glucagon-like-peptide-1 and Scoliosis

glucagon-like-peptide-1 has been researched along with Scoliosis* in 1 studies

Other Studies

1 other study(ies) available for glucagon-like-peptide-1 and Scoliosis

ArticleYear
Dipeptidyl Peptidase-4 and Adolescent Idiopathic Scoliosis: Expression in Osteoblasts.
    Scientific reports, 2017, 06-09, Volume: 7, Issue:1

    It has been proposed that girls with adolescent idiopathic scoliosis (AIS) tend to have a taller stature and a lower body mass index. Energy homeostasis, that is known to affect bone growth, could contribute to these characteristics. In circulation, dipeptidyl peptidase-4 (DPP-4) inactivates glucagon-like peptide-1 (GLP-1), an incretin that promotes insulin secretion and sensitivity. Our objectives were to investigate DPP-4 status in plasma and in osteoblasts of AIS subjects and controls and to evaluate the regulatory role of metabolic effectors on DPP-4 expression. DPP-4 activity was assessed in plasma of 113 girls and 62 age-matched controls. Osteoblasts were isolated from bone specimens of AIS patients and controls. Human cells were incubated with glucose, insulin, GLP-1 and butyrate. Gene and protein expressions were evaluated by RT-qPCR and Western blot. Our results showed 14% inferior plasma DPP-4 activity in AIS patients when compared to healthy controls (Pā€‰=ā€‰0.0357). Similarly, osteoblasts derived from AIS subjects had lower DPP-4 gene and protein expression than controls by 90.5% and 57.1% respectively (Pā€‰<ā€‰0.009). DPP-4 expression was regulated in a different manner in osteoblasts isolated from AIS participants compared to controls. Our results suggest a role for incretins in AIS development and severity.

    Topics: Adolescent; Body Mass Index; Butyrates; Child; Dipeptidyl Peptidase 4; Energy Metabolism; Female; Gene Expression Regulation, Enzymologic; Glucagon-Like Peptide 1; Glucose; Humans; Incretins; Insulin; Osteoblasts; Scoliosis

2017