-induced microglial neurotoxicity can be controlled by microglial metabotropic glutamate receptors.
    Journal of neurochemistry, 2008, Volume: 106, Issue:1

    Topics: Animals; Cell Communication; Cell Death; Cells, Cultured; Cytoprotection; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Gliosis; Glutamic Acid; Microglia; Myelin Proteins; Myelin Sheath; Nerve Degeneration; Neurotoxins; Nitric Oxide Synthase Type I; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Tumor Necrosis Factor-alpha

2008
Curcumin protects against glutamate excitotoxicity in rat cerebral cortical neurons by increasing brain-derived neurotrophic factor level and activating TrkB.
    Brain research, 2008, May-19, Volume: 1210

    Topics: Animals; Animals, Newborn; Antidepressive Agents; Apoptosis; Brain-Derived Neurotrophic Factor; Carbazoles; Cell Survival; Cells, Cultured; Cerebral Cortex; Curcumin; Depressive Disorder; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; Glutamic Acid; Indole Alkaloids; Nerve Degeneration; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Receptor, trkB; Up-Regulation

2008
Mild mitochondrial inhibition in vivo enhances glutamate-induced neuronal damage through calpain but not caspase activation: role of ionotropic glutamate receptors.
    Experimental neurology, 2008, Volume: 212, Issue:1

    Topics: Animals; Brain Diseases, Metabolic; Calpain; Caspase 3; Cell Death; Enzyme Activation; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Mitochondria; Mitochondrial Diseases; Nerve Degeneration; Neurotoxins; Rats; Rats, Wistar; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Signal Transduction

2008
Effects of spinal transection on presynaptic markers for glutamatergic neurons in the rat.
    Neurochemical research, 1981, Volume: 6, Issue:5

    Topics: Animals; Axons; Glutamates; Glutamic Acid; Kinetics; Male; Nerve Degeneration; Neurons; Rats; Rats, Inbred Strains; Spinal Cord; Synapses; Tritium

1981
Kainic acid neurotoxicity; effect of systemic injection on neurotransmitter markers in different brain regions.
    Brain research, 1981, Dec-28, Volume: 230, Issue:1-2

    Topics: Amygdala; Animals; Brain; Choline O-Acetyltransferase; Corpus Striatum; Glutamate Decarboxylase; Glutamates; Glutamic Acid; Hippocampus; Injections, Subcutaneous; Kainic Acid; Male; Nerve Degeneration; Neurons; Neurotransmitter Agents; Pyrrolidines; Rats; Rats, Inbred Strains; Septum Pellucidum; Thalamus

1981
Abnormal glutamate metabolism in an adult-onset degenerative neurological disorder.
    Science (New York, N.Y.), 1982, Apr-09, Volume: 216, Issue:4542

    Topics: Glutamate Dehydrogenase; Glutamates; Glutamic Acid; Humans; Ketoglutaric Acids; Nerve Degeneration; Nervous System Diseases

1982
Investigations into the mechanism of excitant amino acid cytotoxicity using a well-characterized glutamatergic system.
    Brain research, 1983, Mar-14, Volume: 263, Issue:1

    Topics: Animals; Aspartic Acid; Concanavalin A; Cysteine; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; Grasshoppers; Kainic Acid; Nerve Degeneration; Neuromuscular Junction; Neurotransmitter Agents; Oxadiazoles; Quisqualic Acid; Receptors, Cell Surface; Receptors, Glutamate; Synaptic Transmission

1983
Oral glutamate loading in disorders with spinocerebellar and extrapyramidal involvement: effect on plasma glutamate, aspartate and taurine.
    Journal of neural transmission. Supplementum, 1983, Volume: 19

    Topics: Aspartic Acid; Atrophy; Basal Ganglia Diseases; Cerebellar Diseases; Cerebellum; Friedreich Ataxia; Glutamate Dehydrogenase; Glutamates; Glutamic Acid; Humans; Nerve Degeneration; Olivary Nucleus; Parkinson Disease; Pons; Shy-Drager Syndrome; Sodium Glutamate; Spinal Cord Diseases; Taurine

1983
Sensitive and insensitive states of cultured glioma cells to glutamate damage.
    Brain research, 1984, Jun-15, Volume: 303, Issue:2

    Topics: 2-Aminoadipic Acid; Animals; Bucladesine; Cell Differentiation; Cell Line; Cells, Cultured; Flow Cytometry; Glioma; Glutamates; Glutamic Acid; Hydrocortisone; Nerve Degeneration; Rats

1984
Glutamate-mediated excitotoxic death of cultured striatal neurons is mediated by non-NMDA receptors.
    Experimental neurology, 1995, Volume: 136, Issue:2

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Basal Ganglia; Cell Death; Cells, Cultured; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Glutamic Acid; Kainic Acid; Nerve Degeneration; Pregnancy; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate

1995
Early-onset epilepsy and postnatal lethality associated with an editing-deficient GluR-B allele in mice.
    Science (New York, N.Y.), 1995, Dec-08, Volume: 270, Issue:5242

    Topics: Alleles; Animals; Base Sequence; Calcium; Epilepsy; Gene Targeting; Glutamic Acid; Heterozygote; Hippocampus; In Situ Hybridization; Male; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Nerve Degeneration; Neurons; Polymerase Chain Reaction; Purkinje Cells; Pyramidal Cells; Receptors, AMPA; RNA Editing; RNA Precursors

1995
Nicotine-induced protection of cultured cortical neurons against N-methyl-D-aspartate receptor-mediated glutamate cytotoxicity.
    Brain research, 1994, May-02, Volume: 644, Issue:2

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Glutamates; Glutamic Acid; Nerve Degeneration; Neurons; Nicotine; Parasympathetic Nervous System; Parasympathomimetics; Piperazines; Rats; Receptors, N-Methyl-D-Aspartate

1994
Propofol protects cultured rat hippocampal neurons against N-methyl-D-aspartate receptor-mediated glutamate toxicity.
    Journal of neurosurgical anesthesiology, 1994, Volume: 6, Issue:4

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Ischemia; Cells, Cultured; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Fetus; Glutamic Acid; Hippocampus; Kainic Acid; N-Methylaspartate; Nerve Degeneration; Neurons; Phosphopyruvate Hydratase; Propofol; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Time Factors

1994
Histamine-mediated neuronal death in a rat model of Wernicke's encephalopathy.
    Journal of neuroscience research, 1994, Aug-01, Volume: 38, Issue:5

    Topics: Animals; Cell Death; Disease Models, Animal; Gliosis; Glutamic Acid; Glutamine; Hippocampus; Histamine; Histamine Release; Male; Methylhistidines; Microdialysis; Necrosis; Nerve Degeneration; Neuroglia; Pyrithiamine; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Thalamus; Thiamine Deficiency; Wernicke Encephalopathy

1994
Nitric oxide does not mediate acute glutamate neurotoxicity, nor is it neuroprotective, in rat brain slices.
    Neuropharmacology, 1994, Volume: 33, Issue:11

    Topics: Amino Acid Oxidoreductases; Animals; Arginine; Cerebellum; Excitatory Amino Acids; Glutamic Acid; Hippocampus; In Vitro Techniques; N-Methylaspartate; Nerve Degeneration; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Rats; Rats, Wistar

1994
Interleukin-1 beta attenuates excitatory amino acid-induced neurodegeneration in vitro: involvement of nerve growth factor.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1995, Volume: 15, Issue:5 Pt 1

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Antibodies, Monoclonal; Cell Death; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Excitatory Amino Acids; Fetus; Glutamic Acid; Humans; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Kainic Acid; Kinetics; N-Methylaspartate; Nerve Degeneration; Nerve Growth Factors; Neurons; Neurotoxins; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Sialoglycoproteins

1995
Glutamate as a hippocampal neuron survival factor: an inherited defect in the trisomy 16 mouse.
    Proceedings of the National Academy of Sciences of the United States of America, 1995, Oct-10, Volume: 92, Issue:21

    Topics: Animals; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Fibroblast Growth Factor 2; Glutamic Acid; Hippocampus; Mice; Nerve Degeneration; Neurons; Receptors, AMPA; Receptors, Kainic Acid; Trisomy

1995
Antisense strategy unravels tau proteins as molecular risk factors for glutamate-induced neurodegeneration.
    Cellular and molecular neurobiology, 1994, Volume: 14, Issue:5

    Topics: Animals; Base Sequence; Cells, Cultured; Cerebellar Cortex; Cytoskeleton; Glutamic Acid; Molecular Sequence Data; Nerve Degeneration; Oligonucleotides, Antisense; Rats; Rats, Sprague-Dawley; Risk Factors; RNA Processing, Post-Transcriptional; RNA, Messenger; Single-Blind Method; tau Proteins

1994
Death of septal cholinergic neurons produced by chronic exposure to glutamate is prevented by the noncompetitive NMDA receptor/channel antagonist, MK-801: role of nerve growth factor and nitric oxide.
    Journal of neuroscience research, 1995, Apr-15, Volume: 40, Issue:6

    Topics: Animals; Cell Death; Cells, Cultured; Dizocilpine Maleate; Excitatory Amino Acids; Glutamic Acid; NADPH Dehydrogenase; Nerve Degeneration; Nerve Growth Factors; Neurons; Nitric Oxide; Parasympathetic Nervous System; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Septum Pellucidum

1995
Excess extracellular and low intracellular glutamate in poorly differentiating wobbler astrocytes and astrocyte recovery in glutamine-depleted culture medium.
    Journal of neurochemistry, 1995, Volume: 65, Issue:3

    Topics: Animals; Astrocytes; Cell Communication; Cell Differentiation; Cells, Cultured; Culture Media; Extracellular Space; Glutamic Acid; Glutamine; Mice; Mice, Inbred C57BL; Mice, Neurologic Mutants; Nerve Degeneration; Spinal Cord

1995
Evidence for a glutamatergic pathway from the guinea pig auditory cortex to the inferior colliculus.
    Journal of neurochemistry, 1995, Volume: 65, Issue:3

    Topics: Aspartic Acid; Auditory Cortex; Calcium; Carbon Radioisotopes; Electric Stimulation; Female; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Inferior Colliculi; Male; Nerve Degeneration; Nerve Fibers; Neural Pathways; Tritium

1995
Glutamate receptor-induced 45Ca2+ accumulation in cortical cell culture correlates with subsequent neuronal degeneration.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1993, Volume: 13, Issue:5

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Calcium Radioisotopes; Cells, Cultured; Cerebral Cortex; Glutamates; Glutamic Acid; Ibotenic Acid; N-Methylaspartate; Nerve Degeneration; Neurons; Quinoxalines; Receptors, Glutamate

1993
Accumulation of extracellular glutamate by inhibition of its uptake is not sufficient for inducing neuronal damage: an in vivo microdialysis study.
    Journal of neurochemistry, 1995, Volume: 64, Issue:5

    Topics: Animals; Cell Death; Choline; Choline O-Acetyltransferase; Corpus Striatum; Dicarboxylic Acids; Dizocilpine Maleate; Extracellular Space; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamic Acid; Kainic Acid; Male; Microdialysis; Nerve Degeneration; Neurons; Neurotransmitter Uptake Inhibitors; Pyrrolidines; Quinoxalines; Rats; Rats, Wistar

1995
Delayed excitotoxic neurodegeneration induced by excitatory amino acid agonists in isolated retina.
    Journal of neurochemistry, 1995, Volume: 65, Issue:1

    Topics: Animals; Cell Death; Chick Embryo; Excitatory Amino Acids; Glutamic Acid; In Vitro Techniques; L-Lactate Dehydrogenase; Nerve Degeneration; Neurotoxins; Retina

1995
Properties of neuroprotective cell-permeant Ca2+ chelators: effects on [Ca2+]i and glutamate neurotoxicity in vitro.
    Journal of neurophysiology, 1994, Volume: 72, Issue:4

    Topics: Animals; Calcium; Cell Survival; Cells, Cultured; Egtazic Acid; Fetus; Glutamic Acid; Mice; Nerve Degeneration; Neurons; Spinal Cord; Synaptic Transmission

1994
Modifications of glial metabolism of glutamate after serotonergic neuron degeneration in the hippocampus of the rat.
    Brain research. Molecular brain research, 1994, Volume: 26, Issue:1-2

    Topics: 5,7-Dihydroxytryptamine; Animals; Astrocytes; Cell Communication; Fenclonine; Gene Expression; Glial Fibrillary Acidic Protein; Glutamate Dehydrogenase; Glutamate-Ammonia Ligase; Glutamic Acid; Hippocampus; Hypertrophy; Male; Nerve Degeneration; Neuroglia; Neurons; Neurotoxins; Rats; Rats, Sprague-Dawley; Serotonin; Thymidine

1994
MPTP-induced degeneration: interference with glutamatergic toxicity.
    Journal of neural transmission. Supplementum, 1994, Volume: 43

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Chromatography, High Pressure Liquid; Dopamine; Glutamic Acid; Male; Mice; Mice, Inbred C57BL; Nerve Degeneration; Piperazines; Receptors, N-Methyl-D-Aspartate; Serotonin

1994
Neuroprotective effects of TGF-beta 1.
    Journal of neural transmission. Supplementum, 1994, Volume: 43

    Topics: Animals; Brain Ischemia; Cells, Cultured; Cerebral Cortex; Chick Embryo; Glutamic Acid; Hypoxia; Male; Mice; Mice, Inbred Strains; Nerve Degeneration; Neurons; Neuroprotective Agents; Rats; Rats, Inbred F344; Telencephalon; Transforming Growth Factor beta

1994
Neuroprotective properties of the novel antiepileptic lamotrigine in a gerbil model of global cerebral ischemia.
    Stroke, 1995, Volume: 26, Issue:3

    Topics: Animals; Anticonvulsants; Arterial Occlusive Diseases; Behavior, Animal; Brain Chemistry; Brain Ischemia; Carotid Artery Diseases; Cell Death; Cognition; Disease Models, Animal; Gerbillinae; Glutamic Acid; Hippocampus; Lamotrigine; Male; Memory; Nerve Degeneration; Neurons; Neuroprotective Agents; Pyramidal Cells; Reperfusion Injury; Triazines

1995
An aggregate brain cell culture model for studying neuronal degeneration and regeneration.
    Journal of neural transmission. Supplementum, 1994, Volume: 44

    Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Acetylcholinesterase; Animals; Biomarkers; Cell Aggregation; Choline O-Acetyltransferase; Dizocilpine Maleate; DNA; Fetus; Gestational Age; Glutamate-Ammonia Ligase; Glutamic Acid; L-Lactate Dehydrogenase; N-Methylaspartate; Nerve Degeneration; Nerve Regeneration; Neuroglia; Neurons; Rats; Reproducibility of Results; Telencephalon

1994
Effect of serum on intracellular calcium homeostasis and survival of primary cortical and hippocampal CA1 neurons following brief glutamate treatment.
    Metabolic brain disease, 1994, Volume: 9, Issue:4

    Topics: Animals; Blood; Blood Proteins; Calcium; Cell Death; Cell Survival; Cells, Cultured; Glutamic Acid; Hippocampus; Horses; L-Lactate Dehydrogenase; Nerve Degeneration; Neurons; Rats; Rats, Wistar

1994
Ultrastructural evidence that mercuric chloride lowers the threshold for glutamate neurotoxicity in an organotypic culture of rat cerebellum.
    Neuroscience letters, 1993, Aug-20, Volume: 158, Issue:2

    Topics: Animals; Animals, Newborn; Astrocytes; Cerebellar Diseases; Drug Synergism; Glutamates; Glutamic Acid; Mercuric Chloride; Nerve Degeneration; Neuroglia; Neurotransmitter Agents; Organ Culture Techniques; Rats; Rats, Wistar

1993
Protection by dihydroergocryptine of glutamate-induced neurotoxicity.
    Pharmacology & toxicology, 1993, Volume: 73, Issue:4

    Topics: Aging; Animals; Cell Survival; Cells, Cultured; Cerebellar Cortex; Dihydroergotoxine; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Fluoresceins; Glutamates; Glutamic Acid; Nerve Degeneration; Neurons; Peroxides; Propidium; Rats

1993
Comparison of double fluorescence staining and LDH-test for monitoring cell viability in vitro.
    Neuroreport, 1993, Nov-18, Volume: 5, Issue:2

    Topics: Animals; Biomarkers; Cell Survival; Cells, Cultured; Cerebral Cortex; Culture Media, Conditioned; Cytological Techniques; Fluoresceins; Fluorescent Dyes; Glutamates; Glutamic Acid; Hydrolysis; Kainic Acid; L-Lactate Dehydrogenase; Microscopy, Fluorescence; N-Methylaspartate; Nerve Degeneration; Nerve Tissue Proteins; Neuroglia; Neurons; Neurotoxins; Propidium; Quinolinic Acid; Rats; Rats, Wistar

1993
The effects of megadose methylprednisolone and U-78517F on toxicity mediated by glutamate receptors in the rat neostriatum.
    Neurosurgery, 1994, Volume: 34, Issue:1

    Topics: Animals; Cell Survival; Chromans; Corpus Striatum; Dose-Response Relationship, Drug; Energy Metabolism; Free Radical Scavengers; Glutamates; Glutamic Acid; Lipid Peroxidation; Male; Methylprednisolone Hemisuccinate; Nerve Degeneration; Piperazines; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate

1994
Chronic inhibition of superoxide dismutase produces apoptotic death of spinal neurons.
    Proceedings of the National Academy of Sciences of the United States of America, 1994, May-10, Volume: 91, Issue:10

    Topics: Acetylcysteine; Amyotrophic Lateral Sclerosis; Animals; Animals, Newborn; Anti-Anxiety Agents; Antioxidants; Apoptosis; Base Sequence; Benzodiazepines; Biological Transport; Choline O-Acetyltransferase; Chromans; Ditiocarb; Glutamates; Glutamic Acid; Humans; Molecular Sequence Data; Motor Neurons; Nerve Degeneration; Neurotoxins; Oligonucleotides, Antisense; Organ Culture Techniques; Piperazines; Rats; Spinal Cord; Superoxide Dismutase

1994
Basic fibroblast growth factor modulates sensitivity of cultured hippocampal pyramidal neurons to glutamate cytotoxicity: interaction with ganglioside GM1.
    Brain research. Developmental brain research, 1993, Jan-15, Volume: 71, Issue:1

    Topics: Animals; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Drug Synergism; Fibroblast Growth Factor 2; G(M1) Ganglioside; Glutamates; Glutamic Acid; Hippocampus; Kinetics; Nerve Degeneration; Neurons; Neurotoxins; Pyramidal Tracts; Rats; Rats, Sprague-Dawley; Time Factors

1993
Glutamate neurotoxicity: a role for non-N-methyl-D-aspartate receptors?
    Biochemical Society transactions, 1993, Volume: 21, Issue:1

    Topics: Animals; Brain; Cells, Cultured; Choline O-Acetyltransferase; Glutamates; Glutamic Acid; Kainic Acid; N-Methylaspartate; Nerve Degeneration; Quisqualic Acid; Rats; Receptors, N-Methyl-D-Aspartate; Somatostatin

1993
An evaluation of the role of extracellular amino acids in the delayed neurodegeneration induced by quinolinic acid in the rat striatum.
    Neuroscience, 1993, Volume: 52, Issue:4

    Topics: Amino Acids; Animals; Asparagine; Aspartic Acid; Corpus Striatum; Dialysis; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; Male; Microinjections; Nerve Degeneration; Niacin; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Serine; Threonine

1993
Isoform-specific effects of transforming growth factors-beta on degeneration of primary neuronal cultures induced by cytotoxic hypoxia or glutamate.
    Journal of neurochemistry, 1993, Volume: 60, Issue:5

    Topics: Animals; Cell Hypoxia; Cells, Cultured; Cerebral Cortex; Chick Embryo; Glutamates; Glutamic Acid; Isomerism; Nerve Degeneration; Neurons; Telencephalon; Transforming Growth Factor beta

1993
Glutamate-induced neuronal death is not a programmed cell death in cerebellar culture.
    Journal of neurochemistry, 1993, Volume: 60, Issue:5

    Topics: Animals; Apoptosis; Aurintricarboxylic Acid; Cell Survival; Cells, Cultured; Cerebellum; DNA; Electrophoresis, Agar Gel; Glutamates; Glutamic Acid; Nerve Degeneration; Neurons

1993
Combined oxygen and glucose deprivation in cortical cell culture: calcium-dependent and calcium-independent mechanisms of neuronal injury.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1993, Volume: 13, Issue:8

    Topics: Animals; Calcium; Calcium Radioisotopes; Cell Death; Cells, Cultured; Cerebral Cortex; Chlorides; Extracellular Space; Glucose; Glutamates; Glutamic Acid; Hydrogen-Ion Concentration; Immunohistochemistry; Kinetics; L-Lactate Dehydrogenase; Mice; Nerve Degeneration; Neuroglia; Neurons; Oxygen; Receptors, N-Methyl-D-Aspartate; Sodium

1993
Neurodegeneration mediated by glutamate and beta-amyloid peptide: a comparison and possible interaction.
    Brain research, 1995, Sep-11, Volume: 691, Issue:1-2

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Astrocytes; Cell Death; Cells, Cultured; Cerebral Cortex; Culture Media; Glutamic Acid; Hippocampus; L-Lactate Dehydrogenase; Nerve Degeneration; Neuropeptides; Peptide Fragments; Rats; Rats, Wistar

1995
A neuronal cell protecting substance, 4-demethoxymichigazone, produced by Streptomyces halstedii.
    The Journal of antibiotics, 1996, Volume: 49, Issue:3

    Topics: Animals; Cell Line; Central Nervous System Agents; Glutamic Acid; Hybridomas; Magnetic Resonance Spectroscopy; Molecular Structure; Nerve Degeneration; Oxazines; Spectrometry, Mass, Fast Atom Bombardment; Streptomyces

1996
Quantitative changes of amino acid distributions in the rat vestibular nuclear complex after unilateral vestibular ganglionectomy.
    Journal of neurochemistry, 1996, Volume: 66, Issue:4

    Topics: Amino Acids; Animals; Aspartic Acid; Behavior, Animal; gamma-Aminobutyric Acid; Ganglionectomy; Glutamic Acid; Glutamine; Glycine; Male; Nerve Degeneration; Neurotransmitter Agents; Rats; Rats, Sprague-Dawley; Taurine; Vestibular Nuclei

1996
Disturbances in the distribution of neurotransmitters in the rat retina after ischemia.
    Current eye research, 1996, Volume: 15, Issue:6

    Topics: Animals; gamma-Aminobutyric Acid; Glutamic Acid; Immunohistochemistry; Intraocular Pressure; Ischemia; Nerve Degeneration; Neuroglia; Neurotransmitter Agents; Rats; Rats, Inbred Lew; Reperfusion Injury; Retina; Retinal Vessels; Tissue Distribution

1996
Proton magnetic resonance spectroscopy in Huntington's disease: evidence in favour of the glutamate excitotoxic theory.
    Movement disorders : official journal of the Movement Disorder Society, 1996, Volume: 11, Issue:2

    Topics: Aspartic Acid; Cerebral Cortex; Corpus Striatum; Genetic Carrier Screening; Glutamic Acid; Glutamine; Humans; Huntington Disease; Magnetic Resonance Imaging; Nerve Degeneration; Reference Values; Synaptic Transmission

1996
Vicious cycle involving Na+ channels, glutamate release, and NMDA receptors mediates delayed neurodegeneration through nitric oxide formation.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1996, Aug-15, Volume: 16, Issue:16

    Topics: Amino Acids; Animals; Glutamic Acid; Immunohistochemistry; Kinetics; Nerve Degeneration; Nitric Oxide; Nitric Oxide Synthase; Rats; Receptors, N-Methyl-D-Aspartate; Sodium Channels; Tetrodotoxin; Time Factors

1996
The effects of ketamine-isomers on neuronal injury and regeneration in rat hippocampal neurons.
    Anesthesia and analgesia, 1996, Volume: 83, Issue:3

    Topics: Anesthetics, Dissociative; Animals; Axons; Cell Survival; Cells, Cultured; Dendrites; Glutamic Acid; Hippocampus; Isomerism; Ketamine; Nerve Degeneration; Nerve Regeneration; Rats; Rats, Sprague-Dawley

1996
Inhibition of glutamate uptake induces progressive accumulation of extracellular glutamate and neuronal damage in rat cortical cultures.
    Journal of neuroscience research, 1996, Jun-15, Volume: 44, Issue:6

    Topics: Animals; Anti-Bacterial Agents; Aspartic Acid; Cells, Cultured; Cerebral Cortex; Dicarboxylic Acids; Excitatory Amino Acid Antagonists; Extracellular Space; Glutamic Acid; Kainic Acid; L-Lactate Dehydrogenase; Nerve Degeneration; Neurons; Neurotransmitter Uptake Inhibitors; Pyrrolidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate

1996
Beta-amyloid precursor protein (APP) and APP-RNA are rapidly affected by glutamate in cultured neurons: selective increase of mRNAs encoding a Kunitz protease inhibitor domain.
    Journal of molecular neuroscience : MN, 1995, Volume: 6, Issue:4

    Topics: Amyloid beta-Protein Precursor; Animals; Blotting, Western; Cell Death; Cells, Cultured; Cerebral Cortex; Dogs; Dose-Response Relationship, Drug; Gene Expression Regulation; Glutamic Acid; Iodine Radioisotopes; Isomerism; Kidney Tubules, Distal; Nerve Degeneration; Neurons; Rats; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Transfection; Trypsin

1995
Absence of excitotoxic neuropathology in microencephalic rats after systemic kainic acid administration.
    Neuroscience letters, 1996, Oct-25, Volume: 218, Issue:1

    Topics: Animals; Cell Death; Female; Glutamic Acid; Hippocampus; Kainic Acid; Male; Nerve Degeneration; Olfactory Pathways; Pregnancy; Rats; Rats, Wistar

1996
Neurochemical architecture of the normal and degenerating rat retina.
    The Journal of comparative neurology, 1996, Dec-16, Volume: 376, Issue:3

    Topics: Amino Acids; Animals; Antibody Specificity; Arginine; Aspartic Acid; Autoradiography; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Immunohistochemistry; Nerve Degeneration; Neurotransmitter Agents; Photoreceptor Cells; Pigment Epithelium of Eye; Rats; Rats, Inbred Strains; Taurine; Tritium

1996
An improved model for examining delayed excitotoxic neurodegeneration in isolated chick retina.
    Neuroscience letters, 1996, Nov-15, Volume: 219, Issue:1

    Topics: Animals; Chick Embryo; Dose-Response Relationship, Drug; Glucose; Glutamic Acid; L-Lactate Dehydrogenase; Models, Neurological; Nerve Degeneration; Retina

1996
Acetyl-L-carnitine arginine amide prevents beta 25-35-induced neurotoxicity in cerebellar granule cells.
    Neurochemical research, 1997, Volume: 22, Issue:3

    Topics: Acetylcarnitine; Amyloid beta-Peptides; Animals; Arginine; Basal Metabolism; Cells, Cultured; Cerebellum; Drug Evaluation, Preclinical; Glutamic Acid; Homeostasis; Nerve Degeneration; Nerve Growth Factors; Neurons; Neurotoxins; Peptide Fragments; Rats; Rats, Wistar; Video Recording

1997
Inhibition of the electrogenic Na pump underlies delayed depolarization of cortical neurons after mechanical injury or glutamate.
    Journal of neurophysiology, 1997, Volume: 77, Issue:2

    Topics: Action Potentials; Animals; Cells, Cultured; Cerebral Cortex; Glutamic Acid; Nerve Degeneration; Rats; Sodium-Potassium-Exchanging ATPase

1997
Frontotemporal dementia and early Alzheimer disease: differentiation with frontal lobe H-1 MR spectroscopy.
    Radiology, 1997, Volume: 203, Issue:3

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Dementia; Discriminant Analysis; Female; Frontal Lobe; Glutamic Acid; Glutamine; Humans; Hydrogen; Inositol; Lactates; Linear Models; Magnetic Resonance Spectroscopy; Male; Middle Aged; Nerve Degeneration; Neuroglia; Neurons; Parietal Lobe; Protons; Sensitivity and Specificity; Temporal Lobe

1997
Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1.
    Science (New York, N.Y.), 1997, Jun-13, Volume: 276, Issue:5319

    Topics: Amino Acid Transport System X-AG; Animals; ATP-Binding Cassette Transporters; Biological Transport; Brain; Brain Injuries; Electroencephalography; Epilepsy; Gene Targeting; Glutamic Acid; Hippocampus; Mice; Mice, Inbred C57BL; Nerve Degeneration; Pyramidal Cells; Synapses; Synaptic Transmission

1997
Etiology of (CAG)n triplet repeat neurodegenerative diseases such as Huntington's disease is connected to stimulation of glutamate receptors.
    Medical hypotheses, 1997, Volume: 48, Issue:5

    Topics: Autoimmunity; Cerebrovascular Disorders; Epilepsy; Glutamic Acid; Humans; Huntington Disease; Minisatellite Repeats; Models, Biological; Nerve Degeneration; Receptors, Glutamate; Trinucleotide Repeats

1997
Iodoacetate produces striatal excitotoxic lesions.
    Journal of neurochemistry, 1997, Volume: 69, Issue:1

    Topics: Animals; Corpus Striatum; Glutamic Acid; Glyceraldehyde-3-Phosphate Dehydrogenases; Iodoacetates; Iodoacetic Acid; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; NADPH Dehydrogenase; Nerve Degeneration; Neurotoxins; Oxidative Stress; Rats; Rats, Sprague-Dawley

1997
Differential glutamate immunoreactivity in glial cells of the retino-recipient layer of the viper optic tectum following retinal ablation. A quantitative EM immunogold study.
    Brain research, 1997, Jul-04, Volume: 761, Issue:2

    Topics: Animals; Axons; Denervation; Female; Glutamic Acid; Immunohistochemistry; Male; Microscopy, Immunoelectron; Nerve Degeneration; Neuroglia; Presynaptic Terminals; Retina; Superior Colliculi; Viperidae

1997
Glutamate uptake impairment and neuronal damage in young and aged rats in vivo.
    Journal of neurochemistry, 1997, Volume: 69, Issue:3

    Topics: Aging; Amino Acids; Animals; Aspartic Acid; Corpus Striatum; Dicarboxylic Acids; Glutamic Acid; Hippocampus; Kainic Acid; Kinetics; Male; Microdialysis; Nerve Degeneration; Neurons; Neurotransmitter Uptake Inhibitors; Pyrrolidines; Rats; Rats, Wistar

1997
Status epilepticus-induced alterations in metabotropic glutamate receptor expression in young and adult rats.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997, Nov-01, Volume: 17, Issue:21

    Topics: Aging; Animals; Animals, Suckling; Cell Death; Dentate Gyrus; Excitatory Amino Acid Agonists; Gene Expression Regulation, Developmental; Glutamic Acid; In Situ Hybridization, Fluorescence; Kainic Acid; Male; Mossy Fibers, Hippocampal; Nerve Degeneration; Nerve Tissue Proteins; Pyramidal Cells; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; RNA, Messenger; Status Epilepticus

1997
Continuous administration of the glutamate uptake inhibitor L-trans-pyrrolidine-2,4-dicarboxylate produces striatal lesion.
    Brain research. Molecular brain research, 1997, Oct-15, Volume: 50, Issue:1-2

    Topics: Animals; Biological Transport; Corpus Striatum; Dicarboxylic Acids; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; In Situ Hybridization; Infusion Pumps, Implantable; Molecular Weight; Nerve Degeneration; Neurotransmitter Uptake Inhibitors; Osmotic Pressure; Pyrrolidines; Rats; Rats, Wistar

1997
Neurotoxic responses by microglia elicited by excitotoxic injury in the mouse hippocampus.
    Current biology : CB, 1998, Jan-01, Volume: 8, Issue:1

    Topics: Animals; Cell Death; Cells, Cultured; Excitatory Amino Acid Agonists; Female; Glutamic Acid; Hippocampus; Kainic Acid; Macrophage Migration-Inhibitory Factors; Male; Mice; Mice, Inbred C57BL; Microglia; Nerve Degeneration; Neurons; Pregnancy; Tissue Plasminogen Activator

1998
Trimethyltin (TMT) neurotoxicity in organotypic rat hippocampal slice cultures.
    Brain research, 1998, Feb-09, Volume: 783, Issue:2

    Topics: Animals; Cobalt; Coloring Agents; Glutamic Acid; Hippocampus; Immunohistochemistry; L-Lactate Dehydrogenase; Microtubule-Associated Proteins; Nerve Degeneration; Neurons, Afferent; Neurotoxins; Nissl Bodies; Organ Culture Techniques; Propidium; Rats; Rats, Wistar; Trimethyltin Compounds

1998
Calbindin-D28k buffers intracellular calcium and promotes resistance to degeneration in PC12 cells.
    Brain research. Molecular brain research, 1998, Volume: 54, Issue:1

    Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Calbindin 1; Calbindins; Calcimycin; Calcium; Culture Media, Serum-Free; Drug Resistance, Neoplasm; Glutamic Acid; Intracellular Fluid; Nerve Degeneration; Nerve Tissue Proteins; PC12 Cells; Rats; S100 Calcium Binding Protein G; Time Factors

1998
4-hydroxynonenal, a lipid peroxidation product, impairs glutamate transport in cortical astrocytes.
    Glia, 1998, Volume: 22, Issue:2

    Topics: Aldehydes; Animals; Antioxidants; Astrocytes; Blotting, Western; Cells, Cultured; Cerebral Cortex; Cysteine Proteinase Inhibitors; Glutamic Acid; Immunohistochemistry; L-Lactate Dehydrogenase; Lipid Peroxidation; Mitochondria; Nerve Degeneration; Oxidative Stress; Precipitin Tests; Rats; Rats, Sprague-Dawley

1998
Interleukin-1 beta and interleukin-1 receptor antagonist do not affect glutamate release or calcium entry in rat striatal synaptosomes.
    Molecular psychiatry, 1998, Volume: 3, Issue:2

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cerebral Cortex; Chelating Agents; Corpus Striatum; Egtazic Acid; Glutamates; Glutamic Acid; Humans; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Ion Transport; Male; Membrane Potentials; Nerve Degeneration; Neurotoxins; Potassium Chloride; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Sialoglycoproteins; Synaptosomes

1998
The diazoxide derivative IDRA 21 enhances ischemic hippocampal neuron injury.
    Annals of neurology, 1998, Volume: 43, Issue:5

    Topics: Animals; Benzothiadiazines; Brain Ischemia; Cells, Cultured; Diazoxide; Diuretics; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Nerve Degeneration; Neurons; Neurotoxins; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, AMPA; Sodium Chloride Symporter Inhibitors

1998
Glutamate neurotoxicity is associated with nitric oxide-mediated mitochondrial dysfunction and glutathione depletion.
    Brain research, 1998, Apr-20, Volume: 790, Issue:1-2

    Topics: 2-Amino-5-phosphonovalerate; Animals; Antimycin A; Cell Respiration; Cells, Cultured; Cerebral Cortex; Cyclic GMP; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glucose; Glutamic Acid; Glutathione; Mitochondria; Nerve Degeneration; Nerve Tissue Proteins; Neurons; Neurotoxins; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Radiation-Protective Agents; Rats; Rats, Wistar; Rotenone; Succinic Acid; Uncoupling Agents

1998
Spinal cord GLT-1 glutamate transporter and blood glutamic acid alterations in motor neuron degeneration (Mnd) mice.
    Journal of the neurological sciences, 1998, Apr-15, Volume: 157, Issue:1

    Topics: Amino Acid Transport System X-AG; Animals; ATP-Binding Cassette Transporters; Corpus Striatum; Dopamine; Glutamic Acid; Hippocampus; Immunoblotting; Male; Mice; Motor Neurons; Nerve Degeneration; Serotonin; Spinal Cord

1998
Elevation of intraocular glutamate levels in rats with partial lesion of the optic nerve.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1998, Volume: 116, Issue:7

    Topics: Animals; Aqueous Humor; Aspartic Acid; Cell Death; Chromatography, High Pressure Liquid; Glutamic Acid; Male; Nerve Crush; Nerve Degeneration; Nerve Fibers; Optic Nerve Diseases; Optic Nerve Injuries; Rats; Rats, Sprague-Dawley; Retinal Ganglion Cells

1998
Further evidence that Cerebrolysin protects cortical neurons from neurodegeneration in vitro.
    Journal of neural transmission. Supplementum, 1998, Volume: 53

    Topics: Amino Acids; Animals; Cells, Cultured; Cerebral Cortex; Chick Embryo; Excitatory Amino Acids; Glutamic Acid; Iron; Microtubule-Associated Proteins; Nerve Degeneration; Neurons; Nootropic Agents

1998
Exogenous glutamate enhances glutamate receptor subunit expression during selective neuronal injury in the ventral arcuate nucleus of postnatal mice.
    Neuroendocrinology, 1998, Volume: 68, Issue:2

    Topics: Animals; Animals, Suckling; Apoptosis; Arcuate Nucleus of Hypothalamus; Brain Chemistry; Cerebral Ventricles; Dose-Response Relationship, Drug; Female; Food Additives; Glutamic Acid; Immunohistochemistry; Median Eminence; Mice; Mice, Inbred Strains; Microscopy, Electron; Necrosis; Nerve Degeneration; Neurons; Receptors, Glutamate; Sodium Glutamate; Tyrosine 3-Monooxygenase

1998
Ginsenosides Rb1 and Rg3 protect cultured rat cortical cells from glutamate-induced neurodegeneration.
    Journal of neuroscience research, 1998, Aug-15, Volume: 53, Issue:4

    Topics: Animals; Calcium; Cell Survival; Cells, Cultured; Cerebral Cortex; Fetus; Ginsenosides; Glutamic Acid; Lipid Peroxidation; Malondialdehyde; Nerve Degeneration; Neurons; Neurotoxins; Panax; Plants, Medicinal; Rats; Rats, Sprague-Dawley; Saponins; Superoxide Dismutase

1998
Effect of glucose deprivation and acute glutamate exposure in cultured retinal cells.
    Experimental neurology, 1998, Volume: 153, Issue:1

    Topics: Adenine Nucleotides; Animals; Calcium; Cell Membrane; Cell Survival; Cells, Cultured; Energy Metabolism; Excitatory Amino Acids; Glucose; Glutamic Acid; Nerve Degeneration; Rats; Retina

1998
Tirilazad widens the therapeutic window for riluzole-induced attenuation of progressive cortical degeneration in an infant rat model of the shaken baby syndrome.
    Journal of neurotrauma, 1998, Volume: 15, Issue:9

    Topics: Age Factors; Animals; Battered Child Syndrome; Body Temperature; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Free Radical Scavengers; Glutamic Acid; Head Injuries, Closed; Humans; Hypoxia; Infant; Lipid Peroxidation; Male; Nerve Degeneration; Neuroprotective Agents; Pregnatrienes; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Riluzole; Time Factors

1998
Neuronal degeneration in rat forebrain resulting from D-amphetamine-induced convulsions is dependent on seizure severity and age.
    Brain research, 1998, Oct-26, Volume: 809, Issue:1

    Topics: Age Factors; Animals; Basal Ganglia; Behavior, Animal; Body Temperature; Catecholamines; Dextroamphetamine; Epilepsy; Glutamic Acid; Limbic System; Male; Nerve Degeneration; Prosencephalon; Rats; Rats, Sprague-Dawley; Sympathomimetics

1998
Traumatic brain injury alters synaptic homeostasis: implications for impaired mitochondrial and transport function.
    Journal of neurotrauma, 1998, Volume: 15, Issue:10

    Topics: Adenosine Triphosphate; Analysis of Variance; Animals; Biological Transport, Active; Brain; Brain Injuries; Cerebral Cortex; Disease Models, Animal; Glucose; Glutamic Acid; Hippocampus; Homeostasis; Lipid Peroxidation; Male; Mitochondria; Nerve Degeneration; Oxidative Stress; Rats; Rats, Sprague-Dawley; Synapses; Synaptosomes; Time Factors

1998
Estradiol protects mesencephalic dopaminergic neurons from oxidative stress-induced neuronal death.
    Journal of neuroscience research, 1998, Dec-01, Volume: 54, Issue:5

    Topics: Animals; Cells, Cultured; Corticosterone; Dopamine; Estradiol; Estrogen Antagonists; Glutamic Acid; Hydrogen Peroxide; Mesencephalon; Nerve Degeneration; Neurons; Neuroprotective Agents; Oxidative Stress; Parkinson Disease; Rats; Reactive Oxygen Species; Stereoisomerism; Superoxides; Tamoxifen; Testosterone

1998
Transient inhibition of glutamate uptake in vivo induces neurodegeneration when energy metabolism is impaired.
    Journal of neurochemistry, 1999, Volume: 72, Issue:1

    Topics: Animals; Antihypertensive Agents; Aspartic Acid; Biological Transport; Brain Chemistry; Corpus Striatum; Dicarboxylic Acids; Energy Metabolism; Glutamic Acid; Hippocampus; Male; Microdialysis; Nerve Degeneration; Neurotoxins; Neurotransmitter Uptake Inhibitors; Nitro Compounds; Propionates; Pyrrolidines; Rats; Rats, Wistar

1999
The involvement of nitric oxide in synergistic neuronal damage induced by beta-amyloid peptide and glutamate in primary rat cortical neurons.
    The Chinese journal of physiology, 1998, Sep-30, Volume: 41, Issue:3

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cells, Cultured; Cerebral Cortex; Drug Synergism; Enzyme Inhibitors; Glutamic Acid; L-Lactate Dehydrogenase; Nerve Degeneration; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Peptide Fragments; Rats

1998
Hypothermia prevents biphasic glutamate release and corresponding neuronal degeneration after transient spinal cord ischemia in the rat.
    Cellular and molecular neurobiology, 1999, Volume: 19, Issue:2

    Topics: Animals; Combined Modality Therapy; Denervation; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Hypothermia, Induced; Injections, Spinal; Male; Microdialysis; Nerve Degeneration; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reperfusion Injury; Spinal Cord

1999
Brain neurotransmitter deficits in mice transgenic for the Huntington's disease mutation.
    Journal of neurochemistry, 1999, Volume: 72, Issue:4

    Topics: Animals; Brain Chemistry; Disease Models, Animal; Dopamine; gamma-Aminobutyric Acid; Glutamic Acid; Huntingtin Protein; Huntington Disease; Hydroxyindoleacetic Acid; Mice; Mice, Transgenic; Mutation; Nerve Degeneration; Nerve Tissue Proteins; Norepinephrine; Nuclear Proteins; Serotonin; Trinucleotide Repeats

1999
Brain temperature modifies glutamate neurotoxicity in vivo.
    Journal of neurotrauma, 1999, Volume: 16, Issue:4

    Topics: Analysis of Variance; Animals; Body Temperature; Brain; Brain Injuries; Carbon Radioisotopes; Disease Models, Animal; Disease Progression; Glutamic Acid; Hyperthermia, Induced; Hypothermia, Induced; Male; Microdialysis; Nerve Degeneration; Neurons; Rats; Rats, Wistar; Sucrose; Time Factors

1999
Distinguishing excitotoxic from apoptotic neurodegeneration in the developing rat brain.
    The Journal of comparative neurology, 1999, Jun-14, Volume: 408, Issue:4

    Topics: Animals; Apoptosis; Brain; Brain Injuries; Electrophoresis, Agar Gel; Glial Fibrillary Acidic Protein; Glutamic Acid; In Situ Nick-End Labeling; Microglia; Microscopy, Electron; Nerve Degeneration; Rats; Rats, Sprague-Dawley; Silver Staining

1999
Prostate apoptosis response-4 production in synaptic compartments following apoptotic and excitotoxic insults: evidence for a pivotal role in mitochondrial dysfunction and neuronal degeneration.
    Journal of neurochemistry, 1999, Volume: 72, Issue:6

    Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Brain; Carrier Proteins; Caspases; Cell Survival; Cells, Cultured; Dendrites; Female; Gene Expression Regulation; Glutamic Acid; Hippocampus; Intracellular Signaling Peptides and Proteins; Kainic Acid; Male; Mitochondria; Nerve Degeneration; Neurites; Neurons; Oligodeoxyribonucleotides, Antisense; Rats; Rats, Sprague-Dawley; Signal Transduction; Staurosporine; Synapses; Synaptosomes

1999
Neuroprotective utility and neurotrophic action of neurturin in postnatal motor neurons: comparison with GDNF and persephin.
    Molecular and cellular neurosciences, 1999, Volume: 13, Issue:5

    Topics: Animals; Cell Survival; Cells, Cultured; Choline O-Acetyltransferase; Enzyme Activation; Glial Cell Line-Derived Neurotrophic Factor; Glutamic Acid; Motor Neurons; Nerve Degeneration; Nerve Growth Factors; Nerve Tissue Proteins; Neurites; Neuroprotective Agents; Neurturin; Rats; Spinal Cord

1999
Interleukin-1beta immunoreactivity and microglia are enhanced in the rat hippocampus by focal kainate application: functional evidence for enhancement of electrographic seizures.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999, Jun-15, Volume: 19, Issue:12

    Topics: Animals; Antibodies; Anticonvulsants; Antirheumatic Agents; Bicuculline; Cell Count; Electroencephalography; Enzyme-Linked Immunosorbent Assay; Epilepsy; Excitatory Amino Acid Agonists; GABA Antagonists; Glutamic Acid; Hippocampus; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Kainic Acid; Male; Microglia; Nerve Degeneration; Neurons; Piperazines; Rats; Rats, Sprague-Dawley; Sialoglycoproteins

1999
1H-MRS evidence of neurodegeneration and excess glutamate + glutamine in ALS medulla.
    Neurology, 1999, Jul-13, Volume: 53, Issue:1

    Topics: Adult; Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Brain; Female; Glutamic Acid; Glutamine; Humans; Hydrogen; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Medulla Oblongata; Middle Aged; Nerve Degeneration; Reference Values

1999
Pigment epithelium-derived factor (PEDF) protects motor neurons from chronic glutamate-mediated neurodegeneration.
    Journal of neuropathology and experimental neurology, 1999, Volume: 58, Issue:7

    Topics: Animals; Cattle; Cell Survival; Cerebrospinal Fluid; Choline O-Acetyltransferase; Chronic Disease; Ependyma; Eye Proteins; Female; Glutamic Acid; Haplorhini; Humans; Motor Neurons; Muscle, Skeletal; Nerve Degeneration; Nerve Growth Factors; Neuroprotective Agents; Organ Culture Techniques; Proteins; Rats; RNA, Messenger; Serpins; Spinal Cord

1999
Increased volume and glial density in primate prefrontal cortex associated with chronic antipsychotic drug exposure.
    Biological psychiatry, 1999, Jul-15, Volume: 46, Issue:2

    Topics: Analysis of Variance; Animals; Antipsychotic Agents; Cell Count; Cell Movement; Culture Techniques; Dose-Response Relationship, Drug; Glutamic Acid; Macaca mulatta; Male; Nerve Degeneration; Neuroglia; Neurons; Prefrontal Cortex; Receptors, Dopamine D2

1999
Apoptotic pathways mobilized in microglia and neurones as a consequence of chromogranin A-induced microglial activation.
    Journal of neurochemistry, 1999, Volume: 73, Issue:2

    Topics: Alzheimer Disease; Animals; Apoptosis; Biomarkers; Caspase 1; Caspase 3; Caspase Inhibitors; Caspases; Cell Size; Cells, Cultured; Cerebellum; Chromogranin A; Chromogranins; Enzyme Inhibitors; Glial Fibrillary Acidic Protein; Glutamic Acid; Macrophages; Microglia; Nerve Degeneration; Neurons; Neurotoxins; Nitric Oxide; Nitroarginine; Oligopeptides; Rats

1999
Glutamate toxicity induced degeneration of outer hair cells with a temporal increase of nitric oxide production in the guinea pig cochlea.
    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 1999, Volume: 256, Issue:7

    Topics: Animals; Female; Glutamic Acid; Guinea Pigs; Hair Cells, Auditory, Outer; Male; Microscopy, Electron; NADPH Dehydrogenase; Nerve Degeneration; Nitric Oxide; Nitric Oxide Synthase; Organ of Corti; Vestibulocochlear Nerve Diseases

1999
Neurotoxicity of glutamate at the concentration released upon spinal cord injury.
    Neuroscience, 1999, Volume: 93, Issue:4

    Topics: Animals; Aspartic Acid; Contusions; Glutamic Acid; Male; Microdialysis; Nerve Degeneration; Neurotoxins; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Cord Injuries

1999
Loss of cyclin D1 in necrotic and apoptotic models of cortical neuronal degeneration.
    Brain research, 1999, Sep-25, Volume: 842, Issue:2

    Topics: Animals; Apoptosis; Cell Cycle; Cells, Cultured; Cerebral Cortex; Cyclin D1; Fetus; G1 Phase; Glutamic Acid; Kinetics; Models, Neurological; Necrosis; Nerve Degeneration; Neurons; Rats; Resting Phase, Cell Cycle; S Phase; Staurosporine

1999
Ischaemic pre-conditioning in organotypic hippocampal slice cultures is inversely correlated to the induction of the 72 kDa heat shock protein (HSP72).
    Brain research, 1999, Oct-23, Volume: 845, Issue:2

    Topics: Animals; Brain Ischemia; Excitatory Amino Acid Agonists; Glutamic Acid; Heat-Shock Proteins; Hippocampus; HSP72 Heat-Shock Proteins; Ischemic Preconditioning; Kainic Acid; N-Methylaspartate; Nerve Degeneration; Neurotoxins; Organ Culture Techniques; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate

1999
Dual responses of CNS mitochondria to elevated calcium.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000, Jan-01, Volume: 20, Issue:1

    Topics: Adenosine Diphosphate; Animals; Antineoplastic Agents; Atractyloside; Brain; Calcium; Electric Conductivity; Fluorescent Dyes; Fura-2; Glutamic Acid; Membrane Potentials; Mitochondria; Mitochondrial Swelling; Nerve Degeneration; Oligomycins; Onium Compounds; Organophosphorus Compounds; Oxidation-Reduction; Oxygen Consumption; Rats; Strontium; Succinic Acid; Uncoupling Agents

2000
Characterization of striatal lesions produced by glutamate uptake alteration: cell death, reactive gliosis, and changes in GLT1 and GADD45 mRNA expression.
    Glia, 2000, Feb-01, Volume: 29, Issue:3

    Topics: Animals; Calcium; Cell Death; Corpus Striatum; Female; GADD45 Proteins; Glial Fibrillary Acidic Protein; Gliosis; Glucose Transporter Type 1; Glutamic Acid; Intracellular Signaling Peptides and Proteins; Monoamine Oxidase; Monosaccharide Transport Proteins; Nerve Degeneration; Proteins; Rats; Rats, Wistar; Receptors, GABA-A; RNA, Messenger

2000
Cynandione A from Cynanchum wilfordii protects cultured cortical neurons from toxicity induced by H2O2, L-glutamate, and kainate.
    Journal of neuroscience research, 2000, Jan-15, Volume: 59, Issue:2

    Topics: Animals; Antioxidants; Biphenyl Compounds; Cells, Cultured; Cerebral Cortex; Excitatory Amino Acid Agonists; Fetus; Glutamic Acid; Hydrogen Peroxide; Kainic Acid; Nerve Degeneration; Neuroglia; Neurons; Neuroprotective Agents; Oxidants; Oxidative Stress; Plant Roots; Plants, Medicinal; Rats; Rats, Sprague-Dawley

2000
Distribution of glutamate and preproenkephalin messenger RNAs following transient focal cerebral ischemia.
    Neuroscience, 2000, Volume: 95, Issue:3

    Topics: Animals; Brain; Cerebral Infarction; Corpus Striatum; Down-Regulation; Enkephalins; Glutamic Acid; Ischemic Attack, Transient; Male; Neocortex; Nerve Degeneration; Neurons; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tissue Distribution

2000
Despite the internucleosomal cleavage of DNA, reactive oxygen species do not produce other markers of apoptosis in cultured neurons.
    Experimental neurology, 2000, Volume: 162, Issue:1

    Topics: Animals; Antioxidants; Apoptosis; Biomarkers; Caspases; Cell Nucleus; Cholinesterase Inhibitors; Comet Assay; Cycloheximide; DNA Fragmentation; Enzyme Inhibitors; Female; Free Radical Scavengers; Glutamic Acid; Metalloporphyrins; Molsidomine; Nerve Degeneration; Nerve Tissue Proteins; Neurons; Nucleosomes; Oxidation-Reduction; Phenanthrolines; Pregnancy; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Staurosporine; Uric Acid

2000
Bilateral blockade of NMDA receptors in anterior thalamus by dizocilpine (MK-801) injures pyramidal neurons in rat retrosplenial cortex.
    The European journal of neuroscience, 2000, Volume: 12, Issue:4

    Topics: Animals; Anterior Thalamic Nuclei; Baclofen; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Female; GABA Agonists; gamma-Aminobutyric Acid; Glutamic Acid; Gyrus Cinguli; HSP70 Heat-Shock Proteins; Muscimol; Nerve Degeneration; Neural Pathways; Phytohemagglutinins; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Schizophrenia

2000
Haloperidol reverses the changes in striatal glutamatergic immunolabeling following a 6-OHDA lesion.
    Synapse (New York, N.Y.), 2000, Volume: 36, Issue:2

    Topics: Animals; Apomorphine; Denervation; Dopamine Agonists; Dopamine Antagonists; Glutamic Acid; Haloperidol; Immunohistochemistry; Male; Motor Cortex; Neostriatum; Nerve Degeneration; Neural Pathways; Oxidopamine; Parkinsonian Disorders; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Time Factors

2000
Glutamate release and neuronal injury after intrathecal injection of local anesthetics.
    Neuroreport, 2000, Apr-07, Volume: 11, Issue:5

    Topics: Anesthetics, Local; Animals; Anterior Horn Cells; Dose-Response Relationship, Drug; Glutamic Acid; Injections, Spinal; Motor Activity; Nerve Degeneration; Neurotoxins; Rabbits; Tetracaine

2000
Temporal progression of kainic acid induced neuronal and myelin degeneration in the rat forebrain.
    Brain research, 2000, May-02, Volume: 864, Issue:1

    Topics: Amygdala; Animals; Basal Ganglia; Coloring Agents; Denervation; Disease Models, Animal; Epilepsy; Excitatory Amino Acid Agonists; Female; Fluorescent Dyes; Glutamic Acid; Hippocampus; Hypothalamus; Kainic Acid; Myelin Sheath; Nerve Degeneration; Neurons; Neurotoxins; Olfactory Pathways; Parietal Lobe; Phosphates; Prosencephalon; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Status Epilepticus; Thalamus; Time Factors

2000
Intracellular glutathione levels determine cerebellar granule neuron sensitivity to excitotoxic injury by kainic acid.
    Brain research, 2000, Apr-17, Volume: 862, Issue:1-2

    Topics: Animals; Cell Survival; Cerebellum; Excitatory Amino Acid Agonists; Fluoresceins; Glutamic Acid; Glutathione; Kainic Acid; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Oxidative Stress; Radiation-Protective Agents; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species

2000
Caspase-mediated degradation of AMPA receptor subunits: a mechanism for preventing excitotoxic necrosis and ensuring apoptosis.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000, May-15, Volume: 20, Issue:10

    Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Calcium; Caspases; Cell Survival; Cells, Cultured; Excitatory Amino Acid Agonists; Fluorescent Antibody Technique; Glutamic Acid; Hippocampus; N-Methylaspartate; Necrosis; Neocortex; Nerve Degeneration; Nerve Growth Factors; Neurons; Neuroprotective Agents; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Synaptosomes

2000
GABA(A)-mediated toxicity of hippocampal neurons in vitro.
    Journal of neurochemistry, 2000, Volume: 74, Issue:6

    Topics: Animals; Anticonvulsants; Bicuculline; Cell Survival; Cells, Cultured; Epilepsy; Female; Fetus; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; In Vitro Techniques; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Potassium Chloride; Pregnancy; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, GABA-B; Receptors, N-Methyl-D-Aspartate; Vigabatrin

2000
In vivo glutamine hydrolysis in the formation of extracellular glutamate in the injured rat brain.
    Journal of neuroscience research, 2000, Jun-01, Volume: 60, Issue:5

    Topics: Animals; Behavior, Animal; Brain; Brain Injuries; Excitatory Amino Acid Agonists; Extracellular Space; Glutamic Acid; Glutamine; Hydrolysis; Male; Microdialysis; Nerve Degeneration; Neurons; Rats; Rats, Sprague-Dawley; Time Factors

2000
Preconditioning-induced neuroprotection is mediated by reactive oxygen species.
    Brain research, 2000, Jun-02, Volume: 866, Issue:1-2

    Topics: Animals; Cells, Cultured; Chick Embryo; Ferrous Compounds; Free Radical Scavengers; Glutamic Acid; Ischemic Preconditioning; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Reactive Oxygen Species; Staurosporine; Xanthine; Xanthine Oxidase

2000
Protective effect of gamma-glutamylethylamide (theanine) on ischemic delayed neuronal death in gerbils.
    Neuroscience letters, 2000, Aug-11, Volume: 289, Issue:3

    Topics: Animals; Brain Ischemia; Cell Count; Cell Death; Excitatory Amino Acid Antagonists; Gerbillinae; Glutamates; Glutamic Acid; Hippocampus; Nerve Degeneration; Neurons; Neuroprotective Agents; Reperfusion Injury

2000
Ibuprofen protects dopaminergic neurons against glutamate toxicity in vitro.
    Neuroscience letters, 2000, Aug-11, Volume: 289, Issue:3

    Topics: Acetaminophen; Animals; Aspirin; Cell Count; Cells, Cultured; Dopamine; Fetus; Glutamic Acid; Ibuprofen; Mesencephalon; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Parkinson Disease; Rats

2000
Selective activation of mGlu4 metabotropic glutamate receptors is protective against excitotoxic neuronal death.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000, Sep-01, Volume: 20, Issue:17

    Topics: Aminobutyrates; Animals; Cells, Cultured; Cerebral Cortex; Excitatory Amino Acid Agonists; Glutamic Acid; Glycine; Heterozygote; Mice; Mice, Knockout; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Receptors, Metabotropic Glutamate; Stereoisomerism

2000
beta-amyloid neurotoxicity is mediated by a glutamate-triggered excitotoxic cascade in rat nucleus basalis.
    The European journal of neuroscience, 2000, Volume: 12, Issue:8

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Aspartic Acid; Astrocytes; Basal Nucleus of Meynert; Calcium; Calcium Radioisotopes; Cells, Cultured; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Microdialysis; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Rats; Receptors, N-Methyl-D-Aspartate; Taurine

2000
Influence of different anaesthetics on extracellular aminoacids in rat brain.
    Journal of neuroscience methods, 2000, Sep-15, Volume: 101, Issue:2

    Topics: Amino Acids; Anesthetics; Animals; Aspartic Acid; Brain; Brain Chemistry; Brain Ischemia; Extracellular Space; Glutamic Acid; Glycine; Male; Microdialysis; Nerve Degeneration; Neuroprotective Agents; Neurotransmitter Agents; Rats; Rats, Wistar

2000
Acrolein, a product of lipid peroxidation, inhibits glucose and glutamate uptake in primary neuronal cultures.
    Free radical biology & medicine, 2000, Oct-15, Volume: 29, Issue:8

    Topics: Acrolein; Alzheimer Disease; Animals; Biological Transport, Active; Cells, Cultured; Cerebral Cortex; Glucose; Glutamic Acid; Humans; Lipid Peroxidation; Nerve Degeneration; Neurons; Oxidative Stress; Rats

2000
Aluminum enhances glutamate-mediated neurotoxicity in organotypic cultures of rat hippocampus.
    Folia neuropathologica, 2000, Volume: 38, Issue:2

    Topics: Aluminum; Animals; Drug Synergism; Glutamic Acid; Hippocampus; Microscopy, Electron; Mitochondrial Swelling; Nerve Degeneration; Neuropil; Organ Culture Techniques; Pyramidal Cells; Rats; Rats, Wistar

2000
Polyhydroxylated C(60), fullerenols, as glutamate receptor antagonists and neuroprotective agents.
    Journal of neuroscience research, 2000, Nov-15, Volume: 62, Issue:4

    Topics: Animals; Binding Sites; Brain; Calcium; Carbon; Cell Death; Cells, Cultured; Chlorides; Excitatory Amino Acid Antagonists; Female; Ferric Compounds; Fetus; Free Radical Scavengers; Fullerenes; Glutamic Acid; Hydrogen Peroxide; Intracellular Fluid; Nerve Degeneration; Neurons; Neuroprotective Agents; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, GABA; Receptors, Glutamate; Receptors, Neurotransmitter

2000
Hypothermia inhibits ischemia-induced efflux of amino acids and neuronal damage in the hippocampus of aged rats.
    Brain research, 2000, Nov-24, Volume: 884, Issue:1--2

    Topics: Aging; Alanine; Amino Acids; Animals; Aspartic Acid; Brain Ischemia; Cerebrovascular Circulation; Excitatory Amino Acids; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Hippocampus; Hypothermia, Induced; Nerve Degeneration; Neural Inhibition; Neurons; Rats; Rats, Inbred SHR; Taurine

2000
Neuroprotective effects of brain-derived neurotrophic factor in eyes with NMDA-induced neuronal death.
    Brain research, 2000, Nov-24, Volume: 884, Issue:1--2

    Topics: Animals; Brain-Derived Neurotrophic Factor; Cell Count; Cell Death; Fluorescent Dyes; Glutamic Acid; Male; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Retina; Retinal Ganglion Cells; Stilbamidines; Vitreous Body

2000
Seizures and neurodegeneration induced by 4-aminopyridine in rat hippocampus in vivo: role of glutamate- and GABA-mediated neurotransmission and of ion channels.
    Neuroscience, 2000, Volume: 101, Issue:3

    Topics: 4-Aminopyridine; Animals; Epilepsy; Excitatory Amino Acid Antagonists; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Ion Channels; Male; Nerve Degeneration; Neurons; Neurotoxins; omega-Conotoxin GVIA; Potassium Channels; Rats; Rats, Wistar; Receptors, Glutamate; Riluzole; Seizures; Sodium Channel Blockers; Sodium Channels; Synaptic Transmission

2000
Selective vulnerability of pallidal neurons in the early phases of manganese intoxication.
    Experimental brain research, 2000, Volume: 135, Issue:4

    Topics: Animals; Calcium; Calcium Channels; Globus Pallidus; Glutamic Acid; Male; Manganese Poisoning; Nerve Degeneration; Neurons; Parkinsonian Disorders; Patch-Clamp Techniques; Rats; Rats, Wistar

2000
DOPA cyclohexyl ester, a competitive DOPA antagonist, protects glutamate release and resultant delayed neuron death by transient ischemia in hippocampus CA1 of conscious rats.
    Neuroscience letters, 2001, Feb-23, Volume: 299, Issue:3

    Topics: Animals; Brain Ischemia; Cell Death; Dihydroxyphenylalanine; Glutamic Acid; Hippocampus; Levodopa; Male; Nerve Degeneration; Neurons; Neuroprotective Agents; Organ Culture Techniques; Rats; Rats, Wistar; Reperfusion Injury

2001
Ebselen prevents excitotoxicity provoked by glutamate in rat cerebellar granule neurons.
    Neuroscience letters, 2001, Feb-23, Volume: 299, Issue:3

    Topics: Animals; Animals, Newborn; Antioxidants; Azoles; Cell Survival; Cells, Cultured; Cerebellar Cortex; Dose-Response Relationship, Drug; Glutamic Acid; Isoindoles; Lipid Peroxidation; Nerve Degeneration; Neurodegenerative Diseases; Neuroprotective Agents; Neurotoxins; Organoselenium Compounds; Rats; Rats, Wistar

2001
Differential effects of cytokines and redox potential on glutamate uptake in rat cortical glial cultures.
    Neuroscience letters, 2001, Feb-16, Volume: 299, Issue:1-2

    Topics: Amino Acid Transport System X-AG; Animals; Animals, Newborn; ATP-Binding Cassette Transporters; Cell Survival; Cells, Cultured; Cerebral Cortex; Cytokines; Encephalitis; Glutamic Acid; Interleukins; Nerve Degeneration; Neurodegenerative Diseases; Neuroglia; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha

2001
Neuroprotective effects of (+/-)-kavain in the MPTP mouse model of Parkinson's disease.
    Synapse (New York, N.Y.), 2001, Volume: 40, Issue:1

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Anticonvulsants; Brain; Disease Models, Animal; Dopamine; Dopamine Agonists; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Mice; Mice, Inbred C57BL; Neostriatum; Nerve Degeneration; Neurons; Neuroprotective Agents; Parkinsonian Disorders; Pyrones; Substantia Nigra; Tyrosine 3-Monooxygenase

2001
A modified roller method for organotypic brain cultures: free-floating slices of postnatal rat hippocampus.
    Brain research. Brain research protocols, 2001, Volume: 7, Issue:1

    Topics: Animals; Animals, Newborn; Brain Ischemia; Cell Survival; Glutamic Acid; Hippocampus; Histological Techniques; Nerve Degeneration; Neuroglia; Neurons; Organ Culture Techniques

2001
Lubeluzole inhibits accumulation of extracellular glutamate in the hippocampus during transient global cerebral ischemia.
    Brain research, 2001, Apr-20, Volume: 898, Issue:2

    Topics: Action Potentials; Animals; Body Temperature; Brain Ischemia; Cardiovascular Physiological Phenomena; Extracellular Space; Glutamic Acid; Hippocampus; Microdialysis; Nerve Degeneration; Neurons; Neuroprotective Agents; Piperidines; Rabbits; Reperfusion Injury; Respiratory Physiological Phenomena; Thiazoles

2001
17beta-Estradiol reduces cortical lesion size in the glutamate excitotoxicity model by enhancing extracellular lactate: a new neuroprotective pathway.
    Brain research, 2001, May-18, Volume: 901, Issue:1-2

    Topics: Animals; Brain Injuries; Cerebral Cortex; Cerebral Infarction; Disease Models, Animal; Estradiol; Extracellular Space; Glutamic Acid; Hypoxia-Ischemia, Brain; Lactic Acid; Male; Microdialysis; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Rats; Rats, Wistar

2001
Involvement of enhanced sensitivity of N-methyl-D-aspartate receptors in vulnerability of developing cortical neurons to methylmercury neurotoxicity.
    Brain research, 2001, May-18, Volume: 901, Issue:1-2

    Topics: Age Factors; Animals; Animals, Newborn; Antigens, CD; Antigens, Neoplasm; Antigens, Surface; Avian Proteins; Basigin; Blood Proteins; Cerebral Cortex; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Membrane Glycoproteins; Mercury Poisoning, Nervous System; Methylmercury Compounds; Nerve Degeneration; Neurons; Nitrates; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Tyrosine

2001
EAAT1 and EAAT2 immunoreactivity in transgenic mice with a G93A mutant SOD1 gene.
    Neuroreport, 2001, May-25, Volume: 12, Issue:7

    Topics: Aging; Amino Acid Transport System X-AG; Amyotrophic Lateral Sclerosis; Animals; ATP-Binding Cassette Transporters; Disease Models, Animal; Excitatory Amino Acid Transporter 2; Glutamic Acid; Immunohistochemistry; Mice; Mice, Transgenic; Motor Neurons; Mutation; Nerve Degeneration; Posterior Horn Cells; Receptors, Neurotransmitter; Spinal Cord; Superoxide Dismutase; Superoxide Dismutase-1

2001
Nongenomic antiapoptotic signal transduction by estrogen in cultured cortical neurons.
    Journal of neuroscience research, 2001, Jun-01, Volume: 64, Issue:5

    Topics: Alzheimer Disease; Animals; Apoptosis; Cells, Cultured; Cerebral Cortex; Cyclic AMP Response Element-Binding Protein; Enzyme Inhibitors; Estradiol; Estrogen Replacement Therapy; Fetus; Glutamic Acid; Menopause; Nerve Degeneration; Neurons; Neuroprotective Agents; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Serine; Signal Transduction; Staurosporine

2001
Ethanol pre-exposure suppresses HIV-1 glycoprotein 120-induced neuronal degeneration by abrogating endogenous glutamate/Ca2+-mediated neurotoxicity.
    Neuroscience, 2001, Volume: 104, Issue:3

    Topics: AIDS Dementia Complex; Amino Acid Transport System X-AG; Animals; Aspartic Acid; Astrocytes; ATP-Binding Cassette Transporters; Calcium; Drug Interactions; Ethanol; Glial Fibrillary Acidic Protein; Glutamic Acid; Hippocampus; HIV Envelope Protein gp120; Immunohistochemistry; Interleukin-6; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Tritium

2001
Corticotropin-releasing hormone protects neurons against insults relevant to the pathogenesis of Alzheimer's disease.
    Neurobiology of disease, 2001, Volume: 8, Issue:3

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Apoptosis; Calcium; Cells, Cultured; Cerebral Cortex; Corticotropin-Releasing Hormone; Cyclic AMP; Gene Expression; Glucocorticoids; Glutamic Acid; Hippocampus; Homeostasis; Hypothalamo-Hypophyseal System; Lipid Peroxidation; Mice; Mice, Transgenic; Nerve Degeneration; Neurons; Neuroprotective Agents; Oxidative Stress; Pituitary-Adrenal System; Rats; Rats, Sprague-Dawley; RNA, Messenger

2001
The phospholipase A2 inhibitor quinacrine prevents increased immunoreactivity to cytoplasmic phospholipase A2 (cPLA2) and hydroxynonenal (HNE) in neurons of the lateral septum following fimbria-fornix transection.
    Experimental brain research, 2001, Volume: 138, Issue:4

    Topics: Acetylcholine; Aldehydes; Animals; Choline O-Acetyltransferase; Cytoplasm; Enzyme Inhibitors; Fornix, Brain; Glutamic Acid; Immunohistochemistry; Lipid Peroxidation; Male; Microscopy, Electron; Nerve Degeneration; Neurons; Phospholipases A; Phospholipases A2; Quinacrine; Rats; Rats, Wistar; Septal Nuclei; Time Factors; Up-Regulation

2001
Cortical spreading depression and the pathogenesis of brain disorders: a computational and neural network-based investigation.
    Neurological research, 2001, Volume: 23, Issue:5

    Topics: Animals; Brain Ischemia; Calcium; Cell Death; Cerebral Cortex; Cerebrovascular Circulation; Cortical Spreading Depression; Extracellular Space; Glutamic Acid; Hallucinations; Humans; Ion Channels; Membrane Potentials; Migraine Disorders; Models, Neurological; Nerve Degeneration; Neural Networks, Computer; Potassium; Sodium

2001
Post-insult activity is a major cause of delayed neuronal death in organotypic hippocampal slices exposed to glutamate.
    Neuroscience, 2001, Volume: 105, Issue:1

    Topics: Action Potentials; Animals; Brain Injuries; Brain Ischemia; Cell Death; Epilepsy; Glutamic Acid; Hippocampus; Nerve Degeneration; Nerve Net; Neurotoxins; Organ Culture Techniques; Pyramidal Cells; Rats; Tetrodotoxin; Time Factors

2001
Dual effects of interleukin-1beta on N-methyl-D-aspartate-induced retinal neuronal death in rat eyes.
    Brain research, 2001, Aug-10, Volume: 910, Issue:1-2

    Topics: Animals; Cell Death; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Excitatory Amino Acid Agonists; Eye Diseases; Glutamic Acid; Immunohistochemistry; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Male; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Retina; Sialoglycoproteins; Up-Regulation

2001
Calbindin overexpression buffers hippocampal cultures from the energetic impairments caused by glutamate.
    Brain research, 2001, Aug-17, Volume: 911, Issue:1

    Topics: Adenosine Triphosphate; Animals; Calbindin 1; Calbindins; Calcium; Cell Death; Cells, Cultured; Cytosol; Energy Metabolism; Fetus; Genetic Vectors; Glutamic Acid; Membrane Potentials; Mitochondria; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Rats; S100 Calcium Binding Protein G

2001
Decreased MK-801 binding in discrete hippocampal regions of prion-infected mice.
    Neurobiology of disease, 2001, Volume: 8, Issue:4

    Topics: Animals; Autoradiography; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Male; Mice; Mice, Inbred Strains; Nerve Degeneration; Prions; Receptors, N-Methyl-D-Aspartate; Scrapie

2001
Delayed application of IGF-I and GDNF can rescue already injured postnatal motor neurons.
    Neuroreport, 2001, Aug-08, Volume: 12, Issue:11

    Topics: Animals; Cell Count; Cell Survival; Drug Synergism; Glial Cell Line-Derived Neurotrophic Factor; Glutamic Acid; Insulin-Like Growth Factor I; Motor Neurons; Nerve Degeneration; Nerve Growth Factors; Nerve Tissue Proteins; Neurofilament Proteins; Neuroprotective Agents; Organ Culture Techniques; Rats; Spinal Cord; Time Factors

2001
Inhibition of caspase-3-like activity reduces glutamate induced cell death in adult rat retina.
    Brain research, 2001, Jun-15, Volume: 904, Issue:1

    Topics: Animals; Apoptosis; Carbocyanines; Caspase 1; Caspase 3; Caspase Inhibitors; Caspases; Cells, Cultured; Cysteine Proteinase Inhibitors; Dizocilpine Maleate; DNA Fragmentation; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Female; Fluorescent Dyes; Glutamic Acid; In Situ Nick-End Labeling; Nerve Degeneration; Oligopeptides; Rats; Rats, Sprague-Dawley; Retina; Retinal Ganglion Cells

2001
Increased post-traumatic survival of neurons in IL-6-knockout mice on a background of EAE susceptibility.
    Journal of neuroimmunology, 2001, Sep-03, Volume: 119, Issue:1

    Topics: Animals; Cell Survival; Drug Resistance; Encephalomyelitis, Autoimmune, Experimental; Female; Genetic Predisposition to Disease; Glutamic Acid; Interleukin-6; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Crush; Nerve Degeneration; Neurons; Optic Nerve Injuries; Retinal Ganglion Cells

2001
Expressions of nitrotyrosine and TUNEL immunoreactivities in cultured rat spinal cord neurons after exposure to glutamate, nitric oxide, or peroxynitrite.
    Journal of neuroscience research, 2001, Sep-01, Volume: 65, Issue:5

    Topics: Animals; Antioxidants; Apoptosis; Cells, Cultured; Central Nervous System Diseases; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Free Radicals; Glutamic Acid; Immunohistochemistry; In Situ Nick-End Labeling; Interneurons; Motor Neurons; Nerve Degeneration; Neurons; Neurotoxins; Nitrates; Nitric Oxide Donors; Organ Culture Techniques; Oxidative Stress; Rats; Rats, Sprague-Dawley; Spinal Cord; Tyrosine

2001
Post-ischemic administration of DY-9760e, a novel calmodulin antagonist, reduced infarct volume in the permanent focal ischemia model of spontaneously hypertensive rat.
    Neurological research, 2001, Volume: 23, Issue:6

    Topics: Animals; Brain Infarction; Brain Ischemia; Calcium; Calmodulin; Cerebral Cortex; Cerebrovascular Circulation; Disease Models, Animal; Glutamic Acid; Indazoles; Male; Neostriatum; Nerve Degeneration; Neuroprotective Agents; Rats; Rats, Inbred SHR

2001
Propofol and sodium thiopental protect against MK-801-induced neuronal necrosis in the posterior cingulate/retrosplenial cortex.
    Brain research, 2001, Sep-21, Volume: 913, Issue:2

    Topics: Anesthetics, Intravenous; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Female; GABA Agonists; gamma-Aminobutyric Acid; Glutamic Acid; Gyrus Cinguli; Necrosis; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Propofol; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Thiopental

2001
T-cell-based immunity counteracts the potential toxicity of glutamate in the central nervous system.
    Journal of neuroimmunology, 2001, Oct-01, Volume: 119, Issue:2

    Topics: Animals; Autoimmunity; Brain; Dose-Response Relationship, Drug; Ferrous Compounds; Free Radicals; Glutamic Acid; Immunity, Cellular; Mice; Mice, Inbred BALB C; Mice, Nude; Nerve Degeneration; Oxidative Stress; Quaternary Ammonium Compounds; Retina; Spleen; T-Lymphocytes; Transplants

2001
Different dynamic patterns of extracellular glutamate release in rat hippocampus after permanent or 30-min transient cerebral ischemia and histological correlation.
    Neuropathology : official journal of the Japanese Society of Neuropathology, 2001, Volume: 21, Issue:3

    Topics: Animals; Astrocytes; Brain; Brain Ischemia; Extracellular Space; Glutamic Acid; Hippocampus; Male; Microdialysis; Necrosis; Nerve Degeneration; Neurons; Rats; Rats, Wistar; Reperfusion Injury; Up-Regulation

2001
Neurotoxicity of glutamate uptake inhibition in vivo: correlation with succinate dehydrogenase activity and prevention by energy substrates.
    Neuroscience, 2001, Volume: 106, Issue:4

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Amino Acid Transport System X-AG; Animals; Brain Ischemia; Convulsants; Creatine; Dicarboxylic Acids; Drug Interactions; Energy Metabolism; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Neostriatum; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Neurotransmitter Uptake Inhibitors; Nitro Compounds; Propionates; Pyrrolidines; Pyruvic Acid; Rats; Rats, Wistar; Succinate Dehydrogenase

2001
Neuroprotective actions in vivo and electrophysiological actions in vitro of 202W92.
    Brain research, 2001, Nov-23, Volume: 919, Issue:2

    Topics: Animals; Brain Ischemia; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Cerebral Infarction; Dose-Response Relationship, Drug; Excitatory Postsynaptic Potentials; Glutamic Acid; Infarction, Middle Cerebral Artery; Male; Membrane Potentials; Nerve Degeneration; Neurons; Neuroprotective Agents; Patch-Clamp Techniques; Pyrimidines; Rats; Rats, Inbred F344; Sodium Channel Blockers; Sodium Channels; Substantia Nigra; Synaptic Transmission; Telencephalon

2001
The POU domain transcription factor Brn-3a protects cortical neurons from apoptosis.
    Neuroreport, 2001, Oct-29, Volume: 12, Issue:15

    Topics: Animals; Animals, Newborn; Apoptosis; Camptothecin; Cell Survival; Cerebral Cortex; DNA-Binding Proteins; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Genetic Therapy; Genetic Vectors; Glutamic Acid; Green Fluorescent Proteins; Immunohistochemistry; Indicators and Reagents; Luminescent Proteins; Nerve Degeneration; Neurons; Neurotoxins; Protein Structure, Tertiary; Rats; Rats, Sprague-Dawley; Simplexvirus; Staurosporine; Transcription Factor Brn-3; Transcription Factors

2001
Prevention of neurotoxin damage of 6-OHDA to dopaminergic nigral neuron by subthalamic nucleus lesions.
    Stereotactic and functional neurosurgery, 2000, Volume: 75, Issue:2-3

    Topics: Afferent Pathways; Animals; Biomarkers; Dopamine; Excitatory Amino Acid Agonists; Glutamic Acid; Kainic Acid; Male; Medial Forebrain Bundle; Microinjections; Nerve Degeneration; Nerve Tissue Proteins; Neurons; Neurotoxins; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Wistar; Substantia Nigra; Subthalamic Nucleus; Tyrosine 3-Monooxygenase; Ventral Tegmental Area

2000
Role of taurine in regulation of intracellular calcium level and neuroprotective function in cultured neurons.
    Journal of neuroscience research, 2001, Nov-15, Volume: 66, Issue:4

    Topics: Animals; Brain; Brain Diseases; Calcium; Cells, Cultured; Drug Interactions; Female; Glutamic Acid; Homeostasis; Intracellular Fluid; L-Lactate Dehydrogenase; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Taurine; Tritium

2001
Lactate reduces glutamate-induced neurotoxicity in rat cortex.
    Journal of neuroscience research, 2001, Dec-01, Volume: 66, Issue:5

    Topics: Animals; Brain Injuries; Cerebral Cortex; Drug Interactions; Extracellular Space; Glucose; Glutamic Acid; Immunohistochemistry; Isomerism; Lactic Acid; Male; Microdialysis; Microtubule-Associated Proteins; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Rats; Rats, Inbred Strains

2001
Polyamine metabolism and glutamate receptor agonists-mediated excitotoxicity in the rat brain.
    Journal of neuroscience research, 2001, Dec-15, Volume: 66, Issue:6

    Topics: Animals; Biogenic Polyamines; Biomarkers; Body Weight; Brain; Disease Models, Animal; Epilepsy; Excitatory Amino Acid Agonists; Frontal Lobe; Functional Laterality; Glutamic Acid; Hippocampus; Injections, Intraventricular; Male; Nerve Degeneration; Neurons; Neurotoxins; Putrescine; Rats; Rats, Wistar; Receptors, Glutamate; Spermidine; Spermine

2001
In vivo cellular uptake of glutamate is impaired in the rat hippocampus during and after transient cerebral ischemia: a microdialysis extraction study.
    Journal of neuroscience research, 2001, Dec-15, Volume: 66, Issue:6

    Topics: Animals; Aspartic Acid; Brain Ischemia; Carrier Proteins; Enzyme Inhibitors; Extracellular Space; Glutamic Acid; Hippocampus; Male; Microdialysis; Nerve Degeneration; Presynaptic Terminals; Rats; Rats, Wistar; Synaptic Transmission; Tritium

2001
Endothelin downregulates the glutamate transporter GLAST in cAMP-differentiated astrocytes in vitro.
    Glia, 2002, Volume: 37, Issue:2

    Topics: Actin Cytoskeleton; Amino Acid Transport System X-AG; Animals; Animals, Newborn; Astrocytes; Brain Injuries; Bucladesine; Cell Differentiation; Cell Size; Cells, Cultured; Down-Regulation; Endothelin Receptor Antagonists; Endothelins; Glial Fibrillary Acidic Protein; Glutamic Acid; Immunohistochemistry; Nerve Degeneration; Rats; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin

2002
Nitric oxide-mediated Ca++-influx in neuronal nuclei and cortical synaptosomes of normoxic and hypoxic newborn piglets.
    Neuroscience letters, 2002, Jan-25, Volume: 318, Issue:2

    Topics: Adenosine Triphosphate; Animals; Asphyxia Neonatorum; Calcium; Calcium Signaling; Cell Nucleus; Cerebral Cortex; Free Radicals; Glutamic Acid; Glycine; Humans; Hypoxia, Brain; Infant, Newborn; Nerve Degeneration; Neurons; Nitric Oxide; Nitric Oxide Donors; Oxidative Stress; Peroxynitrous Acid; Phosphocreatine; Receptors, N-Methyl-D-Aspartate; Swine; Synaptosomes

2002
Dopamine D2 receptor signaling controls neuronal cell death induced by muscarinic and glutamatergic drugs.
    Molecular and cellular neurosciences, 2002, Volume: 19, Issue:2

    Topics: Acetylcholine; Animals; Behavior, Animal; Cell Death; Dose-Response Relationship, Drug; Epilepsy; Excitatory Amino Acid Agonists; Female; Genotype; Glutamic Acid; Kainic Acid; Limbic System; Male; Mice; Mice, Knockout; Molecular Sequence Data; Muscarinic Agonists; Nerve Degeneration; Pilocarpine; Receptors, Dopamine D2; Receptors, Muscarinic; RNA, Messenger; Signal Transduction; Synaptic Transmission

2002
Aspirin inhibits stress-induced increase in plasma glutamate, brain oxidative damage and ATP fall in rats.
    Neuroreport, 2002, Feb-11, Volume: 13, Issue:2

    Topics: Adenosine Triphosphate; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain; Cerebral Cortex; Glutamic Acid; Immobilization; Male; Nerve Degeneration; Neuroprotective Agents; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidation-Reduction; Rats; Rats, Wistar; Reference Values; Stress, Physiological; Tumor Necrosis Factor-alpha

2002
Differential susceptibility to ageing of rat preganglionic neurones projecting to the major pelvic ganglion and of their afferent inputs.
    Autonomic neuroscience : basic & clinical, 2002, Feb-28, Volume: 96, Issue:1

    Topics: Afferent Pathways; Aging; Animals; Dendrites; Disease Susceptibility; Efferent Pathways; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Hypogastric Plexus; Immunohistochemistry; Male; Microscopy, Electron; Nerve Degeneration; Neural Pathways; Parasympathetic Nervous System; Presynaptic Terminals; Rats; Rats, Wistar; Serotonin; Spinal Cord; Sympathetic Nervous System; Thyrotropin-Releasing Hormone

2002
Arctigenin protects cultured cortical neurons from glutamate-induced neurodegeneration by binding to kainate receptor.
    Journal of neuroscience research, 2002, Apr-15, Volume: 68, Issue:2

    Topics: Animals; Cells, Cultured; Cerebral Cortex; Free Radical Scavengers; Furans; Glutamic Acid; Kainic Acid; Lignans; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Peroxides; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid

2002
Downregulation of kainate receptors in the hippocampus following repeated seizures in immature rats.
    Brain research. Developmental brain research, 2002, Jun-30, Volume: 136, Issue:2

    Topics: Animals; Animals, Newborn; Binding Sites; Down-Regulation; Drug Administration Schedule; Epilepsy; Excitatory Amino Acid Agonists; Female; Glutamic Acid; Hippocampus; Kainic Acid; Learning; Male; Memory; Nerve Degeneration; Neurons; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; Synaptic Transmission

2002
beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1992, Volume: 12, Issue:2

    Topics: Amino Acid Sequence; Amyloid beta-Peptides; Calcimycin; Calcium; Cell Survival; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Fetus; Glutamates; Glutamic Acid; Homeostasis; Humans; Indicators and Reagents; Kinetics; Molecular Sequence Data; Nerve Degeneration; Neurons; Peptide Fragments; Structure-Activity Relationship

1992
A dose-dependent increase of Tau immunostaining is produced by glutamate toxicity in primary neuronal cultures.
    Brain research, 1992, Feb-14, Volume: 572, Issue:1-2

    Topics: Alzheimer Disease; Animals; Cells, Cultured; Cerebral Cortex; Glutamates; Glutamic Acid; Immunohistochemistry; Nerve Degeneration; Neurons; Rats; tau Proteins

1992
Synaptic and nonsynaptic determinants of excitability changes in aluminum-intoxicated rabbit CA1 pyramidal neurons studied in vitro.
    Epilepsy research. Supplement, 1992, Volume: 8

    Topics: Aluminum; Aluminum Chloride; Aluminum Compounds; Animals; Chlorides; Culture Techniques; Dose-Response Relationship, Drug; Evoked Potentials; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hippocampus; N-Methylaspartate; Nerve Degeneration; Neurofibrils; Neurons; Rabbits; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission

1992
Intrahippocampal tetanus toxin produces generalized convulsions and neurodegeneration in rats: antagonism by NMDA receptor blockers.
    Epilepsy research. Supplement, 1992, Volume: 9

    Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Carbamazepine; Diazepam; Dizocilpine Maleate; Epilepsy, Generalized; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hippocampus; Male; Nerve Degeneration; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Tetanus Toxin

1992
Neuronal loss or replacement in the injured adult cerebral neocortex induces extensive remodeling of intrinsic and afferent neural systems.
    Experimental neurology, 1992, Volume: 117, Issue:2

    Topics: Afferent Pathways; Analysis of Variance; Animals; Axonal Transport; Cerebral Cortex; Choline O-Acetyltransferase; Female; Glutamate Decarboxylase; Glutamates; Glutamic Acid; Kainic Acid; N-Methylaspartate; Nerve Degeneration; Nerve Regeneration; Neurons; Neurotoxins; Norepinephrine; Rats; Rats, Inbred Strains; Serotonin; Sympathectomy

1992
A case of adult onset pure pallidal degeneration. II. Analysis of neurotransmitter markers, with special reference to the termination of pallidothalamic tract in human brain.
    Journal of the neurological sciences, 1991, Volume: 102, Issue:1

    Topics: Adult; Aged; Basal Ganglia Diseases; Biomarkers; Brain Chemistry; Choline O-Acetyltransferase; Female; gamma-Aminobutyric Acid; Globus Pallidus; Glutamates; Glutamic Acid; Humans; Male; Middle Aged; Movement Disorders; Nerve Degeneration; Neurotransmitter Agents; Norepinephrine; Thalamus

1991
Excitotoxicity in the embryonic chick spinal cord.
    Annals of neurology, 1991, Volume: 30, Issue:6

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids, Diamino; Animals; beta-Alanine; Chick Embryo; Cyanobacteria Toxins; Dizocilpine Maleate; Glutamates; Glutamic Acid; Ibotenic Acid; Kainic Acid; Motor Neurons; N-Methylaspartate; Nerve Degeneration; Neurotoxins; Quinoxalines; Quisqualic Acid; Spinal Cord

1991
Various Ca2+ entry blockers prevent glutamate-induced neurotoxicity.
    European journal of pharmacology, 1991, Dec-17, Volume: 209, Issue:3

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Calcium Channel Blockers; Cerebellum; Dihydropyridines; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Ibotenic Acid; Isradipine; Kainic Acid; Nerve Degeneration; Nervous System Diseases; Nifedipine; Rats; Rats, Inbred Strains; Verapamil

1991
Masking effect of NMDA receptor antagonists on the formation of long-term potentiation (LTP) in superior colliculus slices from the guinea pig.
    Brain research, 1990, Jun-04, Volume: 518, Issue:1-2

    Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Denervation; Dibenzocycloheptenes; Dipeptides; Dizocilpine Maleate; Evoked Potentials; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; In Vitro Techniques; Kynurenic Acid; Magnesium; Mice; Nerve Degeneration; Optic Nerve; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Superior Colliculi; Visual Cortex

1990
Ante mortem cerebral amino acid concentrations indicate selective degeneration of glutamate-enriched neurons in Alzheimer's disease.
    Neuroscience, 1990, Volume: 38, Issue:3

    Topics: Alzheimer Disease; Amino Acids; Brain; Glutamates; Glutamic Acid; Humans; Male; Middle Aged; Nerve Degeneration; Neurons; Osmolar Concentration; Postmortem Changes

1990
The role of taurine and glutamate during early postnatal cerebellar development of normal and weaver mutant mice.
    Advances in experimental medicine and biology, 1990, Volume: 268

    Topics: Animals; Astrocytes; Cerebellum; Glutamates; Glutamic Acid; In Vitro Techniques; Mice; Mice, Neurologic Mutants; Nerve Degeneration; Nervous System Diseases; Proto-Oncogenes; RNA, Messenger; Taurine

1990
Roles for mitotic history in the generation and degeneration of hippocampal neuroarchitecture.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1989, Volume: 9, Issue:4

    Topics: Animals; Biomechanical Phenomena; Calcium; Cell Line; Glutamates; Glutamic Acid; Hippocampus; Mitosis; Nerve Degeneration; Neurons

1989
"Epileptic" brain damage is replicated qualitatively in the rat hippocampus by central injection of glutamate or aspartate but not by GABA or acetylcholine.
    Brain research bulletin, 1985, Volume: 15, Issue:1

    Topics: Acetylcholine; Animals; Aspartic Acid; Brain; Disease Models, Animal; Epilepsy; gamma-Aminobutyric Acid; Glial Fibrillary Acidic Protein; Glutamates; Glutamic Acid; Hippocampus; Immunoenzyme Techniques; Injections, Intraventricular; Male; Motor Activity; Nerve Degeneration; Rats; Rats, Inbred Strains; Time Factors

1985
Changes in neurobiological parameters in the hippocampus after exposure to trimethyltin.
    Neurotoxicology, 1985,Fall, Volume: 6, Issue:3

    Topics: Animals; Brain; Electroencephalography; Glutamates; Glutamic Acid; Hippocampus; Injections; Male; Nerve Degeneration; Pyramidal Tracts; Rats; Rats, Inbred Strains; Time Factors; Trialkyltin Compounds; Trimethyltin Compounds

1985
Amino acid levels in the guinea pig spinal gray matter after axotomy of primary sensory and descending tracts.
    Journal of neurochemistry, 1986, Volume: 47, Issue:2

    Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Axons; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Guinea Pigs; Nerve Degeneration; Neural Pathways; Neurons, Afferent; Spinal Cord; Spinal Nerve Roots

1986
Seizures and brain damage: are excitatory amino acids involved?
    Advances in experimental medicine and biology, 1986, Volume: 203

    Topics: Action Potentials; Amino Acids; Animals; Brain; Epilepsy; Glutamates; Glutamic Acid; Hippocampus; Nerve Degeneration; Neurotransmitter Agents; Quinolinic Acid; Quinolinic Acids; Seizures; Synaptic Transmission

1986
Glutamate neurotoxicity in cortical cell culture.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1987, Volume: 7, Issue:2

    Topics: Animals; Cell Count; Cells, Cultured; Cerebral Cortex; Glial Fibrillary Acidic Protein; Glutamates; Glutamic Acid; Histocytochemistry; Immunoenzyme Techniques; Kainic Acid; Membrane Potentials; Mice; Nerve Degeneration

1987
Glutamatergic denervation in Alzheimer's disease--a cautionary note.
    Journal of neurology, neurosurgery, and psychiatry, 1987, Volume: 50, Issue:6

    Topics: Alzheimer Disease; Aspartic Acid; Brain; Glutamates; Glutamic Acid; Humans; Nerve Degeneration

1987
The effects of cortical ablation on multiple unit activity in the striatum following dexamphetamine.
    Neuropharmacology, 1987, Volume: 26, Issue:8

    Topics: Animals; Behavior, Animal; Cerebral Cortex; Corpus Striatum; Dextroamphetamine; Electrophysiology; Enkephalin, Methionine; Glutamates; Glutamic Acid; Haloperidol; Male; Nerve Degeneration; Neurons, Afferent; Rats

1987
Cytotoxic properties of glutamate and aspartate in rat peripheral nerves: histological findings.
    Neuroscience letters, 1987, Oct-16, Volume: 81, Issue:1-2

    Topics: Animals; Aspartic Acid; Female; Glutamates; Glutamic Acid; Male; Nerve Degeneration; Rats; Rats, Inbred Strains; Sciatic Nerve

1987
Evidence for reactive synaptogenesis in the ventrolateral thalamus and red nucleus of the rat: changes in high affinity glutamate uptake and numbers of corticofugal fiber terminals.
    Experimental brain research, 1987, Volume: 69, Issue:1

    Topics: Animals; Cerebellar Nuclei; Cerebral Cortex; Cerebral Decortication; Glutamates; Glutamic Acid; Kainic Acid; Male; Nerve Degeneration; Neuronal Plasticity; Rats; Rats, Inbred Strains; Red Nucleus; Thalamic Nuclei

1987
Changes in the content of glutamate and GABA in the cerebellar vermis and hemispheres of the Purkinje cell degeneration (pcd) mutant.
    Neurochemical research, 1988, Volume: 13, Issue:2

    Topics: Alanine; Animals; Cerebellum; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Mice; Mice, Inbred C57BL; Mice, Neurologic Mutants; Nerve Degeneration; Purkinje Cells; Reference Values

1988