Page last updated: 2024-09-04

glucagon and Insulinoma

glucagon has been researched along with Insulinoma in 180 studies

Research

Studies (180)

TimeframeStudies, this research(%)All Research%
pre-199061 (33.89)18.7374
1990's77 (42.78)18.2507
2000's26 (14.44)29.6817
2010's12 (6.67)24.3611
2020's4 (2.22)2.80

Authors

AuthorsStudies
Midkiff, CC; Saied, AA; Shroyer, MN; Taylor, JM1
de Herder, WW; Klöppel, G1
Bloch, CP; Harris, ME; Weatherton, L1
Miyazaki, JI; Miyazaki, S; Sasaki, K; Tashiro, F; Tsuchiya, T1
Jung, H; Kim, MK; Kim, TK; Kim, TN; Kwon, MJ; Lee, E; Lee, SH; Park, JH; Rhee, BD; Shin, HM1
Agin, A; Charrie, A; Chikh, K; Tabarin, A; Vezzosi, D1
Bennett, KR; Gaunt, MC; Parker, DL1
Deng, T; Fang, N; Fang, Q; Hua, Z; Liu, H; Lou, J; Peng, L; Wang, P; Wang, Z; Xu, S; You, J; Zhang, W1
Caldwell, D; Chen, Q; Coughlan, MC; Florian, M; Fu, A; Jin, X; Lalande, M; Laziyan, M; Mailloux, R; Patry, D; Petrov, I; Wang, GS; Willmore, W; Yan, J1
Fujimori, N; Igarashi, H; Ito, T; Jensen, RT; Kawabe, K; Lee, L; Oda, Y; Tachibana, Y; Takayanagi, R; Ueda, K1
Bertolino, P; Bonnavion, R; Calender, A; Carreira, C; Herrera, PL; Lu, J; Seigne, C; Zhang, CX1
Adem, A; Hewitt, SM; Libutti, SK; Pechhold, K; Shen, HC; Wilson, A; Ylaya, K1
Batcher, E; Gianoukakis, AG; Madaj, P1
Felício, JS; Kalinin, L; Liberman, B; Machado, MC; Martins, CL; Mileo, KB; Nery, M; Semer, M1
Menger, MD; Müller, I; Rössler, OG; Thiel, G; Wittig, C1
Isogawa, A; Kishi, S; Mori, M; Sakamoto, K; Shiba, T1
Filipsson, K; Jing, XJ; Reimer, MK; Renström, E; Rosengren, A1
Bousquet, C; Hui, H; Perfetti, R; Yu, R1
Mentlein, R; Stark, A1
Hui, H; Nourparvar, A; Perfetti, R; Zhao, X1
DE LOOSE, F; DEDULLEN, G; ELEWAUT, A1
BECK-CHRISTIANSEN, O1
MARKS, V; MARRACK, D; ROSE, FC1
Tomita, T1
Arita, Y; Ito, T1
Clynes, M; Gammell, P; O'Driscoll, L1
Islam, KB; Islam, MS; Mirzaei, Z; Rahman, SA1
Keller, U; Perren, A; Pfammatter, T; Schmid, C; Spinas, GA; Wiesli, P1
Bollheimer, LC; Buettner, R; Ottinger, I; Rockmann, F; Schölmerich, J; Wrede, CE1
Mol, JA; Rijnberk, A; Robben, JH; van den Brom, WE; van Haeften, TW1
Bermano, G; Docherty, K; Durward, E; Hay, CW; Sinclair, EM; Tadayyon, M1
Hirata, Y; Ishizawa, M; Nishida, K; Sugiyama, T; Takada, Y; Takanishi, K; Tsujino, M1
Couvelard, A; Fregeville, A; Paradis, V; Vilgrain, V; Warshauer, DM1
Adukauskiene, D; Blauzdyte, J1
Kawaoi, A; Koyama, H; Kumae, S; Nakamura, M; Ono, J; Takaki, R; Yokogawa, Y1
Függer, R; Funovics, J; Schulz, F; Ulrich, W; Zöch, G1
Chick, WL; Hales, CN; Hutton, JC; Naber, SP; Sopwith, AM1
Neumayr, A1
Bauer, GE; Dixit, PK; Johnson, DE; Michels, JE1
Ferguson, DC; Hoenig, M; Matschinsky, FM2
Christova, T; Daskalova, R; Georgiev, C; Sivtchev, S; Zafirova, M1
Hedeskov, CJ; Knudsen, P; Kofod, H; Lernmark, A1
Stacpoole, PW1
Ericsson, M; Holst, J; Ingemansson, S; Järhult, J1
Barczyk, J; Kinalska, I; Puchalski, Z; Triebling, A1
Kobayashi, T; Nihei, J; Ohneda, A1
Cowan, RG; McCann, JP; Reimers, TJ; Ross, MW1
Kobayashi, T; Nihei, J; Ohneda, A; Sakai, T2
Atsmon, A; Blum, I; Doron, M; Lahav, M; Laron, Z; Rusecki, Y1
Andreani, D; Lala, A; Leonetti, F; Libianchi, S; Mauceri, M; Tamburrano, G1
Berger, M; Tsotsalas, M1
Berchtold, P; Berger, M; Bordi, C; Cüppers, HJ; Gries, FA; Münterfering, H; Orci, L; Sailer, R; Zimmermann, H1
Bloom, SR; Polak, JM; Wood, SM1
Hehmke, B; Kohnert, KD; Ulrich, FE; Woltanski, KP; Zühlke, H1
Kajikawa, K; Katsuda, S; Konishi, K; Miwa, K; Nakanishi, I; Yonemura, Y1
Bonser, AM; Garcia-Webb, P1
Bode, HP; Göke, B; Göke, R; Lankat-Buttgereit, B; van Eyll, B1
Habener, JF; Holz, GG; Leech, CA1
Egan, JM; Montrose-Rafizadeh, C; Nadiv, O; Raygada, M; Roth, J; Wang, Y1
Bode, HP; Fehmann, HC; Göke, B; Göke, R; Lankat-Buttgereit, B; Volz, A1
Avogaro, A; del Prato, S; Dorella, M; Marescotti, MC; Riccio, A; Tiengo, A; Vigili de Kreutzenberg, S1
Göke, B; Göke, R; McGregor, GP1
Bokvist, K; Dissing, S; Frøkjaer-Jensen, J; Gromada, J; Renström, E; Rorsman, P; Wulff, BS1
Fehmann, HC; Gherzi, R; Göke, B; Ponassi, M; Volz, A1
Araki, E; Isami, S; Jinnouchi, H; Kisanuki, K; Kishikawa, H; Miyamura, N; Shichiri, M; Shirotani, T; Uehara, M; Ura, S1
Biswas, C; Brady, EJ; Conti, M; Cullinan, CA; Hayes, NS; Leibowitz, MD; Manganiello, VC; Saperstein, R; Wang, LH; Zafian, PT1
Funakoshi, A; Iwamoto, N; Matsuoka, Y; Shima, K; Tateishi, K; Yasunami, Y1
Kuwajima, M; Matsumura, T; Matsuzawa, Y; Mineo, I; Namba, M; Shingu, R1
Eckart, K; Fölsch, UR; Gallwitz, B; Morys-Wortmann, C; Paetzold, G; Schmidt, WE; Witt, M; Zimmermann, B1
Briata, P; Fehmann, HC; Gherzi, R; Göke, B1
Egan, JM; Montrose-Rafizadeh, C; Roth, J1
D'Alessandro, B; Esposito, D; Esposito, V; Lo Iudice, G; Rispoli, C; Verrillo, A1
Aunis, D; Bader, MF; Bargsten, G; Cetin, Y; Galindo, E; Grube, D; Jörns, A1
Challis, DR; Davies, PF; McArdle, JP; Shepherd, JJ; Teh, BT; Wilkinson, S1
Fehmann, HC; Göke, B; Göke, R; Jiang, J; Lankat-Buttgereit, B; Stöckmann, F1
Kawai, K; Ohashi, S; Suzuki, S; Watanabe, Y; Yamashita, K; Yokota, C1
Buettger, C; Epstein, AJ; Hang, TL; Matschinsky, FM; Ronner, P1
O'Brien, PC; O'Brien, T; Service, FJ1
Atillasoy, EJ; Burtis, WJ; Gaich, G; Ganz, MB; Orloff, JJ; Stewart, AF1
Brunner, HR; Grouzmann, E; Nicod, P; Thompson, N; Waeber, B; Waeber, G1
Eng, J; Fehmann, HC; Göke, B; Göke, R; Krause, M; Linn, T; Schmidt, H1
Fujikawa, J; Imamura, M; Imura, H; Inoue, K; Kadowaki, S; Kojima, H; Seino, Y; Yamamoto, T1
Andersson, DE; Eriksson, B; Stridsberg, M; Svartberg, J; Wilander, E1
Abrahamsen, N; Froguel, P; Hager, J; Hansen, LH; Jelinek, L; Kindsvogel, W; Nishimura, E1
Dissing, S; Gromada, J; Rorsman, P1
Fölsch, UR; Gallwitz, B; Morys-Wortmann, C; Schmidt, WE; Witt, M1
O'Dorisio, TM; Thompson, CS; Woltering, EA1
Boissard, C; Breant, B; Marie, JC; Rosselin, G; Skoglund, G1
Thorens, B; Widmann, C1
Göke, B; Göke, R; Steffen, H1
Ahrén, B; Karlsson, S; Simonsson, E1
Dolci, W; Thorens, B; Widmann, C1
Adler, G; Fussgänger, RD; Jehle, D; Jehle, PM1
Fehmann, HC; Göke, B; Jiang, J; Pitt, D; Schweinfurth, J1
Fatourechi, V; Kvols, LK; Wermers, RA1
Jensen, CH; Larsson, LI; Teisner, B; Tornehave, D1
Furmanenko, ED; Kozhara, SP; Lifshits, IuZ; Usenko, AIu1
Deeg, MA; Verchere, CB1
Fujisawa, T; Hamada, Y; Ikegami, H; Nakagawa, Y; Ogihara, T; Takekawa, K; Ueda, H; Yamato, E1
Andrews, GA; Chard-Bergstrom, C; Myers, NC1
Göke, B; Göke, R; Hupe-Sodmann, K; McGregor, GP; Thole, HH; Voigt, K; Zimmermann, B1
Göke, B; Lankat-Buttgereit, B1
Bishof-Delaloye, A; Centeno, G; Chaubert, P; Francke, ML; Gomez, F; Haefliger, JA; Nicod, P; Scherrer, U; Temler, E; Waeber, G1
Birkeland, K; Jorde, R; Revhaug, A; Sager, G; Sundsfjord, J; Trovik, TS; Vea, H1
Kostenko, AA1
Totsuka, Y1
Compton, DS; Davis, HR; France, CF; Graziano, MP; Hoos, LM; Mullins, DE; Pines, JM; Strader, CD; Sybertz, EJ; Van Heek, M1
Hoff, AO; Vassilopoulou-Sellin, R1
Bernstein, IL; D'Alessio, D; Eng, J; Seeley, RJ; Thiele, TE; van Dijk, G; Woods, SC1
Galehshahi, FS; Göke, B; Lankat-Buttgereit, B1
Bloom, SR; Ghatei, MA; Hurley, JD; Karlsen, AE; Kulkarni, RN; Morgan, DG; Smith, DM; Wang, RM; Wang, ZL1
Mamujee, SN; Sun, AM; Vacek, I; Wheeler, MB; Zhou, D1
Cahill, CM; Doyle, ME; Egan, JM; Piñeyro, MA; Wang, X; Zhou, J1
Gallwitz, B; Mentlein, R; Morys-Wortmann, C; Ropeter, T; Schmidt, WE; Siegel, EG1
Kobayashi, T; Ogawa, S; Yanagi, H; Yura, T1
Ebinger, M; Fehmann, HC; Fussgaenger, RD; Jehle, DR; Jehle, PM1
Aust, G; Nguyen, TB; Scherbaum, WA; Seissler, J; Steinbrenner, H1
Holz, GG; Hussain, MA; Skoglund, G1
Hori, S; Kondo, H; Nakagaki, I; Sasaki, S1
Hagenfeldt, KA; Ishihara, H; Maechler, P; Philippe, J; Ritz-Laser, B; Wang, H; Wollheim, CB1
Chepurny, OG; Holz, GG1
Bhagroo, NV; Brelje, TC; Sorenson, RL; Stout, LE; Svensson, AM1
Breslin, MB; Lan, MS; Zhu, M1
Béhé, M; Behr, TM; Fischer, M; Fritsch, HW; Göke, B; Gotthardt, M; Holz, JB; Joseph, K; Jungclas, H; Naeher, I1
Fehmann, HC; Habener, JF3
Göke, B; Göke, R; Oltmer, B; Sheikh, SP1
Bataille, D; Demirpence, E; Gros, L; Jarrousse, C; Kervran, A1
Itoh, H; Komatsu, R; Kono, N; Matsumura, T; Matsuyama, T; Matsuzawa, Y; Namba, M; Oda, Y; Tanaka, M; Watanabe, N1
Maeda, S; Nakamura, T; Satonaka, K1
Stehouwer, C1
Besch, W; Hehmke, B; Köhler, E; Lucke, S; Schlosser, M; Witt, S; Ziegler, B; Ziegler, M1
Bataille, D; Estival, A; Jarrousse, C; Le Quellec, A; Martinez, J; Pradayrol, L; Sladeczek, F; Tani, T1
Chafitz, JA; Habener, JF; Knepel, W; Vallejo, M1
Brubaker, PL; Campos, RV; Drucker, DJ; Stobie, KM; Wang, C1
Creutzfeldt, W; Nauck, MA; Siegel, EG1
Betsholtz, C; Madsen, OD; Michelsen, B; Nielsen, JH; Nishi, M; Steiner, DF; Westermark, P1
Flatt, PR; Hampton, SM; Marks, V; Shiber, O1
Broderick, CL; Brooke, GS; DiMarchi, RD; Gold, G1
Gefel, D; Habener, J; Hendrick, GK; Mojsov, S; Weir, GC1
Habener, JF; Jepeal, L; Knepel, W1
Arnold, R; Göke, B; Göke, R; Richter, G1
Danoff, A; Fleischer, N; Pasmantier, R; Schubart, UK1
Bertrand, J; Demidem, A; Durand, A; Haftek, M; Thivolet, CH1
Guillemin, R; Leppäluoto, J; Ling, N; Ueno, N; Ying, SY; Zeytin, F1
Fischer, HR; Hackeng, WH; Lems, WF; Naafs, MA; Stehouwer, CD1
Cole, T; Conlon, JM; Göke, R1
Arnold, R; Fehmann, HC; Göke, B; Göke, R; Haus, E; Richter, G; Trautmann, ME1
Arnold, R; Göke, B; Göke, R; Richter, G; Trautmann, M1
Funakoshi, A; Ishii, H; Jimi, A; Konomi, K; Miyazaki, K; Nawata, H1
Bani Sacchi, T; Bani, D; Biliotti, G1
Fehmann, HC; Göke, B; Göke, R; Richter, G; Trautmann, M1
Nielsen, JH; Orskov, C1
Conlon, JM; Göke, R1
Asano, T; Okeda, T; Ono, J; Takaki, R; Yamaguchi, K1
Ho, PW; Pun, KK; Tam, CF; Wang, C; Young, RT1
Bloom, SR; Williams, SJ; Wynick, D1
Amblard, P; Béani, JC; Benhamou, PY; Boizel, R; Reymond, JL1
Dubitskiĭ, AE; Furmanenko, ED; Kozhara, SP1
Goudswaard, WB; Houthoff, HJ; Koudstaal, J; Zwierstra, RP1
Hamaguchi, K; Hiraoka, T; Kumae, S; Nakamura, M; Ono, J; Takaki, R; Uchida, S; Yamaguchi, K; Yokogawa, Y1
Bailey, CJ; Flatt, PR; Marks, V; Powell, CJ; Swanston-Flatt, SK; Tan, KS1
Chick, WL; Habener, JF; Philippe, J1
Flatt, PR; Marks, V; Swanston-Flatt, SK; Tan, KS; Webster, JD1
Schonbrunn, A; Sullivan, SJ1
Longnecker, SM1
Comi, R; Drucker, DJ; Habener, JF; Mojsov, S; Philippe, J; Powers, AC1
Hiraoka, T; Murata, E; Tashiro, S1
Bhathena, SJ; Korman, LY; Oie, HK; Recant, L; Voyles, NR1
Carlo Stella, C; De Caro, L; Ghizzi, A; Gorini, M1
Chiba, T; Chihara, K; Fujita, T; Kinoshita, Y; Kondo, T; Kotoura, Y; Nonaka, H; Suzuki, S; Yamamura, T1
Andreu, M; Greaves, P; Spencer, AJ1
Kumae, S; Ono, J; Sato, Y; Takaki, R1
Bailey, CJ; Conlon, JM; Deacon, CF; Flatt, PR1
Kurihara, Y1
Drucker, DJ; Mojsov, S; Philippe, J1
Fehmann, HC; Göke, B; Strowski, M1

Reviews

9 review(s) available for glucagon and Insulinoma

ArticleYear
One hundred years after the discovery of insulin and glucagon: the history of tumors and hyperplasias that hypersecrete these hormones.
    Endocrine-related cancer, 2023, 09-01, Volume: 30, Issue:9

    Topics: Animals; Dogs; Glucagon; Hyperplasia; Insulin; Insulinoma; Pancreatic Neoplasms

2023
Pancreatic neuroendocrine tumors.
    Endocrine research, 2011, Volume: 36, Issue:1

    Topics: Gastrinoma; Gastrins; Glucagon; Glucagonoma; Hormones; Humans; Hypoglycemia; Insulinoma; Neuroendocrine Tumors; Pancreatic Neoplasms; Somatostatinoma; Vasoactive Intestinal Peptide; Vipoma

2011
[Diagnosis and treatment of insulinoma].
    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 2004, Volume: 101, Issue:4

    Topics: Antineoplastic Agents; Blood Glucose; Chemoembolization, Therapeutic; Diazoxide; Fasting; Glucagon; Humans; Insulinoma; Magnetic Resonance Imaging; Maleic Anhydrides; Multiple Endocrine Neoplasia Type 1; Pancreatic Neoplasms; Polystyrenes; Somatostatin; Tomography, X-Ray Computed; Zinostatin

2004
[Causes, diagnosis, and treatment of hypoglycemia].
    Medicina (Kaunas, Lithuania), 2006, Volume: 42, Issue:10

    Topics: Adolescent; Adult; Aged; Algorithms; Anti-Inflammatory Agents; Blood Glucose; Child; Diabetes Complications; Diagnosis, Differential; Female; Glucagon; Glucose; Glucose Tolerance Test; Homeostasis; Humans; Hydrocortisone; Hypoglycemia; Insulin; Insulin Secretion; Insulinoma; Male; Middle Aged; Pancreatic Neoplasms

2006
The glucagonoma syndrome: clinical features, diagnosis, and treatment.
    Endocrine reviews, 1981,Summer, Volume: 2, Issue:3

    Topics: Adenoma, Islet Cell; Adult; Amino Acids; Diagnosis, Differential; Female; Glucagon; Glucagonoma; Humans; Hyperglycemia; Insulinoma; Male; Middle Aged; Pancreatic Neoplasms; Paraneoplastic Endocrine Syndromes; Skin

1981
Gut hormone secreting tumours.
    Scandinavian journal of gastroenterology. Supplement, 1983, Volume: 82

    Topics: Adenoma, Islet Cell; Bombesin; Bronchial Neoplasms; C-Peptide; Carcinoma, Small Cell; Diagnosis, Differential; Endocrine System Diseases; Erythema; Gastrointestinal Hormones; Glucagon; Glucagonoma; Humans; Insulin; Insulin Secretion; Insulinoma; Male; Neoplasms; Neurotensin; Pancreatic Hormones; Pancreatic Neoplasms; Pancreatic Polypeptide; Somatostatinoma; Vasoactive Intestinal Peptide; Zollinger-Ellison Syndrome

1983
C-peptide measurement and its clinical usefulness: a review.
    Annals of clinical biochemistry, 1981, Volume: 18, Issue:Pt 4

    Topics: Adolescent; Adult; Aged; Blood Glucose; C-Peptide; Diabetes Mellitus; Diabetes Mellitus, Type 1; Female; Glucagon; Humans; Hypoglycemia; Infant, Newborn; Insulin; Insulinoma; Islets of Langerhans; Kidney Function Tests; Middle Aged; Peptides; Radioimmunoassay

1981
Tumour-induced hypoglycaemia in a patient with insulin-dependent diabetes mellitus.
    Journal of internal medicine, 1996, Volume: 239, Issue:2

    Topics: Adult; Amyloid; Diabetes Mellitus, Type 1; Diagnosis, Differential; Fatal Outcome; Female; Glucagon; Humans; Hypoglycemia; Insulin; Insulinoma; Islet Amyloid Polypeptide; Pancreatic Neoplasms

1996
[Glucagonoma and somatostatinoma].
    Nihon rinsho. Japanese journal of clinical medicine, 1998, Volume: 56 Suppl 3

    Topics: Glucagon; Glucagonoma; Glucose; Humans; Insulin; Insulin Secretion; Insulinoma; Pancreatic Neoplasms; Somatostatinoma

1998

Trials

2 trial(s) available for glucagon and Insulinoma

ArticleYear
Effect of octreotide on plasma concentrations of glucose, insulin, glucagon, growth hormone, and cortisol in healthy dogs and dogs with insulinoma.
    Research in veterinary science, 2006, Volume: 80, Issue:1

    Topics: Animals; Blood Glucose; Dog Diseases; Dogs; Glucagon; Growth Hormone; Health; Hydrocortisone; Insulin; Insulinoma; Octreotide

2006
Calcium reverses octreotide inhibition of insulin and glucagon levels in patients with insulinoma and glucagonoma.
    Digestion, 1996, Volume: 57 Suppl 1

    Topics: Antineoplastic Agents, Hormonal; Calcium; Glucagon; Glucagonoma; Humans; Hypoglycemic Agents; Infusions, Intravenous; Insulin; Insulinoma; Octreotide; Pancreatic Neoplasms; Secretin; Tolbutamide

1996

Other Studies

169 other study(ies) available for glucagon and Insulinoma

ArticleYear
Functional Insulinomas in a Rhesus Macaque (Macaca mulatta).
    Journal of comparative pathology, 2022, Volume: 198

    Topics: Animals; Chromogranin A; Female; Gastrins; Glucagon; Glucose; Hypoglycemic Agents; Insulinoma; Insulins; Macaca mulatta; Pancreatic Neoplasms; Pancreatic Polypeptide; Somatostatin; Sugars; Synaptophysin

2022
Glucagon therapy in canines with an insulinoma: A retrospective descriptive study of 11 dogs.
    The Canadian veterinary journal = La revue veterinaire canadienne, 2020, Volume: 61, Issue:7

    Topics: Animals; Blood Glucose; Dog Diseases; Dogs; Euthanasia, Animal; Glucagon; Insulin; Insulinoma; Pancreatic Neoplasms; Retrospective Studies

2020
Establishment of a long-term stable β-cell line and its application to analyze the effect of Gcg expression on insulin secretion.
    Scientific reports, 2021, 01-12, Volume: 11, Issue:1

    Topics: Animals; Female; Glucagon; Glucagon-Like Peptide-1 Receptor; Insulin Secretion; Insulin-Secreting Cells; Insulinoma; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Knockout; Pancreatic Neoplasms

2021
Comparison of pancreatic beta cells and alpha cells under hyperglycemia: Inverse coupling in pAkt-FoxO1.
    Diabetes research and clinical practice, 2017, Volume: 131

    Topics: Adenoma; Animals; Cell Line, Tumor; Cell Proliferation; Diabetes Mellitus, Type 2; Forkhead Box Protein O1; Glucagon; Glucagon-Secreting Cells; Glucose; Hydrogen Peroxide; Hyperglycemia; Insulin; Insulin Secretion; Insulin-Secreting Cells; Insulinoma; Mice; Pancreatic Neoplasms; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt

2017
Fast test: clinical practice and interpretation.
    Annales d'endocrinologie, 2013, Volume: 74, Issue:3

    Topics: Blood Glucose; Decision Trees; Diagnosis, Differential; Diagnostic Techniques, Endocrine; Fasting; Glucagon; Glucose Tolerance Test; Humans; Hypoglycemia; Insulinoma; Pancreatic Neoplasms; Professional Practice; Proinsulin

2013
Constant rate infusion of glucagon as an emergency treatment for hypoglycemia in a domestic ferret (Mustela putorius furo).
    Journal of the American Veterinary Medical Association, 2015, Feb-15, Volume: 246, Issue:4

    Topics: Animals; Blood Glucose; Female; Ferrets; Glucagon; Hypoglycemia; Insulinoma

2015
Colocalization of insulin and glucagon in insulinoma cells and developing pancreatic endocrine cells.
    Biochemical and biophysical research communications, 2015, Jun-12, Volume: 461, Issue:4

    Topics: Animals; Cell Line; Endocrine Cells; Glucagon; Insulin; Insulinoma; Mice; Pancreas; Pancreatic Neoplasms; Rats; Subcellular Fractions; Tissue Distribution

2015
A Northern contaminant mixture impairs pancreas function in obese and lean JCR rats and inhibits insulin secretion in MIN6 cells.
    Toxicology, 2015, Aug-06, Volume: 334

    Topics: Alcohol Drinking; Animals; Cell Death; Cell Line, Tumor; Complex Mixtures; Diabetes Mellitus; Disease Models, Animal; Dose-Response Relationship, Drug; Environmental Pollutants; Glucagon; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Male; Mice; Mitochondria; Obesity; Oxidative Stress; Pancreatic Neoplasms; Rats; Risk Assessment; Thinness

2015
Diagnostic Performance of 48-Hour Fasting Test and Insulin Surrogates in Patients With Suspected Insulinoma.
    Pancreas, 2017, Volume: 46, Issue:4

    Topics: 3-Hydroxybutyric Acid; Adult; Aged; Blood Glucose; C-Peptide; Fasting; Fatty Acids, Nonesterified; Female; Glucagon; Humans; Insulin; Insulinoma; Male; Middle Aged; Pancreatic Neoplasms; Retrospective Studies; Sensitivity and Specificity; Time Factors

2017
Alpha cell-specific Men1 ablation triggers the transdifferentiation of glucagon-expressing cells and insulinoma development.
    Gastroenterology, 2010, Volume: 138, Issue:5

    Topics: Age Factors; Aging; Animals; Biomarkers; Cell Fusion; Cell Lineage; Cell Proliferation; Cell Transdifferentiation; Cell Transformation, Neoplastic; Gene Deletion; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genotype; Glucagon; Glucagon-Secreting Cells; Glucagonoma; Insulin; Insulin-Secreting Cells; Insulinoma; Mice; Mice, Knockout; Pancreatic Neoplasms; Phenotype; Proto-Oncogene Proteins; Transcription Factors

2010
Multiple endocrine neoplasia type 1 deletion in pancreatic alpha-cells leads to development of insulinomas in mice.
    Endocrinology, 2010, Volume: 151, Issue:8

    Topics: Animals; Cells, Cultured; Gene Deletion; Gene Knockdown Techniques; Glucagon; Glucagon-Secreting Cells; Insulinoma; Mice; Mice, Transgenic; Organ Specificity; Pancreatic Neoplasms; Proto-Oncogene Proteins

2010
Glucagon test in insulinoma: Is it useful?
    Journal of endocrinological investigation, 2012, Volume: 35, Issue:6

    Topics: Adult; Aged; Blood Glucose; Female; Glucagon; Hormones; Humans; Hyperinsulinism; Hypoglycemia; Insulin; Insulinoma; Male; Middle Aged; Pancreatic Neoplasms; Radioimmunoassay; Young Adult

2012
Critical role of Egr transcription factors in regulating insulin biosynthesis, blood glucose homeostasis, and islet size.
    Endocrinology, 2012, Volume: 153, Issue:7

    Topics: Animals; Blood Glucose; Early Growth Response Transcription Factors; Gene Transfer Techniques; Glucagon; Glucose; Glucose Tolerance Test; Homeodomain Proteins; Homeostasis; Insulin; Insulin-Secreting Cells; Insulinoma; Islets of Langerhans; Mice; Mice, Transgenic; Mutation; Rats; Somatostatin; Transforming Growth Factor beta; Transgenes

2012
Asymptomatic insulinoma: a case report and autopsy series.
    Diabetes research and clinical practice, 2012, Volume: 98, Issue:3

    Topics: Autopsy; Calcium Gluconate; Diagnosis, Differential; Early Detection of Cancer; Female; Glucagon; Glucagonoma; Humans; Hypoglycemia; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Middle Aged; Pancreas; Pancreatic Neoplasms; Retrospective Studies; Tomography, X-Ray Computed

2012
Glucose dependence of insulinotropic actions of pituitary adenylate cyclase-activating polypeptide in insulin-secreting INS-1 cells.
    Pflugers Archiv : European journal of physiology, 2002, Volume: 444, Issue:4

    Topics: Action Potentials; Animals; Calcium; Calcium Channels; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Electrophysiology; Exocytosis; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Neuropeptides; Neurotransmitter Agents; Pancreatic Neoplasms; Patch-Clamp Techniques; Peptide Fragments; Pituitary Adenylate Cyclase-Activating Polypeptide; Protein Precursors; Rats; Tumor Cells, Cultured

2002
Transfection of pancreatic-derived beta-cells with a minigene encoding for human glucagon-like peptide-1 regulates glucose-dependent insulin synthesis and secretion.
    Endocrinology, 2002, Volume: 143, Issue:9

    Topics: Animals; Blotting, Northern; Blotting, Western; Cyclic AMP; Cytomegalovirus; Fluorescent Antibody Technique; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Mice; Microscopy, Fluorescence; Pancreatic Neoplasms; Peptide Fragments; Proglucagon; Promoter Regions, Genetic; Protein Precursors; RNA, Messenger; Signal Transduction; Transfection; Tumor Cells, Cultured

2002
Somatostatin inhibits glucagon-like peptide-1-induced insulin secretion and proliferation of RINm5F insulinoma cells.
    Regulatory peptides, 2002, Oct-15, Volume: 108, Issue:2-3

    Topics: Animals; Cell Division; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Drug Interactions; Glucagon; Glucagon-Like Peptide 1; Insulin; Insulin Secretion; Insulinoma; Pancreatic Neoplasms; Peptide Fragments; Protein Precursors; Rats; Somatostatin; Transcription Factors; Tumor Cells, Cultured

2002
Glucagon-like peptide-1 inhibits apoptosis of insulin-secreting cells via a cyclic 5'-adenosine monophosphate-dependent protein kinase A- and a phosphatidylinositol 3-kinase-dependent pathway.
    Endocrinology, 2003, Volume: 144, Issue:4

    Topics: Animals; Apoptosis; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; DNA; Glucagon; Glucagon-Like Peptide 1; Hydrogen Peroxide; Insulinoma; Islets of Langerhans; Mice; Oxidants; Peptide Fragments; Phosphatidylinositol 3-Kinases; Poly(ADP-ribose) Polymerases; Protein Precursors; Signal Transduction; Tumor Cells, Cultured

2003
[Hypoglycemia caused by beta-cell adenoma of the pancreas. Use of glucagon].
    Tijdschrift voor gastro-enterologie, 1963, Volume: 6

    Topics: Adenoma, Islet Cell; Glucagon; Humans; Hypoglycemia; Insulinoma; Pancreas; Pancreatic Diseases; Pancreatic Neoplasms

1963
METASTASIZING INSULINOMA TREATED WITH GLUCAGON.
    Danish medical bulletin, 1964, Volume: 11

    Topics: Adenoma, Islet Cell; Glucagon; Glucose; Humans; Hyperinsulinism; Insulin Coma; Insulinoma; Neoplasm Metastasis; Neoplasms; Pancreatic Neoplasms

1964
Glucagon and tolbutamide tests in the recognition of insulinomas.
    Proceedings of the Royal Society of Medicine, 1961, Volume: 54

    Topics: Adenoma, Islet Cell; Blood Glucose; Glucagon; Humans; Insulinoma; Pancreatic Neoplasms; Tolbutamide

1961
Amylin in pancreatic islets and pancreatic endocrine neoplasms.
    Pathology international, 2003, Volume: 53, Issue:9

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amyloid; Biomarkers, Tumor; Female; Glucagon; Glucagonoma; Humans; Immunoenzyme Techniques; Insulin; Insulinoma; Islet Amyloid Polypeptide; Islets of Langerhans; Male; Middle Aged; Pancreatic Neoplasms; Pancreatic Polypeptide; Somatostatin

2003
Expression in murine teratocarcinoma F9 cells of transcription factors involved in pancreas development.
    Transplantation proceedings, 2004, Volume: 36, Issue:4

    Topics: Animals; Cell Line; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Glucagon; Glucose; Homeobox Protein Nkx-2.2; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Mice; Pancreatic Neoplasms; Pancreatic Polypeptide; Reverse Transcriptase Polymerase Chain Reaction; Somatostatin; Transcription, Genetic

2004
Engineered beta-cells secreting dipeptidyl peptidase IV-resistant glucagon-like peptide-1 show enhanced glucose-responsiveness.
    Life sciences, 2005, Jan-28, Volume: 76, Issue:11

    Topics: Animals; Cell Line, Tumor; Clone Cells; Cricetinae; Cricetulus; Cyclic AMP; Dipeptidyl Peptidase 4; Genetic Engineering; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose; Humans; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Peptide Fragments; Protein Precursors; Rabbits; Rats; Receptors, Glucagon; Transfection

2005
Hypoglycemia in response to glucose and glucagon in insulinoma patients with a negative prolonged fast: functional and morphological properties.
    Journal of endocrinological investigation, 2004, Volume: 27, Issue:9

    Topics: Aged; Aged, 80 and over; Calcium; Fasting; Female; Glucagon; Glucose; Glucose Tolerance Test; Hepatic Veins; Humans; Hypoglycemia; Hypoglycemic Agents; Injections, Intra-Arterial; Injections, Intravenous; Insulin; Insulin Secretion; Insulinoma; Male; Pancreatic Neoplasms; Time Factors

2004
Glucagon production of the rat insulinoma cell line INS-1-A quantitative comparison with primary rat pancreatic islets.
    Biochemical and biophysical research communications, 2005, Apr-29, Volume: 330, Issue:1

    Topics: Animals; Cell Line, Tumor; Glucagon; Insulinoma; Islets of Langerhans; Palmitic Acid; Radioimmunoassay; Rats; RNA, Messenger

2005
Glucagon-like peptide-1 stimulates human insulin promoter activity in part through cAMP-responsive elements that lie upstream and downstream of the transcription start site.
    The Journal of endocrinology, 2005, Volume: 186, Issue:2

    Topics: Animals; Cell Line, Tumor; Cyclic AMP; Electrophoretic Mobility Shift Assay; Gene Expression; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Insulinoma; Peptide Fragments; Promoter Regions, Genetic; Protein Precursors; Rats; Response Elements; Transcription Initiation Site; Transfection

2005
Noninsulinoma pancreatogenous hypoglycemia syndrome: a rare case of adult-onset nesidioblastosis.
    Internal medicine (Tokyo, Japan), 2005, Volume: 44, Issue:8

    Topics: Age of Onset; Aged; Calcium Gluconate; Glucagon; Humans; Hypoglycemia; Insulin; Insulinoma; Male; Nesidioblastosis; Pancreatic Neoplasms; Somatostatin; Syndrome

2005
Metastatic insulinoma and glucagonoma from the pancreas responsible for specific peritumoral patterns of hepatic steatosis secondary to local effects of insulin and glucagon on hepatocytes.
    Gastroenterology, 2005, Volume: 129, Issue:4

    Topics: Adult; Fatty Liver; Female; Glucagon; Glucagonoma; Hepatocytes; Humans; Insulin; Insulin Secretion; Insulinoma; Liver; Liver Neoplasms; Pancreatic Neoplasms; Radiography

2005
Establishment of glucagon-producing cells by cell hybridization.
    Diabetes, 1984, Volume: 33, Issue:9

    Topics: Adenoma, Islet Cell; Animals; Cell Fusion; Cell Line; Cricetinae; Glucagon; Glucose; Histocytochemistry; Hybrid Cells; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Mesocricetus; Microscopy, Phase-Contrast; Neoplasm Transplantation; Theophylline

1984
[Tumors of the endocrine pancreas].
    Zentralblatt fur Chirurgie, 1984, Volume: 109, Issue:23

    Topics: Adenoma, Islet Cell; Adolescent; Adult; Aged; Child; Female; Follow-Up Studies; Gastrectomy; Gastrins; Glucagon; Humans; Hyperplasia; Insulin; Insulinoma; Islets of Langerhans; Male; Middle Aged; Pancreatectomy; Pancreatic Neoplasms; Postoperative Complications; Stomach Neoplasms; Zollinger-Ellison Syndrome

1984
Insulin secretion by a transplantable rat islet cell tumour.
    Diabetologia, 1981, Volume: 21, Issue:3

    Topics: Adenoma, Islet Cell; Animals; Colchicine; Epinephrine; Glucagon; Glucose; Insulin; Insulin Secretion; Insulinoma; Kinetics; Neoplasms, Experimental; Pancreatic Neoplasms; Rats; Rats, Inbred Strains; Somatostatin; Theophylline; Trifluoperazine; Vinblastine

1981
[The APUD concept and its clinical significance. 1].
    Fortschritte der Medizin, 1982, May-27, Volume: 100, Issue:20

    Topics: APUD Cells; Apudoma; Gastric Inhibitory Polypeptide; Gastrins; Glucagon; Glucagon-Like Peptides; Humans; Insulin; Insulinoma; Motilin; Pancreatic Neoplasms; Secretin

1982
Immunochemical identification of endocrine cell types in the streptozotocin nicotinamide-induced rat islet adenoma.
    Experimental and molecular pathology, 1982, Volume: 37, Issue:2

    Topics: Adenoma, Islet Cell; Animals; Glucagon; Histocytochemistry; Immunochemistry; Insulin; Insulinoma; Niacinamide; Pancreatic Neoplasms; Radioimmunoassay; Rats; Rats, Inbred Strains; Somatostatin; Streptozocin

1982
Fuel-induced insulin release in vitro from insulinomas transplanted into the rat kidney.
    Diabetes, 1984, Volume: 33, Issue:1

    Topics: Adenoma, Islet Cell; Animals; Cytochalasin B; Diazoxide; Glucagon; Glucose; Glyceraldehyde; Humans; In Vitro Techniques; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Keto Acids; Kidney; Male; Neoplasm Transplantation; Pancreatic Neoplasms; Radioimmunoassay; Rats; Somatostatin

1984
Immunohistochemical study of an insulinoma.
    Zentralblatt fur allgemeine Pathologie u. pathologische Anatomie, 1983, Volume: 128, Issue:3-4

    Topics: Adenoma, Islet Cell; Glucagon; Humans; Insulin; Insulinoma; Microscopy, Electron; Pancreatic Neoplasms; Somatostatin; Vasoactive Intestinal Peptide

1983
Pharmacological modifications of insulin release in vitro from fuel-responsive transplantable insulinomas.
    Endocrinology, 1984, Volume: 115, Issue:4

    Topics: Acetylcholine; Adenoma, Islet Cell; Animals; Blood Glucose; Glucagon; Glucose; Insulin; Insulinoma; Isoproterenol; Kidney; Neoplasm Transplantation; Organ Size; Pancreatic Neoplasms; Perfusion; Rats; Rats, Inbred Strains; Somatostatin; Tolbutamide

1984
L-leucine methyl ester stimulates insulin secretion and islet glutamate dehydrogenase.
    The American journal of physiology, 1983, Volume: 245, Issue:4

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line; Glucagon; Glucose; Glutamate Dehydrogenase; Glutamine; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Kinetics; Leucine; Male; Mice; Mice, Inbred Strains; Norepinephrine; Pancreatic Neoplasms; Rats

1983
Lack of suppression of insulin secretion by exercise in patients with insulinoma.
    Clinical endocrinology, 1981, Volume: 15, Issue:4

    Topics: Adenoma, Islet Cell; Adult; Aged; Blood Glucose; Female; Glucagon; Humans; Insulin; Insulin Secretion; Insulinoma; Pancreatic Neoplasms; Physical Exertion

1981
[The insulinoma case diagnosed by the use of glucagon test (author's transl)].
    Przeglad lekarski, 1981, Volume: 38, Issue:10

    Topics: Adenoma, Islet Cell; Adult; Blood Glucose; Female; Glucagon; Humans; Insulin; Insulinoma; Pancreatic Neoplasms

1981
Plasma insulin response to various secretagogues in insulinoma.
    The Tohoku journal of experimental medicine, 1982, Volume: 136, Issue:4

    Topics: Adenoma, Islet Cell; Adult; Aged; Arginine; Blood Glucose; Child; Fasting; Female; Glucagon; Glucose Tolerance Test; Humans; Insulin; Insulinoma; Male; Middle Aged; Pancreatic Neoplasms; Radioimmunoassay; Tolbutamide

1982
Validation of a rapid solid-phase radioimmunoassay for canine, bovine, and equine insulin.
    American journal of veterinary research, 1982, Volume: 43, Issue:7

    Topics: Adenoma, Islet Cell; Animals; Carcinoma; Cattle; Chromatography, Gel; Dog Diseases; Dogs; Female; Glucagon; Glucose; Horse Diseases; Horses; Hypoglycemia; Insulin; Insulinoma; Male; Pancreatic Neoplasms; Radioimmunoassay

1982
Insulin and C-peptide in plasma and tumor of insulinoma patients.
    The Tohoku journal of experimental medicine, 1983, Volume: 139, Issue:1

    Topics: Adenoma, Islet Cell; Adult; Aged; Blood Glucose; C-Peptide; Chromatography, Gel; Fasting; Female; Glucagon; Glucose Tolerance Test; Humans; Insulin; Insulinoma; Male; Middle Aged; Pancreatic Neoplasms; Peptides

1983
Evidence for a therapeutic effect of dl-propranolol in benign and malignant insulinoma: report of three cases.
    Journal of endocrinological investigation, 1983, Volume: 6, Issue:1

    Topics: Adenoma, Islet Cell; Aged; Blood Glucose; Female; Glucagon; Glucose Tolerance Test; Humans; Insulin; Insulinoma; Middle Aged; Pancreatic Neoplasms; Propranolol

1983
Diazoxide infusion test in patients with single benign insulinoma.
    Hormone research, 1983, Volume: 17, Issue:3

    Topics: Adenoma, Islet Cell; Adult; Aged; Blood Glucose; Diazoxide; Glucagon; Humans; Insulin; Insulinoma; Kinetics; Middle Aged; Pancreatic Neoplasms

1983
[Therapy of hypoglycemia in the adult].
    Deutsche medizinische Wochenschrift (1946), 1983, Jul-08, Volume: 108, Issue:27

    Topics: Adenoma, Islet Cell; Adult; Diazoxide; Glucagon; Glucose; Humans; Hypoglycemia; Injections, Intravenous; Insulinoma; Patient Education as Topic; Phenytoin

1983
Functional and morphologic characterization of human insulinomas.
    Diabetes, 1983, Volume: 32, Issue:10

    Topics: Adenoma, Islet Cell; Adolescent; Adult; Aged; Female; Fluorescent Antibody Technique; Glucagon; Growth Hormone; Humans; Insulin; Insulin Secretion; Insulinoma; Male; Microscopy, Electron; Middle Aged; Pancreatic Function Tests; Pancreatic Neoplasms; Pancreatic Polypeptide; Proinsulin; Radioimmunoassay

1983
Thiol-protein disulfide oxidoreductase and peptidase activities in insulinoma tissue.
    Biomedica biochimica acta, 1983, Volume: 42, Issue:9

    Topics: Adenoma, Islet Cell; Adult; Biotransformation; Chromatography, Gel; Glucagon; Humans; Hydrogen-Ion Concentration; Insulin; Insulinoma; Kinetics; Male; Oxidoreductases; Pancreatic Neoplasms; Peptide Hydrolases; Protein Disulfide Reductase (Glutathione); Radioimmunoassay

1983
Secretory granules in benign and malignant glucagonomas of the pancreas.
    Acta pathologica japonica, 1984, Volume: 34, Issue:1

    Topics: Adenoma, Islet Cell; Adult; C-Peptide; Cytoplasmic Granules; Glucagon; Glucagonoma; Humans; Insulinoma; Male; Neoplasm Metastasis; Neoplasms, Multiple Primary; Pancreatic Neoplasms; Radioimmunoassay

1984
Analysis of insulin secretion based on changes in plasma insulin and C-peptide in man.
    The Tohoku journal of experimental medicine, 1982, Volume: 138, Issue:4

    Topics: Adult; Aged; Arginine; C-Peptide; Diabetes Mellitus; Female; Glucagon; Glucose Tolerance Test; Humans; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Liver Cirrhosis; Male; Middle Aged; Nephritis; Pancreatic Neoplasms; Peptides; Tolbutamide

1982
Signal transduction of the GLP-1-receptor cloned from a human insulinoma.
    FEBS letters, 1994, Jul-04, Volume: 348, Issue:1

    Topics: Amino Acid Sequence; Animals; Blotting, Northern; Calcium; Cell Line; Cloning, Molecular; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Insulinoma; Molecular Sequence Data; Peptide Fragments; Rats; Receptors, Glucagon; Recombinant Proteins; RNA; Sequence Homology, Amino Acid; Signal Transduction; Transfection

1994
Activation of a cAMP-regulated Ca(2+)-signaling pathway in pancreatic beta-cells by the insulinotropic hormone glucagon-like peptide-1.
    The Journal of biological chemistry, 1995, Jul-28, Volume: 270, Issue:30

    Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Calcium; Cell Line; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Insulinoma; Ion Channels; Islets of Langerhans; Membrane Potentials; Peptide Fragments; Protein Precursors; Rats; Signal Transduction; Tumor Cells, Cultured

1995
Glucagon-like peptide-1 affects gene transcription and messenger ribonucleic acid stability of components of the insulin secretory system in RIN 1046-38 cells.
    Endocrinology, 1995, Volume: 136, Issue:11

    Topics: Animals; Culture Media, Conditioned; Cycloheximide; Dactinomycin; Drug Stability; Drug Synergism; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Glucose; Glucose Transporter Type 1; Hexokinase; Insulin; Insulin Secretion; Insulinoma; Monosaccharide Transport Proteins; Pancreatic Neoplasms; Peptide Fragments; Protein Precursors; Rats; RNA, Messenger; Transcription, Genetic; Tumor Cells, Cultured

1995
Molecular cloning, functional expression, and signal transduction of the GIP-receptor cloned from a human insulinoma.
    FEBS letters, 1995, Oct-02, Volume: 373, Issue:1

    Topics: Amino Acid Sequence; Animals; Base Sequence; Binding, Competitive; Clone Cells; Cricetinae; Gastric Inhibitory Polypeptide; Gene Library; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Insulinoma; Kinetics; Molecular Sequence Data; Pancreatic Neoplasms; Peptide Fragments; Protein Precursors; Rats; Receptors, Gastrointestinal Hormone; Receptors, Glucagon; Recombinant Proteins; Sequence Homology, Amino Acid; Signal Transduction; Substrate Specificity; Swine; Transfection; Tumor Cells, Cultured

1995
Surgical removal of insulinoma restores glucose recovery from hypoglycaemia but does not normalize insulin action.
    European journal of clinical investigation, 1995, Volume: 25, Issue:5

    Topics: Adult; Blood Glucose; Female; Glucagon; Growth Hormone; Homeostasis; Humans; Hypoglycemia; Insulin; Insulinoma; Male; Middle Aged; Pancreatic Neoplasms

1995
Amylin alters the biological action of the incretin hormone GLP-1(7-36)amide.
    Life sciences, 1993, Volume: 53, Issue:17

    Topics: Adenylyl Cyclases; Amyloid; Animals; Cell Line; Colforsin; Cyclic AMP; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose Intolerance; Insulinoma; Islet Amyloid Polypeptide; Islets of Langerhans; Models, Biological; Peptide Fragments; Peptides; Rats; Substance P

1993
Glucagon-like peptide I increases cytoplasmic calcium in insulin-secreting beta TC3-cells by enhancement of intracellular calcium mobilization.
    Diabetes, 1995, Volume: 44, Issue:7

    Topics: Animals; Calcium; Calcium Channels; Cell Line; Colforsin; Cyclic AMP; Cytoplasm; Dose-Response Relationship, Drug; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Inositol Phosphates; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Kinetics; Mice; Mice, Transgenic; Pancreatic Neoplasms; Peptide Fragments; Ryanodine; Time Factors; Tumor Cells, Cultured

1995
The glucagon gene is transcribed in beta-like pancreatic cells.
    Experimental cell research, 1995, Volume: 218, Issue:2

    Topics: Animals; Base Sequence; Binding Sites; Cell Line, Transformed; Glucagon; Glucagonoma; Humans; Insulinoma; Islets of Langerhans; Molecular Sequence Data; Polymerase Chain Reaction; Rats; Sequence Alignment; Transcription, Genetic

1995
Expression of insulin receptor on clonal pancreatic alpha cells and its possible role for insulin-stimulated negative regulation of glucagon secretion.
    Diabetologia, 1995, Volume: 38, Issue:4

    Topics: Animals; Base Sequence; Blotting, Northern; Clone Cells; Cricetinae; DNA Primers; Gene Expression; Glucagon; Humans; Immunohistochemistry; Insulin; Insulinoma; Kinetics; Methionine; Molecular Sequence Data; Pancreatic Neoplasms; Polymerase Chain Reaction; Receptor, Insulin; RNA, Messenger; Sulfur Radioisotopes; Tumor Cells, Cultured

1995
A novel insulin secretagogue is a phosphodiesterase inhibitor.
    Diabetes, 1995, Volume: 44, Issue:1

    Topics: Animals; Calcium; Cells, Cultured; Cyclic AMP; Dose-Response Relationship, Drug; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Mice; Mice, Inbred C57BL; Mice, Obese; Pancreatic Neoplasms; Peptide Fragments; Phosphodiesterase Inhibitors; Piperazines; Protein Precursors; Tumor Cells, Cultured

1995
Glucagon-like peptide-1 (GLP-1) molecular forms in human pancreatic endocrine tumors resemble those in intestine rather than pancreas.
    Diabetes research and clinical practice, 1994, Volume: 25, Issue:1

    Topics: Chromatography, High Pressure Liquid; Glucagon; Glucagon-Like Peptide 1; Glucagonoma; Humans; Insulinoma; Pancreatic Neoplasms; Peptide Fragments; Protein Precursors; Radioimmunoassay; Reference Values

1994
The role of prohormone convertases PC1 (PC3) and PC2 in the cell-specific processing of proglucagon.
    Biochemical and biophysical research communications, 1995, Feb-15, Volume: 207, Issue:2

    Topics: Animals; Aspartic Acid Endopeptidases; Base Sequence; Blotting, Northern; Cell Line; Chromatography, High Pressure Liquid; DNA Primers; Glucagon; Glucagon-Like Peptides; Insulinoma; Molecular Sequence Data; Oxyntomodulin; Pancreatic Neoplasms; Peptide Fragments; Pituitary Neoplasms; Polymerase Chain Reaction; Proglucagon; Proprotein Convertase 2; Proprotein Convertases; Protein Precursors; Protein Processing, Post-Translational; Rats; RNA, Messenger; Subtilisins; Transfection

1995
Structure/activity characterization of glucagon-like peptide-1.
    European journal of biochemistry, 1994, Nov-01, Volume: 225, Issue:3

    Topics: Amino Acid Sequence; Animals; Binding Sites; Binding, Competitive; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Insulinoma; Kinetics; Molecular Sequence Data; Pancreatic Neoplasms; Peptide Fragments; Protein Precursors; Rats; Receptors, Cell Surface; Receptors, Glucagon; Structure-Activity Relationship; Tumor Cells, Cultured

1994
Ras antagonizes cAMP stimulated glucagon gene transcription in pancreatic islet cell lines.
    FEBS letters, 1994, Oct-24, Volume: 353, Issue:3

    Topics: Adenoma, Islet Cell; Animals; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Genes, Dominant; Genes, ras; Glucagon; Glucagonoma; Insulinoma; Mutation; Promoter Regions, Genetic; Protein Kinase C; ras Proteins; Rats; Recombinant Fusion Proteins; RNA, Messenger; Signal Transduction; Transcription, Genetic; Transfection; Tumor Cells, Cultured

1994
Incretin hormones regulate glucose-dependent insulin secretion in RIN 1046-38 cells: mechanisms of action.
    Endocrinology, 1994, Volume: 135, Issue:2

    Topics: Animals; Calcium; Dose-Response Relationship, Drug; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Insulin Secretion; Insulinoma; Kinetics; Membrane Potentials; Pancreatic Neoplasms; Peptide Fragments; Potassium Chloride; Protein Precursors; Rats; Signal Transduction; Tumor Cells, Cultured

1994
[Benign insulinoma. Efficacy of preoperative treatment for persistent hyperinsulinemia using a synthetic somatostatin analog].
    Minerva endocrinologica, 1994, Volume: 19, Issue:1

    Topics: Aged; Blood Glucose; C-Peptide; Combined Modality Therapy; Female; Glucagon; Humans; Insulin; Insulinoma; Octreotide; Pancreatic Neoplasms

1994
Chromostatin, a chromogranin A-derived bioactive peptide, is present in human pancreatic insulin (beta) cells.
    Proceedings of the National Academy of Sciences of the United States of America, 1993, Mar-15, Volume: 90, Issue:6

    Topics: Adrenal Medulla; Chromogranin A; Chromogranins; Diabetes Mellitus, Type 1; Glucagon; Humans; Immune Sera; Immunohistochemistry; Insulin; Insulinoma; Islets of Langerhans; Microscopy, Immunoelectron; Pancreas; Pancreatic Neoplasms; Pancreatic Polypeptide; Peptide Fragments; Somatostatin

1993
Multiple endocrine neoplasm, type 1. Gastrinomas, pancreatic neoplasms, microcarcinoids, the Zollinger-Ellison syndrome, lymph nodes, and hepatic metastases.
    Archives of surgery (Chicago, Ill. : 1960), 1993, Volume: 128, Issue:10

    Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Female; Follow-Up Studies; Gastrinoma; Gastrins; Glucagon; Humans; Insulin; Insulinoma; Liver Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Multiple Endocrine Neoplasia; Pancreatic Neoplasms; Prospective Studies; Retrospective Studies; Zollinger-Ellison Syndrome

1993
Detection of the human glucagon-like peptide 1(7-36) amide receptor on insulinoma-derived cell membranes.
    Digestion, 1994, Volume: 55, Issue:1

    Topics: Animals; Cell Membrane; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Humans; Insulinoma; Islets of Langerhans; Pancreatic Neoplasms; Peptide Fragments; Rats; Receptors, Cell Surface; Receptors, Glucagon; Tumor Cells, Cultured

1994
Structure-activity relationships of glucagon-like peptide-1(7-36)amide: insulinotropic activities in perfused rat pancreases, and receptor binding and cyclic AMP production in RINm5F cells.
    The Journal of endocrinology, 1994, Volume: 140, Issue:1

    Topics: Animals; Cell Line; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Insulin; Insulinoma; Male; Pancreas; Peptide Fragments; Perfusion; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, Glucagon; Stimulation, Chemical; Structure-Activity Relationship

1994
Sulfonylurea-binding sites and ATP-sensitive K+ channels in alpha-TC glucagonoma and beta-TC insulinoma cells.
    Diabetes, 1993, Volume: 42, Issue:12

    Topics: Adenosine Triphosphate; Animals; Binding Sites; Binding, Competitive; Diazoxide; Glucagon; Glucagonoma; Glyburide; Insulinoma; Kinetics; Membrane Potentials; Mice; Pancreatic Neoplasms; Potassium Channels; Tolbutamide; Tritium; Tumor Cells, Cultured

1993
Insulin surrogates in insulinoma.
    The Journal of clinical endocrinology and metabolism, 1993, Volume: 77, Issue:2

    Topics: 3-Hydroxybutyric Acid; Adolescent; Adult; Aged; Blood Glucose; C-Peptide; Fasting; Fatty Acids, Nonesterified; Female; Glucagon; Humans; Hydroxybutyrates; Insulin; Insulinoma; Male; Middle Aged; Pancreatic Neoplasms

1993
Amino-terminal parathyroid hormone-related protein: specific binding and cytosolic calcium responses in rat insulinoma cells.
    Endocrinology, 1993, Volume: 132, Issue:3

    Topics: Animals; Binding Sites; Calcium; Cell Membrane; Cyclic AMP; Cytosol; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glyburide; Insulinoma; Kinetics; Pancreatic Neoplasms; Parathyroid Hormone; Parathyroid Hormone-Related Protein; Peptide Fragments; Peptides; Proteins; Rats; Rats, Inbred WF; Tumor Cells, Cultured

1993
Neuropeptide Y expression and regulation in a differentiated rat insulin-secreting cell line.
    Endocrinology, 1993, Volume: 133, Issue:3

    Topics: Adenylyl Cyclases; Animals; Cell Differentiation; Clonidine; Colforsin; Cyclic AMP; Enzyme Activation; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation, Neoplastic; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Insulin; Insulin Secretion; Insulinoma; Neuropeptide Y; Pancreatic Neoplasms; Peptide Fragments; Protein Kinase C; Rats; Receptors, Neuropeptide Y; Tumor Cells, Cultured

1993
Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulin-secreting beta-cells.
    The Journal of biological chemistry, 1993, Sep-15, Volume: 268, Issue:26

    Topics: Animals; Binding, Competitive; Cell Line; Cell Membrane; Cyclic AMP; Exenatide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Insulin; Insulin Secretion; Insulinoma; Kinetics; Lizards; Lung; Pancreatic Neoplasms; Peptide Fragments; Peptides; Rats; Receptors, Cell Surface; Receptors, Glucagon; Tumor Cells, Cultured; Venoms

1993
Abnormal facilitative glucose transporter gene expression in human islet cell tumors.
    The Journal of clinical endocrinology and metabolism, 1993, Volume: 76, Issue:1

    Topics: Base Sequence; Female; Gastrinoma; Gastrins; Gene Expression; Gene Expression Regulation, Neoplastic; Glucagon; Glucagonoma; Humans; Insulin; Insulinoma; Male; Middle Aged; Molecular Sequence Data; Monosaccharide Transport Proteins; Oligodeoxyribonucleotides; Pancreatic Neoplasms; Polymerase Chain Reaction; RNA, Messenger

1993
The Gly40Ser mutation in the human glucagon receptor gene associated with NIDDM results in a receptor with reduced sensitivity to glucagon.
    Diabetes, 1996, Volume: 45, Issue:6

    Topics: Amino Acid Sequence; Animals; Cell Line; Cricetinae; Cyclic AMP; Diabetes Mellitus, Type 2; Exons; Glucagon; Glycine; Humans; Insulin; Insulin Secretion; Insulinoma; Kidney; Kinetics; Molecular Sequence Data; Pancreatic Neoplasms; Point Mutation; Protein Structure, Secondary; Rats; Receptors, Glucagon; Recombinant Proteins; Serine; Transfection

1996
Desensitization of glucagon-like peptide 1 receptors in insulin-secreting beta TC3 cells: role of PKA-independent mechanisms.
    British journal of pharmacology, 1996, Volume: 118, Issue:3

    Topics: Animals; Calcium; Glucagon; Glucose; Insulinoma; Mice; Mice, Inbred Strains; Protein Kinase C; Receptors, Glucagon; Time Factors; Tumor Cells, Cultured

1996
GLP-1/GIP chimeric peptides define the structural requirements for specific ligand-receptor interaction of GLP-1.
    Regulatory peptides, 1996, May-07, Volume: 63, Issue:1

    Topics: Amino Acid Sequence; Animals; Chloramines; Cyclic AMP; Dose-Response Relationship, Drug; Gastric Inhibitory Polypeptide; Gastrointestinal Agents; Glucagon; Glucagon-Like Peptide 1; Indicators and Reagents; Insulinoma; Iodine Radioisotopes; Molecular Sequence Data; Peptide Fragments; Protein Precursors; Radioligand Assay; Rats; Recombinant Fusion Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Structure-Activity Relationship; Tosyl Compounds; Tumor Cells, Cultured

1996
Glucagon acts through its own receptors in the presence of functional glucagon-like peptide-1 receptors on hamster insulinoma.
    Endocrinology, 1996, Volume: 137, Issue:10

    Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Cell Line; Cell Membrane; Cricetinae; Cross-Linking Reagents; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Insulinoma; Islets of Langerhans; Mice; Pancreatic Neoplasms; Peptide Fragments; Peptides; Receptors, Glucagon; RNA, Messenger

1996
Signal transduction and desensitization of the glucagon-like peptide-1 receptor.
    Acta physiologica Scandinavica, 1996, Volume: 157, Issue:3

    Topics: Animals; Cyclic AMP; Gene Deletion; Glucagon; Glucagon-Like Peptide 1; Humans; Insulinoma; Mutation; Peptide Fragments; Phosphorylation; Protein Precursors; Receptors, Glucagon; Sensitivity and Specificity; Signal Transduction; Tumor Cells, Cultured

1996
The signal transduction of the glucagon-like peptide 1 receptor: fishing beyond the protein kinase level.
    Acta physiologica Scandinavica, 1996, Volume: 157, Issue:3

    Topics: Colforsin; Electrophoresis, Gel, Two-Dimensional; Glucagon; Glucagon-Like Peptide 1; Insulinoma; Isoelectric Focusing; Molecular Weight; Peptide Fragments; Phosphoproteins; Phosphorylation; Protein Kinases; Protein Precursors; Receptors, Glucagon; Signal Transduction; Tumor Cells, Cultured

1996
Glucagon-like peptide-1(7-36)amide and cytoplasmic calcium in insulin producing cells.
    Acta physiologica Scandinavica, 1996, Volume: 157, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Cytoplasm; Fura-2; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Insulin; Insulinoma; Islets of Langerhans; Male; Neurotransmitter Agents; Peptide Fragments; Phosphodiesterase Inhibitors; Protein Precursors; Rats; Rats, Sprague-Dawley; Sincalide; Tumor Cells, Cultured

1996
Desensitization and phosphorylation of the glucagon-like peptide-1 (GLP-1) receptor by GLP-1 and 4-phorbol 12-myristate 13-acetate.
    Molecular endocrinology (Baltimore, Md.), 1996, Volume: 10, Issue:1

    Topics: Amino Acid Sequence; Animals; Blotting, Western; Cyclic AMP; Enzyme Activation; Enzyme Inhibitors; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Indoles; Insulinoma; Molecular Sequence Data; Pancreatic Neoplasms; Peptide Fragments; Phosphorylation; Protein Kinase C; Protein Precursors; Rats; Receptors, Glucagon; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured

1996
Effects of glucagon-like peptide-1 (GLP-1) in RINm5F insulinoma cells. Stimulation of insulin secretion, insulin content, and insulin receptor binding.
    Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 1995, Volume: 103 Suppl 2

    Topics: Animals; Glucagon; Glucagon-Like Peptide 1; Insulin; Insulinoma; Iodine Radioisotopes; Microscopy, Electron; Pancreatic Neoplasms; Peptide Fragments; Protein Precursors; Rats; Receptor, Insulin; Tumor Cells, Cultured

1995
Ligand-induced regulation of glucagon-like peptide-I receptor function and expression in insulin-secreting beta cells.
    Pancreas, 1996, Volume: 13, Issue:3

    Topics: Animals; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Enzyme Activation; Gene Expression; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Guanosine 5'-O-(3-Thiotriphosphate); Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Pancreatic Neoplasms; Peptide Fragments; Protein Precursors; Protein Synthesis Inhibitors; Rats; Receptors, Glucagon; RNA, Messenger; Tumor Cells, Cultured

1996
Clinical spectrum of hyperglucagonemia associated with malignant neuroendocrine tumors.
    Mayo Clinic proceedings, 1996, Volume: 71, Issue:11

    Topics: Adult; Aged; Blood Glucose; Carcinoid Tumor; Diabetes Mellitus; Female; Glucagon; Glucagonoma; Hormones; Humans; Insulinoma; Male; Middle Aged; Multiple Endocrine Neoplasia; Neuroendocrine Tumors; Retrospective Studies; Zollinger-Ellison Syndrome

1996
FA1 immunoreactivity in endocrine tumours and during development of the human fetal pancreas; negative correlation with glucagon expression.
    Histochemistry and cell biology, 1996, Volume: 106, Issue:6

    Topics: Antibodies, Monoclonal; Endocrine Gland Neoplasms; Epidermal Growth Factor; Fetus; Fluorescent Antibody Technique; Glucagon; Glucagonoma; Glycoproteins; Humans; Insulin; Insulinoma; Neuroendocrine Tumors; Pancreas; Pheochromocytoma; Somatostatin; Tumor Cells, Cultured

1996
[Endocrine function of the pancreas in patients with organic hyperinsulinism syndrome].
    Klinichna khirurhiia, 1996, Issue:5

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Blood Glucose; C-Peptide; Female; Glucagon; Humans; Hyperinsulinism; Insulin; Insulinoma; Islets of Langerhans; Male; Middle Aged; Pancreatic Neoplasms; Radioimmunoassay

1996
Regulation of glycosylphosphatidylinositol-specific phospholipase D secretion from beta TC3 cells.
    Endocrinology, 1997, Volume: 138, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Carbachol; Cycloheximide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Immunohistochemistry; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Kinetics; Mice; Pancreatic Neoplasms; Peptide Fragments; Phospholipase D; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured

1997
Tissue-specific and glucose-dependent expression of receptor genes for glucagon and glucagon-like peptide-1 (GLP-1).
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1997, Volume: 29, Issue:2

    Topics: Animals; DNA, Complementary; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulinoma; Islets of Langerhans; Mice; Mice, Inbred C57BL; Peptides; Protein Biosynthesis; Protein Precursors; RNA, Messenger; Tissue Distribution; Tumor Cells, Cultured

1997
Chromogranin A plasma concentration and expression in pancreatic islet cell tumors of dogs and cats.
    American journal of veterinary research, 1997, Volume: 58, Issue:6

    Topics: Animals; Cat Diseases; Cats; Cattle; Chromogranin A; Chromogranins; Dog Diseases; Dogs; Gene Expression Regulation, Neoplastic; Glucagon; Immune Sera; Immunohistochemistry; Insulin; Insulinoma; Pancreas; Pancreatic Neoplasms; Pancreatic Polypeptide; Phosphopyruvate Hydratase; Radioimmunoassay; Somatostatin

1997
Endoproteolysis of glucagon-like peptide (GLP)-1 (7-36) amide by ectopeptidases in RINm5F cells.
    Peptides, 1997, Volume: 18, Issue:5

    Topics: Amino Acid Sequence; Animals; Cell Membrane; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Hydrolysis; Insulinoma; Peptide Fragments; Peptide Hydrolases; Rats; Tumor Cells, Cultured

1997
Cloning and characterization of the 5' flanking sequences (promoter region) of the human GLP-1 receptor gene.
    Peptides, 1997, Volume: 18, Issue:5

    Topics: Base Sequence; Cloning, Molecular; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Humans; Insulinoma; Molecular Sequence Data; Peptide Fragments; Promoter Regions, Genetic; Receptors, Glucagon; Sequence Analysis, DNA; Transcription, Genetic; Tumor Cells, Cultured

1997
Insulinoma associated with a case of multiple endocrine neoplasia type I: Functional somatostatin receptors and abnormal glucose-induced insulin secretion.
    Hormone research, 1997, Volume: 48, Issue:2

    Topics: Actins; Adolescent; Dose-Response Relationship, Drug; Follow-Up Studies; Gene Expression Regulation, Neoplastic; Glucagon; Glucose; Glucose Transporter Type 1; Hormones; Humans; Hyperparathyroidism; Immunohistochemistry; Injections, Intravenous; Insulin; Insulin Secretion; Insulinoma; Male; Monosaccharide Transport Proteins; Multiple Endocrine Neoplasia Type 1; Octreotide; Pancreatic Neoplasms; Parathyroid Neoplasms; Receptors, Somatostatin; RNA, Messenger; Tomography, Emission-Computed, Single-Photon

1997
Return of beta-adrenergic sensitivity in a patient with insulinoma after removal of the tumour.
    Diabetic medicine : a journal of the British Diabetic Association, 1997, Volume: 14, Issue:11

    Topics: Adrenergic beta-Agonists; Adult; Blood Glucose; Epinephrine; Glucagon; Human Growth Hormone; Humans; Hydrocortisone; Hypoglycemia; Insulinoma; Isoproterenol; Male; Pancreatic Neoplasms; Receptors, Adrenergic, beta

1997
[Features of anesthesia in surgical removal of insulinoma].
    Klinichna khirurhiia, 1997, Issue:9-10

    Topics: Anesthesia, General; Glucagon; Hemodynamics; Humans; Insulin; Insulinoma; Neuroleptanalgesia; Neuromuscular Nondepolarizing Agents; Pancreatic Neoplasms; Pipecuronium

1997
Effect of chronic central administration of glucagon-like peptide-1 (7-36) amide on food consumption and body weight in normal and obese rats.
    Obesity research, 1998, Volume: 6, Issue:2

    Topics: Animals; Body Weight; Eating; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Injections, Intraventricular; Insulinoma; Male; Neurotransmitter Agents; Obesity; Pancreatic Neoplasms; Peptide Fragments; Rats; Rats, Sprague-Dawley; Rats, Zucker; Receptors, Glucagon; Tumor Cells, Cultured

1998
The role of glucagon administration in the diagnosis and treatment of patients with tumor hypoglycemia.
    Cancer, 1998, Apr-15, Volume: 82, Issue:8

    Topics: Adult; Aged; Blood Glucose; Carcinoma; Carcinoma, Hepatocellular; Colonic Neoplasms; Female; Glucagon; Hemangiopericytoma; Humans; Hypoglycemia; Infusion Pumps; Insulinoma; Liver Neoplasms; Meningeal Neoplasms; Middle Aged; Pancreatic Neoplasms; Sarcoma

1998
Central infusion of glucagon-like peptide-1-(7-36) amide (GLP-1) receptor antagonist attenuates lithium chloride-induced c-Fos induction in rat brainstem.
    Brain research, 1998, Aug-10, Volume: 801, Issue:1-2

    Topics: Animals; Brain Stem; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Guinea Pigs; Infusions, Parenteral; Injections, Intraperitoneal; Injections, Intraventricular; Insulin; Insulin Secretion; Insulinoma; Lithium Chloride; Male; Neurons; Peptide Fragments; Proto-Oncogene Proteins c-fos; Rats; Rats, Long-Evans; Receptors, Glucagon; Signal Transduction; Tumor Cells, Cultured

1998
Contribution of a PS1-like element to the tissue- and cell-specific expression of the human GLP-1 receptor gene.
    FEBS letters, 1998, Oct-02, Volume: 436, Issue:2

    Topics: Animals; Base Sequence; Cell Line; Cell Nucleus; Cloning, Molecular; Cricetinae; Enhancer Elements, Genetic; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagonoma; Humans; Insulinoma; Islets of Langerhans; Molecular Sequence Data; Mutagenesis, Site-Directed; Organ Specificity; Pancreatic Neoplasms; Peptide Fragments; Promoter Regions, Genetic; Protein Precursors; Receptors, Glucagon; Recombinant Proteins; Sequence Deletion; Sequence Homology, Nucleic Acid; Simian virus 40; Transfection; Tumor Cells, Cultured

1998
Inhibition of glucose stimulated insulin secretion by neuropeptide Y is mediated via the Y1 receptor and inhibition of adenylyl cyclase in RIN 5AH rat insulinoma cells.
    Diabetologia, 1998, Volume: 41, Issue:12

    Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Blotting, Northern; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Insulin Secretion; Insulinoma; Iodine Radioisotopes; Isoproterenol; Neuropeptide Y; Pancreatic Neoplasms; Peptide Fragments; Peptide YY; Protein Precursors; Rats; Receptors, Neuropeptide Y; Swine; Tumor Cells, Cultured

1998
Evaluation of immunoisolated insulin-secreting beta TC6-F7 cells as a bioartificial pancreas.
    Annals of transplantation, 1997, Volume: 2, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Blood Glucose; Capsules; Cell Division; Cell Separation; Diabetes Mellitus, Experimental; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Insulin; Insulin Secretion; Insulinoma; Pancreas, Artificial; Pancreatic Neoplasms; Peptide Fragments; Protein Precursors; Rats; Rats, Wistar; Time Factors; Tumor Cells, Cultured

1997
Glucagon-like peptide-1 regulates the beta cell transcription factor, PDX-1, in insulinoma cells.
    Endocrinology, 1999, Volume: 140, Issue:10

    Topics: Animals; Glucagon; Glucagon-Like Peptide 1; Homeodomain Proteins; Insulinoma; Pancreatic Neoplasms; Peptide Fragments; Protein Precursors; Rats; RNA, Messenger; Trans-Activators; Tumor Cells, Cultured

1999
GLP-1-analogues resistant to degradation by dipeptidyl-peptidase IV in vitro.
    Regulatory peptides, 2000, Jan-29, Volume: 86, Issue:1-3

    Topics: Animals; Binding, Competitive; Chromatography, High Pressure Liquid; Cyclic AMP; Dipeptidyl Peptidase 4; Glucagon; Glucagon-Like Peptide 1; Insulinoma; Molecular Structure; Peptide Fragments; Protein Precursors; Rats; Receptors, G-Protein-Coupled; Receptors, Gastrointestinal Hormone; Tumor Cells, Cultured

2000
Abundant expression of 150-kDa oxygen-regulated protein in mouse pancreatic beta cells is correlated with insulin secretion.
    Biochemical and biophysical research communications, 2000, Jan-27, Volume: 267, Issue:3

    Topics: Animals; Eating; Fasting; Glucagon; Glucose; HSP70 Heat-Shock Proteins; Immunohistochemistry; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Male; Membrane Proteins; Mice; Molecular Chaperones; Organ Specificity; Oxygen; Pancreatic Neoplasms; Proteins; Somatostatin; Tumor Cells, Cultured

2000
Glucagon-like peptide-1 improves insulin and proinsulin binding on RINm5F cells and human monocytes.
    American journal of physiology. Endocrinology and metabolism, 2000, Volume: 279, Issue:1

    Topics: Adult; Animals; Exenatide; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Humans; Insulin; Insulinoma; Male; Monocytes; Pancreatic Neoplasms; Peptide Fragments; Peptides; Proinsulin; Protein Precursors; Rats; Receptors, Glucagon; Tumor Cells, Cultured; Venoms

2000
Regulation of the diabetes-associated autoantigen IA-2 in INS-1 pancreatic beta-cells.
    Diabetes, 2000, Volume: 49, Issue:7

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Autoantigens; Colforsin; Cyclic AMP; Gene Expression Regulation; Glucagon; Glucose; Insulinoma; Islets of Langerhans; Kinetics; Membrane Proteins; Pancreatic Neoplasms; Protein Kinase C; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Rats; Receptor-Like Protein Tyrosine Phosphatases, Class 8; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Somatostatin; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured

2000
Glucagon-like peptide 1 stimulates insulin gene promoter activity by protein kinase A-independent activation of the rat insulin I gene cAMP response element.
    Diabetes, 2000, Volume: 49, Issue:7

    Topics: Animals; Base Sequence; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Insulin; Insulinoma; Luciferases; Pancreatic Neoplasms; Peptide Fragments; Promoter Regions, Genetic; Protein Precursors; Rats; Recombinant Fusion Proteins; Second Messenger Systems; Sequence Deletion; Transcription, Genetic; Tumor Cells, Cultured; Venoms

2000
Ca2+ and electrolyte mobilization following agonist application to the pancreatic beta cell line HIT.
    Pflugers Archiv : European journal of physiology, 2000, Volume: 440, Issue:6

    Topics: Animals; Calcium; Cytoplasm; Cytoplasmic Granules; Electrolytes; Electron Probe Microanalysis; Extracellular Space; Glucagon; Glucagon-Like Peptide 1; Insulinoma; Islets of Langerhans; Microscopy, Confocal; Microscopy, Electron; Pancreatic Neoplasms; Peptide Fragments; Protein Precursors; Tumor Cells, Cultured

2000
Pdx1 level defines pancreatic gene expression pattern and cell lineage differentiation.
    The Journal of biological chemistry, 2001, Jul-06, Volume: 276, Issue:27

    Topics: Animals; Cell Differentiation; Cell Line; Cell Nucleus; Cytoplasm; Gene Expression Regulation; Glucagon; Homeodomain Proteins; Insulinoma; Islets of Langerhans; Molecular Weight; Pancreas; Pancreatic Neoplasms; Rats; Trans-Activators; Tumor Cells, Cultured

2001
Over-expression of the glucagon-like peptide-1 receptor on INS-1 cells confers autocrine stimulation of insulin gene promoter activity: a strategy for production of pancreatic beta-cell lines for use in transplantation.
    Cell and tissue research, 2002, Volume: 307, Issue:2

    Topics: Animals; Autocrine Communication; Cell Line; Diabetes Mellitus; Enzyme Inhibitors; Exenatide; Gene Expression Regulation; Genetic Engineering; Glucagon; Glucagon-Like Peptide 1; Indoles; Insulin; Insulinoma; Islets of Langerhans; Islets of Langerhans Transplantation; Peptide Fragments; Peptides; Promoter Regions, Genetic; Protein Kinase C; Protein Precursors; Rats; Receptors, Peptide; Recombinant Proteins; Research Design; Second Messenger Systems; Tumor Cells, Cultured; Venoms

2002
An immunohistochemical approach to monitor the prolactin-induced activation of the JAK2/STAT5 pathway in pancreatic islets of Langerhans.
    The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 2002, Volume: 50, Issue:3

    Topics: Animals; Biological Transport; Blotting, Western; Cell Nucleus; Cytoplasm; DNA-Binding Proteins; Enzyme Activation; Glucagon; Immunohistochemistry; Insulin; Insulinoma; Islets of Langerhans; Janus Kinase 2; Microscopy, Confocal; Milk Proteins; Pancreatic Neoplasms; Phosphorylation; Phosphotyrosine; Prolactin; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Rats; Receptors, Prolactin; Somatostatin; STAT5 Transcription Factor; Trans-Activators; Tumor Cells, Cultured

2002
Expression of a novel zinc-finger cDNA, IA-1, is associated with rat AR42J cells differentiation into insulin-positive cells.
    Pancreas, 2002, Volume: 24, Issue:2

    Topics: Adult; Animals; Basic Helix-Loop-Helix Transcription Factors; Cell Differentiation; Culture Media, Conditioned; DNA-Binding Proteins; DNA, Complementary; Fetus; Gene Expression Regulation, Developmental; Glucagon; Glucagon-Like Peptide 1; Homeodomain Proteins; Humans; Insulin; Insulinoma; Islets of Langerhans; Mice; Peptide Fragments; Protein Precursors; Rats; Repressor Proteins; RNA, Messenger; Trans-Activators; Tumor Cells, Cultured; Zinc Fingers

2002
Use of the incretin hormone glucagon-like peptide-1 (GLP-1) for the detection of insulinomas: initial experimental results.
    European journal of nuclear medicine and molecular imaging, 2002, Volume: 29, Issue:5

    Topics: Animals; Chromatography, High Pressure Liquid; Feasibility Studies; Glucagon; Glucagon-Like Peptide 1; Insulinoma; Iodine Radioisotopes; Neoplasm Transplantation; Pancreatic Neoplasms; Peptide Fragments; Peptides; Protein Precursors; Radionuclide Imaging; Rats; Reproducibility of Results; Sensitivity and Specificity; Tissue Distribution; Tumor Cells, Cultured

2002
Insulinotropic hormone glucagon-like peptide-I(7-37) stimulation of proinsulin gene expression and proinsulin biosynthesis in insulinoma beta TC-1 cells.
    Endocrinology, 1992, Volume: 130, Issue:1

    Topics: Animals; Chloramphenicol O-Acetyltransferase; Cyclic AMP; Diabetes Mellitus, Type 2; Gene Expression; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Insulin; Insulin Secretion; Insulinoma; Mice; Pancreatic Neoplasms; Peptide Fragments; Peptides; Proinsulin; Promoter Regions, Genetic; RNA, Messenger; Tumor Cells, Cultured

1992
Solubilization of active GLP-1 (7-36)amide receptors from RINm5F plasma membranes.
    FEBS letters, 1992, Apr-06, Volume: 300, Issue:3

    Topics: Animals; Cations; Detergents; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Insulinoma; Pancreatic Neoplasms; Peptide Fragments; Peptides; Protein Binding; Rats; Receptors, Cell Surface; Receptors, Glucagon; Solubility; Thionucleotides; Tumor Cells, Cultured

1992
Characterization of binding sites for oxyntomodulin on a somatostatin-secreting cell line (RIN T3).
    Endocrinology, 1992, Volume: 130, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclases; Animals; Binding Sites; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Glucagon; Glucagon-Like Peptides; Insulinoma; Iodine Radioisotopes; Oxyntomodulin; Rats; Somatostatin; Tumor Cells, Cultured

1992
Galanin inhibits proinsulin gene expression stimulated by the insulinotropic hormone glucagon-like peptide-I(7-37) in mouse insulinoma beta TC-1 cells.
    Endocrinology, 1992, Volume: 130, Issue:5

    Topics: Adenylate Cyclase Toxin; Animals; Blotting, Northern; Cell Line; Chloramphenicol O-Acetyltransferase; Colforsin; Galanin; Gene Expression; Gene Expression Regulation, Neoplastic; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Insulinoma; Kinetics; Mice; Models, Biological; Pancreatic Neoplasms; Peptide Fragments; Peptides; Pertussis Toxin; Proinsulin; RNA, Neoplasm; Transfection; Virulence Factors, Bordetella

1992
Glucagonlike peptide-1(7-36)amide suppresses glucagon secretion and decreases cyclic AMP concentration in cultured In-R1-G9 cells.
    Biochemical and biophysical research communications, 1992, Jul-15, Volume: 186, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Clone Cells; Cricetinae; Cyclic AMP; Dose-Response Relationship, Drug; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Insulinoma; Kinetics; Pancreatic Neoplasms; Peptide Fragments; Peptides

1992
Multiple hormone secretion and gene expression in clones isolated from rat insulinoma cell lines.
    The Kobe journal of medical sciences, 1992, Volume: 38, Issue:3

    Topics: Animals; Clone Cells; Gene Expression; Genes, ras; Glucagon; In Situ Hybridization; Insulin; Insulin Secretion; Insulinoma; Pancreatic Neoplasms; Ploidies; Rats; Tumor Cells, Cultured

1992
[Insulinoma and octreotide].
    Nederlands tijdschrift voor geneeskunde, 1992, Jun-20, Volume: 136, Issue:25

    Topics: Glucagon; Humans; Hypoglycemia; Insulinoma; Octreotide; Pancreatic Neoplasms

1992
Monoclonal antibody-mediated cytotoxicity against rat beta cells detected in vitro does not cause beta-cell destruction in vivo.
    Diabetologia, 1992, Volume: 35, Issue:7

    Topics: Animals; Antibodies, Monoclonal; Antibody-Dependent Cell Cytotoxicity; Cell Line; Glucagon; Hybridomas; Insulin; Insulinoma; Islets of Langerhans; Mice; Mice, Inbred BALB C; Pancreatic Neoplasms; Rats

1992
Homologous desensitization of the insulinotropic glucagon-like peptide-I (7-37) receptor on insulinoma (HIT-T15) cells.
    Endocrinology, 1991, Volume: 128, Issue:6

    Topics: Cyclic AMP; Down-Regulation; Gastric Inhibitory Polypeptide; Glucagon; Glucose; Insulin; Insulinoma; Pancreatic Neoplasms; Perfusion; Receptors, Gastrointestinal Hormone; Receptors, Glucagon; Tumor Cells, Cultured

1991
Oxyntomodulin and related peptides control somatostatin secretion in RIN T3 cells.
    Biochimica et biophysica acta, 1991, Nov-12, Volume: 1095, Issue:3

    Topics: Animals; Calcium; Carbachol; Cyclic AMP; Dose-Response Relationship, Drug; Glucagon; Glucagon-Like Peptides; In Vitro Techniques; Inositol Phosphates; Insulinoma; Oxyntomodulin; Peptide Fragments; Rats; Secretory Rate; Somatostatin; Time Factors; Tumor Cells, Cultured

1991
The pancreatic islet-specific glucagon G3 transcription factors recognize control elements in the rat somatostatin and insulin-I genes.
    Molecular endocrinology (Baltimore, Md.), 1991, Volume: 5, Issue:10

    Topics: Animals; Base Sequence; Binding Sites; Cell Nucleus; Cricetinae; Enhancer Elements, Genetic; Glucagon; Immunoblotting; Insulin; Insulinoma; Islets of Langerhans; Molecular Sequence Data; Oligodeoxyribonucleotides; Pancreatic Neoplasms; Rats; Sequence Homology, Nucleic Acid; Somatostatin; Transcription Factors

1991
Differential glucocorticoid regulation of glucagon gene expression in cell lines derived from rat and hamster islet cell tumors.
    Cancer research, 1991, Feb-15, Volume: 51, Issue:4

    Topics: Adenoma, Islet Cell; Animals; Blotting, Northern; Cell Line; Chloramphenicol O-Acetyltransferase; Cricetinae; Dexamethasone; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Glucagon; Glucocorticoids; In Vitro Techniques; Insulinoma; Male; Pancreatic Neoplasms; Radioimmunoassay; Rats; Rats, Inbred Strains; RNA; Transfection

1991
Prolonged maximal stimulation of insulin secretion in healthy subjects does not provoke preferential release of proinsulin.
    Pancreas, 1991, Volume: 6, Issue:6

    Topics: Adult; C-Peptide; Diabetes Mellitus, Type 2; Female; Glucagon; Humans; Hyperglycemia; Insulin; Insulin Secretion; Insulinoma; Male; Pancreatic Neoplasms; Proinsulin; Tolbutamide

1991
Islet amyloid polypeptide and insulin expression are controlled differently in primary and transformed islet cells.
    Molecular endocrinology (Baltimore, Md.), 1991, Volume: 5, Issue:1

    Topics: Amyloid; Animals; Animals, Newborn; Cell Line; Cell Line, Transformed; Gene Expression Regulation; Glucagon; Glucagonoma; Growth Hormone; Humans; Immunohistochemistry; Insulin; Insulinoma; Islet Amyloid Polypeptide; Islets of Langerhans; Mice; Pancreatic Neoplasms; Rats; RNA, Messenger; Simian virus 40; Transfection

1991
Stimulatory effects of glucagon-like peptides on human insulinoma cells and insulin-releasing clonal RINm5F cells.
    Diabetes research (Edinburgh, Scotland), 1990, Volume: 13, Issue:2

    Topics: Adult; Animals; Cell Line; Cyclic AMP; Female; Glucagon; Glucose; Humans; Insulin; Insulin Secretion; Insulinoma; Kinetics; Pancreatic Neoplasms; Peptide Fragments; Rats; Structure-Activity Relationship

1990
Human and rat amylin have no effects on insulin secretion in isolated rat pancreatic islets.
    Biochemical and biophysical research communications, 1991, Jun-28, Volume: 177, Issue:3

    Topics: Amyloid; Animals; Cell Line; Cells, Cultured; Cricetinae; Glucagon; Glucose; Humans; In Vitro Techniques; Insulin; Insulin Secretion; Insulinoma; Islet Amyloid Polypeptide; Islets of Langerhans; Kinetics; Male; Pancreatic Neoplasms; Rats; Rats, Inbred Strains

1991
Glucagon-like peptide-I analogs: effects on insulin secretion and adenosine 3',5'-monophosphate formation.
    Endocrinology, 1990, Volume: 126, Issue:4

    Topics: Animals; Cell Line; Cyclic AMP; Dose-Response Relationship, Drug; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Insulin; Insulin Secretion; Insulinoma; Male; Pancreas; Peptide Fragments; Peptides; Rats; Rats, Inbred Strains

1990
A pancreatic islet cell-specific enhancer-like element in the glucagon gene contains two domains binding distinct cellular proteins.
    The Journal of biological chemistry, 1990, May-25, Volume: 265, Issue:15

    Topics: Adenoma, Islet Cell; Animals; Base Sequence; Cell Line; Cell Nucleus; Deoxyribonucleases; DNA-Binding Proteins; DNA, Neoplasm; Enhancer Elements, Genetic; Glucagon; HeLa Cells; Humans; Insulinoma; Molecular Sequence Data; Mutation; Nucleotide Mapping; Oligonucleotide Probes; Pancreatic Neoplasms; Rats; Transcription, Genetic

1990
Dexamethasone pretreatment of rat insulinoma cells decreases binding of glucagon-like peptide-1(7-36)amide.
    The Journal of endocrinology, 1990, Volume: 126, Issue:3

    Topics: Animals; Cyclic AMP; Dexamethasone; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucocorticoids; Insulinoma; Mifepristone; Pancreatic Neoplasms; Peptide Fragments; Peptides; Protein Binding; Rats; Time Factors; Tumor Cells, Cultured

1990
P19, a hormonally regulated phosphoprotein of peptide hormone-producing cells: secretagogue-induced phosphorylation in AtT-20 mouse pituitary tumor cells and in rat and hamster insulinoma cells.
    Endocrinology, 1986, Volume: 119, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenoma, Islet Cell; Adrenocorticotropic Hormone; Animals; Colforsin; Corticotropin-Releasing Hormone; Cricetinae; Cyclic AMP; Electrophoresis, Polyacrylamide Gel; Glucagon; Insulinoma; Isoproterenol; Pancreatic Neoplasms; Phosphoproteins; Phosphorylation; Pituitary Neoplasms; Potassium; Rats; Tetradecanoylphorbol Acetate

1986
Structure, function, and immunogenicity of human insulinoma cells.
    Diabetes, 1988, Volume: 37, Issue:9

    Topics: 1-Methyl-3-isobutylxanthine; Adenoma, Islet Cell; Adult; C-Peptide; Fluorescent Antibody Technique; Glucagon; Glucose; Humans; Insulin; Insulin Secretion; Insulinoma; Lymphocyte Culture Test, Mixed; Lymphocytes; Microscopy, Electron; Pancreatic Neoplasms; Tolbutamide; Tumor Cells, Cultured

1988
Myelin basic protein present in the acid extracts of rat hypothalami releases insulin and glucagon from isolated rat pancreatic islets.
    Acta physiologica Scandinavica, 1988, Volume: 134, Issue:2

    Topics: Amino Acids; Animals; Biological Assay; Cell Line, Transformed; Glucagon; Hypothalamus; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Molecular Weight; Myelin Basic Protein; Neutralization Tests; Pancreatic Neoplasms; Radioimmunoassay; Rats; Tissue Extracts

1988
Aggravation of hypoglycemia in insulinoma patients by the long-acting somatostatin analogue octreotide (Sandostatin).
    Acta endocrinologica, 1989, Volume: 121, Issue:1

    Topics: Adenoma, Islet Cell; Aged; C-Peptide; Female; Glucagon; Humans; Hypoglycemia; Insulin; Insulinoma; Octreotide; Pancreatic Neoplasms

1989
Characterization of the receptor for glucagon-like peptide-1(7-36)amide on plasma membranes from rat insulinoma-derived cells by covalent cross-linking.
    Journal of molecular endocrinology, 1989, Volume: 2, Issue:2

    Topics: Adenoma, Islet Cell; Animals; Cell Line; Cell Membrane; Cross-Linking Reagents; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Insulinoma; Peptides; Rats; Receptors, Cell Surface; Receptors, Glucagon

1989
Signal transmission after GLP-1(7-36)amide binding in RINm5F cells.
    The American journal of physiology, 1989, Volume: 257, Issue:3 Pt 1

    Topics: Adenoma, Islet Cell; Animals; Calcium; Cell Line; Cell Membrane; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Insulinoma; Membrane Potentials; Peptide Fragments; Peptides; Rats; Signal Transduction; Tumor Cells, Cultured

1989
Internalization of glucagon-like peptide-1(7-36)amide in rat insulinoma cells.
    Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie, 1989, Volume: 189, Issue:4

    Topics: Adenoma, Islet Cell; Animals; Chloroquine; Chromatography, High Pressure Liquid; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Insulinoma; Kinetics; Pancreatic Neoplasms; Peptides; Rats; Receptors, Cell Surface; Receptors, Glucagon; Temperature; Tumor Cells, Cultured

1989
A case of multiple endocrine neoplasia (MEN) type 1; the immunohistochemical and ultrastructural studies of its tumors and the analysis of hormones in tumor extracts.
    Endocrinologia japonica, 1989, Volume: 36, Issue:1

    Topics: Adenoma; Adenoma, Islet Cell; Adult; Chromatography, Gel; Chromatography, High Pressure Liquid; Female; Glucagon; Humans; Immunoenzyme Techniques; Immunohistochemistry; Insulin; Insulinoma; Microscopy, Electron; Molecular Weight; Multiple Endocrine Neoplasia; Pancreatic Neoplasms; Pancreatic Polypeptide; Parathyroid Hormone; Parathyroid Neoplasms; Pituitary Neoplasms; Somatostatin

1989
The endocrine pancreas in patients with insulinomas. An immunocytochemical and ultrastructural study of the nontumoral tissue with morphometrical evaluations.
    International journal of pancreatology : official journal of the International Association of Pancreatology, 1989, Volume: 5, Issue:1

    Topics: Adenoma, Islet Cell; Adult; Aged; Cell Division; Cytophotometry; Female; Glucagon; Humans; Immunoenzyme Techniques; Insulin; Insulinoma; Islets of Langerhans; Male; Microscopy, Electron; Middle Aged; Pancreatic Hormones; Pancreatic Neoplasms; Pancreatic Polypeptide; Somatostatin

1989
Interaction of glucagon-like peptide-1(7-36)amide and somatostatin-14 in RINm5F cells and in the perfused rat pancreas.
    Pancreas, 1989, Volume: 4, Issue:6

    Topics: Adenoma, Islet Cell; Animals; Cell Line; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Insulin; Insulinoma; Male; Pancreas; Peptide Fragments; Peptides; Rats; Somatostatin; Tumor Cells, Cultured

1989
Truncated glucagon-like peptide-1 (proglucagon 78-107 amide), an intestinal insulin-releasing peptide, has specific receptors on rat insulinoma cells (RIN 5AH).
    FEBS letters, 1988, Feb-29, Volume: 229, Issue:1

    Topics: Adenoma, Islet Cell; Animals; Binding, Competitive; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Insulin; Insulinoma; Intestinal Mucosa; Intestines; Kinetics; Pancreatic Neoplasms; Peptides; Rats; Receptors, Cell Surface; Receptors, Glucagon

1988
Receptors for glucagon-like peptide-1(7-36) amide on rat insulinoma-derived cells.
    The Journal of endocrinology, 1988, Volume: 116, Issue:3

    Topics: Adenoma, Islet Cell; Animals; Binding, Competitive; Cell Line; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Insulinoma; Intestinal Mucosa; Jejunum; Pancreatic Neoplasms; Peptide Fragments; Peptides; Rats; Receptors, Cell Surface; Receptors, Glucagon

1988
Characterization of secretory responses of a glucagon-producing In-R1-G9 cell line.
    Diabetes research and clinical practice, 1988, Feb-19, Volume: 4, Issue:3

    Topics: Adenoma, Islet Cell; Animals; Calcium; Clone Cells; Colchicine; Cricetinae; Cycloheximide; Cytoplasmic Granules; Glucagon; Insulinoma; Monensin; Pancreatic Neoplasms; Tumor Cells, Cultured

1988
The use of glucagon challenge tests in the diagnostic evaluation of hypoglycemia due to hepatoma and insulinoma.
    The Journal of clinical endocrinology and metabolism, 1988, Volume: 67, Issue:3

    Topics: Adenoma, Islet Cell; Adult; Aged; Aged, 80 and over; Blood Glucose; C-Peptide; Carcinoma, Hepatocellular; Female; Glucagon; Humans; Hypoglycemia; Insulin; Insulinoma; Liver Neoplasms; Male; Middle Aged; Pancreatic Neoplasms

1988
Symptomatic secondary hormone syndromes in patients with established malignant pancreatic endocrine tumors.
    The New England journal of medicine, 1988, Sep-08, Volume: 319, Issue:10

    Topics: Adenoma, Islet Cell; Adult; Aged; Gastrins; Gastrointestinal Hemorrhage; Glucagon; Glucagonoma; Hormones; Humans; Insulinoma; Middle Aged; Pancreatic Neoplasms; Time Factors; Vasoactive Intestinal Peptide; Vipoma; Zollinger-Ellison Syndrome

1988
[Iatrogenic glucagonoma syndrome?].
    Annales de dermatologie et de venereologie, 1988, Volume: 115, Issue:6-7

    Topics: Adenoma, Islet Cell; Amino Acids; Female; Glucagon; Glucagonoma; Humans; Hypoglycemia; Iatrogenic Disease; Insulinoma; Middle Aged; Pancreatic Neoplasms; Skin Diseases; Syndrome

1988
[Features of incretory function of the pancreas in patients with insulinoma].
    Terapevticheskii arkhiv, 1988, Volume: 60, Issue:9

    Topics: Adenoma, Islet Cell; Adolescent; Adult; Blood Glucose; C-Peptide; Female; Glucagon; Humans; Insulin; Insulinoma; Male; Middle Aged; Pancreatic Hormones; Pancreatic Neoplasms; Predictive Value of Tests

1988
Nesidioblastosis and endocrine hyperplasia of the pancreas: a secondary phenomenon.
    Human pathology, 1986, Volume: 17, Issue:1

    Topics: Adult; Aged; Child, Preschool; Glucagon; Humans; Hyperinsulinism; Hyperplasia; Infant; Infant, Newborn; Insulin; Insulinoma; Islets of Langerhans; Middle Aged; Pancreas; Pancreatic Diseases; Pancreatic Neoplasms; Pancreatic Polypeptide; Somatostatin

1986
Isolation of glucagon-secreting cell lines by cloning insulinoma cells.
    In vitro cellular & developmental biology : journal of the Tissue Culture Association, 1986, Volume: 22, Issue:3 Pt 1

    Topics: Adenoma, Islet Cell; Animals; Clone Cells; Cricetinae; Culture Media; Glucagon; Glucose; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Karyotyping; Microscopy, Electron; Pancreatic Neoplasms; Somatostatin

1986
Effects of transplantation and resection of a radiation-induced rat insulinoma on glucose homeostasis and the endocrine pancreas.
    British journal of cancer, 1986, Volume: 54, Issue:4

    Topics: Adenoma, Islet Cell; Animals; Blood Glucose; Glucagon; Glucose; Homeostasis; Insulin; Insulinoma; Islets of Langerhans; Male; Neoplasm Transplantation; Neoplasms, Radiation-Induced; Pancreatic Neoplasms; Rats; Rats, Inbred Strains; Somatostatin

1986
Multipotential phenotypic expression of genes encoding peptide hormones in rat insulinoma cell lines.
    The Journal of clinical investigation, 1987, Volume: 79, Issue:2

    Topics: Adenoma, Islet Cell; Animals; Cell Line; Clone Cells; Genes; Glucagon; Insulin; Insulinoma; Nucleic Acid Hybridization; Pancreatic Neoplasms; Pancreatic Polypeptide; Phenotype; Protein Biosynthesis; Rats; Somatostatin

1987
Metabolic effects and secretory properties of a radiation-induced transplantable rat insulinoma.
    Comparative biochemistry and physiology. A, Comparative physiology, 1987, Volume: 87, Issue:1

    Topics: Adenoma, Islet Cell; Animals; Arginine; Blood Glucose; Body Weight; Deoxyglucose; Epinephrine; Feeding Behavior; Glucagon; Glyburide; Insulin; Insulinoma; Male; Neoplasms, Radiation-Induced; Pancreatic Neoplasms; Rats; Rats, Inbred Strains

1987
Distribution of somatostatin receptors in RINm5F insulinoma cells.
    Endocrinology, 1988, Volume: 122, Issue:3

    Topics: Adenoma, Islet Cell; Animals; Cell Fractionation; Cell Membrane; Colforsin; Cytoplasmic Granules; Cytosol; Glucagon; Glyceraldehyde; Insulin; Insulin Secretion; Insulinoma; Iodine Radioisotopes; Kinetics; Leucine; Microsomes; Pancreatic Neoplasms; Rats; Receptors, Neurotransmitter; Receptors, Somatostatin; Somatostatin; Tumor Cells, Cultured

1988
Remission of symptoms of chemotherapy-refractory metastatic insulinoma using octreotide.
    Drug intelligence & clinical pharmacy, 1988, Volume: 22, Issue:2

    Topics: Adenoma, Islet Cell; Antineoplastic Agents; Drug Resistance; Female; Gastrins; Glucagon; Humans; Insulin; Insulinoma; Middle Aged; Neoplasm Metastasis; Octreotide; Pancreatic Neoplasms; Somatostatin

1988
Expression of peptide hormone genes in human islet cell tumors.
    Diabetes, 1988, Volume: 37, Issue:12

    Topics: Adenoma, Islet Cell; Animals; Blotting, Northern; Genes; Glucagon; Glucagonoma; Humans; Insulin; Insulinoma; Pancreatic Neoplasms; Pancreatic Polypeptide; Rats; RNA, Messenger; Somatostatin

1988
Streptozotocin effective for treating multiple-hormone-producing malignant islet cell tumor.
    The Japanese journal of surgery, 1985, Volume: 15, Issue:1

    Topics: Adenoma, Islet Cell; Blood Glucose; C-Peptide; Female; Glucagon; Humans; Insulin; Insulinoma; Liver Neoplasms; Middle Aged; Pancreatic Neoplasms; Serotonin; Streptozocin

1985
Characteristics of the interaction of the glucagon receptor, cAMP, and insulin secretion in parent cells and clone 5F of a cultured rat insulinoma.
    Diabetes, 1985, Volume: 34, Issue:8

    Topics: Adenoma, Islet Cell; Amino Acids; Animals; Cell Line; Clone Cells; Cyclic AMP; Deoxyglucose; Glucagon; Insulin; Insulin Secretion; Insulinoma; Pancreatic Neoplasms; Rats; Receptors, Cell Surface; Receptors, Glucagon

1985
[Biochemical diagnosis of insulinoma: correlations between blood glucose, blood insulin and the titer of plasma non-esterified fatty acids during fasting and during various diagnostic tests].
    Minerva medica, 1985, Sep-29, Volume: 76, Issue:37

    Topics: Adenoma, Islet Cell; Adult; Aged; Blood Glucose; C-Peptide; Epinephrine; Fasting; Fatty Acids, Nonesterified; Female; Glucagon; Glucose Tolerance Test; Humans; Insulin; Insulinoma; Male; Middle Aged; Tolbutamide

1985
Accurate localization of insulinoma using percutaneous transhepatic portal venous sampling--usefulness of simultaneous measurement of plasma insulin and glucagon levels.
    Clinical endocrinology, 1985, Volume: 23, Issue:5

    Topics: Adenoma, Islet Cell; Adult; Aged; Blood Specimen Collection; Female; Glucagon; Humans; Insulin; Insulinoma; Male; Middle Aged; Pancreatic Neoplasms; Portal Vein

1985
Neoplasia and hyperplasia of pancreatic endocrine tissue in the rat: an immunocytochemical study.
    Veterinary pathology, 1986, Volume: 23, Issue:1

    Topics: Adenoma, Islet Cell; Animals; Female; Glucagon; Hyperplasia; Immunoassay; Insulin; Insulinoma; Islets of Langerhans; Male; Pancreatic Neoplasms; Rats; Rats, Inbred Strains; Species Specificity

1986
Effect of phorbol esters on glucagon secretion from a glucagon-secreting clonal cell line. Synergistic effects of A23187 and theophylline.
    Diabetes research and clinical practice, 1986, Volume: 2, Issue:1

    Topics: Adenoma, Islet Cell; Animals; Calcimycin; Cell Line; Clone Cells; Cricetinae; Drug Synergism; Glucagon; In Vitro Techniques; Insulinoma; Pancreatic Neoplasms; Phorbols; Tetradecanoylphorbol Acetate; Theophylline

1986
Effects of a transplantable insulinoma upon regulatory peptide concentrations in the gastrointestinal tract of the rat.
    Diabetologia, 1986, Volume: 29, Issue:5

    Topics: Adenoma, Islet Cell; Animals; Blood Glucose; Eating; Energy Intake; Gastrointestinal Hormones; Glucagon; Insulin; Insulinoma; Male; Neoplasm Transplantation; Pancreatic Neoplasms; Rats; Rats, Inbred Strains

1986
[Studies on the diagnosis of insulinoma].
    [Hokkaido igaku zasshi] The Hokkaido journal of medical science, 1987, Volume: 62, Issue:1

    Topics: Adenoma, Islet Cell; Adolescent; Adult; Aged; Blood Glucose; C-Peptide; Female; Glucagon; Humans; Insulin; Insulin Secretion; Insulinoma; Male; Middle Aged; Pancreatic Neoplasms; Tolbutamide

1987
Proglucagon gene expression and posttranslational processing in a hamster islet cell line.
    Endocrinology, 1988, Volume: 123, Issue:4

    Topics: Animals; Cell Line; Cricetinae; Genes; Glucagon; Insulinoma; Methylation; Pancreatic Neoplasms; Proglucagon; Protein Precursors; Protein Processing, Post-Translational; RNA, Neoplasm; Transcription, Genetic

1988
Interaction of glucagon-like peptide-I (7-37) and somatostatin-14 on signal transduction and proinsulin gene expression in beta TC-1 cells.
    Metabolism: clinical and experimental, 1994, Volume: 43, Issue:6

    Topics: Adenylyl Cyclases; Animals; Colforsin; Cyclic AMP; Drug Interactions; Gene Expression; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Insulinoma; Mice; Pancreatic Neoplasms; Peptides; Proinsulin; Receptors, Cell Surface; Receptors, Glucagon; Signal Transduction; Somatostatin; Tumor Cells, Cultured

1994