glutamic acid has been researched along with Diabetes Mellitus, Type 2 in 70 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (2.86) | 18.2507 |
| 2000's | 21 (30.00) | 29.6817 |
| 2010's | 31 (44.29) | 24.3611 |
| 2020's | 16 (22.86) | 2.80 |
| Authors | Studies |
|---|---|
| Abdellatif, AAH; Aldubayan, MA; Alhowail, AH; Almogbel, YS; Chigurupati, S; Nemala, RA | 1 |
| Bodnár, M; Caneva, E; Fazekas, E; Kerekes, K; Körhegyi, Z; Kovács-Kocsi, J; Nicotra, F; Pignatelli, C; Prépost, E; Rossi, L; Russo, L | 1 |
| Bi, Y; Chen, G; Chen, L; Chen, Y; Dai, M; Deng, H; Du, R; Gao, Z; Hu, C; Hu, R; Huo, Y; Lai, S; Li, D; Li, M; Li, Q; Lin, H; Liu, C; Liu, R; Lu, J; Luo, Z; Mu, Y; Ning, G; Qin, G; Qin, Y; Shen, F; Shi, L; Su, Q; Tang, X; Wan, Q; Wang, G; Wang, J; Wang, S; Wang, T; Wang, W; Wang, X; Wang, Y; Wu, S; Xu, G; Xu, M; Xu, Y; Yan, L; Yang, T; Ye, Z; Yu, X; Zhang, D; Zhang, Y; Zhao, J; Zhao, X; Zhao, Z; Zheng, R | 1 |
| Hosoe, S; Ishizaka, Y; Kageyama, Y; Katakami, N; Kawamori, D; Shimomura, I; Tanaka, T | 1 |
| Avgerinos, KI; Chen, Q; Egan, JM; Kapogiannis, D; Melvin, D; Mullins, RJ; Mustapic, M; Vreones, M | 1 |
| Caramelo, B; Castelhano, J; Castelo-Branco, M; Manadas, B; Martins, J; Matafome, P; Monteiro-Alfredo, T; Sereno, J | 1 |
| Fang, ZZ; Gao, XQ; Li, F; Li, RT; Li, Y; Wang, BW; Zhang, JX; Zhang, XY | 1 |
| Fukui, M; Hamaguchi, M; Hashimoto, Y; Kobayashi, A; Nakajima, H; Nakanishi, N; Okada, H; Okamura, T; Senmaru, T; Takahashi, F; Ushigome, E | 1 |
| Jang, HB; Kim, HJ; Koo, SK; Lee, HJ; Yeom, JW; Yoo, MG; Yun, JH | 1 |
| Azarbayjani, MA; Peeri, M; Shekarchian, M | 1 |
| Chen, Z; Doria, A; Hu, FB; Hu, Y; Manson, JE; Rimm, EB; Sun, Q | 1 |
| Andrade, PB; Neves, D; Rocha, L; Valentão, P; Videira, RA | 1 |
| Cho, J; Enya, M; Handa, H; Horikawa, Y; Imai, T; Imai, Y; Takeda, J | 1 |
| Castelo-Branco, M; d'Almeida, OC; Gomes, L; Moreno, C; Quendera, B; Violante, IR | 1 |
| Bararpour, N; Darrous, L; Froguel, P; Gasser, M; Gilardi, F; Kutalik, Z; Marques-Vidal, P; Porcu, E; Thomas, A; Waeber, G; Yengo, L | 1 |
| Chekkal, N; Hulea, L; Palia, R; Papadopoli, D; Pollak, M; St-Pierre, J; Topisirovic, I; Uchenunu, O | 1 |
| Bhaduri, G; Bhattacharya, B; Mondal, LK | 1 |
| Fernandez, C; Melander, O; Ottosson, F; Smith, E | 1 |
| Gao, J; Guo, Y; Ji, L; Li, J; Li, L; Liu, D; Liu, P; Pan, B; Pennathur, S; Su, J; Wang, Y; Willard, B; Xiang, S; Xu, L; Zhang, D; Zhao, M; Zheng, L | 1 |
| Hu, C; Jia, W; Jiang, F; Wang, J; Wang, S; Yan, D; Zhang, R; Zhao, A; Zheng, X | 1 |
| Kuusisto, J; Laakso, M; Smith, U; Stancáková, A; Vangipurapu, J | 1 |
| Arab-Bafrani, Z; Hashemi, MM; Marjani, A; Mousavi, E; Nezhadebrahimi, A | 1 |
| Bolo, NR; Fried, PJ; Pascual-Leone, A | 1 |
| Arós, F; Clish, C; Corella, D; Estruch, R; Fiol, M; Fito, M; Gómez-Gracia, E; Guasch-Ferré, M; Hu, FB; Lapetra, J; Liang, L; Liu, X; Martínez-González, MA; Papandreou, C; Razquin, C; Ros, E; Ruiz-Canela, M; Salas-Salvadó, J; Serra-Majem, L; Toledo, E; Zheng, Y | 1 |
| Lian, LY; Neocleous, V; Phelan, MM; Phylactou, LA; Shammas, C; Skordis, N | 1 |
| Andreozzi, F; Biolo, G; di Pietro, N; Doria, A; Formoso, G; Gervino, EV; Hauser, TH; Hu, F; Krolewski, AS; Mannino, GC; Mendonca, C; Muehlschlegel, JD; Niewczas, MA; Novelli, V; Pandolfi, A; Prudente, S; Qi, L; Qi, Q; Rimm, E; Sesti, G; Sturma, M; Trischitta, V | 1 |
| Bowden, DW; Cox, AJ | 1 |
| Affolter, A; Clanachan, AS; Hersberger, M; Lemieux, H; Lou, PH; Lucchinetti, E; Warren, BE; Zaugg, M; Zhang, L | 1 |
| Ekka, M; Jagannathan, NR; P, R; Pandey, RM; Sharma, U; Sinha, S | 1 |
| Du, J; He, T; Jiang, H; Qu, J; Song, Z; Wu, S | 1 |
| Datusalia, AK; Sharma, SS | 1 |
| Lammert, E; Otter, S | 1 |
| Brun, T; Maechler, P | 1 |
| Backes, WH; Edden, RAE; Hofman, PAM; Jansen, JFA; Puts, NAJ; Schram, MT; Stehouwer, CDA; van Boxtel, MPJ; van Bussel, FCG; Wildberger, JE | 1 |
| Arós, F; Clish, CB; Corella, D; Dennis, C; Estruch, R; Fiol, M; Fitó, M; Gómez-Gracia, E; Hruby, A; Hu, FB; Lapetra, J; Liang, L; Martínez-González, MA; Ros, E; Ruiz-Canela, M; Salas-Salvado, J; Serra-Majem, L; Toledo, E; Zheng, Y | 1 |
| Artunay, O; Simsek, IB | 1 |
| Osredkar, J; Petrovic, D; Petrovic, MG; Saraga-Babić, M | 1 |
| Arakaki, RF; Florez, JC; Goldstein, BJ; Hanson, RL; Jablonski, KA; Kahn, SE; Kitabchi, AE; Knowler, WC; Mason, CC; McAteer, JB; Moore, AF | 1 |
| Gao, H; Guo, Q; Liu, J; Ma, X; Shen, L; Shi, Z; Xu, S; Yuan, X; Zhang, J | 1 |
| Bøtker, HE; Kristiansen, SB; Løfgren, B; Nielsen, JM; Nielsen, TT; Nørregaard, R; Povlsen, JA; Rasmussen, LE | 1 |
| Anderson, CA; Anderson, EJ; Kypson, AP; Lehr, EJ; Neufer, PD; Rodriguez, E | 1 |
| Chen, X; Gong, ZC; Huang, Q; Liu, ZQ; Ren, HY; Sheng, FF; Wu, J; Xu, XJ; Yin, JY; Yu, M; Zhou, HH | 1 |
| Benie, AJ; Bouman, SD; Schousboe, A; Sickmann, HM; Waagepetersen, HS | 2 |
| Chen, Z; Feng, G; He, L; Liu, Y; Liu, Z; Xu, H; Yang, Y; Yu, L; Zhang, D; Zhang, Z; Zhao, T; Zhou, D | 1 |
| Alvelius, G; Jörnvall, H; Nerelius, C | 1 |
| Ataei, F; Bakhtiyari, S; Gerayesh-Nejad, S; Gulkho, S; Hanachi, P; Larijani, B; Meshkani, R; Mohammadi, M; Mohammadtaghvaei, N; Parvaneh, L; Saberi, H; Zargari, M | 1 |
| Andersen, JL; Dela, F; Hansen, CN; Helge, JW; Hey-Mogensen, M; Larsen, S; Madsbad, S; Stride, N; Worm, D | 1 |
| Davalli, AM; Folli, FB; Perego, C | 1 |
| Hernández, C; Simó, R | 1 |
| Manolopoulos, VG; Petridis, I; Ragia, G; Tavridou, A | 1 |
| Cai, S; Chen, Z; Dong, J; Feng, J; Li, X; Liu, C; Xu, J | 1 |
| Bailey, CJ; Flatt, PR; Gault, VA; Harriott, P; Mooney, MH; O'Harte, FP; Parker, JC | 1 |
| Colagiuri, S; Duarte, NL; Palu, T; Wang, XL; Wilcken, DE | 1 |
| Fernández Pérez, C; González Sánchez, JL; Martínez Larrad, MT; Palou, A; Proenza, AM; Ramis, JM; Serrano Ríos, M | 1 |
| Hermanussen, M; Tresguerres, JA | 1 |
| Almgren, P; Altshuler, D; Burtt, N; Daly, MJ; de Bakker, PI; Florez, JC; Gaudet, D; Groop, L; Hirschhorn, JN; Holmkvist, J; Hudson, TJ; Schaffner, SF; Tuomi, T | 1 |
| Dominic, EA; Ferrando, A; Raj, DS; Waters, D; Welbourne, T; Wolfe, R | 1 |
| Duarte, AI; Oliveira, CR; Santos, MS; Seiça, R | 1 |
| Attie, AD; Frey, BL; Gray-Keller, MP; Rabaglia, ME; Shortreed, MR; Smith, LM | 1 |
| Beck, SR; Bowden, DW; Burdon, KP; Freedman, BI; Langefeld, CD; Liu, Y; Rich, SS; Wagenknecht, LE | 1 |
| Kowluru, A; McDonald, P; Palanivel, R; Veluthakal, R | 1 |
| Ajilore, O; Binesh, N; Darwin, C; Haroon, E; Kumar, A; Kumaran, S; Miller, J; Mintz, J; Thomas, MA | 1 |
| Malaisse, WJ | 1 |
| Cai, H; Colagiuri, S; Wang, X; Wilcken, DE | 1 |
| Duarte, A; Resende de Oliveira, C; Santos, M; Seiça, R | 1 |
| Haas, OA; Muhr, D; Niederle, B; Scheuba, C; Schlegl, R; Vierhapper, H; Wagner, T; Weinhaeusel, A | 1 |
| Bengtsson, K; Groop, L; Lindblad, U; Melander, O; Orho-Melander, M; Ranstam, J; Råstam, L | 1 |
| Carlsson, M; Groop, LC; Hedenbro, J; Orho-Melander, M | 1 |
| Blaak, EE; Wagenmakers, AJ | 1 |
10 review(s) available for glutamic acid and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
The most effective polymorphisms of paraoxonase-1 gene on enzyme activity and concentration of paraoxonase-1 protein in type 2 diabetes mellitus patients and non-diabetic individuals: A systematic review and meta-analysis.
Topics: Amino Acid Substitution; Arginine; Aryldialkylphosphatase; Diabetes Mellitus, Type 2; Enzyme Activation; Female; Gain of Function Mutation; Genotype; Glutamic Acid; Humans; Leucine; Male; Methionine; Polymorphism, Genetic | 2019 |
A report of 2 new cases of MODY2 and review of the literature: implications in the search for type 2 diabetes drugs.
Topics: Arginine; Child; Codon, Nonsense; Congenital Hyperinsulinism; Diabetes Mellitus, Type 2; Female; Glucokinase; Glucose Tolerance Test; Glutamic Acid; Humans; Hypoglycemic Agents; Infant, Newborn; Mutation; Proline | 2013 |
Association between a genetic variant related to glutamic acid metabolism and coronary heart disease in individuals with type 2 diabetes.
Topics: Adult; Case-Control Studies; Chromosomes, Human, Pair 1; Coronary Disease; Diabetes Mellitus, Type 2; Female; Gene Expression Profiling; Genome-Wide Association Study; Genotype; Glutamate-Ammonia Ligase; Glutamic Acid; Glutamine; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Risk; United States | 2013 |
Exciting Times for Pancreatic Islets: Glutamate Signaling in Endocrine Cells.
Topics: Animals; Diabetes Mellitus, Type 2; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Models, Biological; Receptors, Glutamate; Second Messenger Systems; Secretory Vesicles | 2016 |
Beta-cell mitochondrial carriers and the diabetogenic stress response.
Topics: Animals; Citric Acid Cycle; Diabetes Mellitus, Type 2; Exocytosis; Fatty Acids; Glucose; Glutamic Acid; Homeostasis; Humans; Hyperglycemia; Insulin; Insulin Secretion; Insulin-Secreting Cells; Mammals; Mitochondria; Mitochondrial Membrane Transport Proteins; NAD; Oxidative Stress; Signal Transduction | 2016 |
The potential role of glutamate in the current diabetes epidemic.
Topics: Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Epidemics; Glutamic Acid; Homeostasis; Humans; Insulin-Secreting Cells | 2012 |
Neuroprotection in diabetic retinopathy.
Topics: Antibodies, Monoclonal, Humanized; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Disease Progression; Eye Proteins; Female; Glutamic Acid; Humans; Male; Microcirculation; Nerve Growth Factors; Neuroprotective Agents; Oxidative Stress; Renin-Angiotensin System; Retinal Neurons; Serpins; Vascular Endothelial Growth Factor A | 2012 |
Does the thrifty phenotype result from chronic glutamate intoxication? A hypothesis.
Topics: Animals; Diabetes Mellitus, Type 2; Female; Fetal Blood; Fetal Growth Retardation; Glutamic Acid; Humans; Metabolic Syndrome; Models, Biological; Phenotype; Pregnancy | 2003 |
Haplotype structure and genotype-phenotype correlations of the sulfonylurea receptor and the islet ATP-sensitive potassium channel gene region.
Topics: ATP-Binding Cassette Transporters; Chromosome Mapping; Diabetes Mellitus, Type 2; Genotype; Glutamic Acid; Haplotypes; Humans; Islets of Langerhans; Lysine; Models, Genetic; Phenotype; Polymorphism, Single Nucleotide; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Sulfonylurea Receptors | 2004 |
The esters of carboxylic nutrients as insulinotropic tools in non-insulin-dependent diabetes mellitus.
Topics: Animals; B-Lymphocytes; Diabetes Mellitus, Type 2; Esters; Glutamic Acid; Insulin; Insulin Secretion; Pancreatin | 1995 |
3 trial(s) available for glutamic acid and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Empagliflozin Induced Ketosis, Upregulated IGF-1/Insulin Receptors and the Canonical Insulin Signaling Pathway in Neurons, and Decreased the Excitatory Neurotransmitter Glutamate in the Brain of Non-Diabetics.
Topics: Alzheimer Disease; Blood Glucose; Brain; Diabetes Mellitus, Type 2; Female; Glutamic Acid; Humans; Insulin; Insulin-Like Growth Factor I; Insulin, Regular, Human; Ketosis; Middle Aged; Neurons; Neurotransmitter Agents; Placenta Growth Factor; Receptor, Insulin; Signal Transduction; Sodium-Glucose Transporter 2 Inhibitors | 2022 |
The association of ENPP1 K121Q with diabetes incidence is abolished by lifestyle modification in the diabetes prevention program.
Topics: Chromans; Combined Modality Therapy; Diabetes Mellitus, Type 2; Exercise Therapy; Female; Gene Frequency; Genetic Linkage; Genetic Predisposition to Disease; Glutamic Acid; Humans; Hypoglycemic Agents; Incidence; Lysine; Male; Metformin; Middle Aged; Phosphoric Diester Hydrolases; Polymorphism, Single Nucleotide; Pyrophosphatases; Risk Reduction Behavior; Thiazolidinediones; Troglitazone | 2009 |
KCNJ11 Lys23Glu and TCF7L2 rs290487(C/T) polymorphisms affect therapeutic efficacy of repaglinide in Chinese patients with type 2 diabetes.
Topics: Adult; Alleles; Amino Acid Substitution; Asian People; Blood Glucose; Carbamates; Diabetes Mellitus, Type 2; Female; Glutamic Acid; Humans; Lysine; Male; Middle Aged; Piperidines; Polymorphism, Genetic; Potassium Channels, Inwardly Rectifying; Risk Factors; TCF Transcription Factors; Transcription Factor 7-Like 2 Protein; Treatment Outcome | 2010 |
57 other study(ies) available for glutamic acid and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Effects of CMF and MET on glutamate and dopamine levels in the brain, and their impact on cognitive function.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain; Breast Neoplasms; Cognition; Cyclophosphamide; Diabetes Mellitus, Type 2; Dopamine; Female; Fluorouracil; Glutamic Acid; Humans; Metformin; Methotrexate; Rats | 2022 |
Multivalent γ-PGA-Exendin-4 Conjugates to Target Pancreatic β-Cells.
Topics: Diabetes Mellitus, Type 2; Exenatide; Glucagon-Like Peptide-1 Receptor; Glutamic Acid; Humans; Pancreatic Neoplasms; Peptides; Polyglutamic Acid; Radiopharmaceuticals | 2022 |
Amino acids, microbiota-related metabolites, and the risk of incident diabetes among normoglycemic Chinese adults: Findings from the 4C study.
Topics: 2-Aminoadipic Acid; Adult; Alanine; Amino Acids; Asparagine; Diabetes Mellitus, Type 2; Glutamic Acid; Histidine; Homoserine; Humans; Lipids; Methionine; Microbiota; Proline; Uric Acid | 2022 |
Characteristic changes in plasma glutamate levels and free amino acid profiles in Japanese patients with type 1 diabetes mellitus.
Topics: Amino Acids; Blood Glucose; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; East Asian People; Glucagon; Glutamic Acid; Humans; Insulin | 2023 |
Functional imaging and neurochemistry identify in vivo neuroprotection mechanisms counteracting excitotoxicity and neurovascular changes in the hippocampus and visual cortex of obese and type 2 diabetic animal models.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Models, Animal; Neurochemistry; Neuroprotection; Obesity; Rats; Visual Cortex | 2023 |
Relationship between plasma glutamate and cardiovascular disease risk in Chinese patients with type 2 diabetes mellitus by gender.
Topics: Blood Glucose; Cardiovascular Diseases; Diabetes Mellitus, Type 2; East Asian People; Female; Glutamic Acid; Humans; Male; Risk Factors | 2023 |
Leucine and Glutamic Acid as a Biomarker of Sarcopenic Risk in Japanese People with Type 2 Diabetes.
Topics: Biomarkers; Diabetes Mellitus, Type 2; Dietary Proteins; East Asian People; Glutamic Acid; Humans; Leucine; Muscle, Skeletal; Sarcopenia | 2023 |
Increased glutamate in type 2 diabetes in the Korean population is associated with increased plasminogen levels.
Topics: Animals; Cohort Studies; Diabetes Mellitus, Type 2; Genome-Wide Association Study; Glutamic Acid; Humans; Insulin Resistance; Mice; Plasminogen; Plasminogen Activator Inhibitor 1; Republic of Korea | 2023 |
Physical activity in a swimming pool attenuates memory impairment by reducing glutamate and inflammatory cytokines and increasing BDNF in the brain of mice with type 2 diabetes.
Topics: Animals; Body Weight; Brain; Brain-Derived Neurotrophic Factor; Cytokines; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucose; Glutamic Acid; Hippocampus; Insulin Resistance; Interleukin-6; Memory Disorders; Mice; Swimming; Swimming Pools; Tumor Necrosis Factor-alpha | 2023 |
Dietary Glutamine and Glutamate in Relation to Cardiovascular Disease Incidence and Mortality in the United States Men and Women with Diabetes Mellitus.
Topics: Adult; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diet; Female; Follow-Up Studies; Glutamic Acid; Glutamine; Humans; Incidence; Male; Proportional Hazards Models; Prospective Studies; United States | 2023 |
Adding value to polyvinylpolypyrrolidone winery residue: A resource of polyphenols with neuroprotective effects and ability to modulate type 2 diabetes-relevant enzymes.
Topics: Acetylcholinesterase; Aldehyde Reductase; Animals; Antioxidants; Cell Line; Diabetes Mellitus, Type 2; Glutamic Acid; Glycoside Hydrolase Inhibitors; GPI-Linked Proteins; Humans; Neuroprotective Agents; Neurotoxicity Syndromes; Oxidation-Reduction; Plant Extracts; Polyphenols; Povidone; Proanthocyanidins; Rats; Wine | 2020 |
L-Arginine prevents cereblon-mediated ubiquitination of glucokinase and stimulates glucose-6-phosphate production in pancreatic β-cells.
Topics: Adaptor Proteins, Signal Transducing; Arginine; Cell Line; Diabetes Mellitus, Type 2; Glucokinase; Glucose-6-Phosphate; Glutamic Acid; HEK293 Cells; Humans; Insulin Secretion; Insulin-Secreting Cells; Proteolysis; Signal Transduction; Ubiquitin-Protein Ligases; Ubiquitination | 2020 |
The neurometabolic profiles of GABA and Glutamate as revealed by proton magnetic resonance spectroscopy in type 1 and type 2 diabetes.
Topics: Aged; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Female; gamma-Aminobutyric Acid; Glucose; Glutamic Acid; Glycated Hemoglobin; Humans; Male; Middle Aged; Neurotransmitter Agents; Proton Magnetic Resonance Spectroscopy; Synaptic Transmission | 2020 |
Triangulating evidence from longitudinal and Mendelian randomization studies of metabolomic biomarkers for type 2 diabetes.
Topics: Adult; Aged; Betaine; Biomarkers; Carnitine; Case-Control Studies; Diabetes Mellitus, Type 2; Early Diagnosis; Female; Genetic Predisposition to Disease; Glutamic Acid; Humans; Leucine; Lysine; Male; Mannose; Mendelian Randomization Analysis; Metabolome; Middle Aged; Valine | 2021 |
Perturbations of cancer cell metabolism by the antidiabetic drug canagliflozin.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Canagliflozin; Cell Line, Tumor; Cell Proliferation; Cell Respiration; Citric Acid Cycle; Diabetes Mellitus, Type 2; Female; Glucose; Glutamate Dehydrogenase; Glutamic Acid; Humans; MCF-7 Cells; Mice; Mitochondria; Oxygen Consumption; RNA Interference; RNA, Small Interfering; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors | 2021 |
Biochemical scenario behind initiation of diabetic retinopathy in type 2 diabetes mellitus.
Topics: Adult; Biomarkers; Blood Glucose; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Enzyme-Linked Immunosorbent Assay; Female; Glutamic Acid; Glycation End Products, Advanced; Glycemic Index; Humans; Lactic Acid; Male; Malondialdehyde; Nitrates; Reactive Oxygen Species; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 | 2018 |
Altered Asparagine and Glutamate Homeostasis Precede Coronary Artery Disease and Type 2 Diabetes.
Topics: Aged; Aged, 80 and over; Asparagine; Case-Control Studies; Coronary Artery Disease; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Female; Follow-Up Studies; Glutamic Acid; Homeostasis; Humans; Male; Middle Aged; Prodromal Symptoms | 2018 |
Lysine glycation of apolipoprotein A-I impairs its anti-inflammatory function in type 2 diabetes mellitus.
Topics: Aged; Amino Acid Substitution; Analysis of Variance; Apolipoprotein A-I; Chromatography, Liquid; Diabetes Mellitus, Type 2; Glucose; Glutamic Acid; Glycosylation; Humans; Inflammation; Interleukin-1beta; Lipopolysaccharides; Lipoproteins, HDL; Lysine; Middle Aged; NF-kappa B; Protein Conformation; Protein Disulfide-Isomerases; Tandem Mass Spectrometry; THP-1 Cells; Tumor Necrosis Factor-alpha | 2018 |
Association between serum haptoglobin and carotid arterial functions: usefulness of a targeted metabolomics approach.
Topics: Adult; Aged; Aspartic Acid; Biomarkers; Carotid Artery Diseases; Carotid Intima-Media Thickness; Case-Control Studies; Diabetes Mellitus, Type 2; Enzyme-Linked Immunosorbent Assay; Female; Glutamic Acid; Haptoglobins; Humans; Male; Metabolomics; Middle Aged; Phosphatidylcholines | 2019 |
Nine Amino Acids Are Associated With Decreased Insulin Secretion and Elevated Glucose Levels in a 7.4-Year Follow-up Study of 5,181 Finnish Men.
Topics: Aged; Alanine; Amino Acids; Aspartic Acid; Blood Glucose; Diabetes Mellitus, Type 2; Finland; Follow-Up Studies; Glutamic Acid; Humans; Insulin Resistance; Insulin Secretion; Isoleucine; Leucine; Male; Metabolomics; Middle Aged; Phenylalanine; Risk Factors; Tryptophan; Tyrosine; Valine | 2019 |
Diabetes and the link between neuroplasticity and glutamate in the aging human motor cortex.
Topics: Aged; Aged, 80 and over; Aging; Aspartic Acid; Creatine; Diabetes Mellitus, Type 2; Female; Glucose; Glucose Intolerance; Glutamic Acid; Glutamine; Glutathione; Glycerylphosphorylcholine; Humans; Inositol; Insulin Resistance; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Cortex; Neuronal Plasticity; Phosphocreatine; Phosphorylcholine; Prediabetic State; Theta Rhythm; Transcranial Magnetic Stimulation | 2019 |
High plasma glutamate and low glutamine-to-glutamate ratio are associated with type 2 diabetes: Case-cohort study within the PREDIMED trial.
Topics: Aged; Aged, 80 and over; Biomarkers; Cardiovascular Diseases; Case-Control Studies; Diabetes Mellitus, Type 2; Diet, Healthy; Diet, Mediterranean; Female; Glutamic Acid; Glutamine; Humans; Incidence; Male; Middle Aged; Primary Prevention; Randomized Controlled Trials as Topic; Spain; Time Factors; Treatment Outcome | 2019 |
Diabetes: Unravelling the enigma of T2DM and cardiovascular disease.
Topics: Chromosomes, Human, Pair 1; Coronary Disease; Diabetes Mellitus, Type 2; Female; Glutamate-Ammonia Ligase; Glutamic Acid; Humans; Male | 2013 |
Early mitochondrial dysfunction in glycolytic muscle, but not oxidative muscle, of the fructose-fed insulin-resistant rat.
Topics: Aconitate Hydratase; Animals; Carnitine; Diabetes Mellitus, Type 2; Dietary Carbohydrates; Disease Progression; Energy Metabolism; Fatty Acids; Fructose; Glutamic Acid; Glycolysis; Insulin Resistance; Male; Mitochondria, Muscle; Muscle, Skeletal; Oxidative Phosphorylation; Prediabetic State; Pyruvate Dehydrogenase Complex; Pyruvic Acid; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species | 2014 |
Assessment of changes in brain metabolites in Indian patients with type-2 diabetes mellitus using proton magnetic resonance spectroscopy.
Topics: Aspartic Acid; Brain Chemistry; Choline; Creatinine; Diabetes Mellitus, Type 2; Glucose; Glutamic Acid; Glutamine; Humans; India; Inositol; Magnetic Resonance Spectroscopy; Pilot Projects; Prospective Studies; Protons; Tertiary Care Centers | 2014 |
Increased D-serine in the aqueous and vitreous humour in patients with proliferative diabetic retinopathy.
Topics: Aged; Aqueous Humor; Case-Control Studies; Chromatography, High Pressure Liquid; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Female; Glutamic Acid; Humans; Male; Middle Aged; Retinal Neovascularization; Retrospective Studies; Serine; Vitreous Body | 2014 |
NF-κB Inhibition Resolves Cognitive Deficits in Experimental Type 2 Diabetes Mellitus through CREB and Glutamate/GABA Neurotransmitters Pathway.
Topics: Animals; Avoidance Learning; Blood Glucose; Brain; Cognition Disorders; CREB-Binding Protein; Diabetes Mellitus, Type 2; Diet, High-Fat; Disease Models, Animal; Enzyme Inhibitors; gamma-Aminobutyric Acid; Glutamic Acid; Insulin; Male; Maze Learning; NF-kappa B; Nitriles; Rats; Rats, Sprague-Dawley; Recognition, Psychology; Signal Transduction; Sulfones | 2016 |
Increased GABA concentrations in type 2 diabetes mellitus are related to lower cognitive functioning.
Topics: Aged; Blood Glucose; Case-Control Studies; Cognition; Cognitive Dysfunction; Diabetes Mellitus, Type 2; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glycated Hemoglobin; Gray Matter; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neuropsychological Tests; White Matter | 2016 |
Metabolites of Glutamate Metabolism Are Associated With Incident Cardiovascular Events in the PREDIMED PREvención con DIeta MEDiterránea (PREDIMED) Trial.
Topics: Aged; Aged, 80 and over; Cardiovascular Diseases; Cholesterol, HDL; Cholesterol, LDL; Diabetes Mellitus, Type 2; Diet, Mediterranean; Dyslipidemias; Female; Glutamic Acid; Glutamine; Humans; Hypertension; Incidence; Male; Middle Aged; Myocardial Infarction; Proportional Hazards Models; Randomized Controlled Trials as Topic; Risk Factors; Smoking; Spain; Stroke; Tobacco Smoking | 2016 |
Evaluation of Biochemical Composition of Vitreous of Eyes of Diabetic Patients Using Proton Magnetic Resonance Spectroscopy.
Topics: Adult; Biomarkers; Creatine; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Female; Fluorescein Angiography; Fundus Oculi; Glutamic Acid; Humans; Lactic Acid; Male; Middle Aged; Proton Magnetic Resonance Spectroscopy; Reproducibility of Results; Retinal Vessels; Vitreous Body | 2017 |
K469E polymorphism of the intracellular adhesion molecule 1 gene is associated with proliferative diabetic retinopathy in Caucasians with type 2 diabetes.
Topics: Aged; Alanine; Case-Control Studies; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Female; Genetic Predisposition to Disease; Genotype; Glutamic Acid; Glycine; Humans; Intercellular Adhesion Molecule-1; Lysine; Male; Middle Aged; Polymorphism, Genetic; Slovenia; White People | 2008 |
Association of TRB3 gene Q84R polymorphism with type 2 diabetes mellitus in Chinese population.
Topics: Adult; Aged; Amino Acid Substitution; Arginine; Case-Control Studies; Cell Cycle Proteins; China; Diabetes Mellitus, Type 2; Female; Gene Frequency; Genetic Linkage; Genetics, Population; Glutamic Acid; Humans; Insulin Resistance; Male; Middle Aged; Polymorphism, Single Nucleotide; Protein Serine-Threonine Kinases; Repressor Proteins | 2009 |
Cardioprotective effect of L-glutamate in obese type 2 diabetic Zucker fatty rats.
Topics: Animals; Blotting, Western; Cardiotonic Agents; Diabetes Complications; Diabetes Mellitus, Type 2; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 3; Glutamic Acid; Hemodynamics; Male; Mitochondria, Heart; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Obesity; Perfusion; Polymerase Chain Reaction; Rats; Rats, Inbred WKY; Rats, Zucker; RNA, Messenger; Sarcolemma; Time Factors; Ventricular Function, Left | 2009 |
Substrate-specific derangements in mitochondrial metabolism and redox balance in the atrium of the type 2 diabetic human heart.
Topics: Adenosine Diphosphate; Adult; Cell Respiration; Citric Acid Cycle; Diabetes Mellitus, Type 2; Fatty Acids; Female; Glutamic Acid; Glutathione; Heart Atria; Heat-Shock Proteins; Humans; Hydrogen Peroxide; Kinetics; Male; Middle Aged; Mitochondria, Heart; Oxidative Stress; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; PPAR alpha; Transcription Factors; Triglycerides | 2009 |
Obesity and type 2 diabetes in rats are associated with altered brain glycogen and amino-acid homeostasis.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Blood Glucose; Brain; Diabetes Mellitus, Type 2; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Glycogen; Male; Obesity; Rats; Rats, Sprague-Dawley; Rats, Zucker | 2010 |
The ENPP1 K121Q polymorphism is not associated with type 2 diabetes or obesity in the Chinese Han population.
Topics: Aged; Amino Acid Substitution; Asian People; Diabetes Mellitus, Type 2; Female; Genetics, Population; Genome-Wide Association Study; Glutamic Acid; Humans; Lysine; Male; Middle Aged; Obesity; Phosphoric Diester Hydrolases; Polymorphism, Single Nucleotide; Pyrophosphatases | 2011 |
N-terminal segment of proinsulin C-peptide active in insulin interaction/desaggregation.
Topics: Amino Acid Sequence; C-Peptide; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Glutamic Acid; Humans; Insulin; Molecular Sequence Data | 2010 |
The ENPP1 K121Q polymorphism is not associated with type 2 diabetes and related metabolic traits in an Iranian population.
Topics: Adult; Aged; Amino Acid Substitution; Diabetes Mellitus, Type 2; Female; Gene Frequency; Genetic Predisposition to Disease; Genetics, Population; Genotype; Glutamic Acid; Humans; Insulin Resistance; Iran; Lysine; Male; Metabolic Diseases; Middle Aged; Phosphoric Diester Hydrolases; Polymorphism, Single Nucleotide; Pyrophosphatases; Young Adult | 2011 |
Increased mitochondrial substrate sensitivity in skeletal muscle of patients with type 2 diabetes.
Topics: Carnitine; Case-Control Studies; Cell Respiration; Citrate (si)-Synthase; Diabetes Mellitus, Type 2; Glutamic Acid; Humans; Insulin Resistance; Male; Middle Aged; Mitochondria, Muscle; Muscle, Skeletal; Myosin Heavy Chains; Obesity; Substrate Specificity; Succinic Acid; Superoxide Dismutase; Thinness | 2011 |
Brain glycogen and its role in supporting glutamate and GABA homeostasis in a type 2 diabetes rat model.
Topics: Animals; Aspartic Acid; Brain Chemistry; Cerebral Cortex; Diabetes Mellitus, Type 2; gamma-Aminobutyric Acid; Glucose; Glutamic Acid; Glycogen; Glycogen Phosphorylase; Homeostasis; Indoles; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Phenylbutyrates; Pyruvate Carboxylase; Pyruvate Dehydrogenase Complex; Rats; Rats, Sprague-Dawley; Rats, Zucker; Synaptic Transmission | 2012 |
Association of KCNJ11 E23K gene polymorphism with hypoglycemia in sulfonylurea-treated type 2 diabetic patients.
Topics: Adult; Aged; Alleles; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C9; Diabetes Mellitus, Type 2; Female; Genotype; Gliclazide; Glutamic Acid; Glycated Hemoglobin; Greece; Humans; Hypoglycemia; Lysine; Male; Middle Aged; Polymerase Chain Reaction; Polymorphism, Genetic; Potassium Channels, Inwardly Rectifying; Sulfonylurea Compounds | 2012 |
Metabolomic profilings of urine and serum from high fat-fed rats via 1H NMR spectroscopy and pattern recognition.
Topics: 3-Hydroxybutyric Acid; Animals; Choline; Citric Acid; Creatinine; Diabetes Mellitus, Type 2; Dietary Fats; Glutamic Acid; Glutamine; Hippurates; Lactic Acid; Magnetic Resonance Spectroscopy; Metabolomics; Obesity; Rats; Taurine | 2013 |
Improved stability, insulin-releasing activity and antidiabetic potential of two novel N-terminal analogues of gastric inhibitory polypeptide: N-acetyl-GIP and pGlu-GIP.
Topics: Acetylation; Animals; Area Under Curve; Biotransformation; Blood Glucose; Cell Line; Cricetinae; Cricetulus; Cyclic AMP; Diabetes Mellitus, Type 2; Fibroblasts; Gastric Inhibitory Polypeptide; Glutamic Acid; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Lung; Mice; Mice, Obese; Receptors, Gastrointestinal Hormone; Recombinant Proteins; Structure-Activity Relationship; Transfection | 2002 |
Obesity, Type II diabetes and the beta 2 adrenoceptor gene Gln27Glu polymorphism in the Tongan population.
Topics: Adult; Blood Glucose; Body Constitution; Body Mass Index; Diabetes Mellitus, Type 2; Female; Gene Frequency; Genetic Predisposition to Disease; Genetics, Population; Genotype; Glutamic Acid; Glutamine; Humans; Male; Middle Aged; Obesity; Polymorphism, Genetic; Receptors, Adrenergic, beta-2; Tonga | 2003 |
The glutamine 27 glutamic acid polymorphism of the beta2-adrenoceptor gene is associated with abdominal obesity and greater risk of impaired glucose tolerance in men but not in women: a population-based study in Spain.
Topics: Adult; Blood Glucose; Body Constitution; Body Mass Index; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Genotype; Glucose Tolerance Test; Glutamic Acid; Glutamine; Humans; Insulin; Leptin; Male; Middle Aged; Obesity; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Receptors, Adrenergic; Receptors, Adrenergic, beta-2; Sex Factors | 2003 |
Glutamine kinetics and protein turnover in end-stage renal disease.
Topics: Adult; Alanine; Arteries; Diabetes Mellitus, Type 2; Female; Glutamic Acid; Humans; Kidney Failure, Chronic; Male; Middle Aged; Models, Biological; Muscle, Skeletal; Phenylalanine; Proteins; Renal Dialysis; Veins | 2005 |
Oxidative stress affects synaptosomal gamma-aminobutyric acid and glutamate transport in diabetic rats: the role of insulin.
Topics: Animals; Biological Transport; Cerebral Cortex; Diabetes Mellitus, Type 2; gamma-Aminobutyric Acid; Glutamic Acid; Insulin; Lipid Peroxidation; Male; Oxidation-Reduction; Oxidative Stress; Rats; Rats, Mutant Strains; Rats, Wistar; Synaptosomes; Thiobarbituric Acid Reactive Substances | 2004 |
Alpha-Ketoisocaproate-induced hypersecretion of insulin by islets from diabetes-susceptible mice.
Topics: Animals; Cells, Cultured; Diabetes Mellitus, Type 2; Disease Models, Animal; Glutamate Dehydrogenase; Glutamic Acid; Hyperinsulinism; Insulin; Insulin Resistance; Insulin Secretion; Islets of Langerhans; Keto Acids; Ketoglutaric Acids; Leptin; Mice; Mice, Inbred C57BL; Mice, Transgenic; Species Specificity; Transaminases | 2005 |
T-786C polymorphism of the endothelial nitric oxide synthase gene is associated with albuminuria in the diabetes heart study.
Topics: Aged; Albuminuria; Aspartic Acid; Creatinine; Cysteine; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Exons; Female; Genetic Predisposition to Disease; Genotype; Glutamic Acid; Homozygote; Humans; Linkage Disequilibrium; Male; Middle Aged; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Odds Ratio; Polymorphism, Genetic; Promoter Regions, Genetic; Threonine | 2005 |
Further evidence for the regulation of acetyl-CoA carboxylase activity by a glutamate- and magnesium-activated protein phosphatase in the pancreatic beta cell: defective regulation in the diabetic GK rat islet.
Topics: Acetyl-CoA Carboxylase; Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; Enzyme Activation; Enzyme Inhibitors; Glutamic Acid; Islets of Langerhans; Magnesium; Male; Okadaic Acid; Phosphoprotein Phosphatases; Rats; Rats, Sprague-Dawley; Rats, Wistar | 2005 |
Measurement of brain metabolites in patients with type 2 diabetes and major depression using proton magnetic resonance spectroscopy.
Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain Chemistry; Choline; Creatine; Depressive Disorder, Major; Diabetes Complications; Diabetes Mellitus, Type 2; Female; Glutamic Acid; Glutamine; Humans; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Prefrontal Cortex; Psychiatric Status Rating Scales | 2007 |
A common Glu298-->Asp (894G-->T) mutation at exon 7 of the endothelial nitric oxide synthase gene and vascular complications in type 2 diabetes.
Topics: Albuminuria; Amino Acid Substitution; Angina Pectoris; Aspartic Acid; Cerebrovascular Disorders; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic Nephropathies; Diabetic Neuropathies; Diabetic Retinopathy; Exons; Genotype; Glutamic Acid; Humans; Middle Aged; Myocardial Infarction; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Peripheral Vascular Diseases; Point Mutation; Risk Factors | 1998 |
Effect of oxidative stress on the uptake of GABA and glutamate in synaptosomes isolated from diabetic rat brain.
Topics: Animals; Ascorbic Acid; Blood Glucose; Body Weight; Brain; Diabetes Mellitus, Type 2; Disease Models, Animal; gamma-Aminobutyric Acid; Glucose; Glutamic Acid; Glycated Hemoglobin; Lipid Peroxidation; Male; Oxidative Stress; Rats; Rats, Inbred Strains; Synaptosomes; Tritium | 2000 |
A novel mutation E179K of the MEN1 gene predisposes for multiple endocrine neoplasia-type 1 (MEN1).
Topics: Adenoma; Adolescent; Adult; Amino Acid Substitution; Diabetes Mellitus, Type 2; Genetic Predisposition to Disease; Glutamic Acid; Humans; Hyperinsulinism; Hyperparathyroidism; Insulinoma; Lysine; Male; Multiple Endocrine Neoplasia Type 1; Mutation, Missense; Nuclear Family; Pancreatic Neoplasms | 2000 |
Beta(2)-adrenergic receptor gene variation and hypertension in subjects with type 2 diabetes.
Topics: Aged; Analysis of Variance; Arginine; Case-Control Studies; Diabetes Mellitus, Type 2; Female; Genetic Variation; Genotype; Glutamic Acid; Glutamine; Glycine; Humans; Hypertension; Male; Middle Aged; Polymorphism, Genetic; Receptors, Adrenergic, beta-2 | 2001 |
Common variants in the beta2-(Gln27Glu) and beta3-(Trp64Arg)--adrenoceptor genes are associated with elevated serum NEFA concentrations and type II diabetes.
Topics: Alleles; Amino Acid Substitution; Arginine; Blood Glucose; Blood Pressure; Cholesterol, HDL; Diabetes Mellitus, Type 2; Fatty Acids, Nonesterified; Female; Genetic Variation; Genotype; Glutamic Acid; Glutamine; Homozygote; Humans; Insulin; Male; Middle Aged; Nuclear Family; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Receptors, Adrenergic, beta-2; Receptors, Adrenergic, beta-3; Reference Values; Sweden; Triglycerides; Tryptophan; White People | 2001 |
The fate of [U-(13)C]palmitate extracted by skeletal muscle in subjects with type 2 diabetes and control subjects.
Topics: Adrenergic beta-Agonists; Arteries; Blood Flow Velocity; Carbon Dioxide; Carbon Isotopes; Diabetes Mellitus, Type 2; Glucose; Glutamic Acid; Glutamine; Humans; Infusions, Intravenous; Isoproterenol; Liver; Male; Middle Aged; Muscle, Skeletal; Oxidation-Reduction; Palmitic Acid | 2002 |