glutamic acid has been researched along with Encephalopathy, Toxic in 125 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (0.80) | 18.7374 |
| 1990's | 1 (0.80) | 18.2507 |
| 2000's | 39 (31.20) | 29.6817 |
| 2010's | 68 (54.40) | 24.3611 |
| 2020's | 16 (12.80) | 2.80 |
| Authors | Studies |
|---|---|
| Ge, L; Lazarovici, P; Liu, S; Rubin, L; Zheng, W | 1 |
| Azami Tameh, A; Karimian, M; Khassafi, N; Vahidinia, Z; Zahraei, Z | 1 |
| Bernath, AK; Klegeris, A; Lindhout, IA; Murray, TE; Richards, CM; Robert-Gostlin, VN | 1 |
| Boyko, M; Fleidervish, I; Frenkel, A; Gruenbaum, BF; Zlotnik, A | 1 |
| Baek, SJ; Charoenkiatkul, S; Nantacharoen, W; Plaingam, W; Sukprasansap, M; Tencomnao, T | 1 |
| Chern, CJ; Chern, CR; Chodounská, H; Kudová, E; Lauková, M; Schonwald, A; Shakarjian, MP; Velíšek, L; Velíšková, J | 1 |
| Chen, H; Dang, Y; Li, H; Tan, S; Xiang, M; Xie, D; Yang, Y; Yu, Y | 1 |
| Holton, KF; Martami, F | 1 |
| Akaike, A; Izumi, Y; Kume, T; Taguchi, K; Takada-Takatori, Y | 1 |
| Gong, W; Qin, X; Zhou, Y | 1 |
| Deng, Y; Liu, W; Xu, B; Xu, Z; Yang, T | 1 |
| Chen, Y; Hall, FS; Saber, YH; Tran, HTN | 1 |
| Guo, L; Hong, J; Liu, X; Pfaff, D; Shi, M; Tang, H; Wang, Y; Zhao, X | 1 |
| Andrade, PB; Neves, D; Rocha, L; Valentão, P; Videira, RA | 1 |
| Holton, KF; Joyce, MR | 1 |
| Cauli, B; Hérault, K; Li, D; Maldera, S; Oheim, M; Pham, C; Vialou, V | 1 |
| Chanvorachote, P; Sukprasansap, M; Tencomnao, T | 1 |
| Cao, X; Chen, C; Cheng, S; Jiang, X; Li, C; Qin, Q; Su, Q; Tu, B; Wang, J; Xia, Y; Yang, K | 1 |
| Downing, S; Downing, TG; Scott, LL | 1 |
| Cattani, D; Cesconetto, PA; De Oliveira, PA; Filho, DW; Leite, MC; Parisotto, EB; Prediger, RDS; Razzera, G; Rieg, CEH; Tavares, MK; Wendt, NC; Zamoner, A | 1 |
| Ishida, K; Kotake, Y; Miyara, M; Ohta, S; Sanoh, S; Umeda, K | 1 |
| Furuta, K; Hirata, Y; Kiuchi, K; Oh-Hashi, K; Shibata, S; Ueda, H | 1 |
| Ausseil, J; Cleren, C; Daher, I; Daumas, S; Dourmap, N; El Mestikawy, S; Gomila, C; Gonzalez, B; Le Dieu-Lugon, B; Lecuyer, M; Leroux, P; Leroux-Nicollet, I; Marret, S; Ramet, L; Roy, V | 1 |
| Chiosi, F; Costagliola, C; Davinelli, S; Di Marco, R; Scapagnini, G | 1 |
| Ham, SA; Han, SG; Hong, K; Hwang, JS; Lee, CH; Lee, WJ; Lim, DS; Paek, KS; Seo, HG; Yoo, H; Yoo, T | 1 |
| Górska, A; Gołembiowska, K; Kajta, M; Kamińska, K; Kreiner, G; Noworyta-Sokołowska, K; Rzemieniec, J; Wnuk, A; Wojtas, A | 1 |
| Lockridge, O; Schopfer, LM | 1 |
| Hsieh, HL; Hsieh, TY; Huang, SK; Lin, TY; Lu, CW; Wang, SJ | 1 |
| Barg-Hock, H; Beneke, J; Ding, XQ; Jäckel, E; Klempnauer, J; Lanfermann, H; Pflugrad, H; Schmitz, B; Schrem, H; Tryc, AB; Weissenborn, K | 1 |
| Cheng, J; Jiang, Y; Li, Y; Tang, Z; Xu, S; Zhang, J | 1 |
| Chi, T; Ji, X; Li, Y; Liu, D; Liu, H; Liu, P; Qi, X; Xu, J; Zou, L | 1 |
| Diwan, PV; Kakalij, RM; Prasad, VV; Singh, HJ; Syeda, TU | 1 |
| Afanador, L; Angulo, JA; Baker, L; Diaz, C; Mexhitaj, I; Ordonez, D | 1 |
| Aschner, M; Sidoryk-Wegrzynowicz, M | 1 |
| Blaber, M; Blaber, SI; Fehlings, MG; Radulovic, M; Scarisbrick, IA; Wu, J; Yoon, H | 1 |
| Hassani, S; Khanavi, M; Ostad, SN; Sabzevari, O; Tavakoli, F; Tayeboon, GS | 1 |
| Shi, HB; Ye, HB; Yin, SK | 1 |
| Jain, MR; Levison, SW; Li, H; Simonishvili, S; Wood, TL | 1 |
| Álvarez, J; Baluja, A; Blanco, M; Campos, F; Castillo, J; López-Arias, E; Sobrino, T | 1 |
| Jin, Y; Li, C; Liu, W; Wang, F | 1 |
| Cattani, D; Dal-Cim, T; de Liz Oliveira Cavalli, VL; Domingues, JT; Heinz Rieg, CE; Mena Barreto Silva, FR; Tasca, CI; Zamoner, A | 1 |
| An, L; Cao, D; Chen, N; Liu, L; Yang, J; Zhao, Y; Zhu, C | 1 |
| Bertoldo, DB; Dal-Cim, T; Maraschin, M; Martins, WC; Tasca, CI; Vandresen-Filho, S; Zeni, AL | 1 |
| Dowben, JS; Keltner, NL; Kowalski, PC | 1 |
| da Costa, FL; de Oliveira, AC; Gomez, MV; Gomez, RS; Lima, IV; Mendes-Goulart, VA; Pinto, MC; Resende, RR; Romano-Silva, MA; Rosa, DV | 1 |
| Deng, Y; Feng, S; Li, YH; Liu, W; Xu, B; Xu, ZF; Yang, TY | 1 |
| Bradfield, SM; Geller, T; Krischer, JP; Sandler, E; Tamura, RN | 1 |
| Cortopassi, GA; Erickson, JD; Horiuchi, M; Jin, LW; Liu, XB; Maezawa, I; Wulff, H | 1 |
| Antal, EA; Dahlberg, D; Goverud, IL; Hassel, B; Mariussen, E; Mæhlen, J; Tønjum, T | 1 |
| Chen, Q; Ding, W; Huang, Y; Liu, F; Rui, W; Wu, B; Zhang, F; Zheng, JC | 1 |
| Barrese, V; Davidson, C; Greenwood, IA; Taglialatela, M | 1 |
| Chang, CY; Chou, SS; Huang, SK; Lin, TY; Lu, CW; Wang, SJ; Wang, YC | 1 |
| Ang, S; He, K; Tang, M; Wu, T; Xue, Y; Ying, J; Zhan, Q; Zhang, S; Zhang, T | 1 |
| Antipova, TA; Gudasheva, TA; Kolyasnikova, KN; Nikolaev, SV; Povarnina, PY | 1 |
| Abd El-Hamid, DH; Abdel-Rahman, MS; Abdel-Zaher, AO; Hamdy, MM | 1 |
| Candelario-Jalil, E; de Oliveira, AC; Fiebich, BL; Saliba, SW; Santos, RP; Teixeira, AL; Vieira, EL; Vieira, LB | 1 |
| Chung, IM; Kim, MY; Moon, HI; Park, WH | 1 |
| An, RB; Chung, HT; Jeong, GS; Kang, DG; Kim, YC; Lee, HS; Pae, HO; Yoon, KH | 1 |
| Blank, T; Dolga, AM; Eisel, UL; Granic, I; Knaus, HG; Luiten, PG; Nijholt, IM; Spiess, J | 1 |
| Jang, S; Jung, JC; Jung, M; Kim, DH; Lee, Y; Oh, S; Ryu, JH | 1 |
| Ander, BP; Liu, DZ; Sharp, F; Zhan, X | 1 |
| Basu, N; Gong, P; Perkins, EJ; Scheuhammer, AM | 1 |
| Dai, H; Shi, Y; Xu, X | 1 |
| Chen, X; Ding, F; Gu, X; Zhou, S | 1 |
| Andras, M; Dabby, R; Fishman, A; Gadoth, N; Karmon, Y; Levavi, H; Levi, T; Loven, D; Sabach, G; Zart, R | 1 |
| Deng, Y; Xu, B; Xu, ZF | 1 |
| Breckenridge, CB; Burr, S; Choi, JS; Clark, JM; Holden, L; Ray, D; Sargent, D; Sheets, L; Soderlund, DM; Sturgess, N; Symington, S; Weiner, M | 1 |
| Friberg, O; Håkanson, E; Holm, J; Sunnermalm, L; Svedjeholm, R; Vanky, F; Vidlund, M | 1 |
| Bakuridze, K; Baş, DB; Gepdiremen, A; Gongadze, N; Savli, E | 1 |
| Lobner, D | 1 |
| Bradley, WG; Escala, W; Papapetropoulos, S; Zhai, RG; Zhou, X | 1 |
| Moon, HI; Park, WH | 1 |
| Aihara, M; Araie, M; Chen, YN; Lee, KY; Nakayama, M | 1 |
| Kumar, A; Nagesh Babu, G; Singh, RL | 1 |
| Lau, A; Tymianski, M | 1 |
| Davies, G; Haack, AK; Koch, RJ; Meshul, CK; Moore, C; Walker, RH | 1 |
| Feng, CR; Huang, Z; Li, ZY; Mao, QQ; Pan, AJ; Zhong, XM | 1 |
| Cho, SB; Kim, SK; Moon, HI | 1 |
| Lu, JH; Peng, YP; Qiu, YH | 1 |
| Cho, SB; Kim, SK; Lee, CH; Lee, JH; Lee, YC; Moon, HI | 1 |
| Muller, Gdo A; Severino, PC; Tasca, CI; Vandresen-Filho, S | 1 |
| Bae, K; Hwang, BY; Jeong, HY; Kim, JY; Kim, S; Lee, HK; Seong, YH | 1 |
| Armendáriz-Borunda, J; Beas-Zarate, C; Camins, A; Chaparro-Huerta, V; Flores-Soto, ME; Gudiño-Cabrera, G; Pallas, M; Rivera-Cervantes, MC; Torres-Mendoza, BM; Vazquez-Valls, E | 1 |
| Cakir, M; Coban, MK; Coskun, S; Hacimuftuoglu, A; Saruhan, F; Sengul, G | 1 |
| Bibb, JA; Drerup, JM; Lovinger, DM; Mathur, BN; O'Callaghan, JP; Thomas, R; Torres-Altoro, MI | 1 |
| Bincoletto, C; Carvalho, JT; Hirata, H; Lopes, GS; Oseki, KT; Rocha, KK; Rodrigues, L; Smaili, SS; Ureshino, RP | 1 |
| Estrada-Sánchez, AM; Guemez-Gamboa, A; Massieu, L; Montiel, T; Morán, J; Páramo, B | 1 |
| Albrecht, J; Aschner, M; Sidoryk-Węgrzynowicz, M; Zielińska, M | 1 |
| Brunt, TM; McMaster, MT; Niesink, RJ; van Amsterdam, JG | 1 |
| Kim, CY; Ma, CJ; Weon, JB; Yang, HJ | 1 |
| Ahlbrand, R; Gudelsky, GA; Horn, PS; Richtand, NM; Roenker, NL | 1 |
| Brimson, CA; Brimson, JM; Brimson, SJ; Rakkhitawatthana, V; Tencomnao, T | 1 |
| Morales, I; Rodriguez, M | 1 |
| Baker, DA; Bridges, R; Lobner, D; Lutgen, V | 1 |
| Bhuiyan, MI; Cho, KO; Ha, TJ; Kim, JY; Kim, SY | 1 |
| Fox, HS; Liu, J; Xiong, H; Zhang, J | 1 |
| Jin, ML; Kim, YH; Lee, SJ; Park, G; Park, SY | 1 |
| Cho, SO; Seong, YH | 1 |
| Behne, D; Bräuer, AU; Eyüpoglu, IY; Kühbacher, M; Kyriakopoulos, A; Ninnemann, O; Nitsch, R; Savaskan, NE | 1 |
| Blom, P; Kox, WJ; Müller, J; Petzelt, C; Schmehl, W | 1 |
| Akaike, A; Kaneko, S; Katsuki, H; Kume, T; Sugimoto, H; Takada, Y; Yonezawa, A | 1 |
| Angehagen, M; Ben-Menachem, E; Hansson, E; Rönnbäck, L | 1 |
| Amat, G; Armijo, JA; Cuadrado, A | 1 |
| Bergold, PJ; Gampel, M; Hassen, GW; Xiang, Z; Yuan, M | 1 |
| Antonelli, T; De Mattei, M; Ferraro, L; Finetti, S; Fournier, J; Fuxe, K; Tanganelli, S; Tomasini, MC | 1 |
| Chen, D; Chen, L; Dong, J; Li, T; Shi, N | 1 |
| Han, DY; Wang, DJ; Wang, JL; Yang, WY; Zhai, SQ | 1 |
| Kang, SY; Kim, SH; Kim, SR; Kim, YC; Koo, KA; Lee, HS; Ma, CJ; Park, MJ; Sung, SH | 1 |
| De Berardinis, MA; Domenici, MR; Frank, C; Grieco, R; Martire, A; Massotti, M; Minghetti, L; Nazzicone, V; Pepponi, R; Pèzzola, A; Pintor, A; Popoli, P; Potenza, RL; Reggio, R; Tebano, MT | 1 |
| Abreu, F; Bizarro, L; Cereser, V; Farina, M; Frizzo, ME; Manfroi, CB; Oliveira, A; Rocha, JB; Schwalm, FD; Souza, DO | 1 |
| Olney, JW | 1 |
| Dryhurst, G; Foster, SB; Miller, KE; Tang, H | 1 |
| Akaike, A; Katsuki, H; Kume, T; Sugimoto, H; Sugimoto, M; Takada-Takatori, Y | 1 |
| Brunette, E; Hewitt, M; Kiedrowski, L; Lortie, K; Morley, P; Tauskela, JS | 1 |
| Akaike, A; Doko, T; Kajiwara, A; Kume, T; Niidome, T; Sugimoto, H; Taguchi, R; Terauchi, T; Yonaga, M | 1 |
| Dluzen, DE; Jin, Y; Li, N; Liu, B | 1 |
| Gascon, E; Kiss, JZ; Klauser, P; Vutskits, L | 1 |
| Chiulli, N; Codazzi, F; Di Cesare, A; Gravaghi, C; Grohovaz, F; Zacchetti, D | 1 |
| Fang, JZ; Ma, J; Ma, RD; Yu, LJ; Yu, TX; Zhang, XY; Zhang, YP | 1 |
| Fricke, ST; Hailu, A; Moussa, CE; Rusnak, M; Sidhu, A | 1 |
| Ju, KL; Manley, NC; Sapolsky, RM | 1 |
| Büyükokuroglu, ME; Gepdiremen, A; Ors, R; Taştekin, A | 1 |
| Glowinski, J; Israël, M; Marin, P; Maus, M; Prémont, J | 1 |
| Akaike, A; Hara, H; Honda, Y; Kashii, S; Shimazawa, M; Toriu, N; Yasuyoshi, H; Zhang, S | 1 |
| Duchen, MR; Keelan, J; Khodorov, BI; Sobolevsky, AI; Vergun, O; Yelshansky, MV | 1 |
17 review(s) available for glutamic acid and Encephalopathy, Toxic
| Article | Year |
|---|---|
Research Progress on Neuroprotection of Insulin-like Growth Factor-1 towards Glutamate-Induced Neurotoxicity.
Topics: Glutamic Acid; Humans; Insulin-Like Growth Factor I; Nervous System Diseases; Neuroprotection; Neuroprotective Agents; Neurotoxicity Syndromes | 2022 |
Potential neurotoxic activity of diverse molecules released by astrocytes.
Topics: Amyloid beta-Peptides; Antigens, Surface; Astrocytes; Brain-Derived Neurotrophic Factor; Cathepsins; Ceramides; Chemokines; Chondroitin Sulfate Proteoglycans; Glutamic Acid; HMGB Proteins; Humans; Inflammation Mediators; Ligands; Lipocalins; Macrophage Inflammatory Proteins; Microglia; Neurotoxicity Syndromes; Neurotoxins; Nitric Oxide; Phospholipases A2, Secretory; Reactive Oxygen Species; Tumor Necrosis Factor-alpha | 2022 |
Glutamate Neurotoxicity and Destruction of the Blood-Brain Barrier: Key Pathways for the Development of Neuropsychiatric Consequences of TBI and Their Potential Treatment Strategies.
Topics: Blood-Brain Barrier; Brain; Brain Injuries; Brain Injuries, Traumatic; Glutamic Acid; Humans; Neurotoxicity Syndromes | 2022 |
Targeting Glutamate Neurotoxicity through Dietary Manipulation: Potential Treatment for Migraine.
Topics: Central Nervous System; Diet; Glutamic Acid; Humans; Migraine Disorders; Neurotoxicity Syndromes | 2023 |
Neurotoxicity in Gulf War Illness and the potential role of glutamate.
Topics: Animals; Brain; Glutamic Acid; Humans; Neurotoxicity Syndromes; Oxidative Stress; Persian Gulf Syndrome; Risk Factors; Up-Regulation; Veterans Health | 2020 |
Role of astrocytes in manganese mediated neurotoxicity.
Topics: Animals; Astrocytes; Glutamic Acid; Glutamine; Humans; Manganese; Neurotoxicity Syndromes | 2013 |
Mechanisms underlying taurine protection against glutamate-induced neurotoxicity.
Topics: Animals; Endoplasmic Reticulum; Glutamic Acid; Humans; Mitochondria; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; Taurine | 2013 |
Intracerebral hemorrhage injury mechanisms: glutamate neurotoxicity, thrombin, and Src.
Topics: Animals; Cerebral Hemorrhage; Glutamic Acid; Humans; Neurotoxicity Syndromes; Receptors, N-Methyl-D-Aspartate; src-Family Kinases; Thrombin | 2008 |
Mechanisms of beta-N-methylamino-L-alanine induced neurotoxicity.
Topics: Amino Acids, Diamino; Animals; Cell Death; Cyanobacteria Toxins; Cystine; Excitatory Amino Acid Agonists; Glutamic Acid; Humans; Neurotoxicity Syndromes; Neurotoxins; Oxidative Stress; Receptors, Glutamate | 2009 |
Glutamate receptors, neurotoxicity and neurodegeneration.
Topics: Animals; Antioxidants; Calcium; Calpain; Caspases; Cell Death; Free Radical Scavengers; Free Radicals; Glutamic Acid; Humans; Hypothalamus; Nerve Degeneration; Neurodegenerative Diseases; Neurotoxicity Syndromes; Nitric Oxide; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Sodium-Calcium Exchanger; Zinc | 2010 |
Cell signaling in NMDA preconditioning and neuroprotection in convulsions induced by quinolinic acid.
Topics: Animals; Brain; Brain Chemistry; Cerebrovascular Circulation; Excitatory Amino Acid Agonists; Glutamic Acid; Humans; Ischemic Preconditioning; N-Methylaspartate; Neuroprotective Agents; Neurotoxicity Syndromes; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Purinergic P1; Seizures; Signal Transduction | 2011 |
The role of mitochondrial function in glutamate-dependent metabolism in neuronal cells.
Topics: Alzheimer Disease; Animals; Autophagy; Calcium Signaling; Energy Metabolism; Excitatory Amino Acid Agents; Glutamic Acid; Humans; Huntington Disease; Mitochondria; Neuroglia; Neuronal Plasticity; Neurons; Neurotoxicity Syndromes; Parkinson Disease; Synaptic Transmission | 2011 |
Roles of glutamine in neurotransmission.
Topics: Animals; Central Nervous System; Epilepsy; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Models, Biological; Neuroglia; Neurons; Neurotoxicity Syndromes; Neurotransmitter Agents; Synaptic Transmission | 2010 |
Possible long-term effects of γ-hydroxybutyric acid (GHB) due to neurotoxicity and overdose.
Topics: Alcoholism; Anesthetics; Anesthetics, Dissociative; Animals; Central Nervous System Depressants; Cognition Disorders; Coma; Drug Overdose; Ethanol; Glutamic Acid; Humans; Illicit Drugs; Ketamine; Neurotoxicity Syndromes; Oxidative Stress; Sodium Oxybate; Substance Withdrawal Syndrome; Substance-Related Disorders; Succinate-Semialdehyde Dehydrogenase | 2012 |
Thinking outside the cleft to understand synaptic activity: contribution of the cystine-glutamate antiporter (System xc-) to normal and pathological glutamatergic signaling.
Topics: Amino Acid Transport System y+; Animals; Biological Transport; Central Nervous System; Cystine; Glutamic Acid; Glutathione; Humans; Mental Disorders; Neurodegenerative Diseases; Neurotoxicity Syndromes; Signal Transduction; Synapses | 2012 |
Excitatory neurotoxins as food additives: an evaluation of risk.
Topics: Adult; Age Factors; Aspartame; Aspartic Acid; Blood-Brain Barrier; Child; Cysteine; Dietary Supplements; Electrophysiology; Excitatory Amino Acids; Female; Food Analysis; Glutamic Acid; Humans; Neurotoxicity Syndromes; Neurotoxins; Pregnancy; Protein Hydrolysates; Risk Assessment; Risk Factors; Species Specificity | 1981 |
Potentially toxic effects of anaesthetics on the developing central nervous system.
Topics: Anesthetics; Animals; Animals, Newborn; Brain; Central Nervous System; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Neurotoxicity Syndromes | 2007 |
3 trial(s) available for glutamic acid and Encephalopathy, Toxic
| Article | Year |
|---|---|
Glutamic acid not beneficial for the prevention of vincristine neurotoxicity in children with cancer.
Topics: Adolescent; Antineoplastic Agents, Phytogenic; Child; Child, Preschool; Double-Blind Method; Female; Glutamic Acid; Humans; Male; Neoplasms; Neurotoxicity Syndromes; Vincristine | 2015 |
Long-term glutamate supplementation failed to protect against peripheral neurotoxicity of paclitaxel.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Phytogenic; Double-Blind Method; Female; Glutamic Acid; Humans; Middle Aged; Neurotoxicity Syndromes; Ovarian Neoplasms; Paclitaxel; Peripheral Nervous System Diseases; Treatment Outcome | 2009 |
The S-100B substudy of the GLUTAMICS trial: glutamate infusion not associated with sustained elevation of plasma S-100B after coronary surgery.
Topics: Aged; Aorta; Aortic Diseases; Biomarkers; Calcinosis; Cardiotonic Agents; Confusion; Coronary Artery Bypass; Coronary Artery Disease; Female; Glutamic Acid; Humans; Infusions, Intravenous; Male; Middle Aged; Nerve Growth Factors; Neurotoxicity Syndromes; Postoperative Complications; Postoperative Period; S100 Calcium Binding Protein beta Subunit; S100 Proteins; Ultrasonography | 2010 |
105 other study(ies) available for glutamic acid and Encephalopathy, Toxic
| Article | Year |
|---|---|
Calcitriol Pretreatment Attenuates Glutamate Neurotoxicity by Regulating NMDAR and CYP46A1 Gene Expression in Rats Subjected to Transient Middle Cerebral Artery Occlusion.
Topics: Animals; Brain Ischemia; Calcitriol; Cholesterol 24-Hydroxylase; Disease Models, Animal; Gene Expression; Glutamic Acid; Infarction, Middle Cerebral Artery; Ischemia; Male; Neuroprotective Agents; Neurotoxicity Syndromes; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Reperfusion Injury; Stroke | 2022 |
Topics: Antioxidants; Apoptosis; Caspase 3; Flavonoids; Fruit; Glutamic Acid; Hippocampus; Neuroprotective Agents; Neurotoxicity Syndromes; NF-E2-Related Factor 2; Oxidative Stress; Plant Extracts; Reactive Oxygen Species; Resveratrol; RNA, Messenger; Sirtuin 1; Syzygium | 2022 |
Novel neurosteroid pregnanolone pyroglutamate suppresses neurotoxicity syndrome induced by tetramethylenedisulfotetramine but is ineffective in a rodent model of infantile spasms.
Topics: Animals; Diazepam; Glutamic Acid; N-Methylaspartate; Neurosteroids; Neurotoxicity Syndromes; Pregnanolone; Pyrrolidonecarboxylic Acid; Rodentia; Spasm; Spasms, Infantile | 2023 |
Carboxyl-modified polystyrene microplastics induces neurotoxicity by affecting dopamine, glutamate, serotonin, and GABA neurotransmission in Caenorhabditis elegans.
Topics: Animals; Caenorhabditis elegans; Dopamine; gamma-Aminobutyric Acid; Glutamic Acid; Microplastics; Neurotoxicity Syndromes; Neurotransmitter Agents; Plastics; Polystyrenes; Serotonin; Synaptic Transmission | 2023 |
Protective Effect of 2',3'-Dihydroxy-4',6'-dimethoxychalcone on Glutamate-Induced Neurotoxicity in Primary Cortical Cultures.
Topics: Animals; Astrocytes; Cells, Cultured; Cerebral Cortex; Chalcones; Fetus; Glutamic Acid; Glutathione; Heme Oxygenase-1; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; Rats, Wistar | 2020 |
Coniferyl ferulate exerts antidepressant effect via inhibiting the activation of NMDAR-CaMKII-MAPKs and mitochondrial apoptotic pathways.
Topics: Animals; Antidepressive Agents; Apoptosis; Behavior, Animal; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Coumaric Acids; Depression; Glutamic Acid; Mice; Mitochondria; Mitogen-Activated Protein Kinases; Neuroprotective Agents; Neurotoxicity Syndromes; PC12 Cells; Rats; Receptors, N-Methyl-D-Aspartate | 2020 |
Oxidative stress accelerates synaptic glutamate dyshomeostasis and NMDARs disorder during methylmercury-induced neuronal apoptosis in rat cerebral cortex.
Topics: Animals; Antioxidants; Apoptosis; Cerebral Cortex; Glutamic Acid; Male; Methylmercury Compounds; Neurons; Neurotoxicity Syndromes; Oxidation-Reduction; Oxidative Stress; Rats; Rats, Wistar; Reactive Oxygen Species; Receptors, N-Methyl-D-Aspartate; Thioctic Acid | 2020 |
High ambient temperature increases the toxicity and lethality of 3,4-methylenedioxymethamphetamine and methcathinone.
Topics: Ammonia; Animals; Brain; Central Nervous System Stimulants; Disease Models, Animal; Female; Glutamic Acid; Hot Temperature; Male; Methamphetamine; Mice; Mice, Inbred C57BL; N-Methyl-3,4-methylenedioxyamphetamine; Neurotoxicity Syndromes; Propiophenones; Signal Transduction; Substance-Related Disorders | 2020 |
Triphenyl phosphate permeates the blood brain barrier and induces neurotoxicity in mouse brain.
Topics: Animals; Antioxidants; Apoptosis; Blood-Brain Barrier; Brain; Environmental Pollutants; Glutamic Acid; Hippocampus; Inflammation; Male; Mice; Nervous System; Neurotoxicity Syndromes; NF-E2-Related Factor 2; Organophosphates; Oxidative Stress; Phosphates; Superoxide Dismutase; Toxicity Tests | 2020 |
Adding value to polyvinylpolypyrrolidone winery residue: A resource of polyphenols with neuroprotective effects and ability to modulate type 2 diabetes-relevant enzymes.
Topics: Acetylcholinesterase; Aldehyde Reductase; Animals; Antioxidants; Cell Line; Diabetes Mellitus, Type 2; Glutamic Acid; Glycoside Hydrolase Inhibitors; GPI-Linked Proteins; Humans; Neuroprotective Agents; Neurotoxicity Syndromes; Oxidation-Reduction; Plant Extracts; Polyphenols; Povidone; Proanthocyanidins; Rats; Wine | 2020 |
Astrocytes respond to a neurotoxic Aβ fragment with state-dependent Ca
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Newborn; Astrocytes; Calcium; Calcium Signaling; Cells, Cultured; Disease Models, Animal; Glutamic Acid; Mice; Neurotoxicity Syndromes; Peptide Fragments; Plasma Membrane Calcium-Transporting ATPases; Receptors, Purinergic P2Y | 2021 |
Cleistocalyx nervosum var. paniala berry fruit protects neurotoxicity against endoplasmic reticulum stress-induced apoptosis.
Topics: Animals; Anthocyanins; Antioxidants; Apoptosis; Cell Line; Endoplasmic Reticulum Stress; Enzymes; Fruit; Gene Expression Regulation; Glutamic Acid; Hippocampus; Mice; Neurons; Neurotoxicity Syndromes; Plant Extracts; Reactive Oxygen Species; Syzygium | 2017 |
Disruption of glutamate neurotransmitter transmission is modulated by SNAP-25 in benzo[a]pyrene-induced neurotoxic effects.
Topics: Animals; Apoptosis; Benzo(a)pyrene; Cell Cycle; Cell Line, Tumor; Glutamic Acid; Hippocampus; Humans; Learning; Male; Microscopy, Electron, Transmission; Neurons; Neurotoxicity Syndromes; Rats, Sprague-Dawley; Synaptosomal-Associated Protein 25 | 2017 |
The Evaluation of BMAA Inhalation as a Potential Exposure Route Using a rat Model.
Topics: Amino Acids, Diamino; Animals; Cyanobacteria Toxins; Disease Models, Animal; Dose-Response Relationship, Drug; Glutamic Acid; Glutamine; Inhalation Exposure; Male; Necrosis; Neurotoxicity Syndromes; Neurotoxins; Rats; Rats, Sprague-Dawley; Time Factors; Tissue Distribution; Tritium | 2018 |
Developmental exposure to glyphosate-based herbicide and depressive-like behavior in adult offspring: Implication of glutamate excitotoxicity and oxidative stress.
Topics: Acetylcholinesterase; Age Factors; Animals; Astrocytes; Behavior, Animal; Binding Sites; Cholinergic Fibers; Depression; Female; Gestational Age; Glutamic Acid; Glycine; Glyphosate; GPI-Linked Proteins; Herbicides; Hippocampus; Male; Mitogen-Activated Protein Kinases; Molecular Docking Simulation; Molecular Structure; Motor Activity; Neurotoxicity Syndromes; NF-kappa B; Oxidative Stress; Pregnancy; Prenatal Exposure Delayed Effects; Protein Binding; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; S100 Calcium Binding Protein beta Subunit; Structure-Activity Relationship; Synaptic Transmission | 2017 |
Carbofuran causes neuronal vulnerability to glutamate by decreasing GluA2 protein levels in rat primary cortical neurons.
Topics: Acetylcholinesterase; Animals; Calcium; Carbofuran; Cell Membrane; Cells, Cultured; Cerebral Cortex; Cholinesterase Inhibitors; Female; Glutamic Acid; GPI-Linked Proteins; Neurons; Neurotoxicity Syndromes; Pregnancy; Rats, Wistar; Receptors, AMPA; Spermine | 2018 |
Prevention of oxytosis-induced c-Raf down-regulation by (arylthio)cyclopentenone prostaglandins is neuroprotective.
Topics: Animals; Antioxidants; Cell Line; Cell Survival; Cyclopentanes; Cytoprotection; Dose-Response Relationship, Drug; Down-Regulation; Extracellular Signal-Regulated MAP Kinases; Glutamic Acid; Glutathione; Hippocampus; MAP Kinase Kinase Kinases; Mice; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; Oxidative Stress; Phosphorylation; Prostaglandins; Protein Binding; Proto-Oncogene Proteins c-raf; Signal Transduction | 2017 |
Magnesium Sulfate Prevents Neurochemical and Long-Term Behavioral Consequences of Neonatal Excitotoxic Lesions: Comparison Between Male and Female Mice.
Topics: Aging; Animals; Animals, Newborn; Brain; Calcium Channel Blockers; Disease Models, Animal; Excitatory Amino Acid Agonists; Female; Functional Laterality; Gait Disorders, Neurologic; gamma-Aminobutyric Acid; Glutamic Acid; Ibotenic Acid; Longitudinal Studies; Magnesium Sulfate; Male; Mice; Motor Skills; Neurotoxicity Syndromes; Sex Factors; Vesicular Glutamate Transport Protein 1 | 2017 |
Cytoprotective Effects of Citicoline and Homotaurine against Glutamate and High Glucose Neurotoxicity in Primary Cultured Retinal Cells.
Topics: Cells, Cultured; Cytidine Diphosphate Choline; Glucose; Glutamic Acid; Neurotoxicity Syndromes; Retina; Taurine | 2017 |
Activation of PPARδ attenuates neurotoxicity by inhibiting lipopolysaccharide-triggered glutamate release in BV-2 microglial cells.
Topics: Animals; Cells, Cultured; Glutamic Acid; Janus Kinase 2; Lipopolysaccharides; Mice; Microglia; Neuroblastoma; Neurotoxicity Syndromes; PPAR delta; Reactive Oxygen Species; Signal Transduction; STAT1 Transcription Factor; Thiazoles | 2018 |
The Effects of Exposure to Mephedrone During Adolescence on Brain Neurotransmission and Neurotoxicity in Adult Rats.
Topics: Age Factors; Analysis of Variance; Animals; Brain; Central Nervous System Stimulants; Comet Assay; Disease Models, Animal; Dopamine; Glutamic Acid; Male; Methamphetamine; Microdialysis; Neurotoxicity Syndromes; Rats; Rats, Wistar; Serotonin; Synaptic Transmission | 2018 |
Chlorpyrifos oxon promotes tubulin aggregation via isopeptide cross-linking between diethoxyphospho-Lys and Glu or Asp: Implications for neurotoxicity.
Topics: Acetylcholinesterase; Amino Acid Sequence; Animals; Aspartic Acid; Chlorpyrifos; Cholinesterase Inhibitors; Cross-Linking Reagents; Crystallography, X-Ray; Glutamic Acid; Lysine; Models, Molecular; Neurotoxicity Syndromes; Peptides; Phosphorylation; Protein Aggregates; Swine; Tubulin; Tyrosine | 2018 |
Echinacoside, an Active Constituent of Cistanche Herba, Exerts a Neuroprotective Effect in a Kainic Acid Rat Model by Inhibiting Inflammatory Processes and Activating the Akt/GSK3β Pathway.
Topics: Animals; Brain; Cistanche; Cytokines; Disease Models, Animal; Epilepsy; Glutamic Acid; Glycogen Synthase Kinase 3 beta; Glycosides; Inflammation; Kainic Acid; Male; Microglia; Neuroprotective Agents; Neurotoxicity Syndromes; Phosphorylation; Phytotherapy; Plant Extracts; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Rats, Sprague-Dawley; Seizures; Signal Transduction | 2018 |
Brain metabolic alterations in patients with long-term calcineurin inhibitor therapy after liver transplantation.
Topics: Adenosine Triphosphate; Adult; Aged; Brain; Calcineurin Inhibitors; Female; Glutamic Acid; Glutamine; Humans; Liver Transplantation; Male; Middle Aged; Neurotoxicity Syndromes | 2019 |
Cellular metabolomics reveals glutamate and pyrimidine metabolism pathway alterations induced by BDE-47 in human neuroblastoma SK-N-SH cells.
Topics: Biomarkers; Cell Line, Tumor; Cell Survival; Glutamic Acid; Halogenated Diphenyl Ethers; Humans; Metabolomics; Mitochondria; Neuroblastoma; Neurotoxicity Syndromes; Oxidative Stress; Pyrimidines; Signal Transduction; Toxicity Tests | 2019 |
Protein kinase C is involved in the neuroprotective effect of berberine against intrastriatal injection of quinolinic acid-induced biochemical alteration in mice.
Topics: Animals; Berberine; Cognitive Dysfunction; Disease Models, Animal; Glutamic Acid; Glycogen Synthase Kinase 3 beta; Male; Mice; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; Protein Kinase C; Quinolinic Acid; Signal Transduction | 2019 |
Erythropoietin protects polychlorinated biphenyl (Aroclor 1254) induced neurotoxicity in mice.
Topics: Animals; Antioxidants; Behavior, Animal; Brain; Chlorodiphenyl (54% Chlorine); Cholesterol; Cognition Disorders; Dose-Response Relationship, Drug; Erythropoietin; Glutamic Acid; Male; Maze Learning; Memory; Mice; Neuroprotective Agents; Neurotoxicity Syndromes; Oxidative Stress; Triglycerides | 2013 |
The role of the neuropeptide somatostatin on methamphetamine and glutamate-induced neurotoxicity in the striatum of mice.
Topics: Animals; Corpus Striatum; Disease Models, Animal; Fluoresceins; Glutamic Acid; Male; Methamphetamine; Mice; Mice, Inbred ICR; Microinjections; Neurotoxicity Syndromes; Neurotoxins; Nitric Oxide; Octreotide; Somatostatin; Tyrosine; Tyrosine 3-Monooxygenase | 2013 |
Kallikrein 6 signals through PAR1 and PAR2 to promote neuron injury and exacerbate glutamate neurotoxicity.
Topics: Animals; Cells, Cultured; Cerebellum; Female; Glutamic Acid; Kallikreins; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Neurons; Neurons; Neurotoxicity Syndromes; Receptor, PAR-1; Receptor, PAR-2; RNA; Signal Transduction; Spinal Cord; Spinal Cord Injuries; Thrombin | 2013 |
Effects of Cymbopogon citratus and Ferula assa-foetida extracts on glutamate-induced neurotoxicity.
Topics: Animals; Cell Cycle Checkpoints; Cell Survival; Cerebellum; Cymbopogon; Ferula; Glutamic Acid; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; Plant Extracts; Plant Oils; Rats | 2013 |
Identification of Bax-interacting proteins in oligodendrocyte progenitors during glutamate excitotoxicity and perinatal hypoxia-ischemia.
Topics: Animals; Animals, Newborn; Apoptosis; bcl-2-Associated X Protein; Cells, Cultured; Cerebellum; Culture Media, Conditioned; Disease Models, Animal; Gene Expression Regulation; Glutamic Acid; Humans; Hypoxia-Ischemia, Brain; Insulin-Like Growth Factor I; Mitochondria; Neurotoxicity Syndromes; Oligodendroglia; Protein Transport; Rats; Rats, Wistar; Stem Cells; Time Factors | 2013 |
Glutamate neurotoxicity is involved in the neurological damage in patients undergoing extracorporeal circulation.
Topics: Extracorporeal Circulation; Female; Glutamic Acid; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neurotoxicity Syndromes; Prospective Studies; Tomography, X-Ray Computed | 2014 |
Potential mechanisms of neurobehavioral disturbances in mice caused by sub-chronic exposure to low-dose VOCs.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Behavior, Animal; Benzene; Brain; Choline O-Acetyltransferase; Formaldehyde; Glutamic Acid; Hand Strength; Male; Malondialdehyde; Maze Learning; Memory; Mice; Neurotoxicity Syndromes; Reactive Oxygen Species; Receptors, N-Methyl-D-Aspartate; Toluene; Volatile Organic Compounds; Xylenes | 2014 |
Mechanisms underlying the neurotoxicity induced by glyphosate-based herbicide in immature rat hippocampus: involvement of glutamate excitotoxicity.
Topics: Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Extracellular Signal-Regulated MAP Kinases; Female; Glutamic Acid; Glycine; Glyphosate; Herbicides; Hippocampus; Lactation; Male; Maternal Exposure; Neurotoxicity Syndromes; Oxidative Stress; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2014 |
β-cypermethrin-induced acute neurotoxicity in the cerebral cortex of mice.
Topics: Acute Disease; Animals; Cerebral Cortex; Dose-Response Relationship, Drug; Female; Glutamate-Ammonia Ligase; Glutamic Acid; Insecticides; Male; Mice; Neurotoxicity Syndromes; Pyrethrins | 2015 |
Aloysia gratissima prevents cellular damage induced by glutamatergic excitotoxicity.
Topics: Animals; Biological Transport; Cell Death; Cell Survival; Coumaric Acids; Excitatory Amino Acid Agonists; Excitatory Amino Acids; Glutamic Acid; Hippocampus; Male; Mice, Inbred Strains; Neuroprotective Agents; Neurotoxicity Syndromes; Phosphatidylinositol 3-Kinase; Phytotherapy; Plant Extracts; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate; Seizures; Verbenaceae | 2014 |
Ammonium: the deadly toxin you don't want to miss when using mood stabilizers.
Topics: Adult; Aged, 80 and over; Ammonium Compounds; Female; Glutamic Acid; Humans; Hyperammonemia; Male; Mood Disorders; Neurotoxicity Syndromes; Valproic Acid; Young Adult | 2013 |
Glycine transporters type 1 inhibitor promotes brain preconditioning against NMDA-induced excitotoxicity.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Excitatory Amino Acid Agonists; Fluoresceins; Gas Chromatography-Mass Spectrometry; Gene Expression Regulation; Glutamic Acid; Glycine; Glycine Plasma Membrane Transport Proteins; Hippocampus; Male; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neurotoxicity Syndromes; Sarcosine; Time Factors; Tritium | 2015 |
Alpha-lipoic acid protects against methylmercury-induced neurotoxic effects via inhibition of oxidative stress in rat cerebral cortex.
Topics: Animals; Cerebral Cortex; Environmental Pollutants; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Female; Glutamic Acid; Male; Malondialdehyde; Methylmercury Compounds; Neuroprotective Agents; Neurotoxicity Syndromes; Oxidative Stress; Rats, Wistar; Reactive Oxygen Species; Thioctic Acid | 2015 |
Dysregulation of glutamine transporter SNAT1 in Rett syndrome microglia: a mechanism for mitochondrial dysfunction and neurotoxicity.
Topics: Adenosine Triphosphate; Amino Acid Transport System A; Animals; Glutamic Acid; Glycine; Methyl-CpG-Binding Protein 2; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Mitochondrial Diseases; Neurotoxicity Syndromes; Oxygen Consumption; Primary Cell Culture; Rett Syndrome | 2015 |
Staphylococcal α-hemolysin is neurotoxic and causes lysis of brain cells in vivo and in vitro.
Topics: Animals; Astrocytes; Bacterial Toxins; Brain; Brain Edema; Cell Death; Cells, Cultured; gamma-Aminobutyric Acid; Glutamic Acid; Hemolysin Proteins; Leukocytosis; Male; Neurotoxicity Syndromes; Neutrophil Infiltration; Presynaptic Terminals; Rats, Wistar; Time Factors; Zinc | 2015 |
Macrophages treated with particulate matter PM2.5 induce selective neurotoxicity through glutaminase-mediated glutamate generation.
Topics: Air Pollutants; Animals; Blotting, Western; Capillary Permeability; Cells, Cultured; Chromatography, High Pressure Liquid; Endothelium, Vascular; Fluorescent Antibody Technique; Glutamic Acid; Glutaminase; Humans; Macrophages; Neurons; Neurotoxicity Syndromes; Particulate Matter; Rats; Rats, Sprague-Dawley | 2015 |
Protective role of Kv7 channels in oxygen and glucose deprivation-induced damage in rat caudate brain slices.
Topics: Animals; Brain; Caudate Nucleus; Dopamine; Dopamine Antagonists; Glucose; Glutamic Acid; Hypoxia, Brain; KCNQ Potassium Channels; L-Lactate Dehydrogenase; Male; Neurotoxicity Syndromes; Organ Culture Techniques; Rats; Rats, Wistar | 2015 |
Hesperidin inhibits glutamate release and exerts neuroprotection against excitotoxicity induced by kainic acid in the hippocampus of rats.
Topics: 4-Aminopyridine; Animals; Calcium; Disease Models, Animal; Egtazic Acid; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Hesperidin; Hippocampus; Kainic Acid; Male; Membrane Potentials; Neuroprotective Agents; Neurotoxicity Syndromes; Potassium Channel Blockers; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Synaptosomes; Tetrodotoxin | 2015 |
MPA-capped CdTe quantum dots exposure causes neurotoxic effects in nematode Caenorhabditis elegans by affecting the transporters and receptors of glutamate, serotonin and dopamine at the genetic level, or by increasing ROS, or both.
Topics: Animals; Cadmium; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Carrier Proteins; Dopamine; Glutamic Acid; Neurotoxicity Syndromes; Quantum Dots; Reactive Oxygen Species; Serotonin; Tellurium | 2015 |
Neuropeptide Cycloprolylglycine Exhibits Neuroprotective Activity after Systemic Administration to Rats with Modeled Incomplete Global Ischemia and in In Vitro Modeled Glutamate Neurotoxicity.
Topics: Animals; Brain Ischemia; Cell Line; Glutamic Acid; Male; Neuroprotective Agents; Neurotoxicity Syndromes; Peptides, Cyclic; Rats | 2016 |
Protective effect of citicoline against aluminum-induced cognitive impairments in rats.
Topics: Aluminum; Aluminum Chloride; Aluminum Compounds; Animals; Avoidance Learning; Behavior, Animal; Chlorides; Cognitive Dysfunction; Cytidine Diphosphate Choline; Environmental Pollutants; Glutamic Acid; Hippocampus; Injections, Intraperitoneal; Lipid Peroxidation; Male; Maze Learning; Memory, Short-Term; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; Nitric Oxide; Nootropic Agents; Oxidative Stress; Rats, Wistar | 2017 |
Neuroprotective effects of intrastriatal injection of rapamycin in a mouse model of excitotoxicity induced by quinolinic acid.
Topics: Animals; Body Weight; Corpus Striatum; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Glutamic Acid; Male; Mice; Mice, Inbred C57BL; Movement Disorders; Nerve Degeneration; Neuroglia; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; Postural Balance; Potassium Chloride; Quinolinic Acid; Sirolimus; Synaptosomes | 2017 |
Quinic acid derivatives from Saussurea triangulata attenuates glutamate-induced neurotoxicity in primary cultured rat cortical cells.
Topics: Animals; Cell Survival; Cells, Cultured; Cerebral Cortex; Glutamic Acid; Neuroprotective Agents; Neurotoxicity Syndromes; Quinic Acid; Rats; Saussurea | 2009 |
Cudratricusxanthone A protects mouse hippocampal cells against glutamate-induced neurotoxicity via the induction of heme oxygenase-1.
Topics: Animals; Cell Line; Glutamic Acid; Heme Oxygenase-1; Hippocampus; Mice; Moraceae; Neurotoxicity Syndromes; Plant Bark; Plant Roots; Xanthones | 2008 |
TNF-alpha-mediates neuroprotection against glutamate-induced excitotoxicity via NF-kappaB-dependent up-regulation of K2.2 channels.
Topics: Animals; Cell Survival; Cells, Cultured; Cerebral Cortex; Embryo, Mammalian; Enzyme Inhibitors; Glutamic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; NF-kappa B; Nitriles; Receptors, Tumor Necrosis Factor, Type I; Receptors, Tumor Necrosis Factor, Type II; RNA, Small Interfering; Small-Conductance Calcium-Activated Potassium Channels; Subcellular Fractions; Sulfones; Time Factors; Tumor Necrosis Factor-alpha; Up-Regulation | 2008 |
The neuroprotective effects of benzylideneacetophenone derivatives on excitotoxicity and inflammation via phosphorylated Janus tyrosine kinase 2/phosphorylated signal transducer and activator of transcription 3 and mitogen-activated protein K pathways.
Topics: Animals; Brain Ischemia; Chalcone; Disease Models, Animal; DNA-Binding Proteins; Glutamic Acid; Hydrogen Peroxide; Inflammation; Janus Kinase 2; Lipopolysaccharides; MAP Kinase Signaling System; Mice; Microglia; Mitogen-Activated Protein Kinases; Neuroprotective Agents; Neurotoxicity Syndromes; Nitric Oxide; Phosphorylation; Propiophenones; Signal Transduction; Transcription Factors | 2009 |
Neurochemical and electrophysiological diagnosis of reversible neurotoxicity in earthworms exposed to sublethal concentrations of CL-20.
Topics: Animals; Aza Compounds; Biogenic Monoamines; Dose-Response Relationship, Drug; Electrophysiology; Environmental Exposure; Explosive Agents; gamma-Aminobutyric Acid; Glutamic Acid; Heterocyclic Compounds; Lethal Dose 50; Neurotoxicity Syndromes; Neurotoxins; Oligochaeta; Receptor, Muscarinic M3; Time Factors; Toxicity Tests | 2010 |
Erythropoietin protects primary cultures of rat cortical neurons from hypoxia-induced toxicity through attenuating both glutamate release and NMDA receptor evoked neurotoxicity pathway.
Topics: Animals; Cell Hypoxia; Cell Survival; Cells, Cultured; Cerebral Cortex; Erythropoietin; Glutamic Acid; Humans; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Signal Transduction | 2009 |
Achyranthes bidentata Blume extract protects cultured hippocampal neurons against glutamate-induced neurotoxicity.
Topics: Achyranthes; Animals; Apoptosis; Calcium; Cell Survival; Dose-Response Relationship, Drug; Down-Regulation; Genes, bcl-2; Glutamic Acid; Hippocampus; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; Phytotherapy; Plant Extracts; Plant Roots; Rats; RNA, Messenger | 2009 |
Protective effects of MK-801 on manganese-induced glutamate metabolism disorder in rat striatum.
Topics: Animals; Apoptosis; Behavior, Animal; Corpus Striatum; Dizocilpine Maleate; Environmental Pollutants; Female; Glutamate-Ammonia Ligase; Glutamic Acid; Glutaminase; Male; Manganese; Microscopy, Electron, Transmission; Neuroprotective Agents; Neurotoxicity Syndromes; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2010 |
Evidence for a separate mechanism of toxicity for the Type I and the Type II pyrethroid insecticides.
Topics: Animals; Brain; Calcium; Cell Line, Tumor; Disease Models, Animal; Factor Analysis, Statistical; Glutamic Acid; Insecticides; Ion Channel Gating; Ion Channels; Membrane Potentials; Mice; Neuroblastoma; Neurotoxicity Syndromes; Oocytes; Patch-Clamp Techniques; Principal Component Analysis; Pyrethrins; Rats; Synaptosomes; Xenopus | 2009 |
Protection in glutamate-induced neurotoxicity by imidazoline receptor agonist moxonidine.
Topics: Animals; Animals, Newborn; Cell Count; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Frontal Lobe; Gene Expression Regulation, Enzymologic; Glutamic Acid; Imidazoles; Imidazoline Receptors; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; p38 Mitogen-Activated Protein Kinases; Rats; Rats, Sprague-Dawley | 2009 |
BMAA neurotoxicity in Drosophila.
Topics: Alanine; Amino Acids, Diamino; Analysis of Variance; Animals; Behavior, Animal; Chromatography, High Pressure Liquid; Cyanobacteria Toxins; Disease Models, Animal; Dose-Response Relationship, Drug; Drosophila melanogaster; Female; Glutamic Acid; Leucine; Longevity; Lysine; Male; Neurotoxicity Syndromes; Neurotoxins | 2009 |
Four carotenoids from Pittosporum tobira protect primary cultured rat cortical cells from glutamate-induced toxicity.
Topics: Animals; Carotenoids; Cells, Cultured; Drug Evaluation, Preclinical; Glutamic Acid; Neuroprotective Agents; Neurotoxicity Syndromes; Phytotherapy; Plant Extracts; Rats; Rats, Sprague-Dawley; Rosales; Seeds | 2010 |
Brimonidine is neuroprotective against glutamate-induced neurotoxicity, oxidative stress, and hypoxia in purified rat retinal ganglion cells.
Topics: Animals; Brimonidine Tartrate; Cell Hypoxia; Cell Separation; Cell Survival; Glutamic Acid; Neuroprotective Agents; Neurotoxicity Syndromes; Oxidative Stress; Quinoxalines; Rats; Rats, Wistar; Retinal Ganglion Cells | 2010 |
Chronic pretreatment with acetyl-L-carnitine and ±DL-α-lipoic acid protects against acute glutamate-induced neurotoxicity in rat brain by altering mitochondrial function.
Topics: Acetylcarnitine; Animals; Brain; Drug Therapy, Combination; Glutamic Acid; Male; Mitochondria; Neuroprotective Agents; Neurotoxicity Syndromes; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Thioctic Acid; Treatment Outcome | 2011 |
Effects of zona incerta lesions on striatal neurochemistry and behavioral asymmetry in 6-hydroxydopamine-lesioned rats.
Topics: Adrenergic Agents; Animals; Behavioral Symptoms; Corpus Striatum; Disease Models, Animal; Dopamine; Glutamic Acid; Male; Microdialysis; Motor Activity; Neurochemistry; Neurotoxicity Syndromes; Oxidopamine; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Subthalamus; Tyrosine 3-Monooxygenase | 2010 |
Protective effects of paeoniflorin against glutamate-induced neurotoxicity in PC12 cells via antioxidant mechanisms and Ca(2+) antagonism.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents; Antioxidants; Benzoates; Bridged-Ring Compounds; Calbindin 1; Calbindins; Calcium; Cell Survival; Glucosides; Glutamic Acid; Humans; Malondialdehyde; Molecular Structure; Monoterpenes; Neuroprotective Agents; Neurotoxicity Syndromes; Oxidative Stress; PC12 Cells; Rats; Reactive Oxygen Species; S100 Calcium Binding Protein G; Superoxide Dismutase | 2010 |
Neuroprotective effects of a sesquiterpene lactone and flavanones from Paulownia tomentosa Steud. against glutamate-induced neurotoxicity in primary cultured rat cortical cells.
Topics: Animals; Cell Culture Techniques; Cells, Cultured; Cerebral Cortex; Flavanones; Glutamic Acid; Lactones; Magnoliopsida; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; Plant Extracts; Plants, Medicinal; Rats; Rats, Sprague-Dawley; Sesquiterpenes | 2010 |
[Interleukin-6 prevents cultured cerebellar granule neurons from glutamate-induced neurotoxicity].
Topics: Animals; Cells, Cultured; Cerebellum; Glutamic Acid; Interleukin-6; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; Rats; Rats, Sprague-Dawley | 2006 |
Protective effects of methoxyflavone derivatives from black galingale against glutamate induced neurotoxicity in primary cultured rat cortical cells.
Topics: Animals; Cells, Cultured; Cerebral Cortex; Flavones; Glutamic Acid; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; Plant Extracts; Plants, Medicinal; Rats; Rats, Sprague-Dawley; Rhizome; Zingiberaceae | 2011 |
Neuroprotection of the leaf and stem of Vitis amurensis and their active compounds against ischemic brain damage in rats and excitotoxicity in cultured neurons.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Brain Edema; Brain Injuries; Brain Ischemia; Cyclooxygenase 2; Female; Glutamic Acid; Glutathione; Lipid Peroxidation; Male; Methanol; Molecular Structure; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; Phytotherapy; Plant Extracts; Plant Leaves; Plant Stems; Pregnancy; Primary Cell Culture; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Reperfusion Injury; Vitis | 2012 |
HIF-1α expression in the hippocampus and peripheral macrophages after glutamate-induced excitotoxicity.
Topics: Age Factors; Animals; Animals, Newborn; Disease Models, Animal; Erythropoietin; Female; Gene Expression Regulation, Developmental; Glial Fibrillary Acidic Protein; Glutamic Acid; Hippocampus; Hypoxia-Inducible Factor 1, alpha Subunit; Macrophages; Male; Neurons; Neurotoxicity Syndromes; Neurotoxins; Pregnancy; Rats; Rats, Wistar; RNA, Messenger; Vascular Endothelial Growth Factor A | 2011 |
Neuroprotective effect of ACE inhibitors in glutamate - induced neurotoxicity: rat neuron culture study.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Animals, Newborn; Captopril; Cell Survival; Cells, Cultured; Glutamic Acid; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; Perindopril; Ramipril; Rats; Rats, Sprague-Dawley | 2011 |
Organophosphates dysregulate dopamine signaling, glutamatergic neurotransmission, and induce neuronal injury markers in striatum.
Topics: Animals; Animals, Newborn; Biomarkers; Blotting, Western; Chlorpyrifos; Cholinesterase Inhibitors; Corpus Striatum; Cyclin-Dependent Kinase 5; Dopamine; Female; Glutamic Acid; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Neurons; Neurotoxicity Syndromes; Organophosphates; Patch-Clamp Techniques; Phosphorylation; Pyridostigmine Bromide; Receptors, Dopamine D1; Signal Transduction; Synaptic Transmission; tau Proteins | 2011 |
Activation of NOX2 by the stimulation of ionotropic and metabotropic glutamate receptors contributes to glutamate neurotoxicity in vivo through the production of reactive oxygen species and calpain activation.
Topics: Animals; Calcium-Binding Proteins; Calpain; Corpus Striatum; Disease Models, Animal; Drug Interactions; Excitatory Amino Acid Agents; Fluoresceins; Gene Expression Regulation; Glutamic Acid; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Microfilament Proteins; Microglia; NADPH Oxidase 2; NADPH Oxidases; Neurons; Neurotoxicity Syndromes; Organic Chemicals; Phosphopyruvate Hydratase; Reactive Oxygen Species; Receptors, Immunologic; Receptors, Ionotropic Glutamate; Receptors, Metabotropic Glutamate; Time Factors | 2011 |
Neuroprotective compounds isolated from Cynanchum paniculatum.
Topics: Animals; Cell Culture Techniques; Cell Line; Cell Survival; Chromatography, High Pressure Liquid; Cynanchum; Dose-Response Relationship, Drug; Glutamic Acid; Mice; Molecular Structure; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; Plant Roots; Reactive Oxygen Species | 2012 |
Evidence for involvement of nitric oxide and GABA(B) receptors in MK-801- stimulated release of glutamate in rat prefrontal cortex.
Topics: Animals; Disease Models, Animal; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Extracellular Fluid; GABA-B Receptor Agonists; Glutamic Acid; Male; Nerve Tissue Proteins; Neurons; Neurotoxicity Syndromes; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2012 |
Rhinacanthus nasutus extracts prevent glutamate and amyloid-β neurotoxicity in HT-22 mouse hippocampal cells: possible active compounds include lupeol, stigmasterol and β-sitosterol.
Topics: Acanthaceae; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Cell Line; Glutamic Acid; Glutathione; Hippocampus; Mice; Neuroprotective Agents; Neurotoxicity Syndromes; Oxidative Stress; Pentacyclic Triterpenes; Plant Extracts; Plant Leaves; Plant Roots; Reactive Oxygen Species; Sitosterols; Stigmasterol | 2012 |
Self-induced accumulation of glutamate in striatal astrocytes and basal ganglia excitotoxicity.
Topics: Analysis of Variance; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Astrocytes; Basal Ganglia; Corpus Striatum; Disease Models, Animal; Glial Fibrillary Acidic Protein; Glutamate-Ammonia Ligase; Glutamic Acid; Male; Microdialysis; Neurotoxicity Syndromes; Rats; Rats, Sprague-Dawley; Time Factors | 2012 |
Anthocyanins extracted from black soybean seed coat protect primary cortical neurons against in vitro ischemia.
Topics: Animals; Anthocyanins; Brain Ischemia; Cell Death; Cells, Cultured; Cerebral Cortex; Glutamic Acid; Glycine max; L-Lactate Dehydrogenase; Membrane Potential, Mitochondrial; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; Plant Extracts; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Seeds | 2012 |
N-methyl-D-aspartate receptor-mediated axonal injury in adult rat corpus callosum.
Topics: Action Potentials; Amyloid beta-Protein Precursor; Animals; Axons; Corpus Callosum; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acids; Female; Glutamic Acid; In Vitro Techniques; Male; Myelin Basic Protein; Nerve Fibers, Myelinated; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; Oligodendroglia; Patch-Clamp Techniques; Phosphopyruvate Hydratase; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2013 |
Acanthopanax senticosus exerts neuroprotective effects through HO-1 signaling in hippocampal and microglial cells.
Topics: Animals; Cell Death; Cell Line; Cyclic AMP Response Element-Binding Protein; Drug Evaluation, Preclinical; Eleutherococcus; Glutamic Acid; Heme Oxygenase-1; Hippocampus; Inflammation Mediators; Lipopolysaccharides; Membrane Proteins; Mice; Microglia; Neuroprotective Agents; Neurotoxicity Syndromes; NF-E2-Related Factor 2; Nitric Oxide; Plant Extracts; Plants, Medicinal; Reactive Oxygen Species; Signal Transduction | 2013 |
Protective effect of fangchinoline on cyanide-induced neurotoxicity in cultured rat cerebellar granule cells.
Topics: Alkaloids; Animals; Antioxidants; Benzylisoquinolines; Calcium; Cell Death; Cells, Cultured; Cerebellum; Coloring Agents; Cyanides; Cytoplasmic Granules; Glutamic Acid; Neurons; Neurotoxicity Syndromes; Oxidants; Rats; Rats, Sprague-Dawley; Stephania; Tetrazolium Salts; Thiazoles; Trypan Blue | 2002 |
Selenium deficiency increases susceptibility to glutamate-induced excitotoxicity.
Topics: Animals; Cell Death; Cell Line; Disease Susceptibility; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Models, Neurological; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; NF-kappa B; Oxidative Stress; Protein Biosynthesis; Rats; Seizures; Selenium; Transcription Factor AP-1 | 2003 |
Prevention of neurotoxicity in hypoxic cortical neurons by the noble gas xenon.
Topics: Anesthetics, Inhalation; Animals; Benzylamines; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cell Hypoxia; Cell Survival; Cells, Cultured; Cerebral Cortex; Chelating Agents; Dizocilpine Maleate; Egtazic Acid; Glutamic Acid; Helium; Hypoxia, Brain; L-Lactate Dehydrogenase; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; Nitrogen; Rats; Sulfonamides; Xenon | 2003 |
Nicotinic acetylcholine receptor-mediated neuroprotection by donepezil against glutamate neurotoxicity in rat cortical neurons.
Topics: Animals; Apoptosis; Cells, Cultured; Cerebral Cortex; Donepezil; Drug Antagonism; Glutamic Acid; Indans; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; Nicotinic Antagonists; Piperidines; Rats; Rats, Wistar; Receptors, Nicotinic | 2003 |
Topiramate protects against glutamate- and kainate-induced neurotoxicity in primary neuronal-astroglial cultures.
Topics: Animals; Animals, Newborn; Anticonvulsants; Astrocytes; Calcium; Calcium Signaling; Cell Membrane; Cell Survival; Cells, Cultured; Fructose; Glutamic Acid; Immunohistochemistry; Kainic Acid; Nerve Degeneration; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; Phenytoin; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; Topiramate; Valproic Acid | 2003 |
Is the interaction between felbamate and valproate against seizures induced by 4-aminopyridine and pentylenetetrazole in mice beneficial?
Topics: 4-Aminopyridine; Analysis of Variance; Animals; Brain; Chromatography, Liquid; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Felbamate; gamma-Aminobutyric Acid; Glutamic Acid; Male; Mice; Mice, Inbred Strains; Neurotoxicity Syndromes; Pentylenetetrazole; Phenylcarbamates; Propylene Glycols; Reaction Time; Seizures; Toxicity Tests; Valproic Acid | 2003 |
Lactate induced excitotoxicity in hippocampal slice cultures.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Acidosis; Analysis of Variance; Animals; Animals, Newborn; Cell Death; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glucose; Glutamic Acid; Hippocampus; Hydrogen-Ion Concentration; In Vitro Techniques; Intracellular Space; Lactic Acid; Neurotoxicity Syndromes; Propidium; Rats; Rats, Sprague-Dawley; Time Factors; Tritium | 2004 |
Neurotensin enhances endogenous extracellular glutamate levels in primary cultures of rat cortical neurons: involvement of neurotensin receptor in NMDA induced excitotoxicity.
Topics: Animals; Bisbenzimidazole; Calcium; Cells, Cultured; Cerebral Cortex; Chromatin; Coloring Agents; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Extracellular Space; Glutamic Acid; N-Methylaspartate; Naphthalenes; Neurons; Neurotensin; Neurotoxicity Syndromes; Peptide Fragments; Pyrazoles; Quinolines; Rats; Receptors, Neurotensin | 2004 |
[Effects of estradiol on deltamethrin-induced neurotoxicity in rat cerebro-cortical synaptosomes].
Topics: Animals; Aspartic Acid; Cerebral Cortex; Estradiol; Glutamic Acid; Insecticides; Neurotoxicity Syndromes; Nitriles; Pyrethrins; Rats; Rats, Wistar; Synaptosomes | 2004 |
Basic fibroblast growth factor protects auditory neurons and hair cells from glutamate neurotoxicity and noise exposure.
Topics: Animals; Audiometry, Evoked Response; Cell Survival; Cells, Cultured; Cochlear Nerve; Fibroblast Growth Factor 2; Glutamic Acid; Guinea Pigs; Hair Cells, Auditory; Hearing Loss, Noise-Induced; Mice; Neurons; Neurotoxicity Syndromes; Noise; Spiral Ganglion | 2004 |
Aristolactam BII of Saururus chinensis attenuates glutamate-induced neurotoxicity in rat cortical cultures probably by inhibiting nitric oxide production.
Topics: Animals; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Glutamic Acid; Lactams; Neuroprotective Agents; Neurotoxicity Syndromes; Nitric Oxide; Phytotherapy; Plant Components, Aerial; Plant Extracts; Rats; Rats, Sprague-Dawley; Saururaceae | 2004 |
Neuroprotective effects of the mGlu5R antagonist MPEP towards quinolinic acid-induced striatal toxicity: involvement of pre- and post-synaptic mechanisms and lack of direct NMDA blocking activity.
Topics: Animals; Body Weight; Calcium; Cells, Cultured; Electroencephalography; Excitatory Amino Acid Antagonists; Glutamic Acid; L-Lactate Dehydrogenase; Male; Maze Learning; Microdialysis; N-Methylaspartate; Neostriatum; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; Neurotoxins; Pyridines; Quinolinic Acid; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate | 2004 |
Maternal milk as methylmercury source for suckling mice: neurotoxic effects involved with the cerebellar glutamatergic system.
Topics: Animals; Animals, Suckling; Antioxidants; Behavior, Animal; Body Weight; Catalase; Cerebellum; Female; Glutamic Acid; Glutathione Peroxidase; Hydrogen Peroxide; In Vitro Techniques; Male; Methylmercury Compounds; Mice; Milk; Nerve Tissue Proteins; Neurotoxicity Syndromes; Sulfhydryl Compounds | 2004 |
Increased extracellular glutamate evoked by 1-methyl-4-phenylpyridinium [MPP(+)] in the rat striatum is not essential for dopaminergic neurotoxicity and is not derived from released glutathione.
Topics: 1-Methyl-4-phenylpyridinium; Amino Acids; Animals; Chromatography, High Pressure Liquid; Dopamine; Dopamine Agents; Electrochemistry; Enzyme Inhibitors; Extracellular Space; gamma-Glutamyltransferase; Glutamic Acid; Glutathione; Immunohistochemistry; Isoxazoles; Male; Microdialysis; Neostriatum; Neurotoxicity Syndromes; Rats; Rats, Sprague-Dawley; Serotonin | 2005 |
Acetylcholinesterase inhibitors used in treatment of Alzheimer's disease prevent glutamate neurotoxicity via nicotinic acetylcholine receptors and phosphatidylinositol 3-kinase cascade.
Topics: Alzheimer Disease; Animals; Apoptosis; Blotting, Western; Cell Count; Cells, Cultured; Cerebral Cortex; Cholinergic Antagonists; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; Enzyme Inhibitors; Glutamic Acid; Neurons; Neurotoxicity Syndromes; Phosphatidylinositol 3-Kinases; Rats; Rats, Wistar; Receptors, Nicotinic; Time Factors | 2006 |
Unconventional neuroprotection against Ca2+ -dependent insults by metalloporphyrin catalytic antioxidants.
Topics: Animals; Antioxidants; Brain Ischemia; Calcium; Calcium Signaling; Catalysis; Cell Membrane; Cells, Cultured; Cerebral Cortex; Excitatory Amino Acid Agonists; Fluoresceins; Glutamic Acid; Metalloporphyrins; N-Methylaspartate; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; Rats; Reactive Oxygen Species; Sodium-Calcium Exchanger; TRPM Cation Channels | 2006 |
Synthesis and neuroprotective effects of serofendic acid analogues.
Topics: Animals; Cells, Cultured; Diterpenes; Glutamic Acid; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; Rats; Structure-Activity Relationship | 2006 |
Protective effects of ginsenoside Rg2 against glutamate-induced neurotoxicity in PC12 cells.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Apoptosis; Calcium; Calcium Channel Blockers; Calpain; Caspase 3; Cell Survival; Dose-Response Relationship, Drug; Gene Expression; Ginsenosides; Glutamic Acid; Lipid Peroxidation; Neuroprotective Agents; Neurotoxicity Syndromes; Nimodipine; Oxidative Stress; Panax; PC12 Cells; Peptide Fragments; Rats | 2007 |
Sphingosylphosphocholine effects on cultured astrocytes reveal mechanisms potentially involved in neurotoxicity in Niemann-Pick type A disease.
Topics: Animals; Apoptosis; Astrocytes; Cell Proliferation; Cells, Cultured; Cerebral Cortex; Fluorescent Dyes; Fura-2; Glutamic Acid; Hippocampus; Microscopy, Video; Necrosis; Nerve Degeneration; Neurotoxicity Syndromes; Niemann-Pick Disease, Type A; Phenotype; Phosphorylcholine; Rats; Rats, Sprague-Dawley; Sphingosine | 2007 |
Repair of glutamate-induced excitotoxic neuronal damage mediated by intracerebroventricular transplantation of neural stem cells in adult mice.
Topics: Animals; Cell Count; Disease Models, Animal; Embryo, Mammalian; Glutamic Acid; Injections, Intraventricular; Intermediate Filament Proteins; Mice; Mice, Inbred Strains; Nerve Tissue Proteins; Nestin; Neurons; Neurotoxicity Syndromes; Stem Cell Transplantation; Stem Cells; Time Factors | 2007 |
Alterations of striatal glutamate transmission in rotenone-treated mice: MRI/MRS in vivo studies.
Topics: Animals; Brain; Cell Death; Citric Acid Cycle; Energy Metabolism; Feedback; Glutamic Acid; Immunohistochemistry; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Inbred C57BL; Neostriatum; Neurotoxicity Syndromes; Oxidative Phosphorylation; Rotenone; Synaptic Transmission; Tyrosine 3-Monooxygenase; Uncoupling Agents | 2008 |
Anti-apoptotic therapy with a Tat fusion protein protects against excitotoxic insults in vitro and in vivo.
Topics: Animals; Apoptosis; bcl-X Protein; Cells, Cultured; Disease Models, Animal; Drug Interactions; Embryo, Mammalian; Gene Products, tat; Glutamic Acid; Hippocampus; Kainic Acid; Male; Neuroglia; Neurons; Neurotoxicity Syndromes; Rats; Rats, Sprague-Dawley; Recombinant Proteins | 2008 |
Pyridoxine may protect the cerebellar granular cells against glutamate-induced toxicity.
Topics: Animals; Cell Culture Techniques; Cerebellum; Dose-Response Relationship, Drug; Glutamic Acid; Neuroprotective Agents; Neurotoxicity Syndromes; Pyridoxine; Rats; Rats, Sprague-Dawley; Vitamin B Complex | 2007 |
Pyruvate and lactate protect striatal neurons against N-methyl-D-aspartate-induced neurotoxicity.
Topics: Adenosine Triphosphate; Animals; Calcium; Cells, Cultured; Cytosol; Energy Metabolism; Excitatory Amino Acid Agonists; Free Radical Scavengers; Glucose; Glutamic Acid; Glycolysis; Kinetics; Lactic Acid; Mice; Mitochondria; N-Methylaspartate; Neostriatum; Neurons; Neurotoxicity Syndromes; Oxygen Consumption; Pyruvic Acid | 1999 |
Lomerizine, a Ca2+ channel blocker, reduces glutamate-induced neurotoxicity and ischemia/reperfusion damage in rat retina.
Topics: Animals; Calcium Channel Blockers; Cells, Cultured; Dizocilpine Maleate; Dose-Response Relationship, Drug; Flunarizine; Glutamic Acid; Male; Neuroprotective Agents; Neurotoxicity Syndromes; Piperazines; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2000 |
Exploration of the role of reactive oxygen species in glutamate neurotoxicity in rat hippocampal neurones in culture.
Topics: Animals; Antioxidants; Calcium Signaling; Cell Survival; Cells, Cultured; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Homeostasis; Image Processing, Computer-Assisted; Membrane Potentials; Mitochondria; Neurons; Neurotoxicity Syndromes; Patch-Clamp Techniques; Rats; Reactive Oxygen Species | 2001 |