glutamic acid has been researched along with Amyotrophic Lateral Sclerosis in 260 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (1.15) | 18.7374 |
| 1990's | 50 (19.23) | 18.2507 |
| 2000's | 105 (40.38) | 29.6817 |
| 2010's | 84 (32.31) | 24.3611 |
| 2020's | 18 (6.92) | 2.80 |
| Authors | Studies |
|---|---|
| Schiel, KA | 1 |
| Chang, CY; Chen, MF; Chiou, TW; Chiu, IM; Harn, HJ; Ho, TJ; Li, X; Lin, SZ; Liu, CA; Su, HL; Ting, HC; Tsai, YJ; Yang, HI | 1 |
| Cheng, Y; Cui, L; Li, X; Yang, L; Zhu, Y | 1 |
| Bongarzone, S; Fontana, IC; Gee, A; Souza, DG; Souza, DO; Zimmer, ER | 1 |
| Carreira, RB; Costa, SL; da Silva, VDA; de Oliveira, JVR; de Oliveira, LMG; do Nascimento, RP; Dos Santos Souza, C; Trias, E | 1 |
| Dahlmanns, JK; Dahlmanns, M; Savaskan, N; Steiner, HH; Yakubov, E | 1 |
| Ari, C; D'Agostino, DP; DeBlasi, JM; Koutnik, AP; Landon, CS; Ramirez, M; Rogers, CQ | 1 |
| Balbi, M; Bonanno, G; Bonifacino, T; Cerminara, M; Gallia, E; Jafar-Nejad, P; Milanese, M; Musante, I; Provenzano, F; Puliti, A; Ravera, S; Rigo, F; Tessitore, S; Torazza, C; Usai, C; Van Den Bosch, L | 1 |
| Ates, G; Beckers, P; Belo do Nascimento, I; Desmet, N; Hermans, E; Massie, A | 1 |
| Aureli, M; Callizot, N; Carsana, EV; Chiricozzi, E; Ciampa, MG; Di Biase, E; Fazzari, M; Henriques, A; Loberto, N; Lunghi, G; Mari, L; Mauri, L; Sonnino, S; Spedding, M | 1 |
| Bonanno, G; Bonifacino, T; Milanese, M; Provenzano, F; Torazza, C | 1 |
| Blicher, JU; Eskildsen, SF; Figlewski, K; Møller, AT; Near, J; Stærmose, TG | 1 |
| Behar, O; Belzer, V; Ben-Dor, I; Birger, A; Casden, N; Feldman, E; Galun, E; Gil, Y; Izrael, M; Ottolenghi, M; Perez, L; Reubinoff, B; Steiner, D; Sweetat, S; Turetsky, T | 1 |
| Kakita, A; Kato, Y; Kazama, M; Kitagawa, K; Masui, K; Niida-Kawaguchi, M; Noguchi, N; Sawada, T; Shibata, N; Watabe, K; Yamamoto, T | 1 |
| Abrudan, J; Barkhaus, PE; Demos, W; Ebert, AD; Fee, D; Mejaki, M; Santarriaga, S; Seminary, ER; Urrutia, RA; Wheeler, L; Zimmermann, MT | 1 |
| Atchison, WD; Sabo, SL; Sceniak, MP; Spitsbergen, JB; Yuan, Y | 1 |
| Casarotto, E; Chierichetti, M; Crippa, V; Cristofani, R; Ferrari, V; Galbiati, M; Messi, E; Piccolella, M; Poletti, A; Rusmini, P; Tedesco, B | 1 |
| Kakita, A; Kato, Y; Kazama, M; Kitagawa, K; Masui, K; Niida-Kawaguchi, M; Noguchi, N; Shibata, N; Urano, Y; Watabe, K; Yamamoto, T | 1 |
| Balbi, M; Bertola, N; Bonanno, G; Bonifacino, T; Ferrando, S; Frumento, G; Kumar, M; Milanese, M; Nguyen, TPN; Profumo, A; Provenzano, F; Ravera, S; Torazza, C; Viale, M; Zerbo, AR | 1 |
| Katagi, M; Kojima, H; Nakae, Y; Ohashi, N; Okano, J; Suzuki, Y; Terashima, T | 1 |
| Foran, E; Ghosh, B; Lepore, AC; Pasinelli, P; Rosenblum, LT; Shamamandri-Markandaiah, S; Trotti, D | 1 |
| Atchison, WD; Bailey, JM; Colón-Rodríguez, A | 1 |
| Binder, DK; Hubbard, JA | 1 |
| Atassi, N; Cernasov, P; Keil, B; Lawson, R; Long, CJ; Murphy, A; Paganoni, S; Ratai, EM; Ratti, E; Rosen, B; Salibi, N; Seethamraju, R; Triantafyllou, C; Xu, M | 1 |
| Jinno, S; Kadomatsu, K; Kira, JI; Ohgomori, T; Takeuchi, H; Yamasaki, R | 1 |
| Johann, S | 1 |
| Bonanno, G; Bonifacino, T; Bossi, S; Cattaneo, L; Conti, F; Gallia, E; Melone, M; Milanese, M; Musante, I; Provenzano, F; Puliti, A; Usai, C | 1 |
| Buonvicino, D; Cavone, L; Chiarugi, A; Felici, R; Gerace, E; Lapucci, A; Mai, A; Valente, S; Zwergel, C | 1 |
| Rosenblum, LT; Trotti, D | 1 |
| Aiello, I; Chiara, M; Ciaccia, L; D'Erchia, AM; Gallo, A; Horner, DS; Locatelli, F; Manzari, C; Mastropasqua, F; Nicchia, GP; Pesole, G; Picardi, E; Pisani, F; Raho, S; Svelto, M; Valletti, A | 1 |
| Ishigaki, S; Iwasaki, Y; Katsuno, M; Masuda, M; Mimuro, M; Riku, Y; Sobue, G; Watanabe, H; Yoshida, M | 1 |
| Antonini, A; Biocca, S; Caioli, S; Canu, N; Saba, L; Vindigni, G; Zona, C | 1 |
| Doyen, PJ; Hermans, E; Opsomer, R; Peeters, M; Vergouts, M | 1 |
| Feiguin, F; Garcia, R; Grilli, F; Guarnaccia, C; Holodkov, N; Klima, R; Nizzardo, M; Rizzo, F; Romano, G | 1 |
| Dougherty, JD; Hoye, ML; Jensen, LA; Lake, AM; Maragakis, NJ; Miller, TM; Reddy, LV; Regan, MR; Richard, JP; Rothstein, JD; Vidensky, S | 1 |
| Goli, D; Maya, S; Prakash, T | 1 |
| Baskoylu, SN; Dimitriadi, M; Grosser, S; Hart, AC; Kim, S; Lins, J; O'Hern, P; Schuch, K; Simon, J; Yanagi, KS; Yersak, J | 1 |
| Kamm, RD; Osaki, T; Uzel, SGM | 1 |
| Bissaro, M; Federico, S; Moro, S; Salmaso, V; Spalluto, G; Sturlese, M | 1 |
| Cheong, I; Deelchand, DK; Eberly, LE; Guliani, G; Manousakis, G; Marjańska, M; Öz, G; Walk, D | 1 |
| French, PW; Guillemin, GJ; Ludowyke, R | 1 |
| Bonanno, S; Markandaiah, SS; Mohamed, LA; Pasinelli, P; Trotti, D | 1 |
| Baron, DM; Bosco, DA; Fallini, C; Gall, KV; Landers, JE; Lin, YC; Tischbein, M | 1 |
| Cleveland, DW; Da Cruz, S; Huang, TY; Jiang, LL; Li, X; Liu, T; Long, T; Pina-Crespo, J; Ravits, J; Rodriguez, MJ; Xu, H; Xu, W; Yu, H; Zhang, D; Zhao, Y; Zhou, L; Zhu, B | 1 |
| Atkin, JD; Halloran, MA; Parakh, S; Soo, KY; Spencer, DM | 1 |
| Barker, PB; Callaghan, BC; Carlos, RC; Edden, RA; Feldman, EL; Foerster, BR; Mohamed, MA; Petrou, M; Pomper, MG; Welsh, RC | 1 |
| Bogush, AI; Foran, E; Rosenblum, L; Trotti, D | 1 |
| Bennett, CF; Blackshaw, S; Daley, EL; Donnelly, CJ; Fines, DM; Haeusler, AR; Heusler, AR; Hoover, B; Maragakis, N; Mistry, NA; Petrucelli, L; Pham, JT; Poth, EM; Rigo, F; Rothstein, JD; Sattler, R; Tienari, PJ; Traynor, BJ; Vidensky, S; Wang, J; Zhang, PW | 1 |
| Genç, B; Özdinler, PH | 1 |
| Bonanno, G; Bonifacino, T; Carminati, E; Conti, F; Giribaldi, F; Melone, M; Milanese, M; Musante, I; Puliti, A; Rossi, PI; Vergani, L; Voci, A | 1 |
| Alzweiri, M; Bardaweel, SK; Ishaqat, AA | 1 |
| Langford, SJ; Wood, LK | 1 |
| Bogush, A; Foran, E; Pasinelli, P; Rosenblum, L; Trotti, D | 1 |
| Kiernan, MC; Menon, P; Vucic, S | 1 |
| Blasco, H; Corcia, P; Gordon, PH; Mavel, S | 1 |
| Benfenati, F; Bonanno, G; Bonifacino, T; Cattaneo, L; Fedele, E; Milanese, M; Rebosio, C; Usai, C | 1 |
| Hala, TJ; Lepore, AC; Li, K; Poulsen, DJ; Seetharam, S; Wright, MC | 1 |
| Barhum, Y; Lev, N; Lotan, I; Offen, D; Steiner, I | 1 |
| King, AE; Kirkcaldie, MT; Vickers, JC; Woodhouse, A | 1 |
| Austin, A; Baloh, RH; Bell, S; Bogdanik, L; Cady, J; Carmona, S; Daughrity, L; Dickson, DW; Gendron, TF; Grant, S; Harms, MB; Ho, R; Kim, KJ; Lall, D; Lee, EB; Liu, EY; Lutz, CM; Muhammad, AKMG; O'Rourke, JG; Petrucelli, L; Simpkinson, M; Wu, K; Zarrow, J | 1 |
| Barhum, Y; Ben-Zur, T; Benkler, C; Offen, D | 1 |
| Abe, T; Harada, M; Izumi, Y; Kaji, R; Sako, W | 1 |
| Kiviharju, A; Laaksovirta, H; Lindholm, D; Tienari, P; Valori, M | 1 |
| Chang, Q; Martin, LJ | 1 |
| Corsini, S; Nistri, A; Tortora, M | 1 |
| Bachurin, SO; Efimova, AD; Grigoriev, VV; Myasoedov, NF; Shevchenko, VP; Ustyugov, AA | 1 |
| Bonanno, G; Bonifacino, T; Cattaneo, L; Gallia, E; Marte, A; Milanese, M; Musazzi, L; Onofri, F; Popoli, M; Seguini, M | 1 |
| Bramanti, P; Cocco, L; Diomede, F; Grassi, G; Mazzon, E; Piattelli, A; Pollastro, F; Rajan, TS; Scionti, D; Trubiani, O | 1 |
| Oliveira, AS; Pinto, WB; Rezende, FM; Souza, PV | 1 |
| Kamishina, H; Kato, S; Kobatake, Y; Kohyama, M; Maeda, S; Sakai, H; Sasaki, J; Tsukui, T; Urushitani, M; Yamato, O | 1 |
| Bendotti, C; Cantoni, L; Keun, HC; Tortarolo, M; Valbuena, GN | 1 |
| Clatterbuck-Soper, SF; Jackrel, ME; Mili, S; Shorter, J; Yasuda, K | 1 |
| Banner, S; Davies, J; Leigh, PN; Manser, C; McLoughlin, DM; Miller, CCJ; Ono, Y; Shaw, CE; Stevenson, A; Tudor, EL | 1 |
| Bogush, A; Boston-Howes, W; Pasinelli, P; Scolere, M; Trotti, D; Williams, EO | 1 |
| Beart, PM; Nagley, P; O'Shea, RD; Wallis, N; Zagami, CJ | 1 |
| Bordoni, A; Bresolin, N; Comi, GP; Corti, S; Crugnola, V; Del Bo, R; Donadoni, C; Fortunato, F; Lucchini, V; Moggio, M; Papadimitriou, D; Ronchi, D; Salani, S; Santoro, D | 1 |
| Maragakis, NJ | 1 |
| Kiernan, MC; Vucic, S | 1 |
| Kiernan, MC | 1 |
| Liu, X; Lobner, D; Rush, T; Zapata, J | 1 |
| Ishige, K; Ito, Y; Kosuge, Y; Negi, H; Sekikawa-Nishida, K | 1 |
| Bernardi, G; Carrì, MT; Centonze, D; Cozzolino, M; De Chiara, V; Maccarrone, M; Mercuri, NB; Musella, A; Rossi, S | 1 |
| Bonanno, G; Bonifacino, T; Milanese, M; Nobile, M; Tacchetti, C; Usai, C; Zappettini, S | 1 |
| Gozen, O; Robinson, MB; Rothstein, JD; Vidensky, S; Yang, Y | 1 |
| Lacomblez, L; Meininger, V; Salachas, F | 2 |
| Cheah, BC; Kiernan, MC; Vucic, S | 1 |
| Fiszman, ML; Latini, A; Ricart, KC; Rodríguez, G; Sica, RE | 1 |
| Durand, J; Gueritaud, JP; Pambo-Pambo, A | 1 |
| Choi, JK; Dedeoglu, A; Jenkins, BG; Küstermann, E | 1 |
| Cleveland, DW; Ilieva, H; Polymenidou, M | 1 |
| Bame, M; Brusilow, WS; Galloway, MP; Ghoddoussi, F; Jambekar, A; Needleman, R | 1 |
| Babu, GN; Bala, L; Kalita, J; Khetrapal, CL; Kumar, A; Misra, UK; Singh, RL | 1 |
| Bonanno, G; Bonifacino, T; Cervetto, C; Jacchetti, E; Milanese, M; Usai, C; Zappettini, S | 1 |
| Chen, F; Geng, J; Gu, R; Hou, X; Li, L; Pang, R; Xu, Y; Zhang, C | 1 |
| Aiso, S; Sasabe, J | 1 |
| Atassi, N; Bombardier, J; Cudkowicz, M; Dibernardo, A; Eckenrode, J; Greenblatt, DJ; Pulley, D; Ratai, EM; Wallace, S; Zhao, Y | 1 |
| Beghi, E; Chiò, A; Couratier, P; Esteban, J; Hardiman, O; Logroscino, G; Millul, A; Mitchell, D; Preux, PM; Pupillo, E; Stevic, Z; Swingler, R; Traynor, BJ; Van den Berg, LH; Veldink, JH; Zoccolella, S | 1 |
| Argyriou, AA; Giannakopoulou, F; Karanasios, P; Makridou, A; Makris, N; Vlachou, M | 1 |
| Caraballo-Miralles, V; Lladó, J; Olmos, G; Tolosa, L | 1 |
| Benfenati, F; Bonanno, G; Bonifacino, T; Messa, M; Milanese, M; Musazzi, L; Onofri, F; Popoli, M; Racagni, G; Tardito, D; Usai, C; Zappettini, S | 1 |
| Cifra, A; Nani, F; Nistri, A | 1 |
| Calamandrei, G; Ferrante, A; Martire, A; Pieri, M; Popoli, P; Rungi, A; Venerosi, A; Zona, C | 1 |
| Fan, DS; Zheng, M | 1 |
| Calcagno, E; Cantoni, L; D'Alessandro, G; Invernizzi, RW; Rizzardini, M; Tartari, S | 1 |
| Atchison, WD; Chitrakar, A; Hajela, RK; Johnson, FO; Parsell, DM; Yuan, Y | 1 |
| Antonini, A; Caioli, S; Curcio, L; Marolda, R; Pieri, M; Severini, C; Zona, C | 1 |
| Casanovas, A; Esquerda, J; Hernández, S; Marsal, J; Martín-Satué, M; Povedano, M; Solsona, C; Texidó, L | 1 |
| Al-Mohanna, F; Al-Saif, A; Bohlega, S | 1 |
| Cashman, NR; Lu, J; Mackenzie, IR; Taghibiglou, C; Wang, YT | 1 |
| Bettini, M; González Deniselle, MC; Monachelli, GM; Nicola, AF; Peralta, LM; Rodriguez, G; Sica, RE | 1 |
| Barber, S; Ferraiuolo, L; Greenald, D; Heath, PR; Higginbottom, A; Kirby, J; Shaw, PJ | 1 |
| Fujita, Y; Ikeda, M; Okamoto, K; Senoo, Y; Yanagisawa, T | 1 |
| Galán, L; García, AG; Guerrero, A; Matías-Guiu, J; Vela, A; Yáñez, M | 1 |
| Quinlan, KA | 1 |
| Cifra, A; Mazzone, GL; Nistri, A | 1 |
| Anna Rossi, PI; Bonanno, G; Bonifacino, T; Di Prisco, S; Giribaldi, F; Milanese, M; Pittaluga, A; Puliti, A; Tacchetti, C; Usai, C | 1 |
| Eisen, A; Hallett, M; Kiernan, MC; Vucic, S; Ziemann, U | 1 |
| Abe, K; Manabe, Y; Murakami, T | 1 |
| Heath, PR; Shaw, PJ | 1 |
| Heath, PR; Ince, PG; Shaw, PJ; Tomkins, J | 1 |
| Butchbach, ME; Guo, H; Lai, L; Lin, CL | 1 |
| Beal McIlvain, H; Dunlop, J; Howland, DS; She, Y | 1 |
| Angelov, DN; Guntinas-Lichius, O; Kipnis, J; Lenzen, M; Ludolph, A; Neiss, WF; Reuter, A; Schori, H; Schwartz, M; Tomov, TL; Waibel, S; Yoles, E | 1 |
| Bonanno, G; Paolucci, E; Prisco, S; Raiteri, L; Raiteri, M | 1 |
| Rao, SD; Weiss, JH; Yin, HZ | 1 |
| Aizawa, H; Hashida, H; Ito, K; Jeong, SY; Kanazawa, I; Kawahara, Y; Kwak, S; Sun, H | 1 |
| Craig, UK; Khabazian, I; Pow, DV; Shaw, CA; Wilson, JM | 1 |
| Shigeri, Y; Shimamoto, K | 1 |
| Ikeda, K; Iwasaki, Y; Kinoshita, M | 1 |
| Askmark, H; Persson, LI; Ryberg, H | 1 |
| Batulan, Z; Doroudchi, MM; Durham, HD; He, BP; Minotti, S; Nalbantoglu, J; Shinder, GA; Strong, MJ | 1 |
| Citron, BA; Festoff, BW; Suo, Z | 1 |
| Bodner, A; Canto, MD; Ghadge, GD; Majer, P; Miller, RJ; Monti, AL; Rojas, C; Roos, RP; Slusher, BS; Thomas, AG; Tsukamoto, T; Wozniak, K | 1 |
| Bishop, GA; Butchbach, ME; Guo, H; Lai, L; Lin, CL; Shan, X; Stockinger, MP | 1 |
| Vanacore, N | 1 |
| Cheema, SS; McQuilty, R; Pamphlett, R; Todd, E; Vink, R | 1 |
| Brown, RH; Camelo, S; Dangond, F; Frosch, MP; Gullans, SR; Hwang, D; Pasinelli, P; Stephanopoulos, G | 1 |
| Rao, SD; Weiss, JH | 1 |
| Fukada, K; Hirata, S; Nagano, S; Nakanishi, T; Okuno, T; Sakoda, S; Sato, T; Shimizu, A; Sugai, F; Yamamoto, Y; Zhou, Z | 1 |
| Bonanno, G; Mercuri, NB; Raiteri, L; Raiteri, M; Stigliani, S; Zappettini, S | 1 |
| Bruneteau, G; Demeret, S; Meininger, V | 1 |
| Anneser, JM; Borasio, GD; Ince, PG; Shaw, PJ | 1 |
| Bruijn, LI; Cleveland, DW; Miller, TM | 1 |
| Appel, SH; Beers, DR; He, Y; Henkel, JS; Le, W; Simpson, EP; Xiao, Q; Xie, W; Yen, AA; Zhao, W | 1 |
| Carrega, P; Conforti, L; Losa, M; Massari, S; Perego, C; Pietrini, G; Vanoni, C | 1 |
| Appel, SH; Berg, JE; Bradley, WG; Brooks, BR; Olney, RK; Pope, LE; Smith, RA; Thisted, RA | 1 |
| Albo, F; Bernardi, G; Ferrari, F; Longone, P; Pascucci, T; Puglisi-Allegra, S; Spalloni, A; Zona, C | 1 |
| Barbeito, LH; Beckman, JS; Cassina, P; Estévez, AG; Pehar, M; Peluffo, H; Vargas, MR; Viera, L | 1 |
| Cleveland, DW; Miller, TM | 1 |
| Beretta, S; Carrì, MT; Ceresa, C; Ferrarese, C; Ferri, A; Mattavelli, L; Sala, G; Tremolizzo, L; Zoia, C | 1 |
| Brown, RH | 1 |
| Horiuchi, S; Kawaguchi, M; Kobayashi, M; Shibata, N | 1 |
| Hinoi, E; Takarada, T; Tsuchihashi, Y; Yoneda, Y | 1 |
| Beghi, E; Bendotti, C; Mennini, T | 1 |
| Bonanno, G; Paluzzi, S; Raiteri, L; Raiteri, M; Stigliani, S; Zappettini, S | 1 |
| Calderó, J; Casas, C; Esquerda, JE; Oppenheim, RW; Tarabal, O | 1 |
| Backus, C; Feldman, EL; Taubman, AA; Vincent, AM | 1 |
| Annesi, F; Annesi, G; Arabia, G; Caracciolo, M; Cirò Candiano, IC; Civitelli, D; D'Amelio, M; Fierro, B; La Bella, V; Piccoli, F; Piccoli, T; Pugliese, P; Quattrone, A; Ragonese, P; Savettieri, G; Tarantino, P | 1 |
| Tapia, R; Tovar-y-Romo, LB | 1 |
| Hemptinne, I; Hermans, E; Maloteaux, JM; Tilleux, S; Vanhoutte, N; Vermeiren, C | 1 |
| Boston-Howes, W; Brown, RH; Gibb, SL; Pasinelli, P; Trotti, D; Williams, EO | 1 |
| Conforti, FL; Gabriele, A; Labella, V; Magariello, A; Majorana, G; Mazzei, R; Monsurrò, MR; Muglia, M; Patitucci, A; Quattrone, A; Simone, IL; Sprovieri, T; Tedeschi, G; Tessitore, A; Ungaro, C; Valentino, P | 1 |
| Anneser, JM; Borasio, GD; Chahli, C | 1 |
| Boulis, NM; Federici, T; Garrity-Moses, ME; Krudy, C; Teng, Q; Yang, J | 1 |
| Sandyk, R | 1 |
| Dewil, M; Robberecht, W; Van Damme, P; Van Den Bosch, L | 1 |
| Bufler, J; Dengler, R; Grosskreutz, J; Grothe, C; Haastert, K; Jahn, K; Schlesinger, F; Ziegler, E | 1 |
| Bach, A; Bähr, M; Bartels, C; Bohn, M; Dietrich, J; Ehrenreich, H; Hardeland, R; Hüther, G; Mertens, N; Nave, KA; Poeggeler, B; Pölking, E; Rohde, G; Schneider, A; Sirén, AL; Sperling, S; Weishaupt, JH | 1 |
| Gebarowska, J; Matyja, E; Nagańska, E; Rafałowska, J; Taraszewska, A | 1 |
| Cintas, P | 1 |
| Alexander, GM; Perreault, MJ; Reichenberger, ER; Schwartzman, RJ | 1 |
| Alladi, PA; Nalini, A; Raju, TR; Sathyaprabha, TN; Shobha, K; Vijayalakshmi, K | 1 |
| Holden, C | 1 |
| Lee, NM; Smith, AP | 1 |
| Albers, W; Amin, N; Bjelogrlic, M; Grant, P; Gutkind, JS; Jaffe, H; Kesavapany, S; Pant, HC; Pareek, TK; Patel, V; Strong, MJ; Zheng, YL | 1 |
| Bernardi, G; Centonze, D; Finazzi-Agrò, A; Maccarrone, M; Rossi, S | 1 |
| Aiso, S; Chiba, T; Matsuoka, M; Nishimoto, I; Okamoto, K; Sasabe, J; Yamada, M | 1 |
| Izumi, Y; Kaji, R | 1 |
| Corona, JC; Tapia, R; Tovar-y-Romo, LB | 1 |
| Andreadou, E; Kapaki, E; Katsaros, N; Kokotis, P; Libitaki, G; Paraskevas, GP; Sfagos, C; Vassilopoulos, D; Zis, V | 1 |
| Abood, ME; Beattie, EC; Ignacio, S; Zhao, P | 1 |
| Appel, SH; Smith, RG | 1 |
| Broom, JK; Domigan, NM; Winterbourn, CC | 1 |
| el-Shamy, W; Eriksson, C; Eriksson, G; Holme, E; Larsson, NG; Peterson, A; Walum, E | 1 |
| Gredal, O; Møller, SE | 1 |
| Eisen, A | 1 |
| Floridi, S; Racagni, G; Trotti, D; Volterra, A | 1 |
| Beckman, JS; Chen, J; Crow, JP; Ye, YZ | 1 |
| Fujita, K; Honda, M; Nagata, Y | 1 |
| Cameron, D; Eisen, A; Schulzer, M; Stewart, H | 1 |
| Bristol, LA; Brown, RH; Hosler, B; Kuncl, RW; Rothstein, JD | 1 |
| Araki, H; Fujii, J; Hirano, M; Nagai, Y; Okamoto, K; Sonobe, M; Taniguchi, N; Ueno, S | 1 |
| Eisen, A; Pant, B; Stewart, H | 1 |
| Kaji, R; Kimura, J | 1 |
| Bastone, A; Beghi, E; Micheli, A; Salmona, M | 1 |
| Munsat, TL; Serratrice, GT | 1 |
| Eisen, AA | 1 |
| Miscio, G; Pinelli, P; Pisano, F | 1 |
| Rothstein, JD | 2 |
| Hugon, J | 1 |
| Jones, AP; Knight, JM; Redmond, JP; Shaw, IC | 1 |
| Vogel, G | 1 |
| Zeitlhofer, J | 1 |
| Moriwaka, F | 1 |
| Appel, SH; Goodman, JC; La Bella, V | 1 |
| Ince, PG; Shaw, PJ | 1 |
| Andjus, PR; Cherubini, E; Stevic-Marinkovic, Z | 1 |
| Maruri, A; Olivera, S; Rodríguez-Ithurralde, D; Vincent, O | 1 |
| Obrenovitch, TP | 1 |
| Bristol, LA; Clawson, L; Crawford, T; Dykes-Hoberg, M; Jin, L; Lin, CL; Rothstein, JD | 1 |
| Boireau, A; Canton, T; Imperato, A; Pratt, J; Stutzmann, JM | 1 |
| Ince, PG; Lowe, J; Shaw, PJ | 1 |
| Babu, GN; Bawari, M; Kalita, J; Mathur, VN; Misra, UK | 1 |
| Akaike, A; Ibi, M; Inoue, R; Kihara, T; Kimura, J; Kitamura, Y; Sawada, H; Shimohama, S; Taniguchi, T; Urushitani, M | 1 |
| Bolaños, JP; Brookes, PS; Clark, JB; Heales, SJ; Land, JM; Stewart, VC | 1 |
| Miller, RG | 1 |
| Doble, A | 1 |
| Majors, AW; Mitsumoto, H; Nelson, DR; Ng, TC; Pioro, EP | 1 |
| Abe, K; Manabe, Y | 1 |
| Asahara, H; Kira, J; Ohyagi, Y; Taniwaki, T; Yamada, T | 1 |
| Guo, Z; Kindy, MS; Kruman, I; Mattson, MP | 1 |
| Alexander, GM; Deitch, JS; Del Valle, L; Heiman-Patterson, TD; Seeburger, JL | 1 |
| Ludolph, AC; Meyer, T; Riepe, MW | 1 |
| Braga, M; Cardin, V; Ciammola, A; Scarlato, G; Silani, V | 1 |
| Eggett, CJ; Shaw, PJ | 1 |
| Aĭrapetian, KV; Barkhatova, VP; Nikitin, SS; Zavalishin, IA | 1 |
| Aoki, M; Berger, UV; Brown, RH; Danbolt, NC; Hediger, MA; Pasinelli, P; Trotti, D | 1 |
| Balzarini, C; Bastone, A; Beghi, E; Begni, B; Ferrarese, C; Frattola, L; Galimberti, G; Mennini, T; Millul, A; Riva, R; Sala, G; Tremolizzo, L; Zoia, C | 1 |
| Doroudchi, MM; Durham, HD; Figlewicz, DA; Minotti, S | 1 |
| Anneser, J | 1 |
| Abe, K; Iwata, M; Komori, T; Sasaki, S; Warita, H | 1 |
| Alavijeh, M; Böhme, GA; Boireau, A; Bordier, F; Brealey, C; Briet, D; Canton, T; Debono, MW; Jahn, G; Jimonet, P; Laville, M; Le Guern, S; Mignani, S; Pratt, J; Roberts, S; Roux, M; Stutzmann, JM; Stygall, J; Vuilhorgne, M | 1 |
| Brorson, JR; Vandenberghe, W | 1 |
| Bufler, J; Dengler, R; Krampfl, K; Schlesinger, F; Wolfes, H | 1 |
| Capobianco, A; Comoletti, D; Mennini, T; Muzio, V; Ravizza, T | 1 |
| Bastone, A; Bendotti, C; Calvaresi, N; Carvelli, L; Mennini, T; Rattray, M; Rizzi, M; Suchak, SK; Tortarolo, M | 1 |
| Cluskey, S; Ramsden, DB | 1 |
| Braga, M; Cardin, V; Scarlato, G; Silani, V | 1 |
| Bär, PR; Cools, AR; Gribnau, AA; Joosten, EA; Van Westerlaak, MG | 1 |
| Bensimon, G; Dib, M; Lacomblez, L; Le Forestier, N; Marouan, A; Meininger, V; Pradat, PF; Salachas, F; Spreux-Varoquaux, O | 1 |
| Alexander, GM; Deitch, JS; Del Valle, L; Heiman-Patterson, TD | 1 |
| Hand, CK; Rouleau, GA | 1 |
| Adalbert, R; Engelhardt, JI; Siklós, L | 1 |
| Emeryk-Szajewska, B; Karwańska, A; Kostera-Pruszczyk, A; Niebroj-Dobosz, I; Rowińska-Marcińska, K | 1 |
| Janik, P; Kwieciński, H; Niebroj-Dobosz, I | 1 |
| Choi, DW | 1 |
| Kuncl, RW; Martin, LJ; Rothstein, JD | 1 |
| Caraceni, T; Fetoni, V; Girotti, F; Testa, D | 1 |
| Ono, S; Yamauchi, M | 1 |
| Plaitakis, A | 2 |
| Chaudhry, V; Clawson, L; Cornblath, DR; Coyle, JT; Drachman, DB; Kuncl, R; Rothstein, JD | 1 |
| Coyle, JT; Hedreen, JC; Kuncl, R; Rothstein, JD; Sim, L; Stauch-Slusher, B; Tsai, GC | 1 |
| Cottell, E; Harrington, MG; Hutchinson, M; Simon, J | 1 |
| Hansen, S; Jones, K; Perry, TL | 1 |
| Caroscio, JT; Plaitakis, A | 1 |
| Constantakakis, E; Plaitakis, A; Smith, J | 1 |
72 review(s) available for glutamic acid and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
The Serotonergic System and Amyotrophic Lateral Sclerosis: A Review of Current Evidence.
Topics: Amyotrophic Lateral Sclerosis; Animals; Glutamic Acid; Motor Neurons; Neurotransmitter Agents; Serotonin | 2023 |
A Medicinal Chemistry Perspective on Excitatory Amino Acid Transporter 2 Dysfunction in Neurodegenerative Diseases.
Topics: Amyotrophic Lateral Sclerosis; Animals; Brain; Chemistry, Pharmaceutical; Excitatory Amino Acid Transporter 2; Glutamic Acid; Humans; Mammals; Neurodegenerative Diseases | 2023 |
Impact of Plant-Derived Compounds on Amyotrophic Lateral Sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Edaravone; Glutamic Acid; Humans; Phytochemicals; Riluzole | 2023 |
Glial Glutamate Transporter-Mediated Plasticity: System x
Topics: Alzheimer Disease; Amino Acid Transport System X-AG; Amino Acid Transport System y+; Amyotrophic Lateral Sclerosis; Antioxidants; Cystine; Glioma; Glutamic Acid; Humans; Microglia; Multiple Sclerosis; Parkinson Disease | 2023 |
The Key Role of Astrocytes in Amyotrophic Lateral Sclerosis and Their Commitment to Glutamate Excitotoxicity.
Topics: Amyotrophic Lateral Sclerosis; Astrocytes; Glutamic Acid; Humans; Neuroglia; Neurons | 2023 |
Multiple Roles of Transforming Growth Factor Beta in Amyotrophic Lateral Sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Gene Expression Regulation; Glutamic Acid; Humans; Motor Neurons; Muscle Fibers, Skeletal; Neuroglia; Signal Transduction; Transforming Growth Factor beta | 2020 |
Evaluating a Gene-Environment Interaction in Amyotrophic Lateral Sclerosis: Methylmercury Exposure and Mutated SOD1.
Topics: Amyotrophic Lateral Sclerosis; Calcium; Free Radical Scavengers; Gene-Environment Interaction; Glutamic Acid; Humans; Methylmercury Compounds; Receptors, AMPA; Superoxide Dismutase | 2017 |
Astrocytes Pathology in ALS: A Potential Therapeutic Target?
Topics: Amyotrophic Lateral Sclerosis; Animals; Astrocytes; Drug Delivery Systems; Glutamic Acid; Humans; Motor Neurons; Neuroprotective Agents; Oxidative Stress | 2017 |
EAAT2 and the Molecular Signature of Amyotrophic Lateral Sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Excitatory Amino Acid Transporter 2; Excitatory Amino Acids; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Humans | 2017 |
Fungal Neurotoxins and Sporadic Amyotrophic Lateral Sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Brain; DNA-Binding Proteins; Glutamic Acid; Humans; Motor Neurons; Mycoses; Mycotoxins; Neurotoxins; Superoxide Dismutase-1 | 2019 |
Redox regulation in amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Autophagy; Axonal Transport; Cholesterol; Endoplasmic Reticulum Stress; Glutamic Acid; Humans; Lipid Peroxidation; Mitochondria; Oxidation-Reduction; Oxidative Stress; Protein Disulfide-Isomerases | 2013 |
Sumoylation of critical proteins in amyotrophic lateral sclerosis: emerging pathways of pathogenesis.
Topics: Amino Acid Sequence; Amyotrophic Lateral Sclerosis; Animals; Astrocytes; Calcium Signaling; Disease Models, Animal; DNA-Binding Proteins; Excitatory Amino Acid Transporter 2; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Humans; Models, Molecular; Molecular Sequence Data; Motor Neurons; Muscular Disorders, Atrophic; Nerve Tissue Proteins; Protein Conformation; RNA-Binding Protein FUS; Small Ubiquitin-Related Modifier Proteins; Sumoylation; Superoxide Dismutase; Superoxide Dismutase-1 | 2013 |
Moving forward in clinical trials for ALS: motor neurons lead the way please.
Topics: Amyotrophic Lateral Sclerosis; Animals; Clinical Trials as Topic; Glutamic Acid; Humans; Mitochondria; Motor Neurons; Nerve Growth Factors | 2014 |
D-Serine in neurobiology: CNS neurotransmission and neuromodulation.
Topics: Alzheimer Disease; Amyotrophic Lateral Sclerosis; Animals; Central Nervous System; Epilepsy; Glutamic Acid; Humans; Hypoxia-Ischemia, Brain; Mental Disorders; Neurodegenerative Diseases; Neuronal Plasticity; Neurotransmitter Agents; Receptors, N-Methyl-D-Aspartate; Serine; Synaptic Transmission | 2014 |
Motor neuron disease: a chemical perspective.
Topics: Amino Acid Transport System X-AG; Amyotrophic Lateral Sclerosis; Animals; Antioxidants; Apoptosis; Disease Models, Animal; Genetic Therapy; Glutamic Acid; Humans; Mice, Transgenic; Mitochondria; Mutation; Neuroprotective Agents; Reactive Oxygen Species; Receptors, Glutamate; Superoxide Dismutase; Superoxide Dismutase-1 | 2014 |
Biomarkers and future targets for development in amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Biomarkers; Disease Models, Animal; DNA-Binding Proteins; Glutamic Acid; Humans; Neuroprotective Agents; Oligonucleotides, Antisense; Receptors, AMPA; Sodium Channels; Superoxide Dismutase; Superoxide Dismutase-1 | 2014 |
The glutamate hypothesis in ALS: pathophysiology and drug development.
Topics: Amino Acid Transport System X-AG; Amyotrophic Lateral Sclerosis; Glutamic Acid; Humans; Motor Neurons; Neuroprotective Agents; Receptors, Glutamate; Riluzole | 2014 |
Excitotoxicity in ALS: Overstimulation, or overreaction?
Topics: Amyotrophic Lateral Sclerosis; Cell Death; Glutamic Acid; Humans; Motor Neurons; Nerve Degeneration; Spinal Cord | 2016 |
[The pathogenesis of amyotrophic lateral sclerosis and frontal lobe dementia is unraveling: pathology of the nucleus and glutamate sensitivity].
Topics: Amyotrophic Lateral Sclerosis; C9orf72 Protein; DNA Repeat Expansion; Frontotemporal Dementia; Glutamic Acid; Humans; Mutation; Proteins | 2016 |
Far beyond the motor neuron: the role of glial cells in amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Glutamic Acid; Humans; Medical Illustration; Motor Neurons; Nerve Growth Factors; Neuroglia | 2016 |
Pathophysiology of neurodegeneration in familial amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Ciliary Neurotrophic Factor; Glutamic Acid; Humans; Intermediate Filament Proteins; Membrane Glycoproteins; Mitochondria; Motor Neurons; Mutation; Nerve Degeneration; Nerve Tissue Proteins; Neurofilament Proteins; Peripherins; Ribonuclease, Pancreatic; Sodium-Potassium-Exchanging ATPase; Superoxide Dismutase; Superoxide Dismutase-1; Survival of Motor Neuron 1 Protein; Vascular Endothelial Growth Factor A | 2009 |
Glutamate release from astrocytic gliosomes under physiological and pathological conditions.
Topics: Amyotrophic Lateral Sclerosis; Animals; Astrocytes; Brain; Exocytosis; Glutamic Acid; Spinal Cord; Subcellular Fractions; Symporters | 2009 |
What has changed with riluzole?
Topics: Amyotrophic Lateral Sclerosis; Animals; Glutamic Acid; Humans; Neuroprotective Agents; Research; Riluzole; Treatment Outcome | 2000 |
Non-cell autonomous toxicity in neurodegenerative disorders: ALS and beyond.
Topics: Amyotrophic Lateral Sclerosis; Animals; Astrocytes; Axonal Transport; Capillaries; Cell Death; Endoplasmic Reticulum; Glutamic Acid; Humans; Microglia; Mutation; Nerve Degeneration; Neurons; Stress, Physiological; Superoxide Dismutase; Superoxide Dismutase-1; Superoxides; T-Lymphocytes | 2009 |
Aberrant control of motoneuronal excitability in amyotrophic lateral sclerosis: excitatory glutamate/D-serine vs. inhibitory glycine/gamma-aminobutanoic acid (GABA).
Topics: Amyotrophic Lateral Sclerosis; Excitatory Amino Acids; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Motor Neurons; Neurotransmitter Agents; Receptors, Glutamate; Serine | 2010 |
The epidemiology and treatment of ALS: focus on the heterogeneity of the disease and critical appraisal of therapeutic trials.
Topics: Aged; Amyotrophic Lateral Sclerosis; Antioxidants; Clinical Trials as Topic; Enteral Nutrition; Europe; Glutamic Acid; Humans; Incidence; Intercellular Signaling Peptides and Proteins; Middle Aged; Prognosis; Randomized Controlled Trials as Topic; Registries; Research Design; Respiration, Artificial; Riluzole; Treatment Outcome; United States; White People | 2011 |
Sporadic amyotrophic lateral sclerosis: new hypothesis regarding its etiology and pathogenesis suggests that astrocytes might be the primary target hosting a still unknown external agent.
Topics: Amyotrophic Lateral Sclerosis; Astrocytes; Cell Death; Glutamic Acid; Humans; Neurons; Neurotoxins; Nuclear Proteins; Oxidative Stress | 2011 |
Links between electrophysiological and molecular pathology of amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Astrocytes; Calcium; Calcium-Binding Proteins; Disease Models, Animal; Electrophysiological Phenomena; Endoplasmic Reticulum; Glutamic Acid; Membrane Potential, Mitochondrial; Mice; Motor Neurons; Neural Conduction; Proteolysis; Stress, Physiological; Superoxide Dismutase; Superoxide Dismutase-1 | 2011 |
Riluzole: what it does to spinal and brainstem neurons and how it does it.
Topics: Amyotrophic Lateral Sclerosis; Brain Stem; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Motor Neurons; Neuroprotective Agents; Riluzole; Spinal Cord | 2013 |
Transcranial magnetic stimulation and amyotrophic lateral sclerosis: pathophysiological insights.
Topics: Amyotrophic Lateral Sclerosis; Anterior Horn Cells; Brain Stem; Electromyography; Evoked Potentials, Motor; Glutamic Acid; Humans; Interneurons; Mitochondria, Muscle; Motor Cortex; Motor Neurons; Muscle, Skeletal; Nerve Net; Neural Inhibition; Pyramidal Tracts; Recruitment, Neurophysiological; Reference Values; Synaptic Transmission; Transcranial Magnetic Stimulation | 2013 |
Update on the glutamatergic neurotransmitter system and the role of excitotoxicity in amyotrophic lateral sclerosis.
Topics: Amino Acid Transport System X-AG; Amyotrophic Lateral Sclerosis; Animals; Excitatory Amino Acids; Glutamic Acid; Humans; Motor Neurons; Neural Pathways; Neurotransmitter Agents; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate | 2002 |
[Excitatory amino acid transporters: development of regulatory molecules for their functional analysis].
Topics: Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Drug Design; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Receptors, Glutamate | 2003 |
Molecular and cellular mechanism of glutamate receptors in relation to amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Binding Sites; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Receptors, Glutamate | 2002 |
Prospects for the pharmacotherapy of amyotrophic lateral sclerosis : old strategies and new paradigms for the third millennium.
Topics: Amyotrophic Lateral Sclerosis; Animals; Cell Death; Drug Design; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Neurons; Oxidative Stress; Reactive Oxygen Species; Riluzole | 2003 |
Excitotoxic and oxidative cross-talk between motor neurons and glia in ALS pathogenesis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Cell Communication; Glutamic Acid; Humans; Models, Neurological; Motor Neurons; Neuroglia; Reactive Oxygen Species; Spinal Cord | 2004 |
[Physiopathology of ALS: therapeutic approach].
Topics: Amyotrophic Lateral Sclerosis; Animals; Apoptosis; Axons; Calcium; Clinical Trials as Topic; Disease Models, Animal; Glutamic Acid; Growth Substances; Humans; Intermediate Filaments; Mitochondria, Muscle; Motor Neurons; Oxidative Stress; Superoxide Dismutase | 2004 |
Unraveling the mechanisms involved in motor neuron degeneration in ALS.
Topics: Amyotrophic Lateral Sclerosis; Animals; Dyneins; Glutamic Acid; Humans; Models, Neurological; Motor Neurons; Nerve Degeneration; Neurofilament Proteins; Superoxide Dismutase; Vascular Endothelial Growth Factor A | 2004 |
A role for astrocytes in motor neuron loss in amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Apoptosis; Astrocytes; Cell Communication; Gliosis; Glutamic Acid; Humans; Inflammation Mediators; Motor Neurons | 2004 |
Glutamate transporters as drug targets.
Topics: Alzheimer Disease; Amino Acid Transport System X-AG; Amyotrophic Lateral Sclerosis; Animals; Biological Transport; Brain Ischemia; Drug Design; Epilepsy; Glutamic Acid; Humans; Membrane Transport Proteins; Schizophrenia; Transport Vesicles | 2005 |
Serotonergic mechanisms in amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Glutamic Acid; Humans; Motor Activity; Neurons; Serotonin; Sleep, REM | 2006 |
Excitotoxicity and amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Calcium; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Motor Neurons; Nerve Degeneration; Receptors, Glutamate | 2005 |
Role of zinc in ALS.
Topics: Amyotrophic Lateral Sclerosis; Animals; Glutamic Acid; Humans; Mitochondria; Oxidative Stress; Zinc | 2007 |
The (endo)cannabinoid system in multiple sclerosis and amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Cannabinoid Receptor Modulators; Glutamic Acid; Humans; Microglia; Multiple Sclerosis; Neurodegenerative Diseases; Oxidative Stress; Synaptic Transmission | 2007 |
[Clinical trials of ultra-high-dose methylcobalamin in ALS].
Topics: Amyotrophic Lateral Sclerosis; Animals; Disease Progression; Double-Blind Method; Glutamic Acid; Humans; Pulse Therapy, Drug; Randomized Controlled Trials as Topic; Rats; Time Factors; Vitamin B 12 | 2007 |
Glutamate excitotoxicity and therapeutic targets for amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Calcium; Cell Death; Cytoplasm; Disease Models, Animal; Drug Delivery Systems; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Neurons; Receptors, AMPA | 2007 |
Molecular approaches to amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Autoimmune Diseases; Free Radicals; Glutamic Acid; Humans; Isoenzymes; Motor Neurons; Mutation; Nerve Degeneration; Phenotype; Superoxide Dismutase; Survival Rate | 1995 |
Use of primary cultures and continuous cell lines to study effects on astrocytic regulatory functions.
Topics: Amyotrophic Lateral Sclerosis; Animals; Astrocytes; Biological Transport, Active; Cell Line; Cells, Cultured; Energy Metabolism; Glutamic Acid; Metals; Oxygen Consumption; Rats; Solvents | 1995 |
Amyotrophic lateral sclerosis is a multifactorial disease.
Topics: Amyotrophic Lateral Sclerosis; Animals; Chromosome Mapping; Chromosomes, Human, Pair 21; Glutamic Acid; Humans; Mutation; Nerve Growth Factors; Neurofilament Proteins; Neurotoxins; Receptors, N-Methyl-D-Aspartate; Second Messenger Systems; Signal Transduction; Species Specificity; Superoxide Dismutase | 1995 |
Reactive oxygen species inhibit high-affinity glutamate uptake: molecular mechanism and neuropathological implications.
Topics: Amino Acid Transport System X-AG; Amyotrophic Lateral Sclerosis; Animals; Antioxidants; Astrocytes; Cerebral Cortex; Glutamic Acid; Glycoproteins; Humans; Hydrogen Peroxide; Ischemic Attack, Transient; Oxidation-Reduction; Rats; Reactive Oxygen Species; Xanthine; Xanthine Oxidase; Xanthines | 1994 |
Reactions of nitric oxide, superoxide and peroxynitrite with superoxide dismutase in neurodegeneration.
Topics: Amyotrophic Lateral Sclerosis; Animals; Brain Ischemia; Cattle; Glutamic Acid; Humans; Macrophages; Models, Neurological; Molecular Structure; Motor Neurons; Myocardial Ischemia; Nerve Degeneration; Nerve Tissue Proteins; Nitrates; Nitric Oxide; Peripheral Nerve Injuries; Peripheral Nerves; Superoxide Dismutase; Superoxides | 1994 |
Amyotrophic lateral sclerosis. A multifactorial disease.
Topics: Amyotrophic Lateral Sclerosis; Genetic Diseases, Inborn; Glutamic Acid; Humans; Nerve Growth Factors; Risk Factors; Second Messenger Systems | 1995 |
The possible role of a secondary pathogenetic factor in amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Autoimmunity; Electroencephalography; Glutamic Acid; Humans; Time Factors | 1995 |
Excitotoxic mechanisms in the pathogenesis of amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Glutamic Acid; Humans; Models, Biological; Neurotoxins; Neurotransmitter Agents; Receptors, Glutamate | 1995 |
Excitotoxicity hypothesis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Brain; Glutamic Acid; Humans; Motor Neurons; Neurotoxins | 1996 |
Riluzole and ALS therapy.
Topics: Amyotrophic Lateral Sclerosis; Double-Blind Method; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Motor Neurons; Neurologic Examination; Riluzole; Survival Analysis; Thiazoles | 1996 |
[Clinical aspects of amyotrophic lateral sclerosis].
Topics: Amyotrophic Lateral Sclerosis; Autoimmune Diseases; Bulbar Palsy, Progressive; Diagnosis, Differential; Glutamic Acid; Humans; Motor Neurons; Muscle Spasticity; Neurologic Examination; Reactive Oxygen Species | 1996 |
[Amyotrophic lateral sclerosis].
Topics: Adult; Amino Acids, Branched-Chain; Amyotrophic Lateral Sclerosis; Animals; Autoimmunity; Double-Blind Method; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Nerve Growth Factors; Nerve Tissue Proteins; Point Mutation; Randomized Controlled Trials as Topic; Riluzole; Superoxide Dismutase; Thiazoles; Threonine | 1997 |
Glutamate, excitotoxicity and amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Neuroprotective Agents; Receptors, Glutamate; Riluzole; Thiazoles | 1997 |
Amyotrophic lateral sclerosis: current issues in classification, pathogenesis and molecular pathology.
Topics: Amyotrophic Lateral Sclerosis; Animals; Diagnosis, Differential; Free Radicals; Glutamic Acid; Humans; Mice; Mice, Transgenic; Motor Neuron Disease; Ubiquitins | 1998 |
Nitric oxide, mitochondria and neurological disease.
Topics: Amyotrophic Lateral Sclerosis; Astrocytes; Cell Death; Electron Transport; Glutamic Acid; Humans; Mitochondria; Nervous System Diseases; Neurodegenerative Diseases; Neurons; Nitrates; Nitric Oxide; Permeability | 1999 |
Carrell-Krusen Symposium invited lecture. Clinical trials in motor neuron diseases.
Topics: Acetates; Adolescent; Adult; Amines; Amyotrophic Lateral Sclerosis; Animals; Brain-Derived Neurotrophic Factor; Child; Child, Preschool; Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Excitatory Amino Acid Antagonists; Female; Gabapentin; gamma-Aminobutyric Acid; Glutamic Acid; Guidelines as Topic; Humans; Infant; Insulin-Like Growth Factor I; Male; Mice; Middle Aged; Motor Neuron Disease; Muscular Atrophy, Spinal; Nerve Growth Factors; Outcome Assessment, Health Care; Postpoliomyelitis Syndrome; Riluzole | 1999 |
The role of excitotoxicity in neurodegenerative disease: implications for therapy.
Topics: AIDS Dementia Complex; Amyotrophic Lateral Sclerosis; Calcium; Excitatory Amino Acids; Glutamic Acid; Humans; N-Methylaspartate; Neurodegenerative Diseases; Neurotransmitter Agents | 1999 |
[Sporadic ALS].
Topics: Amino Acid Transport System X-AG; Amyotrophic Lateral Sclerosis; ATP-Binding Cassette Transporters; Diagnosis, Differential; Glutamic Acid; Humans; Motor Neurons; Prognosis | 1999 |
The role of excitotoxicity in ALS--what is the evidence?
Topics: Amyotrophic Lateral Sclerosis; Animals; Disease Models, Animal; Glutamic Acid; Humans; Hypoxia; Motor Neurons; Nerve Degeneration; Neurotoxins; Superoxide Dismutase; Superoxide Dismutase-1 | 2000 |
Motor neurones in culture as a model to study ALS.
Topics: Amyotrophic Lateral Sclerosis; Animals; Astrocytes; Calcium; Cell Survival; Culture Techniques; Disease Models, Animal; Glutamic Acid; Humans; Mitochondria; Motor Neurons; Point Mutation; Rats; Superoxide Dismutase; Superoxide Dismutase-1 | 2000 |
Molecular factors underlying selective vulnerability of motor neurons to neurodegeneration in amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Calcium-Binding Proteins; Cytoskeleton; Glutamic Acid; Humans; Mitochondria; Motor Neurons; Nerve Degeneration; Point Mutation; Receptors, Glutamate; Superoxide Dismutase; Superoxide Dismutase-1 | 2000 |
What has changed with riluzole?
Topics: Aged; Amyotrophic Lateral Sclerosis; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Humans; Male; Middle Aged; Neuroprotective Agents; Riluzole | 2000 |
Molecular basis of treatment in motor neurone disease.
Topics: Amyotrophic Lateral Sclerosis; Animals; Central Nervous System Viral Diseases; Glutamic Acid; Humans; Nerve Growth Factors; Neurofilament Proteins; Oxidative Stress; Receptors, Glutamate; Superoxide Dismutase; Superoxide Dismutase-1 | 2000 |
Mechanisms of neurodegeneration in amyotrophic lateral sclerosis.
Topics: Aged; Amyotrophic Lateral Sclerosis; Animals; Copper; Cytoplasm; Glutamic Acid; Humans; Mice; Mice, Transgenic; Middle Aged; Mitochondria; Models, Animal; Mutation; Nerve Degeneration; Neurofilament Proteins; Neurons; Oxidative Stress; Superoxide Dismutase; Superoxide Dismutase-1 | 2001 |
The pathogenesis of ALS: implications for treatment strategies.
Topics: Amyotrophic Lateral Sclerosis; Clinical Trials as Topic; Glutamic Acid; Humans; Neurotoxins | 2001 |
Familial amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Apoptosis; Copper; Genetic Linkage; Glutamic Acid; Humans; Mutation; Neurofilament Proteins; Oxidative Stress; Superoxide Dismutase; Superoxide Dismutase-1 | 2002 |
Altered glutamatergic mechanisms and selective motor neuron degeneration in amyotrophic lateral sclerosis: possible role of glycine.
Topics: Amyotrophic Lateral Sclerosis; Animals; Glutamates; Glutamic Acid; Glutamine; Glycine; Humans; Motor Neurons; Nerve Degeneration; Synaptic Transmission | 1991 |
11 trial(s) available for glutamic acid and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
A phase I, pharmacokinetic, dosage escalation study of creatine monohydrate in subjects with amyotrophic lateral sclerosis.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Brain; Creatine; Dose-Response Relationship, Drug; Female; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neuroprotective Agents | 2010 |
CSF from amyotrophic lateral sclerosis patients produces glutamate independent death of rat motor brain cortical neurons: protection by resveratrol but not riluzole.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Animals; Calcium; Cell Death; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Double-Blind Method; Drug Interactions; Embryo, Mammalian; Female; Glutamic Acid; Humans; L-Lactate Dehydrogenase; Male; Middle Aged; Motor Neurons; Neuroprotective Agents; Pregnancy; Rats; Resveratrol; Riluzole; Stilbenes | 2011 |
A double-blind randomized clinical trial in amyotrophic lateral sclerosis using lamotrigine: effects on CSF glutamate, aspartate, branched-chain amino acid levels and clinical parameters.
Topics: Adult; Aged; Amino Acids, Branched-Chain; Amyotrophic Lateral Sclerosis; Aspartic Acid; Cross-Over Studies; Double-Blind Method; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Humans; Lamotrigine; Male; Middle Aged; Outcome Assessment, Health Care; Triazines | 2003 |
Treatment of pseudobulbar affect in ALS with dextromethorphan/quinidine: a randomized trial.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Dextromethorphan; Double-Blind Method; Drug Combinations; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Humans; Male; Metabolic Clearance Rate; Middle Aged; Pseudobulbar Palsy; Quinidine; Receptors, N-Methyl-D-Aspartate; Treatment Outcome | 2004 |
Reduced oxidative damage in ALS by high-dose enteral melatonin treatment.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Animals; Biomarkers; Cell Line; Cytoprotection; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Glutamic Acid; Humans; Male; Melatonin; Mice; Mice, Transgenic; Middle Aged; Neurons; Oxidative Stress; Reactive Oxygen Species; Superoxide Dismutase; Superoxide Dismutase-1; Survival Rate; Vitamin E | 2006 |
Anti-glutamate therapy in amyotrophic lateral sclerosis: a trial using lamotrigine.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Anticonvulsants; Brain; Double-Blind Method; Electrophysiology; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Humans; Lamotrigine; Magnetics; Male; Middle Aged; Physical Stimulation; Triazines | 1993 |
The imbalance of brain large-chain aminoacid availability in amyotrophic lateral sclerosis patients treated with high doses of branched-chain aminoacids.
Topics: Adult; Aged; Amino Acids; Amino Acids, Branched-Chain; Amyotrophic Lateral Sclerosis; Biological Availability; Biological Transport; Brain; Case-Control Studies; Dose-Response Relationship, Drug; Female; Glutamic Acid; Humans; Male; Mathematics; Middle Aged; Models, Biological; Placebos | 1995 |
Riluzole and ALS therapy.
Topics: Amyotrophic Lateral Sclerosis; Double-Blind Method; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Motor Neurons; Neurologic Examination; Riluzole; Survival Analysis; Thiazoles | 1996 |
Motor unit hyperexcitability in amyotrophic lateral sclerosis vs amino acids acting as neurotransmitters.
Topics: Adult; Aged; Amino Acids; Amyotrophic Lateral Sclerosis; Aspartic Acid; Chromatography, High Pressure Liquid; Electromyography; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Humans; Male; Middle Aged; Motor Neurons; Muscle, Skeletal; Neurotransmitter Agents; Reference Values | 2002 |
Effect of Riluzole on serum amino acids in patients with amyotrophic lateral sclerosis.
Topics: Adult; Aged; Amino Acids; Amyotrophic Lateral Sclerosis; Aspartic Acid; Chromatography, High Pressure Liquid; Female; Follow-Up Studies; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Humans; Male; Middle Aged; Neurotransmitter Agents; Reference Values; Riluzole; Time | 2002 |
Chronic treatment with L-threonine in amyotrophic lateral sclerosis: a pilot study.
Topics: Administration, Oral; Adult; Aged; Amyotrophic Lateral Sclerosis; Drug Administration Schedule; Female; Follow-Up Studies; Glutamates; Glutamic Acid; Glycine; Humans; Male; Middle Aged; Neurologic Examination; Receptors, N-Methyl-D-Aspartate; Threonine | 1992 |
178 other study(ies) available for glutamic acid and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
A beneficial role for elevated extracellular glutamate in Amyotrophic Lateral Sclerosis and cerebral ischemia.
Topics: Amyotrophic Lateral Sclerosis; Brain Ischemia; Glutamic Acid; Humans; Neurons; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate | 2021 |
Coactivation of GSK3β and IGF-1 Attenuates Amyotrophic Lateral Sclerosis Nerve Fiber Cytopathies in SOD1 Mutant Patient-Derived Motor Neurons.
Topics: Amyotrophic Lateral Sclerosis; Animals; Axons; Benzyl Alcohols; Calcium; Cell Differentiation; Glucosides; Glutamic Acid; Glycogen Synthase Kinase 3 beta; Humans; Induced Pluripotent Stem Cells; Insulin-Like Growth Factor I; MAP Kinase Signaling System; Mice, Transgenic; Motor Neurons; Mutation; Nerve Degeneration; Nerve Fibers; Neurites; Superoxide Dismutase-1; Survival Analysis | 2021 |
A Glutamate Scavenging Protocol Combined with Deanna Protocol in SOD1-G93A Mouse Model of ALS.
Topics: Amyotrophic Lateral Sclerosis; Animals; Disease Models, Animal; Glutamic Acid; Mice; Mice, Transgenic; Superoxide Dismutase; Superoxide Dismutase-1 | 2023 |
Genetic Downregulation of the Metabotropic Glutamate Receptor Type 5 Dampens the Reactive and Neurotoxic Phenotype of Adult ALS Astrocytes.
Topics: Amyotrophic Lateral Sclerosis; Animals; Astrocytes; Down-Regulation; Glutamic Acid; Mice; Mice, Transgenic; Neurodegenerative Diseases; Receptor, Metabotropic Glutamate 5; Superoxide Dismutase-1 | 2023 |
AMPKα1 Deficiency in Astrocytes from a Rat Model of ALS Is Associated with an Altered Metabolic Resilience.
Topics: Adenosine Triphosphate; AMP-Activated Protein Kinases; Amyotrophic Lateral Sclerosis; Animals; Astrocytes; Glutamic Acid; Motor Neurons; Rats; Superoxide Dismutase-1 | 2023 |
GM1 ganglioside exerts protective effects against glutamate-excitotoxicity via its oligosaccharide in wild-type and amyotrophic lateral sclerosis motor neurons.
Topics: Amyotrophic Lateral Sclerosis; G(M1) Ganglioside; Glutamic Acid; Humans; Motor Neurons; Neurodegenerative Diseases; Superoxide Dismutase | 2023 |
Short echo-time Magnetic Resonance Spectroscopy in ALS, simultaneous quantification of glutamate and GABA at 3 T.
Topics: Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Atrophy; Choline; Creatine; Disease Progression; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Glutathione; Gray Matter; Hand Strength; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Cortex; Occipital Lobe; Pilot Projects; Severity of Illness Index; Single-Blind Method | 2019 |
Human iPSC-derived astrocytes from ALS patients with mutated C9ORF72 show increased oxidative stress and neurotoxicity.
Topics: Amyotrophic Lateral Sclerosis; Animals; Astrocytes; Biomarkers; C9orf72 Protein; Cells, Cultured; Cellular Reprogramming; Cellular Senescence; Cerebral Cortex; Disease Models, Animal; Gene Expression Profiling; Glutamic Acid; Humans; Induced Pluripotent Stem Cells; Mice; Motor Neurons; Mutation; Oxidative Stress; Proteomics; Reactive Oxygen Species | 2019 |
Soluble iron accumulation induces microglial glutamate release in the spinal cord of sporadic amyotrophic lateral sclerosis.
Topics: Adult; Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Cadaver; Female; Glutamic Acid; Humans; Iron; Male; Microglia; Middle Aged; Spinal Cord | 2020 |
Motor Neuron Generation from iPSCs from Identical Twins Discordant for Amyotrophic Lateral Sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Autophagy; Cell Survival; Glutamic Acid; Humans; Induced Pluripotent Stem Cells; Male; Middle Aged; Motor Neurons; Protein Aggregates; Solubility; Twins, Monozygotic; Whole Genome Sequencing | 2020 |
Acute neurotoxicant exposure induces hyperexcitability in mouse lumbar spinal motor neurons.
Topics: Amyotrophic Lateral Sclerosis; Animals; Disease Models, Animal; Environmental Exposure; Excitatory Postsynaptic Potentials; Glutamic Acid; Inhibitory Postsynaptic Potentials; Methylmercury Compounds; Mice; Motor Neurons; Nerve Net; Spinal Cord; Synaptic Transmission | 2020 |
Astrocytes release glutamate via cystine/glutamate antiporter upregulated in response to increased oxidative stress related to sporadic amyotrophic lateral sclerosis.
Topics: Amino Acid Transport System y+; Amyotrophic Lateral Sclerosis; Animals; Astrocytes; Glutamic Acid; Humans; Mice; Oxidative Stress; Spinal Cord; Up-Regulation | 2020 |
Blocking glutamate mGlu
Topics: Amyotrophic Lateral Sclerosis; Animals; Disease Models, Animal; Disease Progression; Female; Glutamic Acid; Male; Mice; Mice, Transgenic; Receptor, Metabotropic Glutamate 5; Spinal Cord; Superoxide Dismutase; Superoxide Dismutase-1 | 2021 |
GLT1 gene delivery based on bone marrow-derived cells ameliorates motor function and survival in a mouse model of ALS.
Topics: Amyotrophic Lateral Sclerosis; Animals; Biomarkers; Bone Marrow Cells; Bone Marrow Transplantation; Cell Survival; Cytokines; Disease Models, Animal; Disease Progression; Excitatory Amino Acid Transporter 2; Gene Expression Regulation; Gene Transfer Techniques; Genetic Therapy; Gliosis; Glutamic Acid; Lentivirus; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Motor Activity; Motor Neurons; Muscular Atrophy; Nerve Degeneration; RNA, Messenger; Spinal Cord; Superoxide Dismutase-1; Survival Analysis | 2021 |
Mutation of the caspase-3 cleavage site in the astroglial glutamate transporter EAAT2 delays disease progression and extends lifespan in the SOD1-G93A mouse model of ALS.
Topics: Amyotrophic Lateral Sclerosis; Animals; Astrocytes; Caspase 3; Disease Models, Animal; Disease Progression; Excitatory Amino Acid Transporter 2; Glutamic Acid; Intranuclear Inclusion Bodies; Mice; Motor Neurons; Mutation; Superoxide Dismutase | 2017 |
Targeting glutamate transporter-1 in neurological diseases.
Topics: Alzheimer Disease; Amino Acid Transport System X-AG; Amyotrophic Lateral Sclerosis; Animals; Astrocytes; Disease Progression; Epilepsy; Excitatory Amino Acid Transporter 2; Gene Expression Regulation; Glutamate Plasma Membrane Transport Proteins; Glutamates; Glutamic Acid; Homeostasis; Humans; Mice; Models, Biological; Nervous System Diseases; Neurodegenerative Diseases | 2017 |
Ultra high-field (7tesla) magnetic resonance spectroscopy in Amyotrophic Lateral Sclerosis.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Female; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Cortex; Motor Neurons | 2017 |
Differential involvement of vesicular and glial glutamate transporters around spinal α-motoneurons in the pathogenesis of SOD1
Topics: Amyotrophic Lateral Sclerosis; Animals; Disease Models, Animal; Excitatory Amino Acid Transporter 2; Glutamic Acid; Homeostasis; Mice, Transgenic; Motor Neurons; Neuroglia; Presynaptic Terminals; Spinal Cord; Superoxide Dismutase; Vesicular Glutamate Transport Protein 2 | 2017 |
In-vivo effects of knocking-down metabotropic glutamate receptor 5 in the SOD1
Topics: Amyotrophic Lateral Sclerosis; Animals; Astrocytes; Cell Death; Cell Survival; Disease Models, Animal; Disease Progression; Female; Glutamic Acid; Humans; Male; Mice, Transgenic; Microglia; Motor Neurons; Motor Skills; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Sex Factors; Spinal Cord; Superoxide Dismutase-1 | 2017 |
Effect of Class II HDAC inhibition on glutamate transporter expression and survival in SOD1-ALS mice.
Topics: Amino Acid Transport System X-AG; Amyotrophic Lateral Sclerosis; Animals; Astrocytes; Cells, Cultured; Excitatory Amino Acid Transporter 2; Female; Glutamic Acid; Histone Deacetylase Inhibitors; Histone Deacetylases; Hydroxamic Acids; Male; Mice, Transgenic; Pyrroles; Spinal Cord; Superoxide Dismutase-1 | 2017 |
Massive transcriptome sequencing of human spinal cord tissues provides new insights into motor neuron degeneration in ALS.
Topics: Amyotrophic Lateral Sclerosis; Autopsy; Calcium; Cell Death; Gene Expression Regulation; Glutamic Acid; High-Throughput Nucleotide Sequencing; Humans; Male; MicroRNAs; Middle Aged; Motor Neurons; Nerve Tissue Proteins; Neuroglia; RNA, Messenger; Signal Transduction; Spinal Cord; Synapses; Synaptosomal-Associated Protein 25; Syntaxin 1; Transcriptome | 2017 |
Pathologic Involvement of Glutamatergic Striatal Inputs From the Cortices in TAR DNA-Binding Protein 43 kDa-Related Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis.
Topics: Afferent Pathways; Aged; Aged, 80 and over; Amyloid beta-Peptides; Amyotrophic Lateral Sclerosis; Autopsy; Axons; Case-Control Studies; Cerebral Cortex; Corpus Striatum; DNA-Binding Proteins; Female; Frontotemporal Lobar Degeneration; Glutamic Acid; Humans; Male; Middle Aged; Neurons; Retrospective Studies; RNA-Binding Proteins | 2017 |
Membrane cholesterol depletion in cortical neurons highlights altered NMDA receptor functionality in a mouse model of amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; beta-Cyclodextrins; Cell Membrane; Cell Survival; Cholesterol; Disease Models, Animal; Electrophysiology; Female; Glutamic Acid; Humans; Male; Membrane Microdomains; Mice; Mice, Transgenic; Motor Neurons; N-Methylaspartate; Proteomics; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Superoxide Dismutase-1 | 2018 |
Constitutive downregulation protein kinase C epsilon in hSOD1
Topics: Amino Acid Transport System X-AG; Amyotrophic Lateral Sclerosis; Animals; Astrocytes; Calcium; Calcium Signaling; Cations, Divalent; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Down-Regulation; Glutamic Acid; HEK293 Cells; Humans; Protein Kinase C-epsilon; Rats, Sprague-Dawley; Rats, Transgenic; Receptor, Metabotropic Glutamate 5; Superoxide Dismutase-1 | 2018 |
Downregulation of glutamic acid decarboxylase in Drosophila TDP-43-null brains provokes paralysis by affecting the organization of the neuromuscular synapses.
Topics: Amyotrophic Lateral Sclerosis; Animals; Brain; Cell Line; DNA-Binding Proteins; Down-Regulation; Drosophila; Drosophila Proteins; Glutamate Decarboxylase; Glutamic Acid; Humans; Locomotion; Motor Activity; Motor Neurons; Mutation; Neuroglia; Neuromuscular Junction; Paralysis; Receptors, Glutamate; Synapses | 2018 |
Motor neuron-derived microRNAs cause astrocyte dysfunction in amyotrophic lateral sclerosis.
Topics: Amino Acid Transport System X-AG; Amyotrophic Lateral Sclerosis; Animals; Astrocytes; Cells, Cultured; Disease Models, Animal; Down-Regulation; Excitatory Amino Acid Transporter 2; Glutamic Acid; HEK293 Cells; Humans; Mice; Mice, Inbred C57BL; MicroRNAs; Motor Neurons; Neuroglia | 2018 |
Evaluation of neuroprotective effects of wedelolactone and gallic acid on aluminium-induced neurodegeneration: Relevance to sporadic amyotrophic lateral sclerosis.
Topics: Aluminum; Amyotrophic Lateral Sclerosis; Animals; Body Weight; Brain-Derived Neurotrophic Factor; Caspase 3; Coumarins; Female; Gallic Acid; Gene Expression Regulation; Glutamic Acid; Interleukin-6; Male; Mice; Neuroprotective Agents; Rats; Rotarod Performance Test; Tumor Necrosis Factor-alpha | 2018 |
Single copy/knock-in models of ALS SOD1 in C. elegans suggest loss and gain of function have different contributions to cholinergic and glutamatergic neurodegeneration.
Topics: Amino Acid Sequence; Amyotrophic Lateral Sclerosis; Animals; Animals, Genetically Modified; Base Sequence; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Cholinergic Neurons; CRISPR-Cas Systems; Disease Models, Animal; Gain of Function Mutation; Gene Frequency; Gene Knock-In Techniques; Glutamic Acid; Humans; Loss of Function Mutation; Motor Neurons; Superoxide Dismutase; Superoxide Dismutase-1 | 2018 |
Microphysiological 3D model of amyotrophic lateral sclerosis (ALS) from human iPS-derived muscle cells and optogenetic motor neurons.
Topics: Amyotrophic Lateral Sclerosis; Animals; Calcium Signaling; Electric Stimulation; Gene Expression; Glutamic Acid; Humans; Induced Pluripotent Stem Cells; Lab-On-A-Chip Devices; Mice; Motor Neurons; Muscle Contraction; Muscle Fibers, Skeletal; Muscle, Skeletal; Neuromuscular Junction; Optogenetics; Spheroids, Cellular | 2018 |
Targeting Protein Kinase CK1δ with Riluzole: Could It Be One of the Possible Missing Bricks to Interpret Its Effect in the Treatment of ALS from a Molecular Point of View?
Topics: Amyotrophic Lateral Sclerosis; Astrocytes; Casein Kinase Idelta; Glutamic Acid; Humans; Molecular Docking Simulation; Molecular Targeted Therapy; Neuroprotective Agents; Protein Binding; Protein Conformation; Riluzole; Thermodynamics | 2018 |
Neurochemical correlates of functional decline in amyotrophic lateral sclerosis.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Case-Control Studies; Disease Progression; Female; Glutamic Acid; Humans; Longitudinal Studies; Male; Middle Aged; Motor Cortex; Motor Neurons; Pons; Prognosis; Proton Magnetic Resonance Spectroscopy; Upper Extremity | 2019 |
Excess glutamate secreted from astrocytes drives upregulation of P-glycoprotein in endothelial cells in amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Astrocytes; ATP Binding Cassette Transporter, Subfamily B; Blood-Brain Barrier; Capillaries; Cells, Cultured; Culture Media, Conditioned; Dizocilpine Maleate; Endothelial Cells; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Mutation; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Superoxide Dismutase-1; Up-Regulation | 2019 |
The RNA-binding protein FUS/TLS undergoes calcium-mediated nuclear egress during excitotoxic stress and is required for
Topics: Active Transport, Cell Nucleus; Amyotrophic Lateral Sclerosis; Calcium; Cell Nucleus; Cytoplasm; Frontotemporal Dementia; Glutamic Acid; Humans; Mutation; Neurons; Receptors, AMPA; RNA Processing, Post-Transcriptional; RNA-Binding Protein FUS; RNA, Messenger; Stress, Physiological | 2019 |
Membralin deficiency dysregulates astrocytic glutamate homeostasis leading to ALS-like impairment.
Topics: Amyotrophic Lateral Sclerosis; Animals; Astrocytes; Down-Regulation; Excitatory Amino Acid Transporter 2; Glutamic Acid; Humans; Mice; Mice, Knockout; Motor Cortex; Nerve Tissue Proteins; Receptors, Tumor Necrosis Factor, Type I; Superoxide Dismutase; Transcription, Genetic; Up-Regulation | 2019 |
An imbalance between excitatory and inhibitory neurotransmitters in amyotrophic lateral sclerosis revealed by use of 3-T proton magnetic resonance spectroscopy.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Biomarkers; Case-Control Studies; Down-Regulation; Excitatory Amino Acid Antagonists; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Cortex; Neural Inhibition; Riluzole; Up-Regulation | 2013 |
RNA toxicity from the ALS/FTD C9ORF72 expansion is mitigated by antisense intervention.
Topics: Adenosine Deaminase; Amyotrophic Lateral Sclerosis; C9orf72 Protein; Cell Count; Dose-Response Relationship, Drug; Frontotemporal Dementia; Glutamic Acid; Humans; Induced Pluripotent Stem Cells; Neurons; Oligonucleotides, Antisense; Proteins; Repetitive Sequences, Nucleic Acid; RNA; RNA-Binding Proteins | 2013 |
Knocking down metabotropic glutamate receptor 1 improves survival and disease progression in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Astrocytes; Catalase; Disease Progression; Excitatory Amino Acid Transporter 2; Glutamic Acid; Metallothionein; Mice; Mice, Transgenic; Microglia; Mitochondria; Motor Activity; Motor Neurons; Point Mutation; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; RNA, Messenger; Severity of Illness Index; Spinal Cord; Superoxide Dismutase; Superoxide Dismutase-1; Survival Analysis | 2014 |
Sumoylation of the astroglial glutamate transporter EAAT2 governs its intracellular compartmentalization.
Topics: Amyotrophic Lateral Sclerosis; Animals; Astrocytes; Caspase 3; Cell Membrane; Disease Models, Animal; Excitatory Amino Acid Transporter 2; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; HEK293 Cells; Humans; Intracellular Space; Mice, Transgenic; Prosencephalon; Rats, Sprague-Dawley; Spinal Cord; Sumoylation | 2014 |
Exocytosis regulates trafficking of GABA and glycine heterotransporters in spinal cord glutamatergic synapses: a mechanism for the excessive heterotransporter-induced release of glutamate in experimental amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Disease Models, Animal; Exocytosis; Female; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Glutamic Acid; Glycine Plasma Membrane Transport Proteins; Humans; Male; Mice; Mice, Knockout; Mice, Transgenic; Nerve Tissue Proteins; Spinal Cord; Superoxide Dismutase; Superoxide Dismutase-1; Synapses; Synaptosomes | 2015 |
GLT1 overexpression in SOD1(G93A) mouse cervical spinal cord does not preserve diaphragm function or extend disease.
Topics: Amyotrophic Lateral Sclerosis; Animals; Astrocytes; Cervical Cord; Dependovirus; Diaphragm; Disease Models, Animal; Disease Progression; Excitatory Amino Acid Transporter 2; Female; Genetic Vectors; Glutamic Acid; Injections, Spinal; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Motor Neurons; Superoxide Dismutase | 2015 |
DJ-1 knockout augments disease severity and shortens survival in a mouse model of ALS.
Topics: Amyotrophic Lateral Sclerosis; Animals; Cell Line; Cell Survival; Disease Models, Animal; Female; Gliosis; Glutamic Acid; Humans; Intracellular Signaling Peptides and Proteins; Male; Mice; Mice, Knockout; Mice, Transgenic; Motor Neurons; Mutation; NF-E2-Related Factor 2; Oncogene Proteins; Peptides; Protein Deglycase DJ-1; Severity of Illness Index; Spinal Cord; Superoxide Dismutase; Superoxide Dismutase-1 | 2015 |
C9orf72 BAC Transgenic Mice Display Typical Pathologic Features of ALS/FTD.
Topics: Age Factors; Amyotrophic Lateral Sclerosis; Animals; Brain; C9orf72 Protein; Cells, Cultured; Chromosomes, Artificial, Bacterial; Disease Models, Animal; DNA Repeat Expansion; Frontotemporal Dementia; Glutamic Acid; Humans; Mice; Mice, Transgenic; Motor Activity; Muscle Strength; Neuromuscular Junction; Neurons; Proteins; Psychomotor Performance; Spinal Cord | 2015 |
Multifactorial Gene Therapy Enhancing the Glutamate Uptake System and Reducing Oxidative Stress Delays Symptom Onset and Prolongs Survival in the SOD1-G93A ALS Mouse Model.
Topics: Amyotrophic Lateral Sclerosis; Animals; Cells, Cultured; Genetic Therapy; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Humans; Mice; Mice, Inbred C57BL; Mutation, Missense; NF-E2-Related Factor 2; Oxidative Stress; Sugar Alcohol Dehydrogenases; Superoxide Dismutase; Superoxide Dismutase-1 | 2016 |
The ratio of N-acetyl aspartate to glutamate correlates with disease duration of amyotrophic lateral sclerosis.
Topics: Aged; Aging; Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Cell Death; Cross-Sectional Studies; Female; Glutamic Acid; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Cortex; Neurons | 2016 |
Voltage-gated calcium channels are abnormal in cultured spinal motoneurons in the G93A-SOD1 transgenic mouse model of ALS.
Topics: Amyotrophic Lateral Sclerosis; Animals; Calcium; Calcium Channels; Disease Models, Animal; Glutamic Acid; Mice, Transgenic; Motor Neurons; Spinal Cord; Superoxide Dismutase-1 | 2016 |
Nicotinic receptor activation contrasts pathophysiological bursting and neurodegeneration evoked by glutamate uptake block on rat hypoglossal motoneurons.
Topics: Action Potentials; Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Brain Stem; Endoplasmic Reticulum Stress; Glucosyltransferases; Glutamic Acid; Hypoglossal Nerve; Motor Neurons; Neurodegenerative Diseases; Nicotine; Nicotinic Antagonists; Rats; Rats, Wistar; Reactive Oxygen Species; Receptors, Nicotinic | 2016 |
Glutamate release and uptake processes are altered in a new mouse model of amyotrophic lateral sclerosis.
Topics: Aging; Amyotrophic Lateral Sclerosis; Animals; Cations, Monovalent; Central Nervous System Agents; Cerebral Cortex; Disease Models, Animal; Glutamic Acid; Mice, Transgenic; Potassium; Potassium Chloride; RNA-Binding Protein FUS; Sodium; Synaptosomes; Tritium | 2016 |
Altered mechanisms underlying the abnormal glutamate release in amyotrophic lateral sclerosis at a pre-symptomatic stage of the disease.
Topics: Actins; Amyotrophic Lateral Sclerosis; Animals; Disease Models, Animal; Exocytosis; Glutamic Acid; Mice, Transgenic; Receptors, Presynaptic; Spinal Cord; Superoxide Dismutase; Synaptosomes | 2016 |
Gingival Stromal Cells as an In Vitro Model: Cannabidiol Modulates Genes Linked With Amyotrophic Lateral Sclerosis.
Topics: Adult Stem Cells; Amyotrophic Lateral Sclerosis; Cannabidiol; Cells, Cultured; Gene Expression; Gene Expression Profiling; Genes, Mitochondrial; Genetic Therapy; Gingiva; Glutamic Acid; High-Throughput Nucleotide Sequencing; Humans; In Vitro Techniques; Mesenchymal Stem Cells; Oxidative Stress | 2017 |
Localization of a mutant SOD1 protein in E40K-heterozygous dogs: Implications for non-cell-autonomous pathogenesis of degenerative myelopathy.
Topics: Amyotrophic Lateral Sclerosis; Animals; Antibodies; Calcium-Binding Proteins; Disease Models, Animal; DNA-Binding Proteins; Dogs; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Glutamic Acid; HEK293 Cells; Humans; Immunoprecipitation; Lysine; Microfilament Proteins; Mutation; Spinal Cord; Superoxide Dismutase-1; Transfection | 2017 |
Altered Metabolic Profiles Associate with Toxicity in SOD1
Topics: Amyotrophic Lateral Sclerosis; Animals; Astrocytes; Coculture Techniques; Disease Models, Animal; Glucose; Glutamic Acid; Metabolome; Mice; Motor Neurons; Oxidative Stress; Superoxide Dismutase-1 | 2017 |
FUS inclusions disrupt RNA localization by sequestering kinesin-1 and inhibiting microtubule detyrosination.
Topics: Amyotrophic Lateral Sclerosis; Animals; Cell Line; Cytoplasm; Glutamic Acid; Inclusion Bodies; Kinesins; Mice; Microtubules; Mutation; NIH 3T3 Cells; Protein Transport; RNA; RNA-Binding Protein FUS; RNA-Binding Proteins; RNA, Messenger; Sarcoma; Tubulin; Tubulin Modulators; Tyrosine | 2017 |
Deregulation of PKN1 activity disrupts neurofilament organisation and axonal transport.
Topics: Amyotrophic Lateral Sclerosis; Animals; Axonal Transport; Caspase 3; Disease Models, Animal; Glutamic Acid; Humans; Male; Mice; Mice, Transgenic; Neurofilament Proteins; Neurons; Protein Kinase C; Rats; Spinal Cord; Superoxide Dismutase; Superoxide Dismutase-1 | 2008 |
Nordihydroguaiaretic acid increases glutamate uptake in vitro and in vivo: therapeutic implications for amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line; Central Nervous System; Cyclooxygenase Inhibitors; Drug Resistance; Glutamic Acid; Humans; Masoprocol; Mice; Mice, Transgenic; Neurotoxins; Presynaptic Terminals; Superoxide Dismutase; Superoxide Dismutase-1; Synaptic Transmission; Treatment Failure; Up-Regulation | 2008 |
Oxidative and excitotoxic insults exert differential effects on spinal motoneurons and astrocytic glutamate transporters: Implications for the role of astrogliosis in amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Anterior Horn Cells; Astrocytes; Cell Survival; Cells, Cultured; Coculture Techniques; Cytoprotection; Excitatory Amino Acid Agonists; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Glial Fibrillary Acidic Protein; Gliosis; Glutamic Acid; Homeostasis; Mice; Mice, Inbred C57BL; Molsidomine; Neurotoxins; Nitric Oxide Donors; Oxidative Stress; Time Factors | 2009 |
Amyotrophic lateral sclerosis linked to a novel SOD1 mutation with muscle mitochondrial dysfunction.
Topics: Adult; Amyotrophic Lateral Sclerosis; Arginine; Cytochromes c; DNA Mutational Analysis; Family Health; Genetic Linkage; Genetic Predisposition to Disease; Glutamic Acid; Humans; Male; Mitochondria, Muscle; Mitochondrial Diseases; Mutation; Superoxide Dismutase; Superoxide Dismutase-1 | 2009 |
Rethinking a drug treatment failure on a traditional ALS target.
Topics: Amyotrophic Lateral Sclerosis; Animals; Disease Models, Animal; Excitatory Amino Acid Transporter 2; Glutamic Acid; Humans; Masoprocol; Treatment Failure | 2009 |
Hyperexcitability, persistent Na+ conductances and neurodegeneration in amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Biophysical Phenomena; Cerebral Cortex; Glutamic Acid; Humans; Nerve Degeneration; Neural Conduction; Sodium Channels | 2009 |
beta-N-methylamino-l-alanine induces oxidative stress and glutamate release through action on system Xc(-).
Topics: Amino Acid Transport System y+; Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Animals; Cells, Cultured; Central Nervous System; Coculture Techniques; Cyanobacteria Toxins; Cystine; Excitatory Amino Acid Agonists; Extracellular Space; Glutamic Acid; Glutathione; Mice; Neurodegenerative Diseases; Neurons; Neurotoxins; Oxidative Stress; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate | 2009 |
Characterization of chronic glutamate-mediated motor neuron toxicity in organotypic spinal cord culture prepared from ALS model mice.
Topics: Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Caspase 12; Cell Death; Cell Survival; Disease Models, Animal; Enzyme Activation; Glial Cell Line-Derived Neurotrophic Factor; Glutamic Acid; Mice; Mice, Transgenic; Motor Neurons; Organ Culture Techniques; Spinal Cord; Superoxide Dismutase | 2009 |
Abnormal sensitivity of cannabinoid CB1 receptors in the striatum of mice with experimental amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Corpus Striatum; Disease Models, Animal; Dronabinol; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Genotype; Glutamic Acid; Male; Mice; Mice, Mutant Strains; Nerve Degeneration; Neural Inhibition; Neuroprotective Agents; Receptor, Cannabinoid, CB1; Superoxide Dismutase; Superoxide Dismutase-1; Synaptic Transmission | 2010 |
Epigenetic regulation of neuron-dependent induction of astroglial synaptic protein GLT1.
Topics: Amyotrophic Lateral Sclerosis; Animals; Animals, Newborn; Astrocytes; Cells, Cultured; Central Nervous System; CpG Islands; DNA Methylation; Epigenesis, Genetic; Excitatory Amino Acid Transporter 2; Gene Expression Regulation; Glutamic Acid; Humans; Mice; Mice, Transgenic; Motor Cortex; Motor Neurons; Nerve Degeneration; Neurons; Neurotoxins; Promoter Regions, Genetic; Repressor Proteins; Synapses; Synaptic Transmission | 2010 |
Defining the mechanisms that underlie cortical hyperexcitability in amyotrophic lateral sclerosis.
Topics: Action Potentials; Adult; Aged; Amyotrophic Lateral Sclerosis; Cerebral Cortex; Electromagnetic Fields; Excitatory Postsynaptic Potentials; Female; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Interneurons; Male; Membrane Potentials; Middle Aged; Neural Inhibition; Neural Pathways; Neurons; Pyramidal Cells; Pyramidal Tracts; Synaptic Transmission; Transcranial Magnetic Stimulation | 2009 |
In vitro neurotoxic properties and excitatory aminoacids concentration in the cerebrospinal fluid of amyotrophic lateral sclerosis patients. Relationship with the degree of certainty of disease diagnoses.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Cell Survival; Cells, Cultured; Cerebral Cortex; Cerebrospinal Fluid; Female; Glutamic Acid; Humans; Male; Mice; Middle Aged; Neurons; Time Factors | 2010 |
Early excitability changes in lumbar motoneurons of transgenic SOD1G85R and SOD1G(93A-Low) mice.
Topics: Amyotrophic Lateral Sclerosis; Animals; Arginine; Biophysical Phenomena; Biophysics; Calcium Channel Blockers; Disease Models, Animal; Electric Stimulation; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; In Vitro Techniques; Interneurons; Lumbosacral Region; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Nifedipine; Patch-Clamp Techniques; Riluzole; Spinal Cord; Superoxide Dismutase; Superoxide Dismutase-1 | 2009 |
Magnetic resonance spectroscopy of regional brain metabolite markers in FALS mice and the effects of dietary creatine supplementation.
Topics: Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Biomarkers; Brain; Creatine; Disease Models, Animal; Glutamic Acid; Glutamine; In Vitro Techniques; Inositol; Linear Models; Magnetic Resonance Spectroscopy; Mice; Mice, Transgenic; Protons; Spectrum Analysis; Superoxide Dismutase | 2009 |
Methionine sulfoximine, an inhibitor of glutamine synthetase, lowers brain glutamine and glutamate in a mouse model of ALS.
Topics: Amyotrophic Lateral Sclerosis; Animals; Biomarkers; Corpus Striatum; Disease Models, Animal; Down-Regulation; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamate-Ammonia Ligase; Glutamic Acid; Glutamine; Glutathione; Humans; Kaplan-Meier Estimate; Magnetic Resonance Spectroscopy; Methionine Sulfoximine; Mice; Mice, Transgenic; Motor Cortex; Neuroprotective Agents; Neurotoxins; Oxidative Stress; Superoxide Dismutase; Superoxide Dismutase-1; Treatment Outcome | 2010 |
Metabolomic analysis of serum by (1) H NMR spectroscopy in amyotrophic lateral sclerosis.
Topics: 3-Hydroxybutyric Acid; Acetates; Acetone; Adult; Amyotrophic Lateral Sclerosis; Female; Formates; Glutamic Acid; Glutamine; Histidine; Humans; Magnetic Resonance Spectroscopy; Male; Protons; Sensitivity and Specificity | 2010 |
In vitro activation of GAT1 transporters expressed in spinal cord gliosomes stimulates glutamate release that is abnormally elevated in the SOD1/G93A(+) mouse model of amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Calcium; Chelating Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Egtazic Acid; GABA Agents; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Gene Expression Regulation; Gliosis; Glutamic Acid; Humans; L-Lactate Dehydrogenase; Mice; Mice, Transgenic; Nerve Tissue Proteins; Nipecotic Acids; Spinal Cord; Superoxide Dismutase | 2010 |
Human adipose-derived stem cells enhance the glutamate uptake function of GLT1 in SOD1(G93A)-bearing astrocytes.
Topics: Adipose Tissue; Amyotrophic Lateral Sclerosis; Animals; Astrocytes; Caspase Inhibitors; Cells, Cultured; Coculture Techniques; Excitatory Amino Acid Transporter 2; Glutamic Acid; Hepatocyte Growth Factor; Humans; Insulin-Like Growth Factor I; Mice; Mice, Transgenic; Stem Cells; Superoxide Dismutase; Superoxide Dismutase-1; Up-Regulation; Vascular Endothelial Growth Factor A | 2010 |
Cocaine use and abuse triggering sporadic young-onset amyotrophic lateral sclerosis.
Topics: Adult; Age of Onset; Amyotrophic Lateral Sclerosis; Cocaine; Cocaine-Related Disorders; Glutamic Acid; Humans; Male; Motor Neurons; Nerve Degeneration; Receptors, Glutamate | 2011 |
TNF-α potentiates glutamate-induced spinal cord motoneuron death via NF-κB.
Topics: Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Cell Death; Excitatory Amino Acid Transporter 2; Glutamic Acid; Humans; Inflammation; Motor Neurons; NF-kappa B; Organ Culture Techniques; Oxidative Stress; Rats; Signal Transduction; Spinal Cord; Tumor Necrosis Factor-alpha | 2011 |
Abnormal exocytotic release of glutamate in a mouse model of amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Analysis of Variance; Animals; Animals, Inbred Strains; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Glutamic Acid; Humans; Ionomycin; Mice; Mice, Transgenic; Microscopy, Confocal; Neurotransmitter Agents; Potassium Chloride; Spinal Cord; Superoxide Dismutase; Synapsins; Synaptosomes; Time Factors; Tritium | 2011 |
Riluzole is a potent drug to protect neonatal rat hypoglossal motoneurons in vitro from excitotoxicity due to glutamate uptake block.
Topics: Action Potentials; Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Astrocytes; Bicuculline; Biomarkers; Convulsants; Excitatory Amino Acid Antagonists; GABA-A Receptor Antagonists; Glutamic Acid; Hypoglossal Nerve; Motor Neurons; Neuroprotective Agents; Patch-Clamp Techniques; Rats; Riluzole; Strychnine | 2011 |
Complex behavioral and synaptic effects of dietary branched chain amino acids in a mouse model of amyotrophic lateral sclerosis.
Topics: Amino Acids, Branched-Chain; Amyotrophic Lateral Sclerosis; Animals; Behavior, Animal; Brain; Diet; Dietary Supplements; Glucose Transporter Type 1; Glutamic Acid; Hyperkinesis; In Vitro Techniques; Male; Mice; Mice, Transgenic; Nerve Tissue Proteins; Neurons; Organ Specificity; Pain Threshold; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Severity of Illness Index; Synaptic Transmission; Time Factors | 2011 |
[Different distribution of NMDA receptor subunits in cortex contributes to selective vulnerability of motor neurons in amyotrophic lateral sclerosis].
Topics: Amino Acid Transport System X-AG; Amyotrophic Lateral Sclerosis; Animals; Animals, Newborn; Cells, Cultured; Cerebral Cortex; Fetus; Glutamic Acid; Mice; Mice, Inbred C57BL; Motor Neurons; Receptors, N-Methyl-D-Aspartate | 2011 |
Glutamate and glutathione interplay in a motor neuronal model of amyotrophic lateral sclerosis reveals altered energy metabolism.
Topics: Amyotrophic Lateral Sclerosis; Animals; Cell Communication; Cell Line; Disease Models, Animal; Energy Metabolism; Glutamic Acid; Glutathione; Humans; Mice; Mice, Transgenic; Mitochondrial Diseases; Models, Neurological; Motor Neurons | 2011 |
Exposure to an environmental neurotoxicant hastens the onset of amyotrophic lateral sclerosis-like phenotype in human Cu2+/Zn2+ superoxide dismutase 1 G93A mice: glutamate-mediated excitotoxicity.
Topics: Amyotrophic Lateral Sclerosis; Animals; Excitatory Amino Acid Agonists; Genetic Predisposition to Disease; Glutamic Acid; Humans; Male; Methylmercury Compounds; Mice; Mice, Transgenic; Phenotype; Superoxide Dismutase | 2011 |
Substance P receptor activation induces downregulation of the AMPA receptor functionality in cortical neurons from a genetic model of Amyotrophic Lateral Sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Blotting, Western; Cell Survival; Cells, Cultured; Cerebral Cortex; Down-Regulation; Electrophysiological Phenomena; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Humans; Immunohistochemistry; Kainic Acid; Mice; Mice, Transgenic; Neurokinin-1 Receptor Antagonists; Neurons; Patch-Clamp Techniques; Receptors, AMPA; Receptors, Neurokinin-1; Synaptic Transmission | 2011 |
Sera from amyotrophic lateral sclerosis patients induce the non-canonical activation of NMDA receptors "in vitro".
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Animals; Blood Proteins; Calcium Signaling; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Female; Glutamic Acid; Humans; In Vitro Techniques; Male; Middle Aged; Nerve Degeneration; Neurotoxins; Oocytes; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Xenopus laevis | 2011 |
A mutation in sigma-1 receptor causes juvenile amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Apoptosis; Cell Line; Child; Child, Preschool; Chromosome Mapping; Chromosomes, Human, Pair 9; Cloning, Molecular; Enzyme Inhibitors; Family Health; Female; Genetic Predisposition to Disease; Glutamic Acid; Glutamine; Humans; In Situ Nick-End Labeling; Infant; Male; Mice; Motor Neurons; Mutagenesis, Site-Directed; Phenotype; Polymorphism, Single Nucleotide; Receptors, sigma; Saudi Arabia; Sigma-1 Receptor; Thapsigargin; Transfection | 2011 |
Sterol regulatory element binding protein-1 (SREBP1) activation in motor neurons in excitotoxicity and amyotrophic lateral sclerosis (ALS): Indip, a potential therapeutic peptide.
Topics: Amino Acid Sequence; Amyotrophic Lateral Sclerosis; Animals; Cells, Cultured; Cytoprotection; Glutamic Acid; Humans; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Molecular Sequence Data; Motor Neurons; Neurotoxins; Peptides; Spinal Cord; Sterol Regulatory Element Binding Protein 1 | 2011 |
Dysregulation of astrocyte-motoneuron cross-talk in mutant superoxide dismutase 1-related amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Astrocytes; Cell Communication; Cell Death; Cells, Cultured; Coculture Techniques; Disease Models, Animal; Disease Progression; Glutamic Acid; Humans; Lactic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microarray Analysis; Motor Neurons; Nerve Growth Factor; Receptor, Nerve Growth Factor; Signal Transduction; Superoxide Dismutase | 2011 |
Different clinical and neuropathologic phenotypes of familial ALS with A315E TARDBP mutation.
Topics: Adult; Aged; Alanine; Amyotrophic Lateral Sclerosis; DNA-Binding Proteins; Family Health; Female; Genetic Testing; Glutamic Acid; Humans; Japan; Male; Middle Aged; Mutation; Phenotype; Psychiatric Status Rating Scales | 2011 |
Group I metabotropic glutamate autoreceptors induce abnormal glutamate exocytosis in a mouse model of amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Autoreceptors; Calcium; Disease Models, Animal; Excitatory Amino Acid Antagonists; Exocytosis; Female; Glutamic Acid; Glycine; Humans; Inositol Phosphates; Lumbar Vertebrae; Male; Mice; Mice, Neurologic Mutants; Mice, Transgenic; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Resorcinols; Spinal Cord; Superoxide Dismutase; Superoxide Dismutase-1; Synaptosomes | 2013 |
[Gene therapy and neurotrophic factor treatment for amyotrophic lateral sclerosis].
Topics: Amyotrophic Lateral Sclerosis; Animals; Apoptosis; Cells, Cultured; Disease Models, Animal; Free Radicals; Genetic Therapy; Glial Cell Line-Derived Neurotrophic Factor; Glutamic Acid; Humans; Mice; Mice, Transgenic; Nerve Growth Factors; Oxidative Stress; Rats; Rats, Sprague-Dawley; Spinal Cord | 2001 |
Quantitative assessment of AMPA receptor mRNA in human spinal motor neurons isolated by laser capture microdissection.
Topics: Aged; Amyotrophic Lateral Sclerosis; Cell Death; Down-Regulation; Female; Gene Expression; Glutamic Acid; Humans; Male; Middle Aged; Motor Neurons; Neurotoxins; Posterior Horn Cells; Receptors, AMPA; RNA, Messenger; Spinal Cord; Synaptic Transmission | 2002 |
Human glioma cells and undifferentiated primary astrocytes that express aberrant EAAT2 mRNA inhibit normal EAAT2 protein expression and prevent cell death.
Topics: 5' Untranslated Regions; Alternative Splicing; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Apoptosis; Astrocytes; Clone Cells; Excitatory Amino Acid Transporter 2; Exons; Gene Expression Regulation; Glioma; Glutamic Acid; Humans; Neurotransmitter Uptake Inhibitors; RNA, Messenger; Synaptic Transmission; Tumor Cells, Cultured | 2002 |
Impaired spinal cord glutamate transport capacity and reduced sensitivity to riluzole in a transgenic superoxide dismutase mutant rat model of amyotrophic lateral sclerosis.
Topics: Amino Acid Transport System X-AG; Amyotrophic Lateral Sclerosis; Animals; Animals, Genetically Modified; Disease Models, Animal; Disease Progression; Drug Resistance; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Excitatory Amino Acid Transporter 3; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Humans; Immunoblotting; Neuroprotective Agents; Organ Specificity; Rats; Rats, Mutant Strains; Rats, Sprague-Dawley; Riluzole; Spinal Cord; Superoxide Dismutase; Symporters; Synaptosomes; Transgenes | 2003 |
Therapeutic vaccine for acute and chronic motor neuron diseases: implications for amyotrophic lateral sclerosis.
Topics: Acute Disease; Amyotrophic Lateral Sclerosis; Animals; Axotomy; Cell Death; Chronic Disease; Disease Models, Animal; Facial Nerve; Female; Glatiramer Acetate; Glutamic Acid; Humans; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Motor Neuron Disease; Motor Neurons; Nerve Degeneration; Peptides; Superoxide Dismutase; Superoxide Dismutase-1; Vaccines | 2003 |
Activation of a glycine transporter on spinal cord neurons causes enhanced glutamate release in a mouse model of amyotrophic lateral sclerosis.
Topics: Age Factors; Amino Acid Transport Systems, Neutral; Amyotrophic Lateral Sclerosis; Animals; D-Aspartic Acid; Disease Models, Animal; Female; gamma-Aminobutyric Acid; Gene Expression; Glutamic Acid; Glycine; Glycine Plasma Membrane Transport Proteins; Humans; Mice; Mice, Transgenic; Mutation; Neurons; Spinal Cord; Superoxide Dismutase; Superoxide Dismutase-1; Synaptosomes; Tritium | 2003 |
Disruption of glial glutamate transport by reactive oxygen species produced in motor neurons.
Topics: Amyotrophic Lateral Sclerosis; Animals; Astrocytes; Biological Transport; Cells, Cultured; Coculture Techniques; Feedback, Physiological; Glutamic Acid; Mice; Mice, Transgenic; Motor Neurons; Neuroglia; Neurons; Oxidation-Reduction; Reactive Oxygen Species; Spinal Cord; Superoxide Dismutase; Superoxide Dismutase-1 | 2003 |
Human spinal motoneurons express low relative abundance of GluR2 mRNA: an implication for excitotoxicity in ALS.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Cell Separation; Female; Glutamic Acid; Humans; Lasers; Male; Middle Aged; Motor Neurons; Neurotoxins; Protein Subunits; Purkinje Cells; Pyramidal Cells; Receptors, AMPA; Receptors, Glutamate; Reference Values; Reverse Transcriptase Polymerase Chain Reaction; RNA Editing; RNA, Messenger; Spinal Cord | 2003 |
Decrease in glial glutamate transporter variants and excitatory amino acid receptor down-regulation in a murine model of ALS-PDC.
Topics: Amyotrophic Lateral Sclerosis; Animals; Blood Vessels; Central Nervous System; Disease Models, Animal; Down-Regulation; Excitatory Amino Acid Transporter 2; Glutamic Acid; Immunohistochemistry; Male; Mice; Mice, Inbred Strains; Neuroglia; Neurons; Neurotoxins; Plant Extracts; Protein Isoforms; Receptors, GABA-A; Receptors, Glutamate; Up-Regulation | 2003 |
High threshold for induction of the stress response in motor neurons is associated with failure to activate HSF1.
Topics: Amyotrophic Lateral Sclerosis; Animals; Cells, Cultured; Cysteine Endopeptidases; Disease Models, Animal; DNA-Binding Proteins; Enzyme Inhibitors; Gene Expression Regulation; Genes, Reporter; Glutamic Acid; Heat Shock Transcription Factors; Heat-Shock Proteins; Heat-Shock Response; Hot Temperature; HSP70 Heat-Shock Proteins; Humans; In Vitro Techniques; Mice; Mice, Transgenic; Motor Neurons; Multienzyme Complexes; Promoter Regions, Genetic; Proteasome Endopeptidase Complex; Spinal Cord; Superoxide Dismutase; Transcription Factors | 2003 |
Glutamate carboxypeptidase II inhibition protects motor neurons from death in familial amyotrophic lateral sclerosis models.
Topics: Adenoviridae; Amyotrophic Lateral Sclerosis; Animals; Carboxypeptidases; Cell Death; Cell Survival; Enzyme Inhibitors; Glutamate Carboxypeptidase II; Glutamic Acid; Mice; Mice, Transgenic; Motor Neurons; Neurons; Time Factors | 2003 |
Increased expression of the glial glutamate transporter EAAT2 modulates excitotoxicity and delays the onset but not the outcome of ALS in mice.
Topics: Amyotrophic Lateral Sclerosis; Animals; Brain; Caspases; Cell Death; Cell Membrane; Crosses, Genetic; Disease Models, Animal; Enzyme Activation; Excitatory Amino Acid Transporter 2; Gene Expression; Glial Fibrillary Acidic Protein; Glutamic Acid; Mice; Mice, Transgenic; Motor Neurons; Promoter Regions, Genetic; Spinal Cord; Superoxide Dismutase; Superoxide Dismutase-1; Time Factors; Transgenes | 2003 |
Premorbid weight, body mass, and varsity athletics in ALS.
Topics: 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide); Amino Acids, Branched-Chain; Amyotrophic Lateral Sclerosis; Astrocytes; Body Weight; Case-Control Studies; Dietary Supplements; Genetic Predisposition to Disease; Glutamic Acid; Humans; Italy; Middle Aged; Mitochondria; Pyramidal Cells; Sports; Transaminases | 2003 |
Magnesium supplementation does not delay disease onset or increase survival in a mouse model of familial ALS.
Topics: Age of Onset; Amyotrophic Lateral Sclerosis; Animals; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Hand Strength; Magnesium; Mice; Mice, Transgenic; Muscle Weakness; Receptors, N-Methyl-D-Aspartate; Superoxide Dismutase; Superoxide Dismutase-1; Survival Rate; Treatment Failure | 2003 |
Molecular signature of late-stage human ALS revealed by expression profiling of postmortem spinal cord gray matter.
Topics: Amyotrophic Lateral Sclerosis; Cysteine Endopeptidases; Discriminant Analysis; Gene Expression Profiling; Glutamic Acid; Humans; Inflammation; Mitochondria; Multienzyme Complexes; Nerve Tissue Proteins; Neurons; Neurotransmitter Agents; Oligonucleotide Array Sequence Analysis; Oxidative Stress; Proteasome Endopeptidase Complex; RNA, Messenger; Signal Transduction; Spinal Cord; Transcription, Genetic | 2004 |
Identification of two novel mutations in the Cu/Zn superoxide dismutase gene with familial amyotrophic lateral sclerosis: mass spectrometric and genomic analyses.
Topics: Age of Onset; Amyotrophic Lateral Sclerosis; Aspartic Acid; Chromatography, Liquid; DNA Mutational Analysis; Erythrocytes; Exons; Family Health; Female; Glutamic Acid; Glycine; Histidine; Humans; Male; Molecular Biology; Molecular Sequence Data; Mutation; Precipitin Tests; Spectrometry, Mass, Electrospray Ionization; Superoxide Dismutase | 2004 |
Excessive and precocious glutamate release in a mouse model of amyotrophic lateral sclerosis.
Topics: Amino Acids; Amyotrophic Lateral Sclerosis; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Glutamic Acid; Humans; Mice; Mice, Inbred C57BL; Mice, Transgenic; Superoxide Dismutase; Superoxide Dismutase-1; Synaptosomes | 2004 |
Differential expression of mGluR5 in human lumbosacral motoneurons.
Topics: Amyotrophic Lateral Sclerosis; Disease Susceptibility; Glutamic Acid; Humans; Immunohistochemistry; Lumbosacral Region; Male; Motor Neurons; Neurotoxins; Parasympathetic Nervous System; Pelvic Floor; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Spinal Cord | 2004 |
Activated microglia initiate motor neuron injury by a nitric oxide and glutamate-mediated mechanism.
Topics: Amino Acid Transport System X-AG; Amyotrophic Lateral Sclerosis; Animals; Astrocytes; Catalase; Cell Communication; Cell Death; Cells, Cultured; Coculture Techniques; Free Radicals; Glutamic Acid; Glutathione; Microglia; Motor Neurons; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidative Stress; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Spinal Cord | 2004 |
Increased internalisation and degradation of GLT-1 glial glutamate transporter in a cell model for familial amyotrophic lateral sclerosis (ALS).
Topics: Amyotrophic Lateral Sclerosis; Animals; Biological Transport; Biotinylation; Blotting, Western; Cell Line; Disease Models, Animal; DNA, Complementary; Dogs; Down-Regulation; Endocytosis; Excitatory Amino Acid Transporter 2; Glutamic Acid; Humans; Immunohistochemistry; Microscopy, Fluorescence; Models, Biological; Mutation; Neurons; Oxidative Stress; Plasmids; Protein Isoforms; Superoxide Dismutase; Time Factors; Transfection | 2004 |
Altered vulnerability to kainate excitotoxicity of transgenic-Cu/Zn SOD1 neurones.
Topics: Amyotrophic Lateral Sclerosis; Analysis of Variance; Animals; Asparagine; Calcium Channel Blockers; Cell Count; Cell Survival; Cells, Cultured; Cerebral Cortex; Cobalt; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; Female; Glial Fibrillary Acidic Protein; Glutamic Acid; Immunohistochemistry; Kainic Acid; Male; Mice; Mice, Transgenic; Motor Neurons; Neurotoxins; Nifedipine; Phosphopyruvate Hydratase; Sodium Channel Blockers; Spinal Cord; Superoxide Dismutase; Tetrodotoxin; Time Factors | 2004 |
Medicine. Treating neurodegenerative diseases with antibiotics.
Topics: Amyotrophic Lateral Sclerosis; Animals; Anti-Bacterial Agents; beta-Lactams; Brain; Ceftriaxone; Clinical Trials as Topic; Drug Evaluation, Preclinical; Excitatory Amino Acid Transporter 2; Glutamic Acid; Humans; Mice; Motor Neurons; Neurodegenerative Diseases; Spinal Cord; Synapses; Synaptic Transmission | 2005 |
Impairment of glutamate transport and increased vulnerability to oxidative stress in neuroblastoma SH-SY5Y cells expressing a Cu,Zn superoxide dismutase typical of familial amyotrophic lateral sclerosis.
Topics: Amino Acid Transport System X-AG; Amyotrophic Lateral Sclerosis; Antioxidants; Biological Transport, Active; Brain Neoplasms; Cell Line, Tumor; Electrophoresis, Agar Gel; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Excitatory Amino Acid Transporter 3; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Humans; Kinetics; Mutation; Neuroblastoma; Oxidants; Oxidative Stress; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sodium; Superoxide Dismutase; Symporters | 2005 |
Amyotrophic lateral sclerosis--a new role for old drugs.
Topics: Amyotrophic Lateral Sclerosis; Animals; Anti-Bacterial Agents; Ceftriaxone; Disease Models, Animal; Drug Evaluation, Preclinical; Excitatory Amino Acid Transporter 2; Glutamic Acid; Mice; Neuroprotective Agents | 2005 |
Glyoxal inactivates glutamate transporter-1 in cultured rat astrocytes.
Topics: Amino Acid Transport System X-AG; Amyotrophic Lateral Sclerosis; Animals; Animals, Newborn; Astrocytes; Cells, Cultured; Chromatography, High Pressure Liquid; Glutamic Acid; Glyoxal; Immunoblotting; Immunohistochemistry; Lysine; Rats | 2005 |
Merits of a new drug trial for ALS?
Topics: Amino Acid Transport System X-AG; Amyotrophic Lateral Sclerosis; Animals; Anti-Bacterial Agents; Biological Transport; Ceftriaxone; Clinical Trials as Topic; Glutamic Acid; Humans; Rats; Spinal Cord | 2005 |
Glutamate release induced by activation of glycine and GABA transporters in spinal cord is enhanced in a mouse model of amyotrophic lateral sclerosis.
Topics: Algorithms; Amyotrophic Lateral Sclerosis; Animals; DNA, Complementary; GABA Plasma Membrane Transport Proteins; Glutamic Acid; Glycine Plasma Membrane Transport Proteins; Humans; Mice; Mice, Transgenic; Spinal Cord; Superoxide Dismutase; Superoxide Dismutase-1; Synaptosomes | 2005 |
Protein retention in the endoplasmic reticulum, blockade of programmed cell death and autophagy selectively occur in spinal cord motoneurons after glutamate receptor-mediated injury.
Topics: Amyotrophic Lateral Sclerosis; Animals; Anterior Horn Cells; Apoptosis; Autophagy; Axotomy; Chick Embryo; Disease Models, Animal; Endoplasmic Reticulum; Excitatory Amino Acid Agonists; Glutamic Acid; Inclusion Bodies; Microscopy, Electron, Transmission; Models, Neurological; N-Methylaspartate; Nerve Tissue Proteins; Neurofilament Proteins; Neurotoxins; Protein Biosynthesis; Receptors, Glutamate; Stress, Physiological | 2005 |
Identification of candidate drugs for the treatment of ALS.
Topics: Amyotrophic Lateral Sclerosis; Animals; Antioxidants; Cell Count; Cells, Cultured; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Interactions; Embryo, Mammalian; Enzyme Inhibitors; GABA Modulators; Glutamic Acid; In Situ Nick-End Labeling; Ion Channels; Motor Neurons; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; Spinal Cord | 2005 |
DJ-1 mutations and parkinsonism-dementia-amyotrophic lateral sclerosis complex.
Topics: Amyotrophic Lateral Sclerosis; Blotting, Northern; Dementia; DNA Mutational Analysis; Exons; Family Health; Female; Glutamic Acid; Humans; Intracellular Signaling Peptides and Proteins; Male; Mucoproteins; Mutation; Oncogene Proteins; Parkinsonian Disorders; Protein Deglycase DJ-1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2005 |
Cerebral neurons of transgenic ALS mice are vulnerable to glutamate release stimulation but not to increased extracellular glutamate due to transport blockade.
Topics: 4-Aminopyridine; Amyotrophic Lateral Sclerosis; Animals; Biological Transport; Dicarboxylic Acids; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Extracellular Space; Glutamic Acid; HSP72 Heat-Shock Proteins; Humans; Mice; Mice, Transgenic; Microdialysis; Neurons; Neurotransmitter Uptake Inhibitors; Pyrrolidines; Superoxide Dismutase | 2006 |
Loss of metabotropic glutamate receptor-mediated regulation of glutamate transport in chemically activated astrocytes in a rat model of amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Animals, Genetically Modified; Aspartic Acid; Astrocytes; Blotting, Northern; Calcium; Carbachol; Cholinergic Agonists; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Excitatory Amino Acid Transporter 2; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Glutamic Acid; Humans; Immunohistochemistry; Male; Methoxyhydroxyphenylglycol; Protein Kinase C; Pyridines; Rats; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sodium; Superoxide Dismutase; Tritium | 2006 |
Caspase-3 cleaves and inactivates the glutamate transporter EAAT2.
Topics: Amino Acid Sequence; Amyotrophic Lateral Sclerosis; Animals; Caspase 3; Caspases; Cell Membrane; Excitatory Amino Acid Transporter 2; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Humans; Mice; Molecular Sequence Data; Oocytes; Rats; Superoxide Dismutase; Superoxide Dismutase-1 | 2006 |
Sporadic ALS is not associated with VAPB gene mutations in Southern Italy.
Topics: Adult; Aged; Aged, 80 and over; Amino Acid Substitution; Amyotrophic Lateral Sclerosis; Aspartic Acid; Base Sequence; Case-Control Studies; Exons; Female; Gene Frequency; Genetic Variation; Glutamic Acid; Humans; Introns; Italy; Male; Middle Aged; Mutation; Vesicular Transport Proteins | 2006 |
Protective effect of metabotropic glutamate receptor inhibition on amyotrophic lateral sclerosis-cerebrospinal fluid toxicity in vitro.
Topics: Aged; Amyotrophic Lateral Sclerosis; Animals; Cell Count; Cell Death; Cells, Cultured; Cerebrospinal Fluid; Chick Embryo; Coculture Techniques; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Glycine; Humans; Immunohistochemistry; In Situ Nick-End Labeling; Indans; Indoles; Lectins; Male; Middle Aged; Motor Neurons; Receptors, Metabotropic Glutamate; Spinal Cord; Time Factors | 2006 |
X-Linked inhibitor of apoptosis protein gene-based neuroprotection for the peripheral nervous system.
Topics: Amyotrophic Lateral Sclerosis; Apoptosis; Caspase 3; Caspases; Cell Count; Cell Line; Cell Survival; Diabetic Neuropathies; Feasibility Studies; Ganglia, Spinal; Gene Expression; Gene Transfer Techniques; Glutamic Acid; Green Fluorescent Proteins; Humans; Motor Neurons; Neuroprotective Agents; Peripheral Nervous System; Recombinant Fusion Proteins; X-Linked Inhibitor of Apoptosis Protein | 2006 |
Temporospatial coupling of networked synaptic activation of AMPA-type glutamate receptor channels and calcium transients in cultured motoneurons.
Topics: Amyotrophic Lateral Sclerosis; Animals; Calcium; Calcium Channels; Calcium Signaling; Cells, Cultured; Coculture Techniques; Endoplasmic Reticulum; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Motor Neurons; Nerve Net; Neural Pathways; Neurotoxins; Patch-Clamp Techniques; Rats; Receptors, AMPA; Ryanodine Receptor Calcium Release Channel; Sodium Channels; Spinal Cord; Synaptic Transmission; Time Factors | 2006 |
Astroglial alterations in amyotrophic lateral sclerosis (ALS) model of slow glutamate excitotoxicity in vitro.
Topics: Amyotrophic Lateral Sclerosis; Animals; Astrocytes; Disease Models, Animal; Excitatory Amino Acid Antagonists; Glutamic Acid; Microscopy, Electron, Transmission; Motor Neurons; Nerve Degeneration; Organ Culture Techniques; Rats; Spinal Cord | 2006 |
[Etiological drug therapy for amyotrophic lateral sclerosis].
Topics: Amyotrophic Lateral Sclerosis; Glutamic Acid; Humans; Neuroprotective Agents; Oxidative Stress; Riluzole | 2006 |
Changes in immune and glial markers in the CSF of patients with Complex Regional Pain Syndrome.
Topics: Aged; Amyotrophic Lateral Sclerosis; Biomarkers; Calcium; Chemokines; Complex Regional Pain Syndromes; Cytokines; Female; Glial Fibrillary Acidic Protein; Glucose; Glutamic Acid; Humans; Hydrocephalus; Male; Middle Aged; Neuroglia; Nitrates; Nitric Oxide; Nitrites; Peripheral Nervous System Diseases; Radiculopathy; Spondylolisthesis | 2007 |
Altered in-vitro and in-vivo expression of glial glutamate transporter-1 following exposure to cerebrospinal fluid of amyotrophic lateral sclerosis patients.
Topics: Amyotrophic Lateral Sclerosis; Animals; Animals, Newborn; Astrocytes; Biological Factors; Cell Death; Cells, Cultured; Cerebrospinal Fluid; Enzyme Inhibitors; Excitatory Amino Acid Transporter 2; Female; Glutamic Acid; Humans; Immunohistochemistry; Injections, Spinal; L-Lactate Dehydrogenase; Male; Middle Aged; Neurotoxins; NG-Nitroarginine Methyl Ester; Presynaptic Terminals; Rats; Spinal Cord; Up-Regulation | 2007 |
Neuroscience. Astrocytes secrete substance that kills motor neurons in ALS.
Topics: Amyotrophic Lateral Sclerosis; Animals; Astrocytes; Cell Death; Cell Line; Cells, Cultured; Embryonic Stem Cells; Glutamic Acid; Humans; Mice; Motor Neurons; Mutation; Superoxide Dismutase | 2007 |
Inhibition of Pin1 reduces glutamate-induced perikaryal accumulation of phosphorylated neurofilament-H in neurons.
Topics: Alzheimer Disease; Amyotrophic Lateral Sclerosis; Animals; Apoptosis; Cell Nucleus; Ganglia, Spinal; Genes, Dominant; Glutamic Acid; Humans; Models, Biological; Naphthoquinones; Neurofilament Proteins; Neurons; NIMA-Interacting Peptidylprolyl Isomerase; Peptidylprolyl Isomerase; Phosphorylation; Protein Binding; Protein Structure, Quaternary; Protein Transport; Rats; RNA, Small Interfering; Spinal Cord; Transfection | 2007 |
D-serine is a key determinant of glutamate toxicity in amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Disease Models, Animal; Enzyme Activation; Enzyme Induction; Extracellular Signal-Regulated MAP Kinases; Glutamic Acid; Humans; Mice; Mice, Transgenic; Middle Aged; Motor Neurons; Mutation; N-Methylaspartate; Neuroglia; p38 Mitogen-Activated Protein Kinases; Racemases and Epimerases; Serine; Spinal Cord; Superoxide Dismutase; Up-Regulation | 2007 |
Plasma glutamate and glycine levels in patients with amyotrophic lateral sclerosis: the effect of riluzole treatment.
Topics: Aged; Amyotrophic Lateral Sclerosis; Chromatography, High Pressure Liquid; Disease Progression; Female; Glutamic Acid; Glycine; Humans; Male; Middle Aged; Neuroprotective Agents; Riluzole; Sex Characteristics | 2008 |
Altered presymptomatic AMPA and cannabinoid receptor trafficking in motor neurons of ALS model mice: implications for excitotoxicity.
Topics: Amyotrophic Lateral Sclerosis; Animals; Cell Death; Disease Models, Animal; Down-Regulation; Female; Glutamic Acid; Humans; Male; Mice; Mice, Transgenic; Motor Neurons; Nerve Degeneration; Neural Inhibition; Neurotoxins; Protein Transport; Receptor, Cannabinoid, CB1; Receptors, AMPA; Spinal Cord; Synaptic Transmission; Up-Regulation | 2008 |
Riluzole for amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Controlled Clinical Trials as Topic; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Muscles; Riluzole; Sodium Channels; Thiazoles; Tracheostomy; Treatment Outcome | 1995 |
Decreased thermal stability of red blood cell glu100-->gly superoxide dismutase from a family with amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Enzyme Stability; Erythrocytes; Glutamic Acid; Glycine; Humans; Point Mutation; Superoxide Dismutase | 1995 |
Effect of branched-chain amino acids on glutamate metabolism in amyotrophic lateral sclerosis.
Topics: Adult; Amino Acids, Branched-Chain; Amyotrophic Lateral Sclerosis; Aspartic Acid; Female; Glutamic Acid; Humans; Male; Middle Aged | 1995 |
[Free amino acid contents in the spinal cord of amyotrophic lateral sclerosis].
Topics: Aged; Amino Acids; Amyotrophic Lateral Sclerosis; Aspartic Acid; Female; Glutamates; Glutamic Acid; Humans; Male; Middle Aged; Neurotransmitter Agents; Spinal Cord | 1993 |
Chronic inhibition of superoxide dismutase produces apoptotic death of spinal neurons.
Topics: Acetylcysteine; Amyotrophic Lateral Sclerosis; Animals; Animals, Newborn; Anti-Anxiety Agents; Antioxidants; Apoptosis; Base Sequence; Benzodiazepines; Biological Transport; Choline O-Acetyltransferase; Chromans; Ditiocarb; Glutamates; Glutamic Acid; Humans; Molecular Sequence Data; Motor Neurons; Nerve Degeneration; Neurotoxins; Oligonucleotides, Antisense; Organ Culture Techniques; Piperazines; Rats; Spinal Cord; Superoxide Dismutase | 1994 |
A new variant Cu/Zn superoxide dismutase (Val7-->Glu) deduced from lymphocyte mRNA sequences from Japanese patients with familial amyotrophic lateral sclerosis.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Base Sequence; DNA Primers; Female; Glutamic Acid; Humans; Japan; Lymphocytes; Male; Middle Aged; Molecular Sequence Data; Mutation; RNA, Messenger; Superoxide Dismutase; Valine | 1994 |
Cortical excitability in amyotrophic lateral sclerosis: a clue to pathogenesis.
Topics: Action Potentials; Aged; Amyotrophic Lateral Sclerosis; Cerebral Cortex; Electromagnetic Fields; Evoked Potentials; Female; Glutamates; Glutamic Acid; Humans; Male; Middle Aged; Motor Neurons; Muscles | 1993 |
Amyotrophic lateral sclerosis: what makes the direct corticospinal tract so vulnerable.
Topics: Amyotrophic Lateral Sclerosis; Animals; Electrophysiology; Glutamates; Glutamic Acid; Humans; Models, Neurological; Neurotoxins; Pyramidal Tracts | 1993 |
Overview of the pathogenesis and therapy of amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Antibodies, Monoclonal; Autoimmunity; Glutamic Acid; Humans; Nerve Growth Factors; Neurotoxins | 1995 |
Identification of brain metabolites by magnetic resonance spectroscopy in MND/ALS.
Topics: Amyotrophic Lateral Sclerosis; Aspartic Acid; Brain; Brain Chemistry; Creatine; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Humans; Magnetic Resonance Spectroscopy | 1996 |
Neuroscientists seek answers to brain function and disease. Faulty protein linked to ALS.
Topics: Amyotrophic Lateral Sclerosis; Excitatory Amino Acid Transporter 2; Glutamic Acid; Humans; Introns; Motor Cortex; Receptors, Neurotransmitter; RNA, Messenger; Spinal Cord | 1996 |
Increased CSF glutamate following injection of ALS immunoglobulins.
Topics: Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Glutamic Acid; Immunoglobulins; Injections, Intraperitoneal; Rats; Reference Values; Time Factors | 1997 |
Immunoglobulins from motoneurone disease patients enhance glutamate release from rat hippocampal neurones in culture.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Animals; Cells, Cultured; Electric Stimulation; Electrophysiology; Female; Glutamic Acid; Hippocampus; Humans; Immunoglobulins; Male; Membrane Potentials; Middle Aged; Motor Neuron Disease; Neurons; Patch-Clamp Techniques; Rats; Receptors, Glutamate; Synapses | 1997 |
In vivo and in vitro studies of glycine- and glutamate-evoked acetylcholinesterase release from spinal motor neurones: implications for amyotrophic lateral sclerosis/motor neurone disease pathogenesis.
Topics: Acetylcholinesterase; Amyotrophic Lateral Sclerosis; Animals; Calcium; Glutamic Acid; Glycine; Histocytochemistry; Male; Mice; Motor Neuron Disease; Motor Neurons; Receptors, AMPA; Spinal Cord | 1997 |
Amyotrophic lateral sclerosis, excitotoxicity and riluzole.
Topics: Amyotrophic Lateral Sclerosis; Clinical Trials as Topic; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Neuroprotective Agents; Riluzole; Synaptic Transmission | 1998 |
Aberrant RNA processing in a neurodegenerative disease: the cause for absent EAAT2, a glutamate transporter, in amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Base Sequence; Central Nervous System; Cloning, Molecular; COS Cells; Down-Regulation; Excitatory Amino Acid Transporter 2; Exons; Glutamic Acid; Humans; Introns; Molecular Sequence Data; Protein Biosynthesis; Receptors, Neurotransmitter; RNA Precursors; RNA Processing, Post-Transcriptional; RNA, Messenger | 1998 |
Glutamate uptake is decreased tardively in the spinal cord of FALS mice.
Topics: Amyotrophic Lateral Sclerosis; Animals; Biological Transport, Active; Glutamic Acid; Hand Strength; In Vitro Techniques; Kinetics; Medulla Oblongata; Mice; Mice, Neurologic Mutants; Spinal Cord; Survival Analysis; Synaptosomes | 1998 |
Blood glutamate levels in patients with motor neuron disease.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Bulbar Palsy, Progressive; Female; Glutamic Acid; Humans; Male; Middle Aged; Motor Neuron Disease | 1998 |
Mechanism of selective motor neuronal death after exposure of spinal cord to glutamate: involvement of glutamate-induced nitric oxide in motor neuron toxicity and nonmotor neuron protection.
Topics: Amyotrophic Lateral Sclerosis; Animals; Cell Death; Cell Survival; Cells, Cultured; Cyclic GMP; Dicarboxylic Acids; Embryo, Mammalian; Glutamic Acid; Models, Neurological; Motor Neurons; N-Methylaspartate; Neurons; Neurotransmitter Uptake Inhibitors; Nitric Oxide; Nitric Oxide Donors; Pyrrolidines; Rats; Rats, Wistar; Spinal Cord | 1998 |
1H-MRS evidence of neurodegeneration and excess glutamate + glutamine in ALS medulla.
Topics: Adult; Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Brain; Female; Glutamic Acid; Glutamine; Humans; Hydrogen; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Medulla Oblongata; Middle Aged; Nerve Degeneration; Reference Values | 1999 |
Glutamate enhances phosphorylation of neurofilaments in cerebellar granule cell culture.
Topics: Amyotrophic Lateral Sclerosis; Animals; Animals, Newborn; Cell Culture Techniques; Cerebellum; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Neurofilament Proteins; Neurons; Phosphorylation; Rats; Rats, Sprague-Dawley | 1999 |
ALS-linked Cu/Zn-SOD mutation impairs cerebral synaptic glucose and glutamate transport and exacerbates ischemic brain injury.
Topics: Amyotrophic Lateral Sclerosis; Animals; Biological Transport; Brain Ischemia; Cerebral Cortex; Glucose; Glutamic Acid; Humans; Mice; Mice, Transgenic; Mutation; Superoxide Dismutase; Synapses | 2000 |
Elevated cortical extracellular fluid glutamate in transgenic mice expressing human mutant (G93A) Cu/Zn superoxide dismutase.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amino Acid Transport System X-AG; Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; ATP-Binding Cassette Transporters; Cerebral Cortex; Extracellular Space; Gene Expression Regulation, Enzymologic; Glutamic Acid; Humans; Hydroxyindoleacetic Acid; Mice; Mice, Neurologic Mutants; Mice, Transgenic; Microdialysis; Phenotype; Superoxide Dismutase | 2000 |
[Physiopathological and chemopathological mechanisms of central motor disorders in amyotrophic lateral sclerosis].
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Brain; Electromyography; Female; Glutamic Acid; Glycine; Humans; Male; Middle Aged; Motor Neurons | 2000 |
Amyotrophic lateral sclerosis-linked glutamate transporter mutant has impaired glutamate clearance capacity.
Topics: Amino Acid Substitution; Amino Acid Transport System X-AG; Amyotrophic Lateral Sclerosis; Animals; ATP-Binding Cassette Transporters; Biological Transport; Cell Membrane; COS Cells; Cytoplasm; Electric Conductivity; Fluorescent Antibody Technique; Genes, Dominant; Glutamic Acid; Glycosylation; Humans; Kainic Acid; Microinjections; Mutation; Oocytes; RNA, Complementary; Sodium Glutamate; Transfection; Xenopus laevis | 2001 |
Decreased platelet glutamate uptake in patients with amyotrophic lateral sclerosis.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Analysis of Variance; Biomarkers; Blood Platelets; Female; Glutamic Acid; Humans; Male; Middle Aged | 2001 |
Nitrotyrosination contributes minimally to toxicity of mutant SOD1 associated with ALS.
Topics: Amyotrophic Lateral Sclerosis; Animals; Cell Death; Cell Survival; Cells, Cultured; Embryo, Mammalian; Enzyme Inhibitors; Glutamic Acid; Humans; Mice; Motor Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Superoxide Dismutase; Tyrosine | 2001 |
EAAT1 and EAAT2 immunoreactivity in transgenic mice with a G93A mutant SOD1 gene.
Topics: Aging; Amino Acid Transport System X-AG; Amyotrophic Lateral Sclerosis; Animals; ATP-Binding Cassette Transporters; Disease Models, Animal; Excitatory Amino Acid Transporter 2; Glutamic Acid; Immunohistochemistry; Mice; Mice, Transgenic; Motor Neurons; Mutation; Nerve Degeneration; Posterior Horn Cells; Receptors, Neurotransmitter; Spinal Cord; Superoxide Dismutase; Superoxide Dismutase-1 | 2001 |
RPR 119990, a novel alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid antagonist: synthesis, pharmacological properties, and activity in an animal model of amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Anticonvulsants; Disease Progression; Electrophysiology; Electroshock; Excitatory Amino Acid Antagonists; Glutamic Acid; Imidazoles; In Vitro Techniques; Longevity; Mice; Mice, Transgenic; Muscle, Skeletal; Neurons; Patch-Clamp Techniques; Pyrazines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Superoxide Dismutase | 2001 |
Amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Glutamic Acid; Humans; Motor Neurons; Receptors, AMPA | 2001 |
Functional diversity of recombinant human AMPA type glutamate receptors: possible implications for selective vulnerability of motor neurons.
Topics: Alternative Splicing; Amyotrophic Lateral Sclerosis; Cell Line; Glutamic Acid; Humans; Kidney; Membrane Potentials; Motor Neurons; Patch-Clamp Techniques; Protein Isoforms; Reaction Time; Receptors, AMPA; Recombinant Proteins; Transfection | 2001 |
Nitric oxide produced by non-motoneuron cells enhances rat embryonic motoneuron sensitivity to excitotoxins: comparison in mixed neuron/glia or purified cultures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amyotrophic Lateral Sclerosis; Animals; Anterior Horn Cells; Cell Communication; Cell Differentiation; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Drug Resistance; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fetus; Glutamic Acid; Glycine; Kainic Acid; Magnesium; N-Methylaspartate; Neuroglia; Neurotoxins; Nitric Oxide; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate | 2001 |
Transgenic SOD1 G93A mice develop reduced GLT-1 in spinal cord without alterations in cerebrospinal fluid glutamate levels.
Topics: Amino Acid Transport System X-AG; Amyotrophic Lateral Sclerosis; Animals; Behavior, Animal; Blotting, Western; Disease Models, Animal; Disease Progression; Excitatory Amino Acid Transporter 2; Glial Fibrillary Acidic Protein; Glutamic Acid; Immunohistochemistry; In Situ Hybridization; Mice; Mice, Transgenic; RNA, Messenger; Spinal Cord; Superoxide Dismutase | 2001 |
Differential cortico-motoneuron vulnerability after chronic mitochondrial inhibition in vitro and the role of glutamate receptors.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Amyotrophic Lateral Sclerosis; Animals; Animals, Newborn; Cell Death; Cell Survival; Cerebral Cortex; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Energy Metabolism; Excitatory Amino Acid Antagonists; Glutamic Acid; Immunohistochemistry; Malonates; Mitochondria; Motor Neurons; Neurofilament Proteins; Neuroprotective Agents; Organ Culture Techniques; Pyramidal Tracts; Rats; Rats, Wistar; Receptors, Glutamate | 2001 |
Glutamate levels in cerebrospinal fluid in amyotrophic lateral sclerosis: a reappraisal using a new HPLC method with coulometric detection in a large cohort of patients.
Topics: Age Factors; Aged; Amyotrophic Lateral Sclerosis; Cerebrospinal Fluid; Chromatography, High Pressure Liquid; Cohort Studies; Colorimetry; Disease Progression; Female; Glutamic Acid; Humans; Male; Middle Aged; Muscle Weakness; Neurons; Paresis; Rhombencephalon; Sex Factors; Spinal Cord | 2002 |
GLT-1 glutamate transporter levels are unchanged in mice expressing G93A human mutant SOD1.
Topics: Aging; Amino Acid Transport System X-AG; Amyotrophic Lateral Sclerosis; Animals; Carrier Proteins; Central Nervous System; Dimerization; Disease Models, Animal; Electrophoresis, Polyacrylamide Gel; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Excitatory Amino Acid Transporter 3; Female; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Humans; Immunohistochemistry; Male; Mice; Mice, Transgenic; Molecular Weight; Motor Neurons; Muscle Weakness; Mutation; Phenotype; Superoxide Dismutase; Superoxide Dismutase-1; Symporters | 2002 |
DL-Homocysteic acid application disrupts calcium homeostasis and induces degeneration of spinal motor neurons in vivo.
Topics: Amyotrophic Lateral Sclerosis; Animals; Anterior Horn Cells; Calcium; Calcium Signaling; Cell Death; Disease Models, Animal; Glutamic Acid; Homeostasis; Homocysteine; Male; Microscopy, Electron; Rats; Rats, Inbred Strains | 2002 |
Amyotrophic lateral sclerosis and glutamate--too much of a good thing?
Topics: Amyotrophic Lateral Sclerosis; Glutamates; Glutamic Acid; Humans; Synaptosomes | 1992 |
Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis.
Topics: Aged; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Biological Transport; Brain; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Humans; Huntington Disease; In Vitro Techniques; Male; Middle Aged; Motor Cortex; Phenylalanine; Somatosensory Cortex; Spinal Cord; Synaptosomes; Visual Cortex | 1992 |
Glutamate and aspartate are decreased in the skin in amyotrophic lateral sclerosis.
Topics: Aged; Amino Acids; Amyotrophic Lateral Sclerosis; Aspartic Acid; Biopsy; Collagen; Female; Glutamates; Glutamic Acid; Humans; Male; Middle Aged; Reference Values; Skin | 1992 |
Excitatory amino acids in amyotrophic lateral sclerosis: an update.
Topics: Amyotrophic Lateral Sclerosis; Aspartic Acid; Chromatography, High Pressure Liquid; Glutamates; Glutamic Acid; Humans; Prospective Studies | 1991 |
Reductions in acidic amino acids and N-acetylaspartylglutamate in amyotrophic lateral sclerosis CNS.
Topics: Amino Acids; Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Aspartic Acid; Cerebral Cortex; Dipeptides; Glutamates; Glutamic Acid; Humans; Motor Cortex; Reference Values; Spinal Cord | 1991 |
Glutamate dysfunction and selective motor neuron degeneration in amyotrophic lateral sclerosis: a hypothesis.
Topics: Amyotrophic Lateral Sclerosis; Central Nervous System; Glutamate Dehydrogenase; Glutamates; Glutamic Acid; Glycine; Humans; Motor Neurons; Nerve Endings; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses | 1990 |
Plasma glutamate levels in normal subjects and in patients with amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Erythrocytes; Glutamates; Glutamic Acid; Humans; Plasma; Sodium Glutamate | 1990 |
Brain glutamate deficiency in amyotrophic lateral sclerosis.
Topics: Amino Acids; Amyotrophic Lateral Sclerosis; Brain Chemistry; Glutamates; Glutamic Acid; Humans; Middle Aged | 1987 |
Abnormal glutamate metabolism in amyotrophic lateral sclerosis.
Topics: Administration, Oral; Adult; Aged; Amino Acids; Amyotrophic Lateral Sclerosis; Glutamate Dehydrogenase; Glutamates; Glutamic Acid; Humans; Leukocytes; Middle Aged; Sodium Glutamate | 1987 |
The neuroexcitotoxic amino acids glutamate and aspartate are altered in the spinal cord and brain in amyotrophic lateral sclerosis.
Topics: Aged; Amino Acids; Amyotrophic Lateral Sclerosis; Aspartic Acid; Brain; Cerebellar Cortex; Cerebral Cortex; Glutamates; Glutamic Acid; Humans; Middle Aged; Neurotoxins; Reference Values; Spinal Cord | 1988 |