glucagon-like-peptide-1-(1-37) and Insulinoma

glucagon-like-peptide-1-(1-37) has been researched along with Insulinoma* in 1 studies

Other Studies

1 other study(ies) available for glucagon-like-peptide-1-(1-37) and Insulinoma

ArticleYear
Glucagonlike peptide-1(7-36)amide suppresses glucagon secretion and decreases cyclic AMP concentration in cultured In-R1-G9 cells.
    Biochemical and biophysical research communications, 1992, Jul-15, Volume: 186, Issue:1

    We previously reported that GLP-1(7-36)amide had glucagonostatic action as well as insulinotropic action in the perfused rat pancreas. In this study, we examined the effect of GLP-1(7-36)amide on glucagon secretion and cAMP concentration in glucagon-secreting cell line, In-R1-G9. GLP-1(7-36)amide (1nM) significantly suppressed glucagon secretion and decreased cAMP concentration in the cells. GLP-1(1-37) did not affect glucagon secretion. It is suggested that inhibitory effect of GLP-1(7-36)amide on glucagon secretion is at least partly mediated by adenylate cyclase system.

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Clone Cells; Cricetinae; Cyclic AMP; Dose-Response Relationship, Drug; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Insulinoma; Kinetics; Pancreatic Neoplasms; Peptide Fragments; Peptides

1992