glucuronyl-glucosamine-glycan-sulfate and Pre-Eclampsia

glucuronyl-glucosamine-glycan-sulfate has been researched along with Pre-Eclampsia* in 3 studies

Other Studies

3 other study(ies) available for glucuronyl-glucosamine-glycan-sulfate and Pre-Eclampsia

ArticleYear
[The effect of sulodexide on placental mitochondria function in rats with experimental preeclampsia].
    Biomeditsinskaia khimiia, 2016, Volume: 62, Issue:5

    Substitution of drinking water for 1.8% NaCl in pregnant rats caused a pronounced increase in arterial pressure by 24,3% and urinary protein by 117% to day 21 of pregnancy. State 4 respiration of isolated placental mitochondria in the group of negative control was 3- and 1.5-fold higher with malate/glutamate and succinate as substrates than in placental mitochondria isolated from uncomplicated pregnant animals. This led to a decrease of the respiratory control ratio. These results suggest that development of experimental preeclampsia is accompanied by mitochondrial dysfunction through uncoupling of oxidative phosphorylation. Daily administration of sulodexide to females with experimental preeclampsia (EP) per os at a dose of 30 LE during the whole period of gestation decreased manifestations of the disease as evidenced by a slight increase in blood pressure (by 8,6%) and less pronounces increase in urinary protein (by 58,9%). Sulodexide decreased development of mitochondrial dysfunction in EP rats as shown a decrease of non-stimulated ADP respiration with malate/glutamate and succinate (4.5- and 2.5-fold, respectively) as compared with the negative control group and the corresponding increase in the respiratory control ratio (2.5- and 1.5-fold, respectively). Thus, sulodexide reduces uncoupling of oxidative phosphorylation and enhances the functional activity of mitochondria in EP animals, possibly due to its antioxidant and endotelioprotective effects.. U samok, poluchavshikh vo vremia beremennosti vmesto pit'evoĭ vody 1,8% r-r NaCl, obnaruzheno vyrazhennoe povyshenie k 21 dniu beremennosti arterial'nogo davleniia (AD) na 24,3% i belka v moche na 117%, v to vremia kak u zhivotnykh, kotorym davali pit'evuiu vodu, pokazateli izmenialis' v znachitel'no men'sheĭ stepeni. Skorost' dykhaniia V4 izolirovannykh mitokhondriĭ platsenty v gruppe negativnogo kontrolia vozrastala v 3 raza dlia substrata malat/glutamat i v 1,5 raza – dlia suktsinata po sravneniiu s pokazateliami zhivotnykh s neoslozhnennoĭ beremennost'iu. Éto privodilo k snizheniiu velichin dykhatel'nogo kontrolia. Poluchennye dannye ukazyvaiut, chto razvitie u samok éksperimental'noĭ preéklampsii (ÉP) soprovozhdaetsia disfunktsieĭ mitokhondriĭ, sviazannoĭ s razobshcheniem dykhaniia i okislitel'nogo fosforilirovaniia. Sulodeksid, vvodimyĭ samkam s ÉP odin raz v den' vnutrizheludochno v doze 30 LE ves' period gestatsii, sposobstvoval ogranicheniiu razvitiia patologii. Ob étom svidetel'stvuiut neznachitel'noe povyshenie AD (na 8,6%) i belka v moche (na 58,9%). Sulodeksid ogranichival razvitie mitokhondrial'noĭ disfunktsii v platsente u zhivotnykh s ÉP, o chem svidetel'stvuet snizhenie nestimulirovannogo dykhaniia po sravneniiu s pokazateliami u samok gruppy negativnogo kontrolia dlia malata/glutamata (v 4,5 raza) i suktsinata (v 2,5 raza) i uvelichenie dykhatel'nogo kontrolia v 2,5 i 1,5 raza sootvetstvenno. Takim obrazom, sulodeksid prepiatstvuet snizheniiu razobshcheniia okislitel'nogo fosforilirovaniia i sposobstvuet povysheniiu funktsional'noĭ aktivnosti mitokhondriĭ u zhivotnykh s ÉP, chto, vozmozhno, sviazano s ego antioksidantnym i éndotelioprotektornym éffektami.

    Topics: Animals; Blood Pressure; Disease Models, Animal; Female; Glycosaminoglycans; Mitochondria; Oxidative Phosphorylation; Placenta; Pre-Eclampsia; Pregnancy; Rats

2016
GABA derivatives citrocard and salifen reduce the intensity of experimental gestosis.
    Bulletin of experimental biology and medicine, 2014, Volume: 157, Issue:1

    Substitution of drinking water with 1.8 % NaCl solution in pregnant female rats from day 1 of gestation until parturitions was followed by the development of experimental gestosis. Gestosis manifested in an increase in BP by 18.2 %, protein concentration in the urine by 6.2 times, and edema severity in muscles, brain, and omentum in comparison with the initial level. The concentration of homocysteine in blood plasma of rats with complicated pregnancy 4.4-fold surpassed that in pregnant rats without gestosis, which can probably in a cause for gestosis development. GABA derivatives citrocard (50 mg/kg) and salifen (15 mg/kg), and the reference substance sulodexide (30 U/kg) reduced the severity of gestosis manifestations, which was seen from the absence of BP rise, decrease in urinary protein concentration by 1.9, 2.0, and 1.3 times and blood level of homocysteine by 1.7, 1.5, and 2.6 times, respectively, and a decrease in edema degree in comparison with female rats with experimental gestosis receiving physiological saline.

    Topics: Animals; Blood Pressure; Brain; Female; GABA Agonists; gamma-Aminobutyric Acid; Glycosaminoglycans; Homocysteine; Muscle, Skeletal; Omentum; Pre-Eclampsia; Pregnancy; Rats; Sodium Chloride

2014
Effect of GABA derivatives on the rate of thrombus formation, platelet aggregation, and plasma coagulation capacity in rats with experimental gestosis.
    Bulletin of experimental biology and medicine, 2014, Volume: 158, Issue:2

    Experimental gestosis induced by replacement of drinking water with 1.8% NaCl promoted hypercoagulation, increased the rate and degree of platelet aggregation, and reduced clotting time in pregnant females. GABA derivatives, compounds RGPU-151, RGPU-152, and phenibut normalized parameters of hemostasis and platelet aggregation and the rate of thrombus formation in the animals. The efficiency of the test substances did not significantly differ from that of the reference drug sulodexide.

    Topics: Animals; Blood Coagulation; Dipeptides; Female; gamma-Aminobutyric Acid; Glycosaminoglycans; Nicotinic Acids; Platelet Aggregation; Pre-Eclampsia; Pregnancy; Rats; Sodium Chloride; Thrombosis

2014
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