glucuronyl-glucosamine-glycan-sulfate and Vertigo

Comparative analysis of the groups of patients with idiopathic bilateral vestibular hypofunction and a group of vestibulopathy patients with vertebrobasilar insufficiency demonstrated identity of the basic and additional diagnostic parameters in these syndromes as well as similarity in clinical diagnostic and anamnesis data. In all cases, functional assessment of endothelium-dependent vasodilation and selected biochemical marker sICAM-1 revealed endothelial dysfunction. Drug correction of endothelial dysfunction positively affected the manifestations of major and minor features of the syndrome, which confirmed the contribution of endothelial functional disturbances to the pathogenesis of bilateral vestibular hypofunction.

Topics: Adult; Aged; Aged, 80 and over; Audiometry; Bilateral Vestibulopathy; Biomarkers; Caloric Tests; Endothelium, Vascular; Female; Glycosaminoglycans; Humans; Hypoglycemic Agents; Intercellular Adhesion Molecule-1; Male; Middle Aged; Ultrasonography, Interventional; Vasodilation; Vertebrobasilar Insufficiency; Vertigo

Topics: Adult; Aged; Drug Evaluation; Female; Glycosaminoglycans; Hearing Loss, Sensorineural; Humans; Hyperlipidemias; Hyperlipoproteinemias; Labyrinth Diseases; Male; Middle Aged; Tinnitus; Vertigo