glucosamine has been researched along with Insulin Sensitivity in 72 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 20 (27.78) | 18.2507 |
| 2000's | 31 (43.06) | 29.6817 |
| 2010's | 18 (25.00) | 24.3611 |
| 2020's | 3 (4.17) | 2.80 |
| Authors | Studies |
|---|---|
| Cazzola, R; Cestaro, B; Della Porta, M; Gasparri, C; Lombardoni, F; Nichetti, M; Patelli, Z; Perna, S; Pistolesi, E; Rondanelli, M | 1 |
| Bai, Y; Cao, H; Che, Q; Guo, J; Li, F; Su, Z; Zhang, Z | 1 |
| Aydogdu, G; Sermikli, BP; Yilmaz, E | 1 |
| Gao, Y; Huang, S; Li, R; Li, X; Liu, X; Mi, Y; Qi, G; Wang, Y | 1 |
| Chen, H; Huang, J; Huang, K; Li, J; Wang, Y; Xue, W; Yuan, Y; Zhang, W; Zhang, Y; Zheng, L; Zhu, X | 1 |
| Chen, K; Fan, X; Gu, N; Guo, Q; He, H; Hu, H; Liu, C; Oh, Y; Wei, X; Wu, Q; Yan, Y; Yang, D; Zhou, Y | 1 |
| Ji, DF; Li, YG; Lin, TB; Lv, ZQ; Zhong, S | 1 |
| Cho, H; Han, IO; Hwang, JS; Nam, MS; Park, JW | 1 |
| Cao, YL; Gao, M; Gu, JQ; Lin, YC; Meng, X; Wang, DF; Wang, XL; Yang, HJ | 1 |
| Du, Q; Liu, X; Liu, Z; Wang, Y; Zhu, D | 1 |
| Chen, Q; Gao, XY; Kang, YM; Li, YH; Shi, CX; Shu, XD; Wang, JJ; Xiong, XQ; Zhao, MX; Zhu, GQ | 1 |
| Chang, CF; Chen, CH; Cheng, TL; Huang, TH; Kang, L; Wang, CZ; Wu, MH | 1 |
| Atzmon, G; Barzilai, N; Bauman, J; Einstein, FH; Fishman, S; Huffman, DM; Muzumdar, RH; Thompson, RF | 1 |
| Cheng, JT; Cheng, SC; Chien, CS; Tsao, CW; Wu, HT | 1 |
| Cruz, M; Durán-Reyes, G; Foyo-Niembro, E; García-Gutiérrez, MT; García-Macedo, R; Gutiérrez-Rodríguez, ME; Kumate, J; Medina-Navarro, R; Pascoe-Lira, D; Rosales-Torres, AM; Valladares-Salgado, A; Vergara-Onofre, M | 1 |
| Andreozzi, F; Beguinot, F; Di Jeso, B; Formisano, P; Gaster, M; Iadicicco, C; Longo, M; Miele, C; Raciti, GA; Teperino, R; Ulianich, L; Ungaro, P; Vind, BF | 1 |
| Gao, Y; Liu, JK; Wang, F; Zhang, L | 1 |
| Bai, B; Dong, ZJ; Gao, Y; Hu, YN; Liu, JK; Wang, F; Zhai, QW; Zhang, L; Zhu, HJ | 1 |
| Barrientos, C; Quevedo, L; Racotta, R | 1 |
| Anastassiades, TP; Dostrovsky, NR; Hudson, RW; Towheed, TE | 1 |
| Muniyappa, R | 1 |
| Chang, CH; Chang, FM; Chang, JK; Chen, CH; Cheng, JT; Cheng, YC; Kang, L; Lee, CT | 1 |
| Pru, JK | 1 |
| Weissman, P | 1 |
| Clark, S; Filippis, A; Filippis, C; Proietto, J | 1 |
| Lund, KC; McClain, DA; Parker, GJ; Taylor, RP | 1 |
| Chen, G; Elmendorf, JS; Liu, P; Thurmond, DC | 1 |
| Fischer, S; Hanefeld, M | 1 |
| Chen, MM; Han, DH; Holloszy, JO | 1 |
| Buongiorno, A; Costanzo, BV; Di Mario, U; Frittitta, L; Giaccari, A; Morviducci, L; Spampinato, D; Trischitta, V; Vigneri, R | 1 |
| Johnston, AM; Pirola, L; Van Obberghen, E | 1 |
| García-Lorda, P; Laferrère, B; Pi-Sunyer, FX; Russell, CD | 1 |
| Bosch, RR; Hermus, AR; Olthaar, AJ; Pouwels, MJ; Span, PN; Sweep, CG; Tack, CJ | 1 |
| Bailey, CJ; Turner, SL | 1 |
| Marshall, S; Okuyama, R; Yamasaki, K | 1 |
| Clark, MG; Kolka, CM; Rattigan, S; Richards, SM; Smith, ME; Wallis, MG; Zhang, L | 1 |
| Lin, SW; Stumpf, JL | 1 |
| Bronstein, JA; Crandon, SK; Hall, G; Hortin, GL; Karne, RJ; Muniyappa, R; Quon, MJ; Ver, MR | 1 |
| Blick, KE; Cornea, A; Jenkins, A; Pham, T; Scofield, RH | 1 |
| Bonadonna, RC; Buongiorno, A; Caiola, S; Giaccari, A; Leonetti, F; Morviducci, L; Sbraccia, P; Tamburrano, G; Zorretta, D | 1 |
| Barzilai, N; Chen, W; Gindi, J; Hawkins, M; Rossetti, L | 1 |
| Buse, MG; Robinson, KA; Sens, DA | 1 |
| Baron, AD; Garvey, WT; Maianu, L; Weldon, H; Zhu, JH; Zhu, JS | 1 |
| Angelov, I; Barzilai, N; Chen, W; Cohen, P; Hawkins, M; Hu, M; Rossetti, L | 1 |
| Frost, SC; Thomson, MJ; Williams, MG | 1 |
| Barzilai, N; Chen, W; Hawkins, M; Hu, M; Liu, R; Rossetti, L | 1 |
| Daniels, MC; Hämäläinen, S; McClain, D; Utriainen, T; Virkamäki, A; Yki-Järvinen, H | 1 |
| Buse, MG; Chen, H; Feagin, AC; Ing, BL; Quon, MJ; Robinson, KA | 1 |
| Higo, K; Lee, MK; Miles, PD; Olefsky, JM; Rafaat, K; Romeo, OM | 1 |
| Chi, MM; Heimberg, H; Hresko, RC; Mueckler, M | 1 |
| Hussain, MA | 1 |
| Holmäng, A; Larsson, BM; Lönroth, P; Niklasson, M; Nilsson, C | 1 |
| Virkamäki, A; Yki-Järvinen, H | 1 |
| Dolphin, PJ; Graham, SE; Russell, JC | 1 |
| Dylewicz, P; Nowak, A; Przywarska, I; Rychlewski, T; Szcześniak, L | 1 |
| Kahn, CR; Landaker, EJ; Patti, ME; Virkamäki, A; Yki-Järvinen, H | 1 |
| McCarty, MF; Russell, AI | 1 |
| Hattori, J; Kawachi, S; Nakashima, K; Okumura, S; Sasaki, A; Sugimoto, M; Takami, K; Takami, R; Takeda, N; Yasuda, K; Yoshino, K | 1 |
| Choi, WS; Heart, E; Sung, CK | 1 |
| Accili, D; Cooksey, R; Draznin, B; Friedman, J; Goalstone, M; Golovchenko, I; Kruszynska, Y; McClain, D; Miles, P; Olefsky, J; Reitman, M; Stjernholm, R; Wall, K | 1 |
| Buse, MG; Nelson, BA; Robinson, KA | 2 |
| Fehmann, HC | 1 |
| Broschat, K; Chen, X; Gulve, EA; Hope, HR; McMahon, EG; Ross, SA; Sun, S | 1 |
| Heart, E; Kang, J; Sung, CK | 1 |
| Choi, CS; Lee, FN; Youn, JH | 1 |
| Barzilai, N; Cases, JA; Gabriely, I; Ma, XH; Rossetti, L; Yang, XM | 2 |
| Bagchi, D; Echard, BW; Funk, KA; Preuss, HG; Talpur, NA | 1 |
| Heart, E; Sung, CK | 1 |
| Hart, GW; Lane, MD; Vosseller, K; Wells, L | 1 |
| Bacote, V; Marshall, S; Traxinger, RR | 1 |
5 review(s) available for glucosamine and Insulin Sensitivity
| Article | Year |
|---|---|
The effect of glucosamine on glucose metabolism in humans: a systematic review of the literature.
Topics: Glucosamine; Glucose; Humans; Insulin Resistance; Osteoarthritis | 2011 |
Reappraisal of the pharmacologic approach to treatment of type 2 diabetes mellitus.
Topics: Administration, Oral; Antihypertensive Agents; Biguanides; Diabetes Mellitus, Type 2; Glucosamine; Hormone Replacement Therapy; Humans; Hypoglycemic Agents; Hypolipidemic Agents; Insulin; Insulin Resistance; Sulfonylurea Compounds; Thiazoles | 2002 |
Modulation of insulin action.
Topics: AMP-Activated Protein Kinases; Animals; Cytokines; Fatty Acids; Gene Expression Regulation; Glucosamine; Glycosylation; Humans; Hyperglycemia; Hyperinsulinism; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Intracellular Signaling Peptides and Proteins; Models, Biological; Multienzyme Complexes; Phosphoproteins; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; Receptor, Insulin; Repressor Proteins; Signal Transduction; Suppressor of Cytokine Signaling 1 Protein; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins; Transcription Factors | 2004 |
Effect of glucosamine on glucose control.
Topics: Blood Glucose; Databases, Bibliographic; Glucosamine; Glucose; Humans; Insulin Resistance; Osteoarthritis | 2006 |
A case for glucosamine.
Topics: Animals; Diabetes Mellitus, Type 2; Glucosamine; Humans; Insulin Resistance; Signal Transduction | 1998 |
4 trial(s) available for glucosamine and Insulin Sensitivity
| Article | Year |
|---|---|
A Randomized Double-Blind Placebo-Controlled Clinical Study to Evaluate the Effect on the Weight of a Medical Device with Polyglucosamine L112 in a Group of Overweight and Obese Subjects.
Topics: Cholesterol; Glucosamine; Humans; Insulin Resistance; Obesity; Overweight; Vitamins; Weight Loss | 2023 |
Oral glucosamine for 6 weeks at standard doses does not cause or worsen insulin resistance or endothelial dysfunction in lean or obese subjects.
Topics: Administration, Oral; Adult; Ascorbic Acid; Blood Pressure; Diabetes Mellitus, Type 1; Endothelium, Vascular; Glucosamine; Heart Rate; Humans; Insulin Resistance; Obesity; Reference Values; Thinness | 2006 |
Glucosamine levels in people with ischaemic heart disease with and without type II diabetes.
Topics: Adult; C-Peptide; Cholesterol; Diabetes Mellitus, Type 2; Glucosamine; Humans; Insulin; Insulin Resistance; Male; Middle Aged; Myocardial Infarction; Statistics, Nonparametric; Triglycerides | 1998 |
[Alpha-glucosidase inhibitor for type 2 diabetic patients. Clinical study with miglitol].
Topics: 1-Deoxynojirimycin; Diabetes Mellitus, Type 2; Glucosamine; Glycoside Hydrolase Inhibitors; Humans; Hypoglycemic Agents; Imino Pyranoses; Insulin Resistance | 2000 |
63 other study(ies) available for glucosamine and Insulin Sensitivity
| Article | Year |
|---|---|
Glucosamine Improves Non-Alcoholic Fatty Liver Disease Induced by High-Fat and High-Sugar Diet through Regulating Intestinal Barrier Function, Liver Inflammation, and Lipid Metabolism.
Topics: Animals; Diet; Diet, High-Fat; Glucosamine; Hepatitis; Inflammation; Insulin Resistance; Lipid Metabolism; Lipopolysaccharides; Liver; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Sugars | 2023 |
Role of the O-GlcNAc modification on insulin resistance and endoplasmic reticulum stress in 3T3-L1 cells.
Topics: 3T3-L1 Cells; Acetylglucosamine; Adipocytes; Animals; beta-N-Acetylhexosaminidases; Drug Resistance; Endoplasmic Reticulum Stress; Glucosamine; Glycolysis; Hexosamines; Insulin Resistance; Mice; N-Acetylglucosaminyltransferases; Oximes; Phenylcarbamates; Protein Processing, Post-Translational; RNA Interference; RNA, Small Interfering; Signal Transduction; Tunicamycin; Unfolded Protein Response | 2020 |
(-)-Epigallocatechin-3-gallate Ameliorates Insulin Resistance and Mitochondrial Dysfunction in HepG2 Cells: Involvement of Bmal1.
Topics: AMP-Activated Protein Kinases; Animals; ARNTL Transcription Factors; Catechin; Cells, Cultured; Circadian Clocks; Glucosamine; Glucose; Hep G2 Cells; Hepatocytes; Humans; Insulin Resistance; Insulin-Like Growth Factor I; Membrane Potential, Mitochondrial; Mice, Inbred C57BL; Mitochondria, Liver; Oxidative Stress | 2017 |
Histone methyltransferase G9a modulates hepatic insulin signaling via regulating HMGA1.
Topics: Animals; Blood Glucose; Diet, High-Fat; Epigenesis, Genetic; Gene Expression Regulation; Glucosamine; Glycogen Synthase Kinase 3 beta; Hep G2 Cells; Histocompatibility Antigens; Histone-Lysine N-Methyltransferase; Histones; HMGA1a Protein; Humans; Insulin; Insulin Resistance; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Palmitic Acid; Phosphorylation; Proto-Oncogene Proteins c-akt; Receptor, Insulin; Receptors, Leptin; Signal Transduction | 2018 |
Glucosamine induces increased musclin gene expression through endoplasmic reticulum stress-induced unfolding protein response signaling pathways in mouse skeletal muscle cells.
Topics: Administration, Oral; Animals; Cell Line; Endoplasmic Reticulum Stress; Gene Expression Regulation; Glucosamine; Insulin Resistance; Mice; Muscle Proteins; Muscle, Skeletal; Signal Transduction; Transcription Factors; Unfolded Protein Response | 2019 |
Hypoglycemic effect of deoxynojirimycin-polysaccharide on high fat diet and streptozotocin-induced diabetic mice via regulation of hepatic glucose metabolism.
Topics: 1-Deoxynojirimycin; Animals; Blood Glucose; Blotting, Western; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Fructose-Bisphosphatase; Glucokinase; Glucosamine; Glucose-6-Phosphatase; Hypoglycemic Agents; Insulin Resistance; Liver; Male; Mice; Mice, Inbred ICR; Phosphoenolpyruvate Carboxykinase (ATP); Phosphofructokinase-1, Liver Type; Pyruvate Carboxylase; Pyruvate Decarboxylase; Random Allocation | 2015 |
Glucosamine enhances body weight gain and reduces insulin response in mice fed chow diet but mitigates obesity, insulin resistance and impaired glucose tolerance in mice high-fat diet.
Topics: 3T3-L1 Cells; Animals; Cell Line, Tumor; Diet; Diet, High-Fat; Dietary Fats; Glucosamine; Glucose Intolerance; Glucose Tolerance Test; Humans; Insulin Resistance; Male; Mice; Mice, Inbred C57BL; Obesity; Organ Size; Weight Gain | 2015 |
Suppression of phosphatase and tensin homolog protects insulin-resistant cells from apoptosis.
Topics: Animals; Apoptosis; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Glucosamine; Glucose Transporter Type 4; Hypoglycemic Agents; Insulin; Insulin Resistance; Metformin; Muscle, Skeletal; Protein Transport; PTEN Phosphohydrolase; Rats; Up-Regulation; Vanadates | 2015 |
Cichoric Acid Reverses Insulin Resistance and Suppresses Inflammatory Responses in the Glucosamine-Induced HepG2 Cells.
Topics: Anti-Inflammatory Agents; Caffeic Acids; Dietary Supplements; Glucosamine; Glucose; Glucose Transporter Type 2; Hep G2 Cells; Humans; Hypoglycemic Agents; Inflammation; Insulin Resistance; Liver; Signal Transduction; Succinates | 2015 |
β-aminoisobutyric acid attenuates hepatic endoplasmic reticulum stress and glucose/lipid metabolic disturbance in mice with type 2 diabetes.
Topics: Administration, Oral; Aminoisobutyric Acids; AMP-Activated Protein Kinases; Animals; Apoptosis; Blood Glucose; Blotting, Western; Carbohydrate Metabolism; Cholesterol; Diabetes Mellitus, Experimental; Diet, High-Fat; Endoplasmic Reticulum Stress; Glucosamine; Hep G2 Cells; Humans; Immunohistochemistry; Insulin Resistance; Lipid Metabolism; Liver; Mice; Phosphorylation; Real-Time Polymerase Chain Reaction; RNA Interference; RNA, Small Interfering; Signal Transduction; Thapsigargin; Triglycerides; Tunicamycin | 2016 |
Exercise training ameliorates glucosamine-induced insulin resistance in ovariectomized rats.
Topics: Animals; Blood Glucose; Fasting; Female; Glucosamine; Glucose Tolerance Test; Glucose Transporter Type 4; Hypertrophy; Insulin; Insulin Resistance; Islets of Langerhans; Muscle, Skeletal; Ovariectomy; Physical Conditioning, Animal; Rats; Rats, Sprague-Dawley | 2017 |
Enhanced activation of a "nutrient-sensing" pathway with age contributes to insulin resistance.
Topics: Adiponectin; Adipose Tissue; Age Factors; Aging; Angiotensinogen; Animals; Diabetes Mellitus; Gene Expression; Glucosamine; Glycosylation; Hexosamines; Insulin; Insulin Resistance; Leptin; Plasminogen Activator Inhibitor 1; Rats; Rats, Inbred Strains; Resistin; Sp1 Transcription Factor | 2008 |
Insulin resistance induced by glucosamine in fructose-fed rats.
Topics: Animals; Cell Line; Fructose; Gene Expression; Glucosamine; Glucose; Glucose Transporter Type 4; Insulin Resistance; Male; Mice; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear | 2009 |
O-GlcNAc-selective-N-acetyl-beta-D-glucosaminidase activity and mRNA expression in muscle is related to glucosamine-induced insulin resistance.
Topics: Acetylglucosaminidase; Animals; beta-N-Acetylhexosaminidases; Gene Expression Regulation, Enzymologic; Glucosamine; Insulin Resistance; Male; Muscle, Skeletal; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2010 |
Glucosamine-induced endoplasmic reticulum stress affects GLUT4 expression via activating transcription factor 6 in rat and human skeletal muscle cells.
Topics: Activating Transcription Factor 6; Analysis of Variance; Animals; Blotting, Western; Cell Line; Cells, Cultured; Chromatin Immunoprecipitation; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Glucosamine; Glucose; Glucose Transporter Type 4; Heat-Shock Proteins; Humans; Insulin; Insulin Resistance; MADS Domain Proteins; MEF2 Transcription Factors; Middle Aged; Molecular Chaperones; Muscle Fibers, Skeletal; Myogenic Regulatory Factors; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA-Binding Proteins; RNA, Messenger; RNA, Small Interfering; Transcription Factors | 2010 |
Bi-linderone, a highly modified methyl-linderone dimer from Lindera aggregata with activity toward improvement of insulin sensitivity in vitro.
Topics: Cell Line; Crystallography, X-Ray; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Glucosamine; Humans; Insulin Resistance; Lindera; Models, Molecular; Molecular Structure; Plant Roots; Spiro Compounds | 2010 |
A pair of windmill-shaped enantiomers from Lindera aggregata with activity toward improvement of insulin sensitivity.
Topics: Glucosamine; Hep G2 Cells; Humans; Insulin; Insulin Resistance; Lactones; Lindera; Plant Extracts; Plant Roots; Spiro Compounds; Stereoisomerism | 2010 |
Glucosamine attenuates increases of intraabdominal fat, serum leptin levels, and insulin resistance induced by a high-fat diet in rats.
Topics: Animals; Blood Glucose; Body Weight; Diet; Dietary Fats; Fatty Acids, Nonesterified; Glucosamine; Glucose Tolerance Test; Insulin; Insulin Resistance; Intra-Abdominal Fat; Leptin; Male; Obesity; Rats; Rats, Wistar; Weight Loss | 2010 |
Glucosamine and osteoarthritis: time to quit?
Topics: Administration, Oral; Glucosamine; Glucose; Glycosaminoglycans; Humans; Insulin Resistance; Osteoarthritis | 2011 |
Glucosamine-induced insulin resistance in ovariectomized rats is relevant to decreasing the expression of glucose transport protein subtype 4 in the skeletal muscle and in increasing the size of pancreatic islets.
Topics: Animals; Blood Glucose; Body Weight; Dietary Supplements; Female; Glucosamine; Glucose Tolerance Test; Glucose Transporter Type 4; Hyperplasia; Insulin; Insulin Resistance; Islets of Langerhans; Muscle, Skeletal; Ovariectomy; Postmenopause; Rats; Rats, Sprague-Dawley | 2012 |
The combined effects of menopause and dietary glucosamine on the development of insulin resistance.
Topics: Animals; Dietary Supplements; Female; Glucosamine; Glucose Transporter Type 4; Insulin Resistance; Islets of Langerhans; Postmenopause | 2012 |
Activation of PI 3-kinase by the hexosamine biosynthesis pathway.
Topics: Adipocytes; Animals; Enzyme Activation; Glucosamine; Glucose; Glucose Transporter Type 4; Hexosamines; Insulin Resistance; Isoenzymes; Male; Microsomes; Monosaccharide Transport Proteins; Muscle Proteins; Phosphatidylinositol 3-Kinases; Protein Kinase C; Protein Transport; Rats; Rats, Sprague-Dawley | 2002 |
Insulin resistance of glycogen synthase mediated by o-linked N-acetylglucosamine.
Topics: 3T3 Cells; Acetylglucosamine; Animals; Cells, Cultured; Enzyme Activation; Glucosamine; Glucose; Glycogen Synthase; Glycosylation; Insulin Resistance; Mice; Phosphorylation | 2003 |
Glucosamine-induced insulin resistance is coupled to O-linked glycosylation of Munc18c.
Topics: Adipocytes; Animals; Carrier Proteins; Cells, Cultured; Glucosamine; Glucose Transporter Type 4; Glycosylation; Insulin; Insulin Resistance; Membrane Proteins; Mice; Monosaccharide Transport Proteins; Munc18 Proteins; Muscle Proteins; Nerve Tissue Proteins; Protein Transport; Proteins; Qa-SNARE Proteins; Qb-SNARE Proteins; Qc-SNARE Proteins; R-SNARE Proteins; Recombinant Proteins; SNARE Proteins; Vesicular Transport Proteins | 2003 |
[Therapy decision based on the glucose triad. Drug treatment of type 2 diabetes].
Topics: 1-Deoxynojirimycin; Acarbose; Administration, Oral; Blood Glucose; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Fasting; Glucosamine; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Imino Pyranoses; Insulin; Insulin Resistance; Insulin Secretion; Metformin; Obesity; Pioglitazone; Risk Factors; Rosiglitazone; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Time Factors | 2003 |
Glucosamine and glucose induce insulin resistance by different mechanisms in rat skeletal muscle.
Topics: Adenosine Triphosphate; Animals; Culture Techniques; Dactinomycin; Diaphragm; Forelimb; Glucosamine; Glucose; Hexosamines; Insulin; Insulin Resistance; Male; Muscle, Skeletal; Rats; Rats, Wistar; Signal Transduction; Uridine Diphosphate | 2003 |
Rats that are made insulin resistant by glucosamine treatment have impaired skeletal muscle insulin receptor phosphorylation.
Topics: Animals; Blotting, Western; Enzyme-Linked Immunosorbent Assay; Glucosamine; Glucose; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Male; Muscle, Skeletal; Phosphoproteins; Phosphoric Diester Hydrolases; Phosphorylation; Pyrophosphatases; Rats; Rats, Sprague-Dawley; Receptor, Insulin | 2003 |
Effect of oral glucosamine sulfate on serum leptin levels in human subjects.
Topics: Administration, Oral; Adolescent; Adult; Blood Glucose; Dexamethasone; Dose-Response Relationship, Drug; Fasting; Glucosamine; Humans; Insulin Resistance; Leptin; Obesity | 2004 |
Hexosamines are unlikely to function as a nutrient-sensor in 3T3-L1 adipocytes: a comparison of UDP-hexosamine levels after increased glucose flux and glucosamine treatment.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Deoxyglucose; Glucosamine; Glucose; Hexosamines; Insulin; Insulin Resistance; Mice; Uridine Diphosphate Glucose; Uridine Diphosphate N-Acetylgalactosamine; Uridine Diphosphate N-Acetylglucosamine | 2004 |
Glucosamine-induced insulin resistance in L6 muscle cells.
Topics: Animals; Cells, Cultured; Deoxyglucose; Dose-Response Relationship, Drug; Glucosamine; Insulin; Insulin Resistance; Muscle Cells; Rats | 2004 |
Glucosamine induces rapid desensitization of glucose transport in isolated adipocytes by increasing GlcN-6-P levels.
Topics: Adipocytes; Animals; Biological Transport, Active; Cells, Cultured; Dose-Response Relationship, Drug; Glucosamine; Glucose; Glucose-6-Phosphate; Insulin; Insulin Resistance; Male; Metabolic Clearance Rate; Rats; Rats, Sprague-Dawley | 2005 |
Acute glucosamine-induced insulin resistance in muscle in vivo is associated with impaired capillary recruitment.
Topics: Algorithms; Animals; Capillaries; Femoral Artery; Glucosamine; Hemodynamics; Hypoglycemic Agents; Insulin; Insulin Resistance; Male; Muscle, Skeletal; Rats; Rats, Wistar; Regional Blood Flow; Xanthine Oxidase | 2005 |
Oral glucosamine in doses used to treat osteoarthritis worsens insulin resistance.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Animals; Arteries; Blood Glucose; Cholesterol; Female; Glucosamine; Homeostasis; Humans; Insulin Resistance; Lipoproteins, LDL; Male; Middle Aged; Osteoarthritis; Triglycerides | 2007 |
In vivo effects of glucosamine on insulin secretion and insulin sensitivity in the rat: possible relevance to the maladaptive responses to chronic hyperglycaemia.
Topics: Animals; Arginine; Blood Glucose; Gluconeogenesis; Glucosamine; Glucose Clamp Technique; Homeostasis; Hyperglycemia; Insulin; Insulin Resistance; Insulin Secretion; Liver; Male; Rats; Rats, Sprague-Dawley | 1995 |
In vivo glucosamine infusion induces insulin resistance in normoglycemic but not in hyperglycemic conscious rats.
Topics: Animals; Blood Glucose; Glucosamine; Glucose; Glycogen; Glycolysis; Hexokinase; Hyperglycemia; Insulin Resistance; Male; Muscles; Rats; Rats, Sprague-Dawley | 1995 |
Pre-exposure to glucosamine induces insulin resistance of glucose transport and glycogen synthesis in isolated rat skeletal muscles. Study of mechanisms in muscle and in rat-1 fibroblasts overexpressing the human insulin receptor.
Topics: Animals; Biological Transport; Fibroblasts; Glucosamine; Glucose; Glucose Transporter Type 4; Glycogen; Glycogen Synthase; In Vitro Techniques; Insulin Resistance; Male; Monosaccharide Transport Proteins; Muscle Proteins; Muscles; Rats; Rats, Wistar; Receptor, Insulin | 1993 |
Glucosamine induces insulin resistance in vivo by affecting GLUT 4 translocation in skeletal muscle. Implications for glucose toxicity.
Topics: Animals; Blood Glucose; Cell Membrane; Dose-Response Relationship, Drug; Glucosamine; Glucose; Glucose Clamp Technique; Glucose Transporter Type 4; Hyperinsulinism; Infusions, Intravenous; Insulin; Insulin Resistance; Kinetics; Male; Monosaccharide Transport Proteins; Muscle Proteins; Muscle, Skeletal; Rats; Rats, Sprague-Dawley; Time Factors | 1995 |
Increased hexosamine availability similarly impairs the action of insulin and IGF-1 on glucose disposal.
Topics: Animals; Blood Glucose; Body Weight; Glucosamine; Glucose; Glucose Clamp Technique; Glycogen; Glycogen Synthase; Hexosamines; Insulin; Insulin Resistance; Insulin-Like Growth Factor I; Kinetics; Liver; Male; Muscle, Skeletal; Rats; Rats, Sprague-Dawley; Uridine Diphosphate N-Acetylglucosamine | 1996 |
Development of insulin resistance in 3T3-L1 adipocytes.
Topics: 3T3 Cells; Adipocytes; Animals; Biological Transport; Gene Expression Regulation; Glucosamine; Glucose; Glucose Transporter Type 4; Insulin; Insulin Resistance; Mice; Monosaccharide Transport Proteins; Muscle Proteins; Protein Processing, Post-Translational; RNA, Messenger | 1997 |
Role of the glucosamine pathway in fat-induced insulin resistance.
Topics: Animals; Diabetes Mellitus, Type 2; Fatty Acids; Fructosephosphates; Glucosamine; Glucose; Glucose-6-Phosphate; Glycogen; Glycolysis; Insulin; Insulin Resistance; Male; Muscle, Skeletal; Phosphorylation; Rats; Rats, Sprague-Dawley; Uridine | 1997 |
Activation of the hexosamine pathway by glucosamine in vivo induces insulin resistance in multiple insulin sensitive tissues.
Topics: Adipose Tissue; Animals; Blood Glucose; Deoxyglucose; Glucosamine; Glucose; Glucose Clamp Technique; Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing); Glycogen; Hexosamines; Hyperinsulinism; Infusions, Intravenous; Insulin; Insulin Resistance; Male; Muscle, Skeletal; Myocardium; Rats; Rats, Wistar; Submandibular Gland | 1997 |
Effects of overexpression of glutamine:fructose-6-phosphate amidotransferase (GFAT) and glucosamine treatment on translocation of GLUT4 in rat adipose cells.
Topics: Adipocytes; Animals; Biological Transport; Cells, Cultured; Gene Expression; Glucosamine; Glucose Transporter Type 4; Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing); Hexosamines; Humans; Insulin; Insulin Resistance; Male; Monosaccharide Transport Proteins; Muscle Proteins; Rats; Transfection | 1997 |
Troglitazone prevents hyperglycemia-induced but not glucosamine-induced insulin resistance.
Topics: Administration, Oral; Animals; Blood Glucose; Chromans; Cohort Studies; Glucosamine; Glucose Clamp Technique; Hormone Antagonists; Hypoglycemic Agents; Infusion Pumps; Insulin Resistance; Male; Rats; Rats, Sprague-Dawley; Somatostatin; Thiazoles; Thiazolidinediones; Troglitazone | 1998 |
Glucosamine-induced insulin resistance in 3T3-L1 adipocytes is caused by depletion of intracellular ATP.
Topics: 3T3 Cells; Adenosine Triphosphate; Adipocytes; Animals; Cell Fractionation; Deoxyglucose; Glucosamine; Glucose; Glucose Transporter Type 1; Glucose Transporter Type 4; Inosine; Insulin Receptor Substrate Proteins; Insulin Resistance; Mice; Monosaccharide Transport Proteins; Muscle Proteins; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptor Protein-Tyrosine Kinases; Receptor, Insulin; Sodium Azide | 1998 |
Induction of insulin resistance by glucosamine reduces blood flow but not interstitial levels of either glucose or insulin.
Topics: Animals; Extracellular Space; Female; Glucosamine; Glucose; Insulin; Insulin Resistance; Microdialysis; Muscle, Skeletal; Rats; Rats, Sprague-Dawley; Regional Blood Flow | 1999 |
Allosteric regulation of glycogen synthase and hexokinase by glucosamine-6-phosphate during glucosamine-induced insulin resistance in skeletal muscle and heart.
Topics: Allosteric Regulation; Animals; Blood Glucose; Enzyme Activation; Enzyme Inhibitors; Glucosamine; Glucose Clamp Technique; Glucose-6-Phosphate; Glycogen; Glycogen Synthase; Glycolysis; Heart; Hexokinase; Insulin; Insulin Resistance; Male; Muscle, Skeletal; Myocardium; Rats; Rats, Wistar | 1999 |
Glucose tolerance and insulin resistance in the JCR:LA-corpulent rat: effect of miglitol (Bay m1099).
Topics: 1-Deoxynojirimycin; Animals; Blood Glucose; Body Weight; Disease Models, Animal; Eating; Enzyme Inhibitors; Glucosamine; Glucose Tolerance Test; Glycoside Hydrolase Inhibitors; Hypoglycemic Agents; Imino Pyranoses; Insulin; Insulin Resistance; Lipids; Male; Obesity; Postprandial Period; Rats | 1999 |
Activation of the hexosamine pathway by glucosamine in vivo induces insulin resistance of early postreceptor insulin signaling events in skeletal muscle.
Topics: Animals; Enzyme Activation; Glucosamine; Glycosylation; Hexosamines; Insulin; Insulin Resistance; Lipid Metabolism; Male; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases; Protein Isoforms; Rats; Rats, Wistar; Receptor, Insulin; Signal Transduction; Tyrosine | 1999 |
Glucosamine in osteoarthritis.
Topics: Administration, Oral; Animals; Glucosamine; Humans; Infusions, Intravenous; Insulin Resistance; Osteoarthritis; Rats | 1999 |
Differential effects of troglitazone and D-chiroinositol on glucosamine-induced insulin resistance in vivo in rats.
Topics: Animals; Chromans; Glucosamine; Glucose Clamp Technique; Hypoglycemic Agents; Inositol; Insulin Resistance; Male; Rats; Rats, Wistar; Thiazoles; Thiazolidinediones; Time Factors; Troglitazone | 1999 |
Glucosamine-induced insulin resistance in 3T3-L1 adipocytes.
Topics: 3T3 Cells; Adipocytes; Animals; Cell Membrane; Deoxyglucose; Dose-Response Relationship, Drug; Glucosamine; Glucose Transporter Type 4; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Intracellular Signaling Peptides and Proteins; Mice; Monosaccharide Transport Proteins; Muscle Proteins; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptor, Insulin; Ribosomal Protein S6 Kinases; Tyrosine | 2000 |
Effects of insulin on prenylation as a mechanism of potentially detrimental influence of hyperinsulinemia.
Topics: Adult; Animals; Dogs; Female; Glucosamine; Humans; Hyperinsulinism; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Mutant Strains; Middle Aged; Phosphoproteins; Protein Prenylation; Proto-Oncogene Proteins p21(ras); Rats; rhoA GTP-Binding Protein | 2000 |
High glucose and glucosamine induce insulin resistance via different mechanisms in 3T3-L1 adipocytes.
Topics: 3T3 Cells; Adipocytes; Animals; Biological Transport; Dose-Response Relationship, Drug; Galactosamine; Glucosamine; Glucose; Glucose Transporter Type 4; Insulin Resistance; Mice; Monosaccharide Transport Proteins; Muscle Proteins; Nucleotides; Phosphatidylinositol 3-Kinases | 2000 |
Development and comparison of two 3T3-L1 adipocyte models of insulin resistance: increased glucose flux vs glucosamine treatment.
Topics: 3T3 Cells; Adipocytes; Amino Acid Sequence; Animals; Biological Transport; Glucosamine; Glucose; Glucose Transporter Type 4; Insulin; Insulin Resistance; Kinetics; Mice; Models, Biological; Molecular Sequence Data; Monosaccharide Transport Proteins; Muscle Proteins; N-Acetylglucosaminyltransferases; Platelet-Derived Growth Factor; Signal Transduction; Transaminases; Tyrosine | 2000 |
Effects of cellular ATP depletion on glucose transport and insulin signaling in 3T3-L1 adipocytes.
Topics: 3T3 Cells; Adenosine Triphosphate; Adipocytes; Animals; Biological Transport; Cell Membrane; Dinitrophenols; Electron Transport; Glucosamine; Glucose; Glucose Transporter Type 1; Guanosine; Hexokinase; Insulin; Insulin Resistance; Mice; Mitochondria; Monosaccharide Transport Proteins; Oxidative Phosphorylation; Signal Transduction; Sodium Azide | 2001 |
Free fatty acids induce peripheral insulin resistance without increasing muscle hexosamine pathway product levels in rats.
Topics: Animals; Drug Combinations; Fat Emulsions, Intravenous; Fatty Acids, Nonesterified; Glucosamine; Glucose; Hexosamines; Insulin; Insulin Resistance; Male; Muscle, Skeletal; Rats; Rats, Wistar | 2001 |
Hyperglycemia modulates angiotensinogen gene expression.
Topics: Adipose Tissue; Angiotensinogen; Animals; Blood Glucose; Body Composition; Body Weight; Gene Expression Regulation; Glucosamine; Glucose Clamp Technique; Hexosamines; Hyperglycemia; Hyperinsulinism; Infusions, Intravenous; Insulin; Insulin Resistance; Liver; Male; Obesity; Rats; Rats, Sprague-Dawley | 2001 |
Effects of oral glucosamine and chondroitin sulfate alone and in combination on the metabolism of SHR and SD rats.
Topics: Administration, Oral; Animals; Blood Glucose; Blood Pressure; Body Weight; Chondroitin Sulfates; Glucosamine; Glucose; Hypertension; Insulin Resistance; Male; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Time Factors | 2001 |
Hyperglycemia induces PAI-1 gene expression in adipose tissue by activation of the hexosamine biosynthetic pathway.
Topics: Adipose Tissue; Animals; Biotransformation; Blood Glucose; Body Composition; Body Weight; Gene Expression Regulation; Glucosamine; Hexosamines; Hyperglycemia; Insulin; Insulin Resistance; Male; Plasminogen Activator Inhibitor 1; Rats; Rats, Sprague-Dawley; Sodium Chloride | 2002 |
Defective Akt activation is associated with glucose- but not glucosamine-induced insulin resistance.
Topics: 3T3 Cells; Adipocytes; Animals; Biological Transport; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Glucosamine; Glucose; Glucose Transporter Type 4; Immunoblotting; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Mice; Monosaccharide Transport Proteins; Muscle Proteins; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt | 2002 |
Glucose transport by osmotic shock and vanadate is impaired by glucosamine.
Topics: Adipocytes; Animals; Biological Transport; Cell Line; Deoxyglucose; Glucosamine; Glucose; Insulin; Insulin Resistance; Kinetics; Mice; Osmotic Pressure; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Vanadates | 2002 |
Elevated nucleocytoplasmic glycosylation by O-GlcNAc results in insulin resistance associated with defects in Akt activation in 3T3-L1 adipocytes.
Topics: 3T3 Cells; Acetylglucosamine; Adipocytes; Animals; beta Catenin; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Catalysis; Cell Line; Cell Nucleus; Cytoplasm; Cytoskeletal Proteins; Dose-Response Relationship, Drug; Enzyme Activation; Glucosamine; Glucose; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Glycosylation; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Mice; Oximes; Phenylcarbamates; Phosphoproteins; Phosphorylation; Precipitin Tests; Protein Binding; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction; Time Factors; Trans-Activators; Tyrosine | 2002 |
Discovery of a metabolic pathway mediating glucose-induced desensitization of the glucose transport system. Role of hexosamine biosynthesis in the induction of insulin resistance.
Topics: Animals; Azaserine; Biological Transport; Glucosamine; Glucose; Glutamine; Hexosamines; Insulin Resistance; Male; Rats; Rats, Inbred Strains | 1991 |