glutamic acid and Astrocytoma, Grade IV

glutamic acid has been researched along with Astrocytoma, Grade IV in 67 studies

Research

Studies (67)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	3 (4.48)	18.2507
2000's	7 (10.45)	29.6817
2010's	34 (50.75)	24.3611
2020's	23 (34.33)	2.80

Authors

Authors	Studies
Ergül, M; Taşkıran, AŞ	1
Akkulak, A; Dağdelen, DN; Diniz, G; Kahraman, DS; Oktay, E; Şenoğlu, M; Yalçın, A; Yalcin, GD	1
Gunn, B; Keniry, M; Litif, C; Lopez, A; Schuenzel, E; Udawant, S	1
Fujita, Y; Hashiguchi, M; Kohmura, E; Kohta, M; Maeyama, M; Nagashima, H; Nakai, T; Sasayama, T; Somiya, Y; Tanaka, H; Tanaka, K; Uozumi, Y	1
Inoue, A; Kanemura, Y; Kitazawa, R; Kunieda, T; Kusakabe, K; Nakamura, Y; Nishikawa, M; Ohnishi, T; Ohtsuka, Y; Ozaki, S; Shigekawa, S; Suehiro, S; Tanaka, J; Watanabe, H; Yamashita, D; Yano, H	1
Feyissa, AM; Quiñones-Hinojosa, A; Rosenfeld, SS	1
Yalcin, GD; Yeşilören, E	1
Gu, Z; Guan, Y; Li, Z; Liu, Y; Lyu, Y; Wang, L; Wang, X; Wang, Y; Xiong, J; Zhang, J	1
Ashkan, K; Kumaria, A	1
Jo, S; Kang, H; Kang, J; Kim, B; Kim, HY; Lee, H; Lee, JM; Lee, JS; Park, E; Park, J; Shin, E; Youn, B; Youn, H	1
Goswami, K; Nandakumar, DN; Prasad, C; Ramaswamy, P; Srinivas, D	1
Chang, YE; Deleyrolle, LP; Dyson, KA; Grippin, AJ; Hou, AY; Huang, J; Jin, L; Karachi, A; Lin, Z; Long, Y; Mitchell, DA; Na, M; Rahman, M; Sayour, EJ; Tao, H; Zhang, W	1
Erisnor, G; Khan, A; Lee, KC; Pei, Z; Wang, HY	1
Bagga, P; Detre, JA; Haris, M; Reddy, R; Rich, LJ; Schnall, MD; Wilson, NE	1
Bao, L; Chen, Y; DeBerardinis, RJ; Hatanpaa, KJ; Luo, W; Patel, T; Shi, X; Wang, Y; Zhang, B; Zhou, M	1
Biffoni, M; Buccarelli, M; Ciocca, M; Cirrone, GAP; Dini, V; Grande, S; Guidoni, L; Luciani, AM; Pallini, R; Palma, A; Ricci-Vitiani, L; Rosi, A; Viti, V	1
Cseh, O; Luchman, HA; Pugh, TJ; Restall, IJ; Richards, LM; Weiss, S	1
Chen, C; Hu, X; Moni, MA; Peng, S; Quinn, JMW; Rahman, MH; Rana, HK	1
Geiß, C; Poschet, G; Régnier-Vigouroux, A; Ruf, W; Witzler, C	1
Akkulak, A; Dagdelen, DN; Donmez Yalcin, G	1
Hörnschemeyer, J; Kirschstein, T; Lange, F	1
Banyas, E; Benbenishty, A; Blinder, P; David, S; Goldshmit, Y; Mayo, L; Perelroizen, R; Ruban, A; Shalom, M; Yakovchuk, A	1
Beck, J; Behringer, SP; Follo, M; Garrelfs, N; Goeldner, JM; Hannibal, L; Heiland, DH; Hofmann, UG; Joseph, K; Kueckelhaus, J; Maier, JP; Pfeifer, D; Ravi, VM; Schnell, O; Sun, N; von Ehr, J; Walch, AK; Will, P	1
Belcaid, Z; Brem, H; Choi, J; Ehresman, J; Huq, S; Jackson, C; Jackson, CM; Kim, T; Kim, YH; Lim, M; Mathios, D; Medikonda, R; Pant, A; Patel, K; Pennington, Z; Routkevitch, D; Saleh, L; Shah, PP; Srivastava, S; Tong, L; Tyler, B; Xia, Y	1
Campomenosi, P; Cappelletti, P; Pollegioni, L; Rabattoni, V; Sacchi, S; Tallarita, E	1
Bruzzone, MG; Cantini, G; Cominelli, M; Corbetta, C; Di Ianni, N; Finocchiaro, G; Patanè, M; Pellegatta, S; Pisati, F; Poliani, PL; Pollo, B; Zucca, I	1
Bergner, C; Hörnschemeyer, J; Kirschstein, T; Köhling, R; Krause, BJ; Lange, F; Linnebacher, M; Mullins, CS; Porath, K; Weßlau, K	1
Alessandrini, A; Corsi, L; Mescola, A	1
Katoh, H; Teramoto, K	1
Amos, A; Bost, J; Maroon, J; Zuccoli, G	1
Carrillo, V; Dubisz, E; Gulzar, H; Mahajan, SS; Morgan, D; Yelskaya, Z	1
Hirato, J; Ikota, H; Kurihara, H; Nagaishi, M; Nakazato, Y; Nobusawa, S; Ogawa, A; Okura, N; Yokoo, H	1
Hayashi, Y; Miyashita, K; Nakada, M; Nobusawa, S; Sabit, H; Suzuki, SO; Tanaka, S	1
Deneka-Hannemann, S; Jarosz, B; Rzeski, W; Stoma, F; Trojanowski, T; Turski, WA; Walczak, K; Zgrajka, W	1
Amiridis, S; Ching, J; Kaye, AH; Morokoff, AP; O'Brien, TJ; Stylli, SS	1
Bachoo, RM; Barnett, S; DeBerardinis, RJ; Foong, C; Hatanpaa, KJ; Huang, Z; Kovacs, Z; Maher, EA; Mashimo, T; Mickey, BE; Nannepaga, S; Piccirillo, SG; Pichumani, K; Singh, DK; Sirasanagandla, S; Tu, BP; Vemireddy, V	1
Aida, T; Harada, T; Namekata, K; Shinagawa, R; Takeda, T; Tanaka, K; Yanagisawa, M	1
Ejima, Y; Gini, B; Hosoda, K; Imahori, T; Irino, Y; Kohmura, E; Kyotani, K; Masui, K; Mischel, PS; Mizowaki, T; Nagashima, H; Sasaki, R; Sasayama, T; Satoh, N; Takata, K; Tanaka, K; Yang, H	1
Blough, M; Cai, L; Cairncross, JG; Chaumeil, MM; Eriksson, P; Izquierdo-Garcia, JL; Luchman, HA; Phillips, JJ; Pieper, RO; Radoul, M; Ronen, SM; Viswanath, P; Weiss, S	1
Amiridis, S; Bjorksten, AR; Ching, J; Kaye, AH; Kountouri, N; Luwor, RB; Morokoff, AP; O'Brien, TJ; Paradiso, L; Stylli, SS; Zheng, T	1
Choi, J; Régnier-Vigouroux, A; Savaskan, NE; Stradmann-Bellinghausen, B; Yakubov, E	1
Boillée, S; Hewett, S; Knackstedt, L; Lewerenz, J; Massie, A	1
Cheng, M; Eberhart, CG; Fan, X; Glunde, K; Kahlert, UD; Koch, K; Maciaczyk, J; Marchionni, L; Raabe, EH	1
Ahmed, SU; Barnett, SC; Bjerkvig, R; Chalmers, AJ; Fack, F; Gottlieb, E; Hock, AK; Keunen, O; Lindsay, SL; Lund-Johansen, M; Miletic, H; Mørkve, SH; Niclou, SP; Oudin, A; Ruppin, E; Sakariassen, PØ; Tardito, S; Wagner, A; Weinstock, A; Zheng, L	1
Bacher-Stier, C; Berndt, M; Bullich, S; Chin, FT; Dinkelborg, LM; Fels, LM; Friebe, M; Gambhir, SS; Gekeler, V; Hoehne, A; Iagaru, AH; Keu, KV; Koglin, N; Kumar, M; Mittra, ES; Moon, DH; Mosci, C; Mueller, A; Schmitt-Willich, H; Stephens, AW	1
Bulik, M; Jancalek, R; Kazda, T; Lakomy, R; Pospisil, P; Slampa, P; Smrcka, M	1
Carro, MS; Heiland, DH; Lange, T; Mader, I; Pfeifer, D; Schlosser, P; Schwarzwald, R; Urbach, H; Vasilikos, I; Weyerbrock, A	1
Ceccanti, M; Chassidim, Y; Colonnese, C; D'Elia, A; Fassler, M; Friedman, A; Inghilleri, M; Nucciarelli, V; Onesti, E; Pell, GS; Prager, O; Raccah, R; Roth, Y; Salvati, M; Santoro, A; Shahar, H; Vazana, U; Veksler, R; Zangen, A	1
Maus, A; Peters, GJ	1
Koster, J; Lasky, JL; Lin, HJ; Panosyan, EH	1
Bjerkvig, R; Enger, PØ; Hajek, M; Jirak, D; Sykova, E; Thorsen, F; van der Kogel, A; Wang, J	1
Aronica, E; Bosma, I; Broekhuizen, AJ; Cloos, J; Heimans, JJ; Kaspers, GJ; Postma, TJ; Tannous, BA; van der Valk, P; van Vuurden, DG; Würdinger, T; Yazdani, M	1
da Rocha, AB; de Araújo, DR; Fedrigo, CA; Grivicich, I; Jotz, GP; Leal, LF; Regner, A; Schunemann, DP; Simon, D	1
Ackermann, H; Blasel, S; Franz, K; Hattingen, E; Weidauer, S; Zanella, F	1
Eloqayli, H; Haukvik, A; Melø, TM; Sonnewald, U	1
Bachoo, RM; Cho, SK; Choi, C; Deberardinis, RJ; Good, LB; Hatanpaa, KJ; Jindal, A; Kapur, P; Maher, EA; Malloy, CR; Marin-Valencia, I; Mashimo, T; Mickey, B; Pascual, JM; Raisanen, J; Rakheja, D; Sun, X; Takahashi, M; Togao, O; Vemireddy, V	1
Bachoo, RM; Baek, H; Cai, L; Cho, S; Deberardinis, RJ; Good, L; Hatanpaa, KJ; Maddie, M; Maher, EA; Malloy, CR; Marin-Valencia, I; Mashimo, T; Matés, JM; Mickey, BE; Pascual, JM; Rajagopalan, KN; Tu, BP; Vemireddy, V; Yang, C; Yang, XL; Zhao, Z	1
Bode, J; Caballero, B; Gaitner, M; Gavish, M; Kietz, S; Kugler, W; Lakomek, M; Peʼer, Y; Veenman, L; Zeno, S	1
Bjorksten, A; D'Abaco, G; Drummond, KJ; Finch, S; Kaye, AH; Morokoff, AP; O'Brien, TJ; Paradiso, L; Powell, KL; Reid, CA; Rosenthal, MA; Wong, D; Yuen, TI	1
Acebes, JJ; Aguilera, C; Alonso, J; Arús, C; Gili, J; Majós, C; Serrallonga, M	1
Bading, JR; Chen, X; Conti, PS; Hou, Y; Park, R; Tohme, M	1
Bergenheim, AT; Henriksson, R; Ronquist, G; Roslin, M; Ungerstedt, U; Waldenström, A	1
Chung, WJ; Lyons, SA; Ogunrinu, T; Sontheimer, H; Weaver, AK	1
Batinić, D; Brozović, A; Buljan, D; Dubravcić, K; Jakopec, S; Karlović, D; Osmak, M; Sorić, J	1
Bhakoo, KK; Florian, CL; Noble, M; Preece, NE; Williams, SR	1
Baunach, S; Gerlach, M; Lan, J; Meixensberger, J; Roosen, K	1
Ito, H; Mizuguchi, J; Nishi, T; Takada, E; Takahashi, M; Yoshihama, I	1

Reviews

8 review(s) available for glutamic acid and Astrocytoma, Grade IV

Article	Year
Altered glutamatergic and inflammatory pathways promote glioblastoma growth, invasion, and seizures: An overview. Journal of the neurological sciences, 2022, 12-15, Volume: 443 Topics: Brain Neoplasms; Glioblastoma; Glioma; Glutamic Acid; Humans; Seizures; Tumor Microenvironment	2022
Pathway analysis of glutamate-mediated, calcium-related signaling in glioma progression. Biochemical pharmacology, 2020, Volume: 176 Topics: Animals; Brain Neoplasms; Calcium; Disease Progression; Glioblastoma; Glutamic Acid; Humans; Neurons; Nitric Oxide; Signal Transduction	2020
Glutamatergic Mechanisms in Glioblastoma and Tumor-Associated Epilepsy. Cells, 2021, 05-17, Volume: 10, Issue:5 Topics: Animals; Anticonvulsants; Antineoplastic Agents; Brain; Brain Neoplasms; Brain Waves; Disease Progression; Epilepsy; Excitatory Amino Acid Antagonists; Glioblastoma; Glutamic Acid; Humans; Receptors, Ionotropic Glutamate; Receptors, Metabotropic Glutamate; Signal Transduction	2021
Glutamate Receptors and Glioblastoma Multiforme: An Old "Route" for New Perspectives. International journal of molecular sciences, 2019, Apr-11, Volume: 20, Issue:7 Topics: Animals; Biomechanical Phenomena; Cell Movement; Central Nervous System Neoplasms; Glioblastoma; Glutamic Acid; Humans; Ion Channels; Neoplasm Invasiveness; Receptors, Glutamate; Receptors, Metabotropic Glutamate; Signal Transduction	2019
Restricted calorie ketogenic diet for the treatment of glioblastoma multiforme. Journal of child neurology, 2013, Volume: 28, Issue:8 Topics: Animals; Brain Neoplasms; Caloric Restriction; Combined Modality Therapy; Diet, Ketogenic; Glioblastoma; Glucose; Glutamic Acid; Humans; United States	2013
A novel treatment strategy for glioblastoma multiforme and glioma associated seizures: increasing glutamate uptake with PPARγ agonists. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2015, Volume: 22, Issue:1 Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Excitatory Amino Acid Transporter 2; Glioblastoma; Glutamic Acid; Humans; PPAR gamma; Seizures	2015
Main path and byways: non-vesicular glutamate release by system xc(-) as an important modifier of glutamatergic neurotransmission. Journal of neurochemistry, 2015, Volume: 135, Issue:6 Topics: Animals; Brain; Brain Neoplasms; Glioblastoma; Glutamic Acid; Humans; Oxidative Stress; Synaptic Transmission	2015
Glutamate and α-ketoglutarate: key players in glioma metabolism. Amino acids, 2017, Volume: 49, Issue:1 Topics: Antimetabolites, Antineoplastic; Brain Neoplasms; Citric Acid Cycle; Gene Expression; Glioblastoma; Glutamic Acid; Humans; Isocitrate Dehydrogenase; Ketoglutaric Acids; Mutation; Neoplasm Grading; Reactive Oxygen Species	2017

Trials

1 trial(s) available for glutamic acid and Astrocytoma, Grade IV

Article	Year
Metabolic manipulation of glioblastoma in vivo by retrograde microdialysis of L-2, 4 diaminobutyric acid (DAB). Journal of neuro-oncology, 2006, Volume: 80, Issue:3 Topics: Aged; Aminobutyrates; Antimetabolites, Antineoplastic; Brain Neoplasms; Catheters, Indwelling; Dose-Response Relationship, Drug; Female; Glioblastoma; Glutamic Acid; Glycerol; Humans; Infusions, Intralesional; Male; Microdialysis; Middle Aged; Monitoring, Ambulatory; Stereotaxic Techniques; Taurine; Treatment Outcome	2006

Article

Year

Metabolic manipulation of glioblastoma in vivo by retrograde microdialysis of L-2, 4 diaminobutyric acid (DAB).

Journal of neuro-oncology, 2006, Volume: 80, Issue:3

Topics: Aged; Aminobutyrates; Antimetabolites, Antineoplastic; Brain Neoplasms; Catheters, Indwelling; Dose-Response Relationship, Drug; Female; Glioblastoma; Glutamic Acid; Glycerol; Humans; Infusions, Intralesional; Male; Microdialysis; Middle Aged; Monitoring, Ambulatory; Stereotaxic Techniques; Taurine; Treatment Outcome

2006

Other Studies

58 other study(ies) available for glutamic acid and Astrocytoma, Grade IV

Article	Year
Thiamine Protects Glioblastoma Cells against Glutamate Toxicity by Suppressing Oxidative/Endoplasmic Reticulum Stress. Chemical & pharmaceutical bulletin, 2021, Volume: 69, Issue:9 Topics: Animals; Cell Survival; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Glioblastoma; Glutamic Acid; Oxidative Stress; Protective Agents; Rats; Thiamine; Tumor Cells, Cultured	2021
The expression of glutamate metabolism modulators in the intracranial tumors and glioblastoma cell line. Molecular biology reports, 2022, Volume: 49, Issue:2 Topics: Adolescent; Adult; Aged; Astrocytes; Brain Neoplasms; Cell Line; Child; Child, Preschool; Female; Gene Expression; Gene Expression Regulation, Neoplastic; Glioblastoma; Glutamate Dehydrogenase; Glutamate-Ammonia Ligase; Glutamic Acid; Humans; Male; Middle Aged; Mitochondrial Proteins; Neuroglia; Retrospective Studies; Sirtuins	2022
PI3K Pathway Inhibition with NVP-BEZ235 Hinders Glycolytic Metabolism in Glioblastoma Multiforme Cells. Cells, 2021, 11-07, Volume: 10, Issue:11 Topics: Brain Neoplasms; Cell Line, Tumor; Forkhead Box Protein O1; Gene Expression Regulation, Neoplastic; Gene Ontology; Glioblastoma; Glucose; Glutamic Acid; Glycolysis; Humans; Imidazoles; Kaplan-Meier Estimate; Lactic Acid; NAD; Phosphatidylinositol 3-Kinases; Prognosis; Protein Kinase Inhibitors; Quinolines; Signal Transduction	2021
Glutamic Acid and Total Creatine as Predictive Markers for Epilepsy in Glioblastoma by Using Magnetic Resonance Spectroscopy Before Surgery. World neurosurgery, 2022, Volume: 160 Topics: Creatine; Epilepsy; Glioblastoma; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Quality of Life; Reproducibility of Results	2022
Quantitative measurement of peritumoral concentrations of glutamate, N-acetyl aspartate, and lactate on magnetic resonance spectroscopy predicts glioblastoma-related refractory epilepsy. Acta neurochirurgica, 2022, Volume: 164, Issue:12 Topics: Aspartic Acid; Creatine; Drug Resistant Epilepsy; Epilepsy, Temporal Lobe; Glioblastoma; Glutamic Acid; Humans; Lactic Acid; Magnetic Resonance Spectroscopy	2022
The Regulation of GLT-1 Degradation Pathway by SIRT4. Neurochemical research, 2023, Volume: 48, Issue:9 Topics: Astrocytes; Excitatory Amino Acid Transporter 2; Glioblastoma; Glutamic Acid; Humans; Mitochondrial Proteins; Neurons; Proteolysis; Sirtuins; Ubiquitination	2023
Nuclear Translocation of LDHA Promotes the Catabolism of BCAAs to Sustain GBM Cell Proliferation through the TxN Antioxidant Pathway. International journal of molecular sciences, 2023, May-27, Volume: 24, Issue:11 Topics: Amino Acids, Branched-Chain; Animals; Antioxidants; Cell Proliferation; Glioblastoma; Glutamic Acid; Humans; Lactate Dehydrogenase 5; Mice; Mice, Nude; Thioredoxins	2023
Novel therapeutic strategies in glioma targeting glutamatergic neurotransmission. Brain research, 2023, 11-01, Volume: 1818 Topics: Anticonvulsants; Brain Neoplasms; Glioblastoma; Glioma; Glutamic Acid; Humans; Synaptic Transmission	2023
Mitochondrial glutamate transporter SLC25A22 uni-directionally export glutamate for metabolic rewiring in radioresistant glioblastoma. International journal of biological macromolecules, 2023, Dec-31, Volume: 253, Issue:Pt 8 Topics: Brain Neoplasms; Cell Line, Tumor; Glioblastoma; Glutamic Acid; Humans; Mitochondria; Mitochondrial Membrane Transport Proteins; Proline; Radiation Tolerance	2023
Glioblastoma invasion and NMDA receptors: A novel prospect. Physiology international, 2019, Sep-01, Volume: 106, Issue:3 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Cell Line, Tumor; Cell Movement; Dizocilpine Maleate; Glioblastoma; Glutamic Acid; Humans; Neoplasm Invasiveness; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Tumor Microenvironment; Up-Regulation	2019
Dysregulation of Glutamate Transport Enhances Treg Function That Promotes VEGF Blockade Resistance in Glioblastoma. Cancer research, 2020, 02-01, Volume: 80, Issue:3 Topics: Animals; Antineoplastic Agents, Immunological; Apoptosis; Bevacizumab; CD8-Positive T-Lymphocytes; Cell Proliferation; Drug Resistance, Neoplasm; Female; Glioblastoma; Glutamic Acid; Humans; Lymphocytes, Tumor-Infiltrating; Mice; Mice, Inbred C57BL; T-Lymphocytes, Regulatory; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A	2020
Nature biomedical engineering, 2020, Volume: 4, Issue:3 Topics: Animals; Brain; Brain Mapping; Cell Line, Tumor; Diagnostic Imaging; gamma-Aminobutyric Acid; Glioblastoma; Glioma; Glucose; Glutamic Acid; Glutamine; Glycolysis; Kinetics; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Rats; Staining and Labeling	2020
Regulation of branched-chain amino acid metabolism by hypoxia-inducible factor in glioblastoma. Cellular and molecular life sciences : CMLS, 2021, Volume: 78, Issue:1 Topics: Amino Acids, Branched-Chain; Basic Helix-Loop-Helix Transcription Factors; Brain Neoplasms; Cell Hypoxia; Cell Proliferation; Cells, Cultured; CRISPR-Cas Systems; Gene Expression Regulation, Neoplastic; Gene Knockout Techniques; Glioblastoma; Glutamic Acid; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Large Neutral Amino Acid-Transporter 1; Protein Binding; Transaminases	2021
Different Mechanisms Underlie the Metabolic Response of GBM Stem-Like Cells to Ionizing Radiation: Biological and MRS Studies on Effects of Photons and Carbon Ions. International journal of molecular sciences, 2020, Jul-21, Volume: 21, Issue:14 Topics: Brain Neoplasms; Cell Line, Tumor; G2 Phase Cell Cycle Checkpoints; gamma-Aminobutyric Acid; Glioblastoma; Glucose; Glutamic Acid; Humans; Ions; Lactic Acid; Magnetic Resonance Spectroscopy; Neoplastic Stem Cells; Phosphocreatine; Photons; Radiation, Ionizing	2020
Brain Tumor Stem Cell Dependence on Glutaminase Reveals a Metabolic Vulnerability through the Amino Acid Deprivation Response Pathway. Cancer research, 2020, 12-15, Volume: 80, Issue:24 Topics: Amino Acids; Astrocytes; Benzeneacetamides; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Citric Acid Cycle; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Glioblastoma; Glutamic Acid; Glutaminase; Humans; Neoplastic Stem Cells; Signal Transduction; Thiadiazoles	2020
Bioinformatics and machine learning methodologies to identify the effects of central nervous system disorders on glioblastoma progression. Briefings in bioinformatics, 2021, 09-02, Volume: 22, Issue:5 Topics: Atlases as Topic; Brain Neoplasms; Central Nervous System; Computational Biology; Datasets as Topic; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Ontology; Gene Regulatory Networks; Glioblastoma; Glutamic Acid; Humans; Kaplan-Meier Estimate; Machine Learning; Molecular Sequence Annotation; Neoplasm Proteins; Proportional Hazards Models; Signal Transduction	2021
Metabolic and inflammatory reprogramming of macrophages by ONC201 translates in a pro-inflammatory environment even in presence of glioblastoma cells. European journal of immunology, 2021, Volume: 51, Issue:5 Topics: Antineoplastic Agents; Cell Line, Tumor; Drug Resistance, Neoplasm; Energy Metabolism; Gene Expression Regulation, Neoplastic; Glioblastoma; Glutamic Acid; Humans; Imidazoles; Macrophages; Mitochondria; Pyridines; Pyrimidines; Receptors, Dopamine D2; Receptors, Dopamine D5; Signal Transduction; Transcription Factor CHOP; Tumor Microenvironment	2021
The investigation of glutamate transporter 1 (GLT-1) degradation pathway in glioblastoma cells. Molecular biology reports, 2021, Volume: 48, Issue:4 Topics: Brain Neoplasms; Cell Line, Tumor; Excitatory Amino Acid Transporter 2; Glioblastoma; Glutamic Acid; Humans; Proteolysis; Ubiquitin	2021
Blood glutamate scavengers increase pro-apoptotic signaling and reduce metastatic melanoma growth in-vivo. Scientific reports, 2021, 07-19, Volume: 11, Issue:1 Topics: Animals; Apoptosis; Aspartate Aminotransferase, Cytoplasmic; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Drug Therapy, Combination; Glioblastoma; Glutamic Acid; Humans; Melanoma; Mice; Mice, Inbred C57BL; Molecular Targeted Therapy; Oxaloacetic Acid; Recombinant Proteins; Signal Transduction; Tumor Microenvironment	2021
Inhibition of metabotropic glutamate receptor III facilitates sensitization to alkylating chemotherapeutics in glioblastoma. Cell death & disease, 2021, 07-21, Volume: 12, Issue:8 Topics: Amino Acids; Antineoplastic Agents, Alkylating; Cell Death; Cell Line, Tumor; Cell Survival; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Glioblastoma; Glutamic Acid; Humans; Kinetics; Neoadjuvant Therapy; Receptors, Metabotropic Glutamate; Temozolomide; Tumor Microenvironment; Xanthenes	2021
Synergy between glutamate modulation and anti-programmed cell death protein 1 immunotherapy for glioblastoma. Journal of neurosurgery, 2022, Feb-01, Volume: 136, Issue:2 Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Glioblastoma; Glutamic Acid; Immunotherapy; Mice; Mice, Inbred C57BL; Tumor Microenvironment	2022
Proline oxidase controls proline, glutamate, and glutamine cellular concentrations in a U87 glioblastoma cell line. PloS one, 2018, Volume: 13, Issue:4 Topics: Cell Line, Tumor; Chromatography, High Pressure Liquid; Down-Regulation; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Genetic Vectors; Glioblastoma; Glutamic Acid; Glutamine; Humans; Microscopy, Fluorescence; Mitochondria; Mutagenesis, Site-Directed; Proline; Proline Oxidase	2018
Altered function of the glutamate-aspartate transporter GLAST, a potential therapeutic target in glioblastoma. International journal of cancer, 2019, 05-15, Volume: 144, Issue:10 Topics: Amino Acid Transport System X-AG; Animals; Apoptosis; Aspartic Acid; Astrocytes; Benzopyrans; Cell Line, Tumor; Cell Membrane; Excitatory Amino Acid Transporter 1; Female; Glioblastoma; Glioma; Glutamic Acid; Humans; Mice; Mice, Inbred C57BL; Protein Transport; Sodium-Potassium-Exchanging ATPase	2019
AMPA receptor antagonist perampanel affects glioblastoma cell growth and glutamate release in vitro. PloS one, 2019, Volume: 14, Issue:2 Topics: Anticonvulsants; Antineoplastic Agents; Apoptosis; Brain; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Epilepsy; Glioblastoma; Glutamic Acid; Humans; Nitriles; Pyridones; Receptors, AMPA; Seizures; Up-Regulation; Valproic Acid	2019
The cystine/glutamate antiporter xCT is a key regulator of EphA2 S897 phosphorylation under glucose-limited conditions. Cellular signalling, 2019, Volume: 62 Topics: Amino Acid Transport System y+; Antiporters; Cell Line, Tumor; Cell Movement; Cell Survival; Cystine; Gene Expression Regulation, Neoplastic; Glioblastoma; Glucose; Glutamic Acid; Humans; MAP Kinase Signaling System; Phosphorylation; Reactive Oxygen Species; Receptor, EphA2; Serine	2019
Synergistic inhibition of survival, proliferation, and migration of U87 cells with a combination of LY341495 and Iressa. PloS one, 2013, Volume: 8, Issue:5 Topics: Amino Acids; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Gefitinib; Glioblastoma; Glutamic Acid; Humans; Quinazolines; Riluzole; Xanthenes	2013
Intratumoral heterogeneity of genomic imbalance in a case of epithelioid glioblastoma with BRAF V600E mutation. Brain pathology (Zurich, Switzerland), 2014, Volume: 24, Issue:3 Topics: Brain Neoplasms; DNA Mutational Analysis; Glioblastoma; Glutamic Acid; Humans; Isocitrate Dehydrogenase; Male; Polymorphism, Single Nucleotide; Proto-Oncogene Proteins B-raf; Valine; Young Adult	2014
Epithelioid glioblastoma arising from pleomorphic xanthoastrocytoma with the BRAF V600E mutation. Brain tumor pathology, 2014, Volume: 31, Issue:3 Topics: Amino Acid Substitution; Astrocytoma; Brain Neoplasms; Child; Female; Glioblastoma; Glutamic Acid; Humans; Magnetic Resonance Imaging; Mutation; Neoplasms, Second Primary; Proto-Oncogene Proteins B-raf; Time Factors; Valine	2014
Kynurenic acid inhibits proliferation and migration of human glioblastoma T98G cells. Pharmacological reports : PR, 2014, Volume: 66, Issue:1 Topics: Adult; Aged; Benzodiazepines; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Female; Glioblastoma; Glutamic Acid; Humans; Kynurenic Acid; Male; Middle Aged	2014
Acetate is a bioenergetic substrate for human glioblastoma and brain metastases. Cell, 2014, Dec-18, Volume: 159, Issue:7 Topics: Acetate-CoA Ligase; Acetates; Animals; Brain Neoplasms; Citric Acid Cycle; Disease Models, Animal; Glioblastoma; Glutamic Acid; Humans; Mice; Neoplasm Metastasis	2014
Arundic acid attenuates retinal ganglion cell death by increasing glutamate/aspartate transporter expression in a model of normal tension glaucoma. Cell death & disease, 2015, Mar-19, Volume: 6 Topics: Animals; Caprylates; Cell Death; Excitatory Amino Acid Transporter 1; Gene Expression Regulation; Glaucoma; Glioblastoma; Glutamic Acid; Humans; Mice; Nerve Degeneration; Optic Nerve; Retinal Ganglion Cells	2015
Compensatory glutamine metabolism promotes glioblastoma resistance to mTOR inhibitor treatment. The Journal of clinical investigation, 2015, Volume: 125, Issue:4 Topics: Aged; Animals; Antineoplastic Combined Chemotherapy Protocols; Benzophenanthridines; Brain Neoplasms; Cell Line, Tumor; Citric Acid Cycle; Drug Resistance, Neoplasm; Drug Synergism; Energy Metabolism; Gas Chromatography-Mass Spectrometry; Glioblastoma; Glutamic Acid; Glutaminase; Glutamine; Glycolysis; Humans; Indoles; Ketoglutaric Acids; Magnetic Resonance Spectroscopy; Male; Metabolome; Mice; Mice, Inbred BALB C; Mice, Nude; Molecular Targeted Therapy; Neoplasm Proteins; Protein Kinase Inhibitors; Purines; RNA, Small Interfering; Rotarod Performance Test; Signal Transduction; Temporal Lobe; TOR Serine-Threonine Kinases; Xenograft Model Antitumor Assays	2015
IDH1 Mutation Induces Reprogramming of Pyruvate Metabolism. Cancer research, 2015, Aug-01, Volume: 75, Issue:15 Topics: Astrocytes; Cell Line, Tumor; Cell Proliferation; Dichloroacetic Acid; Down-Regulation; Glioblastoma; Glutamic Acid; Glutarates; Humans; Isocitrate Dehydrogenase; Magnetic Resonance Spectroscopy; Mutation; Pyruvate Dehydrogenase Complex; Pyruvates	2015
The peroxisome proliferator activated receptor gamma agonist pioglitazone increases functional expression of the glutamate transporter excitatory amino acid transporter 2 (EAAT2) in human glioblastoma cells. Oncotarget, 2015, Aug-28, Volume: 6, Issue:25 Topics: Anilides; Animals; Brain; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Excitatory Amino Acid Transporter 2; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glioblastoma; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Neoplasm Transplantation; Pioglitazone; PPAR gamma; Rats; Rats, Wistar; Seizures; Thiazolidinediones	2015
Glioblastoma cells induce differential glutamatergic gene expressions in human tumor-associated microglia/macrophages and monocyte-derived macrophages. Cancer biology & therapy, 2015, Volume: 16, Issue:8 Topics: Antigens, CD; Antigens, Differentiation, Myelomonocytic; Astrocytes; Brain Neoplasms; Calcium-Binding Proteins; CD11b Antigen; Coculture Techniques; DNA-Binding Proteins; Gene Expression Regulation; Glioblastoma; Glutamic Acid; Humans; Leukocyte Common Antigens; Macrophages; Microfilament Proteins; Microglia; Receptors, AMPA; Tumor Cells, Cultured	2015
Alterations in cellular metabolome after pharmacological inhibition of Notch in glioblastoma cells. International journal of cancer, 2016, Mar-01, Volume: 138, Issue:5 Topics: Brain Neoplasms; Cell Line, Tumor; Cyclic S-Oxides; Glioblastoma; Glutamic Acid; Glutaminase; Homeostasis; Humans; Metabolome; Receptors, Notch; Thiadiazoles	2016
Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma. Nature cell biology, 2015, Volume: 17, Issue:12 Topics: Animals; Astrocytes; Blotting, Western; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Cells, Cultured; Citric Acid Cycle; Coculture Techniques; Female; Glioblastoma; Glutamate-Ammonia Ligase; Glutamic Acid; Glutamine; Humans; Male; Mice, Inbred NOD; Mice, SCID; Models, Biological; Neoplastic Stem Cells; Nucleotides; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Transplantation, Heterologous	2015
Pilot Preclinical and Clinical Evaluation of (4S)-4-(3-[18F]Fluoropropyl)-L-Glutamate (18F-FSPG) for PET/CT Imaging of Intracranial Malignancies. PloS one, 2016, Volume: 11, Issue:2 Topics: Adult; Aged; Animals; Brain Neoplasms; Case-Control Studies; Cell Line, Tumor; Disease Models, Animal; Female; Fluorodeoxyglucose F18; Glioblastoma; Glutamic Acid; Heterografts; Humans; Male; Middle Aged; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Tomography, X-Ray Computed; Tyrosine	2016
Advanced MRI increases the diagnostic accuracy of recurrent glioblastoma: Single institution thresholds and validation of MR spectroscopy and diffusion weighted MR imaging. NeuroImage. Clinical, 2016, Volume: 11 Topics: Adult; Aged; Aspartic Acid; Brain Neoplasms; Choline; Cohort Studies; Diffusion Magnetic Resonance Imaging; Female; Glioblastoma; Glutamic Acid; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Spectroscopy; Male; Middle Aged; ROC Curve; Statistics, Nonparametric	2016
Integrative Network-based Analysis of Magnetic Resonance Spectroscopy and Genome Wide Expression in Glioblastoma multiforme. Scientific reports, 2016, 06-28, Volume: 6 Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain Neoplasms; Computational Biology; Creatine; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genome-Wide Association Study; Glioblastoma; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neoplasm Proteins; Neurons; Oligodendroglia; Prognosis; Prospective Studies; Survival Analysis	2016
Glutamate-Mediated Blood-Brain Barrier Opening: Implications for Neuroprotection and Drug Delivery. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016, 07-20, Volume: 36, Issue:29 Topics: 4-Aminopyridine; Adult; Aged; Animals; Blood-Brain Barrier; Brain Neoplasms; Disease Models, Animal; Double-Blind Method; Female; Glioblastoma; Glutamic Acid; Humans; Male; Middle Aged; Neuroprotective Agents; Permeability; Potassium Channel Blockers; Rats; Rats, Sprague-Dawley; Seizures; Stroke; Treatment Outcome	2016
In search of druggable targets for GBM amino acid metabolism. BMC cancer, 2017, 02-28, Volume: 17, Issue:1 Topics: Amino Acids; Brain Neoplasms; Databases, Genetic; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glioblastoma; Glutamic Acid; Humans; Metabolic Networks and Pathways; Prognosis; Survival Analysis; Urea	2017
Two distinct tumor phenotypes isolated from glioblastomas show different MRS characteristics. NMR in biomedicine, 2008, Volume: 21, Issue:8 Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Choline; Glioblastoma; Glutamic Acid; Magnetic Resonance Spectroscopy; Phenotype; Rats; Rats, Nude	2008
Attenuated AMPA receptor expression allows glioblastoma cell survival in glutamate-rich environment. PloS one, 2009, Jun-18, Volume: 4, Issue:6 Topics: Animals; Brain; Brain Neoplasms; Calcium; Cell Line, Tumor; Cell Proliferation; Cell Survival; Gene Expression Regulation, Neoplastic; Glioblastoma; Glutamic Acid; Humans; Immunohistochemistry; Mice; Receptors, AMPA; Sodium	2009
Glutamate promotes cell growth by EGFR signaling on U-87MG human glioblastoma cell line. Pathology oncology research : POR, 2010, Volume: 16, Issue:2 Topics: Cell Line, Tumor; Cell Proliferation; ErbB Receptors; Glioblastoma; Glutamic Acid; Humans; Image Processing, Computer-Assisted; Immunohistochemistry; Proto-Oncogene Proteins c-akt; Receptors, AMPA; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction	2010
Stripe-like increase of rCBV beyond the visible border of glioblastomas: site of tumor infiltration growing after neurosurgery. Journal of neuro-oncology, 2011, Volume: 103, Issue:3 Topics: Adult; Aged; Asparagine; Blood Volume; Brain Neoplasms; Cerebrovascular Circulation; Contrast Media; Creatine; Female; Glioblastoma; Glutamic Acid; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neurosurgical Procedures; Postoperative Complications; Reproducibility of Results; Statistics, Nonparametric; Time Factors; Tritium; Young Adult	2011
[2,4-(13)C]β-hydroxybutyrate metabolism in astrocytes and C6 glioblastoma cells. Neurochemical research, 2011, Volume: 36, Issue:8 Topics: 3-Hydroxybutyric Acid; Animals; Aspartic Acid; Astrocytes; Brain Neoplasms; Citric Acid Cycle; Diet, Ketogenic; Glioblastoma; Glucose; Glutamic Acid; Glutamine; Humans; Ketone Bodies; Lactic Acid; Mice; Tumor Cells, Cultured	2011
Glucose metabolism via the pentose phosphate pathway, glycolysis and Krebs cycle in an orthotopic mouse model of human brain tumors. NMR in biomedicine, 2012, Volume: 25, Issue:10 Topics: Animals; Brain Neoplasms; Carcinoma, Renal Cell; Citric Acid Cycle; Disease Models, Animal; gamma-Aminobutyric Acid; Glioblastoma; Glucose; Glutamate Decarboxylase; Glutamic Acid; Glycolysis; Humans; Kidney Neoplasms; Lactic Acid; Magnetic Resonance Imaging; Mice; Pentose Phosphate Pathway; Positron-Emission Tomography; Xenograft Model Antitumor Assays	2012
Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse human glioblastomas in the mouse brain in vivo. Cell metabolism, 2012, Jun-06, Volume: 15, Issue:6 Topics: Animals; Brain Neoplasms; Glioblastoma; Gluconeogenesis; Glucose; Glutamate-Ammonia Ligase; Glutamic Acid; Glutaminase; Glutamine; Glycolysis; Humans; Mice; Mice, Inbred NOD; Mice, SCID; Mitochondria; Neoplasm Transplantation; Neostriatum; Oxidation-Reduction; Phenotype; Pyruvate Carboxylase; Statistics, Nonparametric; Tumor Cells, Cultured	2012
Effects of 18-kDa translocator protein knockdown on gene expression of glutamate receptors, transporters, and metabolism, and on cell viability affected by glutamate. Pharmacogenetics and genomics, 2012, Volume: 22, Issue:8 Topics: Animals; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Glioblastoma; Glutamic Acid; Humans; Oligonucleotide Array Sequence Analysis; Rats; Receptors, GABA; Receptors, Glutamate; RNA, Small Interfering	2012
Glutamate is associated with a higher risk of seizures in patients with gliomas. Neurology, 2012, Aug-28, Volume: 79, Issue:9 Topics: Adult; Amino Acid Transport System y+; Astrocytoma; Blotting, Western; Cohort Studies; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Female; Glioblastoma; Glioma; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Humans; Logistic Models; Male; Middle Aged; Odds Ratio; Retrospective Studies; Risk Factors; Seizures; Supratentorial Neoplasms; Vesicular Glutamate Transport Proteins	2012
Adult primitive neuroectodermal tumor: proton MR spectroscopic findings with possible application for differential diagnosis. Radiology, 2002, Volume: 225, Issue:2 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alanine; Astrocytoma; Brain; Brain Neoplasms; Diagnosis, Differential; Female; Glioblastoma; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Meningeal Neoplasms; Meningioma; Middle Aged; Neuroectodermal Tumors, Primitive; Prospective Studies; Retrospective Studies	2002
Micro-PET imaging of alphavbeta3-integrin expression with 18F-labeled dimeric RGD peptide. Molecular imaging, 2004, Volume: 3, Issue:2 Topics: Animals; Brain; Capillaries; Cells, Cultured; Dimerization; Endothelium, Vascular; Female; Fluorine Radioisotopes; Glioblastoma; Glutamic Acid; Humans; Integrin alphaVbeta3; Isotope Labeling; Kidney; Mice; Mice, Nude; Molecular Structure; Neoplasm Transplantation; Oligopeptides; Peptides, Cyclic; Positron-Emission Tomography; Radiopharmaceuticals; Reference Standards; Time Factors; Transplantation, Heterologous	2004
Autocrine glutamate signaling promotes glioma cell invasion. Cancer research, 2007, Oct-01, Volume: 67, Issue:19 Topics: Amino Acid Transport System y+; Animals; Brain Neoplasms; Calcium; Cell Line, Tumor; Cell Movement; Female; Glioblastoma; Glutamic Acid; Humans; Mice; Mice, Nude; Neoplasm Invasiveness; Random Allocation; Receptors, AMPA; Signal Transduction; Sulfasalazine	2007
Lithium effect on glutamate induced damage in glioblastoma cells. Collegium antropologicum, 2008, Volume: 32 Suppl 1 Topics: Antimanic Agents; Apoptosis; Blotting, Western; Cyclin-Dependent Kinase Inhibitor p21; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glioblastoma; Glutamic Acid; Humans; Inhibitor of Apoptosis Proteins; Lithium Chloride; Microtubule-Associated Proteins; Neoplasm Proteins; Survivin; Tumor Cells, Cultured	2008
Characteristic metabolic profiles revealed by 1H NMR spectroscopy for three types of human brain and nervous system tumours. NMR in biomedicine, 1995, Volume: 8, Issue:6 Topics: Alanine; Amino Acids; Brain Neoplasms; Choline; Chromatography, High Pressure Liquid; Creatine; Glioblastoma; Glutamic Acid; Humans; Magnetic Resonance Spectroscopy; Meningioma; Neuroblastoma; Tumor Cells, Cultured	1995
Intraoperative microdialysis and tissue-pO2 measurement in human glioma. Acta neurochirurgica. Supplement, 1998, Volume: 71 Topics: Aspartic Acid; Brain Edema; Brain Neoplasms; Cell Death; Female; Frontal Lobe; Glioblastoma; Glutamic Acid; Humans; Male; Microdialysis; Monitoring, Intraoperative; Oxygen Consumption; Prognosis; Temporal Lobe	1998
Participation of Bcl-2/Bax-alpha in glutamate-induced apoptosis of human glioblastoma cells. Journal of neuro-oncology, 1999, Volume: 44, Issue:2 Topics: Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Down-Regulation; Genetic Variation; Glioblastoma; Glutamic Acid; Humans; Osmolar Concentration; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Tumor Cells, Cultured	1999