glutamic acid and Glaucoma

glutamic acid has been researched along with Glaucoma in 68 studies

Research

Studies (68)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	7 (10.29)	18.2507
2000's	34 (50.00)	29.6817
2010's	16 (23.53)	24.3611
2020's	11 (16.18)	2.80

Authors

Authors	Studies
Abd Ghapor, AA; Agarwal, R; Hann Yih, T; Iezhitsa, I; Mohd Ismail, N; Razali, N	1
Brahma, MM; Goshima, Y; Harada, T; Namekata, K; Ohshima, T; Takahashi, K	1
Dai, Y; Liu, H; Zhang, R; Zhuang, D	1
Li, H; Rong, R; Xia, X; You, M; Zeng, Z	1
Huang, JF; Liao, LS; Liu, SM; Wang, SC	1
Ji, D; Li, H; Liu, M; Xia, X; Yang, R	1
An, Y; Ding, L; Li, H; Song, S; Wang, C; Xia, X; Xia, Z; Zhou, X	1
A, L; Chen, S; Gao, H; Xie, J; Xu, H; Yin, ZQ	1
Bang, JW; Chan, KC; Parra, C; Schuman, JS; Wollstein, G; Yu, K	1
Londhe, VY; Sharma, S; Yadav, KS	1
Koizumi, S; Shinozaki, Y	1
Guo, L; Huang, P; Huang, S; Lin, Z; Shen, X; Xie, B; Xu, X; Zhong, Y	1
Choi, SJ; Jo, H; Jung, SH	1
Mykheĭtseva, IM	1
Ju, WK; Kim, H; Kim, KY; Kim, SY; Lee, D; Noh, YH; Shim, MS; Weinreb, RN	1
Czeizel, E; Kádasi, ĽL; Vogt, G	1
Xiong, S; Xu, X	1
Chen, JY; Chen, XY; Gao, F; Gao, FJ; Luo, Y; Nickerson, JM; Sun, XH; Sun, Z; Wang, Y; Wu, JH; Zhang, SH; Zhang, SJ	1
Ellisman, MH; Hoshijima, M; Ju, WK; Kim, KY; Lukas, TJ; Noh, YH; Perkins, GA; Weinreb, RN	1
Aida, T; Harada, T; Namekata, K; Shinagawa, R; Takeda, T; Tanaka, K; Yanagisawa, M	1
Jung, KI; Kim, JH; Park, CK	1
Dada, T; Faiq, MA	1
London, A; Schwartz, M	1
Cordeiro, MF; Guo, L	1
Bagetta, G; Cavaliere, F; Cerulli, A; Corasaniti, MT; Fazzi, E; Gliozzi, M; Morrone, LA; Nucci, C; Rombolà, L; Russo, R	1
Bagetta, G; Cavaliere, F; Corasaniti, MT; Morrone, LA; Nucci, C; Russo, R; Sakurada, S; Watanabe, C	1
Charalambous, P; Schallenberg, M; Thanos, S	1
Bagetta, G; Bucci, MG; Corasaniti, MT; Morrone, LA; Nucci, C; Rotiroti, D; Russo, R; Tassorelli, C	1
Fuse, N; Guo, X; Harada, C; Harada, T; Kikushima, K; Kimura, A; Kohyama, K; Matsumoto, Y; Mitamura, Y; Namekata, K; Tanaka, K	1
Belforte, NA; Chianelli, MS; de Zavalía, N; Keller Sarmiento, MI; Moreno, MC; Rosenstein, RE; Sande, PH	1
Pinar-Sueiro, S; Rodríguez-Puertas, R; Vecino, E	1
Chader, GJ	1
Fu, CT; Sretavan, DW	1
Ishii, K; Mori, A; Nakahara, T; Sakamoto, K; Tsuda, Y; Ueda, K	1
Goto, W; Hara, H; Kawazu, K; Miyawaki, N; Morikawa, N; Ota, T; Otori, Y; Tano, Y	1
Roque, RS; Srinivasan, B; Taylor, S; Wordinger, RJ	1
Fong, JC; Hong, SJ; Wang, HZ; Wu, KY	1
Amara, SG; Coimbra, NC; Coutinho-Netto, J; de Oliveira Beleboni, R; dos Santos, WF; Fontana, AC; Guizzo, R; Meirelles E Silva, AR	1
Ruiz, G; Wijono, M; Woldemussie, E	1
Dubielzig, RR; Gionfriddo, JR; Madl, JE; McIlnay, TR; Powell, CC	1
Chun, T; Hare, WA; Lai, RK; Ruiz, G; Ton, H; Wheeler, L; WoldeMussie, E	1
Clark, AF; Li, B; Pang, IH	1
Case, GL; Dahl, DB; Gabelt, BT; Hernandez, MR; Kaufman, PL; May, CA; Sherwood, RW; Wamsley, S	1
Lotery, AJ	1
de Zavalía, N; Keller Sarmiento, MI; Marcos, HA; Moreno, MC; Rosenstein, RE; Sande, P	1
Gionfriddo, JR; Madl, JE; McIlnay, TR; Powell, CC	1
Cordeiro, MF; Salt, TE	1
Baldridge, WH; Chauhan, BC; Hartwick, AT; Zhang, X	1
Ikeda, T; Oku, H; Okuno, T; Sugiyama, T	1
Cordeiro, MF; Fitzke, FW; Guo, L; Luong, V; Maass, A; Moss, SE; Salt, TE	1
Gionfriddo, JR; Low, HC; Madl, JE	1
Macnab, L; Pow, DV; Ruiz, G; Sullivan, RK; Woldemussie, E	1
Leung, CK; Pang, CP; Zhong, YS	1
Fan, SS; Huang, SY; Lai, CC; Lee Chao, PD; Lin, HJ; Tsai, FJ; Tsai, Y; Wan, L	1
Aihara, M; Harada, C; Harada, T; Mitani, A; Nakamura, K; Namekata, K; Okumura, A; Quah, HM; Saeki, T; Tanaka, K; Yoshida, H	1
Chen, HZ; Cui, YY; Qi, H; Ren, QS; Wang, H; Zhou, W; Zhu, L; Zhu, X	1
Dreyer, EB; Lipton, SA; Podos, SM; Schumer, RA; Zurakowski, D	1
Bonne, C; Muller, A; Villain, M	1
Dreyer, EB	1
Alvarez, A; Esquivel, F; Franco-Bourland, RE; García, GA; Guízar-Sahagún, G; Odor-Morales, A; Rodríguez, S	1
Bae, JH; Chidlow, G; Melena, J; Nash, MS; Osborne, NN; Wood, JP	1
Dreyer, EB; Gorla, MS; Vorwerk, CK	1
Dreyer, EB; Naskar, R; Vorwerk, CK	1
Ritch, R	1
Agarwal, N; Agarwal, P; Clark, AF; Krishnamoorthy, RR; Lambert, W; Pang, IH; Prasanna, G; Shade, D; Sheedlo, HJ; Vopat, K; Wordinger, RJ; Yorio, T	1
Kipnis, J; Ruiz, G; Schori, H; Schwartz, M; Wheeler, LA; WoldeMussie, E; Yoles, E	1
Hartwick, AT	1
Dalton, R	1

Reviews

16 review(s) available for glutamic acid and Glaucoma

Article	Year
Bio-tactics for neuroprotection of retinal ganglion cells in the treatment of glaucoma. Life sciences, 2020, Feb-15, Volume: 243 Topics: Animals; Genetic Therapy; Glaucoma; Glutamic Acid; Humans; Intraocular Pressure; Neuroprotection; Neuroprotective Agents; Retinal Ganglion Cells	2020
Potential roles of astrocytes and Müller cells in the pathogenesis of glaucoma. Journal of pharmacological sciences, 2021, Volume: 145, Issue:3 Topics: Astrocytes; Complement C3; Ependymoglial Cells; Glaucoma; Gliosis; Glutamic Acid; Humans; Intraocular Pressure; Nerve Growth Factors; Optic Disk; Retina; Risk Factors; STAT3 Transcription Factor	2021
[The option of neuroprotective therapeutics for glaucoma]. [Zhonghua yan ke za zhi] Chinese journal of ophthalmology, 2014, Volume: 50, Issue:8 Topics: Apoptosis; Drug Interactions; Glaucoma; Glutamic Acid; Humans; Nerve Growth Factors; Neuroprotective Agents; Receptors, N-Methyl-D-Aspartate; Retinal Ganglion Cells	2014
Diabetes Type 4: A Paradigm Shift in the Understanding of Glaucoma, the Brain Specific Diabetes and the Candidature of Insulin as a Therapeutic Agent. Current molecular medicine, 2017, Volume: 17, Issue:1 Topics: Amyloid; Animals; Brain; Diabetes Mellitus; Glaucoma; Glutamic Acid; Humans; Inflammation; Insulin; Insulin Antagonists; Mitochondria; Organ Specificity; Oxidative Stress; Protein Binding; Signal Transduction; tau Proteins	2017
Assessment of neuroprotection in the retina with DARC. Progress in brain research, 2008, Volume: 173 Topics: Amyloid beta-Peptides; Animals; Apoptosis; Clinical Trials as Topic; Disease Models, Animal; Glaucoma; Glutamic Acid; Humans; Lasers; Neuroprotective Agents; Ophthalmoscopes; Ophthalmoscopy; Retinal Ganglion Cells; Ubiquinone; Visual Field Tests; Visual Fields; Vitamins	2008
Identification of novel pharmacological targets to minimize excitotoxic retinal damage. International review of neurobiology, 2009, Volume: 85 Topics: Animals; Cell Death; Drug Delivery Systems; Glaucoma; Glutamic Acid; Nerve Growth Factors; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Reperfusion Injury; Retinal Ganglion Cells	2009
[Cannabinoid applications in glaucoma]. Archivos de la Sociedad Espanola de Oftalmologia, 2011, Volume: 86, Issue:1 Topics: Animals; Arachidonic Acids; Benzoxazines; Cannabinoid Receptor Agonists; Cannabinoid Receptor Modulators; Cannabinoids; Drug Administration Routes; Drug Evaluation, Preclinical; Endocannabinoids; Excitatory Amino Acid Antagonists; Eye Proteins; Glaucoma; Glutamic Acid; Humans; Intraocular Pressure; Mammals; Morpholines; Naphthalenes; Neuroprotective Agents; Optic Nerve; Polyunsaturated Alkamides; Receptors, Cannabinoid; Retinal Ganglion Cells; Vasodilator Agents	2011
[The pathogenesis of retinal ganglia cell apoptosis induced by glaucoma]. [Zhonghua yan ke za zhi] Chinese journal of ophthalmology, 2004, Volume: 40, Issue:7 Topics: Apoptosis; Glaucoma; Glutamic Acid; Humans; Intraocular Pressure; Retinal Ganglion Cells	2004
Glial cells and glaucomatous neuropathy. Chinese medical journal, 2007, Feb-20, Volume: 120, Issue:4 Topics: Apoptosis; Extracellular Matrix Proteins; Glaucoma; Glutamic Acid; Humans; Neuroglia; Nitric Oxide Synthase; Optic Nerve; Optic Nerve Diseases; Retinal Ganglion Cells; Tumor Necrosis Factor-alpha	2007
[The excito-toxicity theory of glaucomatous neuropathy. General review]. Journal francais d'ophtalmologie, 1996, Volume: 19, Issue:1 Topics: Apoptosis; Glaucoma; Glutamic Acid; Humans; Neurons; Neurotransmitter Agents; Retina	1996
A proposed role for excitotoxicity in glaucoma. Journal of glaucoma, 1998, Volume: 7, Issue:1 Topics: Animals; Glaucoma; Glutamic Acid; Humans; N-Methylaspartate; Retinal Ganglion Cells; Vitreous Body	1998
Ganglion cell death in glaucoma: what do we really know? The British journal of ophthalmology, 1999, Volume: 83, Issue:8 Topics: Apoptosis; Axons; Cell Death; Ganglia, Sensory; Glaucoma; Glutamic Acid; Humans; Receptors, Cell Surface; Retinal Degeneration; Vitreous Body	1999
An experimental basis for implicating excitotoxicity in glaucomatous optic neuropathy. Survey of ophthalmology, 1999, Volume: 43 Suppl 1 Topics: Animals; Apoptosis; Enzyme Inhibitors; Glaucoma; Glutamic Acid; Humans; Intraocular Pressure; N-Methylaspartate; Neuroprotective Agents; Nitric Oxide Synthase; Optic Nerve Diseases; Retinal Ganglion Cells; Vitreous Body	1999
Saving the nerve from glaucoma: memantine to caspaces. Seminars in ophthalmology, 1999, Volume: 14, Issue:3 Topics: Animals; Apoptosis; Caspase Inhibitors; Caspases; Excitatory Amino Acid Antagonists; Glaucoma; Glutamic Acid; Humans; Memantine; Nitric Oxide Synthase; Optic Nerve Diseases; Retinal Ganglion Cells	1999
Neuroprotection: is it already applicable to glaucoma therapy? Current opinion in ophthalmology, 2000, Volume: 11, Issue:2 Topics: Animals; Apoptosis; Glaucoma; Glutamic Acid; Humans; Intraocular Pressure; Neuroprotective Agents; Nitric Oxide Synthase; Optic Nerve; Receptors, N-Methyl-D-Aspartate; Retinal Ganglion Cells	2000
Beyond intraocular pressure: neuroprotective strategies for future glaucoma therapy. Optometry and vision science : official publication of the American Academy of Optometry, 2001, Volume: 78, Issue:2 Topics: Animals; Apoptosis; Calcium Channel Blockers; Free Radicals; Glaucoma; Glutamic Acid; Humans; Nerve Growth Factors; Neuroprotective Agents; Nitric Oxide	2001

Other Studies

52 other study(ies) available for glutamic acid and Glaucoma

Article	Year
Effect of trans-resveratrol on glutamate clearance and visual behaviour in rats with glutamate induced retinal injury. Experimental eye research, 2022, Volume: 220 Topics: Amino Acid Transport System X-AG; Animals; Eye Injuries; Glaucoma; Glutamic Acid; Rats; Resveratrol; Retinal Diseases; Retinal Ganglion Cells	2022
Genetic inhibition of collapsin response mediator protein-2 phosphorylation ameliorates retinal ganglion cell death in normal-tension glaucoma models. Genes to cells : devoted to molecular & cellular mechanisms, 2022, Volume: 27, Issue:8 Topics: Animals; Disease Models, Animal; Glaucoma; Glutamic Acid; Intercellular Signaling Peptides and Proteins; Mice; N-Methylaspartate; Nerve Tissue Proteins; Phosphorylation; Retinal Ganglion Cells	2022
A Small Natural Molecule S3 Protects Retinal Ganglion Cells and Promotes Parkin-Mediated Mitophagy against Excitotoxicity. Molecules (Basel, Switzerland), 2022, Aug-04, Volume: 27, Issue:15 Topics: Glaucoma; Glutamic Acid; Humans; Mitochondrial Proteins; Mitophagy; Neuroprotective Agents; Neurotoxins; Optic Nerve Diseases; Retinal Ganglion Cells; Thiolester Hydrolases; Ubiquitin-Protein Ligases	2022
Dephosphorylation of ERK1/2 and DRP1 S585 regulates mitochondrial dynamics in glutamate toxicity of retinal neurons in vitro. Experimental eye research, 2022, Volume: 225 Topics: Animals; Dynamins; Glaucoma; Glutamic Acid; MAP Kinase Signaling System; Mitochondrial Dynamics; Rats; Retinal Neurons	2022
Role of CAST-Drp1 Pathway in Retinal Neuron-Regulated Necrosis in Experimental Glaucoma. Current medical science, 2023, Volume: 43, Issue:1 Topics: Animals; Calpain; Dynamins; Glaucoma; Glutamic Acid; Necrosis; Rats; Retinal Neurons	2023
GSK872 and necrostatin-1 protect retinal ganglion cells against necroptosis through inhibition of RIP1/RIP3/MLKL pathway in glutamate-induced retinal excitotoxic model of glaucoma. Journal of neuroinflammation, 2022, Oct-26, Volume: 19, Issue:1 Topics: Animals; Apoptosis; Caspase 1; Eosine Yellowish-(YS); Glaucoma; Glutamic Acid; Glutathione; Hematoxylin; Inflammasomes; Interleukin-1beta; Lactate Dehydrogenases; Mice; N-Methylaspartate; Necroptosis; NLR Family, Pyrin Domain-Containing 3 Protein; Reactive Oxygen Species; Receptor-Interacting Protein Serine-Threonine Kinases; Retinal Ganglion Cells	2022
The neuroprotective effect of melatonin in glutamate excitotoxicity of R28 cells and mouse retinal ganglion cells. Frontiers in endocrinology, 2022, Volume: 13 Topics: Animals; Glaucoma; Glutamic Acid; Melatonin; Mice; N-Methylaspartate; Neuroprotective Agents; Reactive Oxygen Species; Receptors, N-Methyl-D-Aspartate; Retinal Ganglion Cells	2022
Transplanted OECs Protect Visual Function by Regulating the Glutamate Metabolic Microenvironment in the Glaucoma Model. Journal of integrative neuroscience, 2023, May-06, Volume: 22, Issue:3 Topics: Animals; Apoptosis; Glaucoma; Glutamic Acid; Rats; Rats, Long-Evans; Retinal Ganglion Cells	2023
GABA decrease is associated with degraded neural specificity in the visual cortex of glaucoma patients. Communications biology, 2023, 06-29, Volume: 6, Issue:1 Topics: Aged; Cognition; gamma-Aminobutyric Acid; Glaucoma; Glutamic Acid; Humans; Neurodegenerative Diseases; Visual Cortex	2023
Effect of Adenosine and Adenosine Receptor Antagonists on Retinal Müller Cell Inwardly Rectifying Potassium Channels under Exogenous Glutamate Stimulation. BioMed research international, 2018, Volume: 2018 Topics: Adenosine; Animals; Ependymoglial Cells; Glaucoma; Glutamic Acid; Neuroglia; Potassium Channels, Inwardly Rectifying; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Retina	2018
Protective effects of a compound isolated from Alnus japonica on oxidative stress-induced death in transformed retinal ganglion cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2013, Volume: 56 Topics: Alnus; Animals; Apoptosis; Buthionine Sulfoximine; Catechols; Cell Survival; Diarylheptanoids; DNA Nucleotidylexotransferase; Glaucoma; Glutamic Acid; In Situ Nick-End Labeling; Lipid Peroxidation; Male; N-Methylaspartate; Neuroprotective Agents; Nitroprusside; Oxidative Stress; Plant Extracts; Propidium; Rats; Rats, Sprague-Dawley; Retina; Retinal Ganglion Cells; Thiobarbituric Acid Reactive Substances	2013
[Protective action of melatonin in experimental glaucoma in rats]. Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994), 2013, Volume: 59, Issue:1 Topics: Animals; Antioxidants; Aspartic Acid; Chromatography, Ion Exchange; Epinephrine; gamma-Aminobutyric Acid; Glaucoma; Glutamic Acid; Glycine; Intraocular Pressure; Male; Melatonin; Neuroprotective Agents; Neurotransmitter Agents; Rats; Retina; Vitreous Body	2013
Coenzyme Q10 inhibits glutamate excitotoxicity and oxidative stress-mediated mitochondrial alteration in a mouse model of glaucoma. Investigative ophthalmology & visual science, 2014, Feb-18, Volume: 55, Issue:2 Topics: Animals; Axons; bcl-Associated Death Protein; Blotting, Western; Disease Models, Animal; Female; Glaucoma; Glial Fibrillary Acidic Protein; Glutamic Acid; Heme Oxygenase-1; In Situ Nick-End Labeling; Membrane Proteins; Mice; Mice, Inbred DBA; Mitochondria; Nerve Tissue Proteins; Oxidative Stress; Real-Time Polymerase Chain Reaction; Receptors, N-Methyl-D-Aspartate; Retinal Degeneration; Retinal Ganglion Cells; Superoxide Dismutase; Ubiquinone; Vitamins	2014
[Homozygous E387K (1159G>A) mutation of the CYP1B1 gene in a Roma boy affected with primary congenital glaucoma. Case report]. Orvosi hetilap, 2014, Aug-17, Volume: 155, Issue:33 Topics: Aryl Hydrocarbon Hydroxylases; Child, Preschool; Cytochrome P-450 CYP1B1; Genetic Counseling; Glaucoma; Glutamic Acid; Humans; Hungary; Lysine; Male; Mutation; Roma; Slovakia	2014
Cumulative mtDNA damage and mutations contribute to the progressive loss of RGCs in a rat model of glaucoma. Neurobiology of disease, 2015, Volume: 74 Topics: Animals; Apoptosis; Axons; Cell Survival; Disease Models, Animal; Disease Progression; DNA Damage; DNA Repair; DNA, Mitochondrial; Glaucoma; Glutamic Acid; Intraocular Pressure; Male; Mitochondria; Mutation; Optic Nerve; Rats, Wistar; Retinal Ganglion Cells; Time Factors	2015
Increased mitochondrial fission and volume density by blocking glutamate excitotoxicity protect glaucomatous optic nerve head astrocytes. Glia, 2015, Volume: 63, Issue:5 Topics: Aged; Aged, 80 and over; Aldehyde Dehydrogenase; Animals; Astrocytes; Cell Count; Cells, Cultured; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Glaucoma; Glutamic Acid; Humans; Intraocular Pressure; Memantine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Middle Aged; Mitochondria; Mitochondrial Dynamics; N-Methylaspartate; Optic Disk; Oxidoreductases Acting on CH-NH Group Donors; Retinal Ganglion Cells	2015
Arundic acid attenuates retinal ganglion cell death by increasing glutamate/aspartate transporter expression in a model of normal tension glaucoma. Cell death & disease, 2015, Mar-19, Volume: 6 Topics: Animals; Caprylates; Cell Death; Excitatory Amino Acid Transporter 1; Gene Expression Regulation; Glaucoma; Glioblastoma; Glutamic Acid; Humans; Mice; Nerve Degeneration; Optic Nerve; Retinal Ganglion Cells	2015
α2-Adrenergic modulation of the glutamate receptor and transporter function in a chronic ocular hypertension model. European journal of pharmacology, 2015, Oct-15, Volume: 765 Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Biological Transport; Brimonidine Tartrate; Chronic Disease; Excitatory Amino Acid Transporter 1; Glaucoma; Glial Fibrillary Acidic Protein; Glutamic Acid; Intraocular Pressure; Male; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Glutamate	2015
Glaucoma as a neuropathy amenable to neuroprotection and immune manipulation. Progress in brain research, 2008, Volume: 173 Topics: Antigens; Calcium; Free Radicals; Glaucoma; Glutamic Acid; Humans; Intercellular Signaling Peptides and Proteins; Intraocular Pressure; Neuroprotective Agents; Optic Nerve Diseases; Oxidative Stress; Retinal Ganglion Cells; Risk Factors	2008
Rational basis for the development of coenzyme Q10 as a neurotherapeutic agent for retinal protection. Progress in brain research, 2008, Volume: 173 Topics: Animals; Calpain; Cell Death; Glaucoma; Glutamic Acid; Humans; Intraocular Pressure; Neuroprotective Agents; Oxidative Stress; Rats; Reperfusion Injury; Retina; Retinal Ganglion Cells; Ubiquinone	2008
17Beta-estradiol prevents retinal ganglion cell loss induced by acute rise of intraocular pressure in rat. Progress in brain research, 2008, Volume: 173 Topics: Animals; Cells, Cultured; Estradiol; Estrogen Antagonists; Estrogens; Fulvestrant; Glaucoma; Glutamic Acid; Intraocular Pressure; Male; Neurons; Rats; Rats, Wistar; Retinal Ganglion Cells	2008
GM-CSF regulates the ERK1/2 pathways and protects injured retinal ganglion cells from induced death. Experimental eye research, 2009, Volume: 89, Issue:5 Topics: Adult; Aged; Animals; Apoptosis; bcl-Associated Death Protein; Blotting, Western; Butadienes; Cells, Cultured; Disease Models, Animal; Glaucoma; Glutamic Acid; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Hydroxylamines; MAP Kinase Kinase Kinases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neuroanatomical Tract-Tracing Techniques; Nitriles; Nitro Compounds; Optic Nerve Injuries; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Retinal Ganglion Cells; Staurosporine	2009
Interleukin-1 attenuates normal tension glaucoma-like retinal degeneration in EAAC1-deficient mice. Neuroscience letters, 2009, Nov-13, Volume: 465, Issue:2 Topics: Animals; Cell Death; Cell Survival; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 3; Glaucoma; Glutamic Acid; Interleukin-1; Intracellular Space; Intraocular Pressure; Mice; Mice, Knockout; Neuroglia; Retina; Retinal Degeneration; Retinal Ganglion Cells; Sodium	2009
Melatonin: a novel neuroprotectant for the treatment of glaucoma. Journal of pineal research, 2010, Volume: 48, Issue:4 Topics: Animals; Arginine; gamma-Aminobutyric Acid; Glaucoma; Glutamate Decarboxylase; Glutamic Acid; Histocytochemistry; Intraocular Pressure; Kinetics; Male; Melatonin; Neuroprotective Agents; Nitric Oxide Synthase; Oxidative Stress; Rats; Rats, Wistar; Retina; Retinal Ganglion Cells	2010
Advances in glaucoma treatment and management: neurotrophic agents. Investigative ophthalmology & visual science, 2012, May-04, Volume: 53, Issue:5 Topics: Animals; Antioxidants; Apoptosis; Calcium Channel Blockers; Free Radicals; Glaucoma; Gliosis; Glutamic Acid; Humans; Nerve Growth Factors; Neuroprotective Agents; Nitric Oxide	2012
Ectopic vesicular glutamate release at the optic nerve head and axon loss in mouse experimental glaucoma. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012, Nov-07, Volume: 32, Issue:45 Topics: Animals; Axons; Disease Models, Animal; Exocytosis; Glaucoma; Glutamic Acid; Intraocular Pressure; Mice; Optic Disk; Retinal Ganglion Cells; Secretory Vesicles; Synapses; Synaptophysin; Vesicular Glutamate Transport Protein 2	2012
Effect of nafamostat on N-methyl-D-aspartate-induced retinal neuronal and capillary degeneration in rats. Biological & pharmaceutical bulletin, 2012, Volume: 35, Issue:12 Topics: Animals; Basement Membrane; Benzamidines; Capillaries; Diabetic Neuropathies; Excitatory Amino Acid Agonists; Glaucoma; Glutamic Acid; Guanidines; Intravitreal Injections; Male; N-Methylaspartate; Nerve Degeneration; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Retina; Retinal Diseases; Retinal Ganglion Cells; Retinal Neurons; Retinal Vessels; Serine Proteinase Inhibitors; Severity of Illness Index; Vascular Diseases	2012
Protective effects of timolol against the neuronal damage induced by glutamate and ischemia in the rat retina. Brain research, 2002, Dec-20, Volume: 958, Issue:1 Topics: Action Potentials; Acute Disease; Animals; Cell Death; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Electroretinography; Excitatory Amino Acid Antagonists; Fetus; Glaucoma; Glutamic Acid; Hypoxia-Ischemia, Brain; Neuroprotective Agents; Rats; Rats, Wistar; Reperfusion Injury; Retinal Degeneration; Retinal Ganglion Cells; Timolol	2002
Glutamate stimulates neurotrophin expression in cultured Müller cells. Brain research. Molecular brain research, 2003, Mar-17, Volume: 111, Issue:1-2 Topics: Amino Acid Transport System X-AG; Animals; Brain-Derived Neurotrophic Factor; Cells, Cultured; Glaucoma; Glial Cell Line-Derived Neurotrophic Factor; Glutamic Acid; Models, Biological; Nerve Growth Factor; Nerve Growth Factors; Neuroglia; Neurotoxins; Neurotrophin 3; Rats; Rats, Sprague-Dawley; Receptor, trkB; Receptors, Glutamate; Retina; Tetrazolium Salts; Up-Regulation	2003
Effects of commercial antiglaucoma drugs to glutamate-induced [Ca2+)]i increase in cultured neuroblastoma cells. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2003, Volume: 19, Issue:3 Topics: Animals; Antihypertensive Agents; Betaxolol; Brimonidine Tartrate; Calcium; Carteolol; Cell Death; Dose-Response Relationship, Drug; Epinephrine; Glaucoma; Glutamic Acid; Latanoprost; Mice; Neuroblastoma; Neurons; Neuroprotective Agents; Pilocarpine; Prostaglandins F, Synthetic; Quinoxalines; Sulfonamides; Thiazines; Thiophenes; Timolol; Tumor Cells, Cultured	2003
Purification of a neuroprotective component of Parawixia bistriata spider venom that enhances glutamate uptake. British journal of pharmacology, 2003, Volume: 139, Issue:7 Topics: Animals; Brazil; Carbon Isotopes; Cerebral Cortex; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Disease Models, Animal; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Glaucoma; Glutamic Acid; Ion Channels; Male; Neuroprotective Agents; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Retina; Spider Venoms; Spiders; Synaptosomes; Tissue Extracts; Tritium	2003
Müller cell response to laser-induced increase in intraocular pressure in rats. Glia, 2004, Aug-01, Volume: 47, Issue:2 Topics: Amino Acid Transport System X-AG; Animals; Cell Count; Disease Models, Animal; Down-Regulation; Glaucoma; Glial Fibrillary Acidic Protein; Glutamate-Ammonia Ligase; Glutamic Acid; Homeostasis; Intraocular Pressure; Lasers; Male; Neuroglia; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Wistar; Reaction Time; Retina; Retinal Degeneration; Retinal Ganglion Cells	2004
Evaluation of glutamate loss from damaged retinal cells of dogs with primary glaucoma. American journal of veterinary research, 2004, Volume: 65, Issue:6 Topics: Analysis of Variance; Animals; Dog Diseases; Dogs; Glaucoma; Glutamic Acid; Immunohistochemistry; In Situ Nick-End Labeling; Retina	2004
Efficacy and safety of memantine treatment for reduction of changes associated with experimental glaucoma in monkey, I: Functional measures. Investigative ophthalmology & visual science, 2004, Volume: 45, Issue:8 Topics: Administration, Oral; Animals; Cell Count; Chronic Disease; Disease Models, Animal; Electroretinography; Evoked Potentials, Visual; Excitatory Amino Acid Antagonists; Glaucoma; Glutamic Acid; Intraocular Pressure; Macaca fascicularis; Memantine; Ocular Hypertension; Optic Nerve Diseases; Retina; Retinal Ganglion Cells; Safety; Treatment Outcome; Vitreous Body	2004
Vitreous glutamate concentration and axon loss in monkeys with experimental glaucoma. Archives of ophthalmology (Chicago, Ill. : 1960), 2005, Volume: 123, Issue:1 Topics: Animals; Axons; Cell Count; Chromatography, High Pressure Liquid; Chronic Disease; Disease Models, Animal; Female; Glaucoma; Glutamic Acid; Intraocular Pressure; Laser Therapy; Macaca fascicularis; Macaca mulatta; Male; Optic Nerve; Optic Nerve Diseases; Trabecular Meshwork; Vitreous Body	2005
Glutamate excitotoxicity in glaucoma: truth or fiction? Eye (London, England), 2005, Volume: 19, Issue:4 Topics: Animals; Glaucoma; Glutamic Acid; Haplorhini; Humans; Mice; Receptors, N-Methyl-D-Aspartate; Retinal Artery Occlusion; Retinal Ganglion Cells	2005
Effect of glaucoma on the retinal glutamate/glutamine cycle activity. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2005, Volume: 19, Issue:9 Topics: Animals; Glaucoma; Glutamate-Ammonia Ligase; Glutamic Acid; Glutaminase; Glutamine; Hyaluronic Acid; Intraocular Pressure; Male; Melatonin; Rats; Rats, Wistar; Retina	2005
Depletion of taurine and glutamate from damaged photoreceptors in the retinas of dogs with primary glaucoma. American journal of veterinary research, 2005, Volume: 66, Issue:5 Topics: Animals; Dog Diseases; Dogs; Glaucoma; Glutamic Acid; Photoreceptor Cells; Retina; Taurine	2005
Glutamate excitotoxicity in glaucoma: throwing the baby out with the bathwater? Eye (London, England), 2006, Volume: 20, Issue:6 Topics: Glaucoma; Glutamic Acid; Humans; Receptors, N-Methyl-D-Aspartate; Vitreous Body	2006
Functional assessment of glutamate clearance mechanisms in a chronic rat glaucoma model using retinal ganglion cell calcium imaging. Journal of neurochemistry, 2005, Volume: 94, Issue:3 Topics: Animals; Animals, Newborn; Aspartic Acid; Calcium; Cells, Cultured; Diagnostic Imaging; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Fura-2; Glaucoma; Glutamic Acid; In Vitro Techniques; Intraocular Pressure; Male; N-Methylaspartate; Optic Nerve; Rats; Rats, Long-Evans; Retina; Retinal Ganglion Cells; Time Factors	2005
Glutamate level in optic nerve head is increased by artificial elevation of intraocular pressure in rabbits. Experimental eye research, 2006, Volume: 82, Issue:3 Topics: Animals; Chromatography, High Pressure Liquid; Disease Models, Animal; Glaucoma; Glutamic Acid; Microdialysis; Ocular Hypertension; Optic Disk; Rabbits	2006
Assessment of neuroprotective effects of glutamate modulation on glaucoma-related retinal ganglion cell apoptosis in vivo. Investigative ophthalmology & visual science, 2006, Volume: 47, Issue:2 Topics: Animals; Apoptosis; Bridged Bicyclo Compounds; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Therapy, Combination; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glaucoma; Glutamic Acid; Intraocular Pressure; Male; Neuroprotective Agents; Ocular Hypertension; Piperidines; Rats; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Retinal Ganglion Cells; Staurosporine	2006
Assessment of glutamate loss from the ganglion cell layer of young DBA/2J mice with glaucoma. American journal of veterinary research, 2006, Volume: 67, Issue:2 Topics: Aging; Animals; Glaucoma; Glutamic Acid; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Retinal Ganglion Cells	2006
Evoked expression of the glutamate transporter GLT-1c in retinal ganglion cells in human glaucoma and in a rat model. Investigative ophthalmology & visual science, 2006, Volume: 47, Issue:9 Topics: Aged; Aged, 80 and over; Animals; Disease Models, Animal; Excitatory Amino Acid Transporter 2; Female; Glaucoma; Glutamic Acid; Humans; Immunoenzyme Techniques; Intraocular Pressure; Male; Photoreceptor Cells, Vertebrate; Rats; Rats, Inbred BN; Retinal Ganglion Cells	2006
Aloe-emodin metabolites protected N-methyl-d-aspartate-treated retinal ganglion cells by Cu-Zn superoxide dismutase. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2007, Volume: 23, Issue:2 Topics: Animals; Anthraquinones; Apoptosis; Chromatography, Liquid; Electrophoresis, Gel, Two-Dimensional; Emodin; Enzyme Inhibitors; Gene Expression Regulation; Glaucoma; Glucuronides; Glutamic Acid; N-Methylaspartate; Neuroprotective Agents; Polymerase Chain Reaction; Protein Processing, Post-Translational; Rats; Receptors, N-Methyl-D-Aspartate; Retinal Ganglion Cells; RNA, Messenger; Spectrometry, Mass, Electrospray Ionization; Sulfates; Superoxide Dismutase; Transcription, Genetic	2007
The potential role of glutamate transporters in the pathogenesis of normal tension glaucoma. The Journal of clinical investigation, 2007, Volume: 117, Issue:7 Topics: Amino Acid Transport System X-AG; Animals; Disease Models, Animal; Gene Expression Regulation; Glaucoma; Glutamic Acid; Intraocular Pressure; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutation; Nerve Degeneration; Optic Nerve Diseases; Oxidative Stress; Retinal Ganglion Cells; Vision, Ocular	2007
Neuroprotection of muscarinic receptor agonist pilocarpine against glutamate-induced apoptosis in retinal neurons. Cellular and molecular neurobiology, 2008, Volume: 28, Issue:2 Topics: Animals; Apoptosis; Calcium; Caspase 3; Cell Survival; Cells, Cultured; Gene Expression; Glaucoma; Glutamic Acid; Homeostasis; Membrane Potential, Mitochondrial; Muscarinic Agonists; Neuroprotective Agents; Pilocarpine; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Retinal Ganglion Cells	2008
Elevated glutamate levels in the vitreous body of humans and monkeys with glaucoma. Archives of ophthalmology (Chicago, Ill. : 1960), 1996, Volume: 114, Issue:3 Topics: Aged; Amino Acids; Animals; Aqueous Humor; Cataract; Cataract Extraction; Disease Models, Animal; Female; Glaucoma; Glutamic Acid; Humans; Macaca fascicularis; Male; Prospective Studies; Rats; Retrospective Studies; Vitrectomy; Vitreous Body	1996
Retinal vulnerability to glutamate excitotoxicity in canine glaucoma: induction of neuronal nitric oxide synthase in retinal ganglion cells. Proceedings of the Western Pharmacology Society, 1998, Volume: 41 Topics: Animals; Dogs; Glaucoma; Glutamic Acid; Nitric Oxide Synthase; Retinal Ganglion Cells; Vitreous Body	1998
Characterization of a transformed rat retinal ganglion cell line. Brain research. Molecular brain research, 2001, Jan-31, Volume: 86, Issue:1-2 Topics: Animals; Animals, Newborn; Antibodies, Monoclonal; Antigens, Surface; Apoptosis; Biomarkers; Brain-Derived Neurotrophic Factor; Cell Culture Techniques; Cell Differentiation; Cell Line, Transformed; Culture Media, Serum-Free; DNA-Binding Proteins; Glaucoma; Glial Fibrillary Acidic Protein; Glutamic Acid; GPI-Linked Proteins; In Situ Nick-End Labeling; Nerve Growth Factors; Nerve Tissue Proteins; Neuropeptides; Neuroprotective Agents; Rats; Receptors, GABA-B; Retinal Ganglion Cells; Synaptophysin; Syntaxin 1; Thy-1 Antigens; Transcription Factor Brn-3; Transcription Factor Brn-3C; Transcription Factors	2001
Vaccination for protection of retinal ganglion cells against death from glutamate cytotoxicity and ocular hypertension: implications for glaucoma. Proceedings of the National Academy of Sciences of the United States of America, 2001, Mar-13, Volume: 98, Issue:6 Topics: Adjuvants, Immunologic; Adoptive Transfer; Amino Acid Sequence; Animals; Cell Death; Glatiramer Acetate; Glaucoma; Glutamic Acid; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Molecular Sequence Data; Myelin Basic Protein; Myelin Proteins; Myelin-Associated Glycoprotein; Myelin-Oligodendrocyte Glycoprotein; Ocular Hypertension; Peptides; Rats; Rats, Inbred Lew; Retinal Ganglion Cells; T-Lymphocytes; Vaccination	2001
Private investigations. Nature, 2001, May-10, Volume: 411, Issue:6834 Topics: Animals; Chromatography, High Pressure Liquid; Clinical Trials as Topic; Confidentiality; Glaucoma; Glutamic Acid; Guinea Pigs; Haplorhini; Humans; Massachusetts; Memantine; Meniere Disease; National Institutes of Health (U.S.); Neurosciences; Pennsylvania; Research; Scientific Misconduct; United States; United States Food and Drug Administration; United States Office of Research Integrity	2001