Compounds > glutamic acid

glutamic acid and Fra(X) Syndrome

glutamic acid has been researched along with Fra(X) Syndrome in 21 studies

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's6 (28.57)29.6817
2010's14 (66.67)24.3611
2020's1 (4.76)2.80

Authors

AuthorsStudies
Booker, SA; Domanski, APF; Isaac, JTR; Kind, PC; Wyllie, DJA1
Booker, SA; Dando, OR; Domanski, APF; Hardingham, GE; Isaac, JTR; Jackson, AD; Kind, PC; Wyllie, DJA1
Gray, JA; Hagerman, RH; Kutas, M; Li, W; Olichney, JM1
Huntsman, MM; Klug, A; McCullagh, EA; Salcedo, E1
Achuta, VS; Castrén, ML; Keinänen, K; Möykkynen, T; Peteri, UK; Rivera, C; Turconi, G1
García-Font, N; Martín, R; Oset-Gasque, MJ; Sánchez-Prieto, J; Torres, M1
Cao, Z; Cui, Y; Hagerman, PJ; Hulsizer, S; Kim, KH; Pessah, IN; Pretto, DL; Tassone, F1
Davenport, MH; Erickson, CA; Fitzpatrick, SE; Friedmann, KJ; Schaefer, TL1
Brandon, NJ; Chadchankar, J; Deeb, TZ; Dunlop, J; Hyde, TM; Kang, JY; Mather, RJ; Mighdoll, MI; Moss, SJ; Pangalos, MN; Vien, TN1
Castrén, E; Castrén, ML; Hokkanen, ME; Kratochwil, CF; Louhivuori, V; Sun, X; Tervonen, TA; Zebryk, P1
Lombroso, P; Ogren, M1
Malter, JS; Ray, BC; Westmark, CJ; Westmark, PR1
Adusei, DC; Hampson, DR; Pacey, LK1
Irwin, SA1
Crespo, M; Cruz-Martín, A; Portera-Cailliau, C1
Harrison, C1
Dulla, C; Freeman, M; Higashimori, H; Huth, J; Lindemann, L; Morel, L; Taylor, A; Yang, Y1
Bassell, GJ; Gross, C1
Bray, SM; Chang, S; He, C; Jin, P; Li, Z; Warren, ST; Zarnescu, DC1
Braun, K; Gruss, M1

Reviews

3 review(s) available for glutamic acid and Fra(X) Syndrome

ArticleYear
The Role of Glutamate in Language and Language Disorders - Evidence from ERP and Pharmacologic Studies.
    Neuroscience and biobehavioral reviews, 2020, Volume: 119

    Topics: Aphasia; Fragile X Syndrome; Glutamic Acid; Humans; Language; Tremor

2020
Pharmacotherapy for Fragile X Syndrome: Progress to Date.
    Drugs, 2016, Volume: 76, Issue:4

    Topics: Animals; Brain; Clinical Trials as Topic; Fragile X Mental Retardation Protein; Fragile X Syndrome; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Signal Transduction

2016
Fragile X Syndrome and Alzheimer's Disease: Another story about APP and beta-amyloid.
    Current Alzheimer research, 2010, Volume: 7, Issue:3

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Disease Models, Animal; Excitatory Amino Acid Antagonists; Fragile X Mental Retardation Protein; Fragile X Syndrome; Glutamic Acid; Humans; Phenotype; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate

2010

Other Studies

18 other study(ies) available for glutamic acid and Fra(X) Syndrome

ArticleYear
Cellular and synaptic phenotypes lead to disrupted information processing in Fmr1-KO mouse layer 4 barrel cortex.
    Nature communications, 2019, 10-23, Volume: 10, Issue:1

    Topics: Action Potentials; Animals; Computer Simulation; Disease Models, Animal; Fragile X Mental Retardation Protein; Fragile X Syndrome; Glutamic Acid; Male; Mice; Mice, Knockout; Neurons; Patch-Clamp Techniques; Phenotype; Somatosensory Cortex; Synapses

2019
Altered dendritic spine function and integration in a mouse model of fragile X syndrome.
    Nature communications, 2019, 10-23, Volume: 10, Issue:1

    Topics: Action Potentials; Animals; Dendritic Spines; Disease Models, Animal; Fragile X Mental Retardation Protein; Fragile X Syndrome; Glutamic Acid; Male; Mice; Mice, Knockout; Neurogenesis; Neurons; Patch-Clamp Techniques; Somatosensory Cortex; Synapses

2019
Tonotopic alterations in inhibitory input to the medial nucleus of the trapezoid body in a mouse model of Fragile X syndrome.
    The Journal of comparative neurology, 2017, Nov-01, Volume: 525, Issue:16

    Topics: Animals; Auditory Pathways; Disease Models, Animal; Female; Fragile X Mental Retardation Protein; Fragile X Syndrome; Gene Expression Regulation; Glutamate Decarboxylase; Glutamic Acid; Glycine; Glycine Plasma Membrane Transport Proteins; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neural Inhibition; Neurons; Sound Localization; Trapezoid Body; Vesicular Glutamate Transport Protein 2

2017
Functional changes of AMPA responses in human induced pluripotent stem cell-derived neural progenitors in fragile X syndrome.
    Science signaling, 2018, 01-16, Volume: 11, Issue:513

    Topics: Animals; Calcium; Cell Differentiation; Cells, Cultured; Female; Fragile X Mental Retardation Protein; Fragile X Syndrome; Glutamic Acid; Humans; Induced Pluripotent Stem Cells; Male; Mice; Mice, Knockout; Neurons; Receptors, AMPA

2018
The loss of β adrenergic receptor mediated release potentiation in a mouse model of fragile X syndrome.
    Neurobiology of disease, 2019, Volume: 130

    Topics: Animals; Cerebral Cortex; Disease Models, Animal; Fragile X Mental Retardation Protein; Fragile X Syndrome; Glutamic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, Adrenergic, beta; Synaptic Transmission; Synaptic Vesicles; Synaptosomes

2019
Enhanced asynchronous Ca(2+) oscillations associated with impaired glutamate transport in cortical astrocytes expressing Fmr1 gene premutation expansion.
    The Journal of biological chemistry, 2013, May-10, Volume: 288, Issue:19

    Topics: Animals; Astrocytes; Ataxia; Biological Transport; Calcium Signaling; Cells, Cultured; Cerebral Cortex; Dicarboxylic Acids; Excitatory Amino Acid Agonists; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Female; Fragile X Mental Retardation Protein; Fragile X Syndrome; Glutamic Acid; Kinetics; Male; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neurotransmitter Uptake Inhibitors; Pyrrolidines; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Tremor; Trinucleotide Repeat Expansion

2013
Deficits in the activity of presynaptic γ-aminobutyric acid type B receptors contribute to altered neuronal excitability in fragile X syndrome.
    The Journal of biological chemistry, 2017, 04-21, Volume: 292, Issue:16

    Topics: Aged; Aged, 80 and over; Animals; Behavior, Animal; Disease Models, Animal; Fragile X Mental Retardation Protein; Fragile X Syndrome; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Phosphorylation; Receptors, GABA-B; RNA, Messenger; Serine; Signal Transduction; Synaptic Transmission

2017
Aberrant differentiation of glutamatergic cells in neocortex of mouse model for fragile X syndrome.
    Neurobiology of disease, 2009, Volume: 33, Issue:2

    Topics: Animals; Animals, Newborn; Cell Differentiation; Cell Lineage; Disease Models, Animal; DNA-Binding Proteins; Excitatory Amino Acid Transporter 1; Fatty Acid-Binding Protein 7; Fatty Acid-Binding Proteins; Fragile X Mental Retardation Protein; Fragile X Syndrome; Glutamic Acid; Mesenchymal Stem Cells; Mice; Mice, Knockout; Mutation; Neocortex; Nerve Tissue Proteins; Neurogenesis; Neurons; Pyramidal Cells; Stem Cells; T-Box Domain Proteins

2009
Learning and memory, part II: molecular mechanisms of synaptic plasticity.
    Journal of the American Academy of Child and Adolescent Psychiatry, 2009, Volume: 48, Issue:1

    Topics: Amygdala; Animals; Axons; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Conditioning, Classical; Extracellular Signal-Regulated MAP Kinases; Fear; Fragile X Syndrome; Glutamic Acid; Hippocampus; Humans; Learning; Long-Term Potentiation; Memory; Mice; Neuronal Plasticity; Neurons; Perforant Pathway; Protein Tyrosine Phosphatases; Protein Tyrosine Phosphatases, Non-Receptor; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Second Messenger Systems

2009
Rare diseases offer insights into autism spectrum disorders. Preliminary laboratory studies suggest new biological targets for intervention.
    The Harvard mental health letter, 2009, Volume: 25, Issue:10

    Topics: Animals; Autistic Disorder; Drosophila; Fragile X Mental Retardation Protein; Fragile X Syndrome; Glutamic Acid; Humans; Immunosuppressive Agents; Methyl-CpG-Binding Protein 2; Mice; Protein Kinases; Rett Syndrome; Sirolimus; TOR Serine-Threonine Kinases; Tuberous Sclerosis; Tuberous Sclerosis Complex 1 Protein; Tuberous Sclerosis Complex 2 Protein; Tumor Suppressor Proteins

2009
The neurochemical basis for the treatment of autism spectrum disorders and Fragile X Syndrome.
    Biochemical pharmacology, 2011, May-01, Volume: 81, Issue:9

    Topics: Animals; Autistic Disorder; Disease Models, Animal; Fragile X Syndrome; gamma-Aminobutyric Acid; Glutamic Acid; Humans

2011
The role of glutamate in my professional life: from molecular neuroplasticity to the relief of suffering.
    Developmental psychobiology, 2011, Volume: 53, Issue:5

    Topics: Animals; Fragile X Mental Retardation Protein; Fragile X Syndrome; Glutamic Acid; Humans; Neuronal Plasticity; Palliative Care; Receptors, Metabotropic Glutamate; Stress, Psychological

2011
Glutamate induces the elongation of early dendritic protrusions via mGluRs in wild type mice, but not in fragile X mice.
    PloS one, 2012, Volume: 7, Issue:2

    Topics: Animals; Brain; Dendrites; Disease Models, Animal; Electroporation; Fragile X Mental Retardation Protein; Fragile X Syndrome; Genotype; Glutamic Acid; Green Fluorescent Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Fluorescence; Models, Genetic; Photons; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate

2012
Deal watch: Roche deal targets glutamate in neurodevelopmental disorders.
    Nature reviews. Drug discovery, 2012, Volume: 11, Issue:8

    Topics: Child; Child Development Disorders, Pervasive; Cooperative Behavior; Drug Delivery Systems; Drug Design; Drug Industry; Excitatory Amino Acid Antagonists; Fragile X Syndrome; GABA-B Receptor Agonists; Glutamic Acid; Humans; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate

2012
Astroglial FMRP-dependent translational down-regulation of mGluR5 underlies glutamate transporter GLT1 dysregulation in the fragile X mouse.
    Human molecular genetics, 2013, May-15, Volume: 22, Issue:10

    Topics: Animals; Astrocytes; Cerebral Cortex; Down-Regulation; Excitatory Amino Acid Transporter 2; Fragile X Mental Retardation Protein; Fragile X Syndrome; Gene Knockdown Techniques; Glutamic Acid; Humans; Kainic Acid; Mice; Neurons; Protein Biosynthesis; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate

2013
Reducing glutamate signaling pays off in fragile X.
    Nature medicine, 2008, Volume: 14, Issue:3

    Topics: Animals; Anticonvulsants; Fragile X Syndrome; Glutamic Acid; Mice; Receptors, Metabotropic Glutamate; Signal Transduction

2008
Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila.
    Nature chemical biology, 2008, Volume: 4, Issue:4

    Topics: Animals; Disease Models, Animal; Drosophila; Drosophila Proteins; Drug Evaluation, Preclinical; Female; Fragile X Mental Retardation Protein; Fragile X Syndrome; gamma-Aminobutyric Acid; Glutamic Acid; Male; Molecular Weight; Mutation; Phenotype; Pyridines; RNA, Messenger; Small Molecule Libraries

2008
Alterations of amino acids and monoamine metabolism in male Fmr1 knockout mice: a putative animal model of the human fragile X mental retardation syndrome.
    Neural plasticity, 2001, Volume: 8, Issue:4

    Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Alanine; Amino Acids; Animals; Aspartic Acid; Brain; Brain Stem; Cerebellum; Cerebral Cortex; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; Fragile X Mental Retardation Protein; Fragile X Syndrome; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Hippocampus; Homovanillic Acid; Hydroxyindoleacetic Acid; Intellectual Disability; Male; Mice; Mice, Knockout; Models, Animal; Nerve Tissue Proteins; RNA-Binding Proteins; Serotonin; Taurine; Thalamus

2001