glutamic acid has been researched along with Depression, Involutional in 176 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 31 (17.61) | 29.6817 |
| 2010's | 104 (59.09) | 24.3611 |
| 2020's | 41 (23.30) | 2.80 |
| Authors | Studies |
|---|---|
| Abdel-Bakky, MS; Abdellatif, AAH; Amin, E; Faris, TM | 1 |
| Chowdhury, KAA; Islam, MN; Tasnim, FM; Tayab, MA | 1 |
| Adamson, MM; Hadipour, AL; Kazemi, R; Luttenbacher, I; Martinez, J; Phillips, A; Sanghvi, I | 1 |
| Baker, G; Burgess, D; Ghuman, A; Hanstock, C; Jhangri, G; Le Melledo, JM; McEwen, A; Mitchell, N; Seres, P; Tran, KH | 1 |
| Cai, H; Cao, T; Chen, Q; Jiao, S; Wang, L; Wu, X; Yang, C; Yang, D; Yang, P; Zeng, C; Zhang, S; Zhu, Z | 1 |
| Barredo, J; Carpenter, LL; Fukuda, AM; Gonsalves, MA; Harris, AD; Joyce, HE; White, TL | 1 |
| Barbini, B; Benedetti, F; Bravi, B; Dallaspezia, S; Melloni, EMT; Poletti, S; Zanardi, R | 1 |
| Aust, S; Bajbouj, M; Gärtner, M; Grimm, S; Henning, A; Herrera-Melendez, A; Scheidegger, M; Seifritz, E; Stippl, A; Weigand, A; Wyss, PO | 1 |
| Allauze, E; Chabert, J; Chassain, C; De Chazeron, I; Fossati, P; Llorca, PM; Pereira, B; Rotgé, JY; Samalin, L | 1 |
| Ban, M; He, J; Kong, L; Wang, D; Xiao, Q; Yuan, F; Zhu, X | 1 |
| Buchmann, A; Ghisleni, C; Hasler, G; Haynes, M; Müller, ST; Noeske, R; Ritter, C; Tuura, R; Volleberg, M | 1 |
| Liang, K; Shen, JF; Wang, KL; Wang, LJ; Wang, XZ; Wang, Y; Wang, YY; Zhang, SX; Zhu, GH | 1 |
| Ching, J; Ho, CSH; Tay, GWN; Wee, HN | 1 |
| Chu, T; Dong, Y; Li, X; Liu, Q; Luo, X; Ren, Q; Wang, J; Xu, D; Zeng, Z; Zou, L | 1 |
| Candee, R; DeCenzo, M; Schreiber, M; Wilkenson, R | 1 |
| Menard, C; Paton, SE | 1 |
| Costa, B; Vale, N | 1 |
| Colle, R; Corruble, E; David, DJ; Defaix, C; Doan, J; Gardier, AM; Guilloux, JP; McGowan, JC; Mendez-David, I; Tritschler, L | 1 |
| Pavlova, I; Ruda-Kucerova, J | 1 |
| Boeker, H; Ernst, J; Grimm, S; Lehmann, M; Richter, A; Seifritz, E; Wade-Bohleber, L; Zoelch, N | 1 |
| Hirjak, D; Hu, YT; Northoff, G; Tan, ZL | 1 |
| Czechowska, E; Pańczyszyn-Trzewik, P; Sowa-Kućma, M; Stachowicz, K | 1 |
| Gardier, AM; Guilloux, JP; Nguyen, TML | 1 |
| De Berardis, D; Di Giannantonio, M; Fornaro, M; Fraticelli, S; Kim, YK; Martinotti, G; Orsolini, L; Perna, G; Pompili, M; Serafini, G; Tomasetti, C; Valchera, A; Vellante, F; Volpe, U | 1 |
| Artigas, F; Bortolozzi, A; Castañé, A; Fullana, N; Gasull-Camós, J; Tarrés-Gatius, M | 1 |
| de Diego-Adeliño, J; Draganov, M; Portella, MJ; Puigdemont, D; Vicent-Gil, M; Vives-Gilabert, Y | 1 |
| Armant, RJ; Bolaños-Guzmán, CA; Kokane, SS; Perrotti, LI | 1 |
| Kakanakova, A; Maes, M; Popov, S | 1 |
| Atalay, S; Cummings, A; Ding, XQ; Frieling, H; Kahl, KG; Lanfermann, H; Maudsley, AA; Schmitz, B; Sheriff, S | 1 |
| Davoudian, PA; Wilkinson, ST | 1 |
| Baer, L; Benson, KL; Bottary, R; Eric Jensen, J; Gonenc, A; Schoerning, L; Winkelman, JW | 1 |
| Cooper, TB; Dong, Z; Grunebaum, MF; Kegeles, LS; Keilp, JG; Lin, X; Mann, JJ; Mao, X; Milak, MS; Mulhern, ST; Ogden, RT; Rashid, R; Shungu, DC; Suckow, RF | 1 |
| Barker, PB; Edden, RAE; Gould, NF; Joo, JH; Kraut, MA; Leoutsakos, JS; Nassery, N; Oeltzschner, G; Rowland, LM; Smith, GS; Wijtenburg, SA; Workman, CI | 1 |
| Quevedo, J; Sanches, M; Soares, JC | 1 |
| Guiard, BP; Portal, B | 1 |
| Cheng, PZ; Duncan, NW; Hsu, TY; Lane, TJ; Lee, HC; Truong, V | 1 |
| Aydin, B; Ermis, C; Kucukguclu, S; Renshaw, PF; Yildiz, A; Yurt, A | 1 |
| Henter, ID; Park, LT; Zarate, CA | 1 |
| Barrick, EM; Cole, DJ; Cooper, JA; DeVries, BAM; Du, F; Hahn, EC; Hossein, S; Jensen, JE; Lawlor, VM; Leonard, CV; Nuutinen, MR; Ongur, D; Pizzagalli, DA; Shields, GS; Slavich, GM; Teer, AP; Treadway, MT | 1 |
| Aryutova, K; Kandilarova, S; Paunova, R; Stoyanov, D; Todeva-Radneva, A | 1 |
| Flais, I; Lazarevic, V; Svenningsson, P; Yang, Y | 1 |
| Blennow, K; Bruno, D; Cooper, TB; Hashimoto, K; Marmar, CR; Nierenberg, J; Pomara, N; Zetterberg, H | 1 |
| Asara, JM; Dournes, C; Filiou, MD; Ising, M; Müller, MB; Park, DI; Sillaber, I; Turck, CW; Webhofer, C | 1 |
| Abdallah, CG; Carson, RE; DellaGioia, N; DeLorenzo, C; Esterlis, I; Krystal, JH; Matuskey, D; Nabulsi, N; Parsey, RV; Pietrzak, RH; Pittenger, C; Sanacora, G; Yang, J | 1 |
| Chen, JX; Ding, XF; Jiao, HY; Li, YH; Sun, LJ; Wang, XX; Zhou, Y | 1 |
| de Moura, AB; Quevedo, J; Resende, WR; Reus, GZ; Silva, RH | 1 |
| Meyer, JH | 2 |
| Bradley, KA; Gabbay, V; Kang, G; Mao, X; Ostrover, R; Shungu, DC | 1 |
| Cowen, PJ; Emir, UE; Godlewska, BR; Masaki, C; Sharpley, AL | 1 |
| Liu, L; Pu, J; Xie, P; Yang, L; Yuan, S; Zhang, H; Zhang, Y; Zhao, L; Zhou, C; Zhou, X | 1 |
| Artigas, F; Bortolozzi, A; Celada, P | 1 |
| Arnone, D; Cappello, F; Cleare, AJ; Gammazza, AM; Herane-Vives, A; Lythgoe, DJ; Taylor, MJ; Williams, SC; Wise, T; Young, AH | 1 |
| Hara, A; Okubo, T; Osone, F; Shirayama, Y; Takahashi, M | 1 |
| Ballard, ED; Farmer, C; Henn, FA; Henter, ID; Kadriu, B; Lener, MS; Niciu, MJ; Nugent, AC; Park, LT; Park, M; Yazdian, A; Yuan, S; Zarate, CA | 1 |
| Bai, YM; Chen, MH; Huang, MH; Li, CT; Liu, RS; Su, TP; Tu, PC; Yang, BH | 1 |
| Gilbert, JR; Nugent, AC; Wills, KE; Yarrington, JS; Zarate, CA | 1 |
| An, L; Banerjee, D; Evans, JW; Lally, N; Li, N; Nugent, AC; Roiser, JP; Shen, J; Snider, SL; Zarate, CA | 1 |
| Forman, J; Kessing, LV; Knorr, U; Pech, J | 1 |
| Chea, W; Gardner, AC; Godfrey, KEM; Kwon, S; Muthukumaraswamy, SD | 1 |
| Chen, X; Felger, JC; Haroon, E; Hu, XP; Li, Z; Miller, AH; Patel, T; Woolwine, BJ | 1 |
| Blumberger, DM; Daskalakis, ZJ; ElSalhy, M; Graff-Guerrero, A; Horita, N; Katayama, N; Kishimoto, T; Meyer, JH; Mimura, M; Miyazaki, T; Moriguchi, S; Nakajima, S; Noda, Y; Ogyu, K; Plitman, E; Sano, Y; Takamiya, A; Tarumi, R; Tsugawa, S; Wada, M | 1 |
| Bellomo, A; Berardis, DD; Carano, A; Fiengo, ALC; Fornaro, M; Giannantonio, MD; Kim, YK; Martinotti, G; Montemitro, C; Nicola, MD; Orsolini, L; Perna, G; Pompili, M; Santone, C; Serafini, G; Tomasetti, C; Valchera, A; Vellante, F; Ventriglio, A | 1 |
| Duman, RS; Fogaça, MV; Hare, B; Shinohara, R | 1 |
| Backlund, L; Biernacka, JM; Bond, DJ; Choi, DS; Frye, MA; Geske, JR; Ho, AM; Jia, YF; Lavebratt, C; McElroy, SL; Millischer, V; Port, JD; Schalling, M; Skime, M; Veldic, M; Villaescusa, JC | 1 |
| Colic, L; Demenescu, LR; Denzel, D; Frommer, J; Kaufmann, J; Li, M; Lison, S; Lord, AR; Martens, L; Speck, O; Vogel, M; von Düring, F; Walter, M | 1 |
| Brechbühl, S; Buchmann, A; Ghisleni, C; Hasler, G; Haynes, M; Müller, ST; Tuura, R | 1 |
| Álvarez, E; de Diego-Adeliño, J; Gómez-Ansón, B; López-Moruelo, O; Pérez, V; Pérez-Egea, R; Portella, MJ; Puigdemont, D; Serra-Blasco, M; Vives, Y | 1 |
| Ionescu, DF; Niciu, MJ; Richards, EM; Zarate, CA | 1 |
| Chen, LP; Dai, HY; Dai, ZZ; Wu, RH; Xu, CT | 1 |
| Li, J; Miao, Z; Qian, X; Ren, L; Sun, M; Xu, X; Zhai, L | 1 |
| Bao, AM; Fu, XY; Jiang, Y; Li, HC; Lin, Z; Liu, WB; Lu, YR; Luo, JH; Shi, LG; Wang, ZP; Weng, XJ; Wu, JL; Wu, XY | 1 |
| Damji, O; Fife, M; Jaworska, N; Keess, J; Kirton, A; Langevin, LM; Lebel, RM; Liu, I; MacMaster, FP; Pradhan, S; Rajapakse, T; Sembo, M; Wilkes, TC; Yang, XR | 1 |
| Abdallah, CG; De Feyter, HM; Fasula, M; Jiang, L; Krystal, JH; Mason, GF; Rothman, DL; Sanacora, G | 1 |
| Cowen, PJ; Godlewska, BR; Near, J | 1 |
| Taylor, MJ | 1 |
| Earnheart, JC; Kim, JY; Lal, R; Luellen, BA; Luscher, B; Murakami, S; Ren, Z; Sahir, N; Song, H | 1 |
| Abdallah, CG; Black, A; Fasula, MK; Fenton, LR; Jiang, L; Mason, GF; Niciu, MJ; Rothman, DL; Sanacora, G | 1 |
| Borchardt, V; Dou, W; Genz, A; He, H; Heinze, HJ; Krause, AL; Li, M; Li, W; Lord, A; Metzger, CD; Safron, A; van Tol, MJ; Walter, M | 1 |
| Abdallah, CG; Duman, RS; Krystal, JH; Sanacora, G | 1 |
| Deakin, JFW; Dutta, A; McKie, S | 1 |
| Hillhouse, TM; Porter, JH | 1 |
| Pehrson, AL; Sanchez, C | 1 |
| Beck, J; Borgwardt, S; Deutschenbaur, L; Hasler, G; Kiyhankhadiv, A; Lang, UE; Mühlhauser, M; Sollberger, D; Walter, M | 1 |
| Bond, DJ; Lim, KO | 1 |
| Dalla, C; Ferreira, C; Kokras, N; Melo, A; Pêgo, JM; Sousa, N; Ventura-Silva, AP | 1 |
| Deep-Soboslay, A; Gray, AL; Hyde, TM; Kleinman, JE; Sodhi, MS | 1 |
| Hall, BJ; Miller, OH; Moran, JT | 1 |
| Chitty, KM; Haber, PS; Hermens, DF; Hickie, IB; Lagopoulos, J; Lee, RS; Naismith, SL; Tickell, A | 1 |
| Cooper, TB; Kegeles, LS; Keilp, JG; Mann, JJ; Mao, X; Milak, MS; Mulhern, ST; Ogden, RT; Oquendo, MA; Parter, AL; Proper, CJ; Rodriguez, CI; Shungu, DC; Suckow, RF | 1 |
| Hamazaki, K; Hamazaki, T; Hashimoto, K; Matsuoka, Y; Nishi, D; Noguchi, H | 1 |
| Mlyniec, K | 1 |
| Cui, S; Wang, JH; Xu, A | 1 |
| Compte, A; Mayberg, HS; Ramirez-Mahaluf, JP; Roxin, A | 1 |
| Croarkin, PE; Frye, MA; Murphy, LL; Nakonezny, PA; Port, JD; Sampson, SM; Wall, CA | 1 |
| Chen, X; Felger, JC; Fleischer, CC; Haroon, E; Hu, XP; Miller, AH; Patel, T; Woolwine, BJ | 1 |
| Chen, MH; Hong, CJ; Li, CT; Lin, WC; Liu, RS; Su, TP; Tu, PC; Yang, BH | 1 |
| Duman, RS; Gerhard, DM; Wohleb, ES | 1 |
| Arango, V; Burke, A; Dwork, AJ; Galfalvy, H; Huang, YY; Mann, JJ; Oquendo, MA; Pantazatos, SP; Rosoklija, GB; Yin, H | 1 |
| Banerjee, S; Dubin, MJ; Goodman, Z; Kang, G; Lapidus, KA; Liston, C; Mao, X; Shungu, DC | 1 |
| Blennow, K; Bruno, D; Hashimoto, K; Marmar, CR; Nierenberg, J; Pomara, N; Zetterberg, H | 1 |
| Fuchs, T; Jefferson, SJ; Luscher, B; Pribiag, H; Ren, Z; Shorey, M; Stellwagen, D | 1 |
| Li, Y; Maletic-Savatic, M; Sheng, J; Tang, Y; Tong, S; Wang, J; Zhang, T; Zhang, X; Zhu, Y | 1 |
| Sanacora, G | 1 |
| Bechara, A; Ding, Y; Jollant, F; Near, J; Richard-Devantoy, S; Turecki, G | 1 |
| Pałucha-Poniewiera, A; Pilc, A | 1 |
| Ballard, ED; Lener, MS; Niciu, MJ; Nugent, AC; Park, LT; Park, M; Zarate, CA | 1 |
| Christiansen, SH; Elbrønd-Bek, H; Lavebratt, C; Liu, JJ; Mathé, AA; Melas, PA; Villaescusa, JC; Wegener, G; Wei, YB; Woldbye, DP; Xu, N | 1 |
| Biswal, B; Colic, L; Demenescu, LR; Li, M; Li, S; Metzger, CD; Safron, A; Walter, M | 1 |
| Caberlotto, L; Carboni, L; Nguyen, TP | 1 |
| Bottrel, N; Corum, DG; Drevets, WC; Fiehn, O; Kaddurah-Daouk, R; Motsinger-Reif, A; Rotroff, DM; Salvadore, G; Singh, J | 1 |
| Harris, AD; Jasaui, Y; Jaworska, N; Kirton, A; Langevin, LM; Lebel, RM; Lefebvre, D; MacMaster, FP; Sembo, M; Swansburg, R; Wilkes, TC | 1 |
| Abdallah, CG; Coplan, JD; Gupta, S; Jackowski, A; Mao, X; Mathew, SJ; Salas, R; Sato, JR; Shungu, DC | 1 |
| Abdallah, CG; Mathew, SJ; Murrough, JW | 1 |
| Auer, DP; Murck, H; Schmid, D; Schubert, MI; Schüssler, P; Steiger, A | 1 |
| Block, W; Jessen, F; Maier, W; Metten, M; Schild, H; Träber, F; von Widdern, O; Zobel, A | 1 |
| Charney, DS; Collins, KA; Kelly, C; Mao, X; Mathew, SJ; Murrough, JW; Nestadt, P; Price, RB; Shungu, DC | 1 |
| Hall, GB; MacQueen, GM; Milne, A; Soreni, N; Yucel, K | 1 |
| Beck, J; Boeker, H; Boesiger, P; Dydak, U; Grimm, S; Henning, A; Northoff, G; Schnepf, B; Schulte, RF; Walter, M | 1 |
| András, S | 1 |
| Cowen, PJ; Jezzard, P; Murphy, S; Norbury, R; Rudebeck, S; Taylor, MJ | 1 |
| Hashimoto, K | 2 |
| Benkelfat, C; Bunney, WE; Ernst, C; Gratton, A; Klempan, T; Lebel, V; Mamdani, F; Mechawar, N; Rehal, S; Rouleau, GA; Sequeira, A; Turecki, G; Vawter, MP | 1 |
| Baker, GB; Mitchell, ND | 1 |
| Carpenter, LL; Philip, NS; Price, LH; Tyrka, AR | 1 |
| Akil, H; Barchas, JD; Bernard, R; Bunney, WE; Jones, EG; Kerman, IA; Myers, RM; Schatzberg, AF; Thompson, RC; Watson, SJ | 1 |
| Bevacqua, MG; Fontana, M; Salustri, C; Squitti, R; Tecchio, F; Ventriglia, M; Zappasodi, F | 1 |
| Austin, MC; Chandran, A; Feyissa, AM; Iyo, AH; Karolewicz, B; Regunathan, S | 1 |
| Andrade, G; Collins, KA; Kelly, C; Levine, SM; Mao, X; Mathew, SJ; Murrough, JW; Nestadt, P; Shungu, DC | 1 |
| Cowen, PJ; Mannie, ZN; Near, J; Norbury, R; Taylor, MJ | 1 |
| de Diego-Adeliño, J; Gómez-Ansón, B; Morgan-Ferrando, R; Pérez, V; Pérez-Egea, R; Portella, MJ; Puigdemont, D; Ruscalleda, J; Vives, Y | 1 |
| Bajbouj, M; Brakemeier, EL; Grimm, S; Heuser, I; Luborzewski, A; Merkl, A; Quante, A; Schubert, F | 1 |
| Fasula, M; Gomez, R; Krystal, JH; Mason, GF; Pittman, B; Sanacora, G; Valentine, GW; Watzl, J | 1 |
| Cowen, PJ; Mhuircheartaigh, RN; Taylor, MJ; Tiangga, ER | 1 |
| Bakker, SC; Boks, MP; Kahn, RS; Laban, KG; Luykx, JJ; Mandl, RC; van den Heuvel, MP | 1 |
| Bernstein, HG; Bogerts, B; Gos, T; Myint, AM; Sarnyai, Z; Steiner, J; Walter, M | 1 |
| Rowland, LM | 1 |
| Bernstein, HG; Bielau, H; Bogerts, B; Brisch, R; Gos, T; Guillemin, GJ; Mawrin, C; Meyer zu Schwabedissen, L; Myint, AM; Sarnyai, Z; Steiner, J; Walter, M | 1 |
| Baumann, J; Drevets, WC; Ibrahim, LA; Luckenbaugh, DA; Machado-Vieira, R; Marenco, S; Salvadore, G; Shen, J; van der Veen, JW; Zarate, CA; Zhang, Y | 1 |
| Lai, CH; Lane, HY; Tsai, GE | 1 |
| Bao, AM; Kamphuis, W; Lou, JS; Luchetti, S; Qi, XR; Swaab, DF; Zhao, J | 1 |
| Alger, JR; Espinoza, RT; Narr, KL; Phillips, OR; Woods, RP; Zhang, J | 1 |
| Dome, P; Faludi, G; Gonda, X; Weizman, S | 1 |
| Henter, ID; Mathews, DC; Zarate, CA | 1 |
| Garakani, A; Gorman, JM; Martinez, JM; Yehuda, R | 1 |
| Drago, A; Fabbri, C; Serretti, A | 1 |
| Musazzi, L; Popoli, M; Treccani, G | 1 |
| Boomsma, DI; Byrne, EM; Haddad, S; Heath, AC; Jung, JY; Lee, PH; Madden, PA; Martin, NG; Mayerfeld, CE; Penninx, BW; Pergadia, ML; Perlis, RH; Purcell, SM; Rueckert, E; Siburian, R; Sklar, P; Smoller, JW; Wray, NR | 1 |
| Austin, MC; Chandran, A; Goswami, DB; Iyo, AH; Jernigan, CS; Karolewicz, B; May, WL; Stockmeier, CA | 1 |
| Buyukdura, JS; Croarkin, PE; Daskalakis, ZJ; Emslie, GJ; Husain, MM; Kennard, BD; Kozel, FA; Melton, T; Nakonezny, PA | 1 |
| Berk, M; Das, P; Dean, OM; Dodd, S; Fritz, K; Malhi, GS; Tanious, M | 1 |
| Geng, L; Pu, M; Reynolds, GP; Shi, Y; Xu, Z; Yuan, Y; Zhang, X; Zhang, Z | 1 |
| Arolt, V; Erfurth, A; Heindel, W; Michael, N; Ohrmann, P; Pfleiderer, B | 1 |
| Magarinos, AM; McEwen, BS; Reagan, LP | 1 |
| Banerjee, SP; Bhandari, R; Boyd, C; Ivey, J; Mirza, Y; Moore, GJ; Rose, M; Rosenberg, DR; Russell, A; Smith, JM; Tang, J | 1 |
| Bain, EE; Charney, DS; Drevets, WC; Hasler, G; Neumeister, A; Shen, J; Tumonis, T; van der Veen, JW | 1 |
| Banerjee, SP; Bhandari, R; Boyd, C; Easter, PC; Ivey, J; Lynch, M; Macmaster, FP; Mirza, Y; Moore, GJ; Renshaw, P; Rose, M; Rosenberg, DR; Smith, JM; Villafuerte, RA | 1 |
| Akil, H; Bunney, WE; Choudary, PV; Evans, SJ; Jones, EG; Li, JZ; Molnar, M; Myers, RM; Tomita, H; Vawter, MP; Watson, SJ | 1 |
| Huuhka, M; Keränen, T; Leinonen, E; Oja, SS; Palmio, J; Peltola, J; Saransaari, P; Suhonen, J | 1 |
| Kugaya, A; Sanacora, G | 1 |
| Anghelescu, I; Bajbouj, M; Brakemeier, EL; Colla, M; Danker-Hopfe, H; Luborzewski, A; Schlattmann, P; Schubert, F; Seifert, F | 1 |
| Coyle, JT; Frye, MA; Huggins, T; Post, RM; Tsai, GE | 1 |
| Chang, K; Howe, M; Saxena, K; Simeonova, D; Steiner, H | 1 |
| Ankerst, DP; Yildiz-Yesiloglu, A | 1 |
| Coric, V; Fenton, LR; Kendell, SF; Krystal, JH; Levin, Y; Sanacora, G; Simen, AA | 1 |
| Ajilore, O; Binesh, N; Darwin, C; Haroon, E; Kumar, A; Kumaran, S; Miller, J; Mintz, J; Thomas, MA | 1 |
| Drevets, WC; Hasler, G; Meyers, N; Shen, J; Tumonis, T; van der Veen, JW | 1 |
| Krystal, JH; Pittenger, C; Sanacora, G | 1 |
| Bennett, MR | 1 |
| Hashimoto, K; Iyo, M; Sawa, A | 1 |
| Brandwein, C; Chourbaji, S; Frasca, A; Fumagalli, F; Gass, P; Hörtnagl, H; Riva, MA; Sohr, R; Sprengel, R; Vogt, MA | 1 |
| Auer, DP; Holsboer, F; Kraft, E; Lipinski, B; Pütz, B; Schill, J | 1 |
| Anand, A; Berman, RM; Cappiello, A; Charney, DS; Heninger, GR; Krystal, JH; Oren, DA | 1 |
| Sapolsky, RM | 1 |
| Rajkowska, G | 1 |
57 review(s) available for glutamic acid and Depression, Involutional
| Article | Year |
|---|---|
Mental depression: Relation to different disease status, newer treatments and its association with COVID-19 pandemic (Review).
Topics: Antidepressive Agents; COVID-19; Cytokine Release Syndrome; Depressive Disorder, Major; Glutamic Acid; Humans; Oxidative Stress | 2021 |
Targeting neuroinflammation by polyphenols: A promising therapeutic approach against inflammation-associated depression.
Topics: Animals; Cytokines; Depressive Disorder, Major; Glutamic Acid; Hypothalamo-Hypophyseal System; Inflammation Mediators; Mice; Neurogenesis; Neuroinflammatory Diseases; Neuronal Plasticity; Polyphenols; Rats; Transcription Factors | 2022 |
Transdiagnostic role of glutamate and white matter damage in neuropsychiatric disorders: A Systematic Review.
Topics: Anisotropy; Bipolar Disorder; Brain; Depressive Disorder, Major; Diffusion Tensor Imaging; Glutamic Acid; Humans; White Matter | 2022 |
Repetitive Transcranial Magnetic Stimulation-Associated Changes in Neocortical Metabolites in Major Depression: A Systematic Review.
Topics: Depression; Depressive Disorder, Major; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Neocortex; Prefrontal Cortex; Transcranial Magnetic Stimulation; Treatment Outcome | 2022 |
Glutamatergic and N-Acetylaspartate Metabolites in Bipolar Disorder: A Systematic Review and Meta-Analysis of Proton Magnetic Resonance Spectroscopy Studies.
Topics: Aspartic Acid; Bipolar Disorder; Depressive Disorder, Major; Glutamic Acid; Glutamine; Humans; Proton Magnetic Resonance Spectroscopy | 2022 |
The roles of neuroinflammation and glutamatergic excitotoxicity in treatment-resistant depression.
Topics: Central Nervous System; Depression; Depressive Disorder, Major; Glutamic Acid; Humans; Neuroinflammatory Diseases | 2023 |
Understanding Lamotrigine's Role in the CNS and Possible Future Evolution.
Topics: Anticonvulsants; Central Nervous System; Depressive Disorder, Major; Epilepsy; Glutamic Acid; Humans; Ion Channels; Lamotrigine; Triazines | 2023 |
Brain metabolic derangements examined using
Topics: Animals; Aspartic Acid; Brain; Depression; Depressive Disorder, Major; Glutamic Acid; Glutamine; Proton Magnetic Resonance Spectroscopy; Rodentia | 2023 |
Brain-wide changes in excitation-inhibition balance of major depressive disorder: a systematic review of topographic patterns of GABA- and glutamatergic alterations.
Topics: Brain; Depressive Disorder, Major; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Magnetic Resonance Imaging; Prefrontal Cortex | 2023 |
The Importance of α-Klotho in Depression and Cognitive Impairment and Its Connection to Glutamate Neurotransmission-An Up-to-Date Review.
Topics: Cognitive Dysfunction; Depression; Depressive Disorder, Major; Glucuronidase; Glutamic Acid; Humans; Synaptic Transmission | 2023 |
[Ketamine: a neuropsychotropic drug with an innovative mechanism of action].
Topics: Animals; Antidepressive Agents; Depressive Disorder, Major; Glutamic Acid; Ketamine; N-Methylaspartate; Pharmaceutical Preparations; Receptors, AMPA | 2023 |
An Update on Glutamatergic System in Suicidal Depression and on the Role of Esketamine.
Topics: Administration, Intranasal; Antidepressive Agents; Clinical Trials as Topic; Databases, Factual; Depression; Depressive Disorder, Major; Drug Compounding; Glutamic Acid; Humans; Ketamine; Receptors, N-Methyl-D-Aspartate; Suicide Prevention; Synaptic Transmission; Time Factors; Treatment Outcome; United States; United States Food and Drug Administration | 2020 |
Astrocyte control of glutamatergic activity: Downstream effects on serotonergic function and emotional behavior.
Topics: Animals; Astrocytes; Depressive Disorder, Major; Emotions; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Glutamic Acid; Humans; Prefrontal Cortex; Selective Serotonin Reuptake Inhibitors; Serotonergic Neurons; Suicide | 2020 |
Overlap in the neural circuitry and molecular mechanisms underlying ketamine abuse and its use as an antidepressant.
Topics: Antidepressive Agents; Brain; Cholinergic Neurons; Depressive Disorder, Major; Depressive Disorder, Treatment-Resistant; Excitatory Amino Acid Antagonists; GABA Agents; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Ketamine; Neural Pathways; Norepinephrine; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Serotonin; Substance-Related Disorders | 2020 |
Immunological Disturbances and Neuroimaging Findings in Major Depressive Disorder (MDD) and Alcohol Use Disorder (AUD) Comorbid Patients.
Topics: Alcoholism; Anxiety Disorders; Brain; Comorbidity; Cytokines; Depressive Disorder, Major; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Inositol; Magnetic Resonance Imaging; Neuroimaging; Neuropsychological Tests; Neurotransmitter Agents; Severity of Illness Index | 2020 |
Clinical overview of NMDA-R antagonists and clinical practice.
Topics: Antidepressive Agents; Depressive Disorder, Major; Glutamic Acid; Humans; Ketamine; Practice Patterns, Physicians'; Receptors, N-Methyl-D-Aspartate | 2020 |
New agents and perspectives in the pharmacological treatment of major depressive disorder.
Topics: Antidepressive Agents; Cholinergic Agents; Depressive Disorder, Major; GABA Agents; Glutamic Acid; Hallucinogens; Humans; Opiate Alkaloids | 2021 |
[Role of astrocytic connexins in the regulation of extracellular glutamate levels: implication for the treatment of major depressive episodes].
Topics: Antidepressive Agents; Astrocytes; Connexins; Depressive Disorder, Major; Glutamic Acid; Humans; Hypothalamo-Hypophyseal System; Pituitary-Adrenal System; Synapses; Synaptic Transmission | 2020 |
Occipital gamma-aminobutyric acid and glutamate-glutamine alterations in major depressive disorder: An mrs study and meta-analysis.
Topics: Depressive Disorder, Major; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Imaging | 2021 |
Novel Glutamatergic Modulators for the Treatment of Mood Disorders: Current Status.
Topics: Animals; Antidepressive Agents; Bipolar Disorder; Depressive Disorder, Major; Excitatory Amino Acid Agents; Glutamic Acid; Humans; Mood Disorders; Receptors, Glutamate | 2021 |
The Translational Potential of Non-coding RNAs and Multimodal MRI Data Sets as Diagnostic and Differential Diagnostic Biomarkers for Mood Disorders.
Topics: Biomarkers; Bipolar Disorder; Brain; Depressive Disorder, Major; Gene Expression Regulation; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; MicroRNAs; Mood Disorders; RNA, Untranslated | 2021 |
Resilience Dysregulation in Major Depressive Disorder: Focus on Glutamatergic Imbalance and Microglial Activation.
Topics: Animals; Brain; Depressive Disorder, Major; Glutamic Acid; Humans; Microglia; Receptors, Glucagon; Resilience, Psychological; Stress, Psychological | 2018 |
Can we increase the speed and efficacy of antidepressant treatments? Part II. Glutamatergic and RNA interference strategies.
Topics: Animals; Antidepressive Agents; Depressive Disorder, Major; Excitatory Amino Acid Agents; Glutamic Acid; Humans; MicroRNAs; RNA Interference | 2018 |
Poor evidence for putative abnormalities in cerebrospinal fluid neurotransmitters in patients with depression versus healthy non-psychiatric individuals: A systematic review and meta-analyses of 23 studies.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Depressive Disorder, Major; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Hydroxyindoleacetic Acid; Male; Methoxyhydroxyphenylglycol; Middle Aged; Neurotransmitter Agents; Young Adult | 2018 |
Differences in excitatory and inhibitory neurotransmitter levels between depressed patients and healthy controls: A systematic review and meta-analysis.
Topics: Depressive Disorder, Major; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Gyrus Cinguli; Humans; Magnetic Resonance Spectroscopy; Prefrontal Cortex | 2018 |
Glutamatergic neurometabolite levels in major depressive disorder: a systematic review and meta-analysis of proton magnetic resonance spectroscopy studies.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Depression; Depressive Disorder, Major; Female; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Proton Magnetic Resonance Spectroscopy; Synaptic Transmission | 2019 |
Novel Pathways in the Treatment of Major Depression: Focus on the Glutamatergic System.
Topics: Depression; Depressive Disorder, Major; Excitatory Amino Acid Agents; Glutamic Acid; Humans; Ketamine; Synaptic Transmission | 2019 |
Neurobiology of rapid-acting antidepressants: convergent effects on GluA1-synaptic function.
Topics: Animals; Antidepressive Agents; Depression; Depressive Disorder, Major; Glutamic Acid; Humans; Ketamine; Neurobiology; Neurogenesis; Neurons; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Synapses; Synaptic Transmission | 2019 |
Glutamate and its receptors in the pathophysiology and treatment of major depressive disorder.
Topics: Animals; Antidepressive Agents; Biomarkers, Pharmacological; Depressive Disorder, Major; Excitatory Amino Acid Agents; Glutamic Acid; Humans; Ketamine; Receptors, Glutamate | 2014 |
Could glutamate spectroscopy differentiate bipolar depression from unipolar?
Topics: Adult; Bipolar Disorder; Depressive Disorder, Major; Diagnosis, Differential; Female; Glutamic Acid; Glutamine; Gyrus Cinguli; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Predictive Value of Tests; Sensitivity and Specificity | 2014 |
Ketamine and rapid-acting antidepressants: a window into a new neurobiology for mood disorder therapeutics.
Topics: Antidepressive Agents; Brain; Depressive Disorder, Major; Depressive Disorder, Treatment-Resistant; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Ketamine; Mood Disorders; Neuronal Plasticity; Prefrontal Cortex | 2015 |
Ketamine and other potential glutamate antidepressants.
Topics: Animals; Antidepressive Agents; Depressive Disorder, Major; Glutamic Acid; Humans; Ketamine; Memantine; Receptors, AMPA; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Treatment Outcome | 2015 |
A brief history of the development of antidepressant drugs: from monoamines to glutamate.
Topics: Antidepressive Agents; Biogenic Monoamines; Depressive Disorder, Major; Glutamic Acid; Humans | 2015 |
Altered γ-aminobutyric acid neurotransmission in major depressive disorder: a critical review of the supporting evidence and the influence of serotonergic antidepressants.
Topics: Animals; Antidepressive Agents; Brain; Depressive Disorder, Major; Evidence-Based Medicine; Fluoxetine; GABA Agents; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Neural Inhibition; Piperazines; Selective Serotonin Reuptake Inhibitors; Serotonin; Sulfides; Synaptic Transmission; Vortioxetine | 2015 |
Role of calcium, glutamate and NMDA in major depression and therapeutic application.
Topics: Animals; Antidepressive Agents; Calcium; Depressive Disorder, Major; Glutamic Acid; Humans; N-Methylaspartate; Neurogenesis; Neuronal Plasticity; Neurotransmitter Agents | 2016 |
Two cellular hypotheses explaining the initiation of ketamine's antidepressant actions: Direct inhibition and disinhibition.
Topics: Animals; Antidepressive Agents; Brain; Depressive Disorder, Major; Depressive Disorder, Treatment-Resistant; Electroconvulsive Therapy; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Interneurons; Ketamine; Models, Neurological; Neural Inhibition; Neuronal Plasticity; Neurons; Protein Subunits; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate | 2016 |
Zinc in the Glutamatergic Theory of Depression.
Topics: Animals; Antidepressive Agents; Depression; Depressive Disorder, Major; Glutamic Acid; Humans; Receptors, N-Methyl-D-Aspartate; Zinc | 2015 |
Emerging treatment mechanisms for depression: focus on glutamate and synaptic plasticity.
Topics: Animals; Antidepressive Agents; Depression; Depressive Disorder, Major; Excitatory Amino Acid Agents; GABA-A Receptor Agonists; Glutamic Acid; Humans; Ketamine; Muscarinic Antagonists; Neuronal Plasticity; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Scopolamine; Stress, Psychological | 2016 |
Glutamate-Based Drug Discovery for Novel Antidepressants.
Topics: Animals; Antidepressive Agents; Depressive Disorder, Major; Drug Design; Drug Discovery; Glutamic Acid; Humans; Ketamine; Molecular Targeted Therapy; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Time Factors | 2016 |
Glutamate and Gamma-Aminobutyric Acid Systems in the Pathophysiology of Major Depression and Antidepressant Response to Ketamine.
Topics: Animals; Antidepressive Agents; Depressive Disorder, Major; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Ketamine | 2017 |
Targeting glutamate signalling in depression: progress and prospects.
Topics: Animals; Antidepressive Agents; Depressive Disorder, Major; Drug Design; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Ketamine; Receptors, N-Methyl-D-Aspartate; Signal Transduction | 2017 |
["Atypical" antidepressive mechanisms: glutamatergic modulation and neuroplasticity in case of tianeptine].
Topics: Amygdala; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Brain; Depressive Disorder, Major; Gene Expression Regulation; Glutamic Acid; Hippocampus; Humans; Long-Term Potentiation; Neuroglia; Neuronal Plasticity; Nucleus Accumbens; Prefrontal Cortex; Stress, Psychological; Thiazepines | 2008 |
Emerging role of glutamate in the pathophysiology of major depressive disorder.
Topics: Brain; Depressive Disorder, Major; Glutamic Acid; Humans; Ketamine; Memantine; Receptors, AMPA; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate | 2009 |
An update on the role of glutamate in the pathophysiology of depression.
Topics: Animals; Antidepressive Agents; Brain; Brain Mapping; Depressive Disorder, Major; Disease Models, Animal; Glutamic Acid; Humans; Mice; Rats; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Synaptic Transmission | 2010 |
Pharmacologic approaches to treatment resistant depression: a re-examination for the modern era.
Topics: Acetylcholine; Antidepressive Agents; Clinical Trials as Topic; Depressive Disorder, Major; Drug Delivery Systems; Drug Resistance; Glutamic Acid; Humans; Melatonin; Selective Serotonin Reuptake Inhibitors; Treatment Outcome | 2010 |
The role of glutamate on the action of antidepressants.
Topics: Antidepressive Agents; Depressive Disorder, Major; Glutamic Acid; Humans; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate | 2011 |
Region and state specific glutamate downregulation in major depressive disorder: a meta-analysis of (1)H-MRS findings.
Topics: Brain; Depressive Disorder, Major; Down-Regulation; Electrons; Glutamic Acid; Humans; Magnetic Resonance Spectroscopy; Models, Biological; Radionuclide Imaging | 2012 |
Bridging the gap between the immune and glutamate hypotheses of schizophrenia and major depression: Potential role of glial NMDA receptor modulators and impaired blood-brain barrier integrity.
Topics: Blood-Brain Barrier; Depressive Disorder, Major; Glutamic Acid; Humans; Inflammation; Kynurenine; Neuroglia; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Synaptic Transmission | 2012 |
Neuroimaging markers of cellular function in major depressive disorder: implications for therapeutics, personalized medicine, and prevention.
Topics: Brain; Depressive Disorder, Major; Drug Discovery; Glutamic Acid; Humans; Models, Neurological; Monoamine Oxidase; Neuroimaging; Precision Medicine; Radionuclide Imaging; Receptors, Dopamine; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors; Serotonin Plasma Membrane Transport Proteins | 2012 |
Pharmacogenetics of antidepressive drugs: a way towards personalized treatment of major depressive disorder.
Topics: Antidepressive Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain-Derived Neurotrophic Factor; CLOCK Proteins; Cytochrome P-450 Enzyme System; Depressive Disorder, Major; Glutamic Acid; Humans; Hypothalamo-Hypophyseal System; Peptidyl-Dipeptidase A; Pituitary-Adrenal System; Polymorphism, Genetic; Precision Medicine; Receptors, Adrenergic; Receptors, Dopamine; Receptors, Serotonin; Signal Transduction; Vesicular Monoamine Transport Proteins | 2012 |
Targeting the glutamatergic system to treat major depressive disorder: rationale and progress to date.
Topics: Antidepressive Agents; Depressive Disorder, Major; Glutamic Acid; Humans; Ketamine; Molecular Targeted Therapy; Randomized Controlled Trials as Topic; Receptors, N-Methyl-D-Aspartate; Treatment Outcome | 2012 |
Multi-locus genome-wide association analysis supports the role of glutamatergic synaptic transmission in the etiology of major depressive disorder.
Topics: Depressive Disorder, Major; Genetic Predisposition to Disease; Genome-Wide Association Study; Glutamic Acid; Humans; Synaptic Transmission | 2012 |
Structural plasticity and tianeptine: cellular and molecular targets.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Antidepressive Agents, Tricyclic; Apoptosis; Atrophy; Dentate Gyrus; Depressive Disorder, Major; Glutamic Acid; Hippocampus; Humans; N-Methylaspartate; Neuronal Plasticity; Neurons; Serotonin; Thiazepines | 2002 |
Beyond monoamines: glutamatergic function in mood disorders.
Topics: Bipolar Disorder; Brain; Clinical Trials as Topic; Depressive Disorder, Major; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Lamotrigine; Magnetic Resonance Spectroscopy; Neuroglia; Receptors, Glutamate; Riluzole; Treatment Outcome; Triazines | 2005 |
Review of 1H magnetic resonance spectroscopy findings in major depressive disorder: a meta-analysis.
Topics: Aspartic Acid; Brain; Choline; Creatine; Depressive Disorder, Major; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Inositol; Magnetic Resonance Spectroscopy; Phosphocreatine; Protons | 2006 |
The NMDA receptor as a therapeutic target in major depressive disorder.
Topics: Animals; Antidepressive Agents; Clinical Trials as Topic; Depressive Disorder, Major; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Receptors, N-Methyl-D-Aspartate | 2007 |
Histopathology of the prefrontal cortex in major depression: what does it tell us about dysfunctional monoaminergic circuits?
Topics: Animals; Axons; Cell Count; Cell Size; Cognition; Depressive Disorder, Major; Dopamine; Emotions; Female; Glutamic Acid; Haplorhini; Humans; Locus Coeruleus; Male; Motivation; Nerve Growth Factors; Nerve Tissue Proteins; Neural Pathways; Neuroglia; Neurons; Norepinephrine; Prefrontal Cortex; Raphe Nuclei; Receptors, Adrenergic; Receptors, Dopamine; Receptors, Glutamate; Receptors, Serotonin; Reward; Serotonin; Tryptophan Hydroxylase; Tyrosine 3-Monooxygenase | 2000 |
15 trial(s) available for glutamic acid and Depression, Involutional
| Article | Year |
|---|---|
Assessment of Relationship of Ketamine Dose With Magnetic Resonance Spectroscopy of Glx and GABA Responses in Adults With Major Depression: A Randomized Clinical Trial.
Topics: Adult; Antidepressive Agents; Depressive Disorder, Major; Female; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Ketamine; Magnetic Resonance Imaging; Male; Middle Aged; Prefrontal Cortex | 2020 |
Clinical Trial of the Potassium Channel Activator Diazoxide for Major Depressive Disorder Halted Due to Intolerability.
Topics: Adult; Aged; Cross-Over Studies; Depressive Disorder, Major; Depressive Disorder, Treatment-Resistant; Diazoxide; Dose-Response Relationship, Drug; Double-Blind Method; Early Termination of Clinical Trials; Female; Glutamic Acid; Humans; Male; Middle Aged; Potassium Channels; Psychiatric Status Rating Scales; Treatment Outcome | 2018 |
Glutamatergic Signaling Drives Ketamine-Mediated Response in Depression: Evidence from Dynamic Causal Modeling.
Topics: Adolescent; Adult; Affect; Aged; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Antidepressive Agents; Brain; Cross-Over Studies; Depressive Disorder, Major; Double-Blind Method; Evoked Potentials, Somatosensory; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Humans; Infusions, Intravenous; Ketamine; Magnetoencephalography; Male; Middle Aged; Models, Neurological; N-Methylaspartate; Time Factors; Treatment Outcome; Young Adult | 2018 |
7T
Topics: Adult; Antidepressive Agents; Brain; Cross-Over Studies; Depressive Disorder, Major; Depressive Disorder, Treatment-Resistant; Double-Blind Method; Female; Glutamic Acid; Glutamine; Humans; Ketamine; Male; Proton Magnetic Resonance Spectroscopy | 2018 |
Anterior cingulate cortex and cerebellar hemisphere neurometabolite changes in depression treatment: A 1H magnetic resonance spectroscopy study.
Topics: Adolescent; Adult; Antidepressive Agents; Aspartic Acid; Cerebellum; Choline; Depressive Disorder, Major; Female; Glutamic Acid; Glutamine; Gyrus Cinguli; Humans; Inositol; Male; Middle Aged; Prefrontal Cortex; Proton Magnetic Resonance Spectroscopy; Selective Serotonin Reuptake Inhibitors; Treatment Outcome; Young Adult | 2014 |
Glutamatergic system abnormalities in posttraumatic stress disorder.
Topics: Adult; Biomarkers; Case-Control Studies; Depressive Disorder, Major; Double-Blind Method; Female; Follow-Up Studies; Glutamic Acid; Glutamine; Humans; Male; Middle Aged; Stress Disorders, Post-Traumatic | 2015 |
The effects of low-dose ketamine on the prefrontal cortex and amygdala in treatment-resistant depression: A randomized controlled study.
Topics: Adult; Amygdala; Antidepressive Agents; Depressive Disorder, Major; Depressive Disorder, Treatment-Resistant; Dose-Response Relationship, Drug; Double-Blind Method; Excitatory Amino Acid Antagonists; Female; Fluorodeoxyglucose F18; Glutamic Acid; Humans; Ketamine; Linear Models; Male; Middle Aged; Positron-Emission Tomography; Prefrontal Cortex; Psychiatric Status Rating Scales; Radiopharmaceuticals | 2016 |
The Nucleus Accumbens and Ketamine Treatment in Major Depressive Disorder.
Topics: Adult; Case-Control Studies; Cross-Sectional Studies; Depressive Disorder, Major; Female; Functional Laterality; Glutamic Acid; Hippocampus; Humans; Hypertrophy; Ketamine; Longitudinal Studies; Magnetic Resonance Imaging; Male; Nucleus Accumbens; Proton Magnetic Resonance Spectroscopy; Young Adult | 2017 |
The glutamatergic system and its relation to the clinical effect of therapeutic-sleep deprivation in depression - an MR spectroscopy study.
Topics: Adult; Aged; Analysis of Variance; Antidepressive Agents; Choline; Creatine; Depressive Disorder, Major; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Image Interpretation, Computer-Assisted; Magnetic Resonance Spectroscopy; Male; Middle Aged; Occipital Lobe; Parietal Lobe; Prefrontal Cortex; Psychiatric Status Rating Scales; Sex Factors; Sleep Deprivation; Treatment Outcome | 2009 |
Lack of effect of citalopram on magnetic resonance spectroscopy measures of glutamate and glutamine in frontal cortex of healthy volunteers.
Topics: Adult; Citalopram; Depressive Disorder, Major; Female; Frontal Lobe; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Male; Psychiatric Status Rating Scales; Selective Serotonin Reuptake Inhibitors; Software; Young Adult | 2010 |
Glutamate normalization with ECT treatment response in major depression.
Topics: Adult; Aspartic Acid; Case-Control Studies; Choline; Depressive Disorder, Major; Electroconvulsive Therapy; Female; Glutamic Acid; Gyrus Cinguli; Humans; Male | 2013 |
Metabolite profiles in the anterior cingulate cortex of depressed patients differentiate those taking N-acetyl-cysteine versus placebo.
Topics: Acetylcysteine; Aspartic Acid; Depressive Disorder, Major; Double-Blind Method; Female; Free Radical Scavengers; Functional Neuroimaging; Glutamic Acid; Glutamine; Gyrus Cinguli; Humans; Inositol; Male; Middle Aged; Oxidative Stress | 2013 |
Divalproex sodium reduces overall aggression in youth at high risk for bipolar disorder.
Topics: Adolescent; Affect; Aggression; Antimanic Agents; Attention Deficit and Disruptive Behavior Disorders; Attention Deficit Disorder with Hyperactivity; Bipolar Disorder; Child; Cyclothymic Disorder; Depressive Disorder, Major; Dysthymic Disorder; Female; GABA Agents; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Male; Risk Factors; Valproic Acid | 2006 |
Preliminary evidence of riluzole efficacy in antidepressant-treated patients with residual depressive symptoms.
Topics: Adult; Antidepressive Agents; Depressive Disorder, Major; Drug Resistance; Drug Therapy, Combination; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Humans; Linear Models; Male; Middle Aged; Riluzole; Treatment Outcome | 2007 |
Antidepressant effects of ketamine in depressed patients.
Topics: Adult; Antidepressive Agents; Depressive Disorder, Major; Dose-Response Relationship, Drug; Double-Blind Method; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Humans; Injections, Intravenous; Ketamine; Male; Middle Aged; Psychiatric Status Rating Scales; Receptors, N-Methyl-D-Aspartate; Severity of Illness Index | 2000 |
104 other study(ies) available for glutamic acid and Depression, Involutional
| Article | Year |
|---|---|
Prospective Investigation of Glutamate Levels and Percentage Gray Matter in the Medial Prefrontal Cortex in Females at Risk for Postpartum Depression.
Topics: Depression, Postpartum; Depressive Disorder, Major; Female; Glutamic Acid; Gray Matter; Hormones; Humans; Prefrontal Cortex; Pregnancy; Prospective Studies | 2022 |
Disturbance of neurotransmitter metabolism in drug-naïve, first-episode major depressive disorder: a comparative study on adult and adolescent cohorts.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adolescent; Adult; Biomarkers; Depressive Disorder, Major; Dopamine; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; Methoxyhydroxyphenylglycol; Neurotransmitter Agents; Norepinephrine; Serotonin; Tryptophan; Vanilmandelic Acid | 2022 |
Antidepressant chronotherapeutics normalizes prefrontal
Topics: Antidepressive Agents; Bipolar Disorder; Depressive Disorder, Major; Drug Chronotherapy; Glutamic Acid; Glutamine; Humans; Prefrontal Cortex; Proton Magnetic Resonance Spectroscopy | 2022 |
Predicting Antidepressant Effects of Ketamine: the Role of the Pregenual Anterior Cingulate Cortex as a Multimodal Neuroimaging Biomarker.
Topics: Antidepressive Agents; Biomarkers; Depressive Disorder, Major; Glutamic Acid; Gyrus Cinguli; Humans; Ketamine; Magnetic Resonance Imaging | 2022 |
Regional metabolic heterogeneity in anterior cingulate cortex in major depressive disorder: A multi-voxel
Topics: Aspartic Acid; Depressive Disorder, Major; Glutamic Acid; Glutamine; Gyrus Cinguli; Humans; Inositol; Magnetic Resonance Spectroscopy; Proton Magnetic Resonance Spectroscopy; Young Adult | 2022 |
Evaluation of Prefrontal γ-Aminobutyric Acid and Glutamate Levels in Individuals With Major Depressive Disorder Using Proton Magnetic Resonance Spectroscopy.
Topics: Adult; Cross-Sectional Studies; Depressive Disorder, Major; Female; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Male; Proton Magnetic Resonance Spectroscopy | 2022 |
The association of glutamate level in pregenual anterior cingulate, anhedonia, and emotion-behavior decoupling in patients with major depressive disorder.
Topics: Anhedonia; Depressive Disorder, Major; Emotions; Glutamic Acid; Gyrus Cinguli; Humans | 2022 |
The Utility of Amino Acid Metabolites in the Diagnosis of Major Depressive Disorder and Correlations with Depression Severity.
Topics: Amino Acids; Aspartic Acid; Biomarkers; Depression; Depressive Disorder, Major; Glutamic Acid; Glycine; Humans; Phenylalanine | 2023 |
GluCEST Imaging and Structural Alterations of the Bilateral Hippocampus in First-Episode and Early-Onset Major Depression Disorder.
Topics: Cross-Sectional Studies; Depression; Depressive Disorder, Major; Female; Glutamic Acid; Hippocampus; Humans; Magnetic Resonance Imaging; Male | 2023 |
Glutamate shall not pass: a mechanistic role for astrocytic O-GlcNAc transferase in stress and depression.
Topics: Acetylglucosamine; Animals; Astrocytes; Depression; Depressive Disorder, Major; Glucose; Glutamic Acid; Mice; N-Acetylglucosaminyltransferases; Protein Processing, Post-Translational | 2023 |
Intrahippocampal injection of a selective blocker of NMDA receptors containing the GluN2B subunit, Ro25-6981, increases glutamate neurotransmission and induces antidepressant-like effects.
Topics: Animals; Antidepressive Agents; Depressive Disorder, Major; Excitatory Amino Acid Antagonists; Fluoxetine; Glutamic Acid; Humans; Mice; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2023 |
Effects of Psychotherapy on Glutamatergic Neurotransmission.
Topics: Depressive Disorder, Major; Glutamic Acid; Glutamine; Gyrus Cinguli; Humans; Psychotherapy, Psychodynamic; Synaptic Transmission | 2023 |
Glutamatergic and GABA-ergic abnormalities in First-episode depression. A 1-year follow-up 1H-MR spectroscopic study.
Topics: Depression; Depressive Disorder, Major; Follow-Up Studies; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Prefrontal Cortex; Proton Magnetic Resonance Spectroscopy | 2020 |
Altered neurometabolism in major depressive disorder: A whole brain
Topics: Adult; Aspartic Acid; Brain; Choline; Creatine; Depressive Disorder, Major; Energy Metabolism; Female; Glutamic Acid; Glutamine; Humans; Male; Middle Aged; Proton Magnetic Resonance Spectroscopy; Young Adult | 2020 |
Topics: Adult; Depression; Depressive Disorder, Major; gamma-Aminobutyric Acid; Glutamic Acid; Gyrus Cinguli; Humans; Proton Magnetic Resonance Spectroscopy; Sleep; Sleep Initiation and Maintenance Disorders | 2020 |
Neurotransmitters and Neurometabolites in Late-Life Depression: A Preliminary Magnetic Resonance Spectroscopy Study at 7T.
Topics: Aspartic Acid; Creatine; Depression; Depressive Disorder, Major; Glutamic Acid; Gyrus Cinguli; Humans; Infant; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Neurotransmitter Agents; Proton Magnetic Resonance Spectroscopy | 2021 |
Association Between Anterior Cingulate Cortex Neurochemical Profile and Clinical Remission After Electroconvulsive Treatment in Major Depressive Disorder: A Longitudinal 1H Magnetic Resonance Spectroscopy Study.
Topics: Adult; Depressive Disorder, Major; Electroconvulsive Therapy; Female; Glutamic Acid; Gyrus Cinguli; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged | 2021 |
Reduced adaptation of glutamatergic stress response is associated with pessimistic expectations in depression.
Topics: Adaptation, Physiological; Adolescent; Adult; Anhedonia; Case-Control Studies; Depressive Disorder, Major; Female; Follow-Up Studies; Glutamic Acid; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Pessimism; Prefrontal Cortex; Stress, Physiological; Stress, Psychological; Young Adult | 2021 |
Ketamine decreases neuronally released glutamate via retrograde stimulation of presynaptic adenosine A1 receptors.
Topics: Animals; Antidepressive Agents; Depressive Disorder, Major; Glutamic Acid; Humans; Ketamine; Receptor, Adenosine A1; Receptors, N-Methyl-D-Aspartate | 2021 |
The recency ratio is associated with reduced CSF glutamate in late-life depression.
Topics: Aged; Brain; Cognition; Cross-Sectional Studies; Depressive Disorder, Major; Female; Glutamic Acid; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neuropsychological Tests | 2017 |
Delineation of molecular pathway activities of the chronic antidepressant treatment response suggests important roles for glutamatergic and ubiquitin-proteasome systems.
Topics: Animals; Antidepressive Agents; Depressive Disorder, Major; Glutamic Acid; Hippocampus; Humans; Leukocytes, Mononuclear; Male; Metabolomics; Mice; Mice, Inbred DBA; Nitric Oxide Synthase Type I; Paroxetine; Proteasome Endopeptidase Complex; Proteomics; Receptors, N-Methyl-D-Aspartate; Swimming; Ubiquitin | 2017 |
Ketamine-induced reduction in mGluR5 availability is associated with an antidepressant response: an [
Topics: Adult; Antidepressive Agents; Brain; Carbon Radioisotopes; Case-Control Studies; Depression; Depressive Disorder, Major; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Humans; Ketamine; Male; Positron-Emission Tomography; Receptor, Metabotropic Glutamate 5 | 2018 |
Involvement of the glutamate/glutamine cycle and glutamate transporter GLT-1 in antidepressant-like effects of Xiao Yao san on chronically stressed mice.
Topics: Animals; Antidepressive Agents; China; Depressive Disorder, Major; Drugs, Chinese Herbal; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Glutamic Acid; Glutamine; Humans; Male; Mice | 2017 |
Neuroprogression and Immune Activation in Major Depressive Disorder.
Topics: Apoptosis; Brain; Depressive Disorder, Major; Female; Glutamic Acid; Humans; Male; Microglia; Oxidative Stress; Perimenopause | 2017 |
Anterior cingulate cortex γ-aminobutyric acid deficits in youth with depression.
Topics: Adolescent; Anhedonia; Brain; Child; Depression; Depressive Disorder, Major; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Gyrus Cinguli; Humans; Male; Proton Magnetic Resonance Spectroscopy; Severity of Illness Index; Young Adult | 2017 |
Brain glutamate in medication-free depressed patients: a proton MRS study at 7 Tesla.
Topics: Adolescent; Adult; Depressive Disorder, Major; Female; Glutamic Acid; Glutamine; Gyrus Cinguli; Humans; Male; Middle Aged; Occipital Lobe; Proton Magnetic Resonance Spectroscopy; Putamen; Young Adult | 2018 |
Hippocampal metabolic differences implicate distinctions between physical and psychological stress in four rat models of depression.
Topics: Animals; Behavior, Animal; Depression; Depressive Disorder, Major; Disease Models, Animal; Gas Chromatography-Mass Spectrometry; Glutamic Acid; Helplessness, Learned; Hippocampus; Lipid Metabolism; Male; Rats; Rats, Sprague-Dawley; Stress, Physiological; Stress, Psychological | 2018 |
Glutamatergic hypofunction in medication-free major depression: Secondary effects of affective diagnosis and relationship to peripheral glutaminase.
Topics: Adult; Case-Control Studies; Depressive Disorder, Major; Female; Glutamic Acid; Glutaminase; Glutamine; Gyrus Cinguli; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Young Adult | 2018 |
Myo-inositol, Glutamate, and Glutamine in the Prefrontal Cortex, Hippocampus, and Amygdala in Major Depression.
Topics: Adult; Amygdala; Depressive Disorder, Major; Female; Glutamic Acid; Glutamine; Hippocampus; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Middle Aged; Prefrontal Cortex; Temporal Lobe | 2017 |
Elevated tumor necrosis factor-alpha receptor subtype 1 and the association with abnormal brain function in treatment-resistant depression.
Topics: Adult; Brain; Depressive Disorder, Major; Depressive Disorder, Treatment-Resistant; Female; Glutamic Acid; Gyrus Cinguli; Humans; Male; Middle Aged; Positron-Emission Tomography; Receptors, Tumor Necrosis Factor, Type I | 2018 |
Increased inflammation and brain glutamate define a subtype of depression with decreased regional homogeneity, impaired network integrity, and anhedonia.
Topics: Adult; Anhedonia; Basal Ganglia; Brain Mapping; Depressive Disorder, Major; Female; Glutamic Acid; Humans; Inflammation; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Oxygen; Psychiatric Status Rating Scales; Rest; Reward | 2018 |
Genetic variant in SLC1A2 is associated with elevated anterior cingulate cortex glutamate and lifetime history of rapid cycling.
Topics: Adult; Bipolar Disorder; Cohort Studies; Depressive Disorder, Major; Excitatory Amino Acid Transporter 2; Female; Glutamic Acid; Gyrus Cinguli; Humans; Hyaluronan Receptors; Male; Middle Aged; Polymorphism, Single Nucleotide; Proton Magnetic Resonance Spectroscopy | 2019 |
Rostral Anterior Cingulate Glutamine/Glutamate Disbalance in Major Depressive Disorder Depends on Symptom Severity.
Topics: Adult; Anhedonia; Depressive Disorder, Major; Female; Glutamic Acid; Glutamine; Gyrus Cinguli; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Severity of Illness Index | 2019 |
Association between prefrontal glutamine levels and neuroticism determined using proton magnetic resonance spectroscopy.
Topics: Adult; Anxiety Disorders; Cross-Sectional Studies; Depressive Disorder, Major; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Male; Neuroticism; Prefrontal Cortex; Proton Magnetic Resonance Spectroscopy; Young Adult | 2019 |
Hippocampal abnormalities of glutamate/glutamine, N-acetylaspartate and choline in patients with depression are related to past illness burden.
Topics: Adult; Aspartic Acid; Case-Control Studies; Choline; Cost of Illness; Cross-Sectional Studies; Depressive Disorder, Major; Female; Glutamic Acid; Glutamine; Hippocampus; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged | 2013 |
Loss of Ahi1 impairs neurotransmitter release and causes depressive behaviors in mice.
Topics: Adaptor Proteins, Vesicular Transport; Animals; Behavior, Animal; Depressive Disorder, Major; Dopamine; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Imipramine; Mice; Mice, Knockout; Neurotransmitter Agents; Proto-Oncogene Proteins; Serotonin | 2014 |
Decreased plasma neuroactive amino acids and increased nitric oxide levels in melancholic major depressive disorder.
Topics: Adult; Aged; Amino Acids; Antidepressive Agents; Aspartic Acid; Biomarkers; Depressive Disorder, Major; Female; Follow-Up Studies; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Humans; Male; Middle Aged; Nitric Oxide; Young Adult | 2014 |
Glutamate alterations associated with transcranial magnetic stimulation in youth depression: a case series.
Topics: Adolescent; Depressive Disorder, Major; Female; Glutamic Acid; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Transcranial Magnetic Stimulation; Young Adult | 2014 |
Glutamate metabolism in major depressive disorder.
Topics: Adult; Aged; Carbon Isotopes; Citric Acid Cycle; Depressive Disorder, Major; Female; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Mitochondria; Models, Biological; Neuroimaging; Occipital Lobe; Protons; Young Adult | 2014 |
Neurochemistry of major depression: a study using magnetic resonance spectroscopy.
Topics: Adult; Citalopram; Depressive Disorder, Major; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutathione; Humans; Magnetic Resonance Spectroscopy; Male; Selective Serotonin Reuptake Inhibitors; Treatment Outcome | 2015 |
Defects in dendrite and spine maturation and synaptogenesis associated with an anxious-depressive-like phenotype of GABAA receptor-deficient mice.
Topics: Animals; Anxiety; Brain-Derived Neurotrophic Factor; Cells, Cultured; Cerebral Cortex; Dendrites; Depression; Depressive Disorder, Major; Disease Models, Animal; Female; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Mice, 129 Strain; Neurogenesis; Phenotype; Receptors, GABA-A; Synapses | 2015 |
Decreased occipital cortical glutamate levels in response to successful cognitive-behavioral therapy and pharmacotherapy for major depressive disorder.
Topics: Adult; Antidepressive Agents; Biomarkers; Cognitive Behavioral Therapy; Depressive Disorder, Major; Glutamic Acid; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neurotransmitter Agents; Occipital Lobe; Psychiatric Status Rating Scales; Treatment Outcome; Young Adult | 2014 |
Dissociation of glutamate and cortical thickness is restricted to regions subserving trait but not state markers in major depressive disorder.
Topics: Adult; Biomarkers; Case-Control Studies; Depressive Disorder; Depressive Disorder, Major; Dissociative Disorders; Female; Glutamic Acid; Gyrus Cinguli; Humans; Male; Middle Aged; Neurotransmitter Agents; Organ Size; Young Adult | 2014 |
(13)C magnetic resonance spectroscopy and glutamate metabolism in mood disorders: current challenges, potential opportunities.
Topics: Depressive Disorder, Major; Female; Glutamic Acid; Humans; Magnetic Resonance Spectroscopy; Male; Mitochondria; Neuroimaging; Occipital Lobe | 2014 |
The positive effect on ketamine as a priming adjuvant in antidepressant treatment.
Topics: Animals; Antidepressive Agents; Anxiety; Aspartic Acid; Behavior, Animal; Brain; Depression; Depressive Disorder, Major; Disease Models, Animal; Drug Therapy, Combination; Fluoxetine; Glutamic Acid; Imipramine; Ketamine; Male; Prefrontal Cortex; Pyramidal Cells; Rats; Rats, Wistar; Stress, Psychological | 2015 |
Sex differences in glutamate receptor gene expression in major depression and suicide.
Topics: Adult; Case-Control Studies; Depressive Disorder, Major; Female; Gene Expression; Glutamic Acid; Humans; Ketamine; Male; Prefrontal Cortex; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Sex Factors; Suicide; Transcriptome | 2015 |
Hippocampal glutamate is increased and associated with risky drinking in young adults with major depression.
Topics: Alcohol Drinking; Case-Control Studies; Depressive Disorder, Major; Female; Glutamic Acid; Hippocampus; Humans; Male; Proton Magnetic Resonance Spectroscopy; Risk-Taking; Young Adult | 2015 |
A pilot in vivo proton magnetic resonance spectroscopy study of amino acid neurotransmitter response to ketamine treatment of major depressive disorder.
Topics: Adult; Amino Acids; Antidepressive Agents; Brain; Depressive Disorder, Major; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Ketamine; Magnetic Resonance Imaging; Male; Middle Aged; Neurotransmitter Agents; Pilot Projects; Proton Magnetic Resonance Spectroscopy; Psychiatric Status Rating Scales; Tritium | 2016 |
Incoordination among Subcellular Compartments Is Associated with Depression-Like Behavior Induced by Chronic Mild Stress.
Topics: Animals; Behavior, Animal; Chronic Disease; Depressive Disorder, Major; Dietary Sucrose; Disease Models, Animal; Excitatory Postsynaptic Potentials; Food Preferences; GABAergic Neurons; Glutamic Acid; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Male; Maze Learning; Mice, Transgenic; Motor Activity; Neural Inhibition; Neural Pathways; Prefrontal Cortex; Stress, Psychological; Swimming; Time Factors | 2016 |
A Computational Model of Major Depression: the Role of Glutamate Dysfunction on Cingulo-Frontal Network Dynamics.
Topics: Action Potentials; Brain Waves; Cognition; Computer Simulation; Deep Brain Stimulation; Depressive Disorder, Major; Disease Progression; Emotions; Frontal Lobe; Glutamic Acid; Gyrus Cinguli; Humans; Memory, Short-Term; Models, Neurological; Neural Pathways; Neurons; Selective Serotonin Reuptake Inhibitors; Serotonin | 2017 |
Transcranial magnetic stimulation potentiates glutamatergic neurotransmission in depressed adolescents.
Topics: Adolescent; Brain; Depressive Disorder, Major; Female; Follow-Up Studies; Glutamic Acid; Gyrus Cinguli; Humans; Male; Pilot Projects; Prefrontal Cortex; Prospective Studies; Proton Magnetic Resonance Spectroscopy; Synaptic Transmission; Transcranial Magnetic Stimulation; Treatment Outcome | 2016 |
Conceptual convergence: increased inflammation is associated with increased basal ganglia glutamate in patients with major depression.
Topics: Adult; Basal Ganglia; Brain; C-Reactive Protein; Cross-Sectional Studies; Depression; Depressive Disorder, Major; Female; Glutamic Acid; Gyrus Cinguli; Humans; Inflammation; Interferon-alpha; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged | 2016 |
A pilot integrative genomics study of GABA and glutamate neurotransmitter systems in suicide, suicidal behavior, and major depressive disorder.
Topics: Adult; Depressive Disorder, Major; Female; gamma-Aminobutyric Acid; Gene Expression Regulation; Genomics; Genotype; Glutamic Acid; Humans; Male; Middle Aged; Neurotransmitter Agents; Pilot Projects; Polymorphism, Single Nucleotide; Postmortem Changes; Suicidal Ideation | 2016 |
Elevated prefrontal cortex GABA in patients with major depressive disorder after TMS treatment measured with proton magnetic resonance spectroscopy.
Topics: Adult; Aged; Depressive Disorder, Major; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Prefrontal Cortex; Proton Magnetic Resonance Spectroscopy; Psychiatric Status Rating Scales; Transcranial Magnetic Stimulation; Treatment Outcome; Young Adult | 2016 |
Abnormality in glutamine-glutamate cycle in the cerebrospinal fluid of cognitively intact elderly individuals with major depressive disorder: a 3-year follow-up study.
Topics: Aged; Aging; Chromatography, High Pressure Liquid; Cognition; Depressive Disorder, Major; Female; Follow-Up Studies; Glutamic Acid; Glutamine; Humans; Male; Psychiatric Status Rating Scales; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2016 |
Bidirectional Homeostatic Regulation of a Depression-Related Brain State by Gamma-Aminobutyric Acidergic Deficits and Ketamine Treatment.
Topics: Animals; Behavior, Animal; Depressive Disorder, Major; Down-Regulation; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Homeostasis; Ketamine; Mice; Prefrontal Cortex; Receptors, AMPA; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Synapses | 2016 |
Altered neuronal spontaneous activity correlates with glutamate concentration in medial prefrontal cortex of major depressed females: An fMRI-MRS study.
Topics: Adult; Antidepressive Agents; Depressive Disorder, Major; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Imaging; Neurons; Prefrontal Cortex; Psychiatric Status Rating Scales | 2016 |
What Are We Learning From Early-Phase Clinical Trials With Glutamate Targeting Medications for the Treatment of Major Depressive Disorder.
Topics: Antidepressive Agents; Depressive Disorder, Major; Glutamic Acid; Humans | 2016 |
Prefrontal inositol levels and implicit decision-making in healthy individuals and depressed patients.
Topics: Adult; Aspartic Acid; Decision Making; Delay Discounting; Depressive Disorder, Major; Diagnostic and Statistical Manual of Mental Disorders; Female; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Inositol; Learning; Magnetic Resonance Imaging; Male; Middle Aged; Nervous System Physiological Phenomena; Neuroimaging; Neurons; Neuropsychological Tests; Prefrontal Cortex; Reproducibility of Results; Task Performance and Analysis | 2016 |
MicroRNA 101b Is Downregulated in the Prefrontal Cortex of a Genetic Model of Depression and Targets the Glutamate Transporter SLC1A1 (EAAT3) in Vitro.
Topics: Animals; Behavior, Animal; Depressive Disorder, Major; Disease Models, Animal; Down-Regulation; Excitatory Amino Acid Transporter 3; Gene Expression Profiling; Gene Regulatory Networks; Genetic Predisposition to Disease; Glutamic Acid; Male; MicroRNAs; Oligonucleotide Array Sequence Analysis; Phenotype; Prefrontal Cortex; Rats, Inbred Strains; RNA, Messenger; Signal Transduction | 2016 |
A spectroscopic approach toward depression diagnosis: local metabolism meets functional connectivity.
Topics: Adult; Cerebral Cortex; Connectome; Creatine; Depressive Disorder, Major; Female; Glutamic Acid; Glutamine; Gyrus Cinguli; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged | 2017 |
Systems biology integration of proteomic data in rodent models of depression reveals involvement of the immune response and glutamatergic signaling.
Topics: Animals; Depressive Disorder, Major; Disease Models, Animal; Glutamic Acid; Mice; Proteomics; Rats; Signal Transduction; Systems Biology | 2016 |
Metabolomic signatures of drug response phenotypes for ketamine and esketamine in subjects with refractory major depressive disorder: new mechanistic insights for rapid acting antidepressants.
Topics: Adult; Arginine; Citrulline; Depressive Disorder, Major; Depressive Disorder, Treatment-Resistant; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Humans; Indoleacetic Acids; Infusions, Intravenous; Ketamine; Male; Metabolomics; Methionine; Middle Aged; Ornithine; Phenotype; Phospholipids; Tryptophan; Urea | 2016 |
A pilot study of hippocampal N-acetyl-aspartate in youth with treatment resistant major depression.
Topics: Adolescent; Aspartic Acid; Brain; Case-Control Studies; Depressive Disorder, Major; Depressive Disorder, Treatment-Resistant; Female; Glutamic Acid; Hippocampus; Humans; Magnetic Resonance Imaging; Male; Pilot Projects; Proton Magnetic Resonance Spectroscopy; Young Adult | 2017 |
Proton MR spectroscopy of the hippocampus at 3 T in patients with unipolar major depressive disorder: correlates and predictors of treatment response.
Topics: Adult; Aspartic Acid; Case-Control Studies; Choline; Depressive Disorder, Major; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Hippocampus; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Protons; Statistics, Nonparametric; Young Adult | 2009 |
Amino acid neurotransmitters assessed by proton magnetic resonance spectroscopy: relationship to treatment resistance in major depressive disorder.
Topics: Adult; Brain; Case-Control Studies; Depressive Disorder, Major; Drug Resistance; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Gyrus Cinguli; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neurotransmitter Agents; Occipital Lobe | 2009 |
Hippocampal metabolic abnormalities at first onset and with recurrent episodes of a major depressive disorder: a proton magnetic resonance spectroscopy study.
Topics: Adult; Analysis of Variance; Aspartic Acid; Choline; Depressive Disorder, Major; Female; Glutamic Acid; Glutamine; Hippocampus; Humans; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Organ Size; Protons; Recurrence | 2009 |
The relationship between aberrant neuronal activation in the pregenual anterior cingulate, altered glutamatergic metabolism, and anhedonia in major depression.
Topics: Adult; Arousal; Aspartic Acid; Blood Glucose; Corpus Callosum; Depressive Disorder, Major; Dominance, Cerebral; Emotions; Energy Metabolism; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Gyrus Cinguli; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neurons; Oxygen Consumption; Synaptic Transmission | 2009 |
Global brain gene expression analysis links glutamatergic and GABAergic alterations to suicide and major depression.
Topics: Adult; Animals; Brain; Depressive Disorder, Major; gamma-Aminobutyric Acid; Gene Expression Profiling; Glutamic Acid; Humans; Male; Middle Aged; Oligonucleotide Array Sequence Analysis; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Suicide | 2009 |
Altered expression of glutamate signaling, growth factor, and glia genes in the locus coeruleus of patients with major depression.
Topics: Adolescent; Adult; Aged; Depressive Disorder, Major; Female; Gene Expression Profiling; Gene Expression Regulation; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Humans; Intercellular Signaling Peptides and Proteins; Locus Coeruleus; Male; Microdissection; Middle Aged; Models, Biological; Nerve Tissue Proteins; Neuroglia; Oligonucleotide Array Sequence Analysis; RNA, Messenger; Signal Transduction; Young Adult | 2011 |
Oxidative stress and brain glutamate-mediated excitability in depressed patients.
Topics: Brain; Ceruloplasmin; Copper; Depressive Disorder, Major; Dominance, Cerebral; Evoked Potentials, Somatosensory; Female; Glutamic Acid; Humans; Iron; Magnetoencephalography; Male; Middle Aged; Oxidative Stress; Reference Values; Synaptic Transmission; Transferrin; Zinc | 2010 |
Chronic corticosterone administration down-regulates metabotropic glutamate receptor 5 protein expression in the rat hippocampus.
Topics: Animals; Anti-Inflammatory Agents; Chronic Disease; Corticosterone; Depressive Disorder, Major; Disease Models, Animal; Down-Regulation; Drug Administration Schedule; Glutamic Acid; Hippocampus; Male; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate | 2010 |
Increased ventricular lactate in chronic fatigue syndrome measured by 1H MRS imaging at 3.0 T. II: comparison with major depressive disorder.
Topics: Adult; Cerebral Ventricles; Depressive Disorder, Major; Fatigue Syndrome, Chronic; Female; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Lactic Acid; Magnetic Resonance Spectroscopy; Middle Aged | 2010 |
Elevated cortical glutamate in young people at increased familial risk of depression.
Topics: Adolescent; Cerebral Cortex; Depression; Depressive Disorder; Depressive Disorder, Major; Family; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Male; Occipital Lobe; Risk Factors; Young Adult | 2011 |
Ventromedial prefrontal spectroscopic abnormalities over the course of depression: a comparison among first episode, remitted recurrent and chronic patients.
Topics: Adult; Age of Onset; Aspartic Acid; Choline; Chronic Disease; Depressive Disorder, Major; Disease Progression; Female; Glutamic Acid; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multivariate Analysis; Prefrontal Cortex | 2011 |
Abnormal cingulate and prefrontal cortical neurochemistry in major depression after electroconvulsive therapy.
Topics: Adult; Analysis of Variance; Aspartic Acid; Creatine; Depressive Disorder, Major; Electroconvulsive Therapy; Female; Glutamic Acid; Gyrus Cinguli; Humans; Magnetic Resonance Spectroscopy; Male; Mental Recall; Middle Aged; Neuropsychological Tests; Phosphocreatine; Prefrontal Cortex; Severity of Illness Index; Treatment Outcome; Verbal Learning | 2011 |
The antidepressant effect of ketamine is not associated with changes in occipital amino acid neurotransmitter content as measured by [(1)H]-MRS.
Topics: Adult; Aged; Antidepressive Agents; Blood Pressure; Depressive Disorder, Major; Dissociative Disorders; Female; gamma-Aminobutyric Acid; Glutamic Acid; Heart Rate; Humans; Ketamine; Magnetic Resonance Spectroscopy; Male; Middle Aged; Occipital Lobe; Protons; Psychiatric Status Rating Scales; Psychometrics; Retrospective Studies; Single-Blind Method; Statistics as Topic; Time Factors; Young Adult | 2011 |
Lack of effect of ketamine on cortical glutamate and glutamine in healthy volunteers: a proton magnetic resonance spectroscopy study.
Topics: Adult; Cerebral Cortex; Depressive Disorder, Major; Female; Glutamic Acid; Glutamine; Humans; Ketamine; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Protons; Young Adult | 2012 |
Who is resilient to depression? Multimodal imaging of the hippocampus in preclinical chronic mild stress model may provide clues.
Topics: Animals; Depressive Disorder, Major; Diffusion Tensor Imaging; Dipeptides; Disease Models, Animal; Glutamic Acid; Hippocampus; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Nerve Degeneration; Rats; Stress, Psychological | 2011 |
Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: evidence for an immune-modulated glutamatergic neurotransmission?
Topics: Adult; Aged; Depressive Disorder, Major; Female; Glutamic Acid; Gyrus Cinguli; Humans; Male; Microglia; Middle Aged; Quinolinic Acid; Serotonin; Synaptic Transmission; Tryptophan | 2011 |
An investigation of amino-acid neurotransmitters as potential predictors of clinical improvement to ketamine in depression.
Topics: Adult; Cerebral Cortex; Depressive Disorder, Major; Excitatory Amino Acid Antagonists; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Ketamine; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neurotransmitter Agents; Predictive Value of Tests; Psychiatric Status Rating Scales; Retrospective Studies | 2012 |
Clinical and cerebral volumetric effects of sodium benzoate, a D-amino acid oxidase inhibitor, in a drug-naïve patient with major depression.
Topics: Antifungal Agents; Brain; D-Amino-Acid Oxidase; Depressive Disorder, Major; Drug Monitoring; Female; Glutamic Acid; Humans; Magnetic Resonance Imaging; Organ Size; Sodium Benzoate; Synaptic Transmission; Treatment Outcome | 2012 |
Gene expression of GABA and glutamate pathway markers in the prefrontal cortex of non-suicidal elderly depressed patients.
Topics: Aged; Aged, 80 and over; Bipolar Disorder; Depressive Disorder, Major; Female; gamma-Aminobutyric Acid; Gene Expression; Glutamic Acid; Humans; Male; Prefrontal Cortex; Signal Transduction; Suicidal Ideation | 2012 |
Cerebrospinal fluid levels of glutamate and corticotropin releasing hormone in major depression before and after treatment.
Topics: Adult; Antidepressive Agents; Case-Control Studies; Corticotropin-Releasing Hormone; Cyclohexanols; Depressive Disorder, Major; Female; Glutamic Acid; Glutamine; Humans; Male; Middle Aged; Suicidal Ideation; Treatment Outcome; Venlafaxine Hydrochloride; Young Adult | 2013 |
Early antidepressant efficacy modulation by glutamatergic gene variants in the STAR*D.
Topics: Adult; Antidepressive Agents; Black or African American; Citalopram; Databases, Genetic; Depressive Disorder, Major; Female; Genotype; Glutamic Acid; Humans; Male; Polymorphism, Single Nucleotide; Receptors, Metabotropic Glutamate; Signal Transduction; Time Factors; Treatment Outcome; White People | 2013 |
Glutamate hypothesis of depression and its consequences for antidepressant treatments.
Topics: Animals; Antidepressive Agents; Brain; Depression; Depressive Disorder, Major; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Molecular Targeted Therapy; Nerve Tissue Proteins; Neurons; Receptors, Glutamate; Synaptic Transmission | 2012 |
Gene expression analysis of novel genes in the prefrontal cortex of major depressive disorder subjects.
Topics: Adult; Aged; Alcoholic Intoxication; Brain Chemistry; Cadaver; Data Interpretation, Statistical; Depressive Disorder, Major; Diagnostic and Statistical Manual of Mental Disorders; Female; Gene Expression; Glutamic Acid; Humans; Male; Middle Aged; Polymerase Chain Reaction; Prefrontal Cortex; RNA; Signal Transduction; Smoking; TOR Serine-Threonine Kinases | 2013 |
Evidence for increased glutamatergic cortical facilitation in children and adolescents with major depressive disorder.
Topics: Adolescent; Case-Control Studies; Cerebral Cortex; Child; Cross-Sectional Studies; Depressive Disorder, Major; Electromyography; Evoked Potentials, Motor; Female; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Male; Motor Cortex; Neural Inhibition; Transcranial Magnetic Stimulation | 2013 |
Influence of genetic polymorphisms in the glutamatergic and GABAergic systems and their interactions with environmental stressors on antidepressant response.
Topics: Adolescent; Adult; Antidepressive Agents; Depressive Disorder, Major; Female; gamma-Aminobutyric Acid; Gene-Environment Interaction; Glutamic Acid; Humans; Life Change Events; Logistic Models; Male; Middle Aged; Polymorphism, Single Nucleotide; Promoter Regions, Genetic | 2013 |
Metabolic changes within the left dorsolateral prefrontal cortex occurring with electroconvulsive therapy in patients with treatment resistant unipolar depression.
Topics: Aged; Brain Mapping; Depressive Disorder, Major; Dominance, Cerebral; Electroconvulsive Therapy; Energy Metabolism; Female; Glutamic Acid; Glutamine; Humans; Image Interpretation, Computer-Assisted; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Prefrontal Cortex; Reference Values | 2003 |
Reduced anterior cingulate glutamatergic concentrations in childhood OCD and major depression versus healthy controls.
Topics: Adolescent; Aspartic Acid; Child; Choline; Creatine; Depressive Disorder, Major; Female; Glutamic Acid; Glutamine; Gyrus Cinguli; Humans; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Obsessive-Compulsive Disorder; Personality Assessment; Phosphocreatine; Reference Values; Synaptic Transmission | 2004 |
Normal prefrontal gamma-aminobutyric acid levels in remitted depressed subjects determined by proton magnetic resonance spectroscopy.
Topics: Adult; Antidepressive Agents; Depressive Disorder, Major; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Middle Aged; Prefrontal Cortex; Psychiatric Status Rating Scales | 2005 |
Reduced anterior cingulate glutamate in pediatric major depression: a magnetic resonance spectroscopy study.
Topics: Adolescent; Brain Chemistry; Depressive Disorder, Major; Female; Glutamic Acid; Glutamine; Gyrus Cinguli; Humans; Magnetic Resonance Spectroscopy; Male | 2005 |
Altered cortical glutamatergic and GABAergic signal transmission with glial involvement in depression.
Topics: Bipolar Disorder; Cerebral Cortex; Depressive Disorder, Major; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; gamma-Aminobutyric Acid; Gene Expression Profiling; Glutamate Plasma Membrane Transport Proteins; Glutamate-Ammonia Ligase; Glutamic Acid; Humans; In Situ Hybridization; Neuroglia; Oligonucleotide Array Sequence Analysis; Receptors, GABA-A; Signal Transduction | 2005 |
Changes in plasma amino acids after electroconvulsive therapy of depressed patients.
Topics: Adult; Aged; Aspartic Acid; Depressive Disorder, Major; Electroconvulsive Therapy; Electroencephalography; Electromyography; Female; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Male; Middle Aged; Time Factors; Tryptophan | 2005 |
Metabolic alterations in the dorsolateral prefrontal cortex after treatment with high-frequency repetitive transcranial magnetic stimulation in patients with unipolar major depression.
Topics: Adult; Brain Mapping; Depressive Disorder, Major; Dominance, Cerebral; Female; Glutamic Acid; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Personality Inventory; Prefrontal Cortex; Transcranial Magnetic Stimulation | 2007 |
Low cerebrospinal fluid glutamate and glycine in refractory affective disorder.
Topics: Adult; Anticonvulsants; Antidepressive Agents; Antimanic Agents; Aspartic Acid; Bipolar Disorder; Chromatography, High Pressure Liquid; Depressive Disorder, Major; Drug Resistance; Electroconvulsive Therapy; Female; Glutamic Acid; Glycine; Humans; Male; Middle Aged; N-Methylaspartate; Statistics as Topic | 2007 |
Measurement of brain metabolites in patients with type 2 diabetes and major depression using proton magnetic resonance spectroscopy.
Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain Chemistry; Choline; Creatine; Depressive Disorder, Major; Diabetes Complications; Diabetes Mellitus, Type 2; Female; Glutamic Acid; Glutamine; Humans; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Prefrontal Cortex; Psychiatric Status Rating Scales | 2007 |
Reduced prefrontal glutamate/glutamine and gamma-aminobutyric acid levels in major depression determined using proton magnetic resonance spectroscopy.
Topics: Adult; Ambulatory Care; Cell Count; Cross-Sectional Studies; Depressive Disorder, Major; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neuroglia; Prefrontal Cortex | 2007 |
Synaptic P2X7 receptor regenerative-loop hypothesis for depression.
Topics: Adenosine Triphosphate; Astrocytes; Bipolar Disorder; Brain; Cerebral Cortex; Depressive Disorder, Major; Genetic Predisposition to Disease; Glutamic Acid; Hippocampus; Humans; Infections; Interleukin-1beta; Microglia; Nerve Net; Nerve Regeneration; Polymorphism, Genetic; Receptors, AMPA; Receptors, Purinergic P2; Receptors, Purinergic P2X7; Synapses; Synaptic Transmission; Toll-Like Receptors; Tumor Necrosis Factor-alpha | 2007 |
Increased levels of glutamate in brains from patients with mood disorders.
Topics: Adult; Aged; Amino Acids; Animals; Autopsy; Brain Chemistry; Depressive Disorder, Major; Female; Glutamic Acid; Humans; Male; Mice; Mice, Inbred ICR; Middle Aged; Mood Disorders; Serine | 2007 |
AMPA receptor subunit 1 (GluR-A) knockout mice model the glutamate hypothesis of depression.
Topics: Animals; Depressive Disorder, Major; Disease Models, Animal; Glutamic Acid; Helplessness, Learned; Hippocampus; Male; Mice; Mice, Knockout; Norepinephrine; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Serotonin | 2008 |
Reduced glutamate in the anterior cingulate cortex in depression: an in vivo proton magnetic resonance spectroscopy study.
Topics: Adult; Aged; Aspartic Acid; Choline; Creatine; Depressive Disorder, Major; Female; Frontal Lobe; Glutamic Acid; Glutamine; Gyrus Cinguli; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Myo-Inositol-1-Phosphate Synthase; Severity of Illness Index | 2000 |
The possibility of neurotoxicity in the hippocampus in major depression: a primer on neuron death.
Topics: Calcium; Cell Death; Depressive Disorder, Major; Glucocorticoids; Glutamic Acid; Hippocampus; Humans; Neurons; Receptors, Glutamate; Synapses | 2000 |