glutamic acid and Acute Confusional Senile Dementia

glutamic acid has been researched along with Acute Confusional Senile Dementia in 514 studies

Research

Studies (514)

Timeframe	Studies, this research(%)	All Research%
pre-1990	31 (6.03)	18.7374
1990's	73 (14.20)	18.2507
2000's	157 (30.54)	29.6817
2010's	177 (34.44)	24.3611
2020's	76 (14.79)	2.80

Authors

Authors	Studies
Emptage, NJ; Jeans, AF; Taylor, HBC	1
Andersen, ML; Dokkedal-Silva, V; Piovezan, RD; Tufik, S; Vitti-Ruela, BV	1
Chen, L; Song, J; Wang, C; Yang, X; Zhang, M	1
Alfiler, L; Anastassiou, C; Arkhipov, A; Baker, K; Bakken, TE; Barkan, E; Barzo, P; Beller, A; Berg, J; Bernard, A; Berry, K; Bertagnolli, D; Bickley, K; Bomben, J; Braun, T; Brouner, K; Buchin, A; Budzillo, A; Casper, T; Chartrand, T; Chong, P; Cobbs, C; Crichton, K; D'Orazi, F; Dalley, R; de Frates, R; de Kock, CPJ; de Witt Hamer, PC; Dee, N; Desta, T; Ding, SL; Dotson, N; Egdorf, T; Ellenbogen, RG; Enstrom, R; Esposito, L; Farrell, C; Feng, D; Ferreira, M; Fong, O; Furdan, S; Galakhova, AA; Gamlin, C; Gary, A; Glandon, A; Goldy, J; Gorham, M; Goriounova, NA; Gouwens, NW; Gratiy, S; Graybuck, L; Gu, H; Gwinn, RP; Hadley, K; Hansen, N; Hawrylycz, MJ; Heistek, TS; Henry, AM; Heyer, DB; Hill, C; Hill, D; Hodge, RD; Hof, PR; Hupp, M; Idema, S; Jarsky, T; Jones, AR; Kalmbach, B; Kebede, S; Keene, CD; Keene, L; Kim, L; Kim, MH; Ko, AL; Koch, C; Kroll, M; Latimer, C; Lee, BR; Lee, C; Lee, SD; Lein, ES; Levi, BP; Link, KE; Mallory, M; Mann, R; Mansvelder, HD; Marshall, D; Maxwell, M; McGraw, M; McMillen, D; Melief, E; Mertens, EJ; Mezei, L; Mihut, N; Miller, JA; Mok, S; Molnar, G; Mukora, A; Murphy, GJ; Ng, L; Ngo, K; Nicovich, PR; Nyhus, J; Ojemann, JG; Olah, G; Oldre, A; Omstead, V; Ozsvar, A; Park, D; Patel, AP; Peng, H; Pham, T; Phillips, JW; Pom, CA; Potekhina, L; Rajanbabu, R; Ransford, S; Reid, D; Rimorin, C; Ruiz, A; Sandman, D; Segev, I; Silbergeld, DL; Smith, K; Sorensen, SA; Sulc, J; Sunkin, SM; Szafer, A; Szemenyei, V; Tamas, G; Tasic, B; Thomsen, ER; Tieu, M; Ting, JT; Torkelson, A; Trinh, J; Tung, H; Wakeman, W; Waleboer, F; Ward, K; Wilbers, R; Williams, G; Yao, Z; Yoon, JG; Yuste, R; Zeng, H	1
Dou, Y; Liu, X; Tan, Y; Xie, J; Zhang, M; Zhao, Y	1
Bhattacharya, S; Hong, H; Hunsberger, HC; McDonald, KL; Pfitzer, JC; Reed, MN; Rudy, CC; Setti, SE; Suppiramaniam, V; Weitzner, DS	1
Czapski, GA; Strosznajder, JB	1
Jin, H; Jin, QH; Li, YS; Ren, P; Wang, LP; Xiao, B	1
Konnerth, A; Zott, B	1
Kobayashi, S; Ohashi, S; Takashima, A; Tanaka, T	1
Dąbrowska-Bouta, B; Strosznajder, R; Struzynska, L; Sulkowski, G; Wencel, PL	1
Li, S; Stern, AM	1
Lecarpentier, Y; Vallée, A; Vallée, JN	1
Andersen, JV; Schousboe, A; Verkhratsky, A	1
Nadkarni, S; Pillai, AG	1
Dacorro, L; Fingerhut, H; Gozdas, E; Gu, M; Hinkley, L; Hosseini, SMH; Hurd, R; Sacchet, MD	1
Boscia, F; de Rosa, V; Pannaccione, A; Piccialli, I; Secondo, A; Sisalli, MJ; Tedeschi, V	1
López-Gil, X; Muñoz-Moreno, E; Simões, RV; Soria, G; Tudela, R	1
Cho, KM; Jo, JK; Kim, EJ; Kim, HW; Kim, JH; Kwon, SJ; Lee, G; Nguyen, CD; Park, SE; Seo, SH; Son, HS	1
Avgerinos, KI; Chen, Q; Egan, JM; Kapogiannis, D; Melvin, D; Mullins, RJ; Mustapic, M; Vreones, M	1
Chowdari Gurram, P; Kodi, T; Mudgal, J; Nampoothiri, M; Nassar, A; Satarker, S; Sm, F; Upadhya, D	1
Bowman, AB; Buchanan, RA; Consoli, DC; Harrison, FE; Nobis, WP; Spitznagel, BD; Thibert, MK	1
Barnes, JR; Barron, JC; Brymer, KJ; Hurley, EP; Mukherjee, B; Nafar, F; Parsons, MP	1
Dahlmanns, JK; Dahlmanns, M; Savaskan, N; Steiner, HH; Yakubov, E	1
Amatore, C; Huang, WH; Jiao, YT; Jin, XK; Liu, YL; Yang, XK; Zhang, FL; Zhang, XW	1
Hu, VW; Prasansuklab, A; Sarachana, T; Sukjamnong, S; Tencomnao, T; Theerasri, A	1
Bedi, PMS; Chadha, R; Kaur, J; Kaur, R; Kaur, U; Sharma, A; Singh, A; Singh, K	1
Cai, J; Dai, J; Qin, T; Song, C; Sun, T; Xie, D; Xu, Y; Zhai, Z	1
Chaurasia, RN; Dash, D; Gautam, D; Naik, MU; Naik, UP; Yadav, SK	1
Chen-Engerer, HJ; Frosch, MP; Hong, W; Konnerth, A; Sakmann, B; Simon, MM; Unger, F; Walsh, DM; Zott, B	1
Cao, T; Chang, Z; Chu, Q; Liu, Y; Lu, J; Zhang, Y; Zhu, Y	1
Lane, HY; Lin, CH; Yang, HT	1
D'Adamio, L; Tambini, MD; Yao, W	1
Huang, WH; Liu, YL; Qiu, QF; Tang, Y; Wu, WT; Yang, XK; Zhang, FL	1
Brewer, GJ; Glabe, CG; Herrera, RA; Philipp, S; Reyes-Ruiz, JM; Sosna, J	1
Cui, G; Guo, B; Han, Y; Hu, S; Liu, Z; Luo, F; Mak, S; Sun, Y; Wang, J; Wang, Y; Wu, L; Zhang, G; Zhang, Z	1
Binvignat, O; Olloquequi, J	1
Benfeito, S; Borges, F; Fernandes, C; Remião, F; Uriarte, E; Vilar, S	1
Alimirah, F; Campisi, J; Davalos, AR; Desprez, PY; Gan, L; Limbad, C; Oron, TR; Tracy, TE	1
Atiya, S; Bartha, R; Borrie, MJ; Brymer, C; Fogarty, J; Montero-Odasso, M; Pasternak, SH; Wong, D	1
Bie, B; Foss, JF; Naguib, M; Wu, J	1
Kashiwaya, Y; King, MT; Pawlosky, RJ; Veech, RL	1
Ashraf, A; Jeandriens, J; Parkes, HG; So, PW	1
Chang, CH; Lane, HY; Lin, CH	1
Hou, J; Hu, Y; Qu, Z; Ren, M; Wang, C; Yang, G; Zhang, M	1
Clement, JP; Jubie, S; Justin, A; Manisha, C; Moola Joghee Nanjan, C; Moola Joghee, N; Selvaraj, A	1
Dai, Y; Duan, DD; Qin, LX; Wei, JP; Wen, W; Wen, YQ; Xu, SJ	1
Barbar, L; Burstein, SR; Croft, G; di Domenico, A; Fossati, V; Guttenplan, KA; Hébert, JM; Jain, T; Kalpana, K; Kruglikov, I; Liddelow, SA; Nijsure, M; Nobuta, H; Rose, IVL; Rusielewicz, T; Sadick, JS; Wang, M; Zhang, B; Zimmer, M	1
Amoroso, S; Lariccia, V; Magi, S; Maiolino, M; Piccirillo, S	1
Findley, CA; Hascup, ER; Hascup, KN; Sime, LN	1
Billard, JM; Freret, T; Ploux, E	1
Archana, M; Balawender, K; Beggiato, S; Bukke, VN; Cassano, T; Orkisz, S; Romano, AD; Serviddio, G; Villani, R; Wawrzyniak, A	1
Onaolapo, AY; Onaolapo, OJ	1
Chayrov, R; Jiang, H; Li, Y; Li, Z; Liu, R; Mitrev, Y; Perlovich, GL; Stankova, I; Štícha, M; Tencheva, A; Volkova, TV	1
Auladell, C; Beas-Zarate, C; Busquets, O; Camins, A; Castro-Torres, RD; Ettcheto, M; Parcerisas, A; Verdaguer, E	1
Kinney, JW; Leisgang, AM; Murtishaw, AS; Ortiz, AA; Salazar, AM	1
Aldana, BI; Andersen, JV; Christensen, SK; Diaz-delCastillo, M; Schousboe, A; Tanila, H; Waagepetersen, HS; Westi, EW	1
Gulyaeva, NV	1
Igarashi, H; Kakita, A; Kera, T; Kitaura, H; Kwee, IL; Ohkubo, M; Ohno, K; Terumitsu-Tsujita, M; Ueki, S	1
Adeniyi, PA; Adigun, OO; Arietarhire, LO; Arogundade, T; Asogwa, NT; Bamisi, O; Gbadamosi, IT; Idowu, OK; Kareem, R; Lambe, E; Lewu, FS; Ogunrinola, KY; Olajide, OJ; Oluyomi, OO; Yawson, EO	1
Ge, RL; Ji, W; Liu, J; Luo, J; Wan, Y; Zhang, Y	1
Chuchmacz, J; Czarnecka, K; Szymański, P; Wójtowicz, P	1
Altiné-Samey, R; Antier, D; Balageas, AC; Beaufils, E; Chalon, S; Dufour-Rainfray, D; Emond, P; Foucault-Fruchard, L; Mavel, S	1
Pinelis, V; Pomytkin, I	1
Hao, J; Hao, Q; Hou, X; Song, Y; Wang, J; Wang, X	1
Chang, CH; Chen, SJ; Huang, CS; Lane, HY; Lin, CH; Lin, WC; Liu, CY; Yang, HT	1
Calabresi, P; Casamassa, A; Di Maio, A; Donati, G; Errico, F; Gaetani, L; Isidori, A; Mancini, A; Miroballo, M; Nuzzo, T; Paoletti, FP; Parnetti, L; Sansone, G; Usiello, A	1
Aldana, BI; Andersen, JV; Freude, KK; Salcedo, C; Schousboe, A; Vinten, KT; Waagepetersen, HS; Wagner, A	1
Cauli, B; Hérault, K; Li, D; Maldera, S; Oheim, M; Pham, C; Vialou, V	1
Acosta, ML; Araya-Arriagada, J; Bello, F; Chacón, M; Durán-Aniotz, C; Escobar, MJ; Hetz, C; Neira, D; Palacios, AG; Shivashankar, G	1
Ibrahim, FM; Imran, M; Jugreet, S; Keenoo, BS; Lobine, D; Mahomoodally, MF; Sadeer, N; Suroowan, S; Venugopala, KN; Zengin, G	1
Chiu, PW; Herrup, K; Ip, I; Liu, T; Mak, HKF; Song, YQ; Wong, GHY; Wong, SWH; Zhang, H	1
Dejakaisaya, H; Jones, NC; Kwan, P	1
Han, J; Shen, Y; Su, LD; Wang, N	1
Caligiuri, ME	1
Chapman, CA; Olajide, OJ	1
Fan, S; Gao, J; Li, L; Li, W; Liu, L; Xian, X	1
Aldana, BI; Andersen, JV; Jakobsen, E; Markussen, KH; Rosenberg, PA; Schousboe, A; Waagepetersen, HS	1
Geoffroy, C; Mony, L; Paoletti, P	1
Basso, E; Pozzan, T; Rigotto, G; Zentilin, L	1
Benway, TA; Brandner, S; Cummings, DM; Edwards, FA; Fernandes Freitas, MM; Ho, H; Lashley, T; Murray, CE; Richard-Loendt, A; Salih, DA; Shahab, L; Tedoldi, A	1
Binder, DK; Hubbard, JA	1
Gerhardt, GA; Heslin, RT; Hunsberger, HC; Quintero, JE; Reed, MN; Setti, SE	1
Alonso, JF; Baena, A; Duque, JE; Hernández, AM; Lopera, F; Mañanas, MA; Ochoa, JF; Tobón, CA	1
Nikhil, K; Shah, K	1
Agoulnik, AI; Agoulnik, IU; Ahmad, M; Beiras-Fernandez, A; Blessing, F; Bryant, D; Cao, CZ; Cervantes, B; Cho, SK; Davies, BM; Eifert, S; Flaig, TW; Gao, JZ; Guo, L; Harel, R; He, JL; Ho, BA; How, J; Jacobs, D; Jaeger, B; Jaramillo, C; Jiao, JJ; Johnson, AM; Kaftanovskaya, EM; Karthikeyan, A; Kavanagh, B; Kazmi, SAJ; Knoller, N; La Rosa, FG; LeBel, ME; Li, DD; Li, JX; Li, K; Li, T; Liang, F; Litchfield, R; Liu, S; Ma, XX; Marugan, J; Moore, SN; Moro, J; Myhr, C; Nanda, KK; Nandan, R; Niu, H; Oberhoffer, M; Park, W; Parvin, N; Patel, HC; Qi, JS; Qiu, Y; Reichart, B; Rui, R; Schlaepfer, IR; Seidel, D; Sen, SS; Shi, SH; Siemian, JN; Smith, EE; Somerville, LE; Soula, M; Su, LJ; Swamy, VSVSN; Toms, SA; Vanka, K; Vipin Raj, K; Wang, J; Wang, L; Wang, T; Wen, YJ; Willits, K; Wolk, DM; Wu, HH; Yan, Z; Yang, LW; Yang, Q; Yang, X; Yang, Y; Yin, J; Yoo, C; Yuan, L; Zhang, HJ; Zhang, J; Zhang, MS; Zhang, SL; Zhang, Y; Zhang, YQ; Zhi, H; Zhou, M; Zuo, L	1
Gong, QY; Gu, GJ; Guo, Y; Liu, JH; Wang, MY; Xu, JR; Zhang, B; Zhang, Q; Zhang, W	1
Chen, Q; Digiacomo, M; Nesi, G; Pi, R; Rapposelli, S; Sestito, S; Wang, S; Yang, X	1
Arias-Londoño, JD; Barrera-Ocampo, A; Cardona-Gómez, GP; Lopera, F; Villamil-Ortiz, JG; Villegas, A	1
Davydova, TV; Gruden, MA; Kudrin, VS; Morozova-Roche, LA; Narkevich, VB; Sewell, RDE; Wang, C	1
Bertoli, A; Sorgato, MC	1
Beer-Hammer, S; Danielyan, L; Hunanyan, L; Layer, N; Lourhmati, A; Melkonyan, MM; Schwab, M; Yenkoyan, K	1
Daumas, S; Davoli, MA; El Mestikawy, S; Epelbaum, J; Haroutunian, V; Herzog, E; Katsel, P; Mechawar, N; Mella, S; Poirel, O; Ramet, L; Videau, C	1
Jose, J; Lakhotia, SC; Patel, AB; Saba, K; Tiwari, V; Veeraiah, P	1
Geerts, H; Roberts, P; Spiros, A	1
Klivényi, P; Szalárdy, L; Vécsei, L; Veres, G; Zádori, D	1
Abe, Y; Maruyama, T; Niikura, T; Wada, H	1
Benarroch, EE	1
Joe, E; Medina, LD; O'Neill, J; Ringman, JM	1
Alghamdi, BSA	1
Cui, SY; Cui, XY; Ding, H; Ge, YR; Hu, X; Luo, Y; Ma, YN; Shi, YT; Song, JZ; Ye, H; Zhang, YH	1
Dolly, JO; Ntziachristos, V; O'Leary, VB; Ovsepian, SV; Zaborszky, L	1
Du, M; He, J; Hu, X; Kou, L; Sun, X; Teng, S; Wang, X	1
Cardona-Gómez, GP; Villamil-Ortiz, JG	1
Doig, AJ	1
Fan, S; Hu, Y; Li, L; Li, W; Xian, X; Yao, X; Zhang, M	1
Bartke, A; Boger, HA; Broderick, SO; Fang, Y; Hascup, ER; Hascup, KN; Russell, MK	1
Cha, MY; Jang, Y; Jeon, SG; Jung, ES; Kim, KS; Kim, W; Lopes, C; Mook-Jung, I; Moon, M	1
Cai, X; Chen, X; Hu, W; Kong, F; Li, Z; Wang, C; Wang, D	1
Canonico, PL; Chisari, M; Conte, E; Genazzani, AA; Grilli, M; Lim, D; Manfredi, M; Marengo, E; Rocchio, F; Ronco, F; Ruffinatti, FA; Sortino, MA; Tapella, L	1
Bowdler, P; Conway, ME; Coulthard, E; Harris, M; Hudd, F; Kauppinen, R; Knight, M; McCann, B; Shiel, A; Tsivos, D; Wearn, A; White, P	1
Chrienova, Z; Hepnarova, V; Holubova, K; Horak, M; Kaniakova, M; Kleteckova, L; Kobrlova, T; Korabecny, J; Kucera, T; Nepovimova, E; Skrenkova, K; Soukup, O; Vales, K	1
Arnold, DB; Bayer, KU; Cook, SG; Goodell, DJ; Restrepo, S	1
D'Adamio, L; Liu, X; Tambini, MD; Yao, W	1
Davydova, TV; Fomina, VG; Gorbatov, VY; Kolobov, VV; Zakharova, IA	1
Cook, DG; Diamond, JS; Meabon, JS; Scimemi, A; Sullivan, JM; Woltjer, RL	1
Bal, W; Barnham, KJ; Drew, SC; Kenche, VB; Masters, CL; Zawisza, I	1
Belli, L; Bianconi, C; Esposito, Z; Martorana, A; Sancesario, G; Toniolo, S	1
Akhtar, MW; Ambasudhan, R; Buczynski, MW; Cao, G; Chen, HS; Dziewczapolski, G; Fang-Newmeyer, T; Heinemann, SF; Hires, SA; Holland, EA; Kang, YJ; Kelly, JW; Lipton, SA; Masliah, E; McKercher, SR; Michael, S; Molokanova, E; Nakamura, T; Nakanishi, N; Okamoto, S; Parker, J; Parsons, LH; Piña-Crespo, JC; Powers, ET; Pratt, AE; Roberts, A; Sanz-Blasco, S; Sason, H; Solomon, JP; Stouffer, DG; Talantova, M; Tong, G; Tu, S; Wang, Y; Wolosker, H; Xia, P; Zhang, D; Zhang, X	1
Cheong, YH; Jo, SA; Kim, H; Kim, MJ; Lee, SK; Park, SI; Youn, HS	1
Wang, X; Xu, L	1
Annweiler, C; Bartha, R; Beauchet, O; Brugg, B; Peyrin, JM	1
Ataeijannati, Y; Ball, KA; Head-Gordon, T; Lu, H; Park, H; Poo, MM; Schaffer, DV; Vazin, T	1
Chvátal, A; Kulijewicz-Nawrot, M; Rodríguez, JJ; Syková, E; Verkhratsky, A	1
Kluijtmans, LA; Metaxas, A; Timmer, NM; van Berckel, BN; van der Stelt, I; Verbeek, MM	1
Balayssac, S; Déjean, S; Francés, B; Gilard, V; Halley, H; Lalande, J; Lassalle, JM; Malet-Martino, M; Martino, R	1
Aytan, N; Carreras, I; Choi, JK; Dedeoglu, A; Jenkins, BG; Kowall, NW; McKee, AC	1
Cadenas, E; Díaz Brinton, R; Kanamori, K; Patil, I; Ross, BD; Sancheti, H	1
Baek, SH; Jo, DG; Jung, WR; Kim, HG; Kim, KL; Park, DI; Park, JS; Shin, MK	1
Biegon, A; Gaisler-Salomon, I; Kravitz, E	1
Awni, A; Codadu, NK; Dineley, KT; Hill, EJ; Nagel, DA; Parri, HR; Pirttimaki, TM; Pratik, P	1
Majláth, Z; Toldi, J; Vécsei, L	1
Buisson, A; Rush, T	1
Chen, M; Nguyen, HT	1
Antonelli, T; Beggiato, S; Calzà, L; Ferraro, L; Giardino, L; Giuliani, A; Imbimbo, BP; Lorenzini, L; Sivilia, S	1
Chen, J; Chen, X; Fang, Y; Hou, L; Huang, G; Liu, S; Luo, X; Mu, N; Ning, Y; Shen, Z; Shi, H; Tan, Y; Wu, R; Zhang, H; Zhang, Y; Zheng, D; Zhong, X	1
Alzweiri, M; Bardaweel, SK; Ishaqat, AA	1
Nilsen, LH; Sonnewald, U; Witter, MP	1
Ari, C; Borysov, SI; Padmanabhan, J; Potter, H; Wu, J	1
Adame, A; Campioni, S; Gage, FH; Gerez, J; Jensen, PH; Mante, M; Masliah, E; Nuber, S; Overk, CR; Patrick, C; Picotti, P; Riek, R; Rockenstein, E; Trejo-Morales, M; Ubhi, K; Winkler, J; Winner, B	1
Klivényi, P; Szalárdy, L; Toldi, J; Vécsei, L; Veres, G; Zádori, D	1
Chen, SD; Deng, YL; Huang, FJ; Jia, W; Liu, JJ; Ma, JF; Ren, RJ; Tang, HD; Wang, G; Wang, Y; Xu, W; Xu, XH; Zhang, YN; Zhao, AH; Zhou, Y	1
Chen, B; Goldblatt, G; Jeon, J; Matos, JO; Tatulian, SA	1
Boksha, IS; Burbaeva, GSh; Prokhorova, TA; Savushkina, OK; Tereshkina, EB; Vorobyeva, EA	1
Hascup, ER; Hascup, KN	1
Fang, Y; Fung, CK; Iu, CY; Lai, KW; Li, HW; Lui, CN; Xi, N; Yung, KK; Zou, Y	1
Atwal, JK; Behrens, TW; Bhangale, TR; Cruchaga, C; Farrer, LA; Foreman, O; Goate, A; Graham, RR; Haines, J; Hansen, DV; Hunkapiller, J; Maloney, JA; Mayeux, R; Ortmann, W; Pericak-Vance, M; Rathore, N; Sa, SM; Schellenberg, GD; Srinivasan, K; Tessier-Lavigne, M; Watts, RJ; Wetzel-Smith, MK; Yaylaoglu, MB	1
Baqi, Y; Batalha, VL; Blum, D; Buée, L; Burnouf, S; Coelho, JE; D'Hooge, R; Faivre, E; Ferry, B; Flaten, V; Hamdane, M; Humez, S; Laurent, C; Ledent, C; Lopes, LV; Malik, E; Mariciniak, E; Müller, CE; Parrot, S; Sergeant, N; Van der Jeugd, A	1
Esmaeili Tazangi, P; Haghani, M; Moosavi, SM; Shabani, M	1
Doert, A; Eckert, GP; Müller, WE; Pilatus, U; Zanella, F	1
Antonelli, T; Beggiato, S; Borelli, AC; Cassano, T; Ferraro, L; Tanganelli, S; Tomasini, MC	1
Ellis, B; Hye, A; Snowden, SG	1
Coulter, DA; Dulla, CG; Ziburkus, J	1
Cheng, D; Hawkins, C; Kieu, Z; Kilian, J; Kitazawa, M; Lim, SL; Medeiros, R; Rodriguez-Ortiz, CJ; Wai, T; Zumkehr, J	1
Dezsi, L; Martos, D; Tuka, B; Vecsei, L	1
Bali, J; Birnbaum, JH; Nitsch, RM; Rajendran, L; Tackenberg, C	1
Gerhardt, GA; Hickman, JE; Hunsberger, HC; Libell, EM; Reed, MN; Rudy, CC; Speer, RR; Weitzner, DS	1
Choi, C; Cui, W; Han, Y; Hu, S; Hu, Y; Lee, M; Mak, S; Pang, Y; Tang, J; Xu, D	1
Furukawa-Hibi, Y; Hattori, H; Hibi, H; Mita, T; Takeuchi, H; Ueda, M; Yamada, K; Yamamoto, A	1
Cong, L; Du, H; Du, Y; Han, X; Li, S; Liu, X; Sun, Q; Wang, X; Yang, L; Yin, L	1
Akishita, M; Ogawa, S; Ota, H; Ouchi, Y	1
Hickman, JE; Hunsberger, HC; Reed, MN	1
Abbas, G; Kabir, N; Mahmood, W	1
Elkahloun, AG; Hafko, R; Saavedra, JM	1
Brunavs, M; Burris, KD; Cerne, R; Chase, P; Cuadrado, M; Findlay, J; Gallagher, P; Jambrina, E; Krambis, MJ; Scampavia, L; Smith, E; Spicer, TP; Ursu, D; Wakulchik, M	1
Akai, T; Iizuka, H; Ishigaki, Y; Kato, N; Liu, X; Shui, Y; Tajima, N; Uchiumi, O; Wang, M; Zou, J	1
Davidson, RL; Gray, JD; Kogan, JF; McEwen, BS; Morrison, JH; Okamoto, M; Pereira, AC; Rubin, TG	1
Choe, BY; Jahng, GH; Kim, HG; Lee, DW; Lee, KM; Oh, J; Paik, JW; Park, S; Rhee, HY; Ryu, CW; Shin, W	1
Ding, Y; Fitz, NF; Garver, ME; Ikonomovic, MD; Jones-Laughner, J; Kirkwood, CM; Kofler, J; Koldamova, R; Lopez, OL; MacDonald, ML; Schempf, T; Sweet, RA; Yates, NA	1
Gerenu, G; Gil-Bea, FJ; Ramirez, MJ; Rodriguez-Perdigon, M; Solas, M; Tordera, RM	1
Dutta, S; Foley, AR; Raskatov, JA; Warner, CJ	1
Haas, LT; Strittmatter, SM	1
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Farber, NB; Newcomer, JW; Olney, JW	1
Beckstrøm, H; Danbolt, NC; Dewar, D; Graham, DI; Haugeto, O; Julsrud, L; Lehre, KP; Storm-Mathisen, J	1
Bauer, J; Eistetter, J; Fiebich, BL; Hüll, M	1
Glazner, GW; Guo, Q; Martin, GM; Mattson, MP; Miller, MW; Sebastian, L; Sopher, BL; Ware, CB	1
Masliah, E; Thorns, V	1
Aisen, PS; Mukherjee, P; Osaka, H; Pasinetti, GM	1
Casamenti, F; Colivicchi, MA; Faussone-Pellegrini, MS; Giovannelli, L; Pepeu, G; Prosperi, C; Scali, C	1
Geiger, JD; Guo, ZH; Mattson, MP	1
Cuzner, ML; Kingham, PJ; Pocock, JM	1
Barrow, CJ; He, W	1
Cecchi, C; Favilli, F; Iantomasi, T; Latorraca, S; Liguri, G; Sorbi, S; Vincenzini, MT	1
Butterfield, DA; Carney, JM; Harris-White, ME; Lauderback, CM; Pedigo, NW; Wang, Y	1
Amin, N; Francis, PT; Pearce, B; Webster, MT	1
Barger, SW; Griffin, WS; Kang, J; Li, Y; Liu, L; Mrak, RE; Sheng, JG	1
Dave, KR; Katyare, SS; Swegert, CV	1
Shoffner, JM	1
Friedlander, RM; Kwon, YT; Lee, MS; Li, M; Peng, J; Tsai, LH	1
Bergmans, PL; Kuiper, MA; Scheltens, P; Teerlink, T; Visser, JJ; Wolters, EC	1
Atwood, CS; Bush, AI; Huang, X; Khatri, A; Kim, YS; Moir, RD; Roher, AE; Scarpa, RC; Tanzi, RE	1
Abrahám, I; Harkany, T; Kónya, C; Korf, J; Laskay, G; Luiten, PG; Nyakas, C; Penke, B; Sasvári, M; Sebens, JB; Soós, K; Timmerman, W; Tóth, B; Zarándi, M	1
Akahane, A; Hirasawa, H; Isse, K; Kato, N; Kobayashi, S; Kunugi, H; Nabika, T; Nanko, S; Otsuka, M; Ueki, A	1
Lovell, MA; Markesbery, WR; Xie, C	1
Flood, DG; Lin, YG; Reaume, AG; Savage, MJ; Scott, RW; Siman, R; Trusko, S	1
Ross, BD	1
Cairns, N; Kaehler, ST; Lubec, G; Seidl, R; Singewald, N	1
Bondada, S; Culmsee, C; Mattson, MP	1
Antuono, PG; Jones, JL; Li, SJ; Wang, Y	1
Alvarez-Arcaya, A; Berciano, J; Combarros, O; González-García, J; Llorca, J; Mateo, I; Sánchez-Guerra, M	1
Akaike, A; Honda, K; Kihara, T; Nakamizo, T; Sawada, H; Shibasaki, H; Shimohama, S	1
Adamchik, Y; Baskys, A	1
Culmsee, C; Haughey, NJ; Herman, JP; Mattson, MP; McCullers, D; Pedersen, WA	1
Hattori, N; Inagaki, C; Irie, T; Kitagawa, K; Wu, B; Yagyu, K; Zeng, XT	1
Cagiano, R; Cassano, T; Cuomo, V; Kendrick, KM; Pietra, C; Steardo, L; Tattoli, M; Trabace, L	1
Aosaki, T; Miura, M; Nakajima, M; Shirasawa, T	1
Aliprandi, A; De Micheli, A; Dolara, A; Ferrarese, C; Frattola, L; Stanzani, L; Tremolizzo, L	1
Robinson, SR	1
Chen, XQ; Hu, GY; Wang, Y; Yang, HH; Zhang, YH; Zhao, XY	1
Abe, K; Hattori, N; Sakoda, S; Sawada, T	1
Li, R; Liang, Z; Rogers, J; Sefidvash-Hockley, S; Valla, J	1
Birrell, JM; Blackwell, AD; Bolton, C; Chipperfield, RS; Dening, TR; Sahakian, BJ; Vesey, R	1
Dodd, PR; Lewis, RJ; Mortensen, M; Ragnarsson, L	1
Davis, KL; Lawlor, BA	1
Kuncl, RW; Martin, LJ; Rothstein, JD	1
Beal, MF	1
Barthe, D; Couratier, P; Hugon, J; Sindou, P	1
Klunk, WE; McClure, RJ; Moossy, J; Panchalingam, K; Pettegrew, JW	1
Couratier, P; Delacourte, A; Hugon, J; Sautière, PE; Sindou, P; Wattez, A	1
Bowen, D; Cross, A; Francis, P; Sims, N	1
Hardy, J	1
Bertolucci, PH; Bowen, DM; Francis, PT; Lowe, SL; Procter, AW; Stratmann, GC	1
Beal, MF; Kowall, NW	1
Frangione, B; Ghiso, J; Wisniewski, T	1
Bowen, DM; Lowe, SL; Palmer, AM; Steele, JE	1
Fujiwara, M; Fukunaga, R; Kameyama, M; Ninomiya, H; Shimohama, S; Taniguchi, T	1
Bowen, DM; Lowe, SL	1
Bowen, DM	1
Bowen, DM; Francis, PT; Lowe, SL; Neary, D	1
Chalmers, DT; Dewar, D; Graham, DI; McCulloch, J; Shand, A	1
Bowen, DM; Francis, PT; Lowe, SL; Pangalos, MN; Procter, AW; Steele, JE	1
Olney, JW	1
Barnes, DM	1
Damasio, AR; Hyman, BT; Van Hoesen, GW	1
Bowen, DM; Lowe, SL; Procter, AW; Stratmann, GC; Wong, EH	1
Bowen, DM; Cross, AJ; Procter, AW; Stirling, JM; Stratmann, GC	1
Vamvakides, A	1
Meldrum, B	1
D'Amato, CJ; Greenamyre, JT; Hicks, SP; Penney, JB; Shoulson, I; Young, AB	1
Bowen, DM; Francis, PT; Neary, D; Smith, CC; Snowden, JS	1
De Boni, U; McLachlan, DR	1
Davison, AN	1
Arai, H; Iizuka, R; Kanazawa, I; Kosaka, K; Muramoto, O; Sasaki, H	1
Harrison, PJ	1
Cotman, CW; Geddes, JW	1
Beal, MF; Bird, ED; Ellison, DW; Martin, JB; Mazurek, MF	1
D'Amato, CJ; Greenamyre, JT; Penney, JB; Young, AB	1
Casamenti, F; Cosi, C; Pedata, F; Pepeu, G; Pepeu, IM	1
Chang-Chui, H; Cooper, SM; Cotman, CW; Geddes, JW; Lott, IT	1
Barton, A; Cowburn, R; Hardy, J; Lofdahl, E; O'Carroll, AM; Reynolds, G; Wester, P; Winblad, B	1
Bowen, DM; Carl, R; Francis, PT; Lowe, SL; Neal, JW; Pearson, A; Powell, TP; Stephens, PH	1
Ishihara, T; Kaśe, Y; Nakagawa, Y; Nakamura, S; Noguchi, T	1
Bowen, DM; Murphy, E; Neary, D; Palmer, AM; Procter, AW	1
Briggs, R; Cowburn, R; Hardy, J; Roberts, P	2
Albin, RL; Greenamyre, JT; Maragos, WF; Penney, JB; Young, AB	1
Ben-Ari, Y; Duyckaerts, C; Hauw, JJ; Represa, A; Tremblay, E	2

Reviews

117 review(s) available for glutamic acid and Acute Confusional Senile Dementia

Article	Year
Glutamate Metabolism in Mitochondria is Closely Related to Alzheimer's Disease. Journal of Alzheimer's disease : JAD, 2021, Volume: 84, Issue:2 Topics: Alzheimer Disease; Biological Transport; Brain; Glutamic Acid; Homeostasis; Humans; Mitochondria	2021
Glutamate and GABA in Microglia-Neuron Cross-Talk in Alzheimer's Disease. International journal of molecular sciences, 2021, Oct-28, Volume: 22, Issue:21 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Microglia; Neuroinflammatory Diseases; Neurons; Receptor Cross-Talk	2021
Impairments of glutamatergic synaptic transmission in Alzheimer's disease. Seminars in cell & developmental biology, 2023, Volume: 139 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Glutamic Acid; Humans; Neurons; Synapses; Synaptic Transmission	2023
Bioactive human Alzheimer brain soluble Aβ: pathophysiology and therapeutic opportunities. Molecular psychiatry, 2022, Volume: 27, Issue:8 Topics: Alzheimer Disease; Amyloid beta-Peptides; Brain; Glutamic Acid; Humans; Long-Term Potentiation; Receptors, N-Methyl-D-Aspartate	2022
WNT/β-catenin Pathway: a Possible Link Between Hypertension and Alzheimer's Disease. Current hypertension reports, 2022, Volume: 24, Issue:10 Topics: Aged; Alzheimer Disease; beta Catenin; Essential Hypertension; Glutamic Acid; Humans; Hypertension; Wnt Signaling Pathway	2022
Astrocyte energy and neurotransmitter metabolism in Alzheimer's disease: Integration of the glutamate/GABA-glutamine cycle. Progress in neurobiology, 2022, Volume: 217 Topics: Alzheimer Disease; Astrocytes; Energy Metabolism; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Neurotransmitter Agents	2022
Astrocytic MicroRNAs and Transcription Factors in Alzheimer's Disease and Therapeutic Interventions. Cells, 2022, 12-17, Volume: 11, Issue:24 Topics: Alzheimer Disease; Astrocytes; Cholesterol; Glutamic Acid; Humans; MicroRNAs; Transcription Factors	2022
Glial Glutamate Transporter-Mediated Plasticity: System x Frontiers in bioscience (Landmark edition), 2023, 03-20, Volume: 28, Issue:3 Topics: Alzheimer Disease; Amino Acid Transport System X-AG; Amino Acid Transport System y+; Amyotrophic Lateral Sclerosis; Antioxidants; Cystine; Glioma; Glutamic Acid; Humans; Microglia; Multiple Sclerosis; Parkinson Disease	2023
Pathogenesis of Alzheimer's Disease and Diversity of 1,2,3-Triazole Scaffold in Drug Development: Design Strategies, Structural Insights, and Therapeutic Potential. ACS chemical neuroscience, 2023, 09-20, Volume: 14, Issue:18 Topics: Alzheimer Disease; Amyloidogenic Proteins; Calcium; Glutamic Acid; Humans; Triazoles	2023
Glutamate Receptor Dysregulation and Platelet Glutamate Dynamics in Alzheimer's and Parkinson's Diseases: Insights into Current Medications. Biomolecules, 2023, Nov-03, Volume: 13, Issue:11 Topics: Alzheimer Disease; Animals; Glutamic Acid; Humans; Parkinson Disease; Receptors, Glutamate	2023
Excitotoxicity as a Target Against Neurodegenerative Processes. Current pharmaceutical design, 2020, Volume: 26, Issue:12 Topics: Alzheimer Disease; Glutamic Acid; Humans; Memantine; Neurons	2020
d-glutamate and Gut Microbiota in Alzheimer's Disease. International journal of molecular sciences, 2020, Apr-11, Volume: 21, Issue:8 Topics: Alzheimer Disease; Animals; Blood-Brain Barrier; Brain; Diet; Disease Susceptibility; Gastrointestinal Microbiome; Glutamic Acid; Humans; Metabolic Networks and Pathways; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Synaptic Transmission	2020
d-serine in physiological and pathological brain aging. Biochimica et biophysica acta. Proteins and proteomics, 2021, Volume: 1869, Issue:1 Topics: Aging; Alzheimer Disease; Animals; Astrocytes; Cognition; Gene Expression; Glucose; Glutamic Acid; Hippocampus; Humans; Memory; Neuronal Plasticity; Neurons; Racemases and Epimerases; Receptors, N-Methyl-D-Aspartate; Serine	2021
The Dual Role of Glutamatergic Neurotransmission in Alzheimer's Disease: From Pathophysiology to Pharmacotherapy. International journal of molecular sciences, 2020, Oct-09, Volume: 21, Issue:20 Topics: Alzheimer Disease; Animals; Biomarkers; Disease Management; Disease Susceptibility; Glucose; Glutamic Acid; Humans; Molecular Targeted Therapy; Neurons; Receptors, Ionotropic Glutamate; Synaptic Transmission	2020
c-Jun N-Terminal Kinases in Alzheimer's Disease: A Possible Target for the Modulation of the Earliest Alterations. Journal of Alzheimer's disease : JAD, 2021, Volume: 82, Issue:s1 Topics: Alzheimer Disease; Animals; Brain-Derived Neurotrophic Factor; Drug Delivery Systems; gamma-Aminobutyric Acid; Glutamic Acid; Humans; JNK Mitogen-Activated Protein Kinases; Nerve Growth Factor; Neurons; Protein Kinase Inhibitors; Synapses	2021
Memantine in neurological disorders - schizophrenia and depression. Journal of molecular medicine (Berlin, Germany), 2021, Volume: 99, Issue:3 Topics: Alzheimer Disease; Antidepressive Agents; Antipsychotic Agents; Clinical Trials as Topic; Depression; Drug Repositioning; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Memantine; N-Methylaspartate; Neuronal Plasticity; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Serotonin 5-HT3 Receptor Antagonists	2021
The contributions of metabolomics in the discovery of new therapeutic targets in Alzheimer's disease. Fundamental & clinical pharmacology, 2021, Volume: 35, Issue:3 Topics: Alanine; Alzheimer Disease; Animals; Arginine; Aspartic Acid; Biomarkers; Disease Models, Animal; Glutamic Acid; Humans; Metabolomics; Rats	2021
Potential of Medicinal Plants as Neuroprotective and Therapeutic Properties Against Amyloid-β-Related Toxicity, and Glutamate-Induced Excitotoxicity in Human Neural Cells. Current neuropharmacology, 2021, Volume: 19, Issue:9 Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Glutamic Acid; Humans; Parkinson Disease; Plants, Medicinal	2021
Astrocyte and glutamate involvement in the pathogenesis of epilepsy in Alzheimer's disease. Epilepsia, 2021, Volume: 62, Issue:7 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Astrocytes; Encephalitis; Epilepsy; Glutamic Acid; Humans; Middle Aged	2021
Group 1 Metabotropic Glutamate Receptors in Neurological and Psychiatric Diseases: Mechanisms and Prospective. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 2022, Volume: 28, Issue:5 Topics: Alzheimer Disease; Autism Spectrum Disorder; Glutamic Acid; Humans; Mental Disorders; Parkinson Disease	2022
Glutamate metabolism and recycling at the excitatory synapse in health and neurodegeneration. Neuropharmacology, 2021, 09-15, Volume: 196 Topics: Alzheimer Disease; Animals; Astrocytes; Energy Metabolism; Glutamic Acid; Homeostasis; Humans; Huntington Disease; Neurodegenerative Diseases; Neurons; Synapses	2021
Positive allosteric modulation of NMDA receptors: mechanisms, physiological impact and therapeutic potential. The Journal of physiology, 2022, Volume: 600, Issue:2 Topics: Allosteric Regulation; Alzheimer Disease; Animals; Glutamic Acid; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission	2022
Alzheimer's Disease: Recent Concepts on the Relation of Mitochondrial Disturbances, Excitotoxicity, Neuroinflammation, and Kynurenines. Journal of Alzheimer's disease : JAD, 2018, Volume: 62, Issue:2 Topics: Alzheimer Disease; Animals; Central Nervous System; Disease Models, Animal; Energy Metabolism; Glutamic Acid; Humans; Immunity, Innate; Inflammation; Kynurenine; Mitochondria; Quinolinic Acid; Reactive Oxygen Species; Receptors, Glutamate; Signal Transduction	2018
Glutamatergic synaptic plasticity and dysfunction in Alzheimer disease: Emerging mechanisms. Neurology, 2018, 07-17, Volume: 91, Issue:3 Topics: Alzheimer Disease; Animals; Astrocytes; Glutamic Acid; Humans; Neuronal Plasticity; Synapses; Synaptic Transmission	2018
Amyloid Plaques of Alzheimer's Disease as Hotspots of Glutamatergic Activity. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 2019, Volume: 25, Issue:4 Topics: Alzheimer Disease; Animals; Axons; Brain; Glutamic Acid; Humans; Plaque, Amyloid; Presynaptic Terminals	2019
Positive Feedback Loops in Alzheimer's Disease: The Alzheimer's Feedback Hypothesis. Journal of Alzheimer's disease : JAD, 2018, Volume: 66, Issue:1 Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Feedback, Physiological; Glutamic Acid; Humans; Oxidative Stress; tau Proteins	2018
Amyloid β, glutamate, excitotoxicity in Alzheimer's disease: are we on the right track? CNS neuroscience & therapeutics, 2013, Volume: 19, Issue:8 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cholinesterase Inhibitors; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Receptors, N-Methyl-D-Aspartate	2013
The potential role of kynurenines in Alzheimer's disease: pathomechanism and therapeutic possibilities by influencing the glutamate receptors. Journal of neural transmission (Vienna, Austria : 1996), 2014, Volume: 121, Issue:8 Topics: Alzheimer Disease; Animals; Glutamic Acid; Humans; Kynurenine; Neuroprotective Agents; Receptors, Glutamate; Signal Transduction	2014
Reciprocal disruption of neuronal signaling and Aβ production mediated by extrasynaptic NMDA receptors: a downward spiral. Cell and tissue research, 2014, Volume: 356, Issue:2 Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Calcium Signaling; Cell Survival; Dopamine Agents; Glutamic Acid; Humans; Memantine; Receptors, N-Methyl-D-Aspartate	2014
D-Serine in neurobiology: CNS neurotransmission and neuromodulation. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 2014, Volume: 41, Issue:2 Topics: Alzheimer Disease; Amyotrophic Lateral Sclerosis; Animals; Central Nervous System; Epilepsy; Glutamic Acid; Humans; Hypoxia-Ischemia, Brain; Mental Disorders; Neurodegenerative Diseases; Neuronal Plasticity; Neurotransmitter Agents; Receptors, N-Methyl-D-Aspartate; Serine; Synaptic Transmission	2014
Glutamatergic dysfunctioning in Alzheimer's disease and related therapeutic targets. Journal of Alzheimer's disease : JAD, 2014, Volume: 42 Suppl 3 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Memantine; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission	2014
Metabolic Modifications in Human Biofluids Suggest the Involvement of Sphingolipid, Antioxidant, and Glutamate Metabolism in Alzheimer's Disease Pathogenesis. Journal of Alzheimer's disease : JAD, 2015, Volume: 46, Issue:2 Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Brain; Glutamic Acid; Humans; Oxidative Stress; Sphingolipids	2015
From Molecular Circuit Dysfunction to Disease: Case Studies in Epilepsy, Traumatic Brain Injury, and Alzheimer's Disease. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 2016, Volume: 22, Issue:3 Topics: Alzheimer Disease; Animals; Brain; Brain Injuries, Traumatic; Cerebral Cortex; Epilepsy; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Humans; Ion Channels; Neural Pathways; Neurons; tau Proteins; Thalamus; TOR Serine-Threonine Kinases	2016
Alzheimer's disease, astrocytes and kynurenines. Current Alzheimer research, 2015, Volume: 12, Issue:5 Topics: Alzheimer Disease; Animals; Astrocytes; Brain; Glutamic Acid; Humans; Kynurenine	2015
Recent progress on the role of GABAergic neurotransmission in the pathogenesis of Alzheimer's disease. Reviews in the neurosciences, 2016, 06-01, Volume: 27, Issue:4 Topics: Alzheimer Disease; Animals; Brain; Glutamic Acid; Humans; Neurogenesis; Neurons; Synaptic Transmission	2016
The pertussis hypothesis: Bordetella pertussis colonization in the pathogenesis of Alzheimer's disease. Immunobiology, 2017, Volume: 222, Issue:2 Topics: Alzheimer Disease; Amyloid beta-Peptides; Biomarkers; Bordetella pertussis; Genetic Predisposition to Disease; Glutamic Acid; Humans; Incidence; Nasopharynx; Neurons; Oxidative Stress; Pertussis Toxin; Pertussis Vaccine; Whooping Cough; Wnt Signaling Pathway	2017
Glutamate and neurotrophic factors in neuronal plasticity and disease. Annals of the New York Academy of Sciences, 2008, Volume: 1144 Topics: Alzheimer Disease; Animals; Brain Diseases; Brain-Derived Neurotrophic Factor; Glutamic Acid; Humans; Nerve Growth Factors; Neurites; Neurogenesis; Neuronal Plasticity; Neurons; Parkinson Disease; Receptors, Glutamate; Receptors, Nerve Growth Factor; Signal Transduction; Stroke	2008
Novel anti-Alzheimer's dimer Bis(7)-cognitin: cellular and molecular mechanisms of neuroprotection through multiple targets. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2009, Volume: 6, Issue:1 Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Apoptosis; Calcium Channels, L-Type; Cholinesterase Inhibitors; Drug Design; Glutamic Acid; Hippocampus; Humans; Long-Term Potentiation; Neurons; Neuroprotective Agents; Nitric Oxide Synthase; Receptors, N-Methyl-D-Aspartate; Tacrine	2009
Synaptic retrogenesis and amyloid-beta in Alzheimer's disease. Journal of Alzheimer's disease : JAD, 2009, Volume: 16, Issue:1 Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Cell Proliferation; Glutamic Acid; Humans; Long-Term Potentiation; Memory; Neuronal Plasticity; Synapses	2009
Molecular mechanisms of excitotoxicity and their relevance to pathogenesis of neurodegenerative diseases. Acta pharmacologica Sinica, 2009, Volume: 30, Issue:4 Topics: Alzheimer Disease; Animals; Apoptosis; Autophagy; Calcium; Chlorides; Glutamic Acid; Humans; Huntington Disease; Neurodegenerative Diseases; Nitric Oxide; Oxidative Stress; Reactive Oxygen Species; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate	2009
Activated astroglia during chronic inflammation in Alzheimer's disease--do they neglect their neurosupportive roles? Mutation research, 2010, Aug-07, Volume: 690, Issue:1-2 Topics: Alzheimer Disease; Antioxidants; Astrocytes; Cytokines; Drug Delivery Systems; Glutamic Acid; Glutathione; Humans; Inflammation; Models, Neurological; Oxidative Stress	2010
Alzheimer's disease amyloid beta-protein and synaptic function. Neuromolecular medicine, 2010, Volume: 12, Issue:1 Topics: Acetylcholine; Alzheimer Disease; Amyloid beta-Peptides; Animals; Glutamic Acid; Humans; Long-Term Potentiation; Long-Term Synaptic Depression; Receptors, Cholinergic; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission	2010
Fragile X Syndrome and Alzheimer's Disease: Another story about APP and beta-amyloid. Current Alzheimer research, 2010, Volume: 7, Issue:3 Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Disease Models, Animal; Excitatory Amino Acid Antagonists; Fragile X Mental Retardation Protein; Fragile X Syndrome; Glutamic Acid; Humans; Phenotype; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate	2010
Novel therapeutics for Alzheimer's disease: an update. Current opinion in drug discovery & development, 2010, Volume: 13, Issue:2 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antibodies; Antioxidants; Enzyme Inhibitors; Glutamic Acid; Humans; Luteinizing Hormone; Mitochondria; tau Proteins	2010
The putative neurodegenerative links between depression and Alzheimer's disease. Progress in neurobiology, 2010, Volume: 91, Issue:4 Topics: Acetylcholine; Alzheimer Disease; Animals; Depression; Glutamic Acid; Humans; Nerve Degeneration; Neurons	2010
Homeostatic disinhibition in the aging brain and Alzheimer's disease. Journal of Alzheimer's disease : JAD, 2011, Volume: 24, Issue:1 Topics: Aging; Alzheimer Disease; Animals; Brain; Glutamic Acid; Homeostasis; Humans; Neural Inhibition; Synaptic Transmission	2011
Meta-analysis of aldehyde dehydrogenase 2 gene polymorphism and Alzheimer's disease in East Asians. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 2011, Volume: 38, Issue:3 Topics: Aged; Aged, 80 and over; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Alzheimer Disease; Apolipoprotein E4; Asia, Eastern; Confidence Intervals; Databases, Bibliographic; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Glutamic Acid; Humans; Lysine; Male; Odds Ratio; Polymorphism, Single Nucleotide	2011
Late-life depression and Alzheimer's disease: the glutamatergic system inside of this mirror relationship. Brain research reviews, 2011, Jun-24, Volume: 67, Issue:1-2 Topics: Aged; Aging; Alzheimer Disease; Animals; Comorbidity; Depressive Disorder; Glutamic Acid; Humans	2011
13C MRS studies of neuroenergetics and neurotransmitter cycling in humans. NMR in biomedicine, 2011, Volume: 24, Issue:8 Topics: Aging; Alzheimer Disease; Animals; Brain; Carbon Isotopes; Citric Acid Cycle; Energy Metabolism; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Neurons; Neurotransmitter Agents	2011
The role of mitochondrial function in glutamate-dependent metabolism in neuronal cells. Current pharmaceutical design, 2011, Volume: 17, Issue:35 Topics: Alzheimer Disease; Animals; Autophagy; Calcium Signaling; Energy Metabolism; Excitatory Amino Acid Agents; Glutamic Acid; Humans; Huntington Disease; Mitochondria; Neuroglia; Neuronal Plasticity; Neurons; Neurotoxicity Syndromes; Parkinson Disease; Synaptic Transmission	2011
Possibility of a new anti-alzheimer's disease pharmaceutical composition combining memantine and vitamin D. Drugs & aging, 2012, Feb-01, Volume: 29, Issue:2 Topics: Alzheimer Disease; Animals; Drug Combinations; Glutamic Acid; Humans; Memantine; Neuroprotective Agents; Vitamin D	2012
Synaptic dysfunction in Alzheimer's disease. Advances in experimental medicine and biology, 2012, Volume: 970 Topics: Acetylcholine; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Cognition; Glutamic Acid; Humans; Mice; Neuronal Plasticity; Polymerization; Protein Binding; Rats; Receptors, Cholinergic; Receptors, Glutamate; Synapses; Synaptic Transmission	2012
Role of phosphoinositides at the neuronal synapse. Sub-cellular biochemistry, 2012, Volume: 59 Topics: Alzheimer Disease; Animals; Biological Transport; Calcium; Down Syndrome; Exocytosis; Glutamic Acid; Humans; Neurons; Phosphatidylinositols; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; SNARE Proteins; Synapses; Synaptic Transmission	2012
Alzheimer's disease, β-amyloid, glutamate, NMDA receptors and memantine--searching for the connections. British journal of pharmacology, 2012, Volume: 167, Issue:2 Topics: Alzheimer Disease; Amyloid beta-Peptides; Dopamine Agents; Glutamic Acid; Humans; Memantine; Receptors, N-Methyl-D-Aspartate	2012
The role of glutamatergic inputs onto parvalbumin-positive interneurons: relevance for schizophrenia. Reviews in the neurosciences, 2012, Jan-09, Volume: 23, Issue:1 Topics: Alzheimer Disease; Animals; Brain; Glutamic Acid; Humans; Interneurons; Neural Pathways; Parvalbumins	2012
Glutamate system, amyloid ß peptides and tau protein: functional interrelationships and relevance to Alzheimer disease pathology. Journal of psychiatry & neuroscience : JPN, 2013, Volume: 38, Issue:1 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Memantine; Neurofibrillary Tangles; Phosphorylation; Synaptic Membranes; tau Proteins	2013
Learning may provide neuroprotection against dementia. The West Indian medical journal, 2002, Volume: 51, Issue:3 Topics: Alzheimer Disease; Animals; Dementia; Educational Status; Glutamic Acid; Humans; Learning; Long-Term Potentiation; Memory; Risk Factors	2002
[Memantine]. Neurologia (Barcelona, Spain), 2003, Volume: 18, Issue:5 Topics: Aged; Alzheimer Disease; Antiparkinson Agents; Brain; Glutamic Acid; Humans; Memantine	2003
The glutamatergic system and Alzheimer's disease: therapeutic implications. CNS drugs, 2003, Volume: 17, Issue:9 Topics: Alzheimer Disease; Cell Death; Excitatory Amino Acid Agents; Glutamic Acid; Humans; Learning; Memantine; Memory; Receptors, N-Methyl-D-Aspartate	2003
The role of the N-methyl-D-aspartate receptor in Alzheimer's disease: therapeutic potential. Current neurology and neuroscience reports, 2003, Volume: 3, Issue:5 Topics: Alzheimer Disease; Animals; Brain; Clinical Trials as Topic; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Receptors, N-Methyl-D-Aspartate; Treatment Outcome	2003
Glutamatergic systems in Alzheimer's disease. International journal of geriatric psychiatry, 2003, Volume: 18, Issue:Suppl 1 Topics: Aged; Alzheimer Disease; Cell Death; Cognition; Glutamic Acid; Humans; Pyramidal Cells; Synaptic Transmission	2003
Glutamate and the glutamate receptor system: a target for drug action. International journal of geriatric psychiatry, 2003, Volume: 18, Issue:Suppl 1 Topics: Alzheimer Disease; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; N-Methylaspartate; Neuroprotective Agents; Receptors, Glutamate; Synaptic Transmission	2003
Pharmacological studies supporting the therapeutic use of Ginkgo biloba extract for Alzheimer's disease. Pharmacopsychiatry, 2003, Volume: 36 Suppl 1 Topics: Alzheimer Disease; Animals; Apoptosis; Brain Ischemia; Cells, Cultured; Cyclopentanes; Diterpenes; Dose-Response Relationship, Drug; Drug Interactions; Flavones; Flavonoids; Furans; Ginkgo biloba; Ginkgolides; Glutamic Acid; Humans; Hypoxia; Lactones; Neurons; Neuroprotective Agents; Plant Extracts; Time Factors	2003
Implications of the neuroprotective effects of lithium for the treatment of bipolar and neurodegenerative disorders. Pharmacopsychiatry, 2003, Volume: 36 Suppl 3 Topics: Alzheimer Disease; Bipolar Disorder; Glucocorticoids; Glutamic Acid; Humans; Huntington Disease; Lithium Compounds; Nerve Degeneration; Neurodegenerative Diseases; Neuroprotective Agents; Signal Transduction	2003
NMDA-antagonism (memantine): an alternative pharmacological therapeutic principle in Alzheimer's and vascular dementia. Current pharmaceutical design, 2004, Volume: 10, Issue:3 Topics: Alzheimer Disease; Clinical Trials as Topic; Dementia, Vascular; Dose-Response Relationship, Drug; Drug Interactions; Glutamic Acid; Humans; Memantine; Receptors, N-Methyl-D-Aspartate	2004
[Memantine (Ebixa), glutaminergic modulator]. Revue medicale de Bruxelles, 2004, Volume: 25, Issue:2 Topics: Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Excitatory Amino Acid Antagonists; Glutamic Acid; Glutamine; Humans; Indans; Memantine; Piperidines	2004
NMDA receptor antagonists. A new therapeutic approach for Alzheimer's disease. Geriatrics, 2004, Volume: 59, Issue:6 Topics: Alzheimer Disease; Cholinesterase Inhibitors; Disease Progression; Donepezil; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Indans; Memantine; Piperidines; Receptors, N-Methyl-D-Aspartate	2004
Glutamate-mediated excitotoxicity and neurodegeneration in Alzheimer's disease. Neurochemistry international, 2004, Volume: 45, Issue:5 Topics: Alzheimer Disease; Animals; Biogenic Polyamines; Excitatory Amino Acids; Glutamic Acid; Humans; Nerve Degeneration; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission	2004
1H-MRS evaluation of metabolism in Alzheimer's disease and vascular dementia. Neurological research, 2004, Volume: 26, Issue:5 Topics: Acetylcholine; Alzheimer Disease; Aspartic Acid; Cerebral Cortex; Dementia, Vascular; Glutamic Acid; Humans; Inositol; Magnetic Resonance Spectroscopy; Neurons	2004
Implications for atypical antipsychotics in the treatment of schizophrenia: neurocognition effects and a neuroprotective hypothesis. Pharmacotherapy, 2004, Volume: 24, Issue:12 Topics: Alzheimer Disease; Animals; Antipsychotic Agents; Apoptosis; Catechol O-Methyltransferase; Cognition; Cognition Disorders; Drug Therapy, Combination; Glutamic Acid; Hippocampus; Humans; Neuroprotective Agents; Prefrontal Cortex; Psychotic Disorders; Schizophrenia	2004
Indicators of neuroprotection with galantamine. Brain research bulletin, 2005, Jan-30, Volume: 64, Issue:6 Topics: Acetylcholine; Alzheimer Disease; Amyloid beta-Peptides; Animals; Disease Models, Animal; Galantamine; Glutamic Acid; Humans; In Vitro Techniques; Indicators and Reagents; Models, Biological; Neuroprotective Agents; Treatment Outcome	2005
[An update on the pharmacological treatment of Alzheimer disease]. Revista medica de Chile, 2005, Volume: 133, Issue:2 Topics: Acetylcholine; Alzheimer Disease; Cholinesterase Inhibitors; Glutamic Acid; Humans; Neurotransmitter Agents; Vasodilator Agents	2005
Glutamate transporters as drug targets. Current drug targets. CNS and neurological disorders, 2005, Volume: 4, Issue:2 Topics: Alzheimer Disease; Amino Acid Transport System X-AG; Amyotrophic Lateral Sclerosis; Animals; Biological Transport; Brain Ischemia; Drug Design; Epilepsy; Glutamic Acid; Humans; Membrane Transport Proteins; Schizophrenia; Transport Vesicles	2005
Association of the endothelial nitric oxide synthase (NOS3) Glu298Asp gene polymorphism with the risk of Alzheimer's disease-- a meta-analysis. Journal of neurology, 2005, Volume: 252, Issue:10 Topics: Alleles; Alzheimer Disease; Asian People; Aspartic Acid; Case-Control Studies; Confidence Intervals; Gene Frequency; Genotype; Glutamic Acid; Homozygote; Humans; Models, Statistical; Nitric Oxide Synthase Type III; Odds Ratio; Polymorphism, Genetic; Risk Factors; White People	2005
Neuropathology in Alzheimer's disease: target of pharmacotherapy. Journal of the American Academy of Nurse Practitioners, 2005, Volume: Suppl Topics: Acetylcholine; Alzheimer Disease; Amyloid beta-Peptides; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Cholinesterase Inhibitors; Disease Progression; Estrogens; Glutamic Acid; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; N-Methylaspartate; Neurofibrillary Tangles; Neuropharmacology; Neurotransmitter Agents	2005
Pharmacologic treatment options in Alzheimer's disease: optimizing disease management. Journal of the American Academy of Nurse Practitioners, 2005, Volume: Suppl Topics: Acetylcholine; Alzheimer Disease; Cholinesterase Inhibitors; Clinical Trials as Topic; Disease Management; Donepezil; Drug Therapy, Combination; Excitatory Amino Acid Antagonists; Galantamine; Glutamic Acid; Humans; Indans; Memantine; Nootropic Agents; Phenylcarbamates; Piperidines; Receptors, N-Methyl-D-Aspartate; Rivastigmine; Severity of Illness Index; Tacrine; Treatment Outcome	2005
Memantine: a therapeutic approach in treating Alzheimer's and vascular dementia. Current drug targets. CNS and neurological disorders, 2005, Volume: 4, Issue:5 Topics: Alzheimer Disease; Animals; Dementia, Vascular; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Memantine; Nootropic Agents; Receptors, N-Methyl-D-Aspartate	2005
Functional pharmacology in human brain. Pharmacological reviews, 2006, Volume: 58, Issue:2 Topics: Acetylcholine; Alzheimer Disease; Brain; Brain Ischemia; Epilepsy; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Neurons; Norepinephrine; Receptors, Adrenergic; Receptors, Cholinergic; Receptors, GABA; Receptors, Glutamate; Synaptic Transmission	2006
Pharmacology of acetylcholinesterase inhibitors and N-methyl-D-aspartate receptors for combination therapy in the treatment of Alzheimer's disease. Journal of clinical pharmacology, 2006, Volume: 46, Issue:7 Suppl 1 Topics: Acetylcholine; Alzheimer Disease; Animals; Brain; Cholinesterase Inhibitors; Drug Therapy, Combination; Excitatory Amino Acid Antagonists; Galantamine; Glutamic Acid; Humans; Memantine; Receptors, N-Methyl-D-Aspartate; Receptors, Nicotinic	2006
New targets for pharmacological intervention in the glutamatergic synapse. European journal of pharmacology, 2006, Sep-01, Volume: 545, Issue:1 Topics: Alzheimer Disease; Animals; Epilepsy; Glutamic Acid; Humans; Huntington Disease; Ischemia; Parkinson Disease; Protein Kinases; Receptors, N-Methyl-D-Aspartate; Synapses	2006
Potential role of N-methyl-D-aspartate receptors as executors of neurodegeneration resulting from diverse insults: focus on memantine. Behavioural pharmacology, 2006, Volume: 17, Issue:5-6 Topics: Alzheimer Disease; Animals; Brain; Cell Death; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Memantine; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Receptors, N-Methyl-D-Aspartate	2006
From benefit to damage. Glutamate and advanced glycation end products in Alzheimer brain. Journal of neural transmission (Vienna, Austria : 1996), 2006, Volume: 113, Issue:11 Topics: Acetylcholine; Alzheimer Disease; Animals; Brain; Glutamic Acid; Glycation End Products, Advanced; Humans; Synaptic Transmission	2006
Glutamate-glutamine cycling in Alzheimer's disease. Neurochemistry international, 2007, Volume: 50, Issue:7-8 Topics: Alzheimer Disease; Cell Membrane; Glutamic Acid; Glutamine; Humans; Models, Neurological; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate	2007
D-serine: a new word in the glutamatergic neuro-glial language. Amino acids, 2007, Volume: 33, Issue:4 Topics: Alzheimer Disease; Animals; Astrocytes; Cell Death; Cell Movement; Glutamic Acid; Humans; Neuroglia; Neurons; Neurotransmitter Agents; Schizophrenia; Serine; Synapses; Synaptic Transmission	2007
Glutamate release from astrocytes in physiological conditions and in neurodegenerative disorders characterized by neuroinflammation. International review of neurobiology, 2007, Volume: 82 Topics: AIDS Dementia Complex; Alzheimer Disease; Animals; Astrocytes; Calcium; Glutamic Acid; Humans; Inflammation; Neurodegenerative Diseases	2007
Amyloid beta peptides and glutamatergic synaptic dysregulation. Experimental neurology, 2008, Volume: 210, Issue:1 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Glutamic Acid; Humans; Models, Biological; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission	2008
Glutamatergic approaches to the treatment of cognitive and behavioural symptoms of Alzheimer's disease. Neuro-degenerative diseases, 2008, Volume: 5, Issue:3-4 Topics: Alzheimer Disease; Behavioral Symptoms; Cognition Disorders; Glutamic Acid; Humans; Memantine; Neuroprotective Agents; Serotonin Antagonists	2008
MAGUK proteins: new targets for pharmacological intervention in the glutamatergic synapse. European journal of pharmacology, 2008, May-06, Volume: 585, Issue:1 Topics: Alzheimer Disease; Animals; Antiparkinson Agents; Chronic Disease; Disks Large Homolog 4 Protein; Dyskinesia, Drug-Induced; Glutamic Acid; Guanylate Kinases; Humans; Huntington Disease; Intracellular Signaling Peptides and Proteins; Levodopa; Membrane Proteins; Pain; Protein Subunits; Receptors, N-Methyl-D-Aspartate; Stroke; Synapses	2008
Cholinergic and glutamatergic alterations beginning at the early stages of Alzheimer disease: participation of the phospholipase A2 enzyme. Psychopharmacology, 2008, Volume: 198, Issue:1 Topics: Aged; Alzheimer Disease; Glutamic Acid; Humans; Parasympathetic Nervous System; Phospholipases A2; Receptors, Cholinergic; Synaptic Transmission	2008
[Treatment of Alzheimer's disease: status quo and future considerations]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2008, Volume: 131, Issue:5 Topics: Acetylcholine; Alzheimer Disease; Amyloid beta-Peptides; Behavioral Symptoms; Choline; Cholinesterase Inhibitors; Cognition; Donepezil; Drug Design; Galantamine; Glutamic Acid; Humans; Indans; Phenylcarbamates; Piperidines; Receptors, N-Methyl-D-Aspartate; Risk Factors; Rivastigmine	2008
Maturation-dependent sensitivity of oligodendrocyte lineage cells to apoptosis: implications for normal development and disease. Cell death and differentiation, 2008, Volume: 15, Issue:7 Topics: Alzheimer Disease; Animals; Antioxidants; Apoptosis; Brain Diseases; Cell Differentiation; Cell Lineage; Cell Survival; Central Nervous System; Glutamic Acid; Humans; Multiple Sclerosis; Myelin Sheath; Oligodendroglia; Reactive Oxygen Species; Schizophrenia	2008
Neurotransmitter specific alterations in dementing disorders: insights from animal models. Journal of psychiatric research, 1984, Volume: 18, Issue:4 Topics: Alzheimer Disease; Animals; Brain; Cats; Cerebral Cortex; Cholinergic Fibers; Dementia; Disease Models, Animal; Dopamine; G(M1) Ganglioside; gamma-Aminobutyric Acid; Gangliosidoses; Glutamates; Glutamic Acid; Humans; Neurotransmitter Agents; Norepinephrine; Rats; Serotonin; Synaptic Transmission	1984
Noncompetitive NMDA receptor antagonists with fast open-channel blocking kinetics and strong voltage-dependency as potential therapeutic agents for Alzheimer's dementia. Pharmacopsychiatry, 1995, Volume: 28, Issue:4 Topics: Alzheimer Disease; Electrophysiology; Glutamic Acid; Humans; Ion Channels; Neuroprotective Agents; Receptors, N-Methyl-D-Aspartate	1995
Excitotoxic mechanisms in the pathogenesis of dementia. Neurochemistry international, 1994, Volume: 25, Issue:3 Topics: Alzheimer Disease; Biological Transport; Cell Death; Excitatory Amino Acids; Glutamic Acid; Humans; Neurons	1994
Modulation of AMPA receptor function in relation to glutamatergic abnormalities in Alzheimer's disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 1994, Volume: 48, Issue:7 Topics: Alzheimer Disease; Animals; Glutamic Acid; In Vitro Techniques; Neurons; Rats; Receptors, AMPA	1994
Glutamate, beta-amyloid precursor proteins, and calcium mediated neurofibrillary degeneration. Journal of neural transmission. Supplementum, 1994, Volume: 44 Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Calcium; Chromosomes, Human, Pair 14; Chromosomes, Human, Pair 19; Chromosomes, Human, Pair 21; Glutamic Acid; Humans; Models, Neurological; Mutation; Nerve Degeneration; Neurofibrillary Tangles; Rats	1994
Inhibition of brain tubulin-guanosine 5'-triphosphate interactions by mercury: similarity to observations in Alzheimer's diseased brain. Metal ions in biological systems, 1997, Volume: 34 Topics: Administration, Inhalation; Alzheimer Disease; Animals; Binding Sites; Brain; Chelating Agents; Edetic Acid; Egtazic Acid; Glutamic Acid; Guanosine Triphosphate; Humans; Isotope Labeling; Mercury; Microtubules; Nucleotides; Rats; Tubulin	1997
Pathogenesis of decreased glucose turnover and oxidative phosphorylation in ischemic and trauma-induced dementia of the Alzheimer type. Annals of the New York Academy of Sciences, 1997, Sep-26, Volume: 826 Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Brain Injuries; Brain Ischemia; Glucose; Glutamic Acid; Heat Stroke; Humans; Mitochondria; Oxidative Phosphorylation	1997
Glutamic acid and Alzheimer's disease. Neurobiology (Budapest, Hungary), 1998, Volume: 6, Issue:1 Topics: Alzheimer Disease; Glutamic Acid; Humans; Nerve Degeneration; Neurons; Synaptic Transmission	1998
Importance of immunological and inflammatory processes in the pathogenesis and therapy of Alzheimer's disease. The International journal of neuroscience, 1998, Volume: 95, Issue:3-4 Topics: Acute-Phase Proteins; Alzheimer Disease; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Autoantibodies; Autoimmunity; Brain; Calcium; Complement System Proteins; Cytokines; Endopeptidases; Glutamic Acid; Humans; Immunity, Cellular; Inflammation; Ion Transport; Microglia; Models, Biological; Nerve Tissue Proteins; Neurotoxins; Rats	1998
Adverse psychological impact, glutamatergic dysfunction, and risk factors for Alzheimer's disease. Neuroscience and biobehavioral reviews, 1998, Volume: 23, Issue:1 Topics: Alzheimer Disease; Animals; Glutamic Acid; Humans; Risk Factors	1998
The glutamate synapse in neuropsychiatric disorders. Focus on schizophrenia and Alzheimer's disease. Progress in brain research, 1998, Volume: 116 Topics: Alzheimer Disease; Animals; Glutamic Acid; Humans; Mental Disorders; Schizophrenia; Synapses	1998
Amyloid beta-peptide inhibits Na+-dependent glutamate uptake. Life sciences, 1999, Volume: 65, Issue:18-19 Topics: Alzheimer Disease; Amyloid beta-Peptides; Astrocytes; Glutamic Acid; Humans; Sodium	1999
Oxidative phosphorylation defects and Alzheimer's disease. Neurogenetics, 1997, Volume: 1, Issue:1 Topics: Alzheimer Disease; Amyloid beta-Peptides; DNA, Mitochondrial; Electron Transport Complex IV; Glutamic Acid; Humans; Models, Biological; Mutation; Oxidative Phosphorylation	1997
Real or imaginary? Human metabolism through nuclear magnetism. IUBMB life, 2000, Volume: 50, Issue:3 Topics: Alzheimer Disease; Animals; Brain; Down Syndrome; Glutamic Acid; History, 20th Century; Humans; In Vitro Techniques; Inositol; Liver; Magnetic Resonance Spectroscopy; Metabolism; Muscle, Skeletal; Phosphocreatine; Rats; Urea	2000
Does modulation of glutamatergic function represent a viable therapeutic strategy in Alzheimer's disease? Biological psychiatry, 1992, Feb-15, Volume: 31, Issue:4 Topics: Aged; Alzheimer Disease; Brain; Glutamates; Glutamic Acid; Humans; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter	1992
Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses? Annals of neurology, 1992, Volume: 31, Issue:2 Topics: Aging; Alzheimer Disease; Animals; Brain Diseases; Cell Death; Energy Metabolism; Glutamates; Glutamic Acid; Humans; Huntington Disease; Ion Channel Gating; Mitochondria; Models, Biological; MPTP Poisoning; Nerve Degeneration; Neurons; Neurotoxins; Oxidative Phosphorylation; Parkinson Disease; Parkinson Disease, Secondary; Primates; Rats; Receptors, N-Methyl-D-Aspartate	1992
Tacrine in relation to amino acid transmitters in Alzheimer's disease. Advances in neurology, 1990, Volume: 51 Topics: Alzheimer Disease; Aminoacridines; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Humans; Tacrine	1990
Treatment of Alzheimer's disease. Molecular pathology versus neurotransmitter-based therapy. The British journal of psychiatry : the journal of mental science, 1990, Volume: 157 Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Cerebral Cortex; Chromosomes, Human, Pair 21; Cloning, Molecular; Cycloserine; Glutamates; Glutamic Acid; Humans; Neurotransmitter Agents; Protease Inhibitors; Protein Precursors; Receptors, N-Methyl-D-Aspartate	1990
Clinical correlations of the neurobiological changes of aging. Annales de medecine interne, 1990, Volume: 141 Suppl 1 Topics: Aged; Aging; Alzheimer Disease; Amino Acids; Cerebral Cortex; Depressive Disorder; Energy Metabolism; Glutamates; Glutamic Acid; Humans; Neurons	1990
Excitotoxin-mediated neuron death in youth and old age. Progress in brain research, 1990, Volume: 86 Topics: Aging; Alzheimer Disease; Amino Acids; Animals; Aspartic Acid; Brain Diseases, Metabolic; Brain Injuries; Calcium Channels; Cell Survival; Central Nervous System; Central Nervous System Diseases; Food; Food Additives; Glutamates; Glutamic Acid; Humans; Ion Channel Gating; Neurons; Neurotoxins; Rats; Receptors, N-Methyl-D-Aspartate	1990
[Working hypothesis for the pharmacologic research in the glutamatergic approach to Alzheimer's disease]. Annales pharmaceutiques francaises, 1989, Volume: 47, Issue:6 Topics: Alzheimer Disease; Animals; Glutamates; Glutamic Acid; Glycine; Lactones	1989
Possible therapeutic applications of antagonists of excitatory amino acid neurotransmitters. Clinical science (London, England : 1979), 1985, Volume: 68, Issue:2 Topics: Alzheimer Disease; Animals; Aspartic Acid; Basal Ganglia Diseases; Brain; Brain Ischemia; Epilepsy; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Humans; Huntington Disease; Mice; Movement Disorders; Nerve Degeneration; Neurotransmitter Agents; Parkinson Disease; Rats	1985
The ageing brain and dementia--a review. British journal of clinical practice. Supplement, 1985, Volume: 39 Topics: Alzheimer Disease; Cerebral Cortex; Choline O-Acetyltransferase; Cholinergic Fibers; Dementia; Glutamates; Glutamic Acid; Humans; Neurotransmitter Agents	1985
Pathogenesis of Alzheimer's disease--beyond the cholinergic hypothesis: discussion paper. Journal of the Royal Society of Medicine, 1986, Volume: 79, Issue:6 Topics: Alzheimer Disease; Cerebral Cortex; Choline; Glutamates; Glutamic Acid; Humans; Somatostatin	1986
Are the neurochemical and behavioral changes induced by lesions of the nucleus basalis in the rat a model of Alzheimer's disease? Progress in neuro-psychopharmacology & biological psychiatry, 1986, Volume: 10, Issue:3-5 Topics: Alzheimer Disease; Animals; Basal Ganglia; Behavior, Animal; Choline; Choline O-Acetyltransferase; Disease Models, Animal; Glutamates; Glutamic Acid; Rats; Receptors, Muscarinic; Substantia Innominata	1986
Glutamate transmission and toxicity in Alzheimer's disease. Progress in neuro-psychopharmacology & biological psychiatry, 1988, Volume: 12, Issue:4 Topics: Alzheimer Disease; Cerebral Cortex; Glutamates; Glutamic Acid; Hippocampus; Humans; Receptors, Glutamate; Receptors, Neurotransmitter; Synaptic Transmission	1988

Trials

5 trial(s) available for glutamic acid and Acute Confusional Senile Dementia

Article	Year
Empagliflozin Induced Ketosis, Upregulated IGF-1/Insulin Receptors and the Canonical Insulin Signaling Pathway in Neurons, and Decreased the Excitatory Neurotransmitter Glutamate in the Brain of Non-Diabetics. Cells, 2022, 10-25, Volume: 11, Issue:21 Topics: Alzheimer Disease; Blood Glucose; Brain; Diabetes Mellitus, Type 2; Female; Glutamic Acid; Humans; Insulin; Insulin-Like Growth Factor I; Insulin, Regular, Human; Ketosis; Middle Aged; Neurons; Neurotransmitter Agents; Placenta Growth Factor; Receptor, Insulin; Signal Transduction; Sodium-Glucose Transporter 2 Inhibitors	2022
Increased glutamate in the hippocampus after galantamine treatment for Alzheimer disease. Progress in neuro-psychopharmacology & biological psychiatry, 2010, Feb-01, Volume: 34, Issue:1 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain Mapping; Choline; Cholinesterase Inhibitors; Creatine; Female; Galantamine; Glutamic Acid; Hippocampus; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Mental Status Schedule; Neuropsychological Tests; Regression Analysis	2010
Reduced glutamate neurotransmission in patients with Alzheimer's disease -- an in vivo (13)C magnetic resonance spectroscopy study. Magma (New York, N.Y.), 2003, Volume: 16, Issue:1 Topics: Adult; Aged; Alzheimer Disease; Brain; Brain Chemistry; Carbon Isotopes; Glucose; Glutamic Acid; Humans; Magnetic Resonance Spectroscopy; Middle Aged; Neurotransmitter Agents; Pilot Projects; Protons; Synaptic Transmission	2003
Fibroblast glutamate transport in aging and in AD: correlations with disease severity. Neurobiology of aging, 2005, Volume: 26, Issue:6 Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amino Acid Transport System X-AG; Biological Transport; Cells, Cultured; Excitatory Amino Acid Transporter 1; Female; Fibroblasts; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Humans; Male; Middle Aged; Severity of Illness Index; Statistics as Topic; Symporters	2005
AMPA potentiator treatment of cognitive deficits in Alzheimer disease. Neurology, 2007, Mar-27, Volume: 68, Issue:13 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Biphenyl Compounds; Brain; Cognition Disorders; Double-Blind Method; Excitatory Amino Acid Agonists; Female; Glutamic Acid; Humans; Male; Middle Aged; Neuropsychological Tests; Placebos; Receptors, AMPA; Sulfonamides; Synaptic Transmission; Treatment Outcome	2007

Other Studies

392 other study(ies) available for glutamic acid and Acute Confusional Senile Dementia

Article	Year
Long-term depression links amyloid-β to the pathological hyperphosphorylation of tau. Cell reports, 2021, 08-31, Volume: 36, Issue:9 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Excitatory Postsynaptic Potentials; Female; Glutamic Acid; Hippocampus; In Vitro Techniques; Long-Term Synaptic Depression; Male; Mice, Inbred C57BL; Peptide Fragments; Phosphorylation; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synapses; tau Proteins	2021
The role of glutamate in a multifactorial scenario of Alzheimer' disease associated with depression and poor sleep. Psychiatry research, 2021, Volume: 305 Topics: Alzheimer Disease; Depression; Glutamic Acid; Humans; Sleep; Sleep Initiation and Maintenance Disorders	2021
Human neocortical expansion involves glutamatergic neuron diversification. Nature, 2021, Volume: 598, Issue:7879 Topics: Alzheimer Disease; Animals; Cell Shape; Collagen; Electrophysiology; Extracellular Matrix Proteins; Female; Glutamic Acid; Humans; Lysine; Male; Mice; Neocortex; Neurons; Patch-Clamp Techniques; Transcriptome	2021
Neurotransmitter-stimulated neuron-derived sEVs have opposite effects on amyloid β-induced neuronal damage. Journal of nanobiotechnology, 2021, Oct-15, Volume: 19, Issue:1 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Disease Models, Animal; Extracellular Vesicles; gamma-Aminobutyric Acid; Glutamic Acid; Male; Mice; Mice, Transgenic; Neurons; Neurotransmitter Agents	2021
Differential Effects of Human P301L Tau Expression in Young versus Aged Mice. International journal of molecular sciences, 2021, Oct-28, Volume: 22, Issue:21 Topics: Aging; Alzheimer Disease; Animals; Gene Expression; Glutamic Acid; Humans; Male; Maze Learning; Mice; Mice, Transgenic; Mutation; tau Proteins	2021
Nitric oxide impairs spatial learning and memory in a rat model of Alzheimer's disease via disturbance of glutamate response in the hippocampal dentate gyrus during spatial learning. Behavioural brain research, 2022, 03-26, Volume: 422 Topics: Alzheimer Disease; Animals; Behavior, Animal; Dentate Gyrus; Disease Models, Animal; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Female; Glutamic Acid; Maze Learning; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Ovariectomy; Rats; Rats, Sprague-Dawley	2022
Dendritic distribution of CDK5 mRNA and p35 mRNA, and a glutamate-responsive increase of CDK5/p25 complex contribute to tau hyperphosphorylation. Biochimica et biophysica acta. General subjects, 2022, Volume: 1866, Issue:7 Topics: Alzheimer Disease; Animals; Cells, Cultured; Cyclin-Dependent Kinase 5; Glutamic Acid; Glycogen Synthase Kinase 3 beta; Humans; Mice; Phosphorylation; Phosphotransferases; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; tau Proteins	2022
Alterations in the transcriptional profile of genes related to glutamatergic signalling in animal models of Alzheimer's disease. The effect of fingolimod. Folia neuropathologica, 2022, Volume: 60, Issue:1 Topics: Alzheimer Disease; Animals; Fingolimod Hydrochloride; Glutamic Acid; Mice; Models, Animal; Signal Transduction	2022
Amyloid pathology disrupts gliotransmitter release in astrocytes. PLoS computational biology, 2022, Volume: 18, Issue:8 Topics: Alzheimer Disease; Amyloid beta-Peptides; Astrocytes; Calcium; Calcium Signaling; Glutamic Acid; Humans; Synaptic Transmission	2022
NeuroImage. Clinical, 2022, Volume: 36 Topics: Aged; Alzheimer Disease; Aspartic Acid; Cognition; Cognitive Dysfunction; Creatine; Glutamic Acid; Humans; Inositol; Proton Magnetic Resonance Spectroscopy	2022
Increased K Cells, 2022, 09-09, Volume: 11, Issue:18 Topics: Alzheimer Disease; Animals; Cells, Cultured; Cluster Analysis; Glutamic Acid; Hippocampus; Mice; Neurons; Potassium; Shab Potassium Channels	2022
Spatio-temporal metabolic rewiring in the brain of TgF344-AD rat model of Alzheimer's disease. Scientific reports, 2022, 10-10, Volume: 12, Issue:1 Topics: Alzheimer Disease; Animals; Brain; Choline; Creatine; Disease Models, Animal; Disease Progression; Glutamic Acid; Inositol; Rats; Taurine	2022
Effects of Donepezil Treatment on Brain Metabolites, Gut Microbiota, and Gut Metabolites in an Amyloid Beta-Induced Cognitive Impairment Mouse Pilot Model. Molecules (Basel, Switzerland), 2022, Oct-05, Volume: 27, Issue:19 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Cognitive Dysfunction; Disease Models, Animal; Donepezil; Gastrointestinal Microbiome; Glutamic Acid; Glycerol; Hypoxanthines; Inosine; Mice; Oxalates; Phenylalanine; Pyrrolidonecarboxylic Acid; Xylose	2022
Acute manganese exposure impairs glutamatergic function in a young mouse model of Alzheimer's disease. Neurotoxicology, 2023, Volume: 95 Topics: Alzheimer Disease; Animals; Brain; Glutamic Acid; Manganese; Manganese Poisoning; Mice	2023
Asymmetric dysregulation of glutamate dynamics across the synaptic cleft in a mouse model of Alzheimer's disease. Acta neuropathologica communications, 2023, 02-14, Volume: 11, Issue:1 Topics: Alzheimer Disease; Animals; Glutamic Acid; Hippocampus; Mice; Neurons; Synapses	2023
Nanoelectrochemistry reveals how soluble Aβ Proceedings of the National Academy of Sciences of the United States of America, 2023, 05-09, Volume: 120, Issue:19 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Glutamic Acid; Mice; Neurons; Peptide Fragments	2023
Transcriptomic analysis of glutamate-induced HT22 neurotoxicity as a model for screening anti-Alzheimer's drugs. Scientific reports, 2023, 05-04, Volume: 13, Issue:1 Topics: Alzheimer Disease; Animals; Cell Line; Glutamic Acid; Hippocampus; Mice; Neurons; Oxidative Stress; Transcriptome	2023
Moschus ameliorates glutamate-induced cellular damage by regulating autophagy and apoptosis pathway. Scientific reports, 2023, 10-30, Volume: 13, Issue:1 Topics: Aged; Alzheimer Disease; Animals; Apoptosis; Autophagosomes; Autophagy; Cell Survival; Female; Glutamic Acid; Humans; PC12 Cells; Rats; Reactive Oxygen Species	2023
A vicious cycle of β amyloid-dependent neuronal hyperactivation. Science (New York, N.Y.), 2019, 08-09, Volume: 365, Issue:6453 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; CA1 Region, Hippocampal; Disease Models, Animal; Glutamic Acid; Humans; Long-Term Potentiation; Mice; Neurons; Plaque, Amyloid; Protein Multimerization	2019
Studies on the Neuroprotection of Osthole on Glutamate-Induced Apoptotic Cells and an Alzheimer's Disease Mouse Model via Modulation Oxidative Stress. Applied biochemistry and biotechnology, 2020, Volume: 190, Issue:2 Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Apoptosis; Coumarins; Disease Models, Animal; Glutamic Acid; Mice; Mice, Transgenic; Neuroprotection; NF-E2-Related Factor 2; Oxidative Stress; Presenilin-1; Signal Transduction	2020
D-glutamate, D-serine, and D-alanine differ in their roles in cognitive decline in patients with Alzheimer's disease or mild cognitive impairment. Pharmacology, biochemistry, and behavior, 2019, Volume: 185 Topics: Aged; Aged, 80 and over; Alanine; Alzheimer Disease; Behavioral Symptoms; Chromatography, Liquid; Cognition; Cognitive Dysfunction; Cohort Studies; Cross-Sectional Studies; Diet; Female; Glutamic Acid; Hospitals, University; Humans; Male; Middle Aged; Neuropsychological Tests; Serine; Taiwan	2019
Facilitation of glutamate, but not GABA, release in Familial Alzheimer's APP mutant Knock-in rats with increased β-cleavage of APP. Aging cell, 2019, Volume: 18, Issue:6 Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Female; gamma-Aminobutyric Acid; Glutamic Acid; Male; Mutation; Rats	2019
Aβ Analytical chemistry, 2019, 12-03, Volume: 91, Issue:23 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Biosensing Techniques; Electrochemistry; Glutamic Acid; Hippocampus; Humans; Neurons; Peptide Fragments; Time Factors; Vesicular Glutamate Transport Protein 1	2019
Age-Related Intraneuronal Aggregation of Amyloid-β in Endosomes, Mitochondria, Autophagosomes, and Lysosomes. Journal of Alzheimer's disease : JAD, 2020, Volume: 73, Issue:1 Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Autophagosomes; Cells, Cultured; Endosomes; Glutamic Acid; Humans; Immunohistochemistry; Lysosomes; Mice; Mice, Transgenic; Mitochondria; Neurons; Particle Size	2020
Pharmacological Characterizations of anti-Dementia Memantine Nitrate via Neuroprotection and Vasodilation ACS chemical neuroscience, 2020, 02-05, Volume: 11, Issue:3 Topics: Alzheimer Disease; Animals; Brain; Dementia, Vascular; Glutamic Acid; Memantine; Neurons; Neuroprotection; Neuroprotective Agents; Nitrates; Phosphatidylinositol 3-Kinases; Rats; Spatial Memory; Vasodilation	2020
Exploring the Multi-Target Performance of Mitochondriotropic Antioxidants against the Pivotal Alzheimer's Disease Pathophysiological Hallmarks. Molecules (Basel, Switzerland), 2020, Jan-09, Volume: 25, Issue:2 Topics: Acetylcholine; Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Cell Line; Cholinesterase Inhibitors; Coumaric Acids; Glutamic Acid; Humans; Iron; Mitochondria; Neurons; Neuroprotective Agents; Oxidative Stress; Protein Aggregation, Pathological	2020
Astrocyte senescence promotes glutamate toxicity in cortical neurons. PloS one, 2020, Volume: 15, Issue:1 Topics: Alzheimer Disease; Amino Acid Transport System X-AG; Astrocytes; Brain; Cell Cycle Checkpoints; Cellular Senescence; Gene Expression Regulation; Glutamic Acid; Humans; Nerve Degeneration; Neurons; Primary Cell Culture; X-Rays	2020
Reduced Hippocampal Glutamate and Posterior Cingulate N-Acetyl Aspartate in Mild Cognitive Impairment and Alzheimer's Disease Is Associated with Episodic Memory Performance and White Matter Integrity in the Cingulum: A Pilot Study. Journal of Alzheimer's disease : JAD, 2020, Volume: 73, Issue:4 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Cognitive Dysfunction; Diffusion Tensor Imaging; Female; Glutamic Acid; Gyrus Cinguli; Hippocampus; Humans; Limbic System; Magnetic Resonance Spectroscopy; Male; Memory, Episodic; Mental Status and Dementia Tests; Middle Aged; Neuropsychological Tests; Pilot Projects; White Matter	2020
Amyloid Fibril-Induced Astrocytic Glutamate Transporter Disruption Contributes to Complement C1q-Mediated Microglial Pruning of Glutamatergic Synapses. Molecular neurobiology, 2020, Volume: 57, Issue:5 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Aspartic Acid; Astrocytes; CA1 Region, Hippocampal; Ceftriaxone; Cognition Disorders; Complement C1q; Disease Models, Animal; Excitatory Amino Acid Transporter 2; Glutamic Acid; Male; Microglia; Morris Water Maze Test; Neurons; Patch-Clamp Techniques; Peptide Fragments; Phagocytosis; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Synapses; Up-Regulation	2020
A Dietary Ketone Ester Normalizes Abnormal Behavior in a Mouse Model of Alzheimer's Disease. International journal of molecular sciences, 2020, Feb-04, Volume: 21, Issue:3 Topics: Alzheimer Disease; Animals; Aspartic Acid; Brain; Citric Acid Cycle; Diet; Disease Models, Animal; Esters; Glucose; Glutamic Acid; Hippocampus; Ketone Bodies; Ketones; Ketosis; Male; Mice	2020
Iron dyshomeostasis, lipid peroxidation and perturbed expression of cystine/glutamate antiporter in Alzheimer's disease: Evidence of ferroptosis. Redox biology, 2020, Volume: 32 Topics: Alzheimer Disease; Antiporters; Cystine; Ferroptosis; Glutamic Acid; Humans; Iron; Lipid Peroxidation; Male	2020
Safflower Yellow Improves the Synaptic Structural Plasticity by Ameliorating the Disorder of Glutamate Circulation in Aβ Neurochemical research, 2020, Volume: 45, Issue:8 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cerebral Cortex; Chalcone; Dendritic Spines; Female; Glutamic Acid; Hippocampus; Learning; Male; Memory; Neuronal Plasticity; Neuroprotective Agents; Nootropic Agents; Peptide Fragments; Quinones; Rats, Sprague-Dawley; Synapses	2020
Positive allosteric activation of glial EAAT-2 transporter protein: A novel strategy for Alzheimer's disease. Medical hypotheses, 2020, Volume: 142 Topics: Allosteric Regulation; Alzheimer Disease; Excitatory Amino Acid Transporter 2; Glutamic Acid; Humans; Neuroglia	2020
Drinking water temperature affects cognitive function and progression of Alzheimer's disease in a mouse model. Acta pharmacologica Sinica, 2021, Volume: 42, Issue:1 Topics: Alzheimer Disease; Animals; Brain; Cognition; Cold Temperature; Disease Progression; Drinking Water; gamma-Aminobutyric Acid; Glutamic Acid; Insulin; Male; Mice, Inbred C57BL; Mice, Transgenic; Morris Water Maze Test; Neurotransmitter Agents; Open Field Test; Signal Transduction	2021
CD49f Is a Novel Marker of Functional and Reactive Human iPSC-Derived Astrocytes. Neuron, 2020, 08-05, Volume: 107, Issue:3 Topics: Alzheimer Disease; Animals; Astrocytes; Biomarkers; Flow Cytometry; Gene Expression Profiling; Glutamic Acid; Humans; Induced Pluripotent Stem Cells; Inflammation; Integrin alpha6; Mice; Patch-Clamp Techniques; Phagocytosis; RNA-Seq; Single-Cell Analysis	2020
NCX1 and EAAC1 transporters are involved in the protective action of glutamate in an in vitro Alzheimer's disease-like model. Cell calcium, 2020, Volume: 91 Topics: Adenosine Triphosphate; Alzheimer Disease; Animals; Cell Death; Cell Differentiation; Cell Line, Tumor; Cerebral Cortex; Excitatory Amino Acid Transporter 3; Glutamic Acid; Glyceraldehyde; Humans; Models, Biological; Neurons; Oxidative Stress; Protective Agents; Rats; Reactive Oxygen Species; Sodium-Calcium Exchanger; Tretinoin	2020
Hippocampal alterations in glutamatergic signaling during amyloid progression in AβPP/PS1 mice. Scientific reports, 2020, 09-02, Volume: 10, Issue:1 Topics: Alzheimer Disease; Amyloid; Amyloid beta-Protein Precursor; Animals; Cognition; Glutamic Acid; Glutamine; Hippocampus; Male; Maze Learning; Memory; Mice; Mice, Inbred C57BL; Microelectrodes; Signal Transduction	2020
Peripheral and Central Glutamate Dyshomeostasis in Neurodegenerative Disorders. Current neuropharmacology, 2021, Volume: 19, Issue:7 Topics: Alzheimer Disease; Animals; Brain; Glutamic Acid; Humans; Neurodegenerative Diseases; Synaptic Transmission	2021
Synthetic analogues of memantine as neuroprotective and influenza viral inhibitors: in vitro and physicochemical studies. Amino acids, 2020, Volume: 52, Issue:11-12 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Dogs; Glutamic Acid; Humans; Influenza, Human; Madin Darby Canine Kidney Cells; Memantine; Neuroprotective Agents; Orthomyxoviridae; Oxidative Stress	2020
Alterations of GABA B receptors in the APP/PS1 mouse model of Alzheimer's disease. Neurobiology of aging, 2021, Volume: 97 Topics: Alzheimer Disease; Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamic Acid; Memory; Mice, Transgenic; Neuroglia; Receptors, GABA-B; Signal Transduction; Spatial Learning	2021
Deficient astrocyte metabolism impairs glutamine synthesis and neurotransmitter homeostasis in a mouse model of Alzheimer's disease. Neurobiology of disease, 2021, Volume: 148 Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Astrocytes; Carbon Isotopes; Disease Models, Animal; gamma-Aminobutyric Acid; Gas Chromatography-Mass Spectrometry; Glutamic Acid; Glutamine; Hippocampus; Homeostasis; Mice; Mice, Transgenic; Neurotransmitter Agents; Presenilin-1	2021
Hippocampal hyperglutamatergic signaling matters: Early targeting glutamate neurotransmission as a preventive strategy in Alzheimer's disease: An Editorial Highlight for "Riluzole attenuates glutamatergic tone and cognitive decline in AβPP/PS1 mice" on pa Journal of neurochemistry, 2021, Volume: 156, Issue:4 Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Cognitive Dysfunction; Glutamic Acid; Hippocampus; Humans; Mice; Mice, Inbred C57BL; Mice, Transgenic; Riluzole; Synaptic Transmission	2021
Longitudinal GluCEST MRI Changes and Cerebral Blood Flow in 5xFAD Mice. Contrast media & molecular imaging, 2020, Volume: 2020 Topics: Alzheimer Disease; Animals; Brain; Cerebrovascular Circulation; Disease Models, Animal; Glutamic Acid; Humans; Image Processing, Computer-Assisted; Longitudinal Studies; Magnetic Resonance Imaging; Mice; Mice, Transgenic	2020
Hippocampal Degeneration and Behavioral Impairment During Alzheimer-Like Pathogenesis Involves Glutamate Excitotoxicity. Journal of molecular neuroscience : MN, 2021, Volume: 71, Issue:6 Topics: Alzheimer Disease; Animals; Behavior, Animal; Dentate Gyrus; Disks Large Homolog 4 Protein; Excitatory Amino Acid Antagonists; Glial Fibrillary Acidic Protein; Glutamic Acid; Glutathione Peroxidase; Glutathione Transferase; Ki-67 Antigen; Male; Memantine; Proliferating Cell Nuclear Antigen; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate	2021
Memantine ameliorates cognitive impairment induced by exposure to chronic hypoxia environment at high altitude by inhibiting excitotoxicity. Life sciences, 2021, Apr-01, Volume: 270 Topics: Altitude; Altitude Sickness; Alzheimer Disease; Animals; Cell Death; Cognition; Cognitive Dysfunction; Disease Models, Animal; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Hypoxia; Male; Memantine; Memory; Neurons; Neuroprotective Agents; Neurotoxins; Oxidative Stress; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate	2021
Insulin Receptors and Intracellular Ca F1000Research, 2020, Volume: 9 Topics: Alzheimer Disease; Calcium; Feedback, Physiological; Glutamic Acid; Humans; Insulin Resistance; Receptor, Insulin; Receptors, N-Methyl-D-Aspartate	2020
Osthole-Loaded Nanoemulsion Enhances Brain Target in the Treatment of Alzheimer's Disease via Intranasal Administration. Oxidative medicine and cellular longevity, 2021, Volume: 2021 Topics: Administration, Intranasal; Alzheimer Disease; Animals; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Brain; Caspase 3; Cell Line, Tumor; Cell Survival; Choline; Coumarins; Cytoprotection; Drug Liberation; Emulsions; Glutamic Acid; Lipids; Memory; Mice; Nanoparticles; Oxidative Stress; Particle Size; Phase Transition; Scopolamine; Solubility; Static Electricity; Surface-Active Agents; Water	2021
Plasma d-glutamate levels for detecting mild cognitive impairment and Alzheimer's disease: Machine learning approaches. Journal of psychopharmacology (Oxford, England), 2021, Volume: 35, Issue:3 Topics: Aged; Aged, 80 and over; Algorithms; Alzheimer Disease; Biomarkers; Case-Control Studies; Chromatography, High Pressure Liquid; Cognitive Dysfunction; Diagnosis, Differential; Female; Glutamic Acid; Humans; Machine Learning; Male; Middle Aged; Psychiatric Status Rating Scales; Sensitivity and Specificity; Severity of Illness Index	2021
High performance liquid chromatography determination of L-glutamate, L-glutamine and glycine content in brain, cerebrospinal fluid and blood serum of patients affected by Alzheimer's disease. Amino acids, 2021, Volume: 53, Issue:3 Topics: Aged, 80 and over; Alzheimer Disease; Biomarkers; Chromatography, High Pressure Liquid; Female; Glutamic Acid; Glutamine; Glycine; Humans; Male; Prefrontal Cortex	2021
Downregulation of GABA Transporter 3 (GAT3) is Associated with Deficient Oxidative GABA Metabolism in Human Induced Pluripotent Stem Cell-Derived Astrocytes in Alzheimer's Disease. Neurochemical research, 2021, Volume: 46, Issue:10 Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Astrocytes; Down-Regulation; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Induced Pluripotent Stem Cells; Mutation; Presenilin-1	2021
Astrocytes respond to a neurotoxic Aβ fragment with state-dependent Ca Acta neuropathologica communications, 2021, 03-16, Volume: 9, Issue:1 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Newborn; Astrocytes; Calcium; Calcium Signaling; Cells, Cultured; Disease Models, Animal; Glutamic Acid; Mice; Neurotoxicity Syndromes; Peptide Fragments; Plasma Membrane Calcium-Transporting ATPases; Receptors, Purinergic P2Y	2021
Retinal Ganglion Cells Functional Changes in a Mouse Model of Alzheimer's Disease Are Linked with Neurotransmitter Alterations. Journal of Alzheimer's disease : JAD, 2021, Volume: 82, Issue:s1 Topics: Age Factors; Alzheimer Disease; Animals; Disease Models, Animal; Female; gamma-Aminobutyric Acid; Glutamic Acid; Male; Mice; Mice, Transgenic; Neurotransmitter Agents; Photic Stimulation; Retinal Ganglion Cells	2021
Small-World Networks and Their Relationship With Hippocampal Glutamine/Glutamate Concentration in Healthy Adults With Varying Genetic Risk for Alzheimer's Disease. Journal of magnetic resonance imaging : JMRI, 2021, Volume: 54, Issue:3 Topics: Adult; Alzheimer Disease; Brain; Glutamic Acid; Glutamine; Hippocampus; Humans; Magnetic Resonance Imaging; Prospective Studies	2021
Editorial for "Small-World Networks and Their Relationship With Hippocampal Glutamine/Glutamate (Glx) Concentration in Healthy Adults With Varying Genetic Risk for Alzheimer's Disease". Journal of magnetic resonance imaging : JMRI, 2021, Volume: 54, Issue:3 Topics: Adult; Alzheimer Disease; Glutamic Acid; Glutamine; Hippocampus; Humans; Magnetic Resonance Spectroscopy	2021
Amyloid-β (1-42) peptide induces rapid NMDA receptor-dependent alterations at glutamatergic synapses in the entorhinal cortex. Neurobiology of aging, 2021, Volume: 105 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Entorhinal Cortex; Glutamic Acid; Male; Peptide Fragments; Rats, Long-Evans; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission	2021
Ceftriaxone regulates glutamate production and vesicular assembly in presynaptic terminals through GLT-1 in APP/PS1 mice. Neurobiology of learning and memory, 2021, Volume: 183 Topics: Alzheimer Disease; Amino Acid Transport System A; Amyloid beta-Protein Precursor; Animals; Anti-Bacterial Agents; Ceftriaxone; Disease Models, Animal; Excitatory Amino Acid Transporter 2; Gene Knockdown Techniques; Glutamic Acid; Glutaminase; Mice; Mice, Transgenic; Presenilin-1; Presynaptic Terminals; Synaptic Vesicles; Vesicular Glutamate Transport Protein 1; Vesicular Glutamate Transport Protein 2	2021
Effects of Mild Excitotoxic Stimulus on Mitochondria Ca Cells, 2021, 08-10, Volume: 10, Issue:8 Topics: Alzheimer Disease; Animals; Calcium; Cells, Cultured; Cyclosporine; Disease Models, Animal; Electron Transport; Glutamic Acid; Hippocampus; Ions; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mitochondria; Neurotoxins; Reactive Oxygen Species	2021
Neuronal and Peripheral Pentraxins Modify Glutamate Release and may Interact in Blood-Brain Barrier Failure. Cerebral cortex (New York, N.Y. : 1991), 2017, 06-01, Volume: 27, Issue:6 Topics: Aged, 80 and over; Alzheimer Disease; Animals; Animals, Newborn; Blood-Brain Barrier; C-Reactive Protein; Evoked Potentials; Female; GABA Antagonists; Glutamic Acid; HEK293 Cells; Hippocampus; Humans; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Middle Aged; Nerve Tissue Proteins; Neurons; Pyridazines; Serum Amyloid P-Component; Synapses	2017
Targeting glutamate transporter-1 in neurological diseases. Oncotarget, 2017, Apr-04, Volume: 8, Issue:14 Topics: Alzheimer Disease; Amino Acid Transport System X-AG; Amyotrophic Lateral Sclerosis; Animals; Astrocytes; Disease Progression; Epilepsy; Excitatory Amino Acid Transporter 2; Gene Expression Regulation; Glutamate Plasma Membrane Transport Proteins; Glutamates; Glutamic Acid; Homeostasis; Humans; Mice; Models, Biological; Nervous System Diseases; Neurodegenerative Diseases	2017
Using Enzyme-based Biosensors to Measure Tonic and Phasic Glutamate in Alzheimer's Mouse Models. Journal of visualized experiments : JoVE, 2017, 05-03, Issue:123 Topics: Alzheimer Disease; Animals; Biosensing Techniques; Calibration; Electrodes; Enzymes, Immobilized; Glutamic Acid; Hippocampus; Humans; Mice; Mice, Transgenic; Microelectrodes; Phenylenediamines; Stereotaxic Techniques	2017
Precuneus Failures in Subjects of the PSEN1 E280A Family at Risk of Developing Alzheimer's Disease Detected Using Quantitative Electroencephalography. Journal of Alzheimer's disease : JAD, 2017, Volume: 58, Issue:4 Topics: Adult; Alanine; Alzheimer Disease; Brain Mapping; Brain Waves; Cognition Disorders; Electroencephalography; Female; Glutamic Acid; Humans; Male; Middle Aged; Neuropsychological Tests; Parietal Lobe; Polymorphism, Single Nucleotide; Presenilin-1; Principal Component Analysis; Psychiatric Status Rating Scales; Young Adult	2017
The Cdk5-Mcl-1 axis promotes mitochondrial dysfunction and neurodegeneration in a model of Alzheimer's disease. Journal of cell science, 2017, Sep-15, Volume: 130, Issue:18 Topics: Alzheimer Disease; Animals; Cell Nucleus; Cyclin-Dependent Kinase 5; Glutamic Acid; HEK293 Cells; Humans; Mice; Mitochondria; Models, Biological; Myeloid Cell Leukemia Sequence 1 Protein; Nerve Degeneration; Neurons; Neurotoxins; Phosphorylation; Phosphothreonine; Protein Transport; Proteolysis; Severity of Illness Index; Signal Transduction; Subcellular Fractions; Substrate Specificity; Ubiquitination	2017
Bladder cancer (Amsterdam, Netherlands), 2017, Jul-27, Volume: 3, Issue:3 Topics: Alleles; Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Newborn; Apoptosis; Calcium; Calcium Signaling; Caspase 12; Caspase 8; Caspase 9; Chromosome Mapping; Disease Resistance; Endoplasmic Reticulum Stress; Flow Cytometry; Genes, Dominant; Genes, Plant; Genotype; Glutamic Acid; Glycine max; Heart Injuries; Hippocampus; In Vitro Techniques; Mice; Mice, Inbred C57BL; Microsatellite Repeats; Myocardium; Myocytes, Cardiac; Neurons; Peptide Fragments; Plant Diseases; Potyvirus; Primary Cell Culture; Rats; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Sodium-Calcium Exchanger; Stem Cells	2017
NSCs promote hippocampal neurogenesis, metabolic changes and synaptogenesis in APP/PS1 transgenic mice. Hippocampus, 2017, Volume: 27, Issue:12 Topics: Alzheimer Disease; Animals; Aspartic Acid; Cognition Disorders; Creatine; Disease Models, Animal; Glutamic Acid; Hippocampus; Male; Mice, Inbred C57BL; Mice, Transgenic; Neural Stem Cells; Neurogenesis; Synapses	2017
Nature-based molecules combined with rivastigmine: A symbiotic approach for the synthesis of new agents against Alzheimer's disease. European journal of medicinal chemistry, 2017, Dec-01, Volume: 141 Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Biological Products; Butyrylcholinesterase; Cell Death; Cell Line, Tumor; Cell Survival; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Free Radical Scavengers; Glutamic Acid; Humans; Molecular Structure; Neuroprotective Agents; Peptide Fragments; Protein Aggregates; Rivastigmine; Structure-Activity Relationship	2017
Differential Pattern of Phospholipid Profile in the Temporal Cortex from E280A-Familiar and Sporadic Alzheimer's Disease Brains. Journal of Alzheimer's disease : JAD, 2018, Volume: 61, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Alanine; Alzheimer Disease; Analysis of Variance; Fatty Acids; Female; Gene Expression Regulation; Glutamic Acid; Humans; Lysophosphatidylcholines; Male; Mass Spectrometry; Middle Aged; Mutation; Phosphatidylethanolamines; Phospholipids; Presenilin-1; Temporal Lobe	2018
S100A9 Protein Aggregates Boost Hippocampal Glutamate Modifying Monoaminergic Neurochemistry: A Glutamate Antibody Sensitive Outcome on Alzheimer-like Memory Decline. ACS chemical neuroscience, 2018, 03-21, Volume: 9, Issue:3 Topics: Aging; Alzheimer Disease; Animals; Behavior, Animal; Calgranulin B; Glutamic Acid; Hippocampus; Memory Disorders; Mice; Neurotransmitter Agents; Protein Aggregates; Spatial Memory	2018
Neuronal pathophysiology featuring PrP Prion, 2018, 01-02, Volume: 12, Issue:1 Topics: Alzheimer Disease; Animals; Calcium; Cell Membrane; Cytosol; Glutamic Acid; Humans; Mice; Mice, Knockout; Mitochondria; Neurons; Neurotoxins; Primary Cell Culture; Prion Diseases; PrPC Proteins	2018
Neuroprotective, Neurogenic, and Amyloid Beta Reducing Effect of a Novel Alpha 2-Adrenoblocker, Mesedin, on Astroglia and Neuronal Progenitors upon Hypoxia and Glutamate Exposure. International journal of molecular sciences, 2017, Dec-21, Volume: 19, Issue:1 Topics: Adrenergic alpha-2 Receptor Antagonists; Alzheimer Disease; Amyloid beta-Peptides; Animals; Astrocytes; Biomarkers, Pharmacological; Cell Survival; Dioxanes; Glutamic Acid; Hypoxia; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurogenesis; Neurons; Neuroprotective Agents; Primary Cell Culture; Thiazoles	2017
Moderate decline in select synaptic markers in the prefrontal cortex (BA9) of patients with Alzheimer's disease at various cognitive stages. Scientific reports, 2018, 01-17, Volume: 8, Issue:1 Topics: Aged, 80 and over; Alzheimer Disease; Biomarkers; Choline O-Acetyltransferase; Cognition; Female; Glutamic Acid; Humans; Male; Neurons; Prefrontal Cortex; Synapses; Synaptophysin; Vesicular Glutamate Transport Protein 1; Vesicular Inhibitory Amino Acid Transport Proteins	2018
Amalaki Rasayana improved memory and neuronal metabolic activity in AbPP-PS1 mouse model of Alzheimer's disease. Journal of biosciences, 2017, Volume: 42, Issue:3 Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Brain; Carbon Isotopes; Cognition; Donepezil; gamma-Aminobutyric Acid; Gene Expression; Glucose; Glutamic Acid; Glutamine; Humans; Indans; Male; Maze Learning; Medicine, Ayurvedic; Memory; Mice; Mice, Transgenic; Neurons; Neuroprotective Agents; Piperidines; Plant Extracts; Presenilin-1	2017
Impact of amyloid-beta changes on cognitive outcomes in Alzheimer's disease: analysis of clinical trials using a quantitative systems pharmacology model. Alzheimer's research & therapy, 2018, 02-02, Volume: 10, Issue:1 Topics: Algorithms; alpha7 Nicotinic Acetylcholine Receptor; Alzheimer Disease; Amyloid beta-Peptides; Apolipoprotein E4; Clinical Trials as Topic; Cognition; Cognitive Dysfunction; Computer Simulation; Disease Progression; Glutamic Acid; Humans; Models, Neurological; Muscarinic Antagonists; Peptide Fragments; Scopolamine; Synaptic Transmission; Treatment Outcome	2018
Alteration of global protein SUMOylation in neurons and astrocytes in response to Alzheimer's disease-associated insults. Biochemical and biophysical research communications, 2018, 06-02, Volume: 500, Issue:2 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Astrocytes; Cells, Cultured; Glutamic Acid; Hydrogen Peroxide; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Transgenic; Neurons; Sumoylation	2018
Brain imaging and behavior, 2019, Volume: 13, Issue:4 Topics: Adult; Alzheimer Disease; Brain; Choline; Creatine; Cross-Sectional Studies; Female; Glutamic Acid; Gyrus Cinguli; Humans; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neuropeptides; Proton Magnetic Resonance Spectroscopy	2019
Possible prophylactic anti-excitotoxic and anti-oxidant effects of virgin coconut oil on aluminium chloride-induced Alzheimer's in rat models. Journal of integrative neuroscience, 2018, Volume: 17, Issue:3-4 Topics: Aluminum Chloride; Alzheimer Disease; Animals; Antioxidants; Cerebral Cortex; Coconut Oil; Disease Models, Animal; Glutamic Acid; Male; Memory, Short-Term; Motor Activity; Neuroprotective Agents; Random Allocation; Rats, Wistar; Recognition, Psychology	2018
Intracerebroventricular streptozotocin-induced Alzheimer's disease-like sleep disorders in rats: Role of the GABAergic system in the parabrachial complex. CNS neuroscience & therapeutics, 2018, Volume: 24, Issue:12 Topics: Alzheimer Disease; Analysis of Variance; Animals; Antibiotics, Antineoplastic; Arousal; Disease Models, Animal; Electroencephalography; Electromyography; gamma-Aminobutyric Acid; Glutamic Acid; Injections, Intraventricular; Male; Maze Learning; Parabrachial Nucleus; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Sleep Wake Disorders; Streptozocin	2018
Pharmacological basis for application of scutellarin in Alzheimer's disease: Antioxidation and antiapoptosis. Molecular medicine reports, 2018, Volume: 18, Issue:5 Topics: Alzheimer Disease; Animals; Antioxidants; Apigenin; Apoptosis; Apoptosis Regulatory Proteins; Biomarkers; Caspase 3; Cell Line; Disease Models, Animal; Glucuronates; Glutamic Acid; L-Lactate Dehydrogenase; Male; Matrix Metalloproteinases; Mice; Neuroprotective Agents; Oxidative Stress; Reactive Oxygen Species	2018
cPLA2 and desaturases underlie the tau hyperphosphorylation offset induced by BACE knock-down in neuronal primary cultures. Biochimica et biophysica acta. Molecular basis of disease, 2018, Volume: 1864, Issue:11 Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Apoptosis; Aspartic Acid Endopeptidases; Cerebral Cortex; Excitatory Postsynaptic Potentials; Gene Knockdown Techniques; Glutamic Acid; Group IV Phospholipases A2; Neurons; Phosphorylation; Primary Cell Culture; Rats; Rats, Wistar; RNA, Small Interfering; Stearoyl-CoA Desaturase; tau Proteins	2018
Ceftriaxone Improves Cognitive Function and Upregulates GLT-1-Related Glutamate-Glutamine Cycle in APP/PS1 Mice. Journal of Alzheimer's disease : JAD, 2018, Volume: 66, Issue:4 Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Anti-Bacterial Agents; Ceftriaxone; Cognition; Disease Models, Animal; Excitatory Amino Acid Transporter 2; Glutamic Acid; Glutamine; Hippocampus; Maze Learning; Mice; Mice, Transgenic; Presenilin-1; Up-Regulation	2018
Diet-induced insulin resistance elevates hippocampal glutamate as well as VGLUT1 and GFAP expression in AβPP/PS1 mice. Journal of neurochemistry, 2019, Volume: 148, Issue:2 Topics: Alzheimer Disease; Animals; Diet, High-Fat; Glial Fibrillary Acidic Protein; Glutamic Acid; Hippocampus; Insulin Resistance; Mice; Mice, Inbred C57BL; Mice, Transgenic; Vesicular Glutamate Transport Protein 1	2019
Nurr1 (NR4A2) regulates Alzheimer's disease-related pathogenesis and cognitive function in the 5XFAD mouse model. Aging cell, 2019, Volume: 18, Issue:1 Topics: Aging; Alzheimer Disease; Amodiaquine; Animals; Brain; Cognition; Disease Models, Animal; Glutamic Acid; Humans; Mice, Inbred C57BL; Mice, Transgenic; Neuroglia; Neurons; Nuclear Receptor Subfamily 4, Group A, Member 2; Postmortem Changes	2019
Investigation of the neuroprotective effects of crocin via antioxidant activities in HT22 cells and in mice with Alzheimer's disease. International journal of molecular medicine, 2019, Volume: 43, Issue:2 Topics: Alzheimer Disease; Animals; Antioxidants; Apoptosis; Calcium; Carotenoids; Cell Line; Cell Survival; Cognition; Disease Models, Animal; Glutamic Acid; Mice; Mitochondria; Neuroprotective Agents; Oxidative Stress; Pyramidal Cells; Reactive Oxygen Species	2019
Gene expression, proteome and calcium signaling alterations in immortalized hippocampal astrocytes from an Alzheimer's disease mouse model. Cell death & disease, 2019, 01-10, Volume: 10, Issue:1 Topics: Alzheimer Disease; Animals; Astrocytes; Calcium Signaling; Cells, Cultured; Disease Models, Animal; Excitatory Amino Acid Transporter 2; Gene Expression; Glutamic Acid; Hippocampus; Mice; Mice, Inbred C57BL; Mice, Transgenic; Protein Interaction Maps; Proteome; Synaptic Transmission; Transfection	2019
Novel Blood Biomarkers that Correlate with Cognitive Performance and Hippocampal Volumetry: Potential for Early Diagnosis of Alzheimer's Disease. Journal of Alzheimer's disease : JAD, 2019, Volume: 67, Issue:3 Topics: Aged; Alzheimer Disease; Amino Acids; Apolipoproteins E; Biomarkers; Blotting, Western; Case-Control Studies; Cognition; Cognitive Dysfunction; Early Diagnosis; Female; Glutamic Acid; Hippocampus; Humans; Magnetic Resonance Imaging; Male; Mental Status and Dementia Tests; Neuroimaging; Organ Size; Tandem Mass Spectrometry; Transaminases	2019
Combination of Memantine and 6-Chlorotacrine as Novel Multi-Target Compound against Alzheimer's Disease. Current Alzheimer research, 2019, Volume: 16, Issue:9 Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Blood-Brain Barrier; Capillary Permeability; Cell Survival; CHO Cells; Cholinesterase Inhibitors; Cricetulus; Glutamic Acid; HEK293 Cells; Humans; Ligands; Male; Memantine; Molecular Docking Simulation; Neuroprotective Agents; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Tacrine; Tissue Culture Techniques	2019
Simultaneous Live Imaging of Multiple Endogenous Proteins Reveals a Mechanism for Alzheimer's-Related Plasticity Impairment. Cell reports, 2019, 04-16, Volume: 27, Issue:3 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Disks Large Homolog 4 Protein; Female; Glutamic Acid; Hippocampus; Ionomycin; Long-Term Potentiation; Long-Term Synaptic Depression; Male; Membrane Proteins; N-Methylaspartate; Neuronal Plasticity; Protein Transport; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synapses	2019
Tuning of Glutamate, But Not GABA, Release by an Intrasynaptic Vesicle APP Domain Whose Function Can Be Modulated by β- or α-Secretase Cleavage. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019, 08-28, Volume: 39, Issue:35 Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Female; gamma-Aminobutyric Acid; Glutamic Acid; Male; Mice; Mice, Knockout; Rats; Rats, Long-Evans; Synaptic Transmission; Synaptic Vesicles	2019
Effect of antibodies to glutamate on caspase-3 activity in brain structures of rats with experimental Alzheimer's disease. Bulletin of experimental biology and medicine, 2013, Volume: 154, Issue:4 Topics: Administration, Intranasal; Alzheimer Disease; Animals; Antibodies; Caspase 3; Glutamic Acid; Male; Rats; Rats, Wistar	2013
Amyloid-β1-42 slows clearance of synaptically released glutamate by mislocalizing astrocytic GLT-1. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013, Mar-20, Volume: 33, Issue:12 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Astrocytes; Chromans; Drug Interactions; Excitatory Amino Acid Transporter 2; Extracellular Space; Female; Glutamic Acid; Hippocampus; Male; Mice; Mice, Inbred C57BL; Models, Neurological; Neurons; Organ Culture Techniques; Peptide Fragments; Synapses	2013
Mixed ligand Cu2+ complexes of a model therapeutic with Alzheimer's amyloid-β peptide and monoamine neurotransmitters. Inorganic chemistry, 2013, Apr-15, Volume: 52, Issue:8 Topics: Alzheimer Disease; Amyloid beta-Peptides; Copper; Glutamic Acid; Glutathione Disulfide; Glycine; Histamine; Histidine; Humans; Ligands; Models, Molecular; Neurotransmitter Agents; Oxyquinoline	2013
Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss. Proceedings of the National Academy of Sciences of the United States of America, 2013, Jul-02, Volume: 110, Issue:27 Topics: alpha7 Nicotinic Acetylcholine Receptor; Alzheimer Disease; Amyloid beta-Peptides; Animals; Astrocytes; Coculture Techniques; Female; Fluorescence Resonance Energy Transfer; Glutamic Acid; HEK293 Cells; Hippocampus; Humans; Male; Mice; Mice, Transgenic; Neural Inhibition; Peptide Fragments; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Nicotinic; Synapses	2013
S1 pocket of glutamate carboxypeptidase II: a new binding site for amyloid-β degradation. Biochemical and biophysical research communications, 2013, Sep-06, Volume: 438, Issue:4 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Binding Sites; Cell Line, Tumor; Dipeptides; Enzyme Inhibitors; Glutamate Carboxypeptidase II; Glutamic Acid; Humans; Mice; Mice, Transgenic; Molecular Docking Simulation; Mutagenesis, Site-Directed; Organophosphorus Compounds; Proteolysis	2013
Effects of Zn2+ binding on the structural and dynamic properties of amyloid β peptide associated with Alzheimer's disease: Asp1 or Glu11? ACS chemical neuroscience, 2013, Nov-20, Volume: 4, Issue:11 Topics: Alzheimer Disease; Amyloid beta-Peptides; Aspartic Acid; Glutamic Acid; Humans; Markov Chains; Models, Genetic; Molecular Dynamics Simulation; Nuclear Magnetic Resonance, Biomolecular; Protein Binding; Protein Conformation; Proteostasis Deficiencies; Structure-Activity Relationship; Zinc	2013
Combination of memantine and vitamin D prevents axon degeneration induced by amyloid-beta and glutamate. Neurobiology of aging, 2014, Volume: 35, Issue:2 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Axons; Cells, Cultured; Drug Synergism; Drug Therapy, Combination; Excitatory Amino Acid Antagonists; Glutamic Acid; Memantine; Mice; Nerve Degeneration; Neuroprotective Agents; Vitamin D	2014
Efficient derivation of cortical glutamatergic neurons from human pluripotent stem cells: a model system to study neurotoxicity in Alzheimer's disease. Neurobiology of disease, 2014, Volume: 62 Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Animals; Cell Death; Cells, Cultured; Cerebral Cortex; Female; GABAergic Neurons; Glutamic Acid; Hedgehog Proteins; Humans; Neurons; Pluripotent Stem Cells; Rats, Inbred F344	2014
Astrocytes and glutamate homoeostasis in Alzheimer's disease: a decrease in glutamine synthetase, but not in glutamate transporter-1, in the prefrontal cortex. ASN neuro, 2013, Oct-07, Volume: 5, Issue:4 Topics: Alzheimer Disease; Animals; Astrocytes; Disease Models, Animal; Excitatory Amino Acid Transporter 2; Glutamate-Ammonia Ligase; Glutamic Acid; Homeostasis; Male; Mice; Mice, Transgenic; Prefrontal Cortex	2013
Cerebral level of vGlut1 is increased and level of glycine is decreased in TgSwDI mice. Journal of Alzheimer's disease : JAD, 2014, Volume: 39, Issue:1 Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Autoradiography; Cerebellum; Cerebral Cortex; Disease Models, Animal; Disease Progression; Glutamic Acid; Glycine; Hippocampus; Mice; Mice, Inbred C57BL; Mice, Transgenic; Receptors, N-Methyl-D-Aspartate; Vesicular Glutamate Transport Protein 1	2014
1H NMR metabolomic signatures in five brain regions of the AβPPswe Tg2576 mouse model of Alzheimer's disease at four ages. Journal of Alzheimer's disease : JAD, 2014, Volume: 39, Issue:1 Topics: Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Biomarkers; Cerebellum; Cerebral Cortex; Disease Models, Animal; Genotype; Glutamic Acid; Hippocampus; Magnetic Resonance Spectroscopy; Male; Mesencephalon; Metabolome; Mice; Mice, Transgenic; Tissue Extracts	2014
R-flurbiprofen improves tau, but not Aß pathology in a triple transgenic model of Alzheimer's disease. Brain research, 2013, Dec-06, Volume: 1541 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Flurbiprofen; Glutamic Acid; Glutamine; Hippocampus; Humans; Immunohistochemistry; Magnetic Resonance Spectroscopy; Maze Learning; Mice; Mice, Transgenic; tau Proteins	2013
Reversal of metabolic deficits by lipoic acid in a triple transgenic mouse model of Alzheimer's disease: a 13C NMR study. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2014, Volume: 34, Issue:2 Topics: Alzheimer Disease; Animals; Aspartic Acid; Biomarkers; Citric Acid Cycle; gamma-Aminobutyric Acid; Glucose; Glutamic Acid; Glutamine; Humans; Mice; Mice, Transgenic; Thioctic Acid; Vitamin B Complex	2014
Neuropep-1 ameliorates learning and memory deficits in an Alzheimer's disease mouse model, increases brain-derived neurotrophic factor expression in the brain, and causes reduction of amyloid beta plaques. Neurobiology of aging, 2014, Volume: 35, Issue:5 Topics: 1-Methyl-4-phenylpyridinium; Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Brain-Derived Neurotrophic Factor; Cell Death; Cells, Cultured; Disease Models, Animal; Glutamic Acid; Humans; Learning; Memory; Mice; Molecular Targeted Therapy; Neurons; Neuroprotective Agents; Oligopeptides; Peptide Fragments; Plaque, Amyloid	2014
Hippocampal glutamate NMDA receptor loss tracks progression in Alzheimer's disease: quantitative autoradiography in postmortem human brain. PloS one, 2013, Volume: 8, Issue:11 Topics: Alzheimer Disease; Autoradiography; Disease Progression; Female; Glutamic Acid; Hippocampus; Humans; Male; Receptors, N-Methyl-D-Aspartate	2013
α7 Nicotinic receptor-mediated astrocytic gliotransmitter release: Aβ effects in a preclinical Alzheimer's mouse model. PloS one, 2013, Volume: 8, Issue:11 Topics: alpha7 Nicotinic Acetylcholine Receptor; Alzheimer Disease; Animals; Astrocytes; CA1 Region, Hippocampal; Calcium; Disease Models, Animal; Glutamic Acid; Male; Mice; Neuroglia; Neurotransmitter Agents; Rats; Rats, Wistar	2013
High-energy compounds mobilize intracellular Ca2+ and activate calpain in cultured cells: is calpain an energy-dependent protease? Brain research bulletin, 2014, Volume: 102 Topics: Acetyl Coenzyme A; Adenosine Triphosphate; Alzheimer Disease; Calcium; Calpain; Cell Line, Tumor; Chelating Agents; Cysteine Proteinase Inhibitors; Dipeptides; Egtazic Acid; Extracellular Space; Glutamic Acid; Humans; Intracellular Space; Nicotine; Nicotinic Agonists; Phosphocreatine; Phosphoenolpyruvate; Rotenone; Uncoupling Agents	2014
CHF5074 and LY450139 sub-acute treatments differently affect cortical extracellular glutamate levels in pre-plaque Tg2576 mice. Neuroscience, 2014, Apr-25, Volume: 266 Topics: Alanine; Alzheimer Disease; Animals; Azepines; Cyclopropanes; Disease Models, Animal; Extracellular Space; Female; Flurbiprofen; Glutamic Acid; Humans; Mice; Mice, Transgenic; Microdialysis; Neuroprotective Agents; Prefrontal Cortex; Synaptic Transmission	2014
1H-proton magnetic resonance spectroscopy differentiates dementia with Lewy bodies from Alzheimer's disease. Journal of Alzheimer's disease : JAD, 2014, Volume: 40, Issue:4 Topics: Activities of Daily Living; Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Aspartic Acid; Cerebral Cortex; Chi-Square Distribution; Female; Glutamic Acid; Humans; Lewy Body Disease; Linear Models; Magnetic Resonance Imaging; Male; Middle Aged; Proton Magnetic Resonance Spectroscopy; ROC Curve	2014
Neuronal and astrocytic metabolism in a transgenic rat model of Alzheimer's disease. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2014, Volume: 34, Issue:5 Topics: Alzheimer Disease; Animals; Astrocytes; Brain; Citric Acid Cycle; Disease Models, Animal; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Neurons; Pyruvic Acid; Rats; Rats, Transgenic; Rats, Wistar	2014
Alzheimer amyloid beta inhibition of Eg5/kinesin 5 reduces neurotrophin and/or transmitter receptor function. Neurobiology of aging, 2014, Volume: 35, Issue:8 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Calcium; Cells, Cultured; Cognition; Female; Glutamic Acid; Kinesins; Long-Term Potentiation; Memory; Mice; Mice, Transgenic; Molecular Targeted Therapy; Nerve Growth Factor; Nerve Growth Factors; Neurites; Neuronal Plasticity; PC12 Cells; Pregnancy; Pyrimidines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Thiones	2014
Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration in vivo. Brain : a journal of neurology, 2014, Volume: 137, Issue:Pt 5 Topics: alpha-Synuclein; Alzheimer Disease; Animals; Brain; Disease Models, Animal; Gene Expression Regulation; Glutamic Acid; Humans; Lewy Body Disease; Lysine; Memory Disorders; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Nerve Degeneration; Nerve Tissue Proteins; Neurons; Synapses; Thy-1 Antigens	2014
Plasma metabolite profiles of Alzheimer's disease and mild cognitive impairment. Journal of proteome research, 2014, May-02, Volume: 13, Issue:5 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Arachidonic Acid; Biomarkers; Chromatography, Liquid; Cognitive Dysfunction; Cytidine; Gas Chromatography-Mass Spectrometry; Glutamic Acid; Glutamine; Humans; Male; Mass Spectrometry; Metabolomics; Middle Aged; Reproducibility of Results; Sarcosine; Sensitivity and Specificity; Thymine	2014
Pyroglutamylated amyloid-β peptide reverses cross β-sheets by a prion-like mechanism. The journal of physical chemistry. B, 2014, May-29, Volume: 118, Issue:21 Topics: Alzheimer Disease; Amyloid beta-Peptides; Glutamic Acid; Humans; Models, Molecular; Prions; Protein Aggregates; Protein Aggregation, Pathological; Protein Structure, Secondary	2014
Glutamate and GABA-metabolizing enzymes in post-mortem cerebellum in Alzheimer's disease: phosphate-activated glutaminase and glutamic acid decarboxylase. Cerebellum (London, England), 2014, Volume: 13, Issue:5 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amide Synthases; Cerebellum; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamate Dehydrogenase; Glutamic Acid; Glutaminase; Humans; Middle Aged; Nerve Tissue Proteins	2014
Altered neurotransmission prior to cognitive decline in AβPP/PS1 mice, a model of Alzheimer's disease. Journal of Alzheimer's disease : JAD, 2015, Volume: 44, Issue:3 Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Cognition Disorders; Disease Models, Animal; Glutamic Acid; Humans; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Transgenic; Potassium Chloride; Presenilin-1; Synaptic Transmission	2015
Investigating dynamic structural and mechanical changes of neuroblastoma cells associated with glutamate-mediated neurodegeneration. Scientific reports, 2014, Nov-17, Volume: 4 Topics: Alzheimer Disease; Cell Line, Tumor; Glutamic Acid; Humans; Huntington Disease; Microscopy, Atomic Force; Nerve Degeneration; Neuroblastoma; Receptors, N-Methyl-D-Aspartate	2014
A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death. Nature medicine, 2014, Volume: 20, Issue:12 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Animals; CA3 Region, Hippocampal; Cell Death; Female; Genetic Predisposition to Disease; Glutamic Acid; HEK293 Cells; Humans; Male; Mice; Netrin Receptors; Neurons; Rats; Receptors, Cell Surface; Receptors, Nerve Growth Factor; Staurosporine	2014
A2A adenosine receptor deletion is protective in a mouse model of Tauopathy. Molecular psychiatry, 2016, Volume: 21, Issue:1 Topics: Adenosine A2 Receptor Antagonists; Alzheimer Disease; Animals; Cognition Disorders; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Humans; Long-Term Synaptic Depression; Mice, Transgenic; Phosphorylation; Receptor, Adenosine A2A; RNA, Messenger; tau Proteins; Tauopathies; Tissue Culture Techniques; Xanthines	2016
Erythropoietin improves synaptic plasticity and memory deficits by decrease of the neurotransmitter release probability in the rat model of Alzheimer's disease. Pharmacology, biochemistry, and behavior, 2015, Volume: 130 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Avoidance Learning; Disease Models, Animal; Erythropoietin; Excitatory Postsynaptic Potentials; Glutamic Acid; Hematocrit; Hippocampus; Long-Term Potentiation; Male; Memory Disorders; Neuronal Plasticity; Neuroprotective Agents; Peptide Fragments; Rats	2015
¹H- and ¹³C-NMR spectroscopy of Thy-1-APPSL mice brain extracts indicates metabolic changes in Alzheimer's disease. Journal of neural transmission (Vienna, Austria : 1996), 2015, Volume: 122, Issue:4 Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Brain; Carbon-13 Magnetic Resonance Spectroscopy; Creatine; Disease Models, Animal; Female; gamma-Aminobutyric Acid; Glucose; Glutamic Acid; Glutamine; Humans; Inositol; Male; Mice, Transgenic; Mutation; Peptide Fragments; Phosphorylcholine; Proton Magnetic Resonance Spectroscopy	2015
Differential Effects of Palmitoylethanolamide against Amyloid-β Induced Toxicity in Cortical Neuronal and Astrocytic Primary Cultures from Wild-Type and 3xTg-AD Mice. Journal of Alzheimer's disease : JAD, 2015, Volume: 46, Issue:2 Topics: Alzheimer Disease; Amides; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Astrocytes; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Ethanolamines; Glutamic Acid; Mice; Mice, Transgenic; Neurons; Palmitic Acids; tau Proteins	2015
Ceftriaxone ameliorates tau pathology and cognitive decline via restoration of glial glutamate transporter in a mouse model of Alzheimer's disease. Neurobiology of aging, 2015, Volume: 36, Issue:7 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Astrocytes; Brain; Ceftriaxone; Cells, Cultured; Disease Models, Animal; Excitatory Amino Acid Transporter 2; Glutamic Acid; Mice, Inbred C57BL; Mice, Transgenic; Neurons; tau Proteins; Up-Regulation	2015
Calcium flux-independent NMDA receptor activity is required for Aβ oligomer-induced synaptic loss. Cell death & disease, 2015, Jun-18, Volume: 6 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Calcium; Dendritic Spines; Dizocilpine Maleate; Egtazic Acid; Glutamic Acid; GTP-Binding Proteins; Hippocampus; Memantine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuroprotective Agents; p38 Mitogen-Activated Protein Kinases; Pertussis Toxin; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Valine	2015
Riluzole rescues glutamate alterations, cognitive deficits, and tau pathology associated with P301L tau expression. Journal of neurochemistry, 2015, Volume: 135, Issue:2 Topics: Alzheimer Disease; Animals; Brain Chemistry; Cognition Disorders; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Maze Learning; Mice; Mice, Transgenic; Neuroprotective Agents; Riluzole; Synapses; tau Proteins; Tauopathies; Vesicular Glutamate Transport Protein 1	2015
Substantial Neuroprotective and Neurite Outgrowth-Promoting Activities by Bis(propyl)-cognitin via the Activation of Alpha7-nAChR, a Promising Anti-Alzheimer's Dimer. ACS chemical neuroscience, 2015, Sep-16, Volume: 6, Issue:9 Topics: alpha7 Nicotinic Acetylcholine Receptor; Alzheimer Disease; Animals; Cell Death; Cells, Cultured; Cerebral Cortex; Enzyme Inhibitors; Glutamic Acid; MAP Kinase Signaling System; Neurites; Neurogenesis; Neurons; Neuroprotective Agents; PC12 Cells; Rats; Rats, Sprague-Dawley; Tacrine	2015
Conditioned medium from the stem cells of human dental pulp improves cognitive function in a mouse model of Alzheimer's disease. Behavioural brain research, 2015, Oct-15, Volume: 293 Topics: Administration, Intranasal; Alzheimer Disease; Amyloid beta-Peptides; Animals; Cell Survival; Cells, Cultured; Cerebral Cortex; Cognition Disorders; Culture Media, Conditioned; Cytokines; Dental Pulp; Disease Models, Animal; Embryo, Mammalian; Glutamic Acid; Humans; Intercellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Neurons; Peptide Fragments; Recognition, Psychology; Stem Cells	2015
Insulin Attenuates Beta-Amyloid-Associated Insulin/Akt/EAAT Signaling Perturbations in Human Astrocytes. Cellular and molecular neurobiology, 2016, Volume: 36, Issue:6 Topics: Alzheimer Disease; Amyloid beta-Peptides; Astrocytes; Cells, Cultured; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Humans; Insulin; Neurons; Peptide Fragments; Proto-Oncogene Proteins c-akt; Receptor, Insulin; Signal Transduction	2016
Protective effects of NMDA receptor antagonist, memantine, against senescence of PC12 cells: A possible role of nNOS and combined effects with donepezil. Experimental gerontology, 2015, Volume: 72 Topics: Aging; Alzheimer Disease; Animals; beta-Galactosidase; Cholinesterase Inhibitors; Cognition; Disease Models, Animal; Donepezil; Glutamic Acid; Hippocampus; Indans; Male; Maze Learning; Memantine; Memory; Mice; Neuronal Plasticity; Nitric Oxide Synthase Type I; PC12 Cells; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate	2015
Riluzole rescues alterations in rapid glutamate transients in the hippocampus of rTg4510 mice. Metabolic brain disease, 2016, Volume: 31, Issue:3 Topics: Alzheimer Disease; Animals; Disease Models, Animal; Glutamic Acid; Hippocampus; Memory Disorders; Mice; Mice, Transgenic; Neuroprotective Agents; Riluzole	2016
An integrative genome-wide transcriptome reveals that candesartan is neuroprotective and a candidate therapeutic for Alzheimer's disease. Alzheimer's research & therapy, 2016, Jan-28, Volume: 8 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Angiotensin II Type 1 Receptor Blockers; Animals; Apoptosis; Benzimidazoles; Biphenyl Compounds; Cells, Cultured; Cerebellum; Databases, Factual; Disease Models, Animal; Gene Expression Profiling; Glutamic Acid; Hippocampus; Humans; Inflammation Mediators; Neurons; Neuroprotective Agents; Rats, Sprague-Dawley; Signal Transduction; Tetrazoles; Transcriptome	2016
An Integrated Approach for Screening and Identification of Positive Allosteric Modulators of N-Methyl-D-Aspartate Receptors. Journal of biomolecular screening, 2016, Volume: 21, Issue:5 Topics: Allosteric Regulation; Alzheimer Disease; Calcium; Drug Discovery; Glutamic Acid; HEK293 Cells; High-Throughput Screening Assays; Humans; Neuronal Plasticity; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Small Molecule Libraries	2016
Learning impairment by minimal cortical injury in a mouse model of Alzheimer's disease. Brain research, 2016, Apr-15, Volume: 1637 Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain Injuries; Disease Models, Animal; Glutamic Acid; Hippocampus; Large-Conductance Calcium-Activated Potassium Channels; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurons; Neurotoxins; Parietal Lobe; Peptide Fragments; Plaque, Amyloid	2016
Age and Alzheimer's disease gene expression profiles reversed by the glutamate modulator riluzole. Molecular psychiatry, 2017, Volume: 22, Issue:2 Topics: Age Factors; Aging; Alzheimer Disease; Animals; Cognition; Cognitive Aging; Disease Models, Animal; Excitatory Amino Acid Transporter 2; Glutamic Acid; Hippocampus; Male; Memory; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Riluzole; Synaptic Transmission; Transcriptome	2017
Glutamine and Glutamate Complex, as Measured by Functional Magnetic Resonance Spectroscopy, Alters During Face-Name Association Task in Patients with Mild Cognitive Impairment and Alzheimer's Disease. Journal of Alzheimer's disease : JAD, 2016, 03-05, Volume: 52, Issue:1 Topics: Adult; Aged; Alzheimer Disease; Brain; Brain Mapping; Cognitive Dysfunction; Cohort Studies; Face; Female; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Mental Status Schedule; Names; Neuropsychological Tests; Pattern Recognition, Physiological; ROC Curve	2016
Apolipoprotein E4 (APOE4) Genotype Is Associated with Altered Levels of Glutamate Signaling Proteins and Synaptic Coexpression Networks in the Prefrontal Cortex in Mild to Moderate Alzheimer Disease. Molecular & cellular proteomics : MCP, 2016, Volume: 15, Issue:7 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Apolipoprotein E4; Down-Regulation; Female; Glutamic Acid; Humans; Male; Mass Spectrometry; Middle Aged; Prefrontal Cortex; Proteomics; Receptors, Glutamate; Signal Transduction; Synapses	2016
Down-regulation of glutamatergic terminals (VGLUT1) driven by Aβ in Alzheimer's disease. Hippocampus, 2016, Volume: 26, Issue:10 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Cells, Cultured; Disease Models, Animal; Glutamic Acid; Humans; Mice, Inbred C57BL; Mice, Transgenic; Neuronal Plasticity; Neurons; Plaque, Amyloid; Receptors, N-Methyl-D-Aspartate; Vesicular Glutamate Transport Protein 1	2016
Introduction of d-Glutamate at a Critical Residue of Aβ42 Stabilizes a Prefibrillary Aggregate with Enhanced Toxicity. Chemistry (Weinheim an der Bergstrasse, Germany), 2016, Aug-16, Volume: 22, Issue:34 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Glutamic Acid; Humans; PC12 Cells; Peptide Fragments; Rats	2016
Oligomers of Amyloid β Prevent Physiological Activation of the Cellular Prion Protein-Metabotropic Glutamate Receptor 5 Complex by Glutamate in Alzheimer Disease. The Journal of biological chemistry, 2016, 08-12, Volume: 291, Issue:33 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Disease Models, Animal; Female; Glutamic Acid; Male; Mice; Mice, Transgenic; Peptide Fragments; Protein Aggregation, Pathological; PrPC Proteins; Receptor, Metabotropic Glutamate 5	2016
Peripheral Interventions Enhancing Brain Glutamate Homeostasis Relieve Amyloid β- and TNFα- Mediated Synaptic Plasticity Disruption in the Rat Hippocampus. Cerebral cortex (New York, N.Y. : 1991), 2017, 07-01, Volume: 27, Issue:7 Topics: Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Animals; Aspartate Aminotransferase, Cytoplasmic; Aspartic Acid; Excitatory Postsynaptic Potentials; Female; Glutamic Acid; Hippocampus; Homeostasis; Humans; Injections, Intraperitoneal; Male; Oxaloacetic Acid; Peptide Fragments; Rats; Rats, Wistar; Synapses; Time Factors; Tumor Necrosis Factor-alpha	2017
Involvement of hippocampal excitability in amyloid β-induced behavioral and psychological symptoms of dementia. The Journal of toxicological sciences, 2016, Volume: 41, Issue:4 Topics: Aggression; Alzheimer Disease; Amyloid beta-Peptides; Animals; Anxiety; Behavior, Animal; Cognition; Cognition Disorders; Corticosterone; Disease Models, Animal; Glutamic Acid; Hippocampus; Housing, Animal; In Vitro Techniques; Male; Maze Learning; Mice; Motor Activity; Peptide Fragments; Recognition, Psychology; Social Isolation; Synaptic Transmission; Time Factors	2016
Age-dependent changes in the glutamate-nitric oxide pathway in the hippocampus of the triple transgenic model of Alzheimer's disease: implications for neurometabolic regulation. Neurobiology of aging, 2016, Volume: 46 Topics: Aging; Alzheimer Disease; Animals; Disease Models, Animal; Energy Metabolism; Glutamic Acid; Hippocampus; Mice, Transgenic; Microelectrodes; Mitochondria; Neurotransmitter Agents; Nitric Oxide; Oxidative Phosphorylation; Oxygen Consumption; Peroxynitrous Acid; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Tyrosine	2016
β-Secretase (BACE1) inhibitory and neuroprotective effects of p-terphenyls from Polyozellus multiplex. Food & function, 2016, Sep-14, Volume: 7, Issue:9 Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Basidiomycota; Cell Death; Cell Line, Tumor; Enzyme Inhibitors; Furans; Glutamic Acid; Humans; Mice; Neuroblastoma; Neuroprotective Agents; Republic of Korea; Terphenyl Compounds; Transfection	2016
Synthesis and evaluation of multifunctional ferulic and caffeic acid dimers for Alzheimer's disease. Natural product research, 2017, Volume: 31, Issue:6 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Biphenyl Compounds; Caffeic Acids; Cell Death; Cell Line; Coumaric Acids; Free Radical Scavengers; Glutamic Acid; Humans; Mice; Neurons; Peptide Fragments; Picrates	2017
Inhibiting tumor necrosis factor-α before amyloidosis prevents synaptic deficits in an Alzheimer's disease model. Neurobiology of aging, 2016, Volume: 47 Topics: Alzheimer Disease; Animals; Disease Models, Animal; Glutamic Acid; Hippocampus; Mice, Transgenic; Molecular Targeted Therapy; Neuronal Plasticity; Plaque, Amyloid; Synapses; Synaptic Transmission; Tumor Necrosis Factor-alpha	2016
Whole-brain patterns of (1)H-magnetic resonance spectroscopy imaging in Alzheimer's disease and dementia with Lewy bodies. Translational psychiatry, 2016, 08-30, Volume: 6, Issue:8 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain; Case-Control Studies; Choline; Creatine; Female; Glutamic Acid; Glutamine; Humans; Inositol; Lewy Body Disease; Magnetic Resonance Imaging; Male; Proton Magnetic Resonance Spectroscopy	2016
VRK3-mediated nuclear localization of HSP70 prevents glutamate excitotoxicity-induced apoptosis and Aβ accumulation via enhancement of ERK phosphatase VHR activity. Scientific reports, 2016, 12-12, Volume: 6 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Apoptosis; Brain; Cell Line, Tumor; Cell Nucleus; Dual Specificity Phosphatase 3; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Glutamic Acid; HSP70 Heat-Shock Proteins; Humans; Mice, Inbred C57BL; Neurons; Neuroprotective Agents; Neurotoxins; Parkinson Disease; Protein Binding; Protein Serine-Threonine Kinases; Protein Transport	2016
Prokineticin system modulation as a new target to counteract the amyloid beta toxicity induced by glutamatergic alterations in an in vitro model of Alzheimer's disease. Neuropharmacology, 2017, Volume: 116 Topics: Alzheimer Disease; Amphibian Proteins; Amyloid beta-Peptides; Animals; Anura; Cell Survival; Cells, Cultured; Cerebral Cortex; Gastrointestinal Hormones; Glutamic Acid; Indoles; Maleimides; Neurons; Neuropeptides; Neuroprotective Agents; Protein Kinase C; Protein Kinase Inhibitors; Rats, Wistar; Receptors, AMPA; Receptors, G-Protein-Coupled; Receptors, Peptide; Synaptic Transmission	2017
Numerical Simulations Reveal Randomness of Cu(II) Induced Aβ Peptide Dimerization under Conditions Present in Glutamatergic Synapses. PloS one, 2017, Volume: 12, Issue:1 Topics: Alzheimer Disease; Amyloid beta-Peptides; Computer Simulation; Copper; Glutamic Acid; Humans; Models, Statistical; Peptide Fragments; Protein Multimerization; Solutions; Stochastic Processes; Synapses	2017
Neurovascular uncoupling in the triple transgenic model of Alzheimer's disease: Impaired cerebral blood flow response to neuronal-derived nitric oxide signaling. Experimental neurology, 2017, Volume: 291 Topics: Adenosine Diphosphate; Age Factors; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Body Weight; Cerebrovascular Circulation; Disease Models, Animal; Excitatory Amino Acid Agonists; Glutamic Acid; Humans; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Neurovascular Coupling; Nitric Oxide; Nitric Oxide Synthase Type I; Presenilin-1; Signal Transduction; tau Proteins	2017
Neuronally-directed effects of RXR activation in a mouse model of Alzheimer's disease. Scientific reports, 2017, 02-16, Volume: 7 Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Bexarotene; Biomarkers; Cell Survival; Cytokines; Disease Models, Animal; Female; Gliosis; Glutamic Acid; Habituation, Psychophysiologic; Hippocampus; Inflammation; Male; Membrane Transport Proteins; Memory; Mice, Transgenic; Neurons; Neurotoxins; Olfactory Bulb; Plaque, Amyloid; Receptors, LDL; Retinoid X Receptors; Synapses; Tetrahydronaphthalenes	2017
Immunological alteration & toxic molecular inductions leading to cognitive impairment & neurotoxicity in transgenic mouse model of Alzheimer's disease. Life sciences, 2017, May-15, Volume: 177 Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Cognition Disorders; Cytokines; Disease Models, Animal; Flow Cytometry; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Inflammation; Male; Memory Disorders; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuronal Plasticity; Oxidative Stress	2017
Medial septal beta-amyloid 1-40 injections alter septo-hippocampal anatomy and function. Neurobiology of aging, 2010, Volume: 31, Issue:1 Topics: Acetylcholine; Action Potentials; Alzheimer Disease; Amyloid beta-Peptides; Animals; Cholinergic Fibers; Disease Models, Animal; Glutamic Acid; Hippocampus; Male; Nerve Degeneration; Neural Pathways; Neurons; Peptide Fragments; Rats; Rats, Sprague-Dawley; Septal Nuclei; Theta Rhythm	2010
Endogenous secreted amyloid precursor protein-alpha regulates hippocampal NMDA receptor function, long-term potentiation and spatial memory. Neurobiology of disease, 2008, Volume: 31, Issue:2 Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Antibodies; Dipeptides; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glutamic Acid; Hippocampus; Hydroxamic Acids; Long-Term Potentiation; Male; Memory; Memory Disorders; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Recombinant Fusion Proteins; Space Perception; Synaptic Transmission	2008
Relationships between expression of apolipoprotein E and beta-amyloid precursor protein are altered in proximity to Alzheimer beta-amyloid plaques: potential explanations from cell culture studies. Journal of neuropathology and experimental neurology, 2008, Volume: 67, Issue:8 Topics: Adult; Age Factors; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Animals, Newborn; Apolipoproteins E; Brain; Cells, Cultured; Dose-Response Relationship, Drug; Female; Gene Expression Regulation; Glutamic Acid; Humans; Male; Middle Aged; Neocortex; Neurons; Plaque, Amyloid; Rats; RNA, Small Interfering	2008
Episodic memory deficits are not related to altered glutamatergic synaptic transmission and plasticity in the CA1 hippocampus of the APPswe/PS1δE9-deleted transgenic mice model of ß-amyloidosis. Neurobiology of aging, 2010, Volume: 31, Issue:7 Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloidosis; Animals; CA1 Region, Hippocampal; Disease Models, Animal; Female; Glutamic Acid; Memory Disorders; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Neuronal Plasticity; Organ Culture Techniques; Presenilin-1; Presynaptic Terminals; Synaptic Transmission	2010
ß-amyloid-related peptides potentiate K+-evoked glutamate release from adult rat hippocampal slices. Neurobiology of aging, 2010, Volume: 31, Issue:7 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Glutamic Acid; Hippocampus; Male; Organ Culture Techniques; Peptide Fragments; Potassium; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Vesicular Glutamate Transport Protein 1	2010
[Paradoxical increase in glutamatergic synaptic terminations in mild cognitive impairment due to Alzheimer's disease]. Medecine sciences : M/S, 2008, Volume: 24, Issue:10 Topics: Alzheimer Disease; Animals; Cognition Disorders; Female; Frontal Lobe; Glutamic Acid; Humans; Male; Mice; Mice, Transgenic; Middle Aged; Nerve Tissue Proteins; Neurites; Presynaptic Terminals; Receptors, Glutamate; Receptors, Presynaptic; Synaptic Transmission	2008
Association between NR2B subunit gene (GRIN2B) promoter polymorphisms and sporadic Alzheimer's disease in the North Chinese population. Neuroscience letters, 2009, Feb-06, Volume: 450, Issue:3 Topics: Aged; Alzheimer Disease; Apolipoproteins E; Asian People; Brain; Brain Chemistry; DNA Mutational Analysis; Female; Gene Frequency; Genetic Markers; Genetic Predisposition to Disease; Genetic Testing; Genotype; Glutamic Acid; HeLa Cells; Humans; Male; Middle Aged; Polymorphism, Genetic; Promoter Regions, Genetic; Receptors, N-Methyl-D-Aspartate	2009
Minocycline reduces the development of abnormal tau species in models of Alzheimer's disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2009, Volume: 23, Issue:3 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Caspase 3; Cell Death; Cells, Cultured; Glutamic Acid; Humans; Mice; Mice, Transgenic; Minocycline; Neurons; Rats; Staurosporine; tau Proteins; Time Factors	2009
Brain metabolism differs in Alzheimer's disease and Parkinson's disease dementia. Alzheimer's & dementia : the journal of the Alzheimer's Association, 2008, Volume: 4, Issue:6 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Aspartic Acid; Case-Control Studies; Choline; Creatine; Glutamic Acid; Gyrus Cinguli; Humans; Magnetic Resonance Spectroscopy; Male; Mental Status Schedule; Middle Aged; Nootropic Agents; Parkinson Disease	2008
Memantine protects rat cortical cultured neurons against beta-amyloid-induced toxicity by attenuating tau phosphorylation. The European journal of neuroscience, 2008, Volume: 28, Issue:10 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Caspase 3; Cells, Cultured; Cerebral Cortex; Cyclic AMP Response Element-Binding Protein; Enzyme Activation; Excitatory Amino Acid Antagonists; Extracellular Fluid; Glutamic Acid; Memantine; Neurons; Neuroprotective Agents; Peptide Fragments; Phosphorylation; Phosphotransferases; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; tau Proteins; Up-Regulation	2008
Effect of a dominant-negative form of ADAM10 in a mouse model of Alzheimer's disease. Journal of Alzheimer's disease : JAD, 2009, Volume: 16, Issue:2 Topics: ADAM Proteins; ADAM10 Protein; Age Factors; Alanine; Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Behavior, Animal; Disease Models, Animal; Glutamic Acid; Humans; Isoleucine; Maze Learning; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Reaction Time; Swimming; Valine	2009
Calpain hydrolysis of alpha- and beta2-adaptins decreases clathrin-dependent endocytosis and may promote neurodegeneration. The Journal of biological chemistry, 2009, May-01, Volume: 284, Issue:18 Topics: Adaptor Protein Complex alpha Subunits; Adaptor Protein Complex beta Subunits; Adaptor Proteins, Vesicular Transport; Alzheimer Disease; Animals; Brain; Brain Ischemia; Calcium; Calpain; Cell Line; Cell Membrane; Clathrin; Endocytosis; Female; Glutamic Acid; Humans; Hydrolysis; Male; Membrane Lipids; Monomeric Clathrin Assembly Proteins; Neurons; Rats; Rats, Sprague-Dawley; Rats, Wistar	2009
A role for synaptic zinc in activity-dependent Abeta oligomer formation and accumulation at excitatory synapses. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009, Apr-01, Volume: 29, Issue:13 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Calmodulin-Binding Proteins; Carrier Proteins; Cation Transport Proteins; Cells, Cultured; Drug Interactions; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Hippocampus; Humans; In Vitro Techniques; Membrane Proteins; Membrane Transport Proteins; Mice; Mice, Knockout; Neurons; Potassium Chloride; Rats; Rats, Sprague-Dawley; Synapses; Synaptophysin; Tetrodotoxin; Time Factors; Zinc	2009
Oligomeric amyloid beta-protein as a therapeutic target in Alzheimer's disease: its significance based on its distinct localization and the occurrence of a familial variant form. Current Alzheimer research, 2009, Volume: 6, Issue:2 Topics: Alanine; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antibodies; Antibody Specificity; Glutamic Acid; Humans; Mice; Mutation; Peptide Fragments; Protein Conformation; Temporal Lobe	2009
Reduced hippocampal glutamate in Alzheimer disease. Neurobiology of aging, 2011, Volume: 32, Issue:5 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Biomarkers; Choline; Creatine; Female; Glutamic Acid; Hippocampus; Humans; Inositol; Magnetic Resonance Spectroscopy; Male	2011
Production of autoantibodies to glutamate during Alzheimer's dementia. Bulletin of experimental biology and medicine, 2009, Volume: 147, Issue:4 Topics: Age of Onset; Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Autoantibodies; Enzyme-Linked Immunosorbent Assay; Female; Glutamic Acid; Humans	2009
Conformational changes specific for pseudophosphorylation at serine 262 selectively impair binding of tau to microtubules. Biochemistry, 2009, Oct-27, Volume: 48, Issue:42 Topics: Alzheimer Disease; Binding Sites; Circular Dichroism; Glutamic Acid; Humans; Magnetic Resonance Spectroscopy; Microtubules; Models, Molecular; Mutation; Phosphorylation; Protein Conformation; Serine; tau Proteins	2009
Cognitive decline in Alzheimer's disease is associated with selective changes in calcineurin/NFAT signaling. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009, Oct-14, Volume: 29, Issue:41 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Analysis of Variance; Animals; Astrocytes; Brain; Calcineurin; Cells, Cultured; Cognition Disorders; Embryo, Mammalian; Female; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Glutamic Acid; Green Fluorescent Proteins; Hippocampus; Humans; Male; NFATC Transcription Factors; Peptide Fragments; Protein Transport; Rats; Signal Transduction; Transfection	2009
Aberrant modulation of a delayed rectifier potassium channel by glutamate in Alzheimer's disease. Neurobiology of disease, 2010, Volume: 37, Issue:2 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain Infarction; Cell Membrane; Cell Proliferation; Cells, Cultured; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Humans; Ion Channel Gating; Kv1.3 Potassium Channel; Lymphocyte Activation; Male; Membrane Potentials; Mitogens; Neuroimmunomodulation; Patch-Clamp Techniques; Phytohemagglutinins; Receptors, Metabotropic Glutamate; T-Lymphocytes	2010
Neuroprotective and cholinergic properties of multifunctional glutamic acid derivatives for the treatment of Alzheimer's disease. Journal of medicinal chemistry, 2009, Nov-26, Volume: 52, Issue:22 Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Catalytic Domain; Cattle; Cell Death; Cell Line, Tumor; Cell Survival; Cholinergic Agents; Cholinesterase Inhibitors; Esters; Glutamic Acid; Humans; Hydrophobic and Hydrophilic Interactions; Neuroprotective Agents; Permeability; Piperidines; Protein Binding	2009
The specificity of neuroprotection by antioxidants. Journal of biomedical science, 2009, Nov-05, Volume: 16 Topics: Alzheimer Disease; Animals; Antioxidants; Cell Survival; Fluorescent Dyes; Glutamic Acid; Membrane Potentials; Mice; Microscopy, Fluorescence; Mitochondria; Neuroprotective Agents; Oxygen; Parkinson Disease; Phosphorylation; Reactive Oxygen Species	2009
Up-regulation of the type 3 ryanodine receptor is neuroprotective in the TgCRND8 mouse model of Alzheimer's disease. Journal of neurochemistry, 2010, Volume: 112, Issue:2 Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Calcium; Cell Death; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Glutamic Acid; Green Fluorescent Proteins; Humans; Mice; Mice, Transgenic; Mutation; Neurons; Peptide Fragments; Phosphopyruvate Hydratase; Potassium; Presenilin-1; RNA, Messenger; RNA, Small Interfering; Ryanodine Receptor Calcium Release Channel; Tetrazolium Salts; Thiazoles; Up-Regulation	2010
GluN2B subunit-containing NMDA receptor antagonists prevent Abeta-mediated synaptic plasticity disruption in vivo. Proceedings of the National Academy of Sciences of the United States of America, 2009, Dec-01, Volume: 106, Issue:48 Topics: Alzheimer Disease; Amyloid beta-Peptides; Analysis of Variance; Animals; Dose-Response Relationship, Drug; Electrophysiology; Glutamic Acid; Hippocampus; Male; Memantine; Neuronal Plasticity; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synapses; Tumor Necrosis Factor-alpha	2009
Profile for amyloid-beta and tau expression in primary cortical cultures from 3xTg-AD mice. Cellular and molecular neurobiology, 2010, Volume: 30, Issue:4 Topics: Acetylcholine; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Calcium; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Glutamic Acid; Homeostasis; Humans; Mice; Mice, Transgenic; Neurons; Phosphorylation; tau Proteins	2010
Increased expression of cholesterol 24S-hydroxylase results in disruption of glial glutamate transporter EAAT2 association with lipid rafts: a potential role in Alzheimer's disease. Journal of neurochemistry, 2010, Volume: 113, Issue:4 Topics: Aged; Alzheimer Disease; Astrocytes; Brain; Brain Chemistry; Cholesterol; Cholesterol 24-Hydroxylase; Excitatory Amino Acid Transporter 2; Glutamic Acid; Humans; Membrane Microdomains; Steroid Hydroxylases; Up-Regulation	2010
Cdk5 is a major regulator of p38 cascade: relevance to neurotoxicity in Alzheimer's disease. Journal of neurochemistry, 2010, Volume: 113, Issue:5 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Blotting, Western; Calpain; Coloring Agents; Cyclin-Dependent Kinase 5; Glutamic Acid; Humans; Immunohistochemistry; MAP Kinase Kinase 6; Mice; Mice, Transgenic; Neurons; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction; Tetrazolium Salts; Thiazoles	2010
H2O2 and PAF mediate Abeta1-42-induced Ca2+ dyshomeostasis that is blocked by EGb761. Neurochemistry international, 2010, Volume: 56, Issue:8 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Calcium; Calcium Signaling; Cells, Cultured; Ginkgo biloba; Glutamic Acid; Hippocampus; Homeostasis; Hydrogen Peroxide; Neurons; Oxidative Stress; Peptide Fragments; Plant Extracts; Platelet Activating Factor; Rats; Rats, Sprague-Dawley	2010
Glutamate transporter variants reduce glutamate uptake in Alzheimer's disease. Neurobiology of aging, 2011, Volume: 32, Issue:3 Topics: Alzheimer Disease; Animals; Autopsy; Bacterial Proteins; Cell Line, Transformed; Cerebral Cortex; Excitatory Amino Acid Transporter 2; Exons; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Humans; Luminescent Proteins; Membrane Potentials; Oocytes; RNA Splicing; RNA, Messenger; Transfection; Xenopus laevis	2011
Simultaneous determination of biomarkers for Alzheimer's disease using sol-gel-derived optical array biosensor. Biosensors & bioelectronics, 2010, Jul-15, Volume: 25, Issue:11 Topics: Acetylcholine; Alzheimer Disease; Amyloid beta-Peptides; Biomarkers; Biosensing Techniques; Blood Chemical Analysis; Equipment Design; Equipment Failure Analysis; Glutamic Acid; Humans; Microarray Analysis; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Fluorescence	2010
Disruption of neuronal-glial-vascular units in the hippocampus of ovariectomized mice injected with D-galactose. Neuroscience, 2010, Aug-25, Volume: 169, Issue:2 Topics: Alzheimer Disease; Animals; Aquaporin 4; Biological Transport; Cell Communication; Connexin 43; Disease Models, Animal; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Galactose; Giant Cells; Glial Fibrillary Acidic Protein; Glutamate-Ammonia Ligase; Glutamic Acid; Hippocampus; Mice; Microvessels; Neuroglia; Neurons; Ovariectomy; Water	2010
Transgenic mice with chronic NGF deprivation and Alzheimer's disease-like pathology display hippocampal region-specific impairments in short- and long-term plasticities. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010, Sep-29, Volume: 30, Issue:39 Topics: Alzheimer Disease; Animals; Disease Models, Animal; Glutamic Acid; Hippocampus; Memory Disorders; Mesencephalon; Mice; Mice, Transgenic; Nerve Growth Factor; Neuronal Plasticity; Organ Culture Techniques; Perforant Pathway; Synaptic Transmission	2010
Amyloid-β decreases nitric oxide production in cultured retinal neurons: a possible mechanism for synaptic dysfunction in Alzheimer's disease? Neurochemical research, 2011, Volume: 36, Issue:1 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cells, Cultured; Chick Embryo; Enzyme Inhibitors; Glutamic Acid; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Peptide Fragments; Retina; Synapses	2011
Cleavage of Tau by calpain in Alzheimer's disease: the quest for the toxic 17 kD fragment. Neurobiology of aging, 2011, Volume: 32, Issue:1 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Animals; Calmodulin-Binding Proteins; Calpain; Cell Count; Cerebral Cortex; Cricetinae; Cricetulus; Embryo, Mammalian; Enzyme Inhibitors; Glutamic Acid; Green Fluorescent Proteins; Humans; In Situ Nick-End Labeling; Molecular Weight; Mutation; Neurons; Peptide Fragments; Peptides; Phosphorylation; Rats; tau Proteins; Thapsigargin; Transfection	2011
Proteolysis of calcineurin is increased in human hippocampus during mild cognitive impairment and is stimulated by oligomeric Abeta in primary cell culture. Aging cell, 2011, Volume: 10, Issue:1 Topics: Aged, 80 and over; Aging; Alzheimer Disease; Amyloid beta-Peptides; Animals; Calcineurin; Calcineurin Inhibitors; Calcium; Calpain; Case-Control Studies; Cell Culture Techniques; Cell Fractionation; Cognition Disorders; Disease Progression; Enzyme Activation; Enzyme Inhibitors; Female; Glutamic Acid; Hippocampus; Humans; Male; Peptide Fragments; Rats; Receptors, N-Methyl-D-Aspartate; Retrospective Studies; Signal Transduction	2011
Reactive astrocytes give neurons less support: implications for Alzheimer's disease. Neurobiology of aging, 2012, Volume: 33, Issue:2 Topics: Alzheimer Disease; Animals; Astrocytes; Brain; Cell Communication; Glucose; Glutamic Acid; Glutamine; Humans; Models, Neurological; Neurons	2012
Antiamnestic effects of antibodies to glutamate in experimental Alzheimer's disease. Bulletin of experimental biology and medicine, 2010, Volume: 150, Issue:1 Topics: Administration, Intranasal; Alzheimer Disease; Amnesia; Amyloid beta-Peptides; Animals; Antibodies; Avoidance Learning; Glutamic Acid; Male; Memory, Long-Term; Rats; Rats, Wistar	2010
[Effects of wide band frequency noise on ERK, GDNF and ABR threshold in the different area of brain of AD rats poisoned by glutamatic acid]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology, 2002, Volume: 18, Issue:4 Topics: Acoustic Stimulation; Alzheimer Disease; Animals; Auditory Threshold; Disease Models, Animal; Evoked Potentials, Auditory, Brain Stem; Extracellular Signal-Regulated MAP Kinases; Female; Glial Cell Line-Derived Neurotrophic Factor; Glutamic Acid; Male; Noise; Rats; Rats, Sprague-Dawley	2002
Alzheimer's Aβ peptides with disease-associated N-terminal modifications: influence of isomerisation, truncation and mutation on Cu2+ coordination. PloS one, 2010, Dec-30, Volume: 5, Issue:12 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Copper; Disease Progression; Electron Spin Resonance Spectroscopy; Glutamic Acid; Humans; Hydrogen-Ion Concentration; Ligands; Mice; Mutation; Oxidation-Reduction; Protein Binding; Protein Structure, Tertiary; Stereoisomerism	2010
Region- and age-specific changes in glutamate transport in the AβPP23 mouse model for Alzheimer's disease. Journal of Alzheimer's disease : JAD, 2011, Volume: 24, Issue:2 Topics: Aging; Alzheimer Disease; Amino Acid Transport System X-AG; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Cerebral Cortex; Chromatography, High Pressure Liquid; Disease Models, Animal; Excitatory Amino Acid Transporter 2; Gene Expression Regulation; Glutamic Acid; Hippocampus; Humans; Mice; Mice, Transgenic; Mutation	2011
Nuclear envelope dispersion triggered by deregulated Cdk5 precedes neuronal death. Molecular biology of the cell, 2011, Volume: 22, Issue:9 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cell Death; Cyclin-Dependent Kinase 5; Disease Models, Animal; Glutamic Acid; JNK Mitogen-Activated Protein Kinases; Lamin Type A; Lamin Type B; Mice; Mice, Transgenic; Mutation; Nerve Tissue Proteins; Neurofibrillary Tangles; Neurons; Nuclear Envelope; Nuclear Lamina; Phosphorylation; Phosphotransferases; Rats; Rats, Sprague-Dawley	2011
[About the NMDA-system again]. Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology, 2011, Volume: 13, Issue:1 Topics: Alcoholism; Alzheimer Disease; Animals; Antipsychotic Agents; Excitatory Amino Acid Agonists; Glutamic Acid; Humans; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Synapses	2011
Preferential accumulation of amyloid-beta in presynaptic glutamatergic terminals (VGluT1 and VGluT2) in Alzheimer's disease cortex. Neurobiology of disease, 2012, Volume: 45, Issue:1 Topics: Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Cerebral Cortex; Female; Glutamic Acid; Humans; Male; Presynaptic Terminals; Synaptosomes; Vesicular Glutamate Transport Protein 1; Vesicular Glutamate Transport Protein 2	2012
Brain glutamate levels are decreased in Alzheimer's disease: a magnetic resonance spectroscopy study. American journal of Alzheimer's disease and other dementias, 2011, Volume: 26, Issue:6 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Choline; Cognitive Dysfunction; Creatine; Cross-Sectional Studies; Female; Glutamic Acid; Gyrus Cinguli; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Protons; Severity of Illness Index	2011
Truncation of tau at E391 promotes early pathologic changes in transgenic mice. Journal of neuropathology and experimental neurology, 2011, Volume: 70, Issue:11 Topics: Adenosine Triphosphatases; Alzheimer Disease; Animals; Brain; Cation Transport Proteins; Copper-Transporting ATPases; Disease Models, Animal; Gene Expression Regulation; Glutamic Acid; Humans; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Neurons; Phosphorylation; Plaque, Amyloid; tau Proteins	2011
Multi-faced neuroprotective effects of Ginsenoside Rg1 in an Alzheimer mouse model. Biochimica et biophysica acta, 2012, Volume: 1822, Issue:2 Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Cerebellum; Cognition; Cognition Disorders; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Ginsenosides; Glutamic Acid; Humans; Learning; Memory; Mice; Mice, Transgenic; Neurons; Neuroprotective Agents; Phosphorylation	2012
Glutamatergic alterations and mitochondrial impairment in a murine model of Alzheimer disease. Neurobiology of aging, 2012, Volume: 33, Issue:6 Topics: Alzheimer Disease; Animals; Disease Models, Animal; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Glutamic Acid; Male; Mice; Mice, Transgenic; Mitochondria; Synaptosomal-Associated Protein 25; Vesicular Glutamate Transport Protein 1	2012
Impaired glutamatergic and GABAergic function at early age in AβPPswe-PS1dE9 mice: implications for Alzheimer's disease. Journal of Alzheimer's disease : JAD, 2012, Volume: 28, Issue:4 Topics: Age Factors; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamic Acid; Mice; Mice, Transgenic; Presenilin-1	2012
N-acetylaspartate, choline, myoinositol, glutamine and glutamate (glx) concentration changes in proton MR spectroscopy (1H MRS) in patients with mild cognitive impairment (MCI). Medical science monitor : international medical journal of experimental and clinical research, 2011, Volume: 17, Issue:12 Topics: Aged; Alzheimer Disease; Aspartic Acid; Choline; Cognitive Dysfunction; Disease Progression; Female; Glutamic Acid; Glutamine; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Middle Aged; Protons; Temporal Lobe	2011
Dual task abilities as a possible preclinical marker of Alzheimer's disease in carriers of the E280A presenilin-1 mutation. Journal of the International Neuropsychological Society : JINS, 2012, Volume: 18, Issue:2 Topics: Adult; Alanine; Alzheimer Disease; Analysis of Variance; Biomarkers; Cognition Disorders; Female; Glutamic Acid; Humans; Male; Mental Recall; Middle Aged; Mutation; Neuropsychological Tests; Presenilin-1; Regression Analysis; ROC Curve; Statistics, Nonparametric	2012
Glutamate-based depression GBD. Medical hypotheses, 2012, Volume: 78, Issue:5 Topics: Affect; Alzheimer Disease; Arthritis, Rheumatoid; Chronic Pain; Cognition; Coronary Artery Disease; Depression; Diabetes Complications; Fibromyalgia; Glutamic Acid; Gyrus Cinguli; Humans; Huntington Disease; Inflammation; Interferons; Models, Neurological; Models, Psychological; Parkinson Disease; Receptors, N-Methyl-D-Aspartate; Risk Factors; Stroke; Synaptic Transmission	2012
Lipocalin 2: novel component of proinflammatory signaling in Alzheimer's disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2012, Volume: 26, Issue:7 Topics: Acute-Phase Proteins; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Animals; Base Sequence; Brain; Case-Control Studies; Cells, Cultured; Cognitive Dysfunction; Female; Gene Expression; Glutamic Acid; Humans; Inflammation Mediators; Lipocalin-2; Lipocalins; Male; Mice; Models, Neurological; Neurons; Oligonucleotide Array Sequence Analysis; Oncogene Proteins; Proto-Oncogene Proteins; Receptors, Tumor Necrosis Factor, Type I; Receptors, Tumor Necrosis Factor, Type II; RNA, Messenger; Signal Transduction; Tumor Necrosis Factor-alpha	2012
Evidence supporting the role of calpain in the α-processing of amyloid-β precursor protein. Biochemical and biophysical research communications, 2012, Apr-13, Volume: 420, Issue:3 Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Biotinylation; Calpain; Cell Membrane; Genetic Vectors; Glutamic Acid; HEK293 Cells; Humans; Nicotine; Phorbol 12,13-Dibutyrate; Substrate Specificity	2012
Excitability and synaptic alterations in the cerebellum of APP/PS1 mice. PloS one, 2012, Volume: 7, Issue:4 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cerebellum; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamic Acid; Interneurons; Mice; Mice, Transgenic; Purkinje Cells; Synaptic Transmission	2012
Pretreatment with memantine prevents Alzheimer-like alterations induced by intrahippocampal okadaic acid administration in rats. Current Alzheimer research, 2012, Volume: 9, Issue:10 Topics: Alzheimer Disease; Animals; Carcinogens; Chromatography, High Pressure Liquid; Cyclin-Dependent Kinase 5; Disease Models, Animal; Drug Administration Schedule; Excitatory Amino Acid Antagonists; Exploratory Behavior; Glutamic Acid; Hippocampus; Locomotion; Male; Maze Learning; Memantine; Okadaic Acid; Rats; Rats, Wistar; Signal Transduction; Statistics as Topic; tau Proteins	2012
Dynein and dynactin components modulate neurodegeneration induced by excitotoxicity. Journal of neurochemistry, 2012, Volume: 122, Issue:1 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Animals; Antibodies, Monoclonal; Apoptosis; Axons; Cells, Cultured; Dynactin Complex; Dyneins; Embryo, Mammalian; Excitatory Amino Acids; Female; Frontal Lobe; Gene Expression Regulation; Glutamic Acid; Green Fluorescent Proteins; Hippocampus; Humans; Male; Microtubule-Associated Proteins; Mutation; Nerve Degeneration; Neurons; Protein Transport; Rats; Rats, Wistar; RNA, Small Interfering; Transfection	2012
Solid-state NMR reveals a close structural relationship between amyloid-β protofibrils and oligomers. The Journal of biological chemistry, 2012, Jun-29, Volume: 287, Issue:27 Topics: Alzheimer Disease; Amyloid beta-Peptides; Glutamic Acid; Humans; Hydrogen Bonding; Isoleucine; Models, Chemical; Neurofibrillary Tangles; Nuclear Magnetic Resonance, Biomolecular; Protein Structure, Secondary; Protein Structure, Tertiary	2012
Rhinacanthus nasutus extracts prevent glutamate and amyloid-β neurotoxicity in HT-22 mouse hippocampal cells: possible active compounds include lupeol, stigmasterol and β-sitosterol. International journal of molecular sciences, 2012, Volume: 13, Issue:4 Topics: Acanthaceae; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Cell Line; Glutamic Acid; Glutathione; Hippocampus; Mice; Neuroprotective Agents; Neurotoxicity Syndromes; Oxidative Stress; Pentacyclic Triterpenes; Plant Extracts; Plant Leaves; Plant Roots; Reactive Oxygen Species; Sitosterols; Stigmasterol	2012
Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β. Nature, 2012, May-02, Volume: 485, Issue:7400 Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Disease Models, Animal; Glutamic Acid; Humans; Mice; Mice, Transgenic; Mutant Proteins; Peptide Fragments; Prions; tau Proteins	2012
Pooling/bootstrap-based GWAS (pbGWAS) identifies new loci modifying the age of onset in PSEN1 p.Glu280Ala Alzheimer's disease. Molecular psychiatry, 2013, Volume: 18, Issue:5 Topics: Age of Onset; Alanine; Alzheimer Disease; Cohort Studies; Databases, Factual; Female; Founder Effect; Gene Frequency; Genetic Predisposition to Disease; Genome-Wide Association Study; Genotype; Glutamic Acid; Humans; Male; Mutation; Polymorphism, Single Nucleotide; Presenilin-1; Quantitative Trait Loci	2013
Na+ and K+ ion imbalances in Alzheimer's disease. Biochimica et biophysica acta, 2012, Volume: 1822, Issue:11 Topics: Alzheimer Disease; Amino Acid Transport System X-AG; Amyloid beta-Peptides; Animals; Astrocytes; Brain; Excitatory Amino Acid Transporter 2; Glutamic Acid; HEK293 Cells; Humans; Jurkat Cells; Mice; Potassium; Sodium; Sodium-Potassium-Exchanging ATPase	2012
Age-related changes in brain metabolites and cognitive function in APP/PS1 transgenic mice. Behavioural brain research, 2012, Nov-01, Volume: 235, Issue:1 Topics: Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Biomarkers; Choline; Creatine; Disease Models, Animal; Functional Neuroimaging; Glutamic Acid; Hippocampus; Inositol; Magnetic Resonance Spectroscopy; Maze Learning; Mice; Mice, Transgenic; Presenilin-1; Protons	2012
Altered neurochemical profile in the McGill-R-Thy1-APP rat model of Alzheimer's disease: a longitudinal in vivo 1 H MRS study. Journal of neurochemistry, 2012, Volume: 123, Issue:4 Topics: Age Factors; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Choline; Creatine; Disease Models, Animal; Female; Frontal Lobe; gamma-Aminobutyric Acid; Genotype; Glutamic Acid; Inositol; Longitudinal Studies; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Protons; Rats; Rats, Transgenic	2012
Parkin prevents cortical atrophy and Aβ-induced alterations of brain metabolism: ¹³C NMR and magnetic resonance imaging studies in AD models. Neuroscience, 2012, Dec-06, Volume: 225 Topics: Adaptor Proteins, Signal Transducing; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Atrophy; Brain; Carbon Isotopes; Carrier Proteins; Cell Cycle Proteins; Disease Models, Animal; DNA-Binding Proteins; Enzyme-Linked Immunosorbent Assay; Eukaryotic Initiation Factors; Gene Knock-In Techniques; Genetic Vectors; Glial Fibrillary Acidic Protein; Glutamic Acid; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Mice; Mice, Transgenic; Peptide Fragments; Phosphoproteins; Presenilin-1; Single-Blind Method; tau Proteins; TOR Serine-Threonine Kinases; Transcription Factors; Ubiquitin-Protein Ligases	2012
Restoration of dopamine release deficits during object recognition memory acquisition attenuates cognitive impairment in a triple transgenic mice model of Alzheimer's disease. Learning & memory (Cold Spring Harbor, N.Y.), 2012, Sep-14, Volume: 19, Issue:10 Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Cognition Disorders; Disease Models, Animal; Dopamine; Dopamine Uptake Inhibitors; Exploratory Behavior; Glutamic Acid; Humans; Male; Memory Disorders; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microdialysis; Mutation; Nomifensine; Norepinephrine; Photic Stimulation; Presenilin-1; Recognition, Psychology; Statistics, Nonparametric; tau Proteins	2012
Bambusae Caulis in Taeniam modulates neuroprotective and anti-neuroinflammatory effects in hippocampal and microglial cells via HO-1- and Nrf-2-mediated pathways. International journal of molecular medicine, 2012, Volume: 30, Issue:6 Topics: Alzheimer Disease; Animals; Anti-Inflammatory Agents; Bambusa; Cell Line; Cell Survival; Cytokines; Drugs, Chinese Herbal; Enzyme Induction; Glutamic Acid; Heme Oxygenase-1; Hippocampus; Inflammation Mediators; Lipopolysaccharides; Membrane Proteins; Mice; Microglia; Neurons; Neuroprotective Agents; NF-E2-Related Factor 2; Nitrites; Protein Transport; Reactive Oxygen Species; Transcriptional Activation	2012
MICEST: a potential tool for non-invasive detection of molecular changes in Alzheimer's disease. Journal of neuroscience methods, 2013, Jan-15, Volume: 212, Issue:1 Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Biomarkers; Brain Mapping; Choline; Creatine; Disease Models, Animal; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Glutamic Acid; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Transgenic; Neuroimaging; Presenilin-1; Tritium	2013
Imaging of glutamate neurotransmitter alterations in Alzheimer's disease. NMR in biomedicine, 2013, Volume: 26, Issue:4 Topics: Alzheimer Disease; Animals; Brain; Glutamic Acid; Humans; Magnetic Resonance Spectroscopy; Mice, Transgenic; Neurotransmitter Agents; Reproducibility of Results	2013
Longitudinal monitoring of sex-related in vivo metabolic changes in the brain of Alzheimer's disease transgenic mouse using magnetic resonance spectroscopy. Journal of Alzheimer's disease : JAD, 2013, Volume: 34, Issue:4 Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Aspartic Acid; Brain; Creatine; Disease Models, Animal; Female; Glutamic Acid; Humans; Iron; Linear Models; Longitudinal Studies; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Presenilin-1	2013
Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part I: creatine kinase BB, glutamine synthase, and ubiquitin carboxy-terminal hydrolase L-1. Free radical biology & medicine, 2002, Aug-15, Volume: 33, Issue:4 Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Antibodies, Monoclonal; Blotting, Western; Brain Chemistry; Creatine Kinase; Creatine Kinase, BB Form; Electrophoresis, Gel, Two-Dimensional; Free Radicals; Glutamate-Ammonia Ligase; Glutamic Acid; Glutamine; Humans; Image Processing, Computer-Assisted; Isoenzymes; Nerve Degeneration; Nerve Tissue Proteins; Oxidation-Reduction; Proteomics; Rosaniline Dyes; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Staining and Labeling; Thiolester Hydrolases; Ubiquitin Thiolesterase	2002
Protective effect of dopamine D2 agonists in cortical neurons via the phosphatidylinositol 3 kinase cascade. Journal of neuroscience research, 2002, Nov-01, Volume: 70, Issue:3 Topics: Alzheimer Disease; Animals; Bromocriptine; Cell Survival; Cells, Cultured; Cerebral Cortex; Dopamine Agonists; Dopamine D2 Receptor Antagonists; Enzyme Inhibitors; Fetus; Glutamic Acid; Ionophores; Neurons; Neuroprotective Agents; Nitric Oxide Donors; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Quinpirole; Rats; Receptors, Dopamine D2; Up-Regulation	2002
Novel cognitive improving and neuroprotective activities of Polygala tenuifolia Willdenow extract, BT-11. Journal of neuroscience research, 2002, Nov-01, Volume: 70, Issue:3 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cell Survival; Cells, Cultured; Cholinesterase Inhibitors; Cognition; Cognition Disorders; Disease Models, Animal; Excitatory Amino Acid Antagonists; Female; Fetus; Glutamic Acid; Male; Memory; Memory Disorders; Neuroprotective Agents; Phytotherapy; Plant Extracts; Polygala; Rats; Rats, Sprague-Dawley	2002
Alterations of chaperone protein expression in presenilin mutant neurons in response to glutamate excitotoxicity. Pathology international, 2002, Volume: 52, Issue:9 Topics: Alzheimer Disease; Animals; Blotting, Northern; Cells, Cultured; Chaperonins; Gene Expression Profiling; Gene Library; Glutamic Acid; Membrane Proteins; Mice; Mice, Knockout; Mice, Neurologic Mutants; Nerve Tissue Proteins; Neurons; Nuclear Proteins; Nucleophosmin; Presenilin-1	2002
Excitatory amino acid transporter EAAT-2 in tangle-bearing neurons in Alzheimer's disease. Brain pathology (Zurich, Switzerland), 2002, Volume: 12, Issue:4 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain; Excitatory Amino Acid Transporter 2; Female; Glutamic Acid; Humans; Immunohistochemistry; Male; Middle Aged; Neurofibrillary Tangles; Neurons; Synaptic Transmission; tau Proteins	2002
Fleeting activation of ionotropic glutamate receptors sensitizes cortical neurons to complement attack. Neuron, 2002, Oct-24, Volume: 36, Issue:3 Topics: Alzheimer Disease; Animals; Astrocytes; Calcium Signaling; Cell Membrane; Cells, Cultured; Cerebral Cortex; Coculture Techniques; Complement Membrane Attack Complex; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Fetus; Glutamic Acid; L-Lactate Dehydrogenase; Neurons; Neurotoxins; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptors, Glutamate	2002
Neuroprotection by memantine against neurodegeneration induced by beta-amyloid(1-40). Brain research, 2002, Dec-20, Volume: 958, Issue:1 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Astrocytes; Cell Death; Dentate Gyrus; Ectodysplasins; Excitatory Amino Acid Antagonists; Female; Glial Fibrillary Acidic Protein; Glutamic Acid; Hippocampus; Immunohistochemistry; Memantine; Membrane Proteins; Microglia; Microtubule-Associated Proteins; Motor Activity; Neurons; Peptide Fragments; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate	2002
Human glioma cells and undifferentiated primary astrocytes that express aberrant EAAT2 mRNA inhibit normal EAAT2 protein expression and prevent cell death. Molecular and cellular neurosciences, 2002, Volume: 21, Issue:4 Topics: 5' Untranslated Regions; Alternative Splicing; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Apoptosis; Astrocytes; Clone Cells; Excitatory Amino Acid Transporter 2; Exons; Gene Expression Regulation; Glioma; Glutamic Acid; Humans; Neurotransmitter Uptake Inhibitors; RNA, Messenger; Synaptic Transmission; Tumor Cells, Cultured	2002
Amyloid beta protein enhances the clearance of extracellular L-glutamate by cultured rat cortical astrocytes. Neuroscience research, 2003, Volume: 45, Issue:1 Topics: Alzheimer Disease; Amino Acid Transport System X-AG; Amyloid beta-Peptides; Animals; Animals, Newborn; Antioxidants; Astrocytes; Blotting, Western; Cells, Cultured; Cerebral Cortex; Extracellular Space; Glutamic Acid; Rats; Rats, Wistar; Time Factors	2003
Long-term potentiation is increased in the CA1 area of the hippocampus of APP(swe/ind) CRND8 mice. Neurobiology of disease, 2002, Volume: 11, Issue:3 Topics: Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Disease Models, Animal; Electrophysiology; Excitatory Postsynaptic Potentials; Fluorescent Antibody Technique; gamma-Aminobutyric Acid; Genotype; Glutamic Acid; Hippocampus; Long-Term Potentiation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Neural Inhibition; Neuronal Plasticity; Plaque, Amyloid; Synaptic Transmission	2002
Presenilin-1 mutation sensitizes oligodendrocytes to glutamate and amyloid toxicities, and exacerbates white matter damage and memory impairment in mice. Neuromolecular medicine, 2003, Volume: 3, Issue:1 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Newborn; Brain; Calcium Signaling; Cell Death; Cells, Cultured; Disease Models, Animal; Glutamic Acid; Male; Membrane Proteins; Memory Disorders; Mice; Mice, Mutant Strains; Mutation; Myelin Sheath; Nerve Fibers, Myelinated; Oligodendroglia; Peptide Fragments; Presenilin-1	2003
Quantitation of alternatively spliced NMDA receptor NR1 isoform mRNA transcripts in human brain by competitive RT-PCR. Brain research. Brain research protocols, 2003, Volume: 11, Issue:1 Topics: Alternative Splicing; Alzheimer Disease; Brain; Brain Chemistry; Cloning, Molecular; Gene Expression Regulation; Glutamic Acid; Humans; Neurons; Protein Isoforms; Protein Subunits; Receptors, N-Methyl-D-Aspartate; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Synapses; Synaptic Transmission; Templates, Genetic	2003
Motor cortex hyperexcitability to transcranial magnetic stimulation in Alzheimer's disease: evidence of impaired glutamatergic neurotransmission? Annals of neurology, 2003, Volume: 53, Issue:6 Topics: Alzheimer Disease; Glutamic Acid; Humans; Motor Cortex; Receptors, N-Methyl-D-Aspartate; Skull; Synaptic Transmission; Transcranial Magnetic Stimulation	2003
Interleukin-6, beta-amyloid peptide and NMDA interactions in rat cortical neurons. Journal of neuroimmunology, 2003, Volume: 139, Issue:1-2 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Calcium Signaling; Cell Death; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Drug Interactions; Encephalitis; Excitatory Amino Acid Agonists; Fetus; Glutamic Acid; Interleukin-6; N-Methylaspartate; Nerve Degeneration; Neurons; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate	2003
Alzheimer's amyloid beta-peptide enhances ATP/gap junction-mediated calcium-wave propagation in astrocytes. Neuromolecular medicine, 2003, Volume: 3, Issue:3 Topics: Adenosine Triphosphate; Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Newborn; Astrocytes; Calcium Channels; Calcium Signaling; Cell Communication; Cell Membrane; Cerebral Cortex; Extracellular Space; Gap Junctions; Glutamic Acid; Membrane Potentials; Octanols; Peptide Fragments; Rats; Rats, Sprague-Dawley; Suramin; Up-Regulation	2003
Brain metabolism in Alzheimer disease and vascular dementia assessed by in vivo proton magnetic resonance spectroscopy. Psychiatry research, 2003, Jul-30, Volume: 123, Issue:3 Topics: Aged; Alzheimer Disease; Atrophy; Brain; Dementia, Vascular; Energy Metabolism; Female; Glutamic Acid; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Nerve Net; Neuroglia; Neurons; Protons	2003
Synaptic vesicle transport and synaptic membrane transporter sites in excitatory amino acid nerve terminals in Alzheimer disease. Journal of neural transmission (Vienna, Austria : 1996), 2003, Volume: 110, Issue:9 Topics: Aged; Alzheimer Disease; Aspartic Acid; Binding Sites; Biological Transport; Cerebral Cortex; Down-Regulation; Excitatory Amino Acids; Female; Glutamic Acid; Humans; Male; Middle Aged; Presynaptic Terminals; Radioligand Assay; Synaptic Membranes; Synaptic Vesicles; Tritium	2003
Structure-based rational design of chemical ligands for AMPA-subtype glutamate receptors. Journal of molecular neuroscience : MN, 2003, Volume: 20, Issue:3 Topics: Alzheimer Disease; Binding Sites; Brain; Drug Design; Drug Evaluation, Preclinical; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Ligands; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Molecular Structure; Radioisotopes; Receptors, AMPA; Synaptic Transmission	2003
Structural involvement of the glutamatergic presynaptic boutons in a transgenic mouse model expressing early onset amyloid pathology. Neuroscience letters, 2003, Dec-19, Volume: 353, Issue:2 Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Cerebral Cortex; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamic Acid; Image Processing, Computer-Assisted; Immunohistochemistry; Mice; Mice, Transgenic; Neurites; Neuropil; Plaque, Amyloid; Presynaptic Terminals	2003
Glutamate transporters in platelets: EAAT1 decrease in aging and in Alzheimer's disease. Neurobiology of aging, 2004, Volume: 25, Issue:2 Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amino Acid Transport System X-AG; Blood Platelets; Blotting, Western; Brain; Case-Control Studies; Cell Line; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Excitatory Amino Acid Transporter 3; Female; Gene Expression; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Humans; Immunohistochemistry; Microscopy, Immunoelectron; Middle Aged; Monocytes; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Symporters	2004
Presenilin-1 deficiency impairs glutamate-evoked intracellular calcium responses in neurons. Neuroscience, 2004, Volume: 124, Issue:3 Topics: Alzheimer Disease; Animals; beta-Galactosidase; Brain; Calcium; Calcium Signaling; Cells, Cultured; Disease Models, Animal; Endoplasmic Reticulum; Fetus; Genes, Reporter; Genetic Vectors; Glutamic Acid; Intracellular Fluid; Membrane Proteins; Mice; Mice, Knockout; Neurons; Presenilin-1; Synaptic Transmission	2004
The E318G substitution in PSEN1 gene is not connected with Alzheimer's disease in a large Polish cohort. Neuroscience letters, 2004, Mar-11, Volume: 357, Issue:3 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Case-Control Studies; Chi-Square Distribution; Cohort Studies; DNA Mutational Analysis; Female; Gene Frequency; Glutamic Acid; Glycine; Humans; Male; Membrane Proteins; Middle Aged; Parkinson Disease; Point Mutation; Poland; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Presenilin-1	2004
Taurine prevents the neurotoxicity of beta-amyloid and glutamate receptor agonists: activation of GABA receptors and possible implications for Alzheimer's disease and other neurological disorders. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2004, Volume: 18, Issue:3 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Cells, Cultured; Cellular Senescence; Chick Embryo; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Eye Proteins; Glutamic Acid; Kainic Acid; N-Methylaspartate; Neurons; Neuroprotective Agents; Picrotoxin; Receptors, AMPA; Receptors, GABA; Receptors, GABA-A; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Retina; Taurine	2004
Memantine inhibits and reverses the Alzheimer type abnormal hyperphosphorylation of tau and associated neurodegeneration. FEBS letters, 2004, May-21, Volume: 566, Issue:1-3 Topics: 2-Amino-5-phosphonovalerate; Alzheimer Disease; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Kynurenic Acid; Memantine; Microtubule-Associated Proteins; Nerve Degeneration; Neurofibrils; Neuroprotective Agents; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Rats; Rats, Wistar; tau Proteins	2004
Incubation of nerve endings with a physiological concentration of Abeta1-42 activates CaV2.2(N-Type)-voltage operated calcium channels and acutely increases glutamate and noradrenaline release. Journal of Alzheimer's disease : JAD, 2004, Volume: 6, Issue:3 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cerebral Cortex; Female; Glutamic Acid; Hippocampus; Male; Nerve Degeneration; Nerve Endings; Nerve Tissue Proteins; Norepinephrine; Peptide Fragments; Plaque, Amyloid; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Rats, Wistar; Reactive Oxygen Species	2004
Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004, Jun-30, Volume: 24, Issue:26 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Animals; Apoptosis; bcl-2-Associated X Protein; Cells, Cultured; Dizocilpine Maleate; Gene Expression Regulation; Glutamic Acid; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Immunoenzyme Techniques; Intercellular Signaling Peptides and Proteins; Nerve Degeneration; Nerve Tissue Proteins; Neurofibrillary Tangles; Neurons; Oligodeoxyribonucleotides; Peptide Fragments; Phosphorylation; Protein Processing, Post-Translational; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Quinoxalines; Rats; RNA, Messenger; Signal Transduction; tau Proteins; Tumor Suppressor Protein p53; Wnt Proteins	2004
Impact of the selective estrogen receptor modulator, tamoxifen, on neuronal outgrowth and survival following toxic insults associated with aging and Alzheimer's disease. Experimental neurology, 2004, Volume: 188, Issue:2 Topics: Aging; Alzheimer Disease; Animals; Cell Differentiation; Cell Division; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Estradiol; Estrogens; Excitatory Amino Acids; Glutamic Acid; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Selective Estrogen Receptor Modulators; Tamoxifen	2004
Oxidative stress impairs glutamate uptake in fibroblasts from patients with Alzheimer's disease. Free radical biology & medicine, 2004, Sep-15, Volume: 37, Issue:6 Topics: Acetylcysteine; Adenosine Triphosphate; Aged; Aged, 80 and over; Aldehydes; Alzheimer Disease; Animals; Antioxidants; Case-Control Studies; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Fibroblasts; Free Radicals; Glutamic Acid; Glutathione; Humans; L-Lactate Dehydrogenase; Lipid Peroxidation; Middle Aged; Oxidative Stress; Reactive Oxygen Species; Tetrazolium Salts; Thiazoles; Time Factors	2004
Cell cultures from animal models of Alzheimer's disease as a tool for faster screening and testing of drug efficacy. Journal of molecular neuroscience : MN, 2004, Volume: 24, Issue:1 Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Cell Culture Techniques; Cells, Cultured; Disease Models, Animal; Drug Evaluation, Preclinical; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; Humans; Membrane Proteins; Mice; Mice, Transgenic; Neuronal Plasticity; Neuroprotective Agents; Presenilin-1; Presynaptic Terminals; Synapsins; Time Factors; Treatment Outcome; Up-Regulation	2004
Structure-based functional design of chemical ligands for AMPA-subtype glutamate receptors. Journal of molecular neuroscience : MN, 2004, Volume: 24, Issue:1 Topics: Alzheimer Disease; Animals; Binding Sites; Binding, Competitive; Brain; Drug Design; Drug Synergism; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Ion Channels; Kainic Acid; Ligands; Magnetic Resonance Spectroscopy; Molecular Conformation; Neuroprotective Agents; Protein Structure, Tertiary; Receptors, AMPA	2004
Synaptic transmission and synchronous activity is disrupted in hippocampal slices taken from aged TAS10 mice. Hippocampus, 2005, Volume: 15, Issue:1 Topics: 4-Aminopyridine; Action Potentials; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Cortical Synchronization; Disease Models, Animal; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Long-Term Potentiation; Mice; Mice, Transgenic; Mutation; Nerve Net; Neural Inhibition; Neural Pathways; Organ Culture Techniques; Potassium Channel Blockers; Presynaptic Terminals; Quinoxalines; Synaptic Transmission	2005
Altered metabolic profile in the frontal cortex of PS2APP transgenic mice, monitored throughout their life span. Neurobiology of disease, 2005, Volume: 18, Issue:1 Topics: Age Factors; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Biomarkers; Disease Models, Animal; Disease Progression; Energy Metabolism; Female; Frontal Lobe; Glutamic Acid; Magnetic Resonance Imaging; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Plaque, Amyloid; Presenilin-2; Spectrum Analysis	2005
Solution structure of humanin, a peptide against Alzheimer's disease-related neurotoxicity. Biochemical and biophysical research communications, 2005, Apr-01, Volume: 329, Issue:1 Topics: Alzheimer Disease; Circular Dichroism; Glutamic Acid; Glycine; Humans; Intracellular Signaling Peptides and Proteins; Leucine; Magnetic Resonance Spectroscopy; Models, Molecular; Peptides; Protein Conformation; Protein Structure, Secondary; Proteins; Temperature; Trifluoroethanol; Water	2005
Interaction between interleukin-6 and intercellular adhesion molecule-1 genes and Alzheimer's disease risk. Journal of neurology, 2005, Volume: 252, Issue:4 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Chi-Square Distribution; Confidence Intervals; Female; Genotype; Glutamic Acid; Humans; Intercellular Adhesion Molecule-1; Interleukin-6; Lysine; Male; Meta-Analysis as Topic; Middle Aged; Odds Ratio; Polymorphism, Genetic; Risk	2005
Impaired metabotropic glutamate receptor/phospholipase C signaling pathway in the cerebral cortex in Alzheimer's disease and dementia with Lewy bodies correlates with stage of Alzheimer's-disease-related changes. Neurobiology of disease, 2005, Volume: 20, Issue:3 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Binding, Competitive; Disease Progression; Down-Regulation; Enzyme Activation; Female; Frontal Lobe; Glutamic Acid; Guanosine Triphosphate; Humans; Isoenzymes; Lewy Body Disease; Male; Middle Aged; Neurons; Phospholipase C beta; Radioligand Assay; Receptors, Metabotropic Glutamate; Signal Transduction; Type C Phospholipases	2005
Lecozotan (SRA-333): a selective serotonin 1A receptor antagonist that enhances the stimulated release of glutamate and acetylcholine in the hippocampus and possesses cognitive-enhancing properties. The Journal of pharmacology and experimental therapeutics, 2005, Volume: 314, Issue:3 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acetylcholine; Alzheimer Disease; Animals; Callithrix; Cognition; Columbidae; Dioxanes; Discrimination Learning; Female; Ganglia, Spinal; Glutamic Acid; Hippocampus; Macaca mulatta; Male; Methoxydimethyltryptamines; Microdialysis; Piperazines; Rats; Rats, Sprague-Dawley; Saimiri; Serotonin 5-HT1 Receptor Antagonists; Serotonin Antagonists	2005
Proton magnetic resonance spectroscopy and magnetoencephalographic estimation of delta dipole density: a combination of techniques that may contribute to the diagnosis of Alzheimer's disease. Dementia and geriatric cognitive disorders, 2005, Volume: 20, Issue:2-3 Topics: Acetylglucosamine; Aged; Alzheimer Disease; Brain Chemistry; Choline; Creatine; Female; Glutamic Acid; Humans; Inositol; Magnetic Resonance Imaging; Magnetoencephalography; Male; Middle Aged; Phosphocreatine; Regression Analysis	2005
Amino acids and transaminases activity in ventricular CSF and in brain of normal and Alzheimer patients. Neuroscience letters, 2005, Nov-04, Volume: 388, Issue:1 Topics: Aged; Aged, 80 and over; Alanine Transaminase; Alzheimer Disease; Amino Acids; Aspartate Aminotransferases; Aspartic Acid; Brain; Brain Chemistry; Cerebrospinal Fluid; Female; Glutamic Acid; Glutamine; Humans; Lateral Ventricles; Male; Middle Aged; Reference Values; Transaminases; Up-Regulation	2005
Alertness drug arouses fears about 'lifestyle' misuse. Nature, 2005, Aug-25, Volume: 436, Issue:7054 Topics: Alzheimer Disease; Animals; Attention; Benzhydryl Compounds; Clinical Trials as Topic; Cognition; Glutamic Acid; Haplorhini; Humans; Life Style; Memory; Modafinil; Narcolepsy; Sleep Deprivation	2005
Defective tumor necrosis factor-alpha-dependent control of astrocyte glutamate release in a transgenic mouse model of Alzheimer disease. The Journal of biological chemistry, 2005, Dec-23, Volume: 280, Issue:51 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Astrocytes; Base Sequence; Disease Models, Animal; DNA Primers; Gliosis; Glutamic Acid; Hippocampus; Immunohistochemistry; Mice; Mice, Transgenic; Signal Transduction; Tumor Necrosis Factor-alpha	2005
The amyloid pathology progresses in a neurotransmitter-specific manner. Neurobiology of aging, 2006, Volume: 27, Issue:11 Topics: Acetylcholine; Aged; Aged, 80 and over; Alzheimer Disease; Animals; Blotting, Western; Brain; Female; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Male; Mice; Mice, Transgenic; Neurites; Presynaptic Terminals; Rats	2006
NMDA receptor subunit-dependent modulation by conantokin-G and Ala7-conantokin-G. Journal of neurochemistry, 2006, Volume: 96, Issue:1 Topics: Alanine; Alzheimer Disease; Animals; Concanavalin A; Conotoxins; Electrophysiology; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Membrane Potentials; Oocytes; Patch-Clamp Techniques; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Xenopus	2006
Glutamate metabolizing enzymes in prefrontal cortex of Alzheimer's disease patients. Neurochemical research, 2005, Volume: 30, Issue:11 Topics: Aged; Alzheimer Disease; Amide Synthases; Female; Glutamate Dehydrogenase; Glutamate-Ammonia Ligase; Glutamic Acid; Glutaminase; Humans; Isoenzymes; Male; Middle Aged; Nerve Tissue Proteins; Prefrontal Cortex; Statistics as Topic; Tissue Extracts	2005
C-terminal truncation modulates both nucleation and extension phases of tau fibrillization. FEBS letters, 2006, Jan-09, Volume: 580, Issue:1 Topics: Alzheimer Disease; Aspartic Acid; Caspases; Glutamic Acid; Humans; Membrane Proteins; Multiprotein Complexes; Protein Processing, Post-Translational	2006
[Also consider non-cognitive disorders]. Krankenpflege Journal, 2005, Volume: 43, Issue:7-10 Topics: Aged; Alzheimer Disease; Brain; Cognition Disorders; Depressive Disorder; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Memantine; Mental Disorders; Treatment Outcome	2005
Select estrogens within the complex formulation of conjugated equine estrogens (Premarin) are protective against neurodegenerative insults: implications for a composition of estrogen therapy to promote neuronal function and prevent Alzheimer's disease. BMC neuroscience, 2006, Mar-13, Volume: 7 Topics: Adenosine Triphosphate; Alzheimer Disease; Amyloid beta-Peptides; Animals; Basal Nucleus of Meynert; Brain; Cell Survival; Cells, Cultured; Computer Simulation; Dose-Response Relationship, Drug; Estrogens; Estrogens, Conjugated (USP); Female; Glutamic Acid; Humans; L-Lactate Dehydrogenase; Male; Molecular Structure; Neurons; Neuroprotective Agents; Neurotoxins; Peptide Fragments; Rats; Rats, Sprague-Dawley; Receptors, Estrogen	2006
System Xc- and apolipoprotein E expressed by microglia have opposite effects on the neurotoxicity of amyloid-beta peptide 1-40. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006, Mar-22, Volume: 26, Issue:12 Topics: Alzheimer Disease; Amino Acid Transport System y+; Amyloid beta-Peptides; Animals; Apolipoproteins E; Cell Communication; Cell Death; Cell Survival; Cells, Cultured; Coculture Techniques; Female; Gene Expression Regulation; Glutamic Acid; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Microglia; Nerve Degeneration; Neurons; Peptide Fragments; Rats; Rats, Wistar	2006
Studies on the amount of aluminum and calcium in urine following aluminum administration with and without amino acids. Physiological chemistry and physics and medical NMR, 2005, Volume: 37, Issue:1 Topics: Aluminum; Alzheimer Disease; Amino Acids; Animals; Calcium; Glutamic Acid; Glycine; Mice; Neurotoxins	2005
Acetylcholinesterase inhibitors used in treatment of Alzheimer's disease prevent glutamate neurotoxicity via nicotinic acetylcholine receptors and phosphatidylinositol 3-kinase cascade. Neuropharmacology, 2006, Volume: 51, Issue:3 Topics: Alzheimer Disease; Animals; Apoptosis; Blotting, Western; Cell Count; Cells, Cultured; Cerebral Cortex; Cholinergic Antagonists; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; Enzyme Inhibitors; Glutamic Acid; Neurons; Neurotoxicity Syndromes; Phosphatidylinositol 3-Kinases; Rats; Rats, Wistar; Receptors, Nicotinic; Time Factors	2006
Memantine: the next trend in academic performance enhancement? The Journal of the American Osteopathic Association, 2006, Volume: 106, Issue:6 Topics: Alzheimer Disease; Cognition; Dopamine Agents; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Memantine; Memory; Neurons; Receptors, N-Methyl-D-Aspartate	2006
Regulation of NAA-synthesis in the human brain in vivo: Canavan's disease, Alzheimer's disease and schizophrenia. Advances in experimental medicine and biology, 2006, Volume: 576 Topics: Alzheimer Disease; Aspartic Acid; Brain; Canavan Disease; Child; Glutamic Acid; Humans; Magnetic Resonance Imaging; Molecular Structure; Schizophrenia	2006
Disrupted muscarinic M1 receptor signaling correlates with loss of protein kinase C activity and glutamatergic deficit in Alzheimer's disease. Neurobiology of aging, 2007, Volume: 28, Issue:9 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain; Brain Chemistry; Case-Control Studies; Dizocilpine Maleate; Drug Interactions; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Humans; Male; Muscarinic Antagonists; Pirenzepine; Postmortem Changes; Protein Kinase C; Radioligand Assay; Receptor, Muscarinic M1; src-Family Kinases	2007
Presenilin-1 mutation E318G and familial Alzheimer's disease in the Italian population. Neurobiology of aging, 2007, Volume: 28, Issue:11 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amino Acid Substitution; Case-Control Studies; Female; Genetic Carrier Screening; Glutamic Acid; Glycine; Humans; Italy; Male; Middle Aged; Mutation; Pedigree; Presenilin-1	2007
Protective effects of ginsenoside Rg2 against glutamate-induced neurotoxicity in PC12 cells. Journal of ethnopharmacology, 2007, May-22, Volume: 111, Issue:3 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Apoptosis; Calcium; Calcium Channel Blockers; Calpain; Caspase 3; Cell Survival; Dose-Response Relationship, Drug; Gene Expression; Ginsenosides; Glutamic Acid; Lipid Peroxidation; Neuroprotective Agents; Neurotoxicity Syndromes; Nimodipine; Oxidative Stress; Panax; PC12 Cells; Peptide Fragments; Rats	2007
Properties of glutamate receptors of Alzheimer's disease brain transplanted to frog oocytes. Proceedings of the National Academy of Sciences of the United States of America, 2007, Feb-20, Volume: 104, Issue:8 Topics: Alzheimer Disease; Animals; Anura; Benzothiadiazines; Blotting, Western; Brain Tissue Transplantation; Cell Membrane; Cerebral Cortex; Electric Conductivity; gamma-Aminobutyric Acid; Gene Expression Regulation; Glutamic Acid; Humans; Kainic Acid; Oocytes; Protein Subunits; Receptors, GABA; Receptors, Glutamate; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors	2007
Beta-amyloid causes downregulation of calcineurin in neurons through induction of oxidative stress. Neurobiology of disease, 2007, Volume: 26, Issue:2 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Calcineurin; Cell Line; Cricetinae; Down-Regulation; Female; Glutamic Acid; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microscopy, Immunoelectron; Mossy Fibers, Hippocampal; Neurons; Oxidative Stress; Plaque, Amyloid; Presynaptic Terminals; Superoxide Dismutase; Superoxide Dismutase-1	2007
Alterations in expression of glutamatergic transporters and receptors in sporadic Alzheimer's disease. Journal of Alzheimer's disease : JAD, 2007, Volume: 11, Issue:1 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain; Female; Gene Expression Regulation; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Humans; Male; Middle Aged; Oligonucleotide Array Sequence Analysis; Plaque, Amyloid; Receptors, Glutamate; Reference Values; Reverse Transcriptase Polymerase Chain Reaction	2007
Amyloid beta-peptide Abeta(1-42) but not Abeta(1-40) attenuates synaptic AMPA receptor function. Synapse (New York, N.Y.), 2007, Volume: 61, Issue:6 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; Ion Channel Gating; Organ Culture Techniques; Patch-Clamp Techniques; Peptide Fragments; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Synapses; Synaptic Transmission; Synaptosomes	2007
Alterations in NMDA receptor subunit densities and ligand binding to glycine recognition sites are associated with chronic anxiety in Alzheimer's disease. Neurobiology of aging, 2008, Volume: 29, Issue:10 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Anxiety Disorders; Binding, Competitive; Brain; Chronic Disease; Female; Glutamic Acid; Glycine; Humans; Ligands; Male; Neocortex; Neurons; Neuropsychological Tests; Protein Binding; Protein Subunits; Radioligand Assay; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate	2008
3,4-dihydroxybenzoic acid from Smilacis chinae rhizome protects amyloid beta protein (25-35)-induced neurotoxicity in cultured rat cortical neurons. Neuroscience letters, 2007, Jun-13, Volume: 420, Issue:2 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Calcium; Calcium Signaling; Caspase 3; Caspase Inhibitors; Cell Survival; Cells, Cultured; Cerebral Cortex; Cytoprotection; Glutamic Acid; Hydroxybenzoates; Indicators and Reagents; Maianthemum; Nerve Degeneration; Neurons; Neuroprotective Agents; Peptide Fragments; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species	2007
N-terminal cleavage of GSK-3 by calpain: a new form of GSK-3 regulation. The Journal of biological chemistry, 2007, Aug-03, Volume: 282, Issue:31 Topics: Alzheimer Disease; Animals; Brain; Calpain; Dose-Response Relationship, Drug; Gene Expression Regulation; Glutamic Acid; Glycogen Synthase Kinase 3; Inhibitory Concentration 50; Isoenzymes; Mice; Models, Biological; Protein Structure, Tertiary; Recombinant Proteins; Signal Transduction	2007
Inhibition of Pin1 reduces glutamate-induced perikaryal accumulation of phosphorylated neurofilament-H in neurons. Molecular biology of the cell, 2007, Volume: 18, Issue:9 Topics: Alzheimer Disease; Amyotrophic Lateral Sclerosis; Animals; Apoptosis; Cell Nucleus; Ganglia, Spinal; Genes, Dominant; Glutamic Acid; Humans; Models, Biological; Naphthoquinones; Neurofilament Proteins; Neurons; NIMA-Interacting Peptidylprolyl Isomerase; Peptidylprolyl Isomerase; Phosphorylation; Protein Binding; Protein Structure, Quaternary; Protein Transport; Rats; RNA, Small Interfering; Spinal Cord; Transfection	2007
Effects of wild-type and mutant human amyloid precursor protein on cortical afferent network. Neuroreport, 2007, Aug-06, Volume: 18, Issue:12 Topics: Acetylcholine; Afferent Pathways; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Basal Nucleus of Meynert; Biomarkers; Biotin; Cerebral Cortex; Cholinergic Fibers; Dextrans; Disease Models, Animal; Enzymes; Excitatory Postsynaptic Potentials; Glutamic Acid; Humans; Inhibitory Postsynaptic Potentials; Mice; Mice, Transgenic; Mutation; Nerve Net; Norepinephrine; Presynaptic Terminals; Pyramidal Cells; Synaptic Transmission	2007
Paradoxical upregulation of glutamatergic presynaptic boutons during mild cognitive impairment. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007, Oct-03, Volume: 27, Issue:40 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Analysis of Variance; Cognition Disorders; Cohort Studies; Disease Progression; Female; Glutamic Acid; Humans; Image Processing, Computer-Assisted; Male; Neurons; Neuropsychological Tests; Plaque, Amyloid; Prefrontal Cortex; Presynaptic Terminals; Severity of Illness Index; Up-Regulation	2007
Age-related decrease in stimulated glutamate release and vesicular glutamate transporters in APP/PS1 transgenic and wild-type mice. Journal of neurochemistry, 2008, Volume: 105, Issue:3 Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Astrocytes; Brain; Disease Models, Animal; Down-Regulation; Glial Fibrillary Acidic Protein; Gliosis; Glutamic Acid; Humans; Male; Memory Disorders; Mice; Mice, Inbred C57BL; Mice, Transgenic; Plaque, Amyloid; Presenilin-1; Synaptic Transmission; Vesicular Glutamate Transport Protein 1	2008
Association between Alzheimer's disease and the NOS3 gene Glu298Asp polymorphism in Chinese. Journal of molecular neuroscience : MN, 2008, Volume: 34, Issue:2 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Apolipoprotein E4; Asian People; Aspartic Acid; Female; Genetic Predisposition to Disease; Genotype; Glutamic Acid; Humans; Nitric Oxide Synthase Type III; Polymorphism, Genetic	2008
Impaired muscarinic regulation of excitatory synaptic transmission in the APPswe/PS1dE9 mouse model of Alzheimer's disease. European journal of pharmacology, 2008, Mar-31, Volume: 583, Issue:1 Topics: Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Blotting, Western; Cholinesterase Inhibitors; Disease Models, Animal; Electric Stimulation; Electrophysiology; Excitatory Postsynaptic Potentials; Glutamic Acid; In Vitro Techniques; Mice; Mice, Transgenic; Muscarinic Antagonists; Nicotinic Antagonists; Patch-Clamp Techniques; Physostigmine; Presenilin-1; Receptors, Muscarinic; Receptors, Nicotinic; Synaptic Transmission	2008
Memantine decreases hippocampal glutamate levels: a magnetic resonance spectroscopy study. Progress in neuro-psychopharmacology & biological psychiatry, 2008, May-15, Volume: 32, Issue:4 Topics: Adult; Aged; Aging; Alzheimer Disease; Cognition Disorders; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Hippocampus; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Memantine	2008
Lovastatin induces neuroprotection through tumor necrosis factor receptor 2 signaling pathways. Journal of Alzheimer's disease : JAD, 2008, Volume: 13, Issue:2 Topics: Aged; Alzheimer Disease; Animals; Anticholesteremic Agents; Disease Models, Animal; Glutamic Acid; Humans; Lovastatin; Mice; Mice, Inbred C57BL; Neurons; Neuroprotective Agents; NF-kappa B; Phosphorylation; Proto-Oncogene Proteins c-akt; Receptors, Tumor Necrosis Factor, Type II; Signal Transduction; Stroke; Tumor Necrosis Factor-alpha	2008
Role of the familial Dutch mutation E22Q in the folding and aggregation of the 15-28 fragment of the Alzheimer amyloid-beta protein. Proceedings of the National Academy of Sciences of the United States of America, 2008, Apr-22, Volume: 105, Issue:16 Topics: Alzheimer Disease; Amino Acid Motifs; Amino Acid Sequence; Amino Acid Substitution; Amyloid beta-Peptides; Entropy; Glutamic Acid; Glutamine; Humans; Molecular Sequence Data; Mutation, Missense; Netherlands; Peptide Fragments; Protein Conformation; Protein Folding; White People	2008
Accumulation of aspartic acid421- and glutamic acid391-cleaved tau in neurofibrillary tangles correlates with progression in Alzheimer disease. Journal of neuropathology and experimental neurology, 2008, Volume: 67, Issue:5 Topics: Aged; Alzheimer Disease; Amino Acid Sequence; Apolipoprotein E4; Aspartic Acid; Brain; Disease Progression; Female; Genotype; Glutamic Acid; Humans; Immunohistochemistry; Male; Molecular Weight; Neurofibrillary Tangles; Peptide Hydrolases; Predictive Value of Tests; Protein Structure, Tertiary; Proteomics; Severity of Illness Index; tau Proteins	2008
Amino acid release from biopsy samples of temporal neocortex from patients with Alzheimer's disease. Brain research, 1983, Mar-28, Volume: 264, Issue:1 Topics: Acetylcholine; Alzheimer Disease; Amino Acids; Aspartic Acid; Dementia; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Humans; Potassium; Temporal Lobe	1983
Intralaminar neurochemical distributions in human midtemporal cortex: comparison between Alzheimer's disease and the normal. Journal of neurochemistry, 1984, Volume: 42, Issue:5 Topics: Acetylcholinesterase; Alzheimer Disease; Aspartic Acid; Butyrylcholinesterase; Cerebral Cortex; Choline O-Acetyltransferase; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Histocytochemistry; Humans; L-Lactate Dehydrogenase; Reference Values	1984
A preliminary study of free amino acids in the postmortem temporal cortex from Alzheimer-type dementia patients. Neurobiology of aging, 1984,Winter, Volume: 5, Issue:4 Topics: Aged; Alzheimer Disease; Amino Acids; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Humans; Kinetics; Middle Aged; Synaptic Transmission; Taurine; Temporal Lobe	1984
beta-Amyloid peptide fragment 25-35 potentiates the calcium-dependent release of excitatory amino acids from depolarized hippocampal slices. Journal of neuroscience research, 1995, Jul-01, Volume: 41, Issue:4 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Aspartic Acid; Calcium; Excitatory Amino Acids; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Male; Rats; Rats, Wistar	1995
17-beta estradiol protects neurons from oxidative stress-induced cell death in vitro. Biochemical and biophysical research communications, 1995, Nov-13, Volume: 216, Issue:2 Topics: Aldosterone; Alzheimer Disease; Amyloid beta-Peptides; Analysis of Variance; Animals; Antioxidants; beta-Galactosidase; Cell Death; Cell Line; Cell Survival; Cholesterol; Corticosterone; Estradiol; Glutamic Acid; Hippocampus; Humans; Hydrogen Peroxide; Luciferases; Mice; Neurons; Neurotoxins; Oxidative Stress; Progesterone; Receptors, Estrogen; Recombinant Fusion Proteins; Transfection; Vitamin E	1995
Cholinomimetics increase glutamate outflow via an action on the corticostriatal pathway: implications for Alzheimer's disease. Journal of neurochemistry, 1995, Volume: 65, Issue:5 Topics: Alzheimer Disease; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Cholinergic Agents; Corpus Striatum; Glutamic Acid; Male; Neural Pathways; Neurons; Oximes; Physostigmine; Rats; Rats, Sprague-Dawley	1995
Role of glutamate and glutamate receptors in memory function and Alzheimer's disease. Annals of the New York Academy of Sciences, 1995, May-10, Volume: 757 Topics: Adult; Aged; Alzheimer Disease; Animals; Cognition; Cycloserine; Discrimination Learning; Entorhinal Cortex; Female; Glutamic Acid; Humans; Male; Memory; N-Methylaspartate; Rats; Receptors, Glutamate; Temporal Lobe	1995
Role of cyclic GMP in the regulation of neuronal calcium and survival by secreted forms of beta-amyloid precursor. Journal of neurochemistry, 1995, Volume: 64, Issue:5 Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Calcium; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic GMP; Glutamic Acid; Hippocampus; Neurons; Rats	1995
Variant forms of neuronal glutamate transporter sites in Alzheimer's disease cerebral cortex. Journal of neurochemistry, 1995, Volume: 64, Issue:5 Topics: Aged; Alzheimer Disease; Amino Acid Transport System X-AG; Aspartic Acid; ATP-Binding Cassette Transporters; Binding Sites; Cerebral Cortex; Cysteic Acid; Female; Glutamates; Glutamic Acid; Humans; Male; Middle Aged; Neurons; Synaptic Membranes; Tissue Distribution; Tritium	1995
An in vitro 1H nuclear magnetic resonance study of the temporoparietal cortex of Alzheimer brains. Experimental brain research, 1995, Volume: 102, Issue:3 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Creatinine; Female; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neurofibrillary Tangles; Parietal Lobe; Temporal Lobe; Tomography, Emission-Computed, Single-Photon	1995
Time-related cortical amino acid changes after basal forebrain lesion: a microdialysis study. Journal of neurochemistry, 1995, Volume: 64, Issue:1 Topics: Alzheimer Disease; Amino Acids; Animals; Brain Diseases; Cerebral Cortex; Chromatography, High Pressure Liquid; Fluorescence; Glutamic Acid; Glycine; Ibotenic Acid; Male; Microdialysis; Potassium; Rats; Rats, Sprague-Dawley; Serine; Taurine; Time Factors	1995
AF64A-induced brain damage and its relation to dementia. Journal of neural transmission. Supplementum, 1994, Volume: 44 Topics: Acetylcholine; Alzheimer Disease; Animals; Aziridines; Brain Damage, Chronic; Choline; Choline O-Acetyltransferase; Corticosterone; Feedback; Female; Glucocorticoids; Glutamic Acid; Hippocampus; Humans; Male; Neuromuscular Blocking Agents; Neurotoxins; Neurotransmitter Agents; Norepinephrine; Rats; Rats, Sprague-Dawley; Serotonin; Sex Characteristics; Somatostatin; Synaptic Vesicles	1994
Effects of the mutations Glu22 to Gln and Ala21 to Gly on the aggregation of a synthetic fragment of the Alzheimer's amyloid beta/A4 peptide. Neuroscience letters, 1993, Oct-14, Volume: 161, Issue:1 Topics: Alanine; Alzheimer Disease; Amino Acid Sequence; Amyloid; Amyloid beta-Peptides; Glutamates; Glutamic Acid; Glycine; Humans; Molecular Sequence Data; Mutation	1993
Neuroprotective activity of acetyl-L-carnitine: studies in vitro. Journal of neuroscience research, 1994, Volume: 37, Issue:1 Topics: Acetylcarnitine; Alzheimer Disease; Amyloid beta-Peptides; Animals; Blood Physiological Phenomena; Cattle; Cell Death; Cells, Cultured; Cerebral Cortex; Culture Media; Energy Metabolism; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Hippocampus; Humans; Kainic Acid; N-Methylaspartate; Neurons; Peptide Fragments; Rats	1994
Selective increase of NMDA-sensitive glutamate binding in the striatum of Parkinson's disease, Alzheimer's disease, and mixed Parkinson's disease/Alzheimer's disease patients: an autoradiographic study. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1994, Volume: 14, Issue:11 Pt 1 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amino Acids; Autoradiography; Binding Sites; Carrier Proteins; Corpus Striatum; Dopamine Plasma Membrane Transport Proteins; Female; Glutamic Acid; Humans; Male; Membrane Glycoproteins; Membrane Transport Proteins; Middle Aged; N-Methylaspartate; Nerve Tissue Proteins; Parkinson Disease; Receptors, Amino Acid; Receptors, AMPA; Receptors, Glutamate	1994
Plasma concentrations of glutamate and its metabolites in patients with Alzheimer's disease. The Journal of the American Osteopathic Association, 1993, Volume: 93, Issue:6 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aminobutyrates; Aspartic Acid; Discriminant Analysis; Female; Glutamate Dehydrogenase; Glutamate-Ammonia Ligase; Glutamates; Glutamic Acid; Glutaminase; Humans; Ketoglutaric Acids; Male; Mass Screening; Middle Aged; Pilot Projects; Sensitivity and Specificity	1993
beta-Amyloid peptide-derived, oxygen-dependent free radicals inhibit glutamate uptake in cultured astrocytes: implications for Alzheimer's disease. Neuroreport, 1995, Oct-02, Volume: 6, Issue:14 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Astrocytes; Cells, Cultured; Circular Dichroism; Free Radicals; Glutamic Acid; Neurotransmitter Uptake Inhibitors; Rats; Rats, Sprague-Dawley	1995
Nicotinic and muscarinic receptor-evoked depolarizations recorded from a novel cortical brain slice preparation. Neuropharmacology, 1995, Volume: 34, Issue:10 Topics: Alzheimer Disease; Animals; Carbachol; Cerebral Cortex; Dimethylphenylpiperazinium Iodide; Dose-Response Relationship, Drug; Glutamic Acid; Male; Muscarine; Rats; Rats, Wistar; Receptors, Muscarinic; Receptors, Nicotinic	1995
Neurodegeneration mediated by glutamate and beta-amyloid peptide: a comparison and possible interaction. Brain research, 1995, Sep-11, Volume: 691, Issue:1-2 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Astrocytes; Cell Death; Cells, Cultured; Cerebral Cortex; Culture Media; Glutamic Acid; Hippocampus; L-Lactate Dehydrogenase; Nerve Degeneration; Neuropeptides; Peptide Fragments; Rats; Rats, Wistar	1995
Enhanced pathologic properties of Dutch-type mutant amyloid beta-protein. Proceedings of the National Academy of Sciences of the United States of America, 1996, Apr-02, Volume: 93, Issue:7 Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloidosis; Cell Survival; Cells, Cultured; Cerebral Hemorrhage; Glutamic Acid; Glutamine; Humans; Kinetics; Meninges; Muscle, Smooth, Vascular; Netherlands; Peptide Fragments; Point Mutation	1996
Interleukin-1beta and glutamate activate the NF-kappaB/Rel binding site from the regulatory region of the amyloid precursor protein gene in primary neuronal cultures. The Journal of biological chemistry, 1996, Jun-21, Volume: 271, Issue:25 Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Base Sequence; Binding Sites; Cell Line; Cell Nucleus; Cells, Cultured; Cerebellum; Gene Expression Regulation; Glutamic Acid; Humans; Interleukin-1; Kinetics; Molecular Sequence Data; Neuroblastoma; Neurons; NF-kappa B; Oligodeoxyribonucleotides; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-rel; Rats; Rats, Sprague-Dawley; Regulatory Sequences, Nucleic Acid; Transcription Factors; Transcriptional Activation; Transfection	1996
Increased activity-regulating and neuroprotective efficacy of alpha-secretase-derived secreted amyloid precursor protein conferred by a C-terminal heparin-binding domain. Journal of neurochemistry, 1996, Volume: 67, Issue:5 Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Base Sequence; Binding Sites; Calcium; Cell Line; Cell Survival; Cells, Cultured; Cloning, Molecular; Endopeptidases; Escherichia coli; Fetus; Glutamic Acid; Glutathione Transferase; Heparin; Heparin Lyase; Hippocampus; Humans; Kidney; Molecular Sequence Data; Mutagenesis, Site-Directed; Neurons; Patch-Clamp Techniques; Peptide Fragments; Polymerase Chain Reaction; Polysaccharide-Lyases; Potassium Channels; Rats; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Recombinant Fusion Proteins	1996
A novel mutation of presenilin 1 in familial Alzheimer's disease in Israel detected by denaturing gradient gel electrophoresis. Human genetics, 1996, Volume: 98, Issue:6 Topics: Alzheimer Disease; Aspartic Acid; Electrophoresis, Polyacrylamide Gel; Exons; Female; Glutamic Acid; Humans; Male; Membrane Proteins; Middle Aged; Pedigree; Presenilin-1; Seizures	1996
Normal glutamate metabolism in Alzheimer's disease fibroblasts deficient in alpha-ketoglutarate dehydrogenase complex activity. Developmental neuroscience, 1996, Volume: 18, Issue:5-6 Topics: Alzheimer Disease; Decarboxylation; Female; Fibroblasts; Glutamic Acid; Humans; Ketoglutarate Dehydrogenase Complex; Ketoglutaric Acids; Male; Middle Aged; Nitrogen Radioisotopes; Reference Values	1996
Glucocorticoids enhance oxidative stress-induced cell death in hippocampal neurons in vitro. Endocrinology, 1997, Volume: 138, Issue:1 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cell Death; Cells, Cultured; Glucocorticoids; Glutamic Acid; Hippocampus; Mice; Oxidative Stress; Rats; Receptors, Glucocorticoid	1997
Clinical features of early-onset Alzheimer disease in a large kindred with an E280A presenilin-1 mutation. JAMA, 1997, Mar-12, Volume: 277, Issue:10 Topics: Adult; Age of Onset; Alanine; Alzheimer Disease; Autopsy; Brain; Codon; Female; Glutamic Acid; Headache; Humans; Male; Membrane Proteins; Middle Aged; Neuropsychological Tests; Pedigree; Phenotype; Point Mutation; Presenilin-1	1997
Frontotemporal dementia and early Alzheimer disease: differentiation with frontal lobe H-1 MR spectroscopy. Radiology, 1997, Volume: 203, Issue:3 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Dementia; Discriminant Analysis; Female; Frontal Lobe; Glutamic Acid; Glutamine; Humans; Hydrogen; Inositol; Lactates; Linear Models; Magnetic Resonance Spectroscopy; Male; Middle Aged; Nerve Degeneration; Neuroglia; Neurons; Parietal Lobe; Protons; Sensitivity and Specificity; Temporal Lobe	1997
Possible association of missense mutation (Gly[-63]Glu) of the neurotrophin-3 gene with Alzheimer's disease in Japanese. Neuroscience letters, 1998, Jan-23, Volume: 241, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Alleles; Alzheimer Disease; Amino Acid Substitution; Female; Genetic Markers; Genotype; Glutamic Acid; Glycine; Humans; Japan; Male; Nerve Growth Factors; Neurotrophin 3; Point Mutation	1998
Do aluminium and/or glutamate induce Alzheimer PHF-like formation? An electron microscopic study. Journal of neurocytology, 1998, Volume: 27, Issue:1 Topics: Aluminum; Alzheimer Disease; Animals; Cerebral Cortex; Citric Acid; Culture Techniques; Embryo, Mammalian; Glutamic Acid; Microscopy, Electron; Neurofibrillary Tangles; Neurons; Rats; Rats, Wistar	1998
Survival of cultured neurons from amyloid precursor protein knock-out mice against Alzheimer's amyloid-beta toxicity and oxidative stress. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998, Aug-15, Volume: 18, Issue:16 Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Cell Survival; Cells, Cultured; Cerebellum; Cerebral Cortex; Fibroblast Growth Factor 2; Glutamic Acid; Hydrogen Peroxide; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Oxidative Stress; Peptide Fragments; Superoxides	1998
Altered Ca2+ signaling and mitochondrial deficiencies in hippocampal neurons of trisomy 16 mice: a model of Down's syndrome. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998, Sep-15, Volume: 18, Issue:18 Topics: Aging; Alzheimer Disease; Animals; Calcium; Carcinogens; Cell Death; Cyclosporine; Diploidy; Disease Models, Animal; Down Syndrome; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Hippocampus; Karyotyping; Male; Membrane Potentials; Mice; Mice, Neurologic Mutants; Mitochondria; NADP; Neurons; Potassium; Quinoxalines; Signal Transduction; Trisomy; Vitamin E	1998
[Regional cerebral blood flow and cerebrospinal fluid amino acid analysis in elderly dementia]. No to shinkei = Brain and nerve, 1998, Volume: 50, Issue:11 Topics: Alcoholism; Alzheimer Disease; Amino Acids; Aminobutyrates; Cerebrovascular Circulation; Chronic Disease; Dementia, Vascular; Glutamic Acid; Humans; Middle Aged; Regional Blood Flow	1998
The involvement of nitric oxide in synergistic neuronal damage induced by beta-amyloid peptide and glutamate in primary rat cortical neurons. The Chinese journal of physiology, 1998, Sep-30, Volume: 41, Issue:3 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cells, Cultured; Cerebral Cortex; Drug Synergism; Enzyme Inhibitors; Glutamic Acid; L-Lactate Dehydrogenase; Nerve Degeneration; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Peptide Fragments; Rats	1998
Interindividual differences in the levels of the glutamate transporters GLAST and GLT, but no clear correlation with Alzheimer's disease. Journal of neuroscience research, 1999, Jan-15, Volume: 55, Issue:2 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amino Acid Sequence; Amino Acid Transport System X-AG; Animals; ATP-Binding Cassette Transporters; Biological Transport; Electrophoresis, Polyacrylamide Gel; Excitatory Amino Acid Transporter 2; Female; Glutamic Acid; Gyrus Cinguli; Humans; Immunoblotting; In Vitro Techniques; Male; Molecular Sequence Data; Postmortem Changes; Rats; Receptors, Neurotransmitter; Temporal Lobe	1999
Glutamate but not interleukin-6 influences the phosphorylation of tau in primary rat hippocampal neurons. Neuroscience letters, 1999, Feb-12, Volume: 261, Issue:1-2 Topics: Alzheimer Disease; Animals; Blotting, Western; Cells, Cultured; Glutamic Acid; Hippocampus; Interleukin-6; Neurites; Neurons; Phosphorylation; Rats; tau Proteins	1999
Neurotrophic factors [activity-dependent neurotrophic factor (ADNF) and basic fibroblast growth factor (bFGF)] interrupt excitotoxic neurodegenerative cascades promoted by a PS1 mutation. Proceedings of the National Academy of Sciences of the United States of America, 1999, Mar-30, Volume: 96, Issue:7 Topics: Alzheimer Disease; Amino Acid Substitution; Amyloid beta-Peptides; Animals; Calcium; Cells, Cultured; Crosses, Genetic; Female; Free Radicals; Gene Expression Regulation; Glutamic Acid; Hippocampus; Humans; Lipid Peroxidation; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Transgenic; Mitochondria; Neurons; Neurotoxins; Point Mutation; Presenilin-1; Reactive Oxygen Species	1999
Evidence for neuroprotective effects of acidic fibroblast growth factor in Alzheimer disease. Journal of neuropathology and experimental neurology, 1999, Volume: 58, Issue:3 Topics: Alzheimer Disease; Case-Control Studies; Cell Death; Cells, Cultured; Down-Regulation; Female; Fibroblast Growth Factor 1; Glutamic Acid; Humans; Male; Neurofibrillary Tangles; Neurons; Neuroprotective Agents; Receptors, Fibroblast Growth Factor; Receptors, N-Methyl-D-Aspartate	1999
Complement-derived anaphylatoxin C5a protects against glutamate-mediated neurotoxicity. Journal of cellular biochemistry, 1999, Jun-01, Volume: 73, Issue:3 Topics: Alzheimer Disease; Animals; Blotting, Northern; Brain; Brain Diseases; Caspase 3; Caspases; Cells, Cultured; Complement C5a; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glutamic Acid; Hippocampus; Humans; Kainic Acid; Mice; Neurotoxins; Recombinant Proteins; Time Factors	1999
Interleukin-1beta activates forebrain glial cells and increases nitric oxide production and cortical glutamate and GABA release in vivo: implications for Alzheimer's disease. Neuroscience, 1999, Volume: 91, Issue:3 Topics: Acetylcholine; Alzheimer Disease; Animals; Cerebral Cortex; Extracellular Space; gamma-Aminobutyric Acid; Glutamic Acid; Immunohistochemistry; Interleukin-1; Male; Motor Activity; Neuroglia; Nitric Oxide; Prosencephalon; Rats; Rats, Wistar; Ultrasonography	1999
Secreted form of amyloid precursor protein enhances basal glucose and glutamate transport and protects against oxidative impairment of glucose and glutamate transport in synaptosomes by a cyclic GMP-mediated mechanism. Journal of neurochemistry, 1999, Volume: 73, Issue:2 Topics: 8-Bromo Cyclic Adenosine Monophosphate; Alkaloids; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Apoptosis; Biological Transport; Carbazoles; Cerebral Cortex; Cyclic GMP; Enzyme Inhibitors; Female; Ferrous Compounds; Glucose; Glutamic Acid; Indoles; Lipid Peroxidation; Neurons; Neurotoxins; Oxidative Stress; Rats; Rats, Sprague-Dawley; Synapses; Synaptosomes; Tritium	1999
Apoptotic pathways mobilized in microglia and neurones as a consequence of chromogranin A-induced microglial activation. Journal of neurochemistry, 1999, Volume: 73, Issue:2 Topics: Alzheimer Disease; Animals; Apoptosis; Biomarkers; Caspase 1; Caspase 3; Caspase Inhibitors; Caspases; Cell Size; Cells, Cultured; Cerebellum; Chromogranin A; Chromogranins; Enzyme Inhibitors; Glial Fibrillary Acidic Protein; Glutamic Acid; Macrophages; Microglia; Nerve Degeneration; Neurons; Neurotoxins; Nitric Oxide; Nitroarginine; Oligopeptides; Rats	1999
The A beta 3-pyroglutamyl and 11-pyroglutamyl peptides found in senile plaque have greater beta-sheet forming and aggregation propensities in vitro than full-length A beta. Biochemistry, 1999, Aug-17, Volume: 38, Issue:33 Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Glutamic Acid; Humans; Hydrogen-Ion Concentration; Micelles; Molecular Sequence Data; Peptide Fragments; Plaque, Amyloid; Protein Structure, Secondary; Sodium Dodecyl Sulfate; Solutions	1999
Gluthatione level is altered in lymphoblasts from patients with familial Alzheimer's disease. Neuroscience letters, 1999, Nov-12, Volume: 275, Issue:2 Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Glutamate-Cysteine Ligase; Glutamic Acid; Glutathione; Glutathione Disulfide; Humans; Lymphocyte Activation; Lymphocytes; Membrane Proteins; Oxidation-Reduction; Presenilin-1	1999
Glutamate toxicity in rat cultured neurones: effects on amyloid precursor-like protein 2. Neuroscience letters, 1999, Dec-03, Volume: 276, Issue:2 Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; L-Lactate Dehydrogenase; Nerve Tissue Proteins; Neurons; Rats; Receptors, N-Methyl-D-Aspartate	1999
Neuronal-glial interactions mediated by interleukin-1 enhance neuronal acetylcholinesterase activity and mRNA expression. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000, Jan-01, Volume: 20, Issue:1 Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Brain; Cell Communication; Choline O-Acetyltransferase; Gene Expression Regulation, Enzymologic; Glutamic Acid; Interleukin-1; Male; Microglia; Neurons; PC12 Cells; Rats; Rats, Sprague-Dawley; RNA, Messenger	2000
Effect of aluminium-induced Alzheimer like condition on oxidative energy metabolism in rat liver, brain and heart mitochondria. Mechanisms of ageing and development, 1999, Dec-07, Volume: 112, Issue:1 Topics: Adenosine Diphosphate; Adenosine Triphosphatases; Aging; Aluminum Chloride; Aluminum Compounds; Alzheimer Disease; Animals; Body Temperature; Brain; Chlorides; Disease Models, Animal; Energy Metabolism; Glutamic Acid; Male; Membrane Fluidity; Mitochondria, Heart; Mitochondria, Liver; Oxidative Phosphorylation; Rats	1999
Neurotoxicity induces cleavage of p35 to p25 by calpain. Nature, 2000, May-18, Volume: 405, Issue:6784 Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Animals; Calcium; Calpain; Cells, Cultured; Egtazic Acid; Glutamic Acid; Hydrogen Peroxide; Ionomycin; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Nerve Tissue Proteins; Neurons; Peptide Fragments; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Recombinant Proteins	2000
L-glutamate, L-arginine and L-citrulline levels in cerebrospinal fluid of Parkinson's disease, multiple system atrophy, and Alzheimer's disease patients. Journal of neural transmission (Vienna, Austria : 1996), 2000, Volume: 107, Issue:2 Topics: Aged; Alzheimer Disease; Arginine; Citrulline; Glutamic Acid; Humans; Middle Aged; Multiple System Atrophy; Neurons; Nitric Oxide; Nitric Oxide Synthase; Parkinson Disease	2000
Copper catalyzed oxidation of Alzheimer Abeta. Cellular and molecular biology (Noisy-le-Grand, France), 2000, Volume: 46, Issue:4 Topics: Alzheimer Disease; Amino Acids; Amyloid beta-Peptides; Arginine; Catalysis; Chromatography, High Pressure Liquid; Copper; Glutamic Acid; Glutamine; Histidine; Humans; Hydrogen Peroxide; Iron; Oxidation-Reduction; Oxygen; Peptide Fragments; Protein Processing, Post-Translational; Time Factors; Tyrosine	2000
beta-amyloid neurotoxicity is mediated by a glutamate-triggered excitotoxic cascade in rat nucleus basalis. The European journal of neuroscience, 2000, Volume: 12, Issue:8 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Aspartic Acid; Astrocytes; Basal Nucleus of Meynert; Calcium; Calcium Radioisotopes; Cells, Cultured; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Microdialysis; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Rats; Receptors, N-Methyl-D-Aspartate; Taurine	2000
No evidence for an association between the Glu298Asp polymorphism of the NOS3 gene and Alzheimer's disease. Journal of neural transmission (Vienna, Austria : 1996), 2000, Volume: 107, Issue:8-9 Topics: Aged; Alzheimer Disease; Aspartic Acid; Child; Female; Gene Frequency; Genotype; Glutamic Acid; Humans; Japan; Middle Aged; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Polymorphism, Single Nucleotide	2000
Acrolein, a product of lipid peroxidation, inhibits glucose and glutamate uptake in primary neuronal cultures. Free radical biology & medicine, 2000, Oct-15, Volume: 29, Issue:8 Topics: Acrolein; Alzheimer Disease; Animals; Biological Transport, Active; Cells, Cultured; Cerebral Cortex; Glucose; Glutamic Acid; Humans; Lipid Peroxidation; Nerve Degeneration; Neurons; Oxidative Stress; Rats	2000
Presenilin-1 P264L knock-in mutation: differential effects on abeta production, amyloid deposition, and neuronal vulnerability. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000, Dec-01, Volume: 20, Issue:23 Topics: Alzheimer Disease; Amino Acid Substitution; Amyloid; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Apoptosis; Calpain; Caspases; Cell Survival; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Gene Targeting; Glutamic Acid; Homozygote; Membrane Proteins; Mice; Mice, Mutant Strains; Mice, Transgenic; Neurons; Peptide Fragments; Presenilin-1; Staurosporine	2000
Differences between GABA levels in Alzheimer's disease and Down syndrome with Alzheimer-like neuropathology. Naunyn-Schmiedeberg's archives of pharmacology, 2001, Volume: 363, Issue:2 Topics: Adult; Aged; Alzheimer Disease; Amino Acids; Brain; Down Syndrome; Female; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Male; Middle Aged; Statistics, Nonparametric	2001
Hippocampal neurons of mice deficient in DNA-dependent protein kinase exhibit increased vulnerability to DNA damage, oxidative stress and excitotoxicity. Brain research. Molecular brain research, 2001, Mar-05, Volume: 87, Issue:2 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Camptothecin; DNA Damage; DNA-Activated Protein Kinase; DNA-Binding Proteins; Enzyme Inhibitors; Epilepsy; Etoposide; Glutamic Acid; Hippocampus; Mice; Mice, SCID; Neurons; Neurotoxins; Nucleic Acid Synthesis Inhibitors; Oxidative Stress; Protein Serine-Threonine Kinases; Topoisomerase I Inhibitors	2001
Decreased glutamate + glutamine in Alzheimer's disease detected in vivo with (1)H-MRS at 0.5 T. Neurology, 2001, Mar-27, Volume: 56, Issue:6 Topics: Activities of Daily Living; Aged; Aged, 80 and over; Alzheimer Disease; Brain; Female; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Protons	2001
The Glu298Asp polymorphism in the NOS3 gene is not associated with sporadic Alzheimer's disease. Journal of neurology, neurosurgery, and psychiatry, 2001, Volume: 70, Issue:4 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Glutamic Acid; Humans; Middle Aged; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Polymorphism, Genetic	2001
Nongenomic antiapoptotic signal transduction by estrogen in cultured cortical neurons. Journal of neuroscience research, 2001, Jun-01, Volume: 64, Issue:5 Topics: Alzheimer Disease; Animals; Apoptosis; Cells, Cultured; Cerebral Cortex; Cyclic AMP Response Element-Binding Protein; Enzyme Inhibitors; Estradiol; Estrogen Replacement Therapy; Fetus; Glutamic Acid; Menopause; Nerve Degeneration; Neurons; Neuroprotective Agents; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Serine; Signal Transduction; Staurosporine	2001
Neuroprotective effects of extracellular glutamate are absent in hippocampal organotypic cultures treated with the amyloid peptide Abeta(25-35). Brain research, 2001, Jul-13, Volume: 907, Issue:1-2 Topics: Alzheimer Disease; Amyloid beta-Peptides; Androstadienes; Animals; Cell Death; Culture Media, Serum-Free; Dentate Gyrus; Enzyme Inhibitors; Extracellular Space; Flavonoids; Fluorescent Dyes; Glutamic Acid; Hippocampus; MAP Kinase Signaling System; Microscopy, Confocal; Neuroprotective Agents; Organ Culture Techniques; Peptide Fragments; Phosphoinositide-3 Kinase Inhibitors; Propidium; Rats; Rats, Wistar; Receptors, Glutamate; Wortmannin	2001
Corticotropin-releasing hormone protects neurons against insults relevant to the pathogenesis of Alzheimer's disease. Neurobiology of disease, 2001, Volume: 8, Issue:3 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Apoptosis; Calcium; Cells, Cultured; Cerebral Cortex; Corticotropin-Releasing Hormone; Cyclic AMP; Gene Expression; Glucocorticoids; Glutamic Acid; Hippocampus; Homeostasis; Hypothalamo-Hypophyseal System; Lipid Peroxidation; Mice; Mice, Transgenic; Nerve Degeneration; Neurons; Neuroprotective Agents; Oxidative Stress; Pituitary-Adrenal System; Rats; Rats, Sprague-Dawley; RNA, Messenger	2001
Amyloid beta proteins inhibit Cl(-)-ATPase activity in cultured rat hippocampal neurons. Journal of neurochemistry, 2001, Volume: 78, Issue:3 Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenosine Triphosphatases; Alzheimer Disease; Amyloid beta-Peptides; Animals; Anion Transport Proteins; Cell Fractionation; Cell Survival; Cells, Cultured; Chlorides; DNA Fragmentation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glutamic Acid; Hippocampus; Humans; Inositol; Neurons; Peptide Fragments; Phosphatidylinositol Phosphates; Phosphatidylinositols; Rats; Rats, Wistar; Time Factors	2001
Effects of ENA713 and CHF2819, two anti-Alzheimer's disease drugs, on rat amino acid levels. Brain research, 2001, Aug-10, Volume: 910, Issue:1-2 Topics: Alzheimer Disease; Animals; Arginine; Aspartic Acid; Carbamates; Cholinesterase Inhibitors; Citrulline; Cyclic N-Oxides; Dose-Response Relationship, Drug; Excitatory Amino Acids; Extracellular Space; Glutamic Acid; Hippocampus; Male; Microdialysis; Neurons; Phenylcarbamates; Rats; Rats, Wistar; Rivastigmine; Synaptic Transmission; Taurine	2001
Deficiency of presenilin-1 increases calcium-dependent vulnerability of neurons to oxidative stress in vitro. Journal of neurochemistry, 2001, Volume: 78, Issue:4 Topics: Alzheimer Disease; Animals; Calcium; Cell Survival; Cells, Cultured; Cerebral Cortex; Chelating Agents; Egtazic Acid; Glutamic Acid; Hippocampus; Humans; Immunoblotting; Immunohistochemistry; Membrane Proteins; Mice; Mice, Transgenic; Neurons; Oxidative Stress; Peroxides; Presenilin-1	2001
Increased glutamate in CSF and plasma of patients with HIV dementia. Neurology, 2001, Aug-28, Volume: 57, Issue:4 Topics: Adult; AIDS Dementia Complex; Alzheimer Disease; Analysis of Variance; Atrophy; Brain; Female; Glutamic Acid; Humans; Linear Models; Male; Middle Aged; Nervous System Diseases	2001
Changes in the cellular distribution of glutamine synthetase in Alzheimer's disease. Journal of neuroscience research, 2001, Dec-01, Volume: 66, Issue:5 Topics: Aged; Alzheimer Disease; Astrocytes; Capillaries; Cell Size; Cerebral Cortex; Down-Regulation; Glial Fibrillary Acidic Protein; Glutamate-Ammonia Ligase; Glutamic Acid; Humans; Immunohistochemistry; Middle Aged; Neurites; Neurons; Plaque, Amyloid; Presynaptic Terminals	2001
Spermidine antagonizes the inhibitory effect of huperzine A on [3H]dizocilpine (MK-801) binding in synaptic membrane of rat cerebral cortex. Neuroscience letters, 2002, Feb-15, Volume: 319, Issue:2 Topics: Alkaloids; Alzheimer Disease; Animals; Binding Sites; Binding, Competitive; Cerebral Cortex; Cholinesterase Inhibitors; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Neurons; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sesquiterpenes; Spermidine; Synaptic Membranes	2002
Proton MR spectroscopic study at 3 Tesla on glutamate/glutamine in Alzheimer's disease. Neuroreport, 2002, Jan-21, Volume: 13, Issue:1 Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain; Creatine; Female; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Phosphocreatine; Reference Values; Tissue Distribution	2002
Effects of estrogen treatment on glutamate uptake in cultured human astrocytes derived from cortex of Alzheimer's disease patients. Journal of neurochemistry, 2002, Volume: 80, Issue:5 Topics: Alzheimer Disease; Amino Acid Transport System X-AG; Astrocytes; Blotting, Western; Cells, Cultured; Cerebral Cortex; Estradiol; Estrogens; Excitatory Amino Acid Transporter 2; Glutamic Acid; Humans; Immunohistochemistry	2002
Cholinergic nicotinic systems in Alzheimer's disease: prospects for pharmacological intervention. CNS drugs, 2002, Volume: 16, Issue:7 Topics: Acetylcholine; Alzheimer Disease; Animals; Cholinergic Agents; Cognition; Glutamic Acid; Humans; Neurons; Receptors, Nicotinic	2002
Spermine modulation of the glutamate(NMDA) receptor is differentially responsive to conantokins in normal and Alzheimer's disease human cerebral cortex. Journal of neurochemistry, 2002, Volume: 81, Issue:4 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amino Acid Substitution; Binding, Competitive; Cerebral Cortex; Conotoxins; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Humans; Ligands; Male; Middle Aged; Mutagenesis, Site-Directed; Radioligand Assay; Receptors, N-Methyl-D-Aspartate; Spermine	2002
Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis. The New England journal of medicine, 1992, May-28, Volume: 326, Issue:22 Topics: Aged; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Biological Transport; Brain; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Humans; Huntington Disease; In Vitro Techniques; Male; Middle Aged; Motor Cortex; Phenylalanine; Somatosensory Cortex; Spinal Cord; Synaptosomes; Visual Cortex	1992
A dose-dependent increase of Tau immunostaining is produced by glutamate toxicity in primary neuronal cultures. Brain research, 1992, Feb-14, Volume: 572, Issue:1-2 Topics: Alzheimer Disease; Animals; Cells, Cultured; Cerebral Cortex; Glutamates; Glutamic Acid; Immunohistochemistry; Nerve Degeneration; Neurons; Rats; tau Proteins	1992
N-acetyl-L-aspartate and other amino acid metabolites in Alzheimer's disease brain: a preliminary proton nuclear magnetic resonance study. Neurology, 1992, Volume: 42, Issue:8 Topics: Aged; Alzheimer Disease; Amino Acids; Aspartic Acid; Brain; Cadaver; Female; Glutamates; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Male	1992
Tau antigenic changes induced by glutamate in rat primary culture model: a biochemical approach. Neuroscience letters, 1992, Jun-22, Volume: 140, Issue:2 Topics: Alzheimer Disease; Animals; Cells, Cultured; Glutamates; Glutamic Acid; Immunoblotting; Neurons; Rats; tau Proteins	1992
Protection from dementia. Science (New York, N.Y.), 1992, Nov-27, Volume: 258, Issue:5087 Topics: Alzheimer Disease; Energy Metabolism; Glutamates; Glutamic Acid; Humans; Synaptic Transmission	1992
Framing beta-amyloid. Nature genetics, 1992, Volume: 1, Issue:4 Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Brain; Cerebrovascular Disorders; Codon; Genotype; Glutamates; Glutamic Acid; Glutamine; Humans; Molecular Sequence Data; Mutation; Phenotype; Protein Structure, Secondary	1992
Characterisation of the glycine modulatory site of the N-methyl-D-aspartate receptor-ionophore complex in human brain. Journal of neurochemistry, 1991, Volume: 56, Issue:1 Topics: Aged; Aged, 80 and over; Allosteric Site; Alzheimer Disease; Animals; Cell Membrane; Cerebral Cortex; Coma; Dizocilpine Maleate; Female; Frontal Lobe; Glutamates; Glutamic Acid; Glycine; Humans; Male; Papio; Postmortem Changes; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate	1991
Glutamate-, glutaminase-, and taurine-immunoreactive neurons develop neurofibrillary tangles in Alzheimer's disease. Annals of neurology, 1991, Volume: 29, Issue:2 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Female; Glutamates; Glutamic Acid; Glutaminase; Hippocampus; Humans; Immunologic Techniques; Male; Middle Aged; Neurofibrils; Neurons; Taurine	1991
Peptides homologous to the amyloid protein of Alzheimer's disease containing a glutamine for glutamic acid substitution have accelerated amyloid fibril formation. Biochemical and biophysical research communications, 1991, Sep-30, Volume: 179, Issue:3 Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Glutamates; Glutamic Acid; Glutamine; Microscopy, Electron; Microscopy, Immunoelectron; Molecular Sequence Data; Mutation; Myofibrils; Peptides	1991
[3H]N-[1-(2-thienyl)cyclohexyl]-3,4-piperidine ([3H]TCP) binding in human frontal cortex: decreases in Alzheimer-type dementia. Journal of neurochemistry, 1990, Volume: 54, Issue:2 Topics: Alzheimer Disease; Aspartic Acid; Binding Sites; Frontal Lobe; Glutamates; Glutamic Acid; Humans; Membranes; N-Methylaspartate; Phencyclidine; Reference Values	1990
Glutamic acid concentration in brains of patients with Alzheimer's disease. Biochemical Society transactions, 1990, Volume: 18, Issue:3 Topics: Alzheimer Disease; Amino Acids; Brain; Glutamates; Glutamic Acid; Humans	1990
Ante mortem cerebral amino acid concentrations indicate selective degeneration of glutamate-enriched neurons in Alzheimer's disease. Neuroscience, 1990, Volume: 38, Issue:3 Topics: Alzheimer Disease; Amino Acids; Brain; Glutamates; Glutamic Acid; Humans; Male; Middle Aged; Nerve Degeneration; Neurons; Osmolar Concentration; Postmortem Changes	1990
Selective reduction of quisqualate (AMPA) receptors in Alzheimer cerebellum. Annals of neurology, 1990, Volume: 28, Issue:6 Topics: Aged; Aged, 80 and over; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Alzheimer Disease; Autoradiography; Cerebellum; Female; Glutamates; Glutamic Acid; Humans; Ibotenic Acid; Kainic Acid; Kinetics; Male; N-Methylaspartate; Radioligand Assay; Receptors, AMPA; Receptors, Neurotransmitter	1990
Neurosciences advance in basic and clinical realms. Science (New York, N.Y.), 1986, Dec-12, Volume: 234, Issue:4782 Topics: Alzheimer Disease; Animals; Brain; Cells, Cultured; Glutamates; Glutamic Acid; Humans; Ion Channels; Mollusca; Neurons; Neurotransmitter Agents; Time Factors	1986
Alzheimer's disease: glutamate depletion in the hippocampal perforant pathway zone. Annals of neurology, 1987, Volume: 22, Issue:1 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Glutamates; Glutamic Acid; Hippocampus; Histocytochemistry; Humans; Middle Aged; Neurofibrils; Staining and Labeling	1987
Reduced glycine stimulation of [3H]MK-801 binding in Alzheimer's disease. Journal of neurochemistry, 1989, Volume: 53, Issue:3 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain; Cell Membrane; Cerebellar Cortex; Dibenzocycloheptenes; Dizocilpine Maleate; Female; Frontal Lobe; Glutamates; Glutamic Acid; Glycine; Humans; Male; Middle Aged; Parietal Lobe; Postmortem Changes; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Temporal Lobe; Time Factors	1989
Loss of glycine-dependent radioligand binding to the N-methyl-D-aspartate-phencyclidine receptor complex in patients with Alzheimer's disease. Neuroscience letters, 1989, Jun-05, Volume: 101, Issue:1 Topics: Alzheimer Disease; Glutamates; Glutamic Acid; Glycine; Humans; Kinetics; Radioligand Assay; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine	1989
Alterations in L-glutamate binding in Alzheimer's and Huntington's diseases. Science (New York, N.Y.), 1985, Mar-22, Volume: 227, Issue:4693 Topics: Alzheimer Disease; Autoradiography; Binding Sites; Brain; Caudate Nucleus; Cerebral Cortex; Choline O-Acetyltransferase; Glutamates; Glutamic Acid; Humans; Huntington Disease; Putamen; Receptors, Glutamate; Receptors, Neurotransmitter	1985
Putative amino acid transmitters in lumbar cerebrospinal fluid of patients with histologically verified Alzheimer's dementia. Journal of neurology, neurosurgery, and psychiatry, 1985, Volume: 48, Issue:5 Topics: Adult; Aged; Alzheimer Disease; Amino Acids; Aspartic Acid; Dementia; Epilepsy; Female; Glutamates; Glutamic Acid; Glycine; Humans; Male; Middle Aged; Neurotransmitter Agents	1985
Controlled induction of paired helical filaments of the Alzheimer type in cultured human neurons, by glutamate and aspartate. Journal of the neurological sciences, 1985, Volume: 68, Issue:2-3 Topics: Alzheimer Disease; Aspartic Acid; Culture Techniques; Cytoskeleton; Fetus; Glutamates; Glutamic Acid; Humans; Microscopy, Electron; Models, Neurological; Neurofibrils; Spinal Cord	1985
Regional distribution of amino acid transmitters in postmortem brains of presenile and senile dementia of Alzheimer type. Annals of neurology, 1986, Volume: 19, Issue:3 Topics: Aged; Aging; Alzheimer Disease; Aspartic Acid; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Humans; Male; Middle Aged; Nerve Tissue Proteins; Osmolar Concentration; Postmortem Changes; Tissue Distribution	1986
Plasticity in hippocampal excitatory amino acid receptors in Alzheimer's disease. Neuroscience research, 1986, Volume: 3, Issue:6 Topics: Aged; Alzheimer Disease; Aspartic Acid; Autoradiography; Female; Glutamates; Glutamic Acid; Hippocampus; Humans; Kainic Acid; Male; Middle Aged; N-Methylaspartate; Neuronal Plasticity; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synaptic Transmission	1986
A postmortem study of amino acid neurotransmitters in Alzheimer's disease. Annals of neurology, 1986, Volume: 20, Issue:5 Topics: Aged; Aging; Alanine; Alzheimer Disease; Amino Acids; Aspartic Acid; Brain; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Humans; Neurotransmitter Agents; Taurine	1986
Dementia of the Alzheimer's type: changes in hippocampal L-[3H]glutamate binding. Journal of neurochemistry, 1987, Volume: 48, Issue:2 Topics: Alzheimer Disease; Aspartic Acid; Autoradiography; Flunitrazepam; Glutamates; Glutamic Acid; Hippocampus; Histocytochemistry; Humans; Muscimol; N-Methylaspartate; Receptors, GABA-A; Receptors, Muscarinic; Tissue Distribution	1987
Density and distribution of NMDA receptors in the human hippocampus in Alzheimer's disease. Brain research, 1986, Dec-03, Volume: 399, Issue:1 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Autoradiography; Female; Glutamates; Glutamic Acid; Hippocampus; Humans; Male; Middle Aged; Neural Pathways; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter	1986
Glutamate deficits in Alzheimer's disease. Journal of neurology, neurosurgery, and psychiatry, 1987, Volume: 50, Issue:3 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain; Glutamates; Glutamic Acid; Humans; Middle Aged	1987
Region-specific loss of glutamate innervation in Alzheimer's disease. Neuroscience letters, 1987, Jan-02, Volume: 73, Issue:1 Topics: Alzheimer Disease; Aspartic Acid; Brain; Cerebral Cortex; Glutamates; Glutamic Acid; Hippocampus; Humans; Synaptosomes	1987
The dementia of Alzheimer's disease: an update. Journal of neurology, neurosurgery, and psychiatry, 1987, Volume: 50, Issue:2 Topics: Afferent Pathways; Alzheimer Disease; Amygdala; Animals; Aspartic Acid; Glutamates; Glutamic Acid; Male; Rats; Rats, Inbred Strains; Substantia Innominata	1987
Colchicine lesions in the rat hippocampus mimic the alterations of several markers in Alzheimer's disease. Brain research, 1987, Apr-07, Volume: 408, Issue:1-2 Topics: Alzheimer Disease; Animals; Choline O-Acetyltransferase; Colchicine; Glutamates; Glutamic Acid; Hippocampus; Learning; Male; Nerve Tissue Proteins; Rats; Rats, Inbred F344; Receptors, Glutamate; Receptors, Neurotransmitter; Synaptosomes	1987
Glutamatergic denervation in Alzheimer's disease--a cautionary note. Journal of neurology, neurosurgery, and psychiatry, 1987, Volume: 50, Issue:6 Topics: Alzheimer Disease; Aspartic Acid; Brain; Glutamates; Glutamic Acid; Humans; Nerve Degeneration	1987
Presynaptic and postsynaptic glutamatergic function in Alzheimer's disease. Neuroscience letters, 1988, Mar-21, Volume: 86, Issue:1 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Female; Glutamates; Glutamic Acid; Humans; Male; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Temporal Lobe	1988
Regional distribution of pre- and postsynaptic glutamatergic function in Alzheimer's disease. Brain research, 1988, Jun-14, Volume: 452, Issue:1-2 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain; Caudate Nucleus; Cerebral Cortex; Female; Glutamates; Glutamic Acid; Hippocampus; Humans; Kinetics; Male; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter	1988
[Is Alzheimer's senile dementia associated with the phenomena of reactive synaptogenesis in the hippocampus?]. Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie, 1988, Volume: 306, Issue:19 Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Autoradiography; Glutamates; Glutamic Acid; Hippocampus; Humans; Kainic Acid; Middle Aged; Neuronal Plasticity; Receptors, Neurotransmitter	1988
Is senile dementia of the Alzheimer type associated with hippocampal plasticity? Brain research, 1988, Aug-09, Volume: 457, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Binding Sites; Female; Glutamates; Glutamic Acid; Hippocampus; Humans; Kainic Acid; Middle Aged; Neuronal Plasticity	1988