glucuronyl-glucosamine-glycan-sulfate and Arteriosclerosis

The effects of 3-glucosaminoglycan sulfate on lipids and the hemorheologic parameters were observed in a preliminary double-blind crossover study in 30 hyperlipidemic peripheral vascular disease (PVD) patients. Parenteral administration of the test drug was associated with a reduction in serum lipids, especially in triglyceride levels, and a lowering of fibrinogen, plasma viscosity, and whole blood viscosity levels. These effects justify the drug's use in the treatment of PVD, especially when associated with hypertriglyceridemia and hemorheologic disturbances.

Topics: Adult; Arteriosclerosis; Blood Viscosity; Double-Blind Method; Female; Fibrinogen; Glycosaminoglycans; Humans; Hyperlipidemias; Lipids; Male; Middle Aged

Topics: Arteriosclerosis; Clinical Trials as Topic; Coronary Disease; Female; Glycosaminoglycans; Humans; Hyperlipidemias; Hypolipidemic Agents; Intracranial Arteriosclerosis; Male

Topics: Aged; Arteriosclerosis; Blood Viscosity; Clinical Trials as Topic; Double-Blind Method; Female; Glycosaminoglycans; Humans; Hyperlipoproteinemia Type II; Hyperlipoproteinemia Type IV; Hypolipidemic Agents; Lipids; Male; Middle Aged; Risk

Thirty patients suffering from peripheral vascular disease (stage-II according to Fontaine) were included in a double-blind study aimed at assessing the efficacy of a high-dose glycosaminoglycan (GAG) (Sulodexide) both in terms of laboratory parameters, such as lipid metabolism and blood coagulation components, and instrumental procedures (strain-gauge plethysmography). Compared with the fifteen control patients (treated with placebo), the fifteen patients treated with Sulodexide showed a significant decrease in blood triglycerides and fibrinogen as well as a significantly increased HDL-cholesterol, and positive instrumental changes: at the end of treatment Peak and Rest Flow values--and consequently also Winsor's index--were significantly increased only in patients treated with Sulodexide.

Topics: Aged; Arteriosclerosis; Cholesterol, HDL; Clinical Trials as Topic; Double-Blind Method; Female; Femoral Artery; Fibrinogen; Glycosaminoglycans; Humans; Intermittent Claudication; Male; Random Allocation; Triglycerides; Vascular Diseases

The aim of this study was the evaluation of some hemorheological and metabolic parameters in a group of patients affected by peripheral artery disease treated with sulodexide. A double-blind with cross-over treatment was used. The results demonstrate that sulodexide reduces blood viscosity and triglyceride levels. This action may have a role in order to modify clinical symptoms and evolution of atherosclerosis.

Topics: Arteriosclerosis; Blood Viscosity; Double-Blind Method; Erythrocyte Deformability; Glycosaminoglycans; Humans; Lipids

A total of nine patients with diabetes type I and II and with claudications due to macro- and microangiopathies of the lower extremities took sulodexide (Vessel Due F) by the i.m. route for a period of 20 days and then as capsules for 90 days. In all a favourable therapeutic effect was recorded, in particular as regards delay of claudications. The authors recorded lower blood sugar values, lower levels of cholesterol, triglycerides, fibrinogen and plasma viscosity. In the authors' view sulodexide is an important advance in the treatment of diabetics with claudications.

Topics: Arteriosclerosis; Blood Viscosity; Diabetic Angiopathies; Glycosaminoglycans; Humans; Hypolipidemic Agents; Ischemia; Leg; Male; Middle Aged

Topics: Aged; Aged, 80 and over; Arteriosclerosis; Coronary Disease; Drug Evaluation; Glycosaminoglycans; Humans; Hypolipidemic Agents; Intracranial Arteriosclerosis; Male; Middle Aged

Topics: Aged; Arteriosclerosis; Female; Glycosaminoglycans; Humans; Hypolipidemic Agents; Leg; Male; Regional Blood Flow

Topics: Adult; Aged; Arteriosclerosis; Blood Coagulation Factors; Complement System Proteins; Female; Glycosaminoglycans; Humans; Hyperlipoproteinemia Type II; Hyperlipoproteinemia Type IV; Immunoglobulins; Lipids; Male; Middle Aged; Platelet Aggregation

The Authors have studied the pharmacologic effect of glucuronil-glucose-amino-glycan sulphate on experimental vasculopathy induced by etherologue serum and by dislipidemic diet. After discussion of data they conclude the 3GS is of any helpful in third phase of the process in etherologue serum induced vasculopathy. In the case of diet induced vasculopathy is clearly demonstrated the protective effect of this drug upon the endothelial structure.

Topics: Aged; Animals; Aorta; Arteriosclerosis; Diet, Atherogenic; Endothelium; Female; Glycosaminoglycans; Humans; Male; Mesenteric Arteries; Middle Aged; Rabbits; Time Factors