gluconasturtiin and Cell-Transformation--Neoplastic

gluconasturtiin has been researched along with Cell-Transformation--Neoplastic* in 1 studies

Other Studies

1 other study(ies) available for gluconasturtiin and Cell-Transformation--Neoplastic

Article	Year
In vitro induction of benzo(a)pyrene cell-transforming activity by the glucosinolate gluconasturtiin found in cruciferous vegetables. Cancer letters, 2002, Oct-08, Volume: 184, Issue:1 Cytotoxic and cell-transforming activity of gluconasturtiin (GNST), a promising chemopreventive agent commonly found in human diet, was studied in a medium-term bioassay utilizing BALB/c 3T3 cells. We also assessed whether GNST coupled with myrosinase, thus yielding product phenylethyl isothiocyanate (as shown by gas chromatography-mass spectral analysis), can affect the transforming potential of benzo(a)pyrene (B(a)P). Neither cytotoxicity nor cell-transforming activity was recorded. On the contrary, a marked increase (up to sevenfold) of the transforming activity of B(a)P was seen. This cocarcinogenic potential could be ascribed to an imbalance among bioactivation/detoxication during cell growth. These results indicate the need for an overall toxicological characterization of a chemopreventive agent prior to large-scale use. Topics: 3T3 Cells; Aldehyde Dehydrogenase; Animals; Benzo(a)pyrene; Brassica; Carcinogens; Cell Survival; Cell Transformation, Neoplastic; Cocarcinogenesis; Drug Synergism; Glucosinolates; Glycoside Hydrolases; In Vitro Techniques; Isothiocyanates; Mice; Mice, Inbred BALB C; Risk Factors	2002

Article

Year

In vitro induction of benzo(a)pyrene cell-transforming activity by the glucosinolate gluconasturtiin found in cruciferous vegetables.

Cancer letters, 2002, Oct-08, Volume: 184, Issue:1

Cytotoxic and cell-transforming activity of gluconasturtiin (GNST), a promising chemopreventive agent commonly found in human diet, was studied in a medium-term bioassay utilizing BALB/c 3T3 cells. We also assessed whether GNST coupled with myrosinase, thus yielding product phenylethyl isothiocyanate (as shown by gas chromatography-mass spectral analysis), can affect the transforming potential of benzo(a)pyrene (B(a)P). Neither cytotoxicity nor cell-transforming activity was recorded. On the contrary, a marked increase (up to sevenfold) of the transforming activity of B(a)P was seen. This cocarcinogenic potential could be ascribed to an imbalance among bioactivation/detoxication during cell growth. These results indicate the need for an overall toxicological characterization of a chemopreventive agent prior to large-scale use.

Topics: 3T3 Cells; Aldehyde Dehydrogenase; Animals; Benzo(a)pyrene; Brassica; Carcinogens; Cell Survival; Cell Transformation, Neoplastic; Cocarcinogenesis; Drug Synergism; Glucosinolates; Glycoside Hydrolases; In Vitro Techniques; Isothiocyanates; Mice; Mice, Inbred BALB C; Risk Factors

2002