glutamic acid has been researched along with Infarction, Middle Cerebral Artery in 163 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (0.61) | 18.2507 |
| 2000's | 68 (41.72) | 29.6817 |
| 2010's | 80 (49.08) | 24.3611 |
| 2020's | 14 (8.59) | 2.80 |
| Authors | Studies |
|---|---|
| Gupta, S; Kumar, M; Kushwah, AS; Singh, G; Singh, TG; Surampalli, G | 1 |
| Baukov, YI; Borisevich, SS; Borozdenko, DA; Chekhonin, VP; Cherkashova, EA; Ezdoglian, AA; Golubev, YV; Gonchar, DI; Gubskiy, IL; Gubsky, LV; Gureev, MA; Kiseleva, NM; Lagunin, AA; Lyakhmun, DN; Namestnikova, DD; Negrebetsky, VV; Shagina, AD; Shmigol, TA; Tarasenko, DV | 1 |
| Azami Tameh, A; Karimian, M; Khassafi, N; Vahidinia, Z; Zahraei, Z | 1 |
| Wang, F; Zhang, X; Zhou, H | 1 |
| Cheng, T; Gu, Y; Huang, P; Li, H; Liu, A; Sun, Y; Wu, G; Yang, J; Ye, J; Zhao, J | 1 |
| Kang, JB; Koh, PO; Park, DJ | 1 |
| Kang, JB; Koh, PO | 1 |
| Choi, M; Hwang, EM; Jung, HG; Kim, A; Kim, SC; Lee, SG; Park, JY | 1 |
| Jin, YB; Kang, JB; Koh, PO; Park, DJ; Shah, FA | 1 |
| Wei, W; Yue, Y; Zhang, Y; Zhao, H | 1 |
| Chen, SR; Luo, Y; Pan, HL; Sah, R; Shao, JY; Zhou, JJ | 1 |
| Gakare, S; Kumar, R; Mahale, A; Prakash, A; Sarode, LP; Ugale, RR | 1 |
| Kim, WK; Ko, YU; Oh, YJ; Song, HY; Yun, N; Yune, TY | 1 |
| Gim, SA; Kang, JB; Koh, PO; Park, DJ; Shah, FA | 1 |
| Cheng, G; Huang, M; Qin, R; Tan, H; Wang, Y; Zhang, Y; Zou, Y | 1 |
| Anderton, RS; Blacker, DJ; Clark, VW; Cross, JL; Edwards, AB; Knuckey, NW; Meloni, BP; Milani, D | 1 |
| Budziszewska, B; Bystrowska, B; Filip, M; Krzyżanowska, W; Pera, J; Pomierny, B; Pomierny-Chamioło, L | 1 |
| Gan, Y; Gao, F; Ghanian, S; Gong, G; Han, P; Liu, Q; Tang, Z; Wang, J; Yin, J | 1 |
| Cao, H; Duan, J; Guo, L; Li, B; Sun, L; Zhang, Q; Zhu, B; Zhu, H | 1 |
| Gu, J; Li, C; Liu, W; Long, C; Shan, L; Sun, Y; Wang, Y; Wu, L; Xu, L; Yang, X; Zhang, G; Zhang, T; Zhang, Z; Zhou, X | 1 |
| Chen, Z; Dai, M; Kang, F; Meng, Y; Wang, X; Yu, H | 1 |
| Jiao, S; Li, Y; Liu, B; Yang, Y; Zhang, J; Zhang, X; Zhao, Y | 1 |
| Ceanga, M; Couillard-Després, S; Frahm, C; Geis, C; Grünewald, B; Haselmann, H; Keiner, S; Kunze, A; Redecker, C; Witte, OW | 1 |
| Kang, JB; Koh, PO; Park, DJ; Shah, MA | 1 |
| Boyko, M; Brotfain, E; Frank, D; Grinshpun, Y; Gruenbaum, BF; Kuts, R; Natanel, D; Shelef, I; Tsenter, P; Zlotnik, A; Zvenigorodsky, V | 1 |
| Fang, JQ; Jia, HY; Liu, J; Mao, QY; Wu, YY; Yu, XL | 1 |
| Bonova, P; Burda, J; Danielisova, V; Gottlieb, M; Nemethova, M | 2 |
| Ally, A; Maher, TJ; Phattanarudee, S; Towiwat, P | 1 |
| Klein, J; Koch, KA; Schwarzkopf, TM | 1 |
| Eckert, GP; Hagl, S; Klein, J; Schwarzkopf, TM | 1 |
| Arunachalam, P; Bernreuther, C; Daehn, T; Friese, MA; Gelderblom, M; Gerloff, C; Glatzel, M; Ludewig, P; Magnus, T; Matschke, J; Schattling, B | 1 |
| He, Y; Li, F; Liu, J; Liu, K; Shi, W; Wang, Z; Wei, X; Xu, H; Yang, F; Yi, F; Zhang, H; Zhang, X; Zhang, Y; Zhu, T | 1 |
| Canals, S; Godino, Mdel C; Lerma, J; Lizasoain, I; Moro, MA; Pacheco, J; Romera, VG; Sánchez-Prieto, J; Sánchez-Tomero, JA; Torres, M; Vivancos, J | 1 |
| Bi, M; Gladbach, A; Ittner, LM; Ke, YD; van Eersel, J | 1 |
| Chen, J; Du, G; Li, J; Li, X; Miao, Z; Pei, A; Tu, H; Wang, C; Xie, H; Xu, X; Zhao, H | 1 |
| Allen, RS; Boatright, JH; Cale, HA; Morrison, KC; Pardue, MT; Sayeed, I; Stein, DG | 1 |
| Camós, S; Cañadas, R; Castellanos, M; Gubern, C; Hurtado, O; Lizasoain, I; Mallolas, J; Moro, MA; Rodríguez, R; Romera, VG; Serena, J; Sobrado, M | 1 |
| Chin, K; Liu, F; Wang, M; Zhai, D | 1 |
| Koh, PO | 6 |
| Chen, J; Chen, W; Hu, H; Huang, Y; Leng, T; Liu, A; Qiu, P; Sang, H; Tang, L; Wang, L; Wang, Y; Yan, G; Yin, W; You, X; Zhang, J; Zhou, Y | 1 |
| Bie, XD; Ge, LJ; Han, J; Wan, HT; Yang, JH; Zhang, YY | 1 |
| Bowens, NH; Dohare, P; Feustel, PJ; Hyzinski-García, MC; Jourd'heuil, D; Keller, RW; Mongin, AA; Nalwalk, JW; Vipani, A | 1 |
| Bhattacharya, P; Pandey, AK; Patnaik, R; Paul, S | 1 |
| Chen, XY; Huang, YJ; Leng, TD; Liu, AL; Ou, YQ; Qiu, PX; Su, XW; Tang, LP; Yan, GM; Yan, M; Yin, W; Zhang, JX; Zhou, SJ | 1 |
| Cai, D; Cai, Y; Gao, J; Wang, L; Wei, X; Xiang, J; You, J; Zhou, Z | 1 |
| Jia, S; Wang, L; Xia, Q; Zhang, B | 1 |
| Fu, Q; Li, J; Li, S; Li, Y; Liu, B; Ma, S; Wang, X | 1 |
| DiNapoli, VA; Gerhardt, GA; Hartings, JA; Hinzman, JM; Mahoney, EJ | 1 |
| Han, L; Hao, S; Hou, Z; Li, YV; Liu, B; Pei, L; Tian, Q; Tian, R; Yan, H; Zhang, Q | 1 |
| Bona, M; Bonova, P; Danielisova, V; Gottlieb, M; Matiasova, M; Nemethova, M | 1 |
| Klein, J; Koch, K; Schwarzkopf, TM | 1 |
| Anita, A; Kalaivani, P; Pramila, B; Saravana Babu, C | 1 |
| Ahn, KC; Dunbar, GL; Hall, TC; Learman, CR; MacKenzie, EM; Song, MS; Weaver, CL | 1 |
| Ding, X; Dong, X; Song, C; Wu, X; Zheng, L | 1 |
| Gan, Y; Han, P; Li, S; Li, Y; Liu, Q; Shi, J; Tang, Z; Wang, C; Wang, J; Yin, J | 1 |
| Liu, B; Lou, Z; Luo, XJ; Peng, J; Peng, JJ; Ren, KD; Ren, X; Tan, B; Xiong, XM; Yang, ZB; Zhang, XJ | 1 |
| Chang, S; Gao, Y; Huang, Z; Li, J; Li, P; Liao, H; Pang, T; Ran, S; Saavedra, JM; Wang, Y; Xu, X; Xu, Y; Zhang, L | 1 |
| Chen, X; Hu, H; Huang, Y; Leng, T; Li, Q; Liu, A; Qiu, P; Su, X; Wang, Y; Xiong, ZG; Yan, G; Yin, W; Zhang, J; Zhou, S; Zhou, Y; Zhu, W | 1 |
| Gao, F; Li, P; Shen, M; Teng, F; Wu, J; Zhang, C; Zhang, J | 1 |
| Gu, Z; Hu, Q; Jiang, Y; Liu, X; Liu, Y; Lv, L; Lv, W; Sun, W; Wang, B; Wang, Z; Xin, H; Xu, Q; Zhao, Y | 1 |
| Carlson, HL; Damji, O; Hererro, M; Hodge, J; Jadavji, Z; Kirton, A; MacMaster, FP; Mazur-Mosiewicz, A; Mineyko, A; Nowak, M; Patzelt, R; Saunders, J | 1 |
| Greig, NH; Li, Y; Tamargo, IA; Wang, Y; Wu, KJ; Yu, SJ | 1 |
| Abrams, SR; Benson, CL; Han, X; Hou, ST; Jiang, SX; Slinn, J; Zaharia, LI | 1 |
| Gnyawali, S; Harris, H; Khanna, S; Rink, C; Roy, S; Sen, CK; Stewart, R; Teplitsky, S | 1 |
| Biswal, S; Christen, Y; Doré, S; Saleem, S; Zhuang, H | 1 |
| Bin Din, L; Franke, K; Häke, I; Ismail, G; Latiff, A; Neumann, J; Paulsen-Merker, K; Reymann, K; Said, IM; Schönenberger, S; Ullrich, O; Wessjohann, L; Zipp, F | 1 |
| Berthet, C; Gruetter, R; Hirt, L; Lei, H | 1 |
| Cao, ZJ; Hu, YS; Jia, J; Liu, G; Wu, Y; Xia, CM; Yu, HX; Zheng, QP; Zhu, DN | 1 |
| Halliwell, RF; Khansari, PS | 1 |
| Furuta, K; Hokamura, K; Ibaraki, K; Maeda, M; Suzuki, M; Thura, M; Umemura, K; Yamamoto, S | 1 |
| Amantea, D; Bagetta, G; Corasaniti, MT; Fratto, V; Maida, S; Nappi, G; Ragusa, S; Rotiroti, D | 1 |
| Böger, RH; Choe, CU; Donzelli, S; Espey, MG; Fischer, G; Gerloff, C; Hewett, SJ; Hummel, FC; King, SB; Lewerenz, J; Magnus, T; Schwedhelm, E; Uliasz, TF | 1 |
| Chang, HC; Wang, RY; Wang, SG; Yang, YR | 1 |
| Aylsworth, A; Ferguson, G; Hou, ST; Hu, H; Jiang, SX; Kaibuchi, K; Kappler, J; Leung, T; Slinn, J | 1 |
| Chen, H; Jiang, Y; Li, C; Li, H; Yan, Z; Yang, J; Zhang, Z | 1 |
| Chen, Z; Fan, YY; He, P; Hu, WW; Ohtsu, H; Shen, Y; Yan, HJ; Zhang, JX | 1 |
| Chen, ZQ; Jiang, ZL; Li, X; Peng, LL; Wang, GH | 1 |
| Dabrowski, M; Gozdz, A; Kaminska, B; Szydlowska, K; Zawadzka, M | 1 |
| Alborch, E; Arce, C; Burguete, MC; Cañadas, S; Castelló-Ruiz, M; González, MP; Oset-Gasque, MJ; Roncero, C; Salom, JB; Sánchez-Mendoza, E; Torregrosa, G | 1 |
| Cao, ZJ; Guo, QC; Hu, YS; Jia, J; Liu, G; Wu, Y; Xia, CM; Yu, HX; Zhang, X; Zhu, DN | 1 |
| Hsieh, CL; Lin, YW | 1 |
| Ji, X; Li, F; Lu, W; Luo, CX; Wu, HY; Xu, HB; Zhou, L; Zhou, QG; Zhu, DY; Zhu, MM | 1 |
| Goyagi, T; Nishikawa, T; Tobe, Y | 1 |
| Agulla, J; Argibay, B; Brea, D; Campos, F; Castillo, J; Pérez-Mato, M; Ramos-Cabrer, P; Rodríguez-González, R; Sobrino, T | 1 |
| Culmsee, C; D'Orsi, B; Dolga, AM; Eisel, UL; Kepura, F; Knaus, HG; Nijholt, IM; Plant, T; Plesnila, N; Prehn, JH; Terpolilli, N | 1 |
| Feng, W; Li, J; Li, SX; Wang, H; Yang, ZZ | 1 |
| Bai, Y; Chen, L; Li, L; Qi, J; Qi, Z; Sun, K; Yang, R; Zhang, Z; Zhou, L | 1 |
| An, J; Chan, CB; Hao, C; Liu, X; Luo, HR; Pradoldej, S; Ye, K; Yepes, M | 1 |
| Fanne, RA; Heyman, SN; Higazi, AA; Hijazi, N; Nassar, T | 1 |
| Alf, MF; Berthet, C; Gruetter, R; Hirt, L; Lei, H; Mlynarik, V | 1 |
| Bahr, BA; Carvalho, AL; Catarino, T; Duarte, CB; Fernandez, P; Gomes, JR; Inácio, AR; Lobo, AC; Mele, M; Santos, AE; Wieloch, T | 1 |
| Boyko, M; Gruenbaum, BF; Gruenbaum, SE; Kuts, R; Melamed, I; Ohayon, S; Regev, A; Shapira, Y; Teichberg, VI; Zlotnik, A | 1 |
| Hara, T; Konishi, S; Nakazato, R; Takarada, T; Yoneda, Y | 1 |
| Babu, CS; Justin, A; Ramanathan, M; Shanthakumari, S | 1 |
| Chen, HY; Chen, TY; Hung, YC; Lee, EJ; Lee, WT; Lin, MH; Tai, SH; Wu, TS | 1 |
| Ambrosino, P; Annunziato, L; Bonanno, G; Caliendo, G; Cantile, M; Cuomo, O; Di Renzo, G; Fiorino, F; Gatta, E; Milanese, M; Molinaro, P; Pannaccione, A; Pignataro, G; Robello, M; Santagada, V; Scorziello, A; Secondo, A; Severino, B; Sisalli, MJ | 1 |
| Bian, X; Chen, S; Hu, Z; Liu, X; Wang, K; Wang, Y; Zhang, X; Zhu, Y | 1 |
| Chen, Z; Fan, YY; He, P; Hu, WW; Shen, Y; Shen, Z; Wang, XF; Zhang, XN | 1 |
| Carbonell, T; Castellanos, M; Castillo, J; Dávalos, A; Martinez, J; Puig, N; Rama, R | 1 |
| Cai, ZY; Covey, DF; Day, AL; Eberst, K; Liu, R; Perez, E; Prokai, L; Prokai-Tatrai, K; Simpkins, JW; Wu, SS; Yang, SH; Yi, KD | 1 |
| Ally, A; Maher, TJ; Nauli, SM | 1 |
| Bruhn, T; Christensen, T; Diemer, NH | 1 |
| Liu, GQ; Sheng, R | 1 |
| Cárdenas, A; Colado, MI; De Cristóbal, J; Hurtado, O; Leza, JC; Lizasoain, I; Lorenzo, P; Moro, MA; Pereira, MP; Sánchez, V | 1 |
| Chen, M; Guo, G; He, M; Jiang, X; Wang, J; Zhang, M; Zheng, Y | 1 |
| Berger, C; Dohmen, C; Graf, R; Maurer, MH; Schwab, S | 1 |
| Albert, M; Bagdy, E; Gigler, G; Hársing, LG; Jurányi, Z; Király, I; Ling, I; Móricz, K; Simó, A; Sólyom, S; Szénási, G; Varga, A | 1 |
| Feustel, PJ; Jin, Y; Kimelberg, HK | 1 |
| Connell, BJ; Cribb, AE; Legge, C; Saleh, TM | 1 |
| Berger, C; Kiening, KL; Sakowitz, OW; Schwab, S | 1 |
| Helps, SC; Nilsson, M; Sims, NR; Thoren, AE | 2 |
| Burbidge, SA; Chapman, DM; Facci, L; Hunter, AJ; Irving, EA; Parsons, AA; Roberts, JC; Rosin, C; Skaper, SD; Vinson, M; Virley, DJ; Walsh, FS | 1 |
| Alborch, E; Burguete, MC; Castillo, J; Hurtado, O; Knowles, RG; Leza, JC; Lizasoain, I; Lorenzo, P; Moro, MA; Pérez-Asensio, FJ; Salom, JB; Torregrosa, G | 1 |
| Hara, H; Morimoto, N; Nagai, H; Shimazawa, M; Yamashima, T | 1 |
| Blanco, M; Castellanos, M; Castillo, J; Dávalos, A; Leira, R; Lizasoain, I; Moro, MA; Serena, J; Silva, Y; Vivancos, J | 1 |
| Alonso-Escolano, D; Cárdenas, A; Fernández-Tomé, P; Hurtado, O; Lizasoain, I; Lorenzo, P; Moro, MA; Pradillo, JM; Romera, C | 1 |
| Abe, J; Igarashi, K; Iida, Y; Kasuya, F; Kitamura, Y; Mifune, M; Ohta, M; Saito, Y; Saji, H; Ueda, M | 1 |
| Fu, FH; Li, CL; Liu, K; Tian, JW; Wang, ZH; Zhu, HB | 1 |
| Cho, JH; Koh, PO; Won, CK | 1 |
| Kaminska, B; Szydlowska, K; Zawadzka, M | 1 |
| Hurtado, O; Lizasoain, I; Lorenzo, P; Mallolas, J; Morales, JR; Moro, MA; Nombela, F; Pereira, MP; Romera, A; Romera, C; Serena, J; Vivancos, J | 1 |
| Chen, L; Si, J; Xia, Z | 1 |
| Zeng, X; Zhang, S; Zhang, Y; Zheng, X | 1 |
| Abe, K; Egashira, N; Fujioka, M; Fujiwara, M; Hasebe, N; Hayakawa, K; Hazekawa, M; Irie, K; Iwasaki, K; Mishima, K; Nozako, M; Orito, K | 1 |
| Bernardi, G; Calabresi, P; Centonze, D; De Chiara, V; Picconi, B; Prosperetti, C; Rossi, S; Tortiglione, A | 1 |
| de Brum-Fernandes, AJ; Doré, S; Maruyama, T; Narumiya, S; Saleem, S; Zhuang, H | 1 |
| Bei, W; Hu, D; Peng, W; Xie, Z; Xu, A; Zang, L | 1 |
| Alborch, E; Castillo, J; Fernández-López, D; Hurtado, O; Lizasoain, I; Morales, JR; Moro, MA; Pradillo, JM; Sobrino, T | 1 |
| Moskowitz, MA; Nishimura, M; Qiu, J; Qiu, S; Salomone, S; Savitz, SI; Sims, JR; Wang, Y | 1 |
| Coimbra, NC; Colli, BO; Coutinho Netto, J; Silva, MN | 1 |
| Ayoub, I; Bastan, B; Beal, MF; Cho, S; D'Annibale, MA; Fisher, M; Ko, B; Langley, B; Ratan, RR; Suh, K; Tolhurst, A; Yang, L | 1 |
| Feustel, PJ; Kimelberg, HK; Zhang, H; Zhang, Y | 1 |
| Blank, T; Han, JL; Kollmar, R; Schwab, S; Tobyas, B | 1 |
| Berger, C; Kiening, K; Schwab, S | 1 |
| Alonso, A; Fatar, M; Griebe, M; Hennerici, M; Kern, R; Kreisel, S; Meairs, S; Stroick, M | 1 |
| Jackson, P; Lu, M; Slusher, B; Tsukamoto, T; Vornov, JJ; Wang, E; Wozniak, K | 1 |
| Campbell, CA; Chapman, GA; Harrison, D; Moores, K; Stewart, BR; Strijbos, PJ | 1 |
| Kuo, JS; Lin, NN; Tsai, PJ; Yang, CS | 1 |
| Fahrig, T; Horváth, E; Jork, R; Mauler, F | 1 |
| Culmsee, C; Krieglstein, J; Schafer, MK; Stumm, R; Weihe, E | 1 |
| Diaz, FG; Guyot, LL; McLeod, S; O'Regan, MH; Park, H; Phillis, JW | 1 |
| Dawson, LA; Djali, S; Gonzales, C; Vinegra, MA; Zaleska, MM | 1 |
| Bowen, KK; Dempsey, RJ; Dogan, A; Kim, BT; Rao, VL; Rothstein, JD; Todd, KG | 1 |
| Andersson, J; Enblad, P; Fasth, KJ; Frykholm, P; Hillered, L; Långström, B; Persson, L; Silander, HC; Valtysson, J; Watanabe, Y | 1 |
| Brinker, G; Dohmen, C; Graf, R; Grond, M; Heiss, WD; Neveling, M; Schneweis, S; Staub, F | 1 |
| Enblad, P; Frykholm, P; Hillered, L; Långström, B; Persson, L; Valtysson, J; Watanabe, Y | 1 |
| Badr, AE; Mychaskiw, G; Yin, W; Zhang, JH | 1 |
| Caputi, L; Hainsworth, AH; Lavaroni, F; Leach, MJ; McNaughton, NC; Mercuri, NB; Randall, AD; Spadoni, F; Stefani, A; Swan, JH | 1 |
| Aschoff, A; Berger, C; Schäbitz, WR; Schellinger, PD; Schwab, S; Steiner, T | 1 |
| Håberg, A; Haraldseth, O; Qu, H; Saether, O; Sonnewald, U; Unsgård, G | 1 |
| de Groat, WC; Namiki, M; Yokoyama, O; Yoshiyama, M | 1 |
| Aschoff, A; Berger, C; Georgiadis, D; Schäbitz, WR; Schwab, S; Steiner, T | 1 |
| Jiang, XF; Kamichi, S; Maeno, H; Nagata, I; Namura, S; Takami, S; Wada, K | 1 |
| Bolay, H; Can, A; Dalkara, T; Gürsoy-Ozdemir, Y; Onur, R; Sara, Y | 1 |
| Graf, R; Heiss, WD; Toyota, S; Valentino, M; Yoshimine, T | 1 |
| Bechberger, JF; Nakase, T; Naus, CC; Ozog, MA | 1 |
3 trial(s) available for glutamic acid and Infarction, Middle Cerebral Artery
| Article | Year |
|---|---|
The prediction of malignant cerebral infarction by molecular brain barrier disruption markers.
Topics: Aged; Biomarkers; Blood-Brain Barrier; Brain; Case-Control Studies; Edema; Female; Fibronectins; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Humans; Hypothermia, Induced; Infarction, Middle Cerebral Artery; Interleukin-10; Interleukin-6; Male; Matrix Metalloproteinase 9; Middle Aged; Predictive Value of Tests; Retrospective Studies; Sensitivity and Specificity; Stroke; Time Factors; Tomography, X-Ray Computed; Treatment Outcome; Tumor Necrosis Factor-alpha | 2005 |
Predictive value of neurochemical monitoring in large middle cerebral artery infarction.
Topics: Adult; Aged; Brain Edema; Critical Care; Electrodes, Implanted; Extracellular Space; Female; Frontal Lobe; Glutamic Acid; Glycerol; Humans; Infarction, Middle Cerebral Artery; Intracranial Hypertension; Intracranial Pressure; Lactic Acid; Male; Microdialysis; Middle Aged; Monitoring, Physiologic; Predictive Value of Tests; Prognosis; Prospective Studies; Pyruvic Acid; Risk Assessment | 2001 |
Effects of hypothermia on excitatory amino acids and metabolism in stroke patients: a microdialysis study.
Topics: Adult; Aged; Brain; Female; Glutamic Acid; Glycerol; Humans; Hypothermia, Induced; Infarction, Middle Cerebral Artery; Intracranial Pressure; Lactic Acid; Male; Microdialysis; Middle Aged; Predictive Value of Tests; Prospective Studies; Pyruvic Acid; Regression Analysis; Survival Rate; Tomography, X-Ray Computed | 2002 |
160 other study(ies) available for glutamic acid and Infarction, Middle Cerebral Artery
| Article | Year |
|---|---|
Arbutin protects brain against middle cerebral artery occlusion-reperfusion (MCAo/R) injury.
Topics: Animals; Arbutin; Blood-Brain Barrier; Brain; Chromatography, High Pressure Liquid; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Infarction, Middle Cerebral Artery; Male; Maze Learning; Memory, Short-Term; Mice; Neuroprotective Agents; Neurotransmitter Agents; Permeability; Reperfusion Injury | 2021 |
A Novel Phenylpyrrolidine Derivative: Synthesis and Effect on Cognitive Functions in Rats with Experimental Ishemic Stroke.
Topics: Animals; Behavior, Animal; Brain Ischemia; Cognition; Disease Models, Animal; Glutamic Acid; Infarction, Middle Cerebral Artery; Ischemic Stroke; Male; Molecular Docking Simulation; Neurons; Neuroprotective Agents; Primary Cell Culture; Pyrrolidines; Rats; Rats, Wistar; Stroke | 2021 |
Calcitriol Pretreatment Attenuates Glutamate Neurotoxicity by Regulating NMDAR and CYP46A1 Gene Expression in Rats Subjected to Transient Middle Cerebral Artery Occlusion.
Topics: Animals; Brain Ischemia; Calcitriol; Cholesterol 24-Hydroxylase; Disease Models, Animal; Gene Expression; Glutamic Acid; Infarction, Middle Cerebral Artery; Ischemia; Male; Neuroprotective Agents; Neurotoxicity Syndromes; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Reperfusion Injury; Stroke | 2022 |
SAM, a cystathionine beta-synthase activator, promotes hydrogen sulfide to promote neural repair resulting from massive cerebral infarction induced by middle cerebral artery occlusion.
Topics: Animals; Apoptosis; Brain Ischemia; Cystathionine beta-Synthase; Glucose; Glutamic Acid; Humans; Hydrogen Sulfide; Infarction, Middle Cerebral Artery; Oxygen; PC12 Cells; Rats; Reperfusion Injury | 2022 |
A multiomics and network pharmacological study reveals the neuroprotective efficacy of Fu-Fang-Dan-Zhi tablets against glutamate-induced oxidative cell death.
Topics: Animals; Cell Death; Drugs, Chinese Herbal; Glutamic Acid; Infarction, Middle Cerebral Artery; Ischemic Stroke; Molecular Docking Simulation; Neuroprotection; Oxidative Stress; Rats; Reactive Oxygen Species; Tablets | 2022 |
Retinoic Acid Prevents the Neuronal Damage Through the Regulation of Parvalbumin in an Ischemic Stroke Model.
Topics: Animals; Apoptosis; Brain Ischemia; Calcium; Glutamic Acid; Infarction, Middle Cerebral Artery; Ischemic Stroke; Neurons; Neuroprotective Agents; Parvalbumins; Rats; Rats, Sprague-Dawley; Tretinoin | 2023 |
Retinoic Acid Has Neuroprotective effects by Modulating Thioredoxin in Ischemic Brain Damage and Glutamate-exposed Neurons.
Topics: Animals; Apoptosis; Brain; Brain Ischemia; Caspase 3; Glutamic Acid; Infarction, Middle Cerebral Artery; Male; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Thioredoxins; Tretinoin | 2023 |
Astrocytic AEG-1 regulates expression of TREK-1 under acute hypoxia.
Topics: Animals; Apoptosis; Astrocytes; Cell Hypoxia; Electroporation; Glutamic Acid; HEK293 Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Infarction, Middle Cerebral Artery; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Neurons; Potassium Channels, Tandem Pore Domain; RNA-Binding Proteins; RNA, Messenger | 2020 |
Quercetin Attenuates Decrease of Thioredoxin Expression Following Focal Cerebral Ischemia and Glutamate-induced Neuronal Cell Damage.
Topics: Animals; Brain Edema; Brain Ischemia; Cell Death; Disease Models, Animal; Glutamic Acid; Hippocampus; Infarction, Middle Cerebral Artery; Male; Neuroprotective Agents; Quercetin; Rats; Rats, Sprague-Dawley; Thioredoxins | 2020 |
Downregulation of Microrna-421 Relieves Cerebral Ischemia/Reperfusion Injuries: Involvement of Anti-apoptotic and Antioxidant Activities.
Topics: Animals; Antagomirs; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; Brain Ischemia; Cerebral Infarction; Down-Regulation; Drug Evaluation, Preclinical; Glutamic Acid; Infarction, Middle Cerebral Artery; Lipid Peroxidation; Male; Malondialdehyde; Myeloid Cell Leukemia Sequence 1 Protein; Neuroprotective Agents; Oxidative Stress; PC12 Cells; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2020 |
LRRC8A-dependent volume-regulated anion channels contribute to ischemia-induced brain injury and glutamatergic input to hippocampal neurons.
Topics: Animals; Behavior, Animal; CA1 Region, Hippocampal; Excitatory Postsynaptic Potentials; Glucose; Glutamic Acid; Hippocampus; Hypoxia; Infarction, Middle Cerebral Artery; Ion Channels; Ischemic Stroke; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Nestin; Neurons; Patch-Clamp Techniques | 2020 |
Dapsone prolong delayed excitotoxic neuronal cell death by interacting with proapoptotic/survival signaling proteins.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Brain; Cells, Cultured; Dapsone; Disease Models, Animal; Glutamic Acid; Infarction, Middle Cerebral Artery; Male; Neurons; Neuroprotective Agents; Rats, Wistar; Reperfusion Injury; Signal Transduction | 2020 |
Calpain-mediated cleavage of Fbxw7 during excitotoxicity.
Topics: Animals; Calpain; Cell Death; Cerebral Cortex; Cyclin-Dependent Kinase 5; F-Box-WD Repeat-Containing Protein 7; Glutamic Acid; Infarction, Middle Cerebral Artery; Neurons; Rats | 2020 |
Identification of regulated proteins by resveratrol in glutamate-induced cortical injury of newborn rats.
Topics: Animals; Animals, Newborn; Glutamic Acid; Infarction, Middle Cerebral Artery; Rats; Rats, Sprague-Dawley; Resveratrol; Rodent Diseases; Stilbenes | 2021 |
Capsaicin protects cortical neurons against ischemia/reperfusion injury via down-regulating NMDA receptors.
Topics: Animals; Behavior, Animal; Capsaicin; Cells, Cultured; Down-Regulation; Excitatory Amino Acids; Glutamic Acid; Infarction, Middle Cerebral Artery; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reperfusion Injury; TRPV Cation Channels | 2017 |
Assessment of the Neuroprotective Effects of Arginine-Rich Protamine Peptides, Poly-Arginine Peptides (R12-Cyclic, R22) and Arginine-Tryptophan-Containing Peptides Following In Vitro Excitotoxicity and/or Permanent Middle Cerebral Artery Occlusion in Rats
Topics: Amino Acids; Animals; Arginine; Astrocytes; Calcium Signaling; Cells, Cultured; Cerebral Cortex; Drug Evaluation, Preclinical; Glutamic Acid; In Vitro Techniques; Infarction, Middle Cerebral Artery; Male; Neurons; Neuroprotective Agents; Oligopeptides; Peptides, Cyclic; Protamines; Rats; Rats, Sprague-Dawley; Tryptophan | 2017 |
Ceftriaxone- and N-acetylcysteine-induced brain tolerance to ischemia: Influence on glutamate levels in focal cerebral ischemia.
Topics: Acetylcysteine; Amino Acid Transport Systems, Acidic; Animals; Astrocytes; Brain Ischemia; Ceftriaxone; Excitatory Amino Acid Transporter 2; Frontal Lobe; Gene Expression Regulation; Glutamic Acid; Hippocampus; Humans; Infarction, Middle Cerebral Artery; Rats; Synaptic Transmission | 2017 |
Ischemia-induced Neuronal Cell Death Is Mediated by Chemokine Receptor CX3CR1.
Topics: Animals; Apoptosis; Calcium; Cells, Cultured; Corpus Striatum; CX3C Chemokine Receptor 1; Glutamic Acid; Hippocampus; Infarction, Middle Cerebral Artery; Male; Mice; Mice, Inbred C57BL; Neurons; Up-Regulation | 2018 |
Metabolomics-based mechanisms exploration of Huang-Lian Jie-Du decoction on cerebral ischemia via UPLC-Q-TOF/MS analysis on rat serum.
Topics: Acetylcholine; Animals; Behavior, Animal; Biomarkers; Brain; Chromatography, Liquid; Disease Models, Animal; Drugs, Chinese Herbal; Energy Metabolism; Glutamic Acid; Infarction, Middle Cerebral Artery; Inflammation Mediators; Least-Squares Analysis; Male; Metabolomics; Multivariate Analysis; Neuroprotective Agents; Principal Component Analysis; Rats, Sprague-Dawley; Spectrometry, Mass, Electrospray Ionization; Stress, Physiological; Time Factors | 2018 |
Neuroprotective Effect and Mechanism of Action of Tetramethylpyrazine Nitrone for Ischemic Stroke Therapy.
Topics: Animals; Apoptosis Regulatory Proteins; Calcium; Cell Hypoxia; Cells, Cultured; Drug Evaluation, Preclinical; Free Radical Scavengers; Glucose; Glutamic Acid; Infarction, Middle Cerebral Artery; Lipid Peroxidation; Mitochondria; Motor Activity; Nerve Tissue Proteins; Neuroprotective Agents; Nitrogen Oxides; Patch-Clamp Techniques; Protein Kinase Inhibitors; Pyrazines; Rats; Rats, Sprague-Dawley; Signal Transduction | 2018 |
Neuroprotective effects of midazolam on focal cerebral ischemia in rats through anti‑apoptotic mechanisms.
Topics: Animals; Apoptosis; Brain; Brain Ischemia; Gene Expression Regulation; Glutamic Acid; Infarction, Middle Cerebral Artery; L-Lactate Dehydrogenase; Male; Midazolam; Neurons; Neuroprotection; Neuroprotective Agents; Rats, Sprague-Dawley | 2019 |
Astragaloside IV reduces neuronal apoptosis and parthanatos in ischemic injury by preserving mitochondrial hexokinase-II.
Topics: Animals; Apoptosis Inducing Factor; Astragalus propinquus; Female; Gene Expression Regulation; Glutamic Acid; Hexokinase; Humans; Hypoxia-Ischemia, Brain; Infarction, Middle Cerebral Artery; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C57BL; Mitochondria; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Neurons; Neuroprotective Agents; Oxygen Consumption; Parthanatos; Primary Cell Culture; Protein Binding; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Saponins; Triterpenes | 2019 |
Stroke Accelerates and Uncouples Intrinsic and Synaptic Excitability Maturation of Mouse Hippocampal DCX
Topics: Animals; Dentate Gyrus; Doublecortin Domain Proteins; Doublecortin Protein; Female; Glutamic Acid; Infarction, Middle Cerebral Artery; Male; Mice; Microtubule-Associated Proteins; Neurogenesis; Neurons; Neuropeptides; Synaptic Potentials | 2019 |
Quercetin alleviates the injury-induced decrease of protein phosphatase 2A subunit B in cerebral ischemic animal model and glutamate-exposed HT22 cells.
Topics: Animals; Brain Ischemia; Cell Line, Transformed; Disease Models, Animal; Glutamic Acid; Infarction, Middle Cerebral Artery; Male; Mice; Neuroprotective Agents; Protein Phosphatase 2; Quercetin; Rats, Sprague-Dawley | 2019 |
The effect of pyruvate on the development and progression of post-stroke depression: A new therapeutic approach.
Topics: Animals; Depression; Glutamic Acid; Infarction, Middle Cerebral Artery; Male; Pyruvic Acid; Random Allocation; Rats; Rats, Sprague-Dawley; Stroke | 2019 |
Temporal effect of acupuncture on amino acid neurotransmitters in rats with acute cerebral ischaemia.
Topics: Acupuncture Therapy; Animals; Brain Ischemia; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Humans; Infarction, Middle Cerebral Artery; Male; Neurotransmitter Agents; Rats; Rats, Sprague-Dawley | 2019 |
Delayed post-conditioning reduces post-ischemic glutamate level and improves protein synthesis in brain.
Topics: Animals; Brain Chemistry; Brain Ischemia; CA1 Region, Hippocampal; Cerebral Cortex; Dentate Gyrus; Glutamic Acid; Hippocampus; Infarction, Middle Cerebral Artery; Ischemic Attack, Transient; Ischemic Postconditioning; Male; Protein Biosynthesis; Rats; Rats, Wistar; Reperfusion | 2013 |
Effects of medullary administration of a nitric oxide precursor on cardiovascular responses and neurotransmission during static exercise following ischemic stroke.
Topics: Animals; Arginine; Cardiovascular System; Female; gamma-Aminobutyric Acid; Glutamic Acid; Infarction, Middle Cerebral Artery; Microdialysis; Muscle Contraction; Muscle, Skeletal; Nitric Oxide; omega-N-Methylarginine; Physical Conditioning, Animal; Rats; Rats, Sprague-Dawley; Reperfusion; Stroke; Synaptic Transmission | 2013 |
Neurodegeneration after transient brain ischemia in aged mice: beneficial effects of bilobalide.
Topics: Adenosine Triphosphate; Aging; Animals; Brain Infarction; Cyclopentanes; Disease Models, Animal; Extracellular Fluid; Female; Furans; Ginkgolides; Glucose; Glutamic Acid; Infarction, Middle Cerebral Artery; Locomotion; Mice; Microdialysis; Mitochondria; Multienzyme Complexes; Neurodegenerative Diseases; Neuroprotective Agents; Oxidative Phosphorylation | 2013 |
Neuroprotection by bilobalide in ischemia: improvement of mitochondrial function.
Topics: Animals; Brain Ischemia; Cyclopentanes; Female; Furans; Ginkgolides; Glucose; Glutamic Acid; Infarction, Middle Cerebral Artery; Mice; Microdialysis; Mitochondria; Neostriatum; Neuroprotective Agents; Oxygen Consumption; Permeability | 2013 |
Plasma levels of neuron specific enolase quantify the extent of neuronal injury in murine models of ischemic stroke and multiple sclerosis.
Topics: Amyloid beta-Protein Precursor; Animals; Brain; Brain Infarction; Cells, Cultured; Disease Models, Animal; Embryo, Mammalian; Glutamic Acid; Infarction, Middle Cerebral Artery; L-Lactate Dehydrogenase; Magnetic Resonance Imaging; Mice; Mice, Inbred C57BL; Microtubule-Associated Proteins; Multiple Sclerosis; Myelin-Oligodendrocyte Glycoprotein; Neurons; Peptide Fragments; Phosphopyruvate Hydratase; Time Factors | 2013 |
NOX2 deficiency ameliorates cerebral injury through reduction of complexin II-mediated glutamate excitotoxicity in experimental stroke.
Topics: Adaptor Proteins, Vesicular Transport; Animals; Astrocytes; Cells, Cultured; Glutamic Acid; Hippocampus; Infarction, Middle Cerebral Artery; Male; Membrane Glycoproteins; Mice, Knockout; NADPH Oxidase 2; NADPH Oxidases; Necrosis; Nerve Tissue Proteins; Oxidative Stress; Reactive Oxygen Species | 2013 |
Amelioration of ischemic brain damage by peritoneal dialysis.
Topics: Animals; Cerebral Cortex; Corpus Callosum; Electric Stimulation; Glutamic Acid; Humans; Infarction, Middle Cerebral Artery; Magnetic Resonance Imaging; Male; Peritoneal Dialysis; Rats; Rats, Sprague-Dawley; Recovery of Function; Renal Insufficiency, Chronic; Stroke | 2013 |
ERK inhibition with PD184161 mitigates brain damage in a mouse model of stroke.
Topics: Aniline Compounds; Animals; Benzamides; Brain; Cell Death; Cells, Cultured; Disease Models, Animal; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Gene Expression; Glutamic Acid; Infarction, Middle Cerebral Artery; Male; Mice, Inbred C57BL; Neurons; Stroke | 2014 |
Daphnetin, a natural coumarin derivative, provides the neuroprotection against glutamate-induced toxicity in HT22 cells and ischemic brain injury.
Topics: Animals; Animals, Newborn; Brain Ischemia; Cell Death; Cell Line; Disease Models, Animal; Glutamic Acid; Glutathione; Hippocampus; Infarction, Middle Cerebral Artery; Male; Mice; Mice, Inbred ICR; Neuroprotective Agents; Rats; Superoxide Dismutase; Umbelliferones | 2014 |
Severity of middle cerebral artery occlusion determines retinal deficits in rats.
Topics: Animals; Brain Ischemia; Electroretinography; Extracellular Space; Eye; Glial Fibrillary Acidic Protein; Glutamate-Ammonia Ligase; Glutamic Acid; Infarction, Middle Cerebral Artery; Male; Rats; Rats, Sprague-Dawley; Retinal Diseases; Severity of Illness Index; Signal Transduction | 2014 |
Characterization of Gcf2/Lrrfip1 in experimental cerebral ischemia and its role as a modulator of Akt, mTOR and β-catenin signaling pathways.
Topics: Animals; Astrocytes; beta Catenin; Brain; Brain Ischemia; Cells, Cultured; Cytoplasm; Excitatory Amino Acid Transporter 2; Gene Knockdown Techniques; Glutamic Acid; Infarction, Middle Cerebral Artery; Male; Neurons; Proto-Oncogene Proteins c-akt; Rats, Inbred F344; Rats, Wistar; RNA Isoforms; RNA-Binding Proteins; Signal Transduction; TOR Serine-Threonine Kinases; Up-Regulation | 2014 |
Disruption of the nuclear p53-GAPDH complex protects against ischemia-induced neuronal damage.
Topics: Animals; Brain Ischemia; Cell Death; Cell Nucleus; Cytoprotection; Disease Models, Animal; Glutamic Acid; Glyceraldehyde-3-Phosphate Dehydrogenases; HEK293 Cells; Humans; Infarction, Middle Cerebral Artery; Kainic Acid; Neurons; Neuroprotective Agents; Nuclear Proteins; Protein Binding; Protein Transport; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Recombinant Fusion Proteins; Tumor Suppressor Protein p53; Ubiquitin-Protein Ligases | 2014 |
Estradiol ameliorates the reduction in parvalbumin expression induced by ischemic brain injury.
Topics: Animals; Calcium; Cell Death; Cell Line; Estradiol; Female; Glutamic Acid; Hippocampus; Infarction, Middle Cerebral Artery; Ischemic Attack, Transient; Mice; Neurons; Neuroprotective Agents; Ovariectomy; Parvalbumins; Rats, Sprague-Dawley | 2014 |
The major cholesterol metabolite cholestane-3β,5α,6β-triol functions as an endogenous neuroprotectant.
Topics: Adult; Animals; Brain Injuries; Cells, Cultured; Central Nervous System; Cholestanols; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Humans; Infarction, Middle Cerebral Artery; Male; Neurons; Neuroprotective Agents; Protein Binding; Rabbits; Rats; Rats, Sprague-Dawley; Spinal Cord Ischemia; Time Factors; Tissue Distribution; Young Adult | 2014 |
Effect of ligustrazine on levels of amino acid neurotransmitters in rat striatum after cerebral ischemia-reperfusion injury.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Brain Ischemia; Corpus Striatum; gamma-Aminobutyric Acid; Glutamic Acid; Infarction, Middle Cerebral Artery; Male; Microdialysis; Molecular Structure; Neurotransmitter Agents; Pyrazines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Taurine; Time Factors | 2014 |
Estradiol alleviates the ischemic brain injury-induced decrease of neuronal calcium sensor protein hippocalcin.
Topics: Animals; Apoptosis; Brain Ischemia; Calcium; Cells, Cultured; Cerebral Cortex; Estradiol; Female; Glutamic Acid; Hippocalcin; Hippocampus; Infarction, Middle Cerebral Artery; Mice; Necrosis; Neurons; Proteome; Rats, Sprague-Dawley | 2014 |
The neuroprotective properties of the superoxide dismutase mimetic tempol correlate with its ability to reduce pathological glutamate release in a rodent model of stroke.
Topics: Alanine; Animals; Antipyrine; Astrocytes; Brain; Cells, Cultured; Cyclic N-Oxides; Drug Evaluation, Preclinical; Edaravone; Free Radical Scavengers; Glutamic Acid; Infarction, Middle Cerebral Artery; Male; Molecular Mimicry; Neuroprotective Agents; Oxidative Stress; Rats, Sprague-Dawley; Spin Labels; Superoxides; Synaptosomes; Taurine | 2014 |
Alleviation of glutamate mediated neuronal insult by piroxicam in rodent model of focal cerebral ischemia: a possible mechanism of GABA agonism.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Catalase; Cells, Cultured; Cerebral Cortex; Drug Evaluation, Preclinical; GABA Agonists; gamma-Aminobutyric Acid; Glutamic Acid; Infarction, Middle Cerebral Artery; Male; Neuroprotective Agents; Piroxicam; Rats; Superoxide Dismutase; Superoxides | 2014 |
Characterization of a Synthetic Steroid 24-keto-cholest-5-en-3β, 19-diol as a Neuroprotectant.
Topics: Animals; Animals, Newborn; Calcium; Cell Hypoxia; Cells, Cultured; Cerebellum; Cholestanols; Disease Models, Animal; Excitatory Amino Acid Agonists; Glutamic Acid; Infarction, Middle Cerebral Artery; L-Lactate Dehydrogenase; N-Methylaspartate; Neurons; Neuroprotective Agents; Oxygen; Rats; Rats, Sprague-Dawley | 2015 |
Protection of erythropoietin against ischemic neurovascular unit injuries through the effects of connexin43.
Topics: Animals; Calcium; Cell Communication; Connexin 43; Erythropoietin; Gap Junctions; Gene Expression; Glutamic Acid; Infarction, Middle Cerebral Artery; Male; Neurons; Neuroprotective Agents; Rats, Sprague-Dawley; RNA Interference; RNA, Small Interfering | 2015 |
Involvement of the paraventricular nucleus in the occurrence of arrhythmias in middle cerebral artery occlusion rats.
Topics: Animals; Arrhythmias, Cardiac; Disease Models, Animal; Dizocilpine Maleate; Electrocardiography; Gene Expression Regulation; Glutamic Acid; Heart Rate; Infarction, Middle Cerebral Artery; Injections, Intraventricular; Male; Nervous System Diseases; Neuroprotective Agents; Paraventricular Hypothalamic Nucleus; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Time Factors | 2015 |
Curcumin attenuates glutamate neurotoxicity in the hippocampus by suppression of ER stress-associated TXNIP/NLRP3 inflammasome activation in a manner dependent on AMPK.
Topics: AMP-Activated Protein Kinases; Animals; Behavior, Animal; Carrier Proteins; Cell Line, Tumor; Curcumin; Endoplasmic Reticulum Stress; Glutamic Acid; Hippocampus; Humans; Infarction, Middle Cerebral Artery; Inflammasomes; Interleukin-1beta; Interleukin-6; Male; Membrane Potential, Mitochondrial; Mice, Inbred ICR; Motor Activity; Neuroprotective Agents; NLR Family, Pyrin Domain-Containing 3 Protein; Rats, Sprague-Dawley; Reactive Oxygen Species; Taurochenodeoxycholic Acid; Thioredoxins | 2015 |
Spreading depolarizations mediate excitotoxicity in the development of acute cortical lesions.
Topics: Analysis of Variance; Animals; Aspartic Acid; Blood Gas Analysis; Blood Pressure; Brain Injuries; Cerebral Cortex; Cortical Spreading Depression; Disease Models, Animal; Electrophysiology; Excitatory Amino Acid Agents; Female; Glutamic Acid; Humans; Infarction, Middle Cerebral Artery; Male; Microelectrodes; Rats; Rats, Sprague-Dawley | 2015 |
Hydrogen-rich water protects against ischemic brain injury in rats by regulating calcium buffering proteins.
Topics: Animals; Brain Ischemia; Calcium; Glutamic Acid; Hippocalcin; Hydrogen; Infarction, Middle Cerebral Artery; Male; Neuroprotective Agents; Parvalbumins; Rats; Rats, Sprague-Dawley; Water | 2015 |
Scheme of Ischaemia-triggered Agents during Brain Infarct Evolution in a Rat Model of Permanent Focal Ischaemia.
Topics: Animals; Apoptosis Regulatory Proteins; Blood-Brain Barrier; Capillary Permeability; Glutamic Acid; Infarction, Middle Cerebral Artery; Male; Rats; Rats, Wistar | 2015 |
Reduced severity of ischemic stroke and improvement of mitochondrial function after dietary treatment with the anaplerotic substance triheptanoin.
Topics: Adenosine Triphosphate; Animals; Body Weight; Brain; Brain Ischemia; Disease Models, Animal; Electron Transport; Fatty Acids; Female; Glucose; Glutamic Acid; Infarction, Middle Cerebral Artery; Matrix Metalloproteinases; Mice; Mitochondria; Motor Activity; Oxygen Consumption; Severity of Illness Index; Stroke; Triglycerides | 2015 |
L-NAME combats excitotoxicity and recuperates neurological deficits in MCAO/R rats.
Topics: Adenosine Triphosphate; Animals; Cerebral Infarction; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glutamate-Ammonia Ligase; Glutamic Acid; Infarction, Middle Cerebral Artery; Interleukin-10; Male; NAD; Nervous System Diseases; NG-Nitroarginine Methyl Ester; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha | 2015 |
Inhibition of p53 attenuates ischemic stress-induced activation of astrocytes.
Topics: Animals; Astrocytes; Benzothiazoles; Brain Ischemia; Cell Hypoxia; Cells, Cultured; Central Nervous System Agents; Glucose; Glutamic Acid; Infarction, Middle Cerebral Artery; Male; Neurons; Rats, Sprague-Dawley; RNA Interference; Stress, Physiological; Toluene; Tumor Suppressor Protein p53 | 2015 |
Effects of Chronic Alcohol Exposure on the Modulation of Ischemia-Induced Glutamate Release via Cannabinoid Receptors in the Dorsal Hippocampus.
Topics: Animals; Arachidonic Acids; Cannabinoids; Dose-Response Relationship, Drug; Ethanol; Glutamic Acid; Hippocampus; Indoles; Infarction, Middle Cerebral Artery; Ischemia; Male; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant | 2015 |
Pertussis toxin reduces calcium influx to protect ischemic stroke in a middle cerebral artery occlusion model.
Topics: Animals; Apoptosis; Brain; Brain Infarction; Calcium; Caspase 3; Cells, Cultured; Cerebral Cortex; Cerebrovascular Circulation; Disease Models, Animal; Glutamic Acid; Infarction, Middle Cerebral Artery; L-Lactate Dehydrogenase; Magnetic Resonance Imaging; Male; Mice; Mice, Inbred C57BL; Neurons; Pertussis Toxin; Stroke | 2015 |
Beneficial effect of magnesium lithospermate B on cerebral ischemia-reperfusion injury in rats involves the regulation of miR-107/glutamate transporter 1 pathway.
Topics: Animals; Apoptosis; Brain; Cell Line; Drugs, Chinese Herbal; Excitatory Amino Acid Transporter 2; Glutamic Acid; Hypoxia; Infarction, Middle Cerebral Artery; Male; MicroRNAs; Neurons; Neuroprotective Agents; Rats, Sprague-Dawley; Reperfusion Injury | 2015 |
Totarol prevents neuronal injury in vitro and ameliorates brain ischemic stroke: Potential roles of Akt activation and HO-1 induction.
Topics: Abietanes; Animals; Antioxidants; Brain; Cell Death; Cell Hypoxia; Cells, Cultured; Disease Models, Animal; Diterpenes; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Induction; Excitatory Amino Acid Agonists; Glucose; Glutamic Acid; Glutathione; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Heme Oxygenase (Decyclizing); Infarction, Middle Cerebral Artery; Male; Neurons; Neuroprotective Agents; NF-E2-Related Factor 2; Oxidative Stress; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats, Sprague-Dawley; Signal Transduction; Superoxide Dismutase; Time Factors | 2015 |
Naturally occurring marine steroid 24-methylenecholestane-3β,5α,6β,19-tetraol functions as a novel neuroprotectant.
Topics: Animals; Aquatic Organisms; Brain Ischemia; Cerebral Cortex; Cholestanols; Glutamic Acid; Infarction, Middle Cerebral Artery; Magnetic Resonance Spectroscopy; Male; Mice; N-Methylaspartate; Neurons; Neuroprotective Agents; Rats, Sprague-Dawley | 2016 |
An Antagomir to MicroRNA-106b-5p Ameliorates Cerebral Ischemia and Reperfusion Injury in Rats Via Inhibiting Apoptosis and Oxidative Stress.
Topics: Animals; Antagomirs; Antioxidants; Apoptosis; Base Sequence; bcl-2-Associated X Protein; Brain Ischemia; Cerebral Cortex; Down-Regulation; Gene Expression Regulation; Glutamic Acid; Infarction, Middle Cerebral Artery; Male; Malondialdehyde; MicroRNAs; Myeloid Cell Leukemia Sequence 1 Protein; Oxidative Stress; PC12 Cells; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Superoxide Dismutase; Up-Regulation | 2017 |
Dual targeted nanocarrier for brain ischemic stroke treatment.
Topics: Animals; Apoptosis; Brain; Cell Line; Cell Line, Tumor; Collagen Type IV; Drug Liberation; Glutamic Acid; Infarction, Middle Cerebral Artery; Liposomes; Male; Mice, Inbred ICR; Nanoparticles; Neurons; Neuroprotective Agents; Peptide Fragments; Polyethylene Glycols; Rats, Sprague-Dawley; Stroke | 2016 |
Treatment of dysphasia with rTMS and language therapy after childhood stroke: Multimodal imaging of plastic change.
Topics: Adolescent; Aphasia, Broca; Brain Mapping; Broca Area; Functional Laterality; Glutamic Acid; Humans; Infarction, Middle Cerebral Artery; Inositol; Language Therapy; Magnetic Resonance Imaging; Male; Multimodal Imaging; Neuronal Plasticity; Neurons; Quality of Life; Rest; Speech Therapy; Stroke; Transcranial Magnetic Stimulation; White Matter | 2016 |
Neurotrophic and neuroprotective effects of oxyntomodulin in neuronal cells and a rat model of stroke.
Topics: Animals; Brain Infarction; Cell Line, Tumor; Cell Proliferation; CREB-Binding Protein; Cyclic AMP; Disease Models, Animal; Enzyme Inhibitors; Glutamic Acid; Humans; Hydrogen Peroxide; Infarction, Middle Cerebral Artery; Locomotion; Male; Nerve Growth Factors; Neurons; Neuroprotective Agents; Oxyntomodulin; Rats; Rats, Sprague-Dawley; Signal Transduction; Stroke | 2017 |
Phaseic Acid, an Endogenous and Reversible Inhibitor of Glutamate Receptors in Mouse Brain.
Topics: Animals; Brain; Brain Ischemia; Cells, Cultured; Glutamic Acid; Infarction, Middle Cerebral Artery; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Sesquiterpenes | 2016 |
Glutamate oxaloacetate transaminase enables anaplerotic refilling of TCA cycle intermediates in stroke-affected brain.
Topics: Animals; Aspartate Aminotransferases; Cells, Cultured; Citric Acid Cycle; Glucose; Glutamic Acid; Infarction, Middle Cerebral Artery; Male; Mice; Mice, Inbred C57BL; Oxygen; Rats; Rats, Sprague-Dawley | 2017 |
Ginkgo biloba extract neuroprotective action is dependent on heme oxygenase 1 in ischemic reperfusion brain injury.
Topics: Animals; Antioxidants; Brain Damage, Chronic; Brain Ischemia; Cells, Cultured; Cerebrovascular Circulation; Cyclopentanes; Drug Evaluation, Preclinical; Enzyme Induction; Excitatory Amino Acid Antagonists; Furans; Ginkgo biloba; Ginkgolides; Glutamic Acid; Heme Oxygenase-1; Infarction, Middle Cerebral Artery; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Plant Extracts; Reperfusion Injury; Response Elements | 2008 |
Neuroprotection and enhanced neurogenesis by extract from the tropical plant Knema laurina after inflammatory damage in living brain tissue.
Topics: Analysis of Variance; Animals; Animals, Newborn; Bromodeoxyuridine; Cell Line, Transformed; Cell Survival; Disease Models, Animal; Dose-Response Relationship, Drug; Doublecortin Domain Proteins; Encephalitis; Glucose; Glutamic Acid; Hippocampus; Hypoxia; Infarction, Middle Cerebral Artery; Lipopolysaccharides; MAP Kinase Kinase Kinases; Mice; Microglia; Microtubule-Associated Proteins; Myristicaceae; Neurogenesis; Neuropeptides; Neuroprotective Agents; Organ Culture Techniques; Phytotherapy; Plant Extracts | 2009 |
Evolution of the neurochemical profile after transient focal cerebral ischemia in the mouse brain.
Topics: Animals; Aspartic Acid; Cerebrovascular Circulation; Corpus Striatum; Glucose; Glutamic Acid; Glutamine; Infarction, Middle Cerebral Artery; Ischemic Attack, Transient; Kinetics; Lactic Acid; Magnetic Resonance Spectroscopy; Metabolism; Mice | 2009 |
Pre-ischemic treadmill training affects glutamate and gamma aminobutyric acid levels in the striatal dialysate of a rat model of cerebral ischemia.
Topics: Animals; Brain Ischemia; Corpus Striatum; Disease Models, Animal; Exercise Test; gamma-Aminobutyric Acid; Glutamic Acid; Infarction, Middle Cerebral Artery; Ischemic Preconditioning; Male; Microdialysis; Physical Conditioning, Animal; Rats; Rats, Sprague-Dawley | 2009 |
Evidence for neuroprotection by the fenamate NSAID, mefenamic acid.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain Edema; Cell Death; Glutamic Acid; Hippocampus; Infarction, Middle Cerebral Artery; Ischemic Attack, Transient; Male; Mefenamic Acid; Neurons; Neuroprotective Agents; Rats; Rats, Wistar; Stroke | 2009 |
GIF-0173 protects against cerebral infarction through DP1 receptor activation.
Topics: Animals; Brain Infarction; Calcium; Cell Death; Cells, Cultured; Cerebral Cortex; Cerebrovascular Circulation; Dantrolene; Disease Models, Animal; Dose-Response Relationship, Drug; Glutamic Acid; Hydantoins; Infarction, Middle Cerebral Artery; Intracellular Fluid; Lactones; Laser-Doppler Flowmetry; Male; N-Methylaspartate; Neurons; Neuroprotective Agents; Platelet Aggregation Inhibitors; Prostaglandin D2; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Immunologic; Receptors, Prostaglandin; Sesquiterpenes; Severity of Illness Index; Tetrazolium Salts | 2009 |
Prevention of Glutamate Accumulation and Upregulation of Phospho-Akt may Account for Neuroprotection Afforded by Bergamot Essential Oil against Brain Injury Induced by Focal Cerebral Ischemia in Rat.
Topics: Animals; Brain Infarction; Brain Ischemia; Glutamic Acid; Infarction, Middle Cerebral Artery; Male; Neuroprotective Agents; Oils, Volatile; Plant Oils; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Up-Regulation | 2009 |
Nitroxyl exacerbates ischemic cerebral injury and oxidative neurotoxicity.
Topics: Animals; Blood Pressure; Brain Infarction; Cells, Cultured; Dinoprost; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Enzyme-Linked Immunosorbent Assay; F2-Isoprostanes; Gas Chromatography-Mass Spectrometry; Glutamic Acid; Infarction, Middle Cerebral Artery; L-Lactate Dehydrogenase; Mice; Mice, Inbred C57BL; Neuroglia; Neurons; Neuroprotective Agents; Nitrites; Nitrogen Oxides; Oxidative Stress; Statistics, Nonparametric; Tetrazolium Salts; Thiazoles; Time Factors | 2009 |
Effects of treadmill training on motor performance and extracellular glutamate level in striatum in rats with or without transient middle cerebral artery occlusion.
Topics: Animals; Brain Ischemia; Brain-Derived Neurotrophic Factor; Corpus Striatum; Extracellular Space; Glutamic Acid; Infarction, Middle Cerebral Artery; Male; Motor Activity; Physical Conditioning, Animal; Random Allocation; Rats; Rats, Sprague-Dawley; Synapsins; Task Performance and Analysis | 2009 |
CaMKII phosphorylates collapsin response mediator protein 2 and modulates axonal damage during glutamate excitotoxicity.
Topics: Animals; Axons; Brain; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Death; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Dizocilpine Maleate; Embryo, Mammalian; Enzyme Activation; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glutamic Acid; Green Fluorescent Proteins; Infarction, Middle Cerebral Artery; Intercellular Signaling Peptides and Proteins; Mice; Mice, Inbred C57BL; Mutation; Nerve Tissue Proteins; Neurons; Phosphorylation; Semaphorin-3A; Signal Transduction; Transfection; Tubulin | 2009 |
Neuroprotective effects of resveratrol on ischemic injury mediated by modulating the release of neurotransmitter and neuromodulator in rats.
Topics: Animals; Antioxidants; Brain; Brain Infarction; Disease Models, Animal; Ethanolamines; Excitatory Postsynaptic Potentials; Extracellular Fluid; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Hypothalamus; Hypoxia-Ischemia, Brain; Infarction, Middle Cerebral Artery; Inhibitory Postsynaptic Potentials; Male; Neuroprotective Agents; Neurotransmitter Agents; Rats; Rats, Sprague-Dawley; Resveratrol; Stilbenes; Treatment Outcome | 2010 |
Carnosine protects against permanent cerebral ischemia in histidine decarboxylase knockout mice by reducing glutamate excitotoxicity.
Topics: Amino Acid Transport System X-AG; Animals; Apoptosis; Astrocytes; Carnosine; Glutamic Acid; Histidine Decarboxylase; Infarction, Middle Cerebral Artery; Male; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; N-Methylaspartate; Neuroprotective Agents; PC12 Cells; Rats; Reactive Oxygen Species; Rotenone | 2010 |
Neuroprotective effect of L-serine against temporary cerebral ischemia in rats.
Topics: Animals; Brain; Brain Ischemia; Cell Hypoxia; Cells, Cultured; Dose-Response Relationship, Drug; Glutamic Acid; Glycine Agents; Hippocampus; Infarction, Middle Cerebral Artery; Male; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Serine; Strychnine; Time Factors | 2010 |
Prolonged activation of ERK triggers glutamate-induced apoptosis of astrocytes: neuroprotective effect of FK506.
Topics: Amino Acid Transport System X-AG; Animals; Animals, Newborn; Apoptosis; Astrocytes; Butadienes; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Glutamic Acid; Hypoxia-Ischemia, Brain; Immunosuppressive Agents; Infarction, Middle Cerebral Artery; Male; MAP Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 3; Neuroprotective Agents; Nitriles; Rats; Rats, Wistar; Tacrolimus | 2010 |
Transient focal cerebral ischemia significantly alters not only EAATs but also VGLUTs expression in rats: relevance of changes in reactive astroglia.
Topics: Animals; Astrocytes; Blotting, Western; Caudate Nucleus; Cell Death; Cell Movement; Cerebral Cortex; Fluorescent Antibody Technique; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Immunohistochemistry; Infarction, Middle Cerebral Artery; Ischemic Attack, Transient; Microscopy, Confocal; Neuroglia; Neuronal Plasticity; Putamen; Rats; Reperfusion Injury; Vesicular Glutamate Transport Proteins | 2010 |
Treadmill pre-training suppresses the release of glutamate resulting from cerebral ischemia in rats.
Topics: Animals; Corpus Striatum; Exercise Test; Extracellular Space; Glutamic Acid; Infarction, Middle Cerebral Artery; Male; Models, Animal; Physical Conditioning, Animal; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Reperfusion Injury | 2010 |
Electroacupuncture at Baihui acupoint (GV20) reverses behavior deficit and long-term potentiation through N-methyl-d-aspartate and transient receptor potential vanilloid subtype 1 receptors in middle cerebral artery occlusion rats.
Topics: Acupuncture Points; Animals; Behavioral Symptoms; Biophysics; Disease Models, Animal; Electric Stimulation; Electroacupuncture; Gene Expression Regulation; Glutamic Acid; Hippocampus; In Vitro Techniques; Infarction, Middle Cerebral Artery; Long-Term Potentiation; Male; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Severity of Illness Index; Time Factors; TRPV Cation Channels | 2010 |
Treatment of cerebral ischemia by disrupting ischemia-induced interaction of nNOS with PSD-95.
Topics: Analysis of Variance; Animals; Biological Transport; Brain Ischemia; Cell Death; Disks Large Homolog 4 Protein; Glutamic Acid; Guanylate Kinases; Immunoprecipitation; Infarction, Middle Cerebral Artery; Intracellular Signaling Peptides and Proteins; Membrane Proteins; Mice; Microscopy, Confocal; Molecular Structure; Neuroprotective Agents; Nitric Oxide Synthase Type I; Oligonucleotides, Antisense; Rats; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Stroke | 2010 |
Neuroprotective effects and suppression of ischemia-induced glutamate elevation by β1-adrenoreceptor antagonists administered before transient focal ischemia in rats.
Topics: Adrenergic beta-1 Receptor Antagonists; Animals; Behavior, Animal; Blood Gas Analysis; Body Temperature; Brain Chemistry; Consciousness Disorders; Extracellular Space; Gait Disorders, Neurologic; Glutamic Acid; Hemodynamics; Infarction, Middle Cerebral Artery; Ischemic Attack, Transient; Male; Microdialysis; Morpholines; Neuroprotective Agents; Norepinephrine; Pain Threshold; Propanolamines; Rats; Rats, Sprague-Dawley; Reflex; Urea | 2011 |
Neuroprotection by glutamate oxaloacetate transaminase in ischemic stroke: an experimental study.
Topics: Animals; Aspartate Aminotransferases; Brain; Brain Ischemia; Cells, Cultured; Endothelial Cells; Enzyme Activation; Glutamic Acid; Infarction, Middle Cerebral Artery; Magnetic Resonance Imaging; Male; Neuroprotective Agents; Oxaloacetic Acid; Rats; Rats, Sprague-Dawley | 2011 |
KCa2 channels activation prevents [Ca2+]i deregulation and reduces neuronal death following glutamate toxicity and cerebral ischemia.
Topics: Animals; Brain Ischemia; Calcium Signaling; Cell Culture Techniques; Cell Death; Cells, Cultured; Excitatory Amino Acid Agonists; Glutamic Acid; Indoles; Infarction, Middle Cerebral Artery; Male; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neurons; Neuroprotective Agents; Oximes; Small-Conductance Calcium-Activated Potassium Channels; Transcription, Genetic | 2011 |
Effect of ginkgolide B on striatal extracellular amino acids in middle cerebral artery occluded rats.
Topics: Amino Acids; Animals; Aspartic Acid; Brain Ischemia; Corpus Striatum; gamma-Aminobutyric Acid; Ginkgo biloba; Ginkgolides; Glutamic Acid; Glycine; Infarction, Middle Cerebral Artery; Lactones; Male; Phytotherapy; Plant Extracts; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2011 |
Cerebroside-A provides potent neuroprotection after cerebral ischaemia through reducing glutamate release and Ca²⁺ influx of NMDA receptors.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Analysis of Variance; Animals; Brain Ischemia; Calcium; Cerebral Infarction; Cerebrosides; Charybdotoxin; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glucose; Glutamic Acid; Hippocampus; Hypoxia; In Vitro Techniques; Infarction, Middle Cerebral Artery; Long-Term Potentiation; Male; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neuroprotective Agents; Neurotoxins; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Tetrazolium Salts; Valine | 2012 |
Phosphoinositide 3-kinase enhancer regulates neuronal dendritogenesis and survival in neocortex.
Topics: Animals; Apoptosis; Brain-Derived Neurotrophic Factor; Cell Culture Techniques; Cell Survival; Dendrites; Glutamic Acid; GTP Phosphohydrolases; Infarction, Middle Cerebral Artery; Locomotion; Mice; Mice, Inbred C57BL; Mice, Knockout; Neocortex; Nerve Tissue Proteins; Neurogenesis; Neurons; Organ Size; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Signal Transduction; Spatial Behavior | 2011 |
Insulin and glucagon share the same mechanism of neuroprotection in diabetic rats: role of glutamate.
Topics: Analysis of Variance; Animals; Blood Glucose; Brain; Diabetes Mellitus, Experimental; Glucagon; Glutamic Acid; Hypoglycemic Agents; Infarction, Middle Cerebral Artery; Insulin; Male; Neuroprotective Agents; Oxaloacetic Acid; Rats; Rats, Sprague-Dawley; Time Factors | 2011 |
High-resolution spatial mapping of changes in the neurochemical profile after focal ischemia in mice.
Topics: Animals; Aspartic Acid; Brain Ischemia; gamma-Aminobutyric Acid; Glutamic Acid; Glutathione; Infarction, Middle Cerebral Artery; Ischemic Attack, Transient; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Inbred ICR; Models, Biological; Neostriatum; Neurochemistry; Taurine; Time Factors | 2012 |
Cleavage of the vesicular glutamate transporters under excitotoxic conditions.
Topics: Analysis of Variance; Animals; Apoptosis; Calpain; Caspase 3; Cells, Cultured; Embryo, Mammalian; Excitatory Amino Acid Agonists; Glucose; Glutamic Acid; Hippocampus; Hypoxia; Infarction, Middle Cerebral Artery; Neurons; Rats; Rats, Wistar; Synaptic Vesicles; Transfection; Vesicular Glutamate Transport Protein 1; Vesicular Glutamate Transport Protein 2 | 2011 |
Pyruvate's blood glutamate scavenging activity contributes to the spectrum of its neuroprotective mechanisms in a rat model of stroke.
Topics: Animals; Aspartate Aminotransferases; Brain Edema; Brain Infarction; Disease Models, Animal; Dose-Response Relationship, Drug; Glutamic Acid; Infarction, Middle Cerebral Artery; Male; Motor Activity; Neurologic Examination; Neuroprotective Agents; Oxaloacetic Acid; Pyruvic Acid; Random Allocation; Rats; Rats, Sprague-Dawley; Statistics, Nonparametric; Time Factors | 2011 |
Selective downregulation of N-methyl-D-aspartate receptor (NMDAR) rather than non-NMDAR subunits in ipsilateral cerebral hemispheres in rats with middle cerebral artery occlusion.
Topics: Animals; Calcium; CD11b Antigen; Cell Death; Cerebrum; Down-Regulation; Glutamic Acid; Infarction, Middle Cerebral Artery; Male; Microglia; Microtubule-Associated Proteins; Neurons; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Time Factors | 2011 |
Ferulic acid prevents the cerebral ischemic injury-induced decreases of astrocytic phosphoprotein PEA-15 and its two phosphorylated forms.
Topics: Animals; Apoptosis Regulatory Proteins; Cell Line; Cerebral Cortex; Coumaric Acids; Glutamic Acid; Infarction, Middle Cerebral Artery; Male; Mice; Neurons; Neuroprotective Agents; Phosphoproteins; Phosphorylation; Rats; Rats, Sprague-Dawley | 2012 |
Ischemic injury decreases parvalbumin expression in a middle cerebral artery occlusion animal model and glutamate-exposed HT22 cells.
Topics: Animals; Cell Line; Cell Survival; Disease Models, Animal; Glutamic Acid; Infarction, Middle Cerebral Artery; Male; Mice; Neurons; Parvalbumins; Rats; Rats, Sprague-Dawley | 2012 |
Melatonin regulates the calcium-buffering proteins, parvalbumin and hippocalcin, in ischemic brain injury.
Topics: Animals; Calcium; Cell Death; Cell Line; Disease Models, Animal; Dose-Response Relationship, Drug; Glutamic Acid; Hippocalcin; Hippocampus; Infarction, Middle Cerebral Artery; Male; Melatonin; Mice; Neurons; Neuroprotective Agents; Parvalbumins; Rats; Rats, Sprague-Dawley | 2012 |
Elucidation of neuroprotective role of endogenous GABA and energy metabolites middle cerebral artery occluded model in rats.
Topics: Adenosine Triphosphate; Animals; Aspartic Acid; Brain; Disease Models, Animal; Excitatory Amino Acids; gamma-Aminobutyric Acid; Glutamic Acid; Glutathione; Infarction, Middle Cerebral Artery; L-Lactate Dehydrogenase; Male; Neuroprotective Agents; Pyruvates; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Sodium-Potassium-Exchanging ATPase; Time Factors | 2012 |
Magnolol reduces glutamate-induced neuronal excitotoxicity and protects against permanent focal cerebral ischemia up to 4 hours.
Topics: Animals; Biphenyl Compounds; Brain; Calcium; Cells, Cultured; Cerebral Infarction; Dose-Response Relationship, Drug; Glutamic Acid; Infarction, Middle Cerebral Artery; Injections, Intraperitoneal; Lignans; Male; Neurons; Neuroprotective Agents; Neuropsychological Tests; Rats; Rats, Sprague-Dawley; Time Factors | 2012 |
Neurounina-1, a novel compound that increases Na+/Ca2+ exchanger activity, effectively protects against stroke damage.
Topics: Animals; Benzodiazepinones; Calcium; Cell Death; Cells, Cultured; Cricetinae; Dogs; Flumazenil; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Infarction, Middle Cerebral Artery; Male; Mice; Mice, Inbred C57BL; Mitochondria; Mutation; Neurons; Neuroprotective Agents; Patch-Clamp Techniques; Pyrrolidines; Rats; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Sodium-Calcium Exchanger; Stroke; Synaptosomes | 2013 |
Development of a pattern in biochemical parameters in the core and penumbra during infarct evolution after transient MCAO in rats.
Topics: Animals; Brain Ischemia; Glutamic Acid; Infarction, Middle Cerebral Artery; Leucine; Male; Monoamine Oxidase; Oxidative Stress; Protein Biosynthesis; Rats; Rats, Wistar; Stroke; Superoxide Dismutase | 2013 |
Honokiol protects brain against ischemia-reperfusion injury in rats through disrupting PSD95-nNOS interaction.
Topics: Animals; Biphenyl Compounds; Bisbenzimidazole; Blotting, Western; Cell Hypoxia; Cells, Cultured; Central Nervous System Depressants; Cerebral Cortex; Coloring Agents; Cytosol; Disks Large Homolog 4 Protein; Glucose; Glutamic Acid; Immunoprecipitation; In Vitro Techniques; Infarction, Middle Cerebral Artery; Intracellular Signaling Peptides and Proteins; L-Lactate Dehydrogenase; Lignans; Male; Membrane Proteins; Nitric Oxide; Nitric Oxide Synthase Type I; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reperfusion Injury; Translocation, Genetic | 2013 |
Transient lack of glucose but not O2 is involved in ischemic postconditioning-induced neuroprotection.
Topics: Animals; Brain Infarction; Chromatography, High Pressure Liquid; Disease Models, Animal; gamma-Aminobutyric Acid; Glucose; Glutamate-Ammonia Ligase; Glutamic Acid; Hypoxia; In Vitro Techniques; Infarction, Middle Cerebral Artery; Male; Mice; Mice, Inbred C57BL; Reperfusion; Time Factors | 2013 |
Ferulic acid prevents cerebral ischemic injury-induced reduction of hippocalcin expression.
Topics: Animals; Apoptosis; Calcium; Coumaric Acids; Down-Regulation; Glutamic Acid; Hippocalcin; Hippocampus; Infarction, Middle Cerebral Artery; Male; Neurons; Neuroprotective Agents; Proteomics; Rats; Rats, Sprague-Dawley; Transcription, Genetic | 2013 |
Iron intake increases infarct volume after permanent middle cerebral artery occlusion in rats.
Topics: Administration, Oral; Animals; Disease Models, Animal; Glutamic Acid; Infarction, Middle Cerebral Artery; Interleukin-6; Iron Overload; Iron, Dietary; Male; Oxidative Stress; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha | 2002 |
Neuroprotective effects of a novel non-receptor-binding estrogen analogue: in vitro and in vivo analysis.
Topics: Adamantane; Animals; Binding, Competitive; Blood Flow Velocity; Brain; Cell Line; Cell Survival; Cerebrovascular Circulation; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Carriers; Estradiol; Estradiol Congeners; Estrogen Receptor alpha; Estrogen Receptor beta; Estrone; Female; Glutamic Acid; Humans; Infarction, Middle Cerebral Artery; Ligands; Mice; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Receptors, Estrogen | 2002 |
Cardiovascular responses and neurotransmission in the ventrolateral medulla during skeletal muscle contraction following transient middle cerebral artery occlusion and reperfusion.
Topics: Animals; Cardiovascular System; Female; gamma-Aminobutyric Acid; Glutamic Acid; Infarction, Middle Cerebral Artery; Medulla Oblongata; Muscle Contraction; Muscle, Skeletal; Rats; Rats, Sprague-Dawley; Reperfusion | 2002 |
Uptake of glutamate is impaired in the cortical penumbra of the rat following middle cerebral artery occlusion: an in vivo microdialysis extraction study.
Topics: Animals; Cell Death; Cerebral Cortex; Glutamic Acid; Infarction, Middle Cerebral Artery; Male; Membrane Potentials; Microdialysis; Rats; Rats, Wistar | 2003 |
EDT, a tetrahydroacridine derivative inhibits cerebral ischemia and protects rat cortical neurons against glutamate-induced cytotoxicity.
Topics: Acridines; Animals; Brain Ischemia; Cell Division; Cells, Cultured; Female; Glutamic Acid; Infarction, Middle Cerebral Artery; L-Lactate Dehydrogenase; Male; Mice; Neurons; Neuroprotective Agents; Nitric Oxide; Nitroprusside; Random Allocation; Rats; Rats, Wistar | 2003 |
Inhibition of glutamate release by delaying ATP fall accounts for neuroprotective effects of antioxidants in experimental stroke.
Topics: Adenosine Triphosphate; Animals; Antioxidants; Brain; Cell Respiration; Electron Transport; Glutamic Acid; Glutathione; Infarction, Middle Cerebral Artery; Kinetics; Male; Metalloporphyrins; Mitochondria; Models, Biological; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Inbred F344; Reactive Oxygen Species; Stroke; Tocopherols; Treatment Outcome | 2003 |
Relationship between glutamate in the limbic system and hypothalamus-pituitary-adrenal axis after middle cerebral artery occlusion in rats.
Topics: Animals; Glutamic Acid; Hypothalamo-Hypophyseal System; Infarction, Middle Cerebral Artery; Limbic System; Male; Pituitary-Adrenal System; Rats; Rats, Wistar; Reperfusion Injury | 2003 |
[Cerebral microdialysis in stroke].
Topics: Brain Edema; Critical Care; Diagnostic Imaging; Electrolytes; Energy Metabolism; Glutamic Acid; Glycerol; Humans; Hypothermia, Induced; Infarction, Middle Cerebral Artery; Lactic Acid; Microdialysis; Monitoring, Physiologic; Nerve Tissue Proteins; Neurologic Examination; Neurotransmitter Agents; Oximetry; Oxygen Consumption; Predictive Value of Tests; Prognosis; Pseudotumor Cerebri; Pyruvic Acid; Reference Values; Water-Electrolyte Balance | 2004 |
Neurotransmitter release in experimental stroke models: the role of glutamate-GABA interaction.
Topics: Action Potentials; Animals; Brain; D-Aspartic Acid; Disease Models, Animal; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Hypoxia; In Vitro Techniques; Infarction, Middle Cerebral Artery; Neural Pathways; Neurons; Stroke; Tetrazolium Salts; Tritium | 2004 |
Volume-regulated anion channels are the predominant contributors to release of excitatory amino acids in the ischemic cortical penumbra.
Topics: Amino Acid Transport System X-AG; Animals; Anion Transport Proteins; Aspartic Acid; Astrocytes; Brain Ischemia; Cerebral Cortex; Excitatory Amino Acids; Glutamic Acid; Infarction, Middle Cerebral Artery; Kainic Acid; Microdialysis; Neurons; Rats; Receptors, Glutamate; Tamoxifen; Taurine | 2004 |
Estrogen attenuates neuronal excitability in the insular cortex following middle cerebral artery occlusion.
Topics: Action Potentials; Animals; Cerebral Cortex; Disease Models, Animal; Down-Regulation; Estrogens; gamma-Aminobutyric Acid; Glutamic Acid; Infarction, Middle Cerebral Artery; Male; Nerve Degeneration; Neural Inhibition; Neurons; Neuroprotective Agents; Neurotoxins; Rats; Rats, Sprague-Dawley; Sympathetic Nervous System; Up-Regulation | 2004 |
Neurochemical monitoring of glycerol therapy in patients with ischemic brain edema.
Topics: Adult; Aged; Brain; Brain Edema; Drug Monitoring; Edema; Female; Glutamic Acid; Glycerol; Humans; Infarction, Middle Cerebral Artery; Intracranial Pressure; Lactic Acid; Male; Middle Aged; Middle Cerebral Artery; Models, Statistical; Osmolar Concentration; Osmosis; Pyruvic Acid; Time Factors; Tomography, X-Ray Computed; Treatment Outcome | 2005 |
Astrocytic function assessed from 1-14C-acetate metabolism after temporary focal cerebral ischemia in rats.
Topics: Acetates; Animals; Astrocytes; Blood Gas Analysis; Cerebral Cortex; Glutamic Acid; Glutamine; Hemodynamics; Infarction, Middle Cerebral Artery; Ischemic Attack, Transient; Male; Neostriatum; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2005 |
Identification of neuroprotective properties of anti-MAG antibody: a novel approach for the treatment of stroke?
Topics: Animals; Antibodies, Monoclonal; Brain; Cell Death; Dose-Response Relationship, Drug; Glutamic Acid; Immunoglobulin G; Infarction, Middle Cerebral Artery; Male; Mice; Myelin Sheath; Myelin-Associated Glycoprotein; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Sprague-Dawley; Regeneration; Stroke | 2005 |
Inhibition of iNOS activity by 1400W decreases glutamate release and ameliorates stroke outcome after experimental ischemia.
Topics: Adenosine Triphosphate; Amidines; Amino Acid Transport System X-AG; Animals; Benzylamines; Brain; Cerebral Infarction; Cytoprotection; Disease Models, Animal; Down-Regulation; Enzyme Inhibitors; Glutamic Acid; Infarction, Middle Cerebral Artery; Ischemic Attack, Transient; Male; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; Stroke; Treatment Outcome | 2005 |
Minocycline inhibits oxidative stress and decreases in vitro and in vivo ischemic neuronal damage.
Topics: Animals; Antioxidants; Benzimidazoles; Benzoxazoles; Biphenyl Compounds; Brain Edema; Brain Infarction; Cell Death; Cell Survival; Cells, Cultured; Cerebral Cortex; Chromans; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; Fluorescent Dyes; Glutamic Acid; Hydrazines; Infarction, Middle Cerebral Artery; Inhibitory Concentration 50; Ischemia; Lipid Peroxidation; Male; Mice; Minocycline; Neurons; Neuroprotective Agents; Oxidative Stress; Picrates; Quinolinium Compounds; Saponins; Tetrazolium Salts; Time Factors | 2005 |
TNFR1 mediates increased neuronal membrane EAAT3 expression after in vivo cerebral ischemic preconditioning.
Topics: ADAM Proteins; ADAM17 Protein; Animals; Antibodies; Brain Ischemia; Cell Membrane; Cerebral Cortex; Disease Models, Animal; Enzyme Inhibitors; Excitatory Amino Acid Transporter 2; Excitatory Amino Acid Transporter 3; Glutamic Acid; Infarction, Middle Cerebral Artery; Ischemic Preconditioning; Male; Neurons; Oligodeoxyribonucleotides, Antisense; Rats; Rats, Inbred F344; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Tumor Necrosis Factor Decoy Receptors; Tumor Necrosis Factor-alpha; Up-Regulation | 2006 |
Protective effect of zinc against ischemic neuronal injury in a middle cerebral artery occlusion model.
Topics: Animals; Calcium; Calcium Radioisotopes; Cell Culture Techniques; Cell Survival; Cells, Cultured; Chelating Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Ethylenediamines; Glutamic Acid; Hippocampus; Immunohistochemistry; Infarction, Middle Cerebral Artery; Injections, Intraventricular; Neurons; Protective Agents; Rats; Zinc | 2006 |
[Protective effect of hydroxysafflor yellow A on experimental cerebral ischemia in rats].
Topics: Animals; Behavior, Animal; Brain; Brain Ischemia; Carthamus tinctorius; Cells, Cultured; Cerebral Cortex; Chalcone; Glutamic Acid; Infarction, Middle Cerebral Artery; L-Lactate Dehydrogenase; Male; Neurons; Neuroprotective Agents; Plants, Medicinal; Quinones; Rats; Rats, Inbred WKY; Sodium Cyanide | 2005 |
The metabolism of C-glucose by neurons and astrocytes in brain subregions following focal cerebral ischemia in rats.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Astrocytes; Brain; Brain Infarction; Brain Ischemia; Carbon Radioisotopes; Cell Communication; Cell Death; Disease Models, Animal; Down-Regulation; Energy Metabolism; Glucose; Glutamic Acid; Glutamine; Infarction, Middle Cerebral Artery; Male; Neurons; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2006 |
Estradiol prevents the injury-induced decrease of Akt/glycogen synthase kinase 3beta phosphorylation.
Topics: Animals; Apoptosis; Blotting, Western; Brain; Brain Infarction; Cell Line; Enzyme Activation; Estradiol; Female; Glutamic Acid; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Immunohistochemistry; In Situ Nick-End Labeling; In Vitro Techniques; Infarction, Middle Cerebral Artery; Neuroprotective Agents; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley | 2006 |
Neuroprotectant FK506 inhibits glutamate-induced apoptosis of astrocytes in vitro and in vivo.
Topics: Animals; Apoptosis; Astrocytes; Blotting, Western; Caspases; Cell Size; Cell Survival; Cells, Cultured; Cerebral Cortex; DNA Fragmentation; Enzyme Activation; Excitatory Amino Acid Antagonists; Fluorescent Dyes; Glial Fibrillary Acidic Protein; Glutamic Acid; In Situ Nick-End Labeling; Indoles; Infarction, Middle Cerebral Artery; Male; Membrane Potentials; Mitochondria; Neuroprotective Agents; Rats; Reperfusion Injury; Tacrolimus; Tetrazolium Salts; Thiazoles | 2006 |
Ischemic preconditioning reveals that GLT1/EAAT2 glutamate transporter is a novel PPARgamma target gene involved in neuroprotection.
Topics: Animals; Astrocytes; Benzamides; Blotting, Western; Brain; Cells, Cultured; Chromatography, High Pressure Liquid; Coculture Techniques; Excitatory Amino Acid Transporter 2; Gene Expression; Glutamic Acid; Hypoglycemic Agents; Infarction, Middle Cerebral Artery; Ischemic Preconditioning; Male; Neurons; PPAR gamma; Promoter Regions, Genetic; Pyridines; Rats; Rats, Inbred F344; Rats, Wistar; Response Elements; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Rosiglitazone; Thiazolidinediones | 2007 |
Effects of cervical-lymphatic blockade on brain edema and infarction volume in cerebral ischemic rats.
Topics: Animals; Blotting, Northern; Brain; Brain Edema; Calcium; Glutamic Acid; Infarction, Middle Cerebral Artery; Lymphatic Vessels; Male; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Water | 2006 |
A microdialysis study of effects of gastrodin on neurochemical changes in the ischemic/reperfused rat cerebral hippocampus.
Topics: Animals; Benzyl Alcohols; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Extracellular Space; gamma-Aminobutyric Acid; Glucosides; Glutamic Acid; Hippocampus; Infarction, Middle Cerebral Artery; Injections, Intraperitoneal; Ischemic Attack, Transient; Male; Microdialysis; Neurons; Neuroprotective Agents; Neurotransmitter Agents; Rats; Rats, Sprague-Dawley; Reperfusion; Time Factors | 2007 |
Delayed treatment with cannabidiol has a cerebroprotective action via a cannabinoid receptor-independent myeloperoxidase-inhibiting mechanism.
Topics: Animals; Behavior, Animal; Cannabidiol; Cerebrovascular Circulation; Disease Models, Animal; Dose-Response Relationship, Drug; Dronabinol; Functional Laterality; Glutamic Acid; Infarction, Middle Cerebral Artery; Male; Mice; Motor Activity; Neuroprotective Agents; Perfusion; Peroxidase; Piperidines; Pyrazoles; Receptors, Cannabinoid; Rimonabant; Tetrazolium Salts; Time Factors | 2007 |
Synaptic plasticity during recovery from permanent occlusion of the middle cerebral artery.
Topics: Animals; Corpus Striatum; Excitatory Postsynaptic Potentials; Glutamic Acid; Infarction, Middle Cerebral Artery; Interneurons; Male; Neuronal Plasticity; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Recovery of Function; Synaptic Transmission | 2007 |
PGD(2) DP1 receptor protects brain from ischemia-reperfusion injury.
Topics: Animals; Blood Gas Analysis; Blood Pressure; Body Temperature; Cells, Cultured; Glutamic Acid; Hydantoins; Hypoxia-Ischemia, Brain; Infarction, Middle Cerebral Artery; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Prostaglandin D2; Receptors, Immunologic; Receptors, Prostaglandin | 2007 |
Neuroprotective effects of a standardized extract of Diospyros kaki leaves on MCAO transient focal cerebral ischemic rats and cultured neurons injured by glutamate or hypoxia.
Topics: Administration, Oral; Animals; Brain Ischemia; Cerebral Cortex; Diospyros; Dose-Response Relationship, Drug; Glutamic Acid; Hippocampus; Infarction, Middle Cerebral Artery; Male; Neurons; Neuroprotective Agents; Phytotherapy; Plant Extracts; Plant Leaves; Rats; Rats, Sprague-Dawley | 2007 |
Delayed post-ischemic administration of CDP-choline increases EAAT2 association to lipid rafts and affords neuroprotection in experimental stroke.
Topics: Animals; Cell Fractionation; Cytidine Diphosphate Choline; Disease Models, Animal; Excitatory Amino Acid Transporter 2; Gene Expression Regulation; Glutamic Acid; Infarction, Middle Cerebral Artery; Male; Membrane Microdomains; Neuroprotective Agents; Rats; Rats, Inbred F344; Time Factors | 2008 |
Early release of HMGB-1 from neurons after the onset of brain ischemia.
Topics: Animals; Antibodies; Astrocytes; Brain Ischemia; Cells, Cultured; Culture Media, Conditioned; Encephalitis; Endothelial Cells; Extracellular Space; Glutamic Acid; HMGB1 Protein; Infarction, Middle Cerebral Artery; Male; Mice; Mice, Inbred C57BL; Neurons; Receptor for Advanced Glycation End Products; Receptors, Immunologic; RNA, Messenger; Toll-Like Receptor 2; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha | 2008 |
Evaluation of the neuroprotective effect of ketoprofen on rats submitted to permanent focal brain ischemia.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Glutamic Acid; Infarction, Middle Cerebral Artery; Ketoprofen; Neuroprotective Agents; Rats; Rats, Wistar; Time Factors | 2007 |
Pulse inhibition of histone deacetylases induces complete resistance to oxidative death in cortical neurons without toxicity and reveals a role for cytoplasmic p21(waf1/cip1) in cell cycle-independent neuroprotection.
Topics: Analysis of Variance; Animals; Cell Cycle; Cell Death; Cells, Cultured; Cerebral Cortex; Cyclin-Dependent Kinase Inhibitor p21; Drug Interactions; Embryo, Mammalian; Enzyme Inhibitors; Glutamic Acid; Green Fluorescent Proteins; Hippocampus; Histone Deacetylase Inhibitors; Histone Deacetylases; Infarction, Middle Cerebral Artery; Neurons; Oxidative Stress; Rats; Rats, Sprague-Dawley; Transfection | 2008 |
DCPIB, a specific inhibitor of volume regulated anion channels (VRACs), reduces infarct size in MCAo and the release of glutamate in the ischemic cortical penumbra.
Topics: Animals; Aspartic Acid; Brain Infarction; Chromatography, High Pressure Liquid; Cyclopentanes; Dialysis; Disease Models, Animal; Drug Administration Routes; Fluorenes; Glutamic Acid; Indans; Infarction, Middle Cerebral Artery; Male; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Statistics, Nonparametric; Tetrazolium Salts | 2008 |
Inhibited glutamate release by granulocyte-colony stimulating factor after experimental stroke.
Topics: Animals; Brain Infarction; Corpus Striatum; Disease Models, Animal; Glutamic Acid; Granulocyte Colony-Stimulating Factor; Infarction, Middle Cerebral Artery; Male; Rats; Rats, Wistar; Time Factors | 2008 |
Neurochemical monitoring of therapeutic effects in large human MCA infarction.
Topics: Craniotomy; Critical Care; Female; Glutamic Acid; Glycerol; Humans; Hypothermia, Induced; Infarction, Middle Cerebral Artery; Lactic Acid; Male; Microdialysis; Middle Aged; Prospective Studies; Pyruvic Acid; Treatment Outcome | 2008 |
Effect of combined ultrasound and microbubbles treatment in an experimental model of cerebral ischemia.
Topics: Animals; Biomarkers; Brain Ischemia; Glutamic Acid; Glycerol; Infarction, Middle Cerebral Artery; Lactic Acid; Male; Microbubbles; Microdialysis; Middle Cerebral Artery; Models, Animal; Pyruvic Acid; Rats; Rats, Wistar; Sulfur Hexafluoride; Thrombolytic Therapy; Ultrasonography | 2008 |
Blockade of NAALADase: a novel neuroprotective strategy based on limiting glutamate and elevating NAAG.
Topics: Animals; Carboxypeptidases; Dipeptides; Glutamate Carboxypeptidase II; Glutamic Acid; Infarction, Middle Cerebral Artery; Neuroprotective Agents; Organophosphorus Compounds; Rats; Reperfusion Injury | 1999 |
Fractalkine cleavage from neuronal membranes represents an acute event in the inflammatory response to excitotoxic brain damage.
Topics: Animals; Animals, Newborn; Brain; Cell Membrane; Cells, Cultured; Chemokine CX3CL1; Chemokines, CX3C; Chemotaxis; Culture Media, Conditioned; Disease Models, Animal; Encephalitis; Endothelium, Vascular; Glutamic Acid; Infarction, Middle Cerebral Artery; Interleukin-1; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Membrane Proteins; Microglia; Monocytes; Neurons; Phenylalanine; Protease Inhibitors; Rats; RNA, Messenger; Thiophenes; Transfection; Tumor Necrosis Factor-alpha | 2000 |
Diethylmaleate decreased ascorbic acid release induced by cerebral ischemia in cerebral cortex of the anesthetized rat.
Topics: Amino Acid Transport System X-AG; Anesthesia; Animals; Ascorbic Acid; Brain Chemistry; Brain Ischemia; Carrier Proteins; Cerebral Cortex; Dicarboxylic Acids; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Extracellular Space; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Glutathione; Infarction, Middle Cerebral Artery; Male; Maleates; Microdialysis; Neurotransmitter Uptake Inhibitors; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Symporters | 2000 |
Inhibition of evoked glutamate release by the neuroprotective 5-HT(1A) receptor agonist BAY x 3702 in vitro and in vivo.
Topics: Animals; Aspartic Acid; Benzopyrans; Brain Ischemia; Disease Models, Animal; Dose-Response Relationship, Drug; Extracellular Space; Glutamic Acid; Hippocampus; Infarction, Middle Cerebral Artery; Male; Microdialysis; Neuroprotective Agents; Organ Culture Techniques; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists; Synaptic Transmission; Thiazoles | 2001 |
Adaptive plasticity in tachykinin and tachykinin receptor expression after focal cerebral ischemia is differentially linked to gabaergic and glutamatergic cerebrocortical circuits and cerebrovenular endothelium.
Topics: Animals; Brain Ischemia; Cerebral Cortex; Cerebrovascular Circulation; Endothelium, Vascular; gamma-Aminobutyric Acid; Gene Expression Regulation; Glutamic Acid; Infarction, Middle Cerebral Artery; Male; Neurokinin B; Neuronal Plasticity; Protein Precursors; Rats; Rats, Long-Evans; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Receptors, Tachykinin; RNA, Messenger; Substance P; Tachykinins; Venules | 2001 |
Real-time measurement of glutamate release from the ischemic penumbra of the rat cerebral cortex using a focal middle cerebral artery occlusion model.
Topics: Animals; Brain Ischemia; Cerebral Cortex; Cerebrovascular Circulation; Cortical Spreading Depression; Disease Models, Animal; Electrodes; Electroencephalography; Glutamic Acid; Infarction, Middle Cerebral Artery; Male; Membrane Potentials; Rats; Rats, Sprague-Dawley; Time Factors | 2001 |
Characterization of transient focal ischemia-induced increases in extracellular glutamate and aspartate in spontaneously hypertensive rats.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding Cassette Transporters; Brain; Brain Ischemia; Extracellular Space; Glutamic Acid; Infarction, Middle Cerebral Artery; Kainic Acid; Male; Rats; Rats, Inbred SHR; Reperfusion Injury; Tetrodotoxin; Time Factors | 2000 |
Antisense knockdown of the glial glutamate transporter GLT-1, but not the neuronal glutamate transporter EAAC1, exacerbates transient focal cerebral ischemia-induced neuronal damage in rat brain.
Topics: Amino Acid Transport System X-AG; Animals; ATP-Binding Cassette Transporters; Blood Flow Velocity; Brain; Carrier Proteins; Cerebral Cortex; Cerebrovascular Circulation; Corpus Striatum; Disease Progression; Excitatory Amino Acid Transporter 3; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Infarction, Middle Cerebral Artery; Ischemic Attack, Transient; Male; Neuroglia; Neurons; Oligonucleotides, Antisense; Rats; Rats, Inbred SHR; Survival Rate; Symporters | 2001 |
Middle cerebral artery occlusion and reperfusion in primates monitored by microdialysis and sequential positron emission tomography.
Topics: Animals; Brain; Brain Ischemia; Cerebrovascular Circulation; Glutamic Acid; Hypoxanthine; Infarction, Middle Cerebral Artery; Lactic Acid; Macaca mulatta; Microdialysis; Oxygen Consumption; Pyruvic Acid; Reperfusion Injury; Tomography, Emission-Computed | 2001 |
Increase of interstitial glycerol reflects the degree of ischaemic brain damage: a PET and microdialysis study in a middle cerebral artery occlusion-reperfusion primate model.
Topics: Animals; Brain Damage, Chronic; Extracellular Space; Glutamic Acid; Glycerol; Infarction, Middle Cerebral Artery; Lactic Acid; Macaca mulatta; Microdialysis; Oxygen Consumption; Phospholipids; Pyruvic Acid; Reperfusion Injury; Tomography, Emission-Computed | 2001 |
Effect of hyperbaric oxygen on striatal metabolites: a microdialysis study in awake freely moving rats after MCA occlusion.
Topics: Animals; Brain Ischemia; Corpus Striatum; Energy Metabolism; Extracellular Space; Glucose; Glutamic Acid; Hyperbaric Oxygenation; Infarction, Middle Cerebral Artery; Lactic Acid; Male; Microdialysis; Movement; Neurons; Pyruvic Acid; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Time Factors; Wakefulness | 2001 |
Neuroprotective actions in vivo and electrophysiological actions in vitro of 202W92.
Topics: Animals; Brain Ischemia; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Cerebral Infarction; Dose-Response Relationship, Drug; Excitatory Postsynaptic Potentials; Glutamic Acid; Infarction, Middle Cerebral Artery; Male; Membrane Potentials; Nerve Degeneration; Neurons; Neuroprotective Agents; Patch-Clamp Techniques; Pyrimidines; Rats; Rats, Inbred F344; Sodium Channel Blockers; Sodium Channels; Substantia Nigra; Synaptic Transmission; Telencephalon | 2001 |
Neurometabolic changes during treatment with moderate hypothermia in a patient suffering from severe middle cerebral artery infarction.
Topics: Adult; Brain Ischemia; Extracellular Space; Glutamic Acid; Glycerol; Humans; Hypothermia, Induced; Infarction, Middle Cerebral Artery; Lactic Acid; Microdialysis; Pyruvic Acid; Tomography, X-Ray Computed | 2001 |
Differences in neurotransmitter synthesis and intermediary metabolism between glutamatergic and GABAergic neurons during 4 hours of middle cerebral artery occlusion in the rat: the role of astrocytes in neuronal survival.
Topics: Acetate-CoA Ligase; Alanine; Anesthetics, Inhalation; Animals; Aspartic Acid; Astrocytes; Blood Glucose; Carbon Isotopes; Cell Communication; Cell Survival; Citric Acid Cycle; Energy Metabolism; Frontal Lobe; gamma-Aminobutyric Acid; Glucose; Glutamic Acid; Glutamine; Infarction, Middle Cerebral Artery; Isoflurane; Magnetic Resonance Spectroscopy; Male; Neostriatum; Neurons; Parietal Lobe; Rats; Rats, Wistar | 2001 |
Changes in dopaminergic and glutamatergic excitatory mechanisms of micturition reflex after middle cerebral artery occlusion in conscious rats.
Topics: Animals; Dizocilpine Maleate; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Infarction, Middle Cerebral Artery; Quinpirole; Rats; Rats, Sprague-Dawley; Reflex; Sulpiride; Urinary Bladder; Urinary Bladder, Neurogenic; Urination; Wakefulness | 2002 |
Inhibition of glial glutamate transporter GLT-1 augments brain edema after transient focal cerebral ischemia in mice.
Topics: Animals; Brain; Brain Edema; Brain Ischemia; Excitatory Amino Acid Transporter 2; Extracellular Space; Female; Glutamic Acid; Infarction, Middle Cerebral Artery; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuroglia; Neurotoxins; Neurotransmitter Uptake Inhibitors; Reperfusion Injury; Water-Electrolyte Balance | 2002 |
Persistent defect in transmitter release and synapsin phosphorylation in cerebral cortex after transient moderate ischemic injury.
Topics: Animals; Calcium-Binding Proteins; Cerebral Cortex; Disease Progression; Glutamic Acid; Infarction, Middle Cerebral Artery; Ischemic Attack, Transient; Membrane Glycoproteins; Nerve Tissue Proteins; Neurons; Neurotransmitter Agents; Phosphorylation; Phosphotyrosine; Rats; Rats, Wistar; Synapsins; Synaptic Transmission; Synaptophysin; Synaptotagmins; Time | 2002 |
Malignant infarction in cats after prolonged middle cerebral artery occlusion: glutamate elevation related to decrease of cerebral perfusion pressure.
Topics: Animals; Blood Flow Velocity; Blood Pressure; Brain; Brain Edema; Cats; Cerebral Infarction; Cerebrovascular Circulation; Disease Models, Animal; Disease Progression; Glutamic Acid; Infarction, Middle Cerebral Artery; Intracranial Pressure; Laser-Doppler Flowmetry; Microdialysis; Predictive Value of Tests; Tomography, Emission-Computed | 2002 |
A neuroprotective role for gap junctions.
Topics: Animals; Astrocytes; Brain Ischemia; Carbenoxolone; Cell Communication; Cells, Cultured; Central Nervous System; Coculture Techniques; Connexin 43; Disease Models, Animal; Gap Junctions; Glutamic Acid; In Situ Nick-End Labeling; Infarction, Middle Cerebral Artery; Mice; Mice, Knockout; Neurons | 2001 |