glucuronyl-glucosamine-glycan-sulfate and Hyperlipoproteinemia-Type-II

The ability of glycosaminoglycans to bind to a wide number of biologically active macromolecules has already been investigated. Recent clinical trials on the possible therapeutic benefits of glycosaminoglycans must be placed in perspective, even if they appear to be particularly encouraging, especially as regards the glycosaminoglycan effects on certain coagulation factors. A multicenter, medium-term, double-blind, crossover trial was performed by several Italian Lipid Clinics to determine whether administration of a medium molecular weight glycosaminoglycan (Sulodexide) has a significant clinical effect. Patients affected by peripheral vascular disease and/or hyperlipidemia (type IIa, IIb and IV) were submitted to a 4-week wash-out period, followed by parenteral Sulodexide (S) or placebo (P) administration for 2 weeks, another 2 week wash-out period, parenteral crossover drug or P administration for 2 weeks and, finally, oral S administration for 6 months. Sulodexide lowered plasma viscosity and plasma fibrinogen in all patients. There was also a drop in triglycerides together with a rise in apo A-I and HDL-C in type IV hyperlipoproteinemics, whereas there was no significant effect on total or LDL-plasma cholesterol in type IIa and IIb patients. Moreover, there was a percent increase in peak flow and rest flow in the lower limbs of peripheral vascular disease patients. No side effects or intolerance phenomena were detected. The results indicate that Sulodexide administration may be useful in long-term treatment of patients with peripheral vascular disease and a concomitant increase in plasma triglycerides and/or fibrinogen and/or viscosity.

Topics: Adult; Aged; Blood Viscosity; Cholesterol; Clinical Trials as Topic; Double-Blind Method; Erythrocyte Deformability; Female; Fibrinogen; Glycosaminoglycans; Humans; Hyperlipidemias; Hyperlipoproteinemia Type II; Hyperlipoproteinemia Type V; Hypertriglyceridemia; Hypolipidemic Agents; Lipoproteins; Male; Middle Aged; Multicenter Studies as Topic; Triglycerides

Topics: Aged; Arteriosclerosis; Blood Viscosity; Clinical Trials as Topic; Double-Blind Method; Female; Glycosaminoglycans; Humans; Hyperlipoproteinemia Type II; Hyperlipoproteinemia Type IV; Hypolipidemic Agents; Lipids; Male; Middle Aged; Risk

Topics: Aged; Cerebrovascular Disorders; Female; Glycosaminoglycans; Humans; Hyperlipoproteinemia Type II; Hyperlipoproteinemia Type IV; Hyperlipoproteinemias; Hypolipidemic Agents; Male; Middle Aged; Placebos; Vascular Diseases

Topics: Adult; Aged; Cholesterol; Female; Glycosaminoglycans; Humans; Hyperlipoproteinemia Type II; Hyperlipoproteinemia Type IV; Lipids; Lipoproteins, VLDL; Male; Middle Aged; Triglycerides

Topics: Adult; Aged; Arteriosclerosis; Blood Coagulation Factors; Complement System Proteins; Female; Glycosaminoglycans; Humans; Hyperlipoproteinemia Type II; Hyperlipoproteinemia Type IV; Immunoglobulins; Lipids; Male; Middle Aged; Platelet Aggregation