glutamic acid has been researched along with Injury, Ischemia-Reperfusion in 186 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 26 (13.98) | 18.2507 |
| 2000's | 86 (46.24) | 29.6817 |
| 2010's | 60 (32.26) | 24.3611 |
| 2020's | 14 (7.53) | 2.80 |
| Authors | Studies |
|---|---|
| Gupta, S; Kumar, M; Kushwah, AS; Singh, G; Singh, TG; Surampalli, G | 1 |
| Azami Tameh, A; Karimian, M; Khassafi, N; Vahidinia, Z; Zahraei, Z | 1 |
| Wang, F; Zhang, X; Zhou, H | 1 |
| El-Sahar, AE; Khattab, MA; Mohammed, RA; Saad, MA; Sayed, RH | 1 |
| Ghatage, T; Mardhekar, V; Prakash, A; Sarode, LP; Ugale, RR; Verma, B | 1 |
| Kurian, GA; Ravindran, S | 1 |
| Almeida, A; Bolaños, JP; Burmistrova, O; Eremeeva, T; Fedichev, PO; Jimenez-Blasco, D; Lapresa, R; Olias-Arjona, A; Romanov, S; Shishov, D; Zakurdaeva, K | 1 |
| Diao, K; Han, L; Jia, X; Li, M; Tian, G; Yang, Z; Zhang, M | 1 |
| Wei, W; Yue, Y; Zhang, Y; Zhao, H | 1 |
| Fujimoto, Y; Funao, T; Kimura, A; Mori, T; Mukai, A; Nishikawa, K; Suehiro, K | 1 |
| Gakare, S; Kumar, R; Mahale, A; Prakash, A; Sarode, LP; Ugale, RR | 1 |
| Gu, Y; Jiang, C; Ren, K; Wang, L; Yao, Q | 1 |
| Chen, HY; Lin, CH; Wei, KC | 1 |
| Bian, Q; Gao, Z; Li, Y; Liu, Z; Ma, D; Zhang, S; Zhang, Z | 1 |
| Liu, L; Sheng, R; Tan, J; Xie, F; Yuan, Q; Yuan, Y; Zheng, Y | 1 |
| Asada, M; Hayashi, H; Horinokita, I; Iwatani, Y; Liu, JX; Takagi, N; Wang, M | 1 |
| Cheng, G; Huang, M; Qin, R; Tan, H; Wang, Y; Zhang, Y; Zou, Y | 1 |
| Chen, J; Feng, H; Hu, R; Jin, P; Lei, R; Liao, H; Wan, Q; Wan, Y; Zhang, Y; Zhang, Z; Zhuang, Y | 1 |
| Choi, CG; Choi, Y; Ha, HK; Ham, SJ; Jeon, SB; Jung, SC; Kim, J; Kim, JK; Kim, KW; Kim, ST; Kwon, JI; Shim, WH; Sung, YS; Woo, CW; Woo, DC | 1 |
| Cao, L; Cao, ZY; Hu, HF; Luo, YP; Wang, ZZ; Xiao, W; Zhang, H; Zhang, XZ | 1 |
| Gong, Y; Guo, F; Sun, X; Xu, L; Zhang, M | 1 |
| Feng, J; Feng, L; Ma, D; Xin, M; You, J | 1 |
| Atkin, SL; Butler, AE; Sahebkar, A; Zendedel, E | 1 |
| Diao, Y; Li, J; Luo, Y; Sun, W; Yan, W; Yin, Y | 1 |
| Bona, M; Bonova, P; Gottlieb, M; Jachova, J; Macakova, L; Nemethova, M | 1 |
| Chen, L; Han, P; Huang, J; Lin, J; Lin, Z; Peng, J; Tao, J; Xu, W; Xue, X; Yang, S | 1 |
| Arora, S; Kaur, T; Pundir, M; Singh, AP; Singh, R | 1 |
| Ji, XL; Tian, F; Tian, LJ; Xu, LH; Zhao, W | 1 |
| Bordone, M; Chianelli, M; Dorfman, D; González Fleitas, MF; Rosenstein, RE; Salido, EM | 1 |
| Andreescu, S; Ganesana, M; Ispas, C; Leiter, JC; Özel, RE | 1 |
| Chen, HZ; Cui, YY; Feng, XM; Li, H; Qiu, Y; Tan, PP; Yuan, HH; Zhou, W; Zhu, X | 1 |
| Lei, RY; Liu, YR; Lu, H; Wang, CE; Zhang, BA; Zhang, GB; Zhu, HC | 1 |
| Bo, F; Fu, J; Liu, W; Wang, D | 1 |
| Chen, L; Chen, X; Chu, K; Huang, M; Li, H; Xu, W; Zhang, Y | 1 |
| Makarova, LM; Mirzoian, RS; Pogorelyĭ, VE; Prikhod'ko, MA; Skachilova, SIa | 1 |
| Anuncibay-Soto, B; Fernández-López, A; Llorente, IL; Pérez-García, CC; Pérez-Rodríguez, D | 1 |
| Bie, XD; Ge, LJ; Han, J; Wan, HT; Yang, JH; Zhang, YY | 1 |
| Teng, F; Tu, J; Zhang, C; Zhang, D | 1 |
| Ambrósio, AF; Coreixas, VS; Domith, I; Loiola, EC; Martins, T; Oliveira, NA; Paes-de-Carvalho, R; Portugal, CC; Relvas, JB; Santiago, AR; Socodato, R | 1 |
| Abdel Salam, RM; Attia, AS; Kenawy, SA; Saad, MA | 1 |
| Carpanese, E; Crema, F; Filpa, V; Frigo, G; Giaroni, C; Lecchini, S; Marchet, S; Moro, E; Prandoni, V | 1 |
| Abdelsalam, RM; Attia, AS; Kenawy, SA; Saad, MA | 1 |
| Abbruscato, TJ; Islam, MR; Karamyan, VT; Yang, L | 1 |
| Battaile, K; Cooper, AJ; Jeitner, TM | 1 |
| Ain-Shoka, AA; Attia, AS; El-Sahar, AE; Safar, MM; Zaki, HF | 1 |
| Bradamante, V; Kelava, M; Konjevoda, P; Lovrić, J; Macan, M; Štambuk, N; Vrkić, N; Vukšić, A; Žunec, S | 1 |
| Liu, B; Lou, Z; Luo, XJ; Peng, J; Peng, JJ; Ren, KD; Ren, X; Tan, B; Xiong, XM; Yang, ZB; Zhang, XJ | 1 |
| Gao, F; Li, P; Shen, M; Teng, F; Wu, J; Zhang, C; Zhang, J | 1 |
| Abdul, KK; Justin, A; Ramanathan, M | 1 |
| Bracco, F; Brizi, C; Budriesi, R; Chiarini, A; De Cristofaro, A; Del Genio, A; di Perna, I; Frosini, M; Micucci, M; Pepe, GL; Santulli, C | 1 |
| Chen, J; Guan, QH; Han, D; Hou, XY; Jiang, HX; Li, C; Liu, XM; Pei, DS; Wang, XT; Wen, XR; Zhang, GY | 1 |
| Du, Y; Hirooka, K; Itano, T; Miyamoto, O; Shiraga, F; Tokuda, M | 1 |
| Biswal, S; Christen, Y; Doré, S; Saleem, S; Zhuang, H | 1 |
| Cohen, GA; Hyyti, OM; Isern, N; Ning, XH; Olson, AK; Portman, MA; Sadilek, M | 1 |
| Bagetta, G; Cavaliere, F; Cerulli, A; Corasaniti, MT; Fazzi, E; Gliozzi, M; Morrone, LA; Nucci, C; Rombolà, L; Russo, R | 1 |
| Bouitbir, J; Chakfe, N; Di Marco, P; Geny, B; Kretz, JG; Piquard, F; Ribera, F; Thaveau, F; Zoll, J | 1 |
| Burda, J; Danielisova, V; Gottlieb, M; Kravcukova, P; Nemethova, M | 2 |
| Ma, N; Sasoh, M; Uji, Y | 1 |
| Bagetta, G; Bucci, MG; Corasaniti, MT; Morrone, LA; Nucci, C; Rotiroti, D; Russo, R; Tassorelli, C | 1 |
| Aki, HS; Aoki, T; Fujimoto, K; Fujita, M; Kasaoka, S; Kumagai, K; Maekawa, T; Maruyama, I; Murata, H; Nanba, M; Tsuruta, R; Yamashita, S; Yuasa, M | 1 |
| Bei, W; Good, DA; Guo, J; Hu, D; Hu, Y; Li, C; Peng, W; Wei, M; Wu, W; Xu, A; Zang, L; Zhu, X | 1 |
| Chianelli, MS; Fernandez, DC; Rosenstein, RE | 1 |
| Frosini, M; Ricci, L; Sgaragli, G; Valoti, M | 1 |
| Baumgartner, WA; Blue, ME; Brock, MV; Johnston, MV; Lange, MS; Lowenstein, CJ; Troncoso, JC; Tseng, EE | 1 |
| Akira, S; Hirayama, Y; Ikeda-Matsuo, Y; Ota, A; Sasaki, Y; Uematsu, S | 1 |
| Chae, SJ; Choi, S; Choi, SK; Chung, JH; Kang, SW; Lee, GJ; Park, HK | 1 |
| Andrabi, SA; Dawson, TM; Dawson, VL; Kibler, KK; Klaus, JA; Koehler, RC; Li, X; Rao, K; Xu, Z; Yang, ZJ; Zhang, J | 1 |
| Alborch, E; Arce, C; Burguete, MC; Cañadas, S; Castelló-Ruiz, M; González, MP; Oset-Gasque, MJ; Roncero, C; Salom, JB; Sánchez-Mendoza, E; Torregrosa, G | 1 |
| Mishra, V; Raghubir, R; Sasmal, D; Verma, R | 1 |
| Barnett, NL; Gole, GA; Holcombe, DJ | 1 |
| Cao, ZJ; Guo, QC; Hu, YS; Jia, J; Liu, G; Wu, Y; Xia, CM; Yu, HX; Zhang, X; Zhu, DN | 1 |
| Chae, SJ; Choi, S; Choi, SK; Jin Joo, H; Kang, SW; Lee, GJ; Park, E; Park, HK | 1 |
| Shang, Y | 1 |
| Feng, W; Li, J; Li, SX; Wang, H; Yang, ZZ | 1 |
| Bromberg, Y; Navon, H; Shani, E; Sperling, O | 1 |
| Bae, K; Hwang, BY; Jeong, HY; Kim, JY; Kim, S; Lee, HK; Seong, YH | 1 |
| Gu, PF; Li, Y; Shang, Y | 1 |
| Bromberg, Y; Sperling, O; Sragovich, S; Zoref-Shani, E | 1 |
| Jin, GR; Wang, JH; Zhang, HJ; Zhao, LD; Zhao, Y | 1 |
| Chen, Y; Ding, J; Guo, LJ; Sun, X; Zhan, JJ; Zhao, B; Zhou, M | 1 |
| Donaldson, P; Hu, RG; Kalloniatis, M; Zhu, Y | 1 |
| Borgens, RB; Liu-Snyder, P | 1 |
| Babu, CS; Justin, A; Ramanathan, M; Shanthakumari, S | 1 |
| Fei, SJ; Li, TT; Li, Y; Liu, ZB; Qiao, X; Zhang, JF; Zhu, JZ; Zhu, SP | 1 |
| Aldinucci, C; Contartese, A; Corelli, F; Frosini, M; Mugnaini, C; Pasquini, S; Pessina, F; Sgaragli, G; Valoti, M | 1 |
| Bellver-Landete, V; González, MP; Martínez-Murillo, R; Merino, JJ; Oset-Gasque, MJ; Sánchez-Mendoza, E | 1 |
| Bian, X; Chen, S; Hu, Z; Liu, X; Wang, K; Wang, Y; Zhang, X; Zhu, Y | 1 |
| Yan, CD; Zhang, JF; Zhang, YM; Zhou, XP | 1 |
| Chandrasekaran, K; Chinopoulos, C; Drieu, K; Fiskum, G; Mehrabian, Z; Spinnewyn, B | 1 |
| Adam-Vizi, V; Tretter, L | 1 |
| Goto, W; Hara, H; Kawazu, K; Miyawaki, N; Morikawa, N; Ota, T; Otori, Y; Tano, Y | 1 |
| Du, GY; Fu, JH | 1 |
| An, SJ; Cho, SS; Hwang, IK; Kang, TC; Lee, YB; Moon, SM; Park, SK; Sohn, HS; Won, MH; Yoon, DK | 1 |
| Inoue-Matsuhisa, E; Mano, T; Mizota, A; Sogo, S; Takenaka, H; Taniai, M | 1 |
| Chen, M; Guo, G; He, M; Jiang, X; Wang, J; Zhang, M; Zheng, Y | 1 |
| King, N; Lin, H; McGivan, JD; Suleiman, MS | 1 |
| Caccamo, D; Calapai, G; Campisi, A; Currò, M; Ientile, R; Mannucci, C; Marciano, MC | 1 |
| Castagnetta, M; Cervetto, C; Marcoli, M; Maura, G; Sbaffi, P | 1 |
| Ralphe, JC; Scholz, TD; Schutte, BC; Segar, JL | 1 |
| Büyükuysal, RL | 1 |
| Bonfanti, A; Chiaramonte, G; Marcoli, M; Maura, G; Ongini, E; Raiteri, M; Roccatagliata, P | 1 |
| Biedermann, B; Bringmann, A; Iandiev, I; Pannicke, T; Perlman, I; Reichenbach, A; Uckermann, O; Wiedemann, P | 1 |
| Helps, SC; Nilsson, M; Sims, NR; Thoren, AE | 2 |
| Dunbar, JC; Levy, J; Zhu, Z | 1 |
| Dohmen, C; Graf, R; Heiss, WD; Kumura, E; Rosner, G | 1 |
| Chatham, JC; Lloyd, SG; Wang, P | 1 |
| Blanc, MC; Bonnefont-Rousselot, D; Cynober, L; De Bandt, JP; Genthon, C; Le Tourneau, A; Schuster, H; Thérond, P | 1 |
| Du, GH; Gong, PL; Li, Z; Lin, XM; Zeng, FD | 1 |
| Bagetta, G; Fazzi, E; Morrone, LA; Nucci, C; Rombolà, L; Tartaglione, R | 1 |
| Canolle, B; Guillet, B; Labrande, C; Masmejean, F; Nieoullon, A; Pisano, P; Velly, L | 1 |
| Lee, SM; Lee, WY | 1 |
| Bainy, AC; Brongholi, K; Dafre, AL; Souza, DG; Tasca, CI | 1 |
| Baba, T; Du, Y; Hirooka, K; Itano, T; Jinming, P; Miyamoto, O; Shiraga, F; Tokuda, M | 1 |
| Ben-Ari, Y; Bihi, RI; Crépel, V; Epsztein, J; Jorquera, I; Milh, M; Represa, A | 1 |
| Kaminska, B; Szydlowska, K; Zawadzka, M | 1 |
| Barger, SW; Mao, X; Simpkins, JW; Yang, SH | 1 |
| Arab, HA; Cheung, K; Hickman, PE; Kadkhodaee, M; Potter, JM; Roberts, MS | 1 |
| Fiskum, G; Hopkins, I; McKenna, MC; Richards, EM; Rosenthal, RE | 1 |
| Brorson, JR; Li, D; Shao, Z; Vanden Hoek, TL | 1 |
| Cheung, AK; Chung, SK; Chung, SS; Lo, AC; So, KF | 1 |
| Esquivel, CO; Krams, SM; Lopez, J; Martinez, OM; Nagasaki, K; Riddle-Taylor, E | 1 |
| Liu, J; Ma, H; Wang, C; Zhang, D | 1 |
| Bringmann, A; Pannicke, T; Reichenbach, A; Wiedemann, P; Wurm, A | 1 |
| Akaike, A; Kihara, T; Niidome, T; Nishimoto, T; Sugimoto, H | 1 |
| Chen, Q; Hoppel, CL; Lesnefsky, EJ; Moghaddas, S | 1 |
| Chou, YC; Liao, JF; Liou, KT; Shen, YC; Wang, WY; Wang, YH; Yen, JC | 1 |
| Chen, CF; Chien, CT; Ma, MC; Wu, MH; Yang, CC | 1 |
| Barnstable, CJ; Fu, XY; Kawasaki, A; Li, H; Liu, MG; Shao-Min Zhang, S; Zhang, C | 1 |
| O'Regan, MH; Perkins, LM; Phillis, JW | 1 |
| Aihara, K; Goto, N; Kamata, T; Matsumoto, Y | 1 |
| Gaspary, HL; Graham, SH; Simon, RP | 1 |
| Calinon, F; Delbarre, B; Delbarre, G | 1 |
| Beek, O; Cooper, BR; Dickerson, MC; Norton, R; Wiard, RP | 1 |
| Allen, BT; Davis, CG; Karl, I; Osborne, D | 1 |
| Bonne, C; Cazevieille, C; Meynier, F; Muller, A | 1 |
| Halpern, EF; Lo, EH; Matsumoto, K; Newcomb, R; Pierce, AR | 1 |
| Chang, CJ; Lam, TT; McCole, SM; Perlman, JI; Pulluru, P; Tso, MO | 1 |
| During, MJ; Gluckman, PD; Gunn, AJ; Gunning, MI; Mallard, CE; Tan, WK; Williams, CE | 1 |
| Henrich-Noack, P; Krieglstein, J; Rami, A; Schilling, M; Semkova, I | 1 |
| Bates, TE; Clark, JB; Keelan, J | 1 |
| Larsen, AK; Osborne, NN | 1 |
| Boiadzhian, VG; Danielian, RK; Karagezian, KG; Manucharian, GG; Ordukhanian, AA; Sekoian, AE; Sekoian, ES | 1 |
| Carvalho, AL; Cazevieille, C; DeSantis, L; Larsen, AK; Osborne, NN | 1 |
| Carlen, PL; Frantseva, MV; Perez Velazquez, JL | 1 |
| Hayashida, Y; Itano, T; Miyamoto, O; Nagao, S; Nakamura, T; Negi, T; Okada, Y; Yamagami, S | 1 |
| Ishikawa, T; Marsala, M | 1 |
| Asai, S; Ishikawa, K; Zhao, H | 1 |
| Eppinger, M; Lemmon, G; Miller, S; Nolan, D; Peoples, J; Prem, JT | 1 |
| Harris, NG; Houseman, J; Obrenovitch, TP; Symms, MR; Williams, SR; Zilkha, E | 1 |
| Jackson, P; Lu, M; Slusher, B; Tsukamoto, T; Vornov, JJ; Wang, E; Wozniak, K | 1 |
| Fujibayashi, Y; Murata, T; Omata, N; Sadato, N; Wada, Y; Waki, A; Yonekura, Y; Yoshimoto, M | 1 |
| Gerlach, M; Heim, C; Kurz, T; Lan, J; Riederer, P; Sieklucka, M; Sontag, KH; Zhang, J | 1 |
| Diaz, FG; Guyot, LL; O'Regan, MH; Phillis, JW; Song, D | 2 |
| Asai, S; Ishikawa, K; Kohno, T; Nagata, T; Takahashi, Y; Zhao, H | 1 |
| Armstead, WM | 1 |
| O'Regan, MH; Phillis, JW; Ren, J | 1 |
| Akaike, A; Hara, H; Honda, Y; Kashii, S; Shimazawa, M; Toriu, N; Yasuyoshi, H; Zhang, S | 1 |
| Diaz, FG; Guyot, LL; O'Regan, MH; Phillis, JW; Ren, J | 1 |
| Adám-Vizi, V | 1 |
| Kakuda, T; Kataoka, K; Nozawa, A; Unno, T; Utsunomiya, K; Yanase, H | 1 |
| Arai, N; Fujita, K; Furukawa, N; Goshima, Y; Misu, Y; Miyamae, T; Ohshima, E; Sasaki, Y; Suzuki, F | 1 |
| Dawson, LA; Djali, S; Gonzales, C; Vinegra, MA; Zaleska, MM | 1 |
| Furihata, K; Hayakawa, Y; Kim, JS; Seto, H; Shin-Ya, K | 1 |
| Yusa, T | 1 |
| Koinig, H; Rueda, C; Vornik, V; Zornow, MH | 1 |
| Gyo, K; Hakuba, N; Hyodo, J; Koga, K; Shudou, M; Taniguchi, M; Watanabe, F | 1 |
| Andersson, J; Enblad, P; Fasth, KJ; Frykholm, P; Hillered, L; Långström, B; Persson, L; Silander, HC; Valtysson, J; Watanabe, Y | 1 |
| Enblad, P; Frykholm, P; Hillered, L; Långström, B; Persson, L; Valtysson, J; Watanabe, Y | 1 |
| Badr, AE; Mychaskiw, G; Yin, W; Zhang, JH | 1 |
| Wang, Y; Xie, K; Zhang, Y | 1 |
| Li, Q; Miyashita, H; Shuaib, A; Yang, T; Yang, Y | 1 |
| Kontos, HA | 1 |
| Ikeda, K; Nara, Y; Tagami, M; Tsumagari, S; Yamagata, K; Yamori, Y | 1 |
| Goto, W; Hara, H; Honda, Y; Kido, N; Miyawaki, N; Tanihara, H; Yoneda, S | 1 |
| Lynch, MA | 1 |
| Abe, E; Nakayama, R; Terasaki, H; Ushijima, K; Yano, T | 1 |
| Bouldin, TW; Katz, LM; Rockoff, S; Wang, Y | 1 |
| Jiang, XF; Kamichi, S; Maeno, H; Nagata, I; Namura, S; Takami, S; Wada, K | 1 |
| Cheng, FC; Chung, SY; Lin, JY; Lin, MC | 1 |
| Calinon, F; Delbarre, B; Delbarre, G; Floyd, RA | 1 |
| Abiko, H; Chang, LH; Faden, AI; James, TL; Shimizu, H; Swanson, RA; Weinstein, PR | 1 |
| Hedges, B; Lyden, PD | 1 |
| Kataoka, K; Mitani, A | 1 |
9 review(s) available for glutamic acid and Injury, Ischemia-Reperfusion
| Article | Year |
|---|---|
Anti-cerebral ischemia reperfusion injury of polysaccharides: A review of the mechanisms.
Topics: Angiogenesis Inducing Agents; Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Brain; Brain Ischemia; Glutamic Acid; Humans; Inflammation Mediators; Neovascularization, Physiologic; Neurons; Neuroprotective Agents; Oxidative Stress; Polysaccharides; Reperfusion Injury | 2021 |
Cerebral Ischemic Postconditioning Plays a Neuroprotective Role through Regulation of Central and Peripheral Glutamate.
Topics: Brain Ischemia; Glutamic Acid; Humans; Ischemic Postconditioning; Neuroprotection; Reperfusion Injury | 2018 |
Impact of curcumin on sirtuins: A review.
Topics: AMP-Activated Protein Kinase Kinases; Amyloid beta-Peptides; Antioxidants; Apoptosis; Curcumin; Gene Expression Regulation; Glutamic Acid; Humans; Neurons; Protein Kinases; Reperfusion Injury; Sirtuin 1; Tumor Suppressor Protein p53 | 2018 |
Critical Evaluation of the Changes in Glutamine Synthetase Activity in Models of Cerebral Stroke.
Topics: Animals; Astrocytes; Disease Models, Animal; Glutamate-Ammonia Ligase; Glutamic Acid; Glutamine; Humans; Reperfusion Injury; Stroke | 2015 |
Identification of novel pharmacological targets to minimize excitotoxic retinal damage.
Topics: Animals; Cell Death; Drug Delivery Systems; Glaucoma; Glutamic Acid; Nerve Growth Factors; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Reperfusion Injury; Retinal Ganglion Cells | 2009 |
Understanding secondary injury.
Topics: Apoptosis; Brain Injuries; Calcium Channels; Cell Death; Edema; Glutamic Acid; Hemorrhage; Humans; Ischemia; Lipid Peroxidation; Neurons; Reperfusion Injury; Sodium Channels; Spinal Cord Injuries; Stroke; Trauma, Nervous System; Wounds and Injuries; Zinc | 2012 |
[Brain repair after ischemic stroke: role of neurotransmitters in post-ischemic neurogenesis].
Topics: Adult Stem Cells; Animals; Brain; Brain Damage, Chronic; Brain Ischemia; Cell Hypoxia; Cell Movement; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Humans; Intercellular Signaling Peptides and Proteins; Intracellular Signaling Peptides and Proteins; Models, Neurological; Nerve Tissue Proteins; Neural Stem Cells; Neurogenesis; Neurotransmitter Agents; Receptors, Growth Factor; Receptors, Neurotransmitter; Regeneration; Reperfusion Injury; Transcription Factors | 2012 |
[Neuroprotective effect of sodium channel blockers in ischemia: the pathomechanism of early ischemic dysfunction].
Topics: Acidosis; Anesthetics, Local; Animals; Anticonvulsants; Calcium; Calcium Channel Blockers; Cell Hypoxia; Edema; Glutamic Acid; Humans; Neuroprotective Agents; Oxidative Stress; Reactive Oxygen Species; Reperfusion Injury; Sodium; Sodium Channel Blockers; Sodium Channels; Sodium-Calcium Exchanger; Sodium-Potassium-Exchanging ATPase; Vinca Alkaloids | 2000 |
Lipoic acid confers protection against oxidative injury in non-neuronal and neuronal tissue.
Topics: Aging; Animals; Antioxidants; Glutamic Acid; Humans; Long-Term Potentiation; Mitochondria; Nervous System Diseases; Neurodegenerative Diseases; Neurons; Oxidative Stress; Reperfusion Injury; Signal Transduction; Thioctic Acid | 2001 |
177 other study(ies) available for glutamic acid and Injury, Ischemia-Reperfusion
| Article | Year |
|---|---|
Arbutin protects brain against middle cerebral artery occlusion-reperfusion (MCAo/R) injury.
Topics: Animals; Arbutin; Blood-Brain Barrier; Brain; Chromatography, High Pressure Liquid; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Infarction, Middle Cerebral Artery; Male; Maze Learning; Memory, Short-Term; Mice; Neuroprotective Agents; Neurotransmitter Agents; Permeability; Reperfusion Injury | 2021 |
Calcitriol Pretreatment Attenuates Glutamate Neurotoxicity by Regulating NMDAR and CYP46A1 Gene Expression in Rats Subjected to Transient Middle Cerebral Artery Occlusion.
Topics: Animals; Brain Ischemia; Calcitriol; Cholesterol 24-Hydroxylase; Disease Models, Animal; Gene Expression; Glutamic Acid; Infarction, Middle Cerebral Artery; Ischemia; Male; Neuroprotective Agents; Neurotoxicity Syndromes; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Reperfusion Injury; Stroke | 2022 |
SAM, a cystathionine beta-synthase activator, promotes hydrogen sulfide to promote neural repair resulting from massive cerebral infarction induced by middle cerebral artery occlusion.
Topics: Animals; Apoptosis; Brain Ischemia; Cystathionine beta-Synthase; Glucose; Glutamic Acid; Humans; Hydrogen Sulfide; Infarction, Middle Cerebral Artery; Oxygen; PC12 Cells; Rats; Reperfusion Injury | 2022 |
Insights into the role of pERK1/2 signaling in post-cerebral ischemia reperfusion sexual dysfunction in rats.
Topics: Animals; Brain Ischemia; Brain-Derived Neurotrophic Factor; Cerebral Infarction; gamma-Aminobutyric Acid; Glutamic Acid; Luteinizing Hormone; Male; MAP Kinase Signaling System; Rats; Rats, Wistar; Reperfusion; Reperfusion Injury; Testosterone | 2022 |
Cerebrolysin reduces excitotoxicity by modulation of cell-death proteins in delayed hours of ischemic reperfusion injury.
Topics: Animals; Cell Death; Glutamic Acid; Male; Neuroprotective Agents; Rats; Rats, Wistar; Reperfusion Injury | 2023 |
Addressing the alterations in cerebral ischemia-reperfusion injury on the brain mitochondrial activity: A possible link to cognitive decline.
Topics: Animals; Behavior, Animal; Brain; Brain Ischemia; Cognitive Dysfunction; Electron Transport; Glutamic Acid; Male; Mitochondria; Oxidative Stress; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Rats, Wistar; Reperfusion Injury | 2019 |
Targeting PFKFB3 alleviates cerebral ischemia-reperfusion injury in mice.
Topics: A549 Cells; Animals; Brain Ischemia; Cerebral Cortex; Disease Models, Animal; Enzyme Inhibitors; Fructosediphosphates; Gene Expression Regulation; Glutamic Acid; Glycolysis; Humans; Male; Mice; Neurons; Neuroprotective Agents; Pentose Phosphate Pathway; Phosphofructokinase-1; Phosphofructokinase-2; Primary Cell Culture; Proteasome Endopeptidase Complex; Proteolysis; Psychomotor Performance; Pyridines; Pyrrolidines; Reperfusion Injury | 2019 |
Huoxue-Tongluo-Lishui-Decoction is visual-protective against retinal ischemia-reperfusion injury.
Topics: Animals; Apoptosis; Autophagy; Biomarkers; Cytokines; Disease Models, Animal; Drugs, Chinese Herbal; Evoked Potentials, Visual; Gene Expression; Glutamic Acid; Neuroprotective Agents; NF-kappa B; Proto-Oncogene Proteins c-akt; Rats; Reperfusion Injury; Retinal Diseases; Signal Transduction; Tomography, Optical Coherence | 2020 |
Downregulation of Microrna-421 Relieves Cerebral Ischemia/Reperfusion Injuries: Involvement of Anti-apoptotic and Antioxidant Activities.
Topics: Animals; Antagomirs; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; Brain Ischemia; Cerebral Infarction; Down-Regulation; Drug Evaluation, Preclinical; Glutamic Acid; Infarction, Middle Cerebral Artery; Lipid Peroxidation; Male; Malondialdehyde; Myeloid Cell Leukemia Sequence 1 Protein; Neuroprotective Agents; Oxidative Stress; PC12 Cells; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2020 |
Protective effects of remote ischemic preconditioning against spinal cord ischemia-reperfusion injury in rats.
Topics: Animals; Anterior Horn Cells; Dizocilpine Maleate; Glutamic Acid; Ischemic Preconditioning; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reperfusion Injury; Spinal Cord; Spinal Cord Ischemia; Treatment Outcome | 2022 |
Dapsone prolong delayed excitotoxic neuronal cell death by interacting with proapoptotic/survival signaling proteins.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Brain; Cells, Cultured; Dapsone; Disease Models, Animal; Glutamic Acid; Infarction, Middle Cerebral Artery; Male; Neurons; Neuroprotective Agents; Rats, Wistar; Reperfusion Injury; Signal Transduction | 2020 |
Rg1 in combination with mannitol protects neurons against glutamate-induced ER stress via the PERK-eIF2 α-ATF4 signaling pathway.
Topics: Activating Transcription Factor 4; Animals; Apoptosis; Central Nervous System Agents; Diuretics, Osmotic; Drug Therapy, Combination; eIF-2 Kinase; Endoplasmic Reticulum Stress; Eukaryotic Initiation Factor-2; Ginsenosides; Glutamic Acid; Male; Mannitol; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2020 |
Role of HMGB1/TLR4 Axis in Ischemia/Reperfusion-Impaired Extracellular Glutamate Clearance in Primary Astrocytes.
Topics: Animals; Astrocytes; Brain Ischemia; Cells, Cultured; Culture Media, Conditioned; Excitatory Amino Acid Transporter 1; Glutamic Acid; HMGB1 Protein; Neurons; Oxygen; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Toll-Like Receptor 4 | 2020 |
Mild hypothermia protects rat cortical neurons against oxygen-glucose deprivation/reoxygenation injury via the PI3K/Akt pathway.
Topics: Animals; Cell Survival; Cerebral Cortex; Chromones; Excitatory Amino Acid Transporter 2; Glutamic Acid; Hypothermia, Induced; In Vitro Techniques; Ischemic Stroke; Kainic Acid; Morpholines; Neurons; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats; Reperfusion Injury | 2021 |
Neuroprotective effects of Senkyunolide I against glutamate-induced cells death by attenuating JNK/caspase-3 activation and apoptosis.
Topics: Animals; Apoptosis; Benzofurans; Brain Ischemia; Caspase 3; Cell Death; Cell Survival; Cells, Cultured; Glutamic Acid; MAP Kinase Signaling System; Mice; Neuroblastoma; Neuroprotection; Neuroprotective Agents; Reperfusion Injury; Signal Transduction | 2021 |
Capsaicin protects cortical neurons against ischemia/reperfusion injury via down-regulating NMDA receptors.
Topics: Animals; Behavior, Animal; Capsaicin; Cells, Cultured; Down-Regulation; Excitatory Amino Acids; Glutamic Acid; Infarction, Middle Cerebral Artery; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reperfusion Injury; TRPV Cation Channels | 2017 |
A non-ionotropic activity of NMDA receptors contributes to glycine-induced neuroprotection in cerebral ischemia-reperfusion injury.
Topics: Animals; Brain Ischemia; Disease Models, Animal; Glutamic Acid; Glycine; Male; Neuroprotection; Protein Binding; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats; Receptors, N-Methyl-D-Aspartate; Reperfusion Injury; Severity of Illness Index | 2017 |
The administration of hydrogen sulphide prior to ischemic reperfusion has neuroprotective effects in an acute stroke model.
Topics: Animals; Apoptosis; Aspartic Acid; Brain Ischemia; Disease Models, Animal; Glutamic Acid; Humans; Hydrogen Sulfide; Neuroprotective Agents; Rats; Reperfusion Injury; Stroke; Taurine | 2017 |
[Protective effects of Ginkgo Terpene Lactones Meglumine Injection on focal cerebral ischemia in rats].
Topics: Animals; Aspartic Acid; Brain Ischemia; Calcium; Creatine Kinase, BB Form; Ginkgo biloba; Glutamic Acid; Glutathione; L-Lactate Dehydrogenase; Lactic Acid; Lactones; Male; Malondialdehyde; Meglumine; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Superoxide Dismutase; Terpenes | 2017 |
[Ghrelin protects against hippocampal injury after global cerebral ischemia/reperfusion and regulate glutamic acid/γ-aminobutyric acid sensitive neuron discharge]
Topics: Animals; Brain; Brain Ischemia; Cerebral Infarction; gamma-Aminobutyric Acid; Ghrelin; Glutamic Acid; Glutathione; Hippocampus; Male; Neurons; Protective Agents; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2016 |
The dual role of KCNQ/M channels upon OGD or OGD/R insults in cultured cortical neurons of mice: Timing is crucial in targeting M-channels against ischemic injur ies.
Topics: Animals; Carbamates; Female; Glucose; Glutamic Acid; KCNQ Potassium Channels; Male; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C57BL; Neurons; Oxygen; Phenylenediamines; Reperfusion Injury | 2019 |
Neuroprotection mediated by remote preconditioning is associated with a decrease in systemic oxidative stress and changes in brain and blood glutamate concentration.
Topics: Animals; Brain; Glutamic Acid; Ischemia; Ischemic Preconditioning; Male; Neuroprotection; Oxidative Stress; Rats, Wistar; Reperfusion Injury; Superoxide Dismutase | 2019 |
Gua Lou Gui Zhi decoction exerts neuroprotective effects on post-stroke spasticity via the modulation of glutamate levels and AMPA receptor expression.
Topics: Animals; Behavior, Animal; Brain Chemistry; Cerebral Infarction; Drugs, Chinese Herbal; Glutamic Acid; Male; Muscle Spasticity; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Reperfusion Injury | 2013 |
Effect of modulating the allosteric sites of N-methyl-D-aspartate receptors in ischemia-reperfusion induced acute kidney injury.
Topics: Acute Kidney Injury; Allosteric Site; Animals; Catalase; Glutamic Acid; Glutathione; Ketamine; Kynurenic Acid; Magnesium Sulfate; Male; Models, Animal; Oxidative Stress; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Reperfusion Injury; Spermidine; Superoxides; Thiobarbituric Acid Reactive Substances | 2013 |
The neuroprotective mechanism of puerarin treatment of acute spinal cord injury in rats.
Topics: Acute Disease; Animals; Apoptosis; Glutamic Acid; Isoflavones; Male; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Reperfusion Injury; RNA, Messenger; Spinal Cord; Spinal Cord Injuries | 2013 |
Global and ocular hypothermic preconditioning protect the rat retina from ischemic damage.
Topics: Animals; Biological Transport; Cell Count; Cold Temperature; Electroretinography; Glutamate-Ammonia Ligase; Glutamic Acid; Hypothermia, Induced; Intravitreal Injections; Male; Rats; Rats, Wistar; Recovery of Function; Reperfusion Injury; Retinal Diseases; Retinal Ganglion Cells | 2013 |
Glutamate oxidase biosensor based on mixed ceria and titania nanoparticles for the detection of glutamate in hypoxic environments.
Topics: Amino Acid Oxidoreductases; Animals; Biosensing Techniques; Cell Hypoxia; Cerebral Cortex; Chitosan; Glutamic Acid; Male; Nanoparticles; Oxygen; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Titanium | 2014 |
Activation of muscarinic receptors protects against retinal neurons damage and optic nerve degeneration in vitro and in vivo models.
Topics: Animals; Animals, Newborn; Caspase 3; Cells, Cultured; Choline O-Acetyltransferase; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glutamic Acid; Male; Muscarinic Agonists; Nerve Degeneration; Neurons; Optic Nerve; Pilocarpine; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Reperfusion Injury; Retina | 2014 |
Effects of catalpol on ATPase and amino acids in gerbils with cerebral ischemia/reperfusion injury.
Topics: Adenosine Triphosphatases; Animals; Aspartic Acid; Brain Chemistry; Brain Ischemia; Carotid Artery, Common; Cell Membrane; Constriction; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Gerbillinae; Glutamic Acid; Iridoid Glucosides; Male; Models, Animal; Molecular Structure; Nerve Tissue Proteins; Neuroprotective Agents; Premedication; Reperfusion Injury; Single-Blind Method | 2014 |
[The protective effect of mild hypothermia pretreatment against injury to primary cultured cortical neurons induced of rat by glutamate].
Topics: Animals; Apoptosis; Cell Survival; Cells, Cultured; Cerebral Cortex; Glutamic Acid; Hypothermia, Induced; Ischemic Preconditioning; Male; Neurons; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2014 |
Effect of Gua Lou Gui Zhi decoction on focal cerebral ischemia-reperfusion injury through regulating the expression of excitatory amino acids and their receptors.
Topics: Animals; Aspartic Acid; Chromatography, High Pressure Liquid; Disease Models, Animal; Drugs, Chinese Herbal; Excitatory Amino Acids; Glutamic Acid; Glycine; Immunohistochemistry; Male; Motor Activity; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Reperfusion Injury | 2014 |
[Effect of a new derivative of glutamic and apovincaminic acids on brain metabolism in post-ischemic period].
Topics: Acidosis, Lactic; Animals; Blood Glucose; Brain; Brain Ischemia; Cats; Glutamic Acid; Glycine; Lactic Acid; Neuroprotective Agents; Oxygen Consumption; Reperfusion Injury; Vinca Alkaloids | 2014 |
Hippocampus and cerebral cortex present a different autophagic response after oxygen and glucose deprivation in an ex vivo rat brain slice model.
Topics: Animals; Autophagy; Brain Ischemia; Cell Hypoxia; Cerebral Cortex; Glucose; Glutamic Acid; Hippocampus; In Vitro Techniques; Male; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Stroke | 2015 |
Effect of ligustrazine on levels of amino acid neurotransmitters in rat striatum after cerebral ischemia-reperfusion injury.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Brain Ischemia; Corpus Striatum; gamma-Aminobutyric Acid; Glutamic Acid; Infarction, Middle Cerebral Artery; Male; Microdialysis; Molecular Structure; Neurotransmitter Agents; Pyrazines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Taurine; Time Factors | 2014 |
Ultrasound-enhanced protective effect of tetramethylpyrazine against cerebral ischemia/reperfusion injury.
Topics: Animals; bcl-2-Associated X Protein; Brain Ischemia; Glutamic Acid; High-Energy Shock Waves; Interleukin-8; Ligusticum; Medicine, Chinese Traditional; Microscopy, Electron, Scanning; PC12 Cells; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Superoxide Dismutase; Tumor Necrosis Factor-alpha; Vasodilator Agents | 2014 |
c-Src function is necessary and sufficient for triggering microglial cell activation.
Topics: Animals; Apoptosis; Cell Line; Cells, Cultured; Chickens; CSK Tyrosine-Protein Kinase; Gliosis; Glutamic Acid; HEK293 Cells; Humans; Inflammation; Ischemia; Lipopolysaccharides; Male; Mice; Microglia; Neurons; Phagocytosis; Proto-Oncogene Proteins pp60(c-src); Rats, Wistar; Reperfusion Injury; Retinal Neurons; src-Family Kinases; Tumor Necrosis Factor-alpha | 2015 |
Pinocembrin attenuates hippocampal inflammation, oxidative perturbations and apoptosis in a rat model of global cerebral ischemia reperfusion.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Apoptosis; Biomarkers; Brain Ischemia; Carotid Stenosis; Cerebral Infarction; Flavanones; Glutamic Acid; Glutathione; Hippocampus; L-Lactate Dehydrogenase; Male; Oxidative Stress; Rats; Rats, Wistar; Reperfusion Injury | 2015 |
Interaction between NMDA glutamatergic and nitrergic enteric pathways during in vitro ischemia and reperfusion.
Topics: Animals; Enzyme Inhibitors; Glutamic Acid; Guinea Pigs; Ileum; Male; Myenteric Plexus; N-Methylaspartate; Neurons; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitrites; Receptors, N-Methyl-D-Aspartate; Reperfusion Injury; RNA, Messenger | 2015 |
Ischemic preconditioning and postconditioning alleviates hippocampal tissue damage through abrogation of apoptosis modulated by oxidative stress and inflammation during transient global cerebral ischemia-reperfusion in rats.
Topics: Animals; Apoptosis; Biomarkers; Brain Ischemia; Encephalitis; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Ischemic Postconditioning; Ischemic Preconditioning; L-Lactate Dehydrogenase; Male; Oxidative Stress; Rats, Wistar; Reperfusion Injury | 2015 |
In vitro and in vivo efficacy of a potent opioid receptor agonist, biphalin, compared to subtype-selective opioid receptor agonists for stroke treatment.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Brain Edema; Brain Infarction; Brain Ischemia; Cells, Cultured; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glutamic Acid; Ischemia; Motor Activity; Neurons; Neuroprotective Agents; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reperfusion Injury; Severity of Illness Index; Stroke | 2015 |
Neuroprotective effects of pioglitazone against transient cerebral ischemic reperfusion injury in diabetic rats: Modulation of antioxidant, anti-inflammatory, and anti-apoptotic biomarkers.
Topics: Animals; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; Brain Ischemia; Carotid Artery, Common; Cytokines; Diabetes Mellitus, Experimental; Glutamic Acid; Hippocampus; Male; Neuroprotective Agents; NF-kappa B; Oxidative Stress; Pioglitazone; Rats; Rats, Wistar; Reperfusion Injury; Signal Transduction; Thiazolidinediones | 2015 |
Effects of simvastatin on malondialdehyde level and esterase activity in plasma and tissue of normolipidemic rats.
Topics: Animals; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; Brain Ischemia; Carotid Artery, Common; Cytokines; Diabetes Mellitus, Experimental; Glutamic Acid; Hippocampus; Male; Neuroprotective Agents; NF-kappa B; Oxidative Stress; Pioglitazone; Rats; Rats, Wistar; Reperfusion Injury; Signal Transduction; Simvastatin; Thiazolidinediones | 2015 |
Beneficial effect of magnesium lithospermate B on cerebral ischemia-reperfusion injury in rats involves the regulation of miR-107/glutamate transporter 1 pathway.
Topics: Animals; Apoptosis; Brain; Cell Line; Drugs, Chinese Herbal; Excitatory Amino Acid Transporter 2; Glutamic Acid; Hypoxia; Infarction, Middle Cerebral Artery; Male; MicroRNAs; Neurons; Neuroprotective Agents; Rats, Sprague-Dawley; Reperfusion Injury | 2015 |
An Antagomir to MicroRNA-106b-5p Ameliorates Cerebral Ischemia and Reperfusion Injury in Rats Via Inhibiting Apoptosis and Oxidative Stress.
Topics: Animals; Antagomirs; Antioxidants; Apoptosis; Base Sequence; bcl-2-Associated X Protein; Brain Ischemia; Cerebral Cortex; Down-Regulation; Gene Expression Regulation; Glutamic Acid; Infarction, Middle Cerebral Artery; Male; Malondialdehyde; MicroRNAs; Myeloid Cell Leukemia Sequence 1 Protein; Oxidative Stress; PC12 Cells; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Superoxide Dismutase; Up-Regulation | 2017 |
Low dose of L-glutamic acid attenuated the neurological dysfunctions and excitotoxicity in bilateral common carotid artery occluded mice.
Topics: Animals; Brain; Brain Ischemia; Carotid Artery, Common; Disease Models, Animal; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Glutamic Acid; Glutathione; Male; Memantine; Mice; Neuroprotective Agents; Nitric Oxide; Receptors, N-Methyl-D-Aspartate; Reperfusion Injury; Time Factors | 2016 |
Castanea sativa Mill. Bark Extract Protects U-373 MG Cells and Rat Brain Slices Against Ischemia and Reperfusion Injury.
Topics: Animals; Apoptosis; Astrocytes; Brain Ischemia; Cell Line, Tumor; Cell Survival; Cerebral Cortex; Fagaceae; Glutamic Acid; Humans; Hydrogen Peroxide; In Vitro Techniques; Male; Neuroprotective Agents; Phytotherapy; Plant Bark; Plant Extracts; Rats; Rats, Wistar; Reactive Oxygen Species; Reperfusion Injury | 2017 |
GluR6-containing KA receptor mediates the activation of p38 MAP kinase in rat hippocampal CA1 region during brain ischemia injury.
Topics: Animals; Brain Infarction; Cell Survival; Disease Models, Animal; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; GluK2 Kainate Receptor; Glutamic Acid; Hippocampus; Hypoxia-Ischemia, Brain; Intracellular Signaling Peptides and Proteins; Male; MAP Kinase Kinase 3; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinase Kinase 11; Oligodeoxyribonucleotides, Antisense; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; Reperfusion Injury; Synaptic Transmission | 2009 |
Both amacrine and bipolar cells release glutamate in the rat retina after ischemia/reperfusion insult in vitro.
Topics: Amacrine Cells; Animals; Apoptosis; Calbindins; Female; gamma-Aminobutyric Acid; Glucose; Glutamic Acid; Immunoenzyme Techniques; Oxygen; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Retina; Retinal Bipolar Cells; S100 Calcium Binding Protein G | 2008 |
Ginkgo biloba extract neuroprotective action is dependent on heme oxygenase 1 in ischemic reperfusion brain injury.
Topics: Animals; Antioxidants; Brain Damage, Chronic; Brain Ischemia; Cells, Cultured; Cerebrovascular Circulation; Cyclopentanes; Drug Evaluation, Preclinical; Enzyme Induction; Excitatory Amino Acid Antagonists; Furans; Ginkgo biloba; Ginkgolides; Glutamic Acid; Heme Oxygenase-1; Infarction, Middle Cerebral Artery; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Plant Extracts; Reperfusion Injury; Response Elements | 2008 |
Superior cardiac function via anaplerotic pyruvate in the immature swine heart after cardiopulmonary bypass and reperfusion.
Topics: Animals; Animals, Newborn; Carbon Isotopes; Cardiopulmonary Bypass; Chromatography, Liquid; Citric Acid Cycle; Glutamic Acid; Hemodynamics; Infusions, Parenteral; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Myocardial Contraction; Myocardial Reperfusion; Myocardium; Pyruvate Carboxylase; Pyruvic Acid; Reperfusion Injury; Swine | 2008 |
Rational basis for the development of coenzyme Q10 as a neurotherapeutic agent for retinal protection.
Topics: Animals; Calpain; Cell Death; Glaucoma; Glutamic Acid; Humans; Intraocular Pressure; Neuroprotective Agents; Oxidative Stress; Rats; Reperfusion Injury; Retina; Retinal Ganglion Cells; Ubiquinone | 2008 |
Contralateral leg as a control during skeletal muscle ischemia-reperfusion.
Topics: Animals; Ascorbic Acid; Cell Respiration; Electron Transport Chain Complex Proteins; Glutamic Acid; Ischemia; Lower Extremity; Malates; Male; Mitochondria, Muscle; Mitochondrial Diseases; Muscle, Skeletal; Rats; Rats, Wistar; Reperfusion Injury; Succinic Acid; Tetramethylphenylenediamine | 2009 |
Transient forebrain ischemia impact on lymphocyte DNA damage, glutamic acid level, and SOD activity in blood.
Topics: Animals; DNA Damage; Glutamic Acid; Ischemic Attack, Transient; Lymphocytes; Male; Prosencephalon; Rats; Rats, Wistar; Reperfusion Injury; Superoxide Dismutase | 2009 |
Preservation of glutamate immunoreactivity and ischemic change in photoreceptor inner segments in the retina after different protocols of perfusion fixation.
Topics: Animals; Cats; Glutamic Acid; Immunoenzyme Techniques; Ischemia; Reperfusion Injury; Retinal Photoreceptor Cell Inner Segment; Retinal Vessels; Tissue Fixation | 2009 |
Elevation of jugular venous superoxide anion radical is associated with early inflammation, oxidative stress, and endothelial injury in forebrain ischemia-reperfusion rats.
Topics: Animals; Brain Ischemia; Electricity; Electronics, Medical; Encephalitis; Endothelium, Vascular; Glutamic Acid; HMGB1 Protein; Intercellular Adhesion Molecule-1; Jugular Veins; Male; Malondialdehyde; Monitoring, Physiologic; Oxidative Stress; Prosencephalon; Rats; Rats, Wistar; Reperfusion Injury; Superoxides; Time Factors | 2009 |
Neuroprotective effects of a standardized flavonoid extract from Diospyros kaki leaves.
Topics: Animals; Apoptosis; CA1 Region, Hippocampal; Cell Culture Techniques; Cell Death; Cerebral Cortex; Disease Models, Animal; Flavonoids; Glutamic Acid; Ischemic Attack, Transient; Male; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2009 |
Involvement of glutamate in retinal protection against ischemia/reperfusion damage induced by post-conditioning.
Topics: Animals; Electroretinography; Glial Fibrillary Acidic Protein; Glutamate-Ammonia Ligase; Glutamic Acid; Glutaminase; Glutamine; Intraocular Pressure; Ischemic Preconditioning; Male; Neuroprotective Agents; Rats; Rats, Wistar; Reperfusion Injury; Retina; Tritium | 2009 |
Protection by taurine of rat brain cortical slices against oxygen glucose deprivation- and reoxygenation-induced damage.
Topics: Animals; Biomimetics; Brain; Chloride Channels; Edema; Glucose; Glutamic Acid; In Vitro Techniques; L-Lactate Dehydrogenase; Neurons; Oxygen; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Reperfusion Injury; Taurine; Water | 2009 |
Glutamate excitotoxicity mediates neuronal apoptosis after hypothermic circulatory arrest.
Topics: Animals; Apoptosis; Brain; Circulatory Arrest, Deep Hypothermia Induced; Citrulline; Dizocilpine Maleate; DNA Fragmentation; Dogs; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Glutamic Acid; Glycine; In Situ Nick-End Labeling; Microdialysis; Microscopy, Electron; Necrosis; Neurons; Nitric Oxide; Reperfusion Injury | 2010 |
Microsomal prostaglandin E synthase-1 and cyclooxygenase-2 are both required for ischaemic excitotoxicity.
Topics: Animals; Brain Ischemia; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Disease Models, Animal; Female; Glutamic Acid; Hippocampus; Intramolecular Oxidoreductases; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microsomes; Neurons; Prostaglandin-E Synthases; Rats; Reperfusion Injury; Stroke | 2010 |
Real-time ischemic condition monitoring in normoglycemic and hyperglycemic rats.
Topics: Animals; Brain; Brain Ischemia; Cerebrovascular Circulation; Electroencephalography; Extracellular Space; Glutamic Acid; Hyperglycemia; Male; Monitoring, Physiologic; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Streptozocin; Time Factors | 2010 |
Contributions of poly(ADP-ribose) polymerase-1 and -2 to nuclear translocation of apoptosis-inducing factor and injury from focal cerebral ischemia.
Topics: Active Transport, Cell Nucleus; Animals; Apoptosis Inducing Factor; Brain; Brain Ischemia; Cell Nucleus; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glutamic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Degeneration; Neurons; Oxidative Stress; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Reperfusion Injury | 2010 |
Transient focal cerebral ischemia significantly alters not only EAATs but also VGLUTs expression in rats: relevance of changes in reactive astroglia.
Topics: Animals; Astrocytes; Blotting, Western; Caudate Nucleus; Cell Death; Cell Movement; Cerebral Cortex; Fluorescent Antibody Technique; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Immunohistochemistry; Infarction, Middle Cerebral Artery; Ischemic Attack, Transient; Microscopy, Confocal; Neuroglia; Neuronal Plasticity; Putamen; Rats; Reperfusion Injury; Vesicular Glutamate Transport Proteins | 2010 |
Pharmacological evaluation of glutamate transporter 1 (GLT-1) mediated neuroprotection following cerebral ischemia/reperfusion injury.
Topics: Animals; Brain; Brain Ischemia; Ceftriaxone; Cerebral Infarction; Disease Models, Animal; Excitatory Amino Acid Transporter 2; Glutamate-Ammonia Ligase; Glutamic Acid; Kainic Acid; Male; Neuroglia; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Up-Regulation | 2010 |
The calcineurin inhibitor, FK506, does not alter glutamate transport in the ischaemic mouse retina.
Topics: Amino Acid Transport System X-AG; Animals; Biological Transport; Calcineurin Inhibitors; Female; Glutamic Acid; Immunohistochemistry; Immunosuppressive Agents; Mice; Mice, Inbred C57BL; Reperfusion Injury; Retinal Diseases; Tacrolimus; Tetradecanoylphorbol Acetate | 2010 |
Treadmill pre-training suppresses the release of glutamate resulting from cerebral ischemia in rats.
Topics: Animals; Corpus Striatum; Exercise Test; Extracellular Space; Glutamic Acid; Infarction, Middle Cerebral Artery; Male; Models, Animal; Physical Conditioning, Animal; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Reperfusion Injury | 2010 |
Effects of one-day reperfusion after transient forebrain ischemia on circulatory system in the rat.
Topics: Animals; Brain Ischemia; Cerebrovascular Circulation; DNA Damage; Glutamic Acid; Lymphocytes; Male; Prosencephalon; Rats; Rats, Wistar; Reperfusion Injury; Superoxide Dismutase | 2010 |
Neuroprotective effects of magnesium-sulfate on ischemic injury mediated by modulating the release of glutamate and reduced of hyperreperfusion.
Topics: Animals; Antigens, Nuclear; Apoptosis; Brain Ischemia; CA1 Region, Hippocampal; Caspase 3; Cerebrovascular Circulation; Drug Evaluation, Preclinical; Glutamic Acid; Laser-Doppler Flowmetry; Magnesium Sulfate; Male; Nerve Tissue Proteins; Neuroprotective Agents; Neurotoxins; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Single-Blind Method | 2011 |
[Effect of propofol on glutamate, ascorbic acid release in hippocampus during global cerebral ischemia/reperfusion in rats].
Topics: Animals; Ascorbic Acid; Brain Ischemia; Glutamic Acid; Hippocampus; Male; Propofol; Rats; Rats, Wistar; Reperfusion Injury | 2006 |
Effect of ginkgolide B on striatal extracellular amino acids in middle cerebral artery occluded rats.
Topics: Amino Acids; Animals; Aspartic Acid; Brain Ischemia; Corpus Striatum; gamma-Aminobutyric Acid; Ginkgo biloba; Ginkgolides; Glutamic Acid; Glycine; Infarction, Middle Cerebral Artery; Lactones; Male; Phytotherapy; Plant Extracts; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2011 |
Neuroprotection by NMDA preconditioning against glutamate cytotoxicity is mediated through activation of ERK 1/2, inactivation of JNK, and by prevention of glutamate-induced CREB inactivation.
Topics: Animals; Brain Ischemia; Cell Survival; Cyclic AMP Response Element-Binding Protein; Enzyme Activation; Excitatory Amino Acid Agonists; Glutamic Acid; Ischemic Preconditioning; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; N-Methylaspartate; Neurons; Neuroprotective Agents; Neurotoxins; Primary Cell Culture; Rats; Reperfusion Injury | 2012 |
Neuroprotection of the leaf and stem of Vitis amurensis and their active compounds against ischemic brain damage in rats and excitotoxicity in cultured neurons.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Brain Edema; Brain Injuries; Brain Ischemia; Cyclooxygenase 2; Female; Glutamic Acid; Glutathione; Lipid Peroxidation; Male; Methanol; Molecular Structure; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; Phytotherapy; Plant Extracts; Plant Leaves; Plant Stems; Pregnancy; Primary Cell Culture; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Reperfusion Injury; Vitis | 2012 |
[Penehyclidine hydrochloride inhibits glutamate release and related research in global brain ischemia/reperfusion rats].
Topics: Animals; Brain Ischemia; CA1 Region, Hippocampal; Cholinergic Antagonists; Glutamic Acid; Male; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reperfusion Injury | 2011 |
Molecular alterations associated with the NMDA preconditioning-induced neuroprotective mechanism against glutamate cytotoxicity.
Topics: Animals; Brain Ischemia; Female; Glutamic Acid; Ischemic Preconditioning; Neurons; Neuroprotective Agents; Primary Cell Culture; Rats; Receptors, N-Methyl-D-Aspartate; Reperfusion Injury | 2012 |
Neuroprotective effect of Buyang Huanwu decoction against focal cerebral ischemia/reperfusion injury in rats--time window and mechanism.
Topics: Animals; Cerebral Infarction; Cerebrovascular Disorders; Drugs, Chinese Herbal; Glutamic Acid; Ischemic Attack, Transient; Magnoliopsida; Male; Nervous System Diseases; Neuroprotective Agents; Oligochaeta; Phytotherapy; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Reperfusion Injury; RNA, Messenger; Stroke; Time Factors | 2012 |
Phenolic alkaloids from Menispermum dauricum rhizome protect against brain ischemia injury via regulation of GLT-1, EAAC1 and ROS generation.
Topics: Alkaloids; Animals; Brain Ischemia; Cell Hypoxia; Cell Survival; Cells, Cultured; Excitatory Amino Acid Transporter 2; Excitatory Amino Acid Transporter 3; Extracellular Fluid; Gene Expression; Glutamic Acid; Lactate Dehydrogenases; Male; Menispermum; Neurons; Neuroprotective Agents; Phenols; Plant Extracts; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Reperfusion Injury; Rhizome | 2012 |
Alterations of glutamate, glutamine, and related amino acids in the anterior eye secondary to ischaemia and reperfusion.
Topics: Amino Acids; Animals; Anterior Eye Segment; Aqueous Humor; Chromatography, High Pressure Liquid; Ciliary Body; Glutamate-Ammonia Ligase; Glutamic Acid; Glutamine; Homeostasis; Lens, Crystalline; Pigment Epithelium of Eye; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2012 |
Elucidation of neuroprotective role of endogenous GABA and energy metabolites middle cerebral artery occluded model in rats.
Topics: Adenosine Triphosphate; Animals; Aspartic Acid; Brain; Disease Models, Animal; Excitatory Amino Acids; gamma-Aminobutyric Acid; Glutamic Acid; Glutathione; Infarction, Middle Cerebral Artery; L-Lactate Dehydrogenase; Male; Neuroprotective Agents; Pyruvates; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Sodium-Potassium-Exchanging ATPase; Time Factors | 2012 |
Lateral hypothalamic area mediated the protective effects of microinjection of glutamate into interpositus nucleus on gastric ischemia-reperfusion injury in rats.
Topics: Animals; Apoptosis; Cell Proliferation; Cerebellum; gamma-Aminobutyric Acid; Gastric Juice; Gastric Mucosa; Glutamic Acid; Hydrogen-Ion Concentration; Hypothalamic Area, Lateral; Male; Microinjections; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Stomach | 2012 |
A novel CB2 agonist, COR167, potently protects rat brain cortical slices against OGD and reperfusion injury.
Topics: Adamantane; Animals; Cannabinoid Receptor Agonists; Cerebral Cortex; Glucose; Glutamic Acid; Interleukin-6; L-Lactate Dehydrogenase; Male; Molecular Structure; Oxygen; Quinolones; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2; Reperfusion Injury; Tissue Culture Techniques; Tumor Necrosis Factor-alpha; Water | 2012 |
Honokiol protects brain against ischemia-reperfusion injury in rats through disrupting PSD95-nNOS interaction.
Topics: Animals; Biphenyl Compounds; Bisbenzimidazole; Blotting, Western; Cell Hypoxia; Cells, Cultured; Central Nervous System Depressants; Cerebral Cortex; Coloring Agents; Cytosol; Disks Large Homolog 4 Protein; Glucose; Glutamic Acid; Immunoprecipitation; In Vitro Techniques; Infarction, Middle Cerebral Artery; Intracellular Signaling Peptides and Proteins; L-Lactate Dehydrogenase; Lignans; Male; Membrane Proteins; Nitric Oxide; Nitric Oxide Synthase Type I; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reperfusion Injury; Translocation, Genetic | 2013 |
Neuroregulative mechanism of hypothalamic paraventricular nucleus on gastric ischemia-reperfusion injury in rats.
Topics: Animals; Disease Models, Animal; Electric Stimulation; Glutamic Acid; Hypophysectomy; Male; Paraventricular Hypothalamic Nucleus; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Solitary Nucleus; Sympathetic Nervous System; Vagotomy | 2002 |
Bilobalide, a component of the Ginkgo biloba extract (EGb 761), protects against neuronal death in global brain ischemia and in glutamate-induced excitotoxicity.
Topics: Administration, Oral; Animals; Brain Ischemia; Cell Death; Cerebellum; Cyclopentanes; Diterpenes; Electron Transport Complex IV; Furans; Gerbillinae; Ginkgo biloba; Ginkgolides; Glutamic Acid; Hippocampus; Male; Neurons; Neuroprotective Agents; Plant Extracts; Reperfusion Injury | 2002 |
Glutamate release by an Na+ load and oxidative stress in nerve terminals: relevance to ischemia/reperfusion.
Topics: Adenosine Triphosphate; Animals; Brain Chemistry; Glutamic Acid; Guinea Pigs; Hydrogen Peroxide; Oxidants; Oxidative Stress; Presynaptic Terminals; Reperfusion Injury; Sodium; Synaptosomes; Veratridine | 2002 |
Protective effects of timolol against the neuronal damage induced by glutamate and ischemia in the rat retina.
Topics: Action Potentials; Acute Disease; Animals; Cell Death; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Electroretinography; Excitatory Amino Acid Antagonists; Fetus; Glaucoma; Glutamic Acid; Hypoxia-Ischemia, Brain; Neuroprotective Agents; Rats; Rats, Wistar; Reperfusion Injury; Retinal Degeneration; Retinal Ganglion Cells; Timolol | 2002 |
[Effect of tianma cuzhi keli (TMCZKL) on contents of transmitter amino acids of brain tissue in the mouse repetitious cerebral ischemia reperfusion].
Topics: Animals; Aspartic Acid; Brain Ischemia; Cerebral Cortex; Drug Combinations; Drugs, Chinese Herbal; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Male; Mice; Neuroprotective Agents; Orchidaceae; Plants, Medicinal; Random Allocation; Reperfusion Injury; Rubiaceae | 2001 |
Chronological changes of N-methyl-D-aspartate receptors and excitatory amino acid carrier 1 immunoreactivities in CA1 area and subiculum after transient forebrain ischemia.
Topics: Amino Acid Transport System X-AG; Animals; Cell Death; Dentate Gyrus; Gerbillinae; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Hippocampus; Immunohistochemistry; Ischemic Attack, Transient; Male; Neurons; Reaction Time; Receptors, N-Methyl-D-Aspartate; Reperfusion Injury; Symporters; Synapses; Synaptic Transmission; Time Factors | 2001 |
Effect of MCI-9042, a 5-HT2 receptor antagonist, on retinal ganglion cell death and retinal ischemia.
Topics: Animals; Cell Death; Cells, Cultured; Dose-Response Relationship, Drug; Electroretinography; Excitatory Amino Acid Antagonists; Glutamic Acid; Neuroprotective Agents; Ocular Hypertension; Rats; Rats, Wistar; Reperfusion Injury; Retinal Ganglion Cells; Retinal Vessels; Serotonin Antagonists; Succinates | 2003 |
Relationship between glutamate in the limbic system and hypothalamus-pituitary-adrenal axis after middle cerebral artery occlusion in rats.
Topics: Animals; Glutamic Acid; Hypothalamo-Hypophyseal System; Infarction, Middle Cerebral Artery; Limbic System; Male; Pituitary-Adrenal System; Rats; Rats, Wistar; Reperfusion Injury | 2003 |
Aspartate transporter expression and activity in hypertrophic rat heart and ischaemia-reperfusion injury.
Topics: Adenosine Triphosphate; Alanine; Amino Acid Transport System X-AG; Animals; Aspartic Acid; Blotting, Western; Cardiomegaly; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 3; Glutamate Dehydrogenase; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Glutamine; Heart; Heart Rate; Ischemia; Kinetics; L-Lactate Dehydrogenase; Lactic Acid; Male; Myocardium; Myocytes, Cardiac; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Reperfusion; Reperfusion Injury; Reverse Transcriptase Polymerase Chain Reaction; Sarcolemma; Symporters; Ventricular Pressure | 2004 |
Transglutaminase activity and transglutaminase mRNA transcripts in gerbil brain ischemia.
Topics: Animals; Brain; Brain Ischemia; Calcium Signaling; Cerebral Cortex; Disease Models, Animal; Genes, Regulator; Gerbillinae; Glutamic Acid; Hippocampus; Ischemic Attack, Transient; Male; Neurotoxins; Protein Isoforms; Reperfusion Injury; RNA, Messenger; Transglutaminases; Up-Regulation | 2004 |
5-HT control of ischemia-evoked glutamate efflux from human cerebrocortical slices.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adult; Aged; Aspartic Acid; Brain Ischemia; Cerebral Cortex; Glucose; Glutamic Acid; Humans; Hypoxia, Brain; In Vitro Techniques; Male; Middle Aged; Reperfusion Injury; Serotonin; Serotonin Receptor Agonists | 2004 |
Localization and function of the brain excitatory amino acid transporter type 1 in cardiac mitochondria.
Topics: Adenoviridae; Animals; Aspartic Acid; Blotting, Northern; Brain; Cells, Cultured; Coloring Agents; Cytochromes c; Digitonin; DNA, Complementary; Excitatory Amino Acid Transporter 1; Genetic Vectors; Glutamic Acid; Hypoxia; Immunoblotting; Immunohistochemistry; Malates; Microscopy, Fluorescence; Mitochondria; Mitochondria, Heart; Myocardium; Open Reading Frames; Rats; Rats, Inbred WKY; Rats, Sprague-Dawley; Reperfusion Injury; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Messenger; Subcellular Fractions; Tetrazolium Salts; Thiazoles; Transfection | 2004 |
Ischemia and reoxygenation induced amino acid release release and tissue damage in the slices of rat corpus striatum.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Calcium; Citrulline; Corpus Striatum; Female; gamma-Aminobutyric Acid; Glutamic Acid; Hypoxia; Ions; Ischemia; L-Lactate Dehydrogenase; Male; Oxygen; Rats; Rats, Wistar; Reperfusion Injury; Taurine; Tetrodotoxin; Time Factors | 2004 |
Glutamate efflux from human cerebrocortical slices during ischemia: vesicular-like mode of glutamate release and sensitivity to A(2A) adenosine receptor blockade.
Topics: Adenosine A2 Receptor Antagonists; Adult; Aged; Anesthetics, Local; Aspartic Acid; Brain Ischemia; Calcium; Cerebral Cortex; Female; Glucose; Glutamic Acid; Humans; In Vitro Techniques; Male; Middle Aged; Neuroprotective Agents; Pyrimidines; Reperfusion Injury; Synaptic Vesicles; Tetrodotoxin; Triazoles | 2004 |
Altered membrane physiology in Müller glial cells after transient ischemia of the rat retina.
Topics: Animals; Brain Ischemia; Cell Membrane; Cells, Cultured; Down-Regulation; Female; Glutamic Acid; Membrane Potentials; Nerve Degeneration; Neuroglia; Patch-Clamp Techniques; Potassium; Potassium Channels, Inwardly Rectifying; Rats; Rats, Long-Evans; Reperfusion Injury; Retina; Retinal Diseases; Sodium Channels | 2005 |
Astrocytic function assessed from 1-14C-acetate metabolism after temporary focal cerebral ischemia in rats.
Topics: Acetates; Animals; Astrocytes; Blood Gas Analysis; Cerebral Cortex; Glutamic Acid; Glutamine; Hemodynamics; Infarction, Middle Cerebral Artery; Ischemic Attack, Transient; Male; Neostriatum; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2005 |
The effect of global brain ischemia in normal and diabetic animals: the influence of calcium channel blockers.
Topics: Adenosine Triphosphate; Animals; Brain Chemistry; Brain Ischemia; Calcium; Calcium Channel Blockers; Diabetes Mellitus, Experimental; Felodipine; Glutamic Acid; Lactic Acid; Male; Rats; Rats, Wistar; Reperfusion Injury; Water | 2004 |
Extracellular correlates of glutamate toxicity in short-term cerebral ischemia and reperfusion: a direct in vivo comparison between white and gray matter.
Topics: Adenosine; Amino Acids; Animals; Brain; Brain Chemistry; Calcium; Cats; Cerebrovascular Circulation; Extracellular Space; gamma-Aminobutyric Acid; Glutamic Acid; Male; Microdialysis; Purines; Reperfusion Injury | 2005 |
Impact of high glucose/high insulin and dichloroacetate treatment on carbohydrate oxidation and functional recovery after low-flow ischemia and reperfusion in the isolated perfused rat heart.
Topics: Animals; Carbohydrate Metabolism; Carbon Radioisotopes; Dichloroacetic Acid; Glucose; Glutamic Acid; In Vitro Techniques; Insulin; Magnetic Resonance Imaging; Male; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Treatment Outcome | 2005 |
Does dietary ornithine alpha-ketoglutarate supplementation protect the liver against ischemia-reperfusion injury?
Topics: Animals; Enzyme Inhibitors; Glutamic Acid; In Vitro Techniques; Liver; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Ornithine; Oxidative Stress; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2005 |
Effects of gingko biloba extract on glutamate-induced [Ca2+]i changes in cultured cortical astrocytes after hypoxia/reoxygenation, H2O2 or L-glutamate injury.
Topics: Animals; Astrocytes; Calcium; Cell Hypoxia; Cells, Cultured; Cerebral Cortex; Drugs, Chinese Herbal; Ginkgo biloba; Glutamic Acid; Hydrogen Peroxide; Plant Leaves; Plants, Medicinal; Rats; Reperfusion Injury | 2005 |
Neurochemical evidence to implicate elevated glutamate in the mechanisms of high intraocular pressure (IOP)-induced retinal ganglion cell death in rat.
Topics: Animals; Apoptosis; Cell Death; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glutamic Acid; Intraocular Pressure; Male; Microdialysis; N-Methylaspartate; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type I; Ocular Hypertension; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reperfusion Injury; Retinal Ganglion Cells | 2005 |
Neuroprotective effects of tacrolimus (FK506) in a model of ischemic cortical cell cultures: role of glutamate uptake and FK506 binding protein 12 kDa.
Topics: Animals; Astrocytes; Cells, Cultured; Cerebral Cortex; Chromatography, High Pressure Liquid; Disease Models, Animal; Dose-Response Relationship, Drug; Glucose; Glutamic Acid; Immunohistochemistry; In Vitro Techniques; Neurons; Neuroprotective Agents; Rats; Rats, Wistar; Reperfusion Injury; Tacrolimus; Tacrolimus Binding Proteins | 2006 |
Protective effects of alpha-tocopherol and ischemic preconditioning on hepatic reperfusion injury.
Topics: Alanine Transaminase; alpha-Tocopherol; Animals; Antioxidants; Disease Models, Animal; Glutamic Acid; Glutathione Disulfide; Ischemic Preconditioning; Liver; Liver Diseases; Male; Malondialdehyde; Mitochondria, Liver; Mitochondrial Swelling; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2005 |
Oxygen-glucose deprivation decreases glutathione levels and glutamate uptake in rat hippocampal slices.
Topics: Amino Acid Transport System X-AG; Animals; Antioxidants; Catalase; Cell Survival; Dithiothreitol; Down-Regulation; Glutamic Acid; Glutathione; Glutathione Reductase; Hippocampus; Hypoxia-Ischemia, Brain; Male; Organ Culture Techniques; Oxidative Stress; Peroxidase; Rats; Rats, Wistar; Reperfusion Injury; Superoxide Dismutase; Synaptic Membranes; Synaptic Transmission | 2006 |
Neuroprotective effects of D-allose against retinal ischemia-reperfusion injury.
Topics: Animals; Disease Models, Animal; Female; Glucose; Glutamic Acid; Hydrogen Peroxide; Intraocular Pressure; Ion-Selective Electrodes; Neuroprotective Agents; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Retinal Diseases; Retinal Ganglion Cells | 2006 |
The metabolism of C-glucose by neurons and astrocytes in brain subregions following focal cerebral ischemia in rats.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Astrocytes; Brain; Brain Infarction; Brain Ischemia; Carbon Radioisotopes; Cell Communication; Cell Death; Disease Models, Animal; Down-Regulation; Energy Metabolism; Glucose; Glutamic Acid; Glutamine; Infarction, Middle Cerebral Artery; Male; Neurons; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2006 |
Ongoing epileptiform activity in the post-ischemic hippocampus is associated with a permanent shift of the excitatory-inhibitory synaptic balance in CA3 pyramidal neurons.
Topics: Animals; Electroencephalography; Electrophysiology; Epilepsy; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; In Vitro Techniques; Interneurons; Male; Nerve Endings; Neural Inhibition; Patch-Clamp Techniques; Pyramidal Cells; Rats; Rats, Wistar; Reperfusion Injury; Synapses; Synaptic Transmission | 2006 |
Neuroprotectant FK506 inhibits glutamate-induced apoptosis of astrocytes in vitro and in vivo.
Topics: Animals; Apoptosis; Astrocytes; Blotting, Western; Caspases; Cell Size; Cell Survival; Cells, Cultured; Cerebral Cortex; DNA Fragmentation; Enzyme Activation; Excitatory Amino Acid Antagonists; Fluorescent Dyes; Glial Fibrillary Acidic Protein; Glutamic Acid; In Situ Nick-End Labeling; Indoles; Infarction, Middle Cerebral Artery; Male; Membrane Potentials; Mitochondria; Neuroprotective Agents; Rats; Reperfusion Injury; Tacrolimus; Tetrazolium Salts; Thiazoles | 2006 |
Glutamate receptor activation evokes calpain-mediated degradation of Sp3 and Sp4, the prominent Sp-family transcription factors in neurons.
Topics: Animals; Calpain; Cells, Cultured; Cerebral Cortex; Excitatory Amino Acid Agonists; Glutamic Acid; Ischemic Attack, Transient; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Reperfusion Injury; Sp1 Transcription Factor; Sp3 Transcription Factor; Sp4 Transcription Factor | 2007 |
Effects of hypoxia/reperfusion injury on drug disposition in the rat isolated perfused liver.
Topics: Adrenergic beta-Antagonists; Animals; Aspartate Aminotransferases; Carbon Dioxide; Carbon Radioisotopes; Female; Glutamic Acid; Hypoxia; In Vitro Techniques; L-Lactate Dehydrogenase; Lidocaine; Liver; Perfusion; Propranolol; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2007 |
Hyperoxic reperfusion after global ischemia decreases hippocampal energy metabolism.
Topics: Animals; Brain Ischemia; Cardiopulmonary Resuscitation; Dogs; Energy Metabolism; Female; Glucose; Glutamic Acid; Heart Arrest; Hippocampus; Oxidative Stress; Oxygen Inhalation Therapy; Reperfusion Injury; Respiration, Artificial | 2007 |
Reperfusion accelerates acute neuronal death induced by simulated ischemia.
Topics: Acidosis, Respiratory; Animals; Apoptosis; Cell Death; Cell Membrane; Cells, Cultured; Cytoskeleton; Glucose; Glutamic Acid; Hypercapnia; Hypoxia-Ischemia, Brain; Mice; Mice, Inbred C57BL; Necrosis; Nerve Degeneration; Neurons; Neurotoxins; Potassium; Reperfusion Injury; Time Factors | 2007 |
Gene deletion and pharmacological inhibition of aldose reductase protect against retinal ischemic injury.
Topics: Aldehyde Reductase; Animals; Apoptosis; Gene Deletion; Glutamic Acid; Imidazolidines; L-Iditol 2-Dehydrogenase; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Neuroglia; Oxidative Stress; Papilledema; Pyrimidines; Reperfusion Injury; Retinal Diseases; Retinal Ganglion Cells | 2007 |
Mutations to bid cleavage sites protect hepatocytes from apoptosis after ischemia/reperfusion injury.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Apoptosis; Aspartic Acid; BH3 Interacting Domain Death Agonist Protein; Caspase 8; Glutamic Acid; Granzymes; Hepatocytes; Molecular Sequence Data; Mutation; Rats; Rats, Wistar; Reperfusion Injury | 2007 |
Neuroprotective effects of emodin-8-O-beta-D-glucoside in vivo and in vitro.
Topics: Animals; Anthraquinones; Antioxidants; Behavior, Animal; Brain; Brain Chemistry; Brain Ischemia; Cells, Cultured; Cerebral Cortex; Cerebral Infarction; Dose-Response Relationship, Drug; Fallopia japonica; Glucosides; Glutamic Acid; Male; Malondialdehyde; Neurons; Neuroprotective Agents; Rats; Rats, Wistar; Reperfusion Injury; Superoxide Dismutase | 2007 |
Glial cell-derived glutamate mediates autocrine cell volume regulation in the retina: activation by VEGF.
Topics: Animals; Cell Size; Diabetes Mellitus, Experimental; Disease Models, Animal; Glutamic Acid; Humans; Male; Neuroglia; Neurons; Rats; Rats, Long-Evans; Rats, Wistar; Receptors, Glutamate; Receptors, Purinergic; Reperfusion Injury; Retina; Vascular Endothelial Growth Factors; Water | 2008 |
alpha-Amino-3-hydroxy-5-methyl-4-isoxazole propionate attenuates glutamate-induced caspase-3 cleavage via regulation of glycogen synthase kinase 3beta.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Brain Ischemia; Caspase 3; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glutamic Acid; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Nerve Degeneration; Neuroprotective Agents; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Receptors, AMPA; Reperfusion Injury; Signal Transduction; Time Factors | 2008 |
Ischemic defects in the electron transport chain increase the production of reactive oxygen species from isolated rat heart mitochondria.
Topics: Animals; Electron Transport; Electron Transport Chain Complex Proteins; Electron Transport Complex I; Electron Transport Complex III; Glutamic Acid; Hydrogen Peroxide; Ischemic Preconditioning; Male; Mitochondria, Heart; Myocardial Ischemia; Myocardium; Oxidative Stress; Protein Synthesis Inhibitors; Rats; Rats, Inbred F344; Reactive Oxygen Species; Reperfusion Injury; Rotenone; Succinic Acid; Uncoupling Agents | 2008 |
Dimemorfan protects rats against ischemic stroke through activation of sigma-1 receptor-mediated mechanisms by decreasing glutamate accumulation.
Topics: Analysis of Variance; Animals; Brain Infarction; Brain Ischemia; Chemokine CCL2; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression Regulation; Glutamic Acid; Lipid Peroxidation; Male; Morphinans; Morpholines; NF-kappaB-Inducing Kinase; Nitric Oxide Synthase; Peroxidase; Protein Serine-Threonine Kinases; Rats; Rats, Long-Evans; Receptors, sigma; Reperfusion Injury; Sigma-1 Receptor; Signal Transduction; STAT1 Transcription Factor | 2008 |
NMDA receptor blocker ameliorates ischemia-reperfusion-induced renal dysfunction in rat kidneys.
Topics: 2-Amino-5-phosphonovalerate; Animals; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Kidney Cortex; Kidney Diseases; Kidney Medulla; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Reperfusion Injury | 2008 |
STAT3 activation protects retinal ganglion cell layer neurons in response to stress.
Topics: Adenoviridae; Animals; Cell Survival; Cells, Cultured; Cytoprotection; Disease Models, Animal; Excitatory Amino Acid Agonists; Glutamic Acid; Mice; Mice, Inbred Strains; N-Methylaspartate; Rats; Rats, Long-Evans; Reperfusion Injury; Retinal Diseases; Retinal Ganglion Cells; Retinal Vessels; STAT3 Transcription Factor; Stress, Physiological | 2008 |
Arachidonic acid and lysophosphatidylcholine modulate excitatory transmitter amino acid release from the rat cerebral cortex.
Topics: Animals; Arachidonic Acid; Aspartic Acid; Blood Gas Analysis; Cerebral Cortex; Glutamic Acid; Hydrogen-Ion Concentration; Lysophosphatidylcholines; Male; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 1995 |
Nizofenone, a neuroprotective drug, suppresses glutamate release and lactate accumulation.
Topics: Analysis of Variance; Animals; Cell Death; Glutamic Acid; Hippocampus; Imidazoles; Injections, Intraperitoneal; Ischemic Attack, Transient; Lactates; Lactic Acid; Male; Microdialysis; Neurons; Neuroprotective Agents; Pyramidal Cells; Rats; Rats, Wistar; Reperfusion Injury; Spectrometry, Fluorescence | 1994 |
BW1003C87 and NBQX but not CGS19755 reduce glutamate release and cerebral ischemic necrosis.
Topics: Analysis of Variance; Animals; Binding, Competitive; Brain Ischemia; Disease Models, Animal; Glutamic Acid; Hippocampus; Injections, Intraperitoneal; Injections, Intravenous; Male; Microdialysis; N-Methylaspartate; Necrosis; Neurons; Observer Variation; Pipecolic Acids; Prosencephalon; Pyrimidines; Quinoxalines; Random Allocation; Rats; Rats, Wistar; Receptors, AMPA; Reperfusion Injury | 1994 |
Action of trimetazidine on retina of gerbils after ischemia reperfusion insult: determination of .OH, amino acids, and electroretinogram.
Topics: Amino Acids; Animals; Aspartic Acid; Electroretinography; Female; gamma-Aminobutyric Acid; Gentisates; Gerbillinae; Glutamic Acid; Hydroxybenzoates; Hydroxyl Radical; Ischemia; Male; Reperfusion Injury; Retina; Retinal Vessels; Trimetazidine | 1994 |
Neuroprotective properties of the novel antiepileptic lamotrigine in a gerbil model of global cerebral ischemia.
Topics: Animals; Anticonvulsants; Arterial Occlusive Diseases; Behavior, Animal; Brain Chemistry; Brain Ischemia; Carotid Artery Diseases; Cell Death; Cognition; Disease Models, Animal; Gerbillinae; Glutamic Acid; Hippocampus; Lamotrigine; Male; Memory; Nerve Degeneration; Neurons; Neuroprotective Agents; Pyramidal Cells; Reperfusion Injury; Triazines | 1995 |
Spinal cord ischemia and reperfusion metabolism: the effect of hypothermia.
Topics: Adenosine Triphosphate; Animals; Aspartic Acid; Body Temperature; Combined Modality Therapy; Energy Metabolism; Glucose; Glutamates; Glutamic Acid; Heparin; Hypothermia, Induced; Intracellular Fluid; Ischemia; Lactates; Lactic Acid; Neurologic Examination; Neurotransmitter Agents; Rabbits; Reperfusion Injury; Sodium Chloride; Spinal Cord | 1994 |
Superoxide and nitric oxide cooperation in hypoxia/reoxygenation-induced neuron injury.
Topics: Animals; Brain Injuries; Cell Hypoxia; Cells, Cultured; Drug Synergism; Free Radicals; Glutamates; Glutamic Acid; Neurons; Nitric Oxide; Rats; Reperfusion Injury; Superoxides | 1993 |
Secondary elevation of extracellular neurotransmitter amino acids in the reperfusion phase following focal cerebral ischemia.
Topics: Amino Acids; Analysis of Variance; Animals; Aspartic Acid; Basal Ganglia; Cerebral Cortex; Cerebrospinal Fluid; Extracellular Space; gamma-Aminobutyric Acid; Glutamic Acid; Ischemic Attack, Transient; Male; Microdialysis; Neurotransmitter Agents; Rabbits; Regression Analysis; Reperfusion Injury; Taurine | 1996 |
Disturbances in the distribution of neurotransmitters in the rat retina after ischemia.
Topics: Animals; gamma-Aminobutyric Acid; Glutamic Acid; Immunohistochemistry; Intraocular Pressure; Ischemia; Nerve Degeneration; Neuroglia; Neurotransmitter Agents; Rats; Rats, Inbred Lew; Reperfusion Injury; Retina; Retinal Vessels; Tissue Distribution | 1996 |
Accumulation of cytotoxins during the development of seizures and edema after hypoxic-ischemic injury in late gestation fetal sheep.
Topics: Animals; Aspartic Acid; Brain Edema; Brain Ischemia; Cytotoxins; Electroencephalography; Extracellular Space; Female; Fetal Hypoxia; gamma-Aminobutyric Acid; Gestational Age; Glutamic Acid; Hypoxia, Brain; Nitric Oxide; Pregnancy; Reperfusion Injury; Seizures; Sheep; Time Factors | 1996 |
Clenbuterol protects mouse cerebral cortex and rat hippocampus from ischemic damage and attenuates glutamate neurotoxicity in cultured hippocampal neurons by induction of NGF.
Topics: Animals; Animals, Newborn; Brain Ischemia; Cells, Cultured; Cerebral Cortex; Clenbuterol; Glutamic Acid; Hippocampus; Immunoenzyme Techniques; Immunohistochemistry; Male; Mice; Mice, Inbred Strains; Nerve Growth Factors; Neurons; Neuroprotective Agents; Neurotoxins; Rats; Rats, Inbred F344; Rats, Wistar; Reperfusion Injury | 1996 |
Differences in the amount of glutamate released by neonatal and adult synaptosomes under conditions of in vitro ischaemia/reperfusion.
Topics: Age Factors; Animals; Animals, Newborn; Brain Ischemia; Cell Hypoxia; Glutamic Acid; In Vitro Techniques; Male; Oxidative Stress; Rats; Rats, Wistar; Reperfusion Injury; Synaptosomes | 1996 |
Antigens associated with specific retinal cells are affected by ischaemia caused by raised intraocular pressure: effect of glutamate antagonists.
Topics: Animals; Antigens; Calbindin 2; Electroretinography; Excitatory Amino Acid Antagonists; Eye Proteins; Glial Fibrillary Acidic Protein; Glutamic Acid; Immunohistochemistry; Intraocular Pressure; Ischemia; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Reperfusion Injury; Retina; Retinal Vessels; S100 Calcium Binding Protein G; Thy-1 Antigens | 1996 |
[Low-energy He-Ne-laser-induced neurochemical changes during brain ischemia/reperfusion and their integral estimation using a factor analysis model].
Topics: Adenine Nucleotides; Animals; Aspartic Acid; Brain; Brain Ischemia; Factor Analysis, Statistical; Glutamic Acid; Laser Therapy; Male; Phospholipids; Rats; Reperfusion Injury | 1996 |
In vivo and in vitro experiments show that betaxolol is a retinal neuroprotective agent.
Topics: Animals; Betaxolol; Calbindin 2; Calcium; Cell Hypoxia; Cells, Cultured; Chick Embryo; Choline O-Acetyltransferase; Electroretinography; Eye; Eye Proteins; Glutamic Acid; L-Lactate Dehydrogenase; Neurons; Neuroprotective Agents; Neurotoxins; Oxygen; Rabbits; Rats; Rats, Inbred Strains; Reperfusion Injury; Retinal Ganglion Cells; S100 Calcium Binding Protein G; Sympatholytics | 1997 |
In vitro ischemia promotes glutamate-mediated free radical generation and intracellular calcium accumulation in hippocampal pyramidal neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Brain Ischemia; Calcium; Cell Hypoxia; Energy Metabolism; Fluorescent Dyes; Free Radicals; Glucose; Glutamic Acid; Hippocampus; Ion Transport; Membrane Potentials; Oxidative Stress; Oxygen; Patch-Clamp Techniques; Pyramidal Cells; Rats; Rats, Wistar; Receptors, Glutamate; Reperfusion Injury; Rhodamine 123; Rhodamines | 1997 |
Suppression of hyperemia after brain ischemia by L-threo-3,4-dihydroxyphenylserine.
Topics: Animals; Brain Ischemia; Cell Count; Cell Survival; Droxidopa; Gerbillinae; Glutamic Acid; Hippocampus; Hyperemia; Laser-Doppler Flowmetry; Male; Microdialysis; Regional Blood Flow; Reperfusion Injury; Time Factors | 1998 |
Hypothermia prevents biphasic glutamate release and corresponding neuronal degeneration after transient spinal cord ischemia in the rat.
Topics: Animals; Combined Modality Therapy; Denervation; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Hypothermia, Induced; Injections, Spinal; Male; Microdialysis; Nerve Degeneration; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reperfusion Injury; Spinal Cord | 1999 |
Neither L-NAME nor L-arginine changes extracellular glutamate elevation and anoxic depolarization during global ischemia and reperfusion in rat.
Topics: Animals; Arginine; Cerebrovascular Circulation; Corpus Striatum; Electrophysiology; Enzyme Inhibitors; Extracellular Space; Glutamic Acid; Hypoxia; Ischemic Attack, Transient; Male; NG-Nitroarginine Methyl Ester; Rats; Rats, Wistar; Reperfusion Injury | 1999 |
The role of glutamine in skeletal muscle ischemia/reperfusion injury in the rat hind limb model.
Topics: Animals; Creatine Kinase; Disease Models, Animal; Glutamic Acid; Glutamine; Glutathione; Hindlimb; Injections, Intraperitoneal; Ischemia; Lipid Peroxidation; Male; Muscle, Skeletal; Neutrophils; Oxidative Stress; Peroxidase; Protective Agents; Random Allocation; Rats; Rats, Inbred Strains; Reperfusion Injury; Single-Blind Method; Time Factors | 1999 |
The relationship between the apparent diffusion coefficient measured by magnetic resonance imaging, anoxic depolarization, and glutamate efflux during experimental cerebral ischemia.
Topics: Animals; Brain Ischemia; Diffusion; Electrophysiology; Glutamic Acid; Hypoxia; Magnetic Resonance Imaging; Male; Rats; Rats, Wistar; Reperfusion Injury | 2000 |
Blockade of NAALADase: a novel neuroprotective strategy based on limiting glutamate and elevating NAAG.
Topics: Animals; Carboxypeptidases; Dipeptides; Glutamate Carboxypeptidase II; Glutamic Acid; Infarction, Middle Cerebral Artery; Neuroprotective Agents; Organophosphorus Compounds; Rats; Reperfusion Injury | 1999 |
Hypoxic but not ischemic neurotoxicity of free radicals revealed by dynamic changes in glucose metabolism of fresh rat brain slices on positron autoradiography.
Topics: Animals; Autoradiography; Brain; Cerebrovascular Circulation; Cyclic N-Oxides; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Fluorodeoxyglucose F18; Free Radicals; Glucose; Glutamic Acid; Hypoxia, Brain; In Vitro Techniques; Ischemic Attack, Transient; Male; Neurotoxins; Nitrogen Oxides; Oxygen; Radionuclide Imaging; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Spin Labels | 2000 |
Cerebral oligaemia episode triggers free radical formation and late cognitive deficiencies.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Aspartic Acid; Carotid Stenosis; Cognition Disorders; Corpus Striatum; Disease Models, Animal; Dopamine; Escape Reaction; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Homovanillic Acid; Hydroxybenzoates; Hydroxyl Radical; Ischemic Attack, Transient; Learning Disabilities; Male; Maze Learning; Memory Disorders; Microdialysis; Oxidative Stress; Psychomotor Performance; Rats; Rats, Wistar; Reaction Time; Reperfusion Injury; Spatial Behavior; Swimming; Time Factors | 2000 |
Topical glucose and accumulation of excitotoxic and other amino acids in ischemic cerebral cortex.
Topics: Animals; Aspartic Acid; Blood Pressure; Brain Ischemia; Carbon Dioxide; Cerebral Cortex; Ethanolamines; Excitatory Amino Acids; gamma-Aminobutyric Acid; Glucose; Glutamic Acid; Hyperglycemia; Male; Oxygen; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Taurine | 2000 |
Quantitative evaluation of extracellular glutamate concentration in postischemic glutamate re-uptake, dependent on brain temperature, in the rat following severe global brain ischemia.
Topics: Animals; Body Temperature; Brain; Cerebrovascular Circulation; Cytoplasm; Disease Models, Animal; Extracellular Space; Glutamic Acid; Hypoxia-Ischemia, Brain; Male; Neurons; Rats; Rats, Wistar; Regional Blood Flow; Reperfusion Injury | 2000 |
NOC/oFQ contributes to hypoxic-ischemic impairment of N-methyl-D-aspartate-induced cerebral vasodilation.
Topics: Animals; Animals, Newborn; Blood Gas Analysis; Blood Pressure; Brain Ischemia; Cerebrovascular Circulation; Excitatory Amino Acid Agonists; Female; Glutamic Acid; Hypoxia, Brain; Male; N-Methylaspartate; Nociceptin; Opioid Peptides; Pia Mater; Receptors, N-Methyl-D-Aspartate; Reperfusion Injury; Swine; Vasodilation | 2000 |
Transporter reversal as a mechanism of glutamate release from the ischemic rat cerebral cortex: studies with DL-threo-beta-benzyloxyaspartate.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding Cassette Transporters; Brain Ischemia; Cerebral Cortex; Glutamic Acid; Hydrogen-Ion Concentration; Lactic Acid; Male; Neurotoxins; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Taurine | 2000 |
Lomerizine, a Ca2+ channel blocker, reduces glutamate-induced neurotoxicity and ischemia/reperfusion damage in rat retina.
Topics: Animals; Calcium Channel Blockers; Cells, Cultured; Dizocilpine Maleate; Dose-Response Relationship, Drug; Flunarizine; Glutamic Acid; Male; Neuroprotective Agents; Neurotoxicity Syndromes; Piperazines; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2000 |
The effect of intravenous insulin on accumulation of excitotoxic and other amino acids in the ischemic rat cerebral cortex.
Topics: Animals; Aspartic Acid; Brain Chemistry; Cerebral Cortex; Energy Metabolism; gamma-Aminobutyric Acid; Glucose; Glutamic Acid; Glycogen; Hypoglycemia; Hypoglycemic Agents; Injections, Intravenous; Insulin; Ischemic Attack, Transient; Lactic Acid; Male; Neurotoxins; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Taurine | 2000 |
Protective effect of gamma-glutamylethylamide (theanine) on ischemic delayed neuronal death in gerbils.
Topics: Animals; Brain Ischemia; Cell Count; Cell Death; Excitatory Amino Acid Antagonists; Gerbillinae; Glutamates; Glutamic Acid; Hippocampus; Nerve Degeneration; Neurons; Neuroprotective Agents; Reperfusion Injury | 2000 |
DOPA cyclohexyl ester, a competitive DOPA antagonist, protects glutamate release and resultant delayed neuron death by transient ischemia in hippocampus CA1 of conscious rats.
Topics: Animals; Brain Ischemia; Cell Death; Dihydroxyphenylalanine; Glutamic Acid; Hippocampus; Levodopa; Male; Nerve Degeneration; Neurons; Neuroprotective Agents; Organ Culture Techniques; Rats; Rats, Wistar; Reperfusion Injury | 2001 |
Characterization of transient focal ischemia-induced increases in extracellular glutamate and aspartate in spontaneously hypertensive rats.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding Cassette Transporters; Brain; Brain Ischemia; Extracellular Space; Glutamic Acid; Infarction, Middle Cerebral Artery; Kainic Acid; Male; Rats; Rats, Inbred SHR; Reperfusion Injury; Tetrodotoxin; Time Factors | 2000 |
The effect of streptozotocin-induced diabetes on the release of excitotoxic and other amino acids from the ischemic rat cerebral cortex.
Topics: Acute Disease; Amino Acids; Animals; Blood Glucose; Brain Ischemia; Cerebral Cortex; Chronic Disease; Diabetes Mellitus, Experimental; Extracellular Space; gamma-Aminobutyric Acid; Glutamic Acid; Lactic Acid; Male; Neurotoxins; Rats; Rats, Sprague-Dawley; Reference Values; Reperfusion Injury | 2001 |
A novel neuronal cell protecting substance mescengricin produced by Streptomyces griseoflavus.
Topics: Animals; Brain; Brain Ischemia; Carbolines; Cell Death; Cells, Cultured; Chick Embryo; Glutamic Acid; Magnetic Resonance Spectroscopy; Models, Chemical; Neurons; Neuroprotective Agents; Rats; Reperfusion Injury; Streptomyces; Structure-Activity Relationship | 2000 |
Increased extracellular ascorbate release reflects glutamate re-uptake during the early stage of reperfusion after forebrain ischemia in rats.
Topics: Animals; Antioxidants; Ascorbic Acid; Biosensing Techniques; Extracellular Space; Glutamic Acid; Ischemic Attack, Transient; Male; Microdialysis; Prosencephalon; Rats; Rats, Wistar; Reperfusion Injury; Time Factors | 2001 |
Lubeluzole inhibits accumulation of extracellular glutamate in the hippocampus during transient global cerebral ischemia.
Topics: Action Potentials; Animals; Body Temperature; Brain Ischemia; Cardiovascular Physiological Phenomena; Extracellular Space; Glutamic Acid; Hippocampus; Microdialysis; Nerve Degeneration; Neurons; Neuroprotective Agents; Piperidines; Rabbits; Reperfusion Injury; Respiratory Physiological Phenomena; Thiazoles | 2001 |
Hypothermia reduces glutamate efflux in perilymph following transient cochlear ischemia.
Topics: Animals; Cochlea; Cochlear Diseases; Deafness; Disease Models, Animal; Female; Gerbillinae; Glutamic Acid; Hair Cells, Auditory, Inner; Hypothermia, Induced; Ischemic Attack, Transient; Microscopy, Electron; Neurons, Afferent; Perilymph; Reperfusion Injury; Synapses; Vertebrobasilar Insufficiency | 2001 |
Middle cerebral artery occlusion and reperfusion in primates monitored by microdialysis and sequential positron emission tomography.
Topics: Animals; Brain; Brain Ischemia; Cerebrovascular Circulation; Glutamic Acid; Hypoxanthine; Infarction, Middle Cerebral Artery; Lactic Acid; Macaca mulatta; Microdialysis; Oxygen Consumption; Pyruvic Acid; Reperfusion Injury; Tomography, Emission-Computed | 2001 |
Increase of interstitial glycerol reflects the degree of ischaemic brain damage: a PET and microdialysis study in a middle cerebral artery occlusion-reperfusion primate model.
Topics: Animals; Brain Damage, Chronic; Extracellular Space; Glutamic Acid; Glycerol; Infarction, Middle Cerebral Artery; Lactic Acid; Macaca mulatta; Microdialysis; Oxygen Consumption; Phospholipids; Pyruvic Acid; Reperfusion Injury; Tomography, Emission-Computed | 2001 |
Effect of hyperbaric oxygen on striatal metabolites: a microdialysis study in awake freely moving rats after MCA occlusion.
Topics: Animals; Brain Ischemia; Corpus Striatum; Energy Metabolism; Extracellular Space; Glucose; Glutamic Acid; Hyperbaric Oxygenation; Infarction, Middle Cerebral Artery; Lactic Acid; Male; Microdialysis; Movement; Neurons; Pyruvic Acid; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Time Factors; Wakefulness | 2001 |
[Effect of guizhi fuling pills on the changes of Ca2+ and amino acids in rats with cerebral ischemia and reperfusion].
Topics: Animals; Brain; Brain Ischemia; Calcium; Drug Combinations; Drugs, Chinese Herbal; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Male; Random Allocation; Rats; Reperfusion Injury | 1998 |
Different dynamic patterns of extracellular glutamate release in rat hippocampus after permanent or 30-min transient cerebral ischemia and histological correlation.
Topics: Animals; Astrocytes; Brain; Brain Ischemia; Extracellular Space; Glutamic Acid; Hippocampus; Male; Microdialysis; Necrosis; Nerve Degeneration; Neurons; Rats; Rats, Wistar; Reperfusion Injury; Up-Regulation | 2001 |
Oxygen radicals in cerebral ischemia: the 2001 Willis lecture.
Topics: Animals; Brain Ischemia; Cats; Cerebrovascular Circulation; Glutamic Acid; Humans; Nitric Oxide Synthase; Reactive Oxygen Species; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Reperfusion Injury; Vasodilation | 2001 |
Differential regulation of glial cell line-derived neurotrophic factor (GDNF) mRNA expression during hypoxia and reoxygenation in astrocytes isolated from stroke-prone spontaneously hypertensive rats.
Topics: Animals; Astrocytes; Brain; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Fetus; Gene Expression Regulation; Glial Cell Line-Derived Neurotrophic Factor; Glutamic Acid; Hydrogen Peroxide; Hypoxia-Ischemia, Brain; Nerve Growth Factors; Nerve Tissue Proteins; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Reperfusion Injury; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2002 |
Interleukin-1beta mediates ischemic injury in the rat retina.
Topics: Analysis of Variance; Animals; Cell Count; Cell Survival; Cells, Cultured; Choroid Plexus; Dizocilpine Maleate; Enzyme-Linked Immunosorbent Assay; Ganglia, Sensory; Glutamic Acid; Interleukin-1; Male; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Retina; Retinal Diseases | 2001 |
Effects of dantrolene on extracellular glutamate concentration and neuronal death in the rat hippocampal CA1 region subjected to transient ischemia.
Topics: Animals; Cell Death; Dantrolene; Dimethyl Sulfoxide; Extracellular Space; Glutamic Acid; Hippocampus; Injections, Intraventricular; Ischemic Attack, Transient; Male; Microdialysis; Muscle Relaxants, Central; Neurons; Neuroprotective Agents; Oxygen Consumption; Rats; Rats, Wistar; Reperfusion Injury | 2002 |
Low-dose Carbicarb improves cerebral outcome after asphyxial cardiac arrest in rats.
Topics: Acidosis; Animals; Asphyxia; Brain; Brain Ischemia; Carbonates; Cell Death; Disease Models, Animal; Drug Combinations; Glutamic Acid; Heart Arrest; Hippocampus; Neurons; Rats; Recovery of Function; Reperfusion Injury; Sodium Bicarbonate; Treatment Outcome | 2002 |
Inhibition of glial glutamate transporter GLT-1 augments brain edema after transient focal cerebral ischemia in mice.
Topics: Animals; Brain; Brain Edema; Brain Ischemia; Excitatory Amino Acid Transporter 2; Extracellular Space; Female; Glutamic Acid; Infarction, Middle Cerebral Artery; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuroglia; Neurotoxins; Neurotransmitter Uptake Inhibitors; Reperfusion Injury; Water-Electrolyte Balance | 2002 |
Effects of magnesium sulfate on energy metabolites and glutamate in the cortex during focal cerebral ischemia and reperfusion in the gerbil monitored by a dual-probe microdialysis technique.
Topics: Animals; Brain Ischemia; Cerebral Cortex; Cerebral Infarction; Energy Metabolism; Gerbillinae; Glucose; Glutamic Acid; Lactic Acid; Magnesium Sulfate; Microdialysis; Pyruvic Acid; Reperfusion Injury | 2002 |
Glutamate accumulation and increased hydroxyl free radical formation in the abdominal aorta and heart of gerbil after ischemia/reperfusion insult.
Topics: Animals; Aorta, Abdominal; Female; Free Radicals; Gentisates; Gerbillinae; Glutamates; Glutamic Acid; Hydroxides; Hydroxybenzoates; Hydroxyl Radical; Male; Myocardium; Reperfusion Injury | 1992 |
Effect of dichloroacetate on recovery of brain lactate, phosphorus energy metabolites, and glutamate during reperfusion after complete cerebral ischemia in rats.
Topics: Adenosine Triphosphate; Animals; Brain Ischemia; Cations; Dichloroacetic Acid; Disease Models, Animal; Glutamates; Glutamic Acid; Hydrogen-Ion Concentration; Lactates; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Phosphocreatine; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Water | 1992 |
Protective effect of synaptic inhibition during cerebral ischemia in rats and rabbits.
Topics: Animals; Brain Ischemia; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Learning; Male; Muscimol; Rabbits; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 1992 |
Critical levels of extracellular glutamate mediating gerbil hippocampal delayed neuronal death during hypothermia: brain microdialysis study.
Topics: Animals; Body Temperature; Cell Death; Dialysis; Extracellular Space; Gerbillinae; Glutamates; Glutamic Acid; Hippocampus; Hyperthermia, Induced; Hypothermia, Induced; Ischemic Attack, Transient; Male; Microchemistry; Neurons; Reperfusion Injury | 1991 |