glucagon has been researched along with Alloxan Diabetes in 968 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 473 (48.86) | 18.7374 |
| 1990's | 165 (17.05) | 18.2507 |
| 2000's | 125 (12.91) | 29.6817 |
| 2010's | 159 (16.43) | 24.3611 |
| 2020's | 46 (4.75) | 2.80 |
| Authors | Studies |
|---|---|
| Cheng, M; Fu, CL; Li, XL; Xu, M; Yu, F; Yu, X | 1 |
| Asadi, F; Dhanvantari, S | 1 |
| Flatt, PR; Irwin, N; Lafferty, R; Moffett, RC; Mohan, S; Tanday, N | 1 |
| Charlotte Moffett, R; Flatt, PR; Irwin, N; Sarnobat, D; Tarasov, AI | 1 |
| Guanfu, L; Jun, S; Qiaoli, G; Xiaoyun, W; Xuanjun, W; Yinghao, W | 1 |
| Meamar, R; Rad, MG; Sharifi, M; Soltani, N | 1 |
| Flatt, PR; Irwin, N; Lafferty, RA; Tanday, N | 1 |
| Chen, J; Grayson, TB; Jing, G; Jo, S; Lu, B; Shalev, A; Xu, G | 1 |
| Cui, X; Gu, L; Hong, T; Lin, X; Wei, R; Yang, J; Yang, K | 1 |
| Charlotte Moffett, R; Flatt, PR; Irwin, N; Lafferty, RA; Sarnobat, D; Tarasov, AI | 1 |
| Chen, X; Liu, H; Lu, Y; Lu, Z; Meng, F; Zhao, H | 1 |
| Barco, VS; Corrente, JE; Cruz, LL; Damasceno, DC; Gallego, FQ; Iessi, IL; Karki, B; Paula, VG; Sinzato, YK; Souza, MR; Volpato, GT | 1 |
| Cui, X; Fu, W; Hong, T; Li, F; Liu, J; Wang, K; Wei, R; Wei, T; Xia, L; Yang, J | 1 |
| Buhler, LH; Cheng, C; Deng, S; Geng, Z; Gonelle-Gispert, C; Huang, T; Li, T; Li, Y; Wang, H; Wang, Y; Zhang, Q; Zhao, Y; Zhou, Q | 1 |
| Caicedo, A; Panzer, JK; Tamayo, A | 1 |
| Cui, X; Gu, L; Hong, T; Jiang, Y; Li, F; Lin, X; Wang, D; Wang, K; Wei, R; Wei, T; Yang, J; Yang, K | 1 |
| Agranovich, B; Assa, M; Avrahami, D; Bernal-Mizrachi, E; Cerasi, E; Glaser, B; Gottlieb, E; Helman, A; Jackson, F; Kadosh, L; Kogot-Levin, A; Leibowitz, G; Malka, A; Piran, R; Riahi, Y | 1 |
| Bonner, C; Bousquet, C; Coddeville, A; Daoudi, M; Delalleau, N; Gmyr, V; Hubert, T; Kerr-Conte, J; Martineau, Y; Moerman, E; Pasquetti, G; Pattou, F; Quenon, A; Saponaro, C; Staels, B; Thévenet, J; Vantyghem, MC | 1 |
| Deng, B; Gilbert, RG; Liu, X; Liu, Y; Wang, K; Wu, Z; Yang, L; Zhang, Y | 1 |
| Andersen, B; Bokhari, MH; Busby, O; Cannon, B; Conde-Frieboes, KW; Fels, JJ; Nedergaard, J; Paulsson, JF; Rakipovski, G; Raun, K; Zouhar, P | 1 |
| Avraham, Y; Bi, X; Cai, X; Dai, Y; He, L; Huang, W; Li, C; Liu, C; Qian, H; Sun, L; Tong, J; Wang, Y; Zhou, J | 1 |
| Jiang, B; Jin, J; Liu, P; Sheng, L; Song, Y; Zhang, H; Zhong, Y; Zhou, H | 1 |
| Flatt, PR; Irwin, N; Moffett, RC; Tanday, N | 2 |
| Abbasnezhad, A; Abd El-Ghafar, OA; Abhilash, L; Abouzid, KAM; Achberger, AM; Ackerman, S; Akhatayeva, Z; Akin, D; Al-Kaysi, RO; Alakhdar, AA; Alame, M; Aleksic Sabo, V; Alinezhadbalalami, N; Allen, JD; Alonso, JM; Alqatani, S; Alsayed, B; Álvarez Larraondo, M; Alvarez, M; Amini, SB; An, Z; Anasir, MI; Anderson, GH; Andremont, A; Andrés, S; Angel, S; Anigboro, AA; Anini, Y; Antonides, CFJ; Arafa, K; Arafa, RK; Aryal, UK; Asbaghi, O; Assefa, MK; Atyah, M; Avwioroko, OJ; Ayora-Talavera, G; Azpilikueta, A; Azyazov, VN; Ba, YF; Bachmann, KF; Badoual, J; Bae, SJ; Baek, SH; Bahrami, B; Bai, J; Baid-Agrawal, S; Bailey, MR; Baillie, JK; Balani, N; Balcar, VJ; Banica, T; Banks, L; Barb, J; Bardeen, CJ; Barrett, HE; Bartnikowski, N; Bashir, R; Battaglia, M; Bautista-Hernández, V; Becker, B; Beekman, FJ; Benidir, M; Benjelloun, M; Bentley, RF; Bergé, J; Berger, D; Bernsen, MR; Berraondo, P; Bhattacharya, R; Bhayani, SB; Bi, W; Bi, X; Bi, YL; Bi, Z; Bian, K; Biesecker, LG; Billadeau, DD; Blaszczyk, R; Blum, JL; Boachie, R; Boelte, K; Bogers, AJJC; Boileau, I; Bonduelle, C; Bonny, O; Bonsu, JM; Boos, LA; Borges-Argáez, R; Bouchard, PA; Boudot, C; Bourgeade-Delmas, S; Boutet-Robinet, E; Boyle, AJ; Branigan, D; Briones, S; Broniowska, KA; Brossas, JY; Brown, WA; Brzezinska, J; Buitron, G; Burnier, M; Bursulaya, B; Burton, PR; Bush, AA; Busuttil, RW; Cabello-Aguilar, S; Cáceres-Farfán, M; Cacheux, V; Caffrey, PJ; Cai, B; Cai, Q; Cai, S; Cai, Y; Calders, P; Cammarota, G; Campbell, DA; Cancelli, C; Cao, Q; Cao, WH; Cao, X; Capet, M; Capoluongo, E; Carey, ME; Carnero, M; Carrasco, LI; Carreno, J; Carrillo-Reyes, J; Casini, I; Cassar, M; Catalan, G; Cattamanchi, A; Cazares-Granillo, M; Celie, B; Cen, YK; Cena, H; Cerbo, RM; Ceron, E; Cetina-Montejo, L; Chaâbane-Banaoues, R; Chabanet, C; Chace-Donahue, F; Chalfun-Júnior, A; Chan-Balan, R; Chang, CS; Chen, CS; Chen, D; Chen, J; Chen, L; Chen, PN; Chen, Q; Chen, S; Chen, W; Chen, WP; Chen, X; Chen, Z; Cheng, H; Cheng, J; Cheng, Q; Cheng, T; Chi, T; Chianelli, D; Chieppa, M; Child, CJ; Cho, JH; Cho, JY; Chogtu, B; Choi, GH; Choi, J; Choi, M; Choi, NG; Cholu, CO; Chow, ES; Chowdhury, AH; Chu, PC; Chu, Q; Chu, S; Chua, H; Chung, T; Chunyan, L; Church, JS; Civardi, E; Cobiella, J; Colinge, J; Collado, CJ; Collins, TJ; Cong, LM; Conkrite, KL; Cope, SJ; Corbett, JA; Cornet, M; Cornillot, E; Corvaisier, S; Costes-Martineau, V; Courtioux, B; Coussens, M; Covino, M; Criado, A; Cui, J; Cui, Y; Cunitz, BW; Curry, AE; Cussó, L; D'Urzo, AD; D'Urzo, KA; Dabbous, S; Dahlgren, RA; Dai, H; Dai, T; Dai, W; Dalinghaus, M; Dang, S; Davalos, RV; Davidson, H; de Andrea, CE; De Angelis, M; de Blois, E; de Carvalho, PA; De Clercq, E; De Giuseppe, R; de Jong, M; De Langhe, S; De Oliveira, L; de Souza Pinto Lemgruber, R; de Souza, LB; de Swart, J; De Wandele, I; de Woestijne, PCV; Delaney, S; Delorme, M; Delvenne, P; Deng, L; Deng, Z; Denkinger, CM; der Meulen, MHV; Deraeve, C; Desco, M; DeSilva, S; Destere, A; Dhali, A; Di Ciano, P; Dias-Santagata, D; Diskin, SJ; Djè, MK; Doddipatla, S; Doerr, AJ; Dokla, EME; Domiciano, D; Domingo, N; Dong, C; Dong, J; Dong, Q; Dong, S; Dong, X; Dong, Z; Douair, I; Douglas, TA; Doyle, SM; Drain, PK; Du, K; Du, L; Du, Q; Du, S; Duan, C; Duan, H; Duan, J; Duan, S; Duan, W; Dueluzeau, R; Dukic, L; Dunmire, BL; Duvauchelle, T; Dymek, B; Dzwonek, K; Earnest, A; Eckardt, KU; El Ghadraoui, L; El Massoudi, S; Elloumi, F; Elnour, IE; Embarak, S; Ende, M; England, K; Enikeev, D; Enyedy, I; Epple, R; Erickson, GE; Eriksson, J; Erndt-Marino, J; Errachidi, F; Etxeberria, I; Evan, AP; Fairlamb, AH; Falahi, E; Fan, CC; Fan, H; Fan, M; Fan, MZ; Fan, S; Fan, Y; Fang, CS; Fang, J; Fang, X; Fang, Z; Farmany, A; Farooqi, A; Farouk, HO; Fazelipour, S; Feng, D; Feng, J; Feng, JX; Feng, YL; Ferraz, SL; Ferreira, CR; Figenshau, RS; Finn, AV; Fiseha, T; Fleischer, AS; Fogleman, AD; Fontaine, O; Ford, CR; Fouladvand, F; Four, M; Fousteri, G; Francis, JR; Fraser, JF; Frazier, RP; Fu, H; Fu, P; Fu, YJ; Fujishima, A; Fuster, V; Gabilan, JC; Gagliani, N; Gai, QY; Galán-Arriola, C; Gale, P; Galimova, GR; Galkin, A; Gallo, A; Gallo, AA; Gang, DD; Ganschow, S; Gao, C; Gao, F; Gao, GP; Gao, H; Gao, K; Gao, M; Gao, MY; Gao, P; Gao, R; Gao, S; Gao, WJ; Gao, Y; Garbacz, P; García Ruiz, L; Garcia, EM; Garofoli, F; Gasbarrini, A; Gattinoni, L; Gaudig, M; Gbureck, U; Ge, X; Genko, N; Gentile, GL; George, MW; Gerety, GF; Gestwicki, JE; Geusens, PP; Ghassemi, M; Giardina, JD; Giebultowicz, JM; Gifford, CA; Gijsen, FJH; Gilfillan, R; Gilson, E; Gingl, K; Giuliano, C; Glybochko, P; Goessler, W; Gofflot, S; Golab, J; Goldstein, A; Golebiowski, A; Gómez, L; Gómez-Carballo, J; Gonçalves, PEO; Gonzales, R; Gonzalez-Cotto, M; González-Fernández, D; Gonzalez-Lopez de Turiso, F; Goodman, JM; Govinda Raju, S; Grimm, J; Gross, AJ; Gruenheid, S; Gu, C; Gu, FF; Gu, S; Gu, Z; Guest, RL; Gui, C; Gui, J; Guillem, A; Guo, G; Guo, L; Guo, Q; Guo, S; Guo, SW; Guo, W; Guo, Y; Guo, YG; Guo, Z; Guretzky, JA; Haenggi, M; Hahn, MS; Hakkola, J; Halim, AA; Hampel, D; Han, B; Han, BH; Han, D; Han, G; Han, J; Han, LZ; Han, R; Han, S; Han, X; Han, Z; Handley, MA; Hanke, I; Hannongbua, S; Hao, P; Happ, JT; Hara, M; Haraux, F; Hare, JL; Harper, JD; Hartley, AM; Harvey, E; Hashimoto, K; Hassan, HM; Hautajärvi, H; Hayton, TW; He, C; He, H; He, HJ; He, WP; He, Y; He, Z; Hedrick, V; Heffernan, JK; Hegrová, J; Heidarimoghadam, R; Helms, K; Hengphasatporn, K; Henry, D; Herrmann, TRW; Hesson, T; Himmelbauer, MK; Hindle, A; Hoffmann, R; Hogg, N; Hong, KB; Hong, SK; Honjol, Y; Hood, C; Hsi, RS; Hsu, JL; Hu, B; Hu, BC; Hu, D; Hu, H; Hu, J; Hu, K; Hu, M; Hu, MK; Hu, T; Hu, W; Hu, Y; Hu, Z; Hua, S; Huang, H; Huang, J; Huang, L; Huang, M; Huang, P; Huang, X; Huang, Y; Huang, Z; Hukkanen, J; Hung, MC; Huo, X; Hyötyläinen, T; Ianiro, G; Ibanez, B; Imran, M; Ireland, S; Irwin, MS; Ishiguro, H; Jackowski, K; Jackson, C; Jacob, SI; Jahromy, MH; Jakob, SM; Jang, J; Javvaji, PK; Jefferson, KK; Jena, P; Ji, H; Jiang, F; Jiang, GH; Jiang, H; Jiang, J; Jiang, X; Jiang, Z; Jiao, J; Jiménez, A; Jin, X; Jincai, W; Jintao, X; Jo, K; Jofra, T; Johari, Y; Johnson, ACM; Jones, JH; Josephine Fauci, A; Juhl, AK; Jun, S; Kaiser, RI; Kajioka, J; Kajiyama, H; Kalliyil, A; Kalthur, SG; Kamalanathan, M; Kamaldinov, T; Kanaani, L; Kang, D; Kang, J; Kang, S; Känsäkoski, P; Kaplan, DL; Karwan, M; Kasibhatla, S; Kaur, A; Kawazoe, Y; Ke, C; Keyser, J; Khalique, A; Khan, IT; Kharshoum, RM; Kher, R; Kherani, J; Ki, KK; Kikkawa, F; Kikkawa, R; Kim, BT; Kim, EH; Kim, GA; Kim, GD; Kim, HB; Kim, HG; Kim, JS; Kim, MJ; Kim, SI; Kim, SJ; Kim, Y; King, K; Kinyamu-Akunda, J; Kirkkala, T; Kjaer-Sorensen, K; Kleppinger, EL; Kloner, RA; Klopfenstein, TJ; Knappe, D; Knezevic, P; Kobos, LM; Kohli, M; Kolano, L; Kolodgie, FD; Kolte, AP; Koneru, B; Kong, D; Kong, F; Kong, X; Konggidinata, MI; Köpke, M; Koski, KG; Kotsis, F; Köttgen, A; Kouakou-Kouamé, CA; Kraemer, US; Krane, V; Krehbiel, CR; Krenning, BJ; Kretzschmar, D; Ku, KB; Kubota, Y; Kulich, P; Kumar, NG; Kupiec-Weglinski, JW; Lalani, SS; Lan, X; Landfeldt, E; Langenberg, E; Lapauw, B; Larkin, J; Lassoued, MA; Laukhtina, E; Laura Martinez, J; Laveillé, A; Lavela, P; Law, AD; Lazraq, A; Le Foll, B; Lee, BK; Lee, C; Lee, CS; Lee, EJ; Lee, EY; Lee, G; Lee, HY; Lee, JH; Lee, JJ; Lee, JO; Lee, JS; Lee, R; Lei, H; Lei, P; Lellouche, F; Lennerz, JK; Leong, W; Leslie, I; Lessem, E; Levin, M; Levinger, I; Li, C; Li, CW; Li, CX; Li, CY; Li, D; Li, H; Li, HM; Li, J; Li, L; Li, LM; Li, N; Li, S; Li, W; Li, X; Li, XX; Li, Y; Li, Z; Li, ZL; Li, ZX; Lian, Q; Liang, C; Liang, GH; Liang, H; Liang, J; Liang, X; Liao, CX; Liao, R; Ličbinský, R; Lim, YS; Lima, HK; Lin, JG; Lin, L; Lin, S; Lin, WP; Lin, Z; Liso, M; Liu, BX; Liu, C; Liu, H; Liu, J; Liu, M; Liu, Q; Liu, S; Liu, SF; Liu, SL; Liu, T; Liu, W; Liu, X; Liu, XB; Liu, Y; Liu, YY; Liu, Z; Liu, ZQ; Lobo, M; Loitzenbauer, M; López, F; Lopez, G; López, GJ; Lou, Z; Lu, IC; Lu, J; Lu, M; Lu, W; Lu, X; Lu, Y; Luhovyy, BL; Luna-Abanto, J; Luo, J; Luo, K; Luo, L; Luo, M; Luo, W; Luo, X; Luo, XM; Lv, Y; Lv, YQ; Lyu, HD; Lyu, J; Ma, C; Ma, G; Ma, L; Ma, Q; Ma, X; Ma, Y; Macha, SJ; MacLean, E; Mahalapbutr, P; Maina, T; Malfait, F; Malfertheiner, MV; Malzert-Fréon, A; Mansouri, E; Mao, C; Marcellin, E; Marchiori, PER; Marcotte, DJ; Maréchal, A; Maric, N; Maris, JM; Maron, L; Marti, CN; Martínez-Milla, J; Mateo, J; Mather, K; Mathison, CJN; Matthay, MA; Maxwell, CL; Mazier, D; Mazumder, D; Mazurkiewicz, M; Mazzucchelli, TG; McAuley, DF; Mccoy, K; McVicar, DW; Mebel, AM; Mech, A; Meester, EJ; Meiselbach, H; Melero, I; Ménard, G; Meng, X; Mengya, Y; Merle, G; Meunier, B; Mfarrej, B; Mi, K; Migueliz, I; Mikuška, P; Miladi, K; Miletich, R; Millar, JE; Mills, MR; Milne, R; Minute, L; Misiak, M; Mo, F; Modi, A; Mok, F; Molina, C; Mollen, CJ; Molteni, V; Montalto, M; Montet, D; Monti, MC; Moor, MB; Moravec, P; Morsiani, C; Murillo, E; Murugan, P; Muslem, R; Myers, RK; N'guessan, FK; Nabil, H; Nadal, J; Nadeem, M; Nafady, MM; Nafie, MS; Nair, HP; Nakano, R; Nance, J; Naren, N; Neil, CJ; Nelson, J; Nery, FC; Netsch, C; Nguyen, TH; Ni, L; Ni, YX; Nie, W; Nielsen, LK; Nigam, K; Nikolayev, AA; Nishiyama, M; Niu, LL; Niu, PP; Nock, BA; Noer, PR; Noll, G; Noll, S; Norenberg, JP; Nowicka, J; Nutho, B; O'Connor, M; Obonyo, NG; Ochiai, T; Ochoa, MC; Oh, BL; Oh, S; Olczak, J; Olivares, X; Ommurugan, B; Oosthuizen, MC; Operario, D; Orešič, M; Oshima, K; Otano, I; Ou, Y; Owen, TW; Oxvig, C; Pacey, V; Pai, M; Paik, H; Paiva, R; Palmieri, EM; Palpant, N; Pan, L; Pan, Q; Panahi, S; Pang, B; Pang, ZC; Pannecouque, C; Paris, L; Park, D; Park, DJ; Park, E; Park, EC; Park, IH; Park, JH; Park, JI; Park, S; Passmore, MR; Pattaranggoon, NC; Paun, M; Pedersen, S; Pedron, J; Peng, M; Peng, X; Penzhorn, BL; Pérez-Camargo, D; Perez-Maldonado, R; Pérez-Vicente, C; Pham, TD; Pickering, L; Pickersgill, NA; Pinault, E; Pinotsis, N; Plan, M; Pocino, K; Poh, CL; Pons, EDC; Popoff, MR; Porri, D; Pourmand, A; Pratviel, G; Prudente, DO; Qi, H; Qi, N; Qian, LY; Qiao, L; Qiao, Q; Qin, QP; Qiu, N; Qiu, SW; Qu, F; Quan, M; Quigg, A; Raee, E; Raibaud, P; Ramanitrahasimbola, D; Rapoport, L; Rasby, RJ; Rasoanirina, BNV; Raspini, B; Ratner, JR; Razafindrakoto, Z; Redd, MA; Ren, H; Ren, N; Rey, J; Reynolds, CP; Rich, PR; Richards, CJ; Rigol, M; Rimoldi, S; Robert, P; Rodrigues, AE; Roe, JH; Rohde, S; Rokita, JL; Roland, J; Rombaut, L; Ronkainen, J; Rothenberg, SM; Roy, SC; Ruan, Z; Rucker, PV; Rueda, D; Ruhwald, M; Rungrotmongkol, T; Rupert, AS; Rusjan, P; Ryabov, AD; Rysä, J; Saad, NES; Sabioni, P; Sadow, PM; Sahai, N; Salem, HF; Salinas, B; Salonurmi, T; Samé Guerra, D; Sánchez, J; Sanchez-González, J; Sanmamed, MF; Sansores-Peraza, P; Santoro, JC; Santschi, PH; Saritas, T; Sarkisova, Y; Savolainen, MJ; Scherberich, JE; Schlom, DG; Schmelz, EM; Schmid, MC; Schneider, MP; Schumacher, S; Schwartz, JC; Schwartzer, JJ; Schwehr, K; Schweitzer, DH; Scott, ME; Sedky, NK; See Hoe, L; Sejian, V; Selvaraju, S; Sen, SK; Seo, G; Šerý, O; Settles, JA; Sfar, S; Shaffer, J; Shan, GL; Shang, Q; Shannahan, JH; Shao, B; Shao, H; 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| Colemen, ER; Dunbar, JC; Marzouq, L; Shaffer, LR | 1 |
| Kawai, K; Murayama, Y; Suzuki, S; Watanabe, Y; Yamashita, K | 1 |
| Hirata, Y; Inoue, Y; Matsumoto, H; Mochizuki, N; Tasaka, Y | 1 |
| Bailbe, D; Blivet, MJ; Capeau, J; Caron, M; Cherqui, G; Melin, B; Picard, J; Portha, B | 1 |
| Martin, M; Nadeau, A; Plourde, G; Rousseau-Migneron, S | 1 |
| Goshima, K; Iguchi, A; Ishiguro, T; Kunoh, Y; Miura, H; Mizuno, S; Sakamoto, N; Tamagawa, T; Uemura, K | 1 |
| Lee, G; Shah, PR; Widmaier, EP | 1 |
| Houslay, MD; Palmer, TM | 1 |
| Müller, MK; von Schönfeld, J | 1 |
| Efendic, S; Jokay, M; Lickley, L; Rastogi, KS; Vranic, M | 1 |
| Mandel, TE; Thompson, SC | 1 |
| Iwashima, Y; Makino, I; Watanabe, K | 1 |
| Efendic, S; Grill, V; Ostenson, CG | 1 |
| Kawagishi, T | 1 |
| Gagliardino, JJ; Gómez Dumm, CL; Semino, MC | 1 |
| Iguchi, A; Miura, H; Sakamoto, N; Tamagawa, T; Uemura, K; Yatomi, A | 1 |
| Brubaker, PL; Roberge, JN | 1 |
| de Boer, SF; Frölich, M; Koopmans, SJ; Krans, HM; Radder, JK; Sips, HC | 1 |
| Almdal, TP | 1 |
| Duys, S; Pipeleers, DG; Pipeleers-Marichal, M; Vanbrabandt, B | 1 |
| Aerts, L; Holemans, K; Van Assche, FA | 1 |
| Blech, W; Blume, R; Brömme, HJ; Cossel, L; Hahn, HJ; Hildebrandt, W; Wohlrab, F | 1 |
| Cattral, MC; Jaspan, JL; Kneteman, NM; Rajotte, RV; Scharp, DW; Warnock, GL | 1 |
| Bretzel, RG; Federlin, K; Planck, H; Renardy, M; Siebers, U; Zekorn, T; Zschocke, P | 1 |
| Blázquez, E; Muñoz-Barragán, L | 1 |
| Khandelwal, RL; Pugazhenthi, S | 1 |
| Ferrannini, E; Lanfranchi, A; Manfredini, G; Rohner-Jeanrenaud, F; Van de Werve, G | 1 |
| Kawai, K; Mukai, H; Murayama, Y; Ohashi, S; Suzuki, S; Yamashita, K | 1 |
| Fält, K; Hehmke, B; Kohnert, KD; Odselius, R; Ziegler, B; Ziegler, M | 1 |
| Cánepa, ET; Grinstein, M; Llambías, EB | 1 |
| Bell, RH; Fisher, WE; McCullough, PJ; Rämö, OJ | 1 |
| Danis, EH; Goodman, AD; Hoekstra, S; Monahan, JW | 1 |
| Chiou, GC; Shen, ZF; Zheng, YQ | 1 |
| Chesta, J; Debnam, ES; Epstein, O; Srai, SK | 1 |
| Kanamoto, R; Miller, DA; Ogawa, H; Pitot, HC; Su, Y | 1 |
| Bonner-Weir, S; Leahy, JL; Weir, GC | 2 |
| Inoue, H; Noguchi, T; Tanaka, T | 1 |
| Ohki, A; Okabayashi, Y; Otsuki, M; Sakamoto, C | 1 |
| Cortes, P; Dumler, F; Goldman, J; Levin, NW | 1 |
| Connell, CL; Connell, MA; Diani, AR; Hannah, BA; Jodelis, KS; Sawada, GA; Vidmar, TJ; Wyse, BM | 1 |
| Duan, RD; Erlanson-Albertsson, C | 1 |
| Gawler, DJ; Houslay, MD; Milligan, G; Murphy, GJ; Pyne, NJ; Wakelam, MJ | 1 |
| Ariño, J; Bosch, F; Gómez-Foix, AM; Guinovart, JJ; Rodríguez-Gil, JE | 1 |
| Blackmore, PF; Exton, JH; Johnson, EH; Krone, PK; Lynch, CJ; Wange, RL | 1 |
| Bretzel, RG; Cohen, AM; Federlin, K; Wiegand, S | 1 |
| Kawai, K; Ohmori, H; Yamashita, K | 1 |
| Blech, W; Brömme, HJ; Hahn, HJ; Hildebrandt, W; Lucke, S | 1 |
| Ahrén, B; Alumets, J; Ar'Rajab, A; Bengmark, S | 1 |
| Ahrén, B; Ar'Rajab, A; Bengmark, S | 1 |
| Fujishima, M; Iwase, M; Kikuchi, M; Kodama, T; Maki, Y; Nunoi, K; Sadoshima, S | 1 |
| Baba, S; Ohki, A; Okabayashi, Y; Otsuki, M; Tani, S | 1 |
| Blech, W; Blume, R; Brömme, HJ; Hahn, HJ; Hildebrandt, W; Kohnert, KD | 1 |
| Alvarez, E; Blázquez, E; de Diego, JG; Mellado, C; Rodríguez, V | 1 |
| Ganas, L; Studer, RK | 1 |
| Bhathena, SJ; Carswell, N; Hansen, CT; Jones, J; Kennedy, BW; Michaelis, OE; Recant, L; Smith, PM; Voyles, NR | 1 |
| Irie, M; Kajinuma, H; Sato, N; Suzuki, K | 1 |
| Gawler, DJ; Houslay, MD; Milligan, G; Wilson, A | 1 |
| Foltzer, C; Harvey, S; Karmann, H; Laurent, F; Mialhe, P | 1 |
| Bouillon, R; Peeters, TL; Rombauts, W; Van Assche, FA; Vandeputte, M; Verhaeghe, J | 1 |
| Mezzogiorno, V; Papaccio, G | 1 |
| Boström, M; Goertz, G; Henriksson, J; Nie, Z; Wallberg-Henriksson, H | 1 |
| Arata, M; Basabe, JC; Karabatas, LM; Pivetta, OH | 1 |
| Alam, T; Chen, L; Inman, L; Komiya, I; McCorkle, K; Unger, RH | 1 |
| Byers, M; Gauthier, C; Hetenyi, G; Vranic, M | 1 |
| Berk, M; Clark, KE; Mimouni, F; Miodovnik, M | 1 |
| Goto, M; Inoue, H; Inoue, O; Seyama, Y; Yamashita, S; Yumioka, E | 1 |
| Epstein, PN; Means, AR; Overbeek, PA | 1 |
| Altszuler, N; Bowden, CR; Inman, M; Tuman, RW; Tutwiler, GF | 1 |
| Bertrand, G; Gross, R; Hillaire-Buys, D; Loubatieres-Mariani, MM; Ribes, G | 1 |
| Sanda, M | 1 |
| Baudon, MA; Castano, L; Ferré, P; Girard, J; Ktorza, A; Maulard, P; Pénicaud, L | 1 |
| Dunbar, JC; Houser, F; Schultz, S; Walker, J | 1 |
| Wimmer, M | 1 |
| Patel, DG; Skau, KA | 1 |
| Brubaker, PL; Drucker, DJ; So, DC | 1 |
| Bloom, SR; Burnet, P; Diani, AR; Ghatei, MA; Kanse, S; Kreymann, B; Williams, G | 1 |
| Calle, C; Mayor, P | 1 |
| Hermansen, K; Orskov, H; Schmitz, O | 1 |
| Leahy, JL; Weir, GC | 1 |
| Christova, T; Daskalova, R | 1 |
| Hermansen, K; Mogensen, CE; Schmitz, O | 1 |
| Akao, Y; Hirata, Y; Inoue, Y; Marumo, K; Mizuno, Y; Tasaka, Y | 1 |
| Lickley, HL; Vranic, M; Wasserman, DH | 2 |
| Elliott, RB; Reddy, SN | 1 |
| Pipeleers, D | 1 |
| Baccou, JC; Da Costa, C; Loubatieres-Mariani, MM; Ribes, G; Sauvaire, Y | 1 |
| Vranic, M; Wasserman, DH | 1 |
| Eto, M; Ishii, K; Iwashima, Y; Morikawa, A; Takebe, T; Watanabe, K | 1 |
| Bray, GA; Caple, MV; Ohshima, K; Spear, GS | 1 |
| Imamura, T; Starke, A; Unger, RH | 1 |
| Asakura, T; Fujimoto, K; Ichio, T; Kozuka, Y; Maekawa, T; Murata, K; Tanaka, Y; Toyota, N; Yamamoto, T; Yoshimura, K | 1 |
| Karmann, H; Laurent, F; Mialhe, P | 1 |
| el-Tayeb, KM; Kemmer, FW; Lickley, HL; Vranic, M | 1 |
| Bunag, R; Doull, V; Kimmel, JR; Sasaki, S; Tomita, T | 1 |
| Carloni, C; Cristallini, S; Filipponi, P; Gregorio, F; Gubbiotti, G; Pippi, R | 1 |
| Brown, RA; Duguid, WP; Rosenberg, L; Vinik, AI | 1 |
| Chenon, D; Gross, R; Loubatières-Mariani, MM; Ribes, G | 1 |
| White, MF | 1 |
| Leroux, JP; Rouer, E; Rouet, P | 1 |
| Brubaker, PL; el-Tayeb, KM; Lickley, HL; Vranic, M | 1 |
| Bauman, A; Jeffrey, J; Jonasson, O; Jones, C; Lands, W; Takimoto, G | 1 |
| Blayac, JP; Loubatières-Mariani, MM; Ribes, G; Zerbib, A | 1 |
| Besmond, C; Darquy, S; Dreyfus, JC; Kahn, A; Munnich, A; Reach, G; Vaulont, S | 1 |
| Jungermann, K; Miethke, H; Nath, A; Wittig, B; Zierz, S | 1 |
| Bihoreau, MT; Girard, J; Ktorza, A; Nurjhan, N; Picon, L | 1 |
| Kawai, K; Okuda, Y; Yamashita, K | 1 |
| Kahn, A; Lyonnet, S; Munnich, A; Ogier, H; Reach, G; Vaulont, S | 1 |
| Ramanadham, S; Tenner, TE | 1 |
| Gysin, B; Hruby, VJ; Johnson, DG; Trivedi, D | 1 |
| Chambers, LL; Chirtel, SJ; Ekarohita, N; Lakshman, MR | 1 |
| Hirata, Y; Inoue, Y; Matsumoto, H; Tasaka, Y | 1 |
| Ikeda, J; Ito, H; Kanazawa, M; Kanazawa, Y; Kawazu, S; Komeda, K; Natoya, Y; Sato, J | 1 |
| Hashigami, Y; Kobori, H; Ohtake, R; Shimoda, SI; Suzuki, H; Suzuki, Y | 1 |
| Besch, W; Hartmann, K; Herrmann, I; Keilacker, H; Voss, C; Zühlke, H | 1 |
| Almdal, TP; Vilstrup, H | 3 |
| Howard, CF | 1 |
| Albisser, AM; Greenberg, GR; McPhedran, NT; Nomura, M | 1 |
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| Efendić, S; Grill, V; Gutniak, M; Nylén, A; Ostenson, CG | 1 |
| Gawler, D; Houslay, MD; Milligan, G | 1 |
| Benoit, JN; Granger, DN; Korthuis, RJ; Smith, JK; Yrle, LF | 1 |
| Bloom, SR; Ghatei, MA; Kanse, S; Kreymann, B; Williams, G; Yiangou, Y | 1 |
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| Kitamura, J | 1 |
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| Khandelwal, RL; Roesler, WJ | 1 |
| Cherrington, AD; Stevenson, RW; Williams, PE | 1 |
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| Bonnevie-Nielsen, V | 1 |
| Koopmans, HS; Xavier Pi-Sunyer, F | 1 |
| Baetens, D; Maruyama, H; Orci, L; Tominaga, M; Unger, RH; Vasko, MR | 1 |
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| Almdal, TP; Hansen, BA; Petersen, KF; Vilstrup, H | 1 |
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| Ornoy, A; Yaffe, P; Zusman, I | 1 |
| Besch, W; Hahn, HJ; Klöting, I; Ziegler, B; Ziegler, M | 1 |
| Grantham, BD; Zammit, VA | 1 |
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| Hatta, S | 1 |
| Bate, AJ; Fisher, MJ; Pogson, CI; Santana, MA | 1 |
| Eriksson, UJ; Hellerström, C; Swenne, I | 1 |
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| Jobidon, C; Nadeau, A; Rousseau-Migneron, S; Tancrède, G; Trudel, D | 1 |
| Cros, GH; McNeill, JH; Michel, A; Serrano, JJ | 1 |
| Dalstein, JM; Loubatieres-Mariani, MM; Ribes, G; Valette, G | 1 |
| Augereau, C; Beaune, P; Leroux, JP; Rouer, E | 1 |
| Anand-Srivastava, MB; Srivastava, AK | 1 |
| Kikuchi, G; Kim, HJ | 1 |
| Voskresenskiĭ, ON | 1 |
| Braun, P; Fóris, G; Gedeon, A; Kertai, P | 1 |
| Bitensky, MW; Gorman, RE; Neufeld, AH | 1 |
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| Exton, JH; Park, CR | 1 |
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| Friedmann, B; Goodman, EH; Weinhouse, S | 1 |
| Exton, JH; Friedmann, N; Jefferson, LS; Mallette, LE; Park, CR; Wong, EH | 1 |
| Exton, JH; Friedmann, N; Jefferson, LS; Mallette, LE; Miller, TB; Park, CR; Wong, EH | 1 |
| Rawat, AK | 1 |
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| Harper, AE; Lee, SC; Morris, ML | 1 |
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| Exton, JH; Harper, SC; Ho, RJ; Tucker, AL | 1 |
| Exton, JH; Johnson, RA; Park, CR; Pilkis, SJ | 1 |
| Blake, DA; Buterbaugh, GG; Weiner, M | 1 |
| Clark, JB; Greenbaum, AL; McLean, P | 1 |
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| Faloona, GR; Rocha, DM; Santeusanio, F; Unger, RH | 1 |
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| Alcántara, A; Clemente, F; López-Delgado, MI; Luque, MA; Malaisse, WJ; Márquez, L; Morales, M; Puente, J; Valverde, I; Villanueva-Peñacarrillo, ML; Viñambres, C | 1 |
53 review(s) available for glucagon and Alloxan Diabetes
| Article | Year |
|---|---|
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor Proteins, Signal Transducing; Adenine; Adenocarcinoma; Adipogenesis; Administration, Cutaneous; Administration, Ophthalmic; Adolescent; Adsorption; Adult; Aeromonas hydrophila; Aerosols; Aged; Aged, 80 and over; Aging; Agriculture; Air Pollutants; Air Pollution; Airway Remodeling; Alanine Transaminase; Albuminuria; Aldehyde Dehydrogenase 1 Family; Algorithms; AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase; Alzheimer Disease; Amino Acid Sequence; Ammonia; Ammonium Compounds; Anaerobiosis; Anesthetics, Dissociative; Anesthetics, Inhalation; Animals; Anti-Bacterial Agents; Anti-HIV Agents; Anti-Infective Agents; Anti-Inflammatory Agents; Antibiotics, Antineoplastic; Antibodies, Antineutrophil Cytoplasmic; Antibodies, Monoclonal, Humanized; Antifungal Agents; Antigens, Bacterial; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Antitubercular Agents; Antiviral Agents; Apolipoproteins E; Apoptosis; Arabidopsis; Arabidopsis Proteins; Arsenic; Arthritis, Rheumatoid; Asthma; Atherosclerosis; ATP-Dependent Proteases; Attitude of Health Personnel; Australia; Austria; Autophagy; Axitinib; Bacteria; Bacterial Outer Membrane Proteins; Bacterial Proteins; Bacterial Toxins; Bacterial Typing Techniques; Bariatric Surgery; Base Composition; Bayes Theorem; Benzoxazoles; Benzylamines; beta Catenin; Betacoronavirus; Betula; Binding Sites; Biological Availability; Biological Oxygen Demand Analysis; Biomarkers; Biomarkers, Tumor; Biopsy; Bioreactors; Biosensing Techniques; Birth Weight; Blindness; Blood Chemical Analysis; Blood Gas Analysis; Blood Glucose; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Blood-Brain Barrier; Blotting, Western; Body Mass Index; Body Weight; Bone and Bones; Bone Density; Bone Resorption; Borates; Brain; Brain Infarction; Brain Injuries, Traumatic; Brain Neoplasms; Breakfast; Breast Milk Expression; Breast Neoplasms; Bronchi; Bronchoalveolar Lavage Fluid; Buffaloes; Cadherins; Calcification, Physiologic; Calcium Compounds; Calcium, Dietary; Cannula; Caprolactam; Carbon; Carbon Dioxide; Carboplatin; Carcinogenesis; Carcinoma, Ductal; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Carcinoma, Renal Cell; Cardiovascular Diseases; Carps; Carrageenan; Case-Control Studies; Catalysis; Catalytic Domain; Cattle; CD8-Positive T-Lymphocytes; Cell Adhesion; Cell Cycle Proteins; Cell Death; Cell Differentiation; Cell Line; Cell Line, Tumor; Cell Movement; Cell Nucleus; Cell Phone Use; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cells, Cultured; Cellulose; Chemical Phenomena; Chemoradiotherapy; Child; Child Development; Child, Preschool; China; Chitosan; Chlorocebus aethiops; Cholecalciferol; Chromatography, Liquid; Circadian Clocks; Circadian Rhythm; Circular Dichroism; Cisplatin; Citric Acid; Clinical Competence; Clinical Laboratory Techniques; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Clostridioides difficile; Clostridium Infections; Coculture Techniques; Cohort Studies; Cold Temperature; Colitis; Collagen Type I; Collagen Type I, alpha 1 Chain; Collagen Type XI; Color; Connective Tissue Diseases; Copper; Coronary Angiography; Coronavirus 3C Proteases; Coronavirus Infections; Cost of Illness; Counselors; COVID-19; COVID-19 Testing; Creatine Kinase; Creatinine; Cross-Over Studies; Cross-Sectional Studies; Cryoelectron Microscopy; Cryosurgery; Crystallography, X-Ray; Cues; Cultural Competency; Cultural Diversity; Curriculum; Cyclic AMP Response Element-Binding Protein; Cyclin-Dependent Kinase Inhibitor p21; Cycloparaffins; Cysteine Endopeptidases; Cytokines; Cytoplasm; Cytoprotection; Databases, Factual; Denitrification; Deoxycytidine; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diagnosis, Differential; Diatoms; Diet; Diet, High-Fat; Dietary Exposure; Diffusion Magnetic Resonance Imaging; Diketopiperazines; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Disease Progression; Disease-Free Survival; DNA; DNA Damage; DNA Glycosylases; DNA Repair; DNA-Binding Proteins; DNA, Bacterial; DNA, Viral; Docetaxel; Dose Fractionation, Radiation; Dose-Response Relationship, Drug; Down-Regulation; Doxorubicin; Drosophila; Drosophila melanogaster; Drug Carriers; Drug Delivery Systems; Drug Liberation; Drug Repositioning; Drug Resistance, Bacterial; Drug Resistance, Multiple, Bacterial; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Drug Therapy, Combination; Edema; Edible Grain; Education, Graduate; Education, Medical, Graduate; Education, Pharmacy; Ehlers-Danlos Syndrome; Electron Transport Complex III; Electron Transport Complex IV; Electronic Nicotine Delivery Systems; Emergency Service, Hospital; Empathy; Emulsions; Endothelial Cells; Endurance Training; Energy Intake; Enterovirus A, Human; Environment; Environmental Monitoring; Enzyme Assays; Enzyme Inhibitors; Epithelial Cells; Epithelial-Mesenchymal Transition; Epoxide Hydrolases; Epoxy Compounds; Erythrocyte Count; Erythrocytes; Escherichia coli; Escherichia coli Infections; Escherichia coli Proteins; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Esophagectomy; Estrogens; Etanercept; Ethiopia; Ethnicity; Ethylenes; Exanthema; Exercise; Exercise Test; Exercise Tolerance; Extracellular Matrix; Extracorporeal Membrane Oxygenation; Eye Infections, Fungal; False Negative Reactions; Fatty Acids; Fecal Microbiota Transplantation; Feces; Female; Femur Neck; Fermentation; Ferritins; Fetal Development; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Fibroblasts; Fibroins; Fish Proteins; Flavanones; Flavonoids; Focus Groups; Follow-Up Studies; Food Handling; Food Supply; Food, Formulated; Forced Expiratory Volume; Forests; Fractures, Bone; Fruit and Vegetable Juices; Fusobacteria; G1 Phase Cell Cycle Checkpoints; G2 Phase Cell Cycle Checkpoints; Gamma Rays; Gastrectomy; Gastrointestinal Microbiome; Gastrointestinal Stromal Tumors; Gefitinib; Gels; Gemcitabine; Gene Amplification; Gene Expression; Gene Expression Regulation; Gene Expression Regulation, Bacterial; Gene Expression Regulation, Neoplastic; Gene Expression Regulation, Plant; Gene Knockdown Techniques; Gene-Environment Interaction; Genotype; Germany; Glioma; Glomerular Filtration Rate; Glucagon; Glucocorticoids; Glycemic Control; Glycerol; Glycogen Synthase Kinase 3 beta; Glycolipids; Glycolysis; Goblet Cells; Gram-Negative Bacterial Infections; Granulocyte Colony-Stimulating Factor; Graphite; Greenhouse Effect; Guanidines; Haemophilus influenzae; HCT116 Cells; Health Knowledge, Attitudes, Practice; Health Personnel; Health Services Accessibility; Health Services Needs and Demand; Health Status Disparities; Healthy Volunteers; 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STAT3 Transcription Factor; Streptomyces coelicolor; Stress, Psychological; Stroke; Stroke Volume; Structure-Activity Relationship; Students, Medical; Students, Pharmacy; Substance Abuse Treatment Centers; Sulfur Dioxide; Surface Properties; Surface-Active Agents; Surveys and Questionnaires; Survival Analysis; Survival Rate; Survivin; Sweden; Swine; Swine, Miniature; Sympathetic Nervous System; T-Lymphocytes, Regulatory; Talaromyces; Tandem Mass Spectrometry; tau Proteins; Telemedicine; Telomerase; Telomere; Telomere Homeostasis; Temperature; Terminally Ill; Th1 Cells; Thiamethoxam; Thiazoles; Thiophenes; Thioredoxin Reductase 1; Thrombosis; Thulium; Thyroid Cancer, Papillary; Thyroid Carcinoma, Anaplastic; Thyroid Neoplasms; Time Factors; Titanium; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed; TOR Serine-Threonine Kinases; Transcription Factor AP-1; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transcriptome; Transforming Growth Factor beta1; Transistors, Electronic; Translational Research, Biomedical; Transplantation Tolerance; Transplantation, Homologous; Transportation; Treatment Outcome; Tretinoin; Tuberculosis, Multidrug-Resistant; Tuberculosis, Pulmonary; Tubulin Modulators; Tumor Microenvironment; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha; Twins; Ultrasonic Therapy; Ultrasonography; Ultraviolet Rays; United States; Up-Regulation; Uranium; Urethra; Urinary Bladder; Urodynamics; Uromodulin; Uveitis; Vasoconstrictor Agents; Ventricular Function, Left; Vero Cells; Vesicular Transport Proteins; Viral Nonstructural Proteins; Visual Acuity; Vital Capacity; Vitamin D; Vitamin D Deficiency; Vitamin K 2; Vitamins; Volatilization; Voriconazole; Waiting Lists; Waste Disposal, Fluid; Wastewater; Water Pollutants, Chemical; Whole Genome Sequencing; Wine; Wnt Signaling Pathway; Wound Healing; Wounds and Injuries; WW Domains; X-linked Nuclear Protein; X-Ray Diffraction; Xanthines; Xenograft Model Antitumor Assays; YAP-Signaling Proteins; Yogurt; Young Adult; Zebrafish; Zebrafish Proteins; Ziziphus | 2016 |
Insulin and Glucagon: Partners for Life.
Topics: Animals; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Experimental; Glucagon; Humans; Hypoglycemic Agents; Insulin | 2017 |
Glucagon, a key factor in the pathophysiology of type 2 diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Fasting; Glucagon; Glucose; Humans; Hyperglycemia; Liver; Rodentia | 2017 |
Experimental and clinical aspects of melatonin and clock genes in diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Glucagon; Humans; Insulin; Melatonin | 2015 |
Glucose control of glucagon secretion-'There's a brand-new gimmick every year'.
Topics: Animals; Autoimmune Diseases; Blood Glucose; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Glucagon; Glucagon-Secreting Cells; Glucose; Humans; Hyperglycemia; Insulin; Insulin-Secreting Cells; Islets of Langerhans; Mice; Signal Transduction; Somatostatin | 2016 |
Fibroblast growth factor 21: from pharmacology to physiology.
Topics: Adipose Tissue; Animals; Diabetes Mellitus; Diabetes Mellitus, Experimental; Fibroblast Growth Factors; Glucagon; Growth Substances; Humans; Insulin; Liver; Mice; Obesity; Pancreas; Primates; Rodentia; Starvation; Triglycerides; Weight Loss | 2010 |
Molecular pathways underlying the pathogenesis of pancreatic alpha-cell dysfunction.
Topics: Animals; Diabetes Mellitus, Experimental; Gene Expression Regulation; Glucagon; Glucagon-Secreting Cells; Humans; Hyperglycemia; Hypertrophy; Islets of Langerhans; Models, Biological; Nervous System; Neurotransmitter Agents; Pancreas; Signal Transduction; Somatostatin | 2010 |
Glucagon gene expression in the endocrine pancreas: the role of the transcription factor Pax6 in α-cell differentiation, glucagon biosynthesis and secretion.
Topics: Animals; Cell Differentiation; Diabetes Mellitus, Experimental; Eye Proteins; Gene Expression Regulation; Glucagon; Glucagon-Secreting Cells; Homeodomain Proteins; Mice; Paired Box Transcription Factors; PAX6 Transcription Factor; Rats; Repressor Proteins; Transcription Factors | 2011 |
Growth factor signalling in the regulation of α-cell fate.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Glucagon-Secreting Cells; Humans; Mice; Mice, Knockout; Signal Transduction | 2011 |
Regulation of glucagon secretion by incretins.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Incretins; Rats; Receptors, Glucagon | 2011 |
Regulation of glucagon secretion by glucose: paracrine, intrinsic or both?
Topics: Animals; Biological Transport; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Secreting Cells; Glucose; Humans; KATP Channels; Mice | 2011 |
Regulation of glucagon secretion by zinc: lessons from the β cell-specific Znt8 knockout mouse model.
Topics: Animals; Cation Transport Proteins; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Secreting Cells; Insulin; Insulin Secretion; Insulin-Secreting Cells; Mice; Mice, Knockout; Zinc; Zinc Transporter 8 | 2011 |
The role of dysregulated glucagon secretion in type 2 diabetes.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Fasting; Glucagon; Glucagon-Like Peptide 1; Glucagon-Secreting Cells; Humans; Hyperglycemia; Insulin-Secreting Cells; Liver; Mice | 2011 |
Metabolic impact of glucagon deficiency.
Topics: Animals; Diabetes Mellitus, Experimental; Glucagon; Glucagon-Secreting Cells; Mice; Mice, Knockout; Proprotein Convertase 2; Receptors, Glucagon | 2011 |
Optimizing reduction in basal hyperglucagonaemia to repair defective glucagon counterregulation in insulin deficiency.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Secreting Cells; Hypoglycemia; Insulin; Insulin-Secreting Cells; Postprandial Period | 2011 |
Alpha cells come of age.
Topics: Animals; Cell Dedifferentiation; Cell Lineage; Cell Transdifferentiation; Diabetes Mellitus, Experimental; Enteroendocrine Cells; Epithelial-Mesenchymal Transition; Glucagon; Glucagon-Like Peptide 1; Glucagon-Secreting Cells; Homeodomain Proteins; Humans; Hyperplasia; Insulin-Secreting Cells; Islets of Langerhans; Mice; Paired Box Transcription Factors; Proprotein Convertase 1; Signal Transduction; Transcription Factors | 2013 |
EXPERIMENTAL DIABETES AND THE MODE OF ACTION OF THE SULFONYLUREAS. WITH SOME SPECULATIONS ON THE PREVENTION OF DIABETES.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Animals; Cortisone; Diabetes Mellitus; Diabetes Mellitus, Experimental; Fatty Acids; Fluoroacetates; Genetics, Medical; Glucagon; Glucose Tolerance Test; Humans; Hyperglycemia; Hypoglycemic Agents; Leucine; Pharmacology; Pregnancy; Prolactin; Rats; Research; Sulfonylurea Compounds; Tolbutamide | 1964 |
[MORPHOLOGICAL PROBLEMS IN DIABETES RESEARCH].
Topics: Adolescent; Animals; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Glucagon; Humans; Hyperglycemia; Hypoglycemic Agents; Insulin; Islands; Islets of Langerhans; Obesity; Pathology; Research | 1964 |
Pharmacology of exenatide (synthetic exendin-4): a potential therapeutic for improved glycemic control of type 2 diabetes.
Topics: Amino Acid Sequence; Animals; Cell Division; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Exenatide; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Molecular Sequence Data; Nutritional Physiological Phenomena; Peptide Fragments; Peptides; Protein Precursors; Receptors, Glucagon; Venoms | 2004 |
[Future targets in the treatment of type 2 diabetes].
Topics: Animals; Clinical Trials as Topic; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Forecasting; Glucagon; Glucagon-Like Peptide 1; Glucose; Glycated Hemoglobin; Glycogen Synthase Kinase 3; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Lipid Peroxidation; Metabolic Syndrome; Mice; Oxazines; Peptide Fragments; Phenylpropionates; Protein Precursors; Rats; Receptor, Insulin; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Signal Transduction; Thiazolidinediones; Transcription Factors | 2004 |
Treatment of type 2 diabetes mellitus with agonists of the GLP-1 receptor or DPP-IV inhibitors.
Topics: Adenosine Deaminase; Adenosine Deaminase Inhibitors; Afferent Pathways; Animals; Appetite; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Drug Therapy, Combination; Exenatide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glycoproteins; Humans; Hypoglycemic Agents; Hypothalamus; Insulin; Insulin Secretion; Intestinal Mucosa; Islets of Langerhans; Liraglutide; Lizards; Maleimides; Mice; Mice, Knockout; Mice, Obese; Peptide Fragments; Peptides; Proglucagon; Protein Precursors; Rats; Rats, Zucker; Receptors, Glucagon; Venoms | 2004 |
Body energy balance and food intake: a neuroendocrine regulatory mechanism.
Topics: Animals; Behavior; Diabetes Mellitus, Experimental; Eating; Energy Intake; Energy Metabolism; Food Deprivation; Glucagon; Glucose; Humans; Hunger; Hypothalamus; Insulin; Lipid Metabolism; Neurotransmitter Agents; Time Factors | 1983 |
On the pathogenesis of the increased glomerular filtration rate in short-term insulin-dependent diabetes.
Topics: Adult; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Female; Glomerular Filtration Rate; Glucagon; Growth Hormone; Humans; Insulin; Kidney; Male; Rats; Renal Circulation; Time Factors | 1984 |
The alimentary canal, liver and vagus play a role in short-term feeding: but is the role regulation, correlation, glucostasis or spurious association?
Topics: Animals; Cholecystokinin; Deoxyglucose; Diabetes Mellitus, Experimental; Eating; Feeding Behavior; Glucagon; Insulin; Liver Glycogen; Rabbits; Rats; Tolbutamide; Vagus Nerve | 1984 |
Diabetes in birds.
Topics: Amino Acids; Animals; Birds; Blood Glucose; Diabetes Mellitus, Experimental; Ducks; Feedback; Geese; Glucagon; Insulin; Lipid Metabolism; Pancreatectomy; Pancreatic Hormones; Pituitary Gland, Anterior | 1980 |
Systemic delivery of polypeptide drugs through ocular route.
Topics: Absorption; Administration, Topical; Animals; Diabetes Mellitus, Experimental; Eye; Glucagon; Humans; Hypoglycemia; Insulin; Ophthalmic Solutions; Peptides; Polyethylene Glycols | 1994 |
The multifaceted potential of glucagon-like peptide-1 as a therapeutic agent.
Topics: Animals; Blood Glucose; Clinical Trials as Topic; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Drug Administration Routes; Gastric Emptying; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Insulin Secretion; Intestine, Small; Islets of Langerhans; Peptide Fragments; Protein Precursors; Rats; Receptors, Glucagon; Satiety Response; Signal Transduction | 2002 |
Glucagon and diabetes.
Topics: Animals; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Disease Models, Animal; Glucagon; Humans; Molecular Weight; Streptozocin | 1977 |
Critical evaluation of methods used for the isolation of rat liver hepatocytes for metabolic studies.
Topics: Animals; Cell Separation; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Glucagon; Glycogen; Hyaluronoglucosaminidase; Insulin; Liver; Microbial Collagenase; Protein Biosynthesis; Rats | 1975 |
Glucagon and diabetes mellitus.
Topics: Animals; Diabetes Mellitus; Diabetes Mellitus, Experimental; Glucagon; Humans; Insulin; Islets of Langerhans; Pancreas; Prediabetic State; Somatostatin | 1979 |
Regulation of gluconeogenesis by glucocorticoids.
Topics: Adrenalectomy; Animals; Diabetes Mellitus, Experimental; Epinephrine; Glucagon; Glucocorticoids; Gluconeogenesis; Hydrocortisone; Liver; Rats | 1979 |
Somatostatin--another pancreatic islet hormone.
Topics: Animals; Diabetes Mellitus; Diabetes Mellitus, Experimental; Glucagon; Humans; Immunoassay; Insulin; Islets of Langerhans; Somatostatin; Species Specificity | 1979 |
Etiologic, pathophysiologic and clinical interrelationships in diabetes.
Topics: Animals; Autoimmune Diseases; Coxsackievirus Infections; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetic Angiopathies; Glucagon; Glucose; Humans; Insulin; Insulin Antibodies; Insulin Secretion; Islets of Langerhans; Pancreas Transplantation; Proinsulin; Rats; Receptors, Drug; Transplantation, Homologous | 1975 |
Octreotide and diabetes: theoretical and experimental aspects.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Glucagon; Growth Hormone; Humans; Insulin Resistance; Insulin-Like Growth Factor I; Octreotide; Vascular Diseases | 1992 |
The effect of pancreastatin on endocrine and exocrine pancreas.
Topics: Animals; Chromogranin A; Diabetes Mellitus; Diabetes Mellitus, Experimental; Glucagon; Humans; Insulin; Insulin Antagonists; Islets of Langerhans; Pancreas; Pancreatic Hormones | 1991 |
Importance of glucagon for nitrogen loss in diabetes--via an accelerated hepatic conversion of amino nitrogen to urea nitrogen.
Topics: Animals; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Glucagon; Humans; Liver; Nitrogen; Urea | 1991 |
Experimental reduction of B-cell mass: implications for the pathogenesis of diabetes.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Animals, Newborn; Arginine; Blood Glucose; Cyclic AMP; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Drug Synergism; Glucagon; Glucose; Glucose Tolerance Test; Histocytochemistry; Humans; Immunologic Techniques; In Vitro Techniques; Insulin; Insulin Resistance; Insulin Secretion; Islets of Langerhans; Pancreatectomy; Rats; Rats, Inbred Strains | 1986 |
Purified islet cells in diabetes research.
Topics: Alloxan; Animals; Antigens, Surface; Cell Separation; Cells, Cultured; Cyclic AMP; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Flavin-Adenine Dinucleotide; Flow Cytometry; Glucagon; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Islets of Langerhans Transplantation; NADP; Somatostatin; Streptozocin | 1986 |
Interaction between insulin and counterregulatory hormones in control of substrate utilization in health and diabetes during exercise.
Topics: Animals; Blood Glucose; Catecholamines; Diabetes Mellitus; Diabetes Mellitus, Experimental; Dogs; Glucagon; Glucose; Glycogen; Humans; Insulin; Liver; Muscles; Physical Exertion; Somatostatin | 1986 |
The transport of cationic amino acids across the plasma membrane of mammalian cells.
Topics: Amino Acids; Animals; Arginine; Binding Sites; Biological Transport, Active; Cations; Cell Line; Cell Membrane; Cell Membrane Permeability; Diabetes Mellitus, Experimental; Glucagon; Humans; Hydrogen-Ion Concentration; Kinetics; Liver; Liver Neoplasms, Experimental; Lysine; Mammals; Models, Biological; Ornithine; Rats; Sodium; Streptozocin; Substrate Specificity; Urea | 1985 |
Insulin and glucagon during the perinatal period: secretion and metabolic effects on the liver.
Topics: Animals; Animals, Newborn; Blood Glucose; Diabetes Mellitus, Experimental; Fasting; Female; Fetal Blood; Fetus; Gestational Age; Glucagon; Gluconeogenesis; Glucose; Glycogen; Humans; In Vitro Techniques; Infant, Newborn; Insulin; Insulin Secretion; Islets of Langerhans; Liver; Pancreas; Phosphoenolpyruvate Carboxykinase (GTP); Pregnancy; Pregnancy in Diabetics; Receptor, Insulin; Receptors, Cell Surface; Receptors, Glucagon; Theophylline | 1985 |
Regulation of hepatic HMG-CoA reductase in vivo by reversible phosphorylation.
Topics: Animals; Diabetes Mellitus, Experimental; Enzyme Activation; Female; Glucagon; Hydroxymethylglutaryl CoA Reductases; Insulin; Microsomes, Liver; Phosphoproteins; Phosphorylation; Pregnancy; Protein Kinases; Rats | 1987 |
Is there an animal model for gestational diabetes?
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Disease Models, Animal; Female; Gestational Age; Glucagon; Glucose; Hydrocortisone; Insulin; Insulin Resistance; Islets of Langerhans; Mice; Pregnancy; Pregnancy in Diabetics; Progesterone; Rats | 1985 |
[Pancreatic hormones and arteriosclerosis].
Topics: Aging; Animals; Arteriosclerosis; Blood Proteins; Cholesterol; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Dogs; Fatty Acids; Fatty Liver; Glucagon; Guinea Pigs; Hypercholesterolemia; Insulin; Insulin Secretion; Lipotropic Agents; NADP; Obesity; Pancreatectomy; Phosphatidylcholines; Rabbits; Rats; Sterols; Tissue Extracts | 1967 |
The hormonal control of hepatic gluconeogenesis.
Topics: Adrenal Glands; Adrenalectomy; Alanine; Amino Acids; Animals; Carbon Isotopes; Cyclic AMP; Dexamethasone; Diabetes Mellitus; Diabetes Mellitus, Experimental; Epinephrine; Fasting; Fatty Acids; Glucagon; Gluconeogenesis; Glucose; Glycerol; Growth Hormone; Hormones; Hydrocortisone; Insulin; Insulin Antibodies; Lactates; Liver; Myocardium; Norepinephrine; Pyruvates | 1970 |
The biosynthesis and secretion of insulin.
Topics: Adenylyl Cyclases; Amino Acid Sequence; Animals; Cyclic AMP; Diabetes Mellitus, Experimental; Diet; Epinephrine; Fatty Acids; Glucagon; Glucose; Golgi Apparatus; Humans; Insulin; Insulin Secretion; Islets of Langerhans; Ketone Bodies; Pentoses; Phosphoric Diester Hydrolases; Proinsulin; Species Specificity; Streptozocin; Sulfonylurea Compounds | 1972 |
The control of glucagon secretion.
Topics: Adaptation, Physiological; Alanine; Animals; Diabetes Mellitus, Experimental; Diazoxide; Dogs; Fasting; Glucagon; Gluconeogenesis; Glucose; Humans; Insulin; Insulin Secretion; Islets of Langerhans; Nutritional Physiological Phenomena; Pancreas; Perfusion | 1972 |
Potassium and endocrine pancreatic function.
Topics: Adult; Animals; Blood Glucose; Chronic Disease; Diabetes Mellitus, Experimental; Dogs; Fasting; Female; Glucagon; Humans; Insulin; Insulin Secretion; Islets of Langerhans; Male; Perfusion; Potassium; Sodium; Uremia | 1974 |
Role of insulin in the hepatic handling of glucose.
Topics: Amino Acids; Animals; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Experimental; Dogs; Fatty Acids, Nonesterified; Glucagon; Gluconeogenesis; Glucose; Glucose Tolerance Test; Insulin; Liver | 1969 |
[Current views on the mode of action of hypoglycemic sulfonamides].
Topics: Amino Acids; Animals; Blood Glucose; Chlorpropamide; Diabetes Insipidus; Diabetes Mellitus, Experimental; Diuresis; Drug Synergism; Glucagon; Glucose; Glucose Tolerance Test; Humans; Hydrochlorothiazide; Hypoglycemic Agents; Injections, Intravenous; Insulin; Insulin Secretion; Liver; Rabbits; Rats; Sulfonamides; Tolbutamide | 1969 |
[The action of blood glucose lowering sulfonamides on liver metabolism].
Topics: Amino Acids; Animals; Blood Glucose; Carbutamide; Diabetes Mellitus, Experimental; Dogs; Glucagon; Glucose; Glycogen; Humans; Hypoglycemic Agents; In Vitro Techniques; Insulin; Liver; Liver Glycogen; Perfusion; Phosphates; Rats; Sulfonamides | 1969 |
[Enzymological study of amino acid nutrition. Physiological roles of serine dehydratase and cystathionine synthetase].
Topics: Amino Acids; Animals; Blood Glucose; Carbon Isotopes; Diabetes Mellitus, Experimental; Diet; Electrophoresis; Feedback; Glucagon; Growth; Hydro-Lyases; Immune Sera; Immunodiffusion; L-Serine Dehydratase; Liver; Liver Neoplasms; Male; Molecular Weight; Nutritional Physiological Phenomena; Rats; Spectrophotometry; Ultracentrifugation; Urea | 1971 |
Glucagon physiology and pathophysiology.
Topics: Alanine; Amino Acids; Animals; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetic Ketoacidosis; Dietary Carbohydrates; Dietary Proteins; Fasting; Glucagon; Gluconeogenesis; Glucose; Humans; Insulin; Insulin Secretion; Pancreas | 1971 |
2 trial(s) available for glucagon and Alloxan Diabetes
| Article | Year |
|---|---|
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor Proteins, Signal Transducing; Adenine; Adenocarcinoma; Adipogenesis; Administration, Cutaneous; Administration, Ophthalmic; Adolescent; Adsorption; Adult; Aeromonas hydrophila; Aerosols; Aged; Aged, 80 and over; Aging; Agriculture; Air Pollutants; Air Pollution; Airway Remodeling; Alanine Transaminase; Albuminuria; Aldehyde Dehydrogenase 1 Family; Algorithms; AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase; Alzheimer Disease; Amino Acid Sequence; Ammonia; Ammonium Compounds; Anaerobiosis; Anesthetics, Dissociative; Anesthetics, Inhalation; Animals; Anti-Bacterial Agents; Anti-HIV Agents; Anti-Infective Agents; Anti-Inflammatory Agents; Antibiotics, Antineoplastic; Antibodies, Antineutrophil Cytoplasmic; Antibodies, Monoclonal, Humanized; Antifungal Agents; Antigens, Bacterial; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Antimetabolites, Antineoplastic; Antineoplastic Agents; 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STAT3 Transcription Factor; Streptomyces coelicolor; Stress, Psychological; Stroke; Stroke Volume; Structure-Activity Relationship; Students, Medical; Students, Pharmacy; Substance Abuse Treatment Centers; Sulfur Dioxide; Surface Properties; Surface-Active Agents; Surveys and Questionnaires; Survival Analysis; Survival Rate; Survivin; Sweden; Swine; Swine, Miniature; Sympathetic Nervous System; T-Lymphocytes, Regulatory; Talaromyces; Tandem Mass Spectrometry; tau Proteins; Telemedicine; Telomerase; Telomere; Telomere Homeostasis; Temperature; Terminally Ill; Th1 Cells; Thiamethoxam; Thiazoles; Thiophenes; Thioredoxin Reductase 1; Thrombosis; Thulium; Thyroid Cancer, Papillary; Thyroid Carcinoma, Anaplastic; Thyroid Neoplasms; Time Factors; Titanium; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed; TOR Serine-Threonine Kinases; Transcription Factor AP-1; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transcriptome; Transforming Growth Factor beta1; Transistors, Electronic; Translational Research, Biomedical; Transplantation Tolerance; Transplantation, Homologous; Transportation; Treatment Outcome; Tretinoin; Tuberculosis, Multidrug-Resistant; Tuberculosis, Pulmonary; Tubulin Modulators; Tumor Microenvironment; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha; Twins; Ultrasonic Therapy; Ultrasonography; Ultraviolet Rays; United States; Up-Regulation; Uranium; Urethra; Urinary Bladder; Urodynamics; Uromodulin; Uveitis; Vasoconstrictor Agents; Ventricular Function, Left; Vero Cells; Vesicular Transport Proteins; Viral Nonstructural Proteins; Visual Acuity; Vital Capacity; Vitamin D; Vitamin D Deficiency; Vitamin K 2; Vitamins; Volatilization; Voriconazole; Waiting Lists; Waste Disposal, Fluid; Wastewater; Water Pollutants, Chemical; Whole Genome Sequencing; Wine; Wnt Signaling Pathway; Wound Healing; Wounds and Injuries; WW Domains; X-linked Nuclear Protein; X-Ray Diffraction; Xanthines; Xenograft Model Antitumor Assays; YAP-Signaling Proteins; Yogurt; Young Adult; Zebrafish; Zebrafish Proteins; Ziziphus | 2016 |
Glucagon increases circulating fibroblast growth factor 21 independently of endogenous insulin levels: a novel mechanism of glucagon-stimulated lipolysis?
Topics: 3T3-L1 Cells; Adult; Animals; Blotting, Western; Cell Differentiation; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Female; Fibroblast Growth Factors; Glucagon; Humans; Insulin; Lipolysis; Male; Mice; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction | 2013 |
914 other study(ies) available for glucagon and Alloxan Diabetes
| Article | Year |
|---|---|
Phosphoproteomics analysis of diabetic cardiomyopathy in aging-accelerated mice and effects of D-pinitol.
Topics: Aging; Animals; Apoptosis; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Disease Models, Animal; Glucagon; Heart; Inositol; Insulin; Mice; Myocardium; Phosphopeptides; Phosphorylation; Protein Interaction Maps; Proteomics; Signal Transduction | 2022 |
Misrouting of glucagon and stathmin-2 towards lysosomal system of α-cells in glucagon hypersecretion of diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Glucagon; Glucagon-Secreting Cells; Glucose; Insulin; Lysosomes; Male; Mice; Stathmin | 2022 |
Beneficial impact of Ac3IV, an AVP analogue acting specifically at V1a and V1b receptors, on diabetes islet morphology and transdifferentiation of alpha- and beta-cells.
Topics: Animals; Blood Glucose; Cell Transdifferentiation; Diabetes Mellitus, Experimental; Glucagon; Glucagon-Secreting Cells; Insulin; Insulin-Secreting Cells; Islets of Langerhans; Mice, Inbred C57BL; Mice, Transgenic; Receptors, Vasopressin; Vasopressins | 2021 |
GABA and insulin but not nicotinamide augment α- to β-cell transdifferentiation in insulin-deficient diabetic mice.
Topics: Animals; Blood Glucose; Cell Transdifferentiation; Diabetes Mellitus, Experimental; gamma-Aminobutyric Acid; Glucagon; Glucagon-Secreting Cells; Insulin; Insulin-Secreting Cells; Mice; Niacinamide; Streptozocin | 2022 |
2'-O-Methylperlatolic Acid Enhances Insulin-Regulated Blood Glucose-Lowering Effect through Insulin Receptor Signaling Pathway.
Topics: Animals; Benzoates; Blood Glucose; Depsides; Diabetes Mellitus, Experimental; Glucagon; Glucose; Insulin; Insulin Resistance; Mice; Proto-Oncogene Proteins c-akt; Receptor, Insulin; Salicylates; Signal Transduction; Streptozocin | 2022 |
The role of pancreas to improve hyperglycemia in STZ-induced diabetic rats by thiamine disulfide.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucagon; Hyperglycemia; Insulin; Male; Pancreas; Rats; Streptozocin; Thiamine | 2022 |
Beneficial metabolic effects of recurrent periods of beta-cell rest and stimulation using stable neuropeptide Y1 and glucagon-like peptide-1 receptor agonists.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucagon; Glucagon-Like Peptide-1 Receptor; Glucose; Insulin; Liraglutide; Mice; Neuropeptide Y; Neuropeptides; Peptide YY; Streptozocin; Tyrosine | 2022 |
Alpha Cell Thioredoxin-interacting Protein Deletion Improves Diabetes-associated Hyperglycemia and Hyperglucagonemia.
Topics: Animals; Blood Glucose; Carrier Proteins; Diabetes Mellitus, Experimental; Glucagon; Glucagon-Secreting Cells; Glucose; Hyperglycemia; Insulin; Insulin-Secreting Cells; Mice; Pancreatic Diseases; Streptozocin; Thioredoxins | 2022 |
γ-aminobutyric acid modulates α-cell hyperplasia but not β-cell regeneration induced by glucagon receptor antagonism in type 1 diabetic mice.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; gamma-Aminobutyric Acid; Glucagon; Hyperplasia; Insulin; Insulin-Secreting Cells; Mice; Receptors, Glucagon; Regeneration | 2023 |
Effects of artemether on pancreatic islet morphology, islet cell turnover and α-cell transdifferentiation in insulin-deficient GluCreERT2;ROSA26-eYFP diabetic mice.
Topics: Animals; Artemether; Blood Glucose; Cell Transdifferentiation; Diabetes Mellitus, Experimental; Glucagon; Insulin; Insulin-Secreting Cells; Islets of Langerhans; Mice; Streptozocin | 2022 |
Surfactin Mitigates a High-Fat Diet and Streptozotocin-Induced Type 2 Diabetes through Improving Pancreatic Dysfunction and Inhibiting Inflammatory Response.
Topics: Animals; Blood Glucose; Claudin-1; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Glucagon; Glucose; Inflammation; Insulin Resistance; Mice; Occludin; Pancreas; Pancreatic Hormones; Phosphatidylinositol 3-Kinases; Phosphatidylinositols; Proto-Oncogene Proteins c-akt; Streptozocin | 2022 |
Exposure to intrauterine diabetes and post-natal high-fat diet: Effects on the endocrine pancreas of adult rat female pups.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diet, High-Fat; Female; Glucagon; Insulin; Islets of Langerhans; Rats; Rats, Sprague-Dawley | 2022 |
Glucagon receptor blockage inhibits β-cell dedifferentiation through FoxO1.
Topics: Animals; Blood Glucose; Cell Dedifferentiation; Diabetes Mellitus, Experimental; Forkhead Box Protein O1; Glucagon; Insulin; Insulins; Mice; Mice, Knockout; Receptors, Glucagon | 2023 |
Advantages of the retroperitoneal retrocolic space as the transplant site for encapsulated xenogeneic islets.
Topics: Animals; Diabetes Mellitus, Experimental; Glucagon; Humans; Insulin; Islets of Langerhans; Islets of Langerhans Transplantation; Mice; Rats; Retroperitoneal Space; Swine; Transplantation, Heterologous | 2023 |
Restoring glutamate receptor signaling in pancreatic alpha cells rescues glucagon responses in type 1 diabetes.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Glucagon; Glucagon-Secreting Cells; Humans; Hypoglycemia; Insulin; Mice; Receptors, Glutamate | 2022 |
Glucagon Acting at the GLP-1 Receptor Contributes to β-Cell Regeneration Induced by Glucagon Receptor Antagonism in Diabetic Mice.
Topics: Animals; Antibodies, Monoclonal; Diabetes Mellitus, Experimental; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Secreting Cells; Insulin; Mice; Receptors, Glucagon; Regeneration | 2023 |
Hyperglucagonaemia in diabetes: altered amino acid metabolism triggers mTORC1 activation, which drives glucagon production.
Topics: Adult; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucagon; Glucose; Humans; Hyperglycemia; Mammals; Mechanistic Target of Rapamycin Complex 1 | 2023 |
The GLP1R Agonist Liraglutide Reduces Hyperglucagonemia Induced by the SGLT2 Inhibitor Dapagliflozin via Somatostatin Release.
Topics: Animals; Benzhydryl Compounds; Diabetes Mellitus, Experimental; Glucagon; Glucosides; Humans; Liraglutide; Male; Mice; Somatostatin | 2019 |
Dendrobium officinale polysaccharide ameliorates diabetic hepatic glucose metabolism via glucagon-mediated signaling pathways and modifying liver-glycogen structure.
Topics: Animals; Dendrobium; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Glucagon; Glucose; Glycogen; Hypoglycemic Agents; Liver; Male; Mice, Inbred C57BL; Molecular Structure; Plant Extracts; Polysaccharides; Signal Transduction; Streptozocin | 2020 |
UCP1-independent glucose-lowering effect of leptin in type 1 diabetes: only in conditions of hypoleptinemia.
Topics: Adipose Tissue, Brown; Adipose Tissue, White; Animals; Blood Glucose; Corticosterone; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Disease Models, Animal; Eating; Glucagon; Gluconeogenesis; Humans; Insulin; Insulin-Like Growth Factor I; Leptin; Mice; Mice, Knockout; Oxygen Consumption; Peptides; Pyruvic Acid; Receptor, Insulin; Transcriptome; Uncoupling Protein 1 | 2020 |
Novel glucagon- and OXM-based peptides acting through glucagon and GLP-1 receptors with body weight reduction and anti-diabetic properties.
Topics: Amino Acid Sequence; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Energy Intake; Glucagon; Glucagon-Like Peptide-1 Receptor; Glucose Tolerance Test; Hypoglycemic Agents; Mice; Obesity; Oxyntomodulin; Peptides; Sequence Homology, Amino Acid; Streptozocin; Structure-Activity Relationship; Weight Loss | 2020 |
Berberine Attenuates Hyperglycemia by Inhibiting the Hepatic Glucagon Pathway in Diabetic Mice.
Topics: Animals; Berberine; Diabetes Mellitus, Experimental; Glucagon; Hyperglycemia; Liver; Mice; Mice, Obese; Signal Transduction | 2020 |
Liraglutide and sitagliptin counter beta- to alpha-cell transdifferentiation in diabetes.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Blood Glucose; Cell Proliferation; Cell Transdifferentiation; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Secreting Cells; Hydrocortisone; Hypoglycemic Agents; Insulin; Insulin-Secreting Cells; Liraglutide; Mice, Inbred C57BL; Mice, Transgenic; Sitagliptin Phosphate | 2020 |
Glucagon from the phylogenetically ancient paddlefish provides a template for the design of a long-acting peptide with effective anti-diabetic and anti-obesity activities.
Topics: Amino Acid Sequence; Animals; Anti-Obesity Agents; Apoptosis; Blood Glucose; Body Weight; Cell Proliferation; Cytokines; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose Transporter Type 2; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Insulin-Secreting Cells; Islets of Langerhans; Male; Mice; Neoplasm Proteins; Obesity; Receptors, Glucagon; Structure-Activity Relationship | 2020 |
Dapagliflozin exerts positive effects on beta cells, decreases glucagon and does not alter beta- to alpha-cell transdifferentiation in mouse models of diabetes and insulin resistance.
Topics: Animals; Benzhydryl Compounds; Blood Glucose; Body Weight; Cell Transdifferentiation; Diabetes Mellitus, Experimental; Diet, High-Fat; Energy Intake; Glucagon; Glucagon-Secreting Cells; Glucosides; Homeodomain Proteins; Hydrocortisone; Insulin; Insulin Resistance; Insulin-Secreting Cells; Islets of Langerhans; Male; Mice, Transgenic; Sodium-Glucose Transporter 2 Inhibitors; Streptozocin; Trans-Activators | 2020 |
A co-formulation of supramolecularly stabilized insulin and pramlintide enhances mealtime glucagon suppression in diabetic pigs.
Topics: Animals; Bridged-Ring Compounds; Diabetes Mellitus, Experimental; Diffusion; Drug Administration Routes; Drug Compounding; Drug Stability; Glucagon; Hydrogen-Ion Concentration; Imidazoles; Insulin; Islet Amyloid Polypeptide; Male; Polyethylene Glycols; Rats, Sprague-Dawley; Signal Transduction; Swine | 2020 |
Functional β-Cell Differentiation of Small-Tail Han Sheep Pancreatic Mesenchymal Stem Cells and the Therapeutic Potential in Type 1 Diabetic Mice.
Topics: Animals; Blood Glucose; Body Weight; C-Peptide; Cell Differentiation; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Glucagon; Glucose; Humans; Insulin; Insulin Secretion; Insulin-Secreting Cells; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice; Sheep | 2020 |
Modulatory role of imatinib mesylate on pancreatic β-cells' secretory functions in an STZ rat model of diabetes mellitus.
Topics: Administration, Oral; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Antioxidants; Biomarkers; Blood Glucose; Body Weight; Caspase 3; Catalase; Diabetes Mellitus, Experimental; Disease Models, Animal; Glucagon; Glutathione; Imatinib Mesylate; Insulin; Insulin-Secreting Cells; Male; Malondialdehyde; Organ Size; Oxidation-Reduction; Oxidative Stress; Rats, Sprague-Dawley; Streptozocin; Superoxide Dismutase | 2020 |
Dapagliflozin promotes beta cell regeneration by inducing pancreatic endocrine cell phenotype conversion in type 2 diabetic mice.
Topics: Animals; Benzhydryl Compounds; Blood Glucose; C-Peptide; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, Animal; Endocrine Cells; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Secreting Cells; Glucose; Glucosides; Insulin; Insulin-Secreting Cells; Male; Mice; Proprotein Convertase 1; Regeneration; Sodium-Glucose Transporter 2 Inhibitors | 2020 |
Identification of an Anti-diabetic, Orally Available Small Molecule that Regulates TXNIP Expression and Glucagon Action.
Topics: Administration, Oral; Animals; Carrier Proteins; Cells, Cultured; Diabetes Mellitus, Experimental; Glucagon; Humans; Hypoglycemic Agents; Male; Mice; Mice, Inbred C57BL; Rats; Small Molecule Libraries; Streptozocin | 2020 |
An Inducible Diabetes Mellitus Murine Model Based on MafB Conditional Knockout under MafA-Deficient Condition.
Topics: Animals; Diabetes Mellitus; Diabetes Mellitus, Experimental; Disease Models, Animal; Gene Expression Regulation; Glucagon; Glucose Tolerance Test; Insulin; Insulin-Secreting Cells; Islets of Langerhans; Maf Transcription Factors, Large; MafB Transcription Factor; Mice, Knockout | 2020 |
Rational design of a GLP-1/GIP/Gcg receptor triagonist to correct hyperglycemia, obesity and diabetic nephropathy in rodent animals.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Drug Design; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide-1 Receptor; Hyperglycemia; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Obesity | 2020 |
Ghrelin Protects Against Insulin-Induced Hypoglycemia in a Mouse Model of Type 1 Diabetes Mellitus.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Epinephrine; Ghrelin; Glucagon; Hypoglycemia; Insulin; Mice; Mice, Knockout; Norepinephrine | 2020 |
Transdifferentiation of both intra- and extra-islet cells into beta cells in nicotinamide treated neonatal diabetic rats: An in situ hybridization and double immunohistochemical study.
Topics: Animals; Blood Glucose; Cell Transdifferentiation; Diabetes Mellitus, Experimental; Glucagon; In Situ Hybridization; Insulin; Insulin-Secreting Cells; Islets of Langerhans; Niacinamide; Pancreas; Rats, Wistar; Streptozocin | 2020 |
Si-Miao-Yong-An decoction preserves cardiac function and regulates GLC/AMPK/NF-κB and GLC/PPARα/PGC-1α pathways in diabetic mice.
Topics: AMP-Activated Protein Kinases; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Drugs, Chinese Herbal; Glucagon; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; PPAR alpha; Signal Transduction; Streptozocin | 2020 |
Dual self-regulated delivery of insulin and glucagon by a hybrid patch.
Topics: Animals; Blood Glucose; Delayed-Action Preparations; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Drug Combinations; Drug Compounding; Drug Delivery Systems; Drug Liberation; Drug Overdose; Glucagon; Humans; Hypoglycemic Agents; Insulin; Male; Mice; Polymerization; Solubility; Streptozocin; Transdermal Patch | 2020 |
Amylase-Dependent Regulation of Glucose Metabolism and Insulin/Glucagon Secretion in the Streptozotocin-Induced Diabetic Pig Model and in a Rat Pancreatic Beta-Cell Line, BRIN-BD11.
Topics: Amylases; Animals; Blood Glucose; Cell Line; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Glucagon; Glucose Tolerance Test; Infusions, Intravenous; Insulin; Insulin-Secreting Cells; Rats; Secretory Pathway; Streptozocin; Sus scrofa; Time Factors | 2020 |
Development and characterisation of novel, enzymatically stable oxytocin analogues with beneficial antidiabetic effects in high fat fed mice.
Topics: Animals; Blood Glucose; Cholesterol, HDL; Cholesterol, LDL; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Energy Intake; Female; Glucagon; Half-Life; Hypoglycemic Agents; Insulin; Insulin Resistance; Insulin Secretion; Islets of Langerhans; Male; Mice; Obesity; Oligopeptides; Oxytocin; Protein Stability; Triglycerides | 2021 |
S3-2, a novel long-lasting oxyntomodulin derivative, exerts improvement on diabesity and renal injury through activating GLP-1 and glucagon receptors.
Topics: Albumins; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Disease Models, Animal; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose; Hypoglycemic Agents; Insulin; Kidney; Male; Mice; Mice, Inbred C57BL; Obesity; Oxyntomodulin; Peptides; Receptors, Glucagon | 2021 |
Role of zonulin and GLP-1/DPP-IV in alleviation of diabetes mellitus by peptide/polypeptide fraction of Aloe vera in streptozotocin- induced diabetic wistar rats.
Topics: Aloe; Animals; Blood Glucose; Cell Survival; Cytokines; Diabetes Mellitus, Experimental; Dipeptidyl Peptidase 4; Glucagon; Glucagon-Like Peptide 1; Glucose-6-Phosphate; Glycogen; Haptoglobins; Hexokinase; Hypoglycemic Agents; Inflammation; Insulin; Intestine, Small; Liver; Nitric Oxide; Pancreas; Plant Extracts; Protein Precursors; Rats, Wistar; Streptozocin | 2021 |
Glucagon blockade restores functional β-cell mass in type 1 diabetic mice and enhances function of human islets.
Topics: Animals; Antibodies, Monoclonal; Blood Glucose; C-Peptide; Cell Lineage; Cell Transdifferentiation; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Gene Expression; Glucagon; Glucagon-Secreting Cells; Humans; Hypoglycemic Agents; Insulin; Insulin-Secreting Cells; Islets of Langerhans; Islets of Langerhans Transplantation; Mice; Mice, Inbred NOD; Organ Size; Receptors, Glucagon; Treatment Outcome | 2021 |
Transdermal delivery of a somatostatin receptor type 2 antagonist using microneedle patch technology for hypoglycemia prevention.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Drug Delivery Systems; Glucagon; Humans; Hypoglycemia; Insulin; Needles; Polymers; Rats; Receptors, Somatostatin; Technology; Transdermal Patch | 2022 |
Beneficial effects of physical exercise for β-cell maintenance in a type 1 diabetes mellitus animal model.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Glucagon; Insulin; Insulin-Secreting Cells; Islets of Langerhans; Mice | 2021 |
Disordered branched chain amino acid catabolism in pancreatic islets is associated with postprandial hypersecretion of glucagon in diabetic mice.
Topics: Amino Acids, Branched-Chain; Animals; Calcium; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucagon; Islets of Langerhans; Male; Mice; Mice, Inbred C57BL; Palmitates; Postprandial Period | 2021 |
Synthesis and anti-diabetic activity of novel biphenylsulfonamides as glucagon receptor antagonists.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucagon; Glucose; Glucose Tolerance Test; Humans; Hyperglycemia; Hypoglycemic Agents; Male; Mice, Inbred C57BL; Molecular Structure; Receptors, Glucagon; Structure-Activity Relationship; Sulfonamides | 2021 |
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Gastrointestinal Microbiome; Glucagon; Hyperglycemia; Lacticaseibacillus rhamnosus; Mice; Signal Transduction | 2021 |
Hormonal regulation of glycine decarboxylase and its relationship to oxidative stress.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Gastrointestinal Agents; Gene Expression Regulation, Enzymologic; Glucagon; Glutathione; Glycine; Glycine Dehydrogenase (Decarboxylating); HEK293 Cells; Humans; Male; Mice; Mice, Inbred C57BL; Oxidative Stress; Rats; Rats, Sprague-Dawley | 2021 |
Protein kinase C-δ signaling regulates glucagon secretion from pancreatic islets.
Topics: Animals; Diabetes Mellitus, Experimental; Disease Progression; Glucagon; Humans; In Vitro Techniques; Islets of Langerhans; Male; Mice; Mice, Inbred C57BL; Phosphorylation; Protein Kinase C-delta; Quercetin; Signal Transduction; Tetradecanoylphorbol Acetate | 2017 |
Dapagliflozin suppresses glucagon signaling in rodent models of diabetes.
Topics: Animals; Benzhydryl Compounds; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Down-Regulation; Glucagon; Glucagon-Secreting Cells; Glucose; Glucosides; Hypoglycemic Agents; Kidney Tubules, Proximal; Male; Mice; Rats; Rats, Sprague-Dawley; Rats, Zucker; Rodentia; Signal Transduction; Sodium-Glucose Transporter 2 | 2017 |
Metabolic and neuroprotective effects of dapagliflozin and liraglutide in diabetic mice.
Topics: Animals; Benzhydryl Compounds; Blood Glucose; Diabetes Mellitus, Experimental; Glucagon; Glucagon-Like Peptide 1; Glucagon-Secreting Cells; Glucosides; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Interleukin-6; Liraglutide; Male; Mice; Neurons; Neuroprotective Agents | 2017 |
A novel glucagon-like peptide-1/glucagon receptor dual agonist exhibits weight-lowering and diabetes-protective effects.
Topics: Animals; Body Weight; Diabetes Mellitus, Experimental; Glucagon; Glucagon-Like Peptide 1; HEK293 Cells; Humans; Hyperglycemia; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Obese; Receptors, Glucagon | 2017 |
Transplantation of stromal-derived factor 1α and basic fibroblast growth factor primed insulin-producing cells reverses hyperglycaemia in diabetic rats.
Topics: Animals; Blood Glucose; Cells, Cultured; Chemokine CXCL12; Diabetes Mellitus, Experimental; Female; Fibroblast Growth Factors; Glucagon; Hyperglycemia; Insulin; Insulin-Secreting Cells; Islets of Langerhans Transplantation; Male; Rats; Rats, Sprague-Dawley | 2017 |
Ectopic expression of
Topics: Animals; Cell Proliferation; Cell Transdifferentiation; Diabetes Mellitus, Experimental; Ectopic Gene Expression; Genetic Therapy; Glucagon; Homeodomain Proteins; Insulin; Insulin-Secreting Cells; Male; Mice; Mice, Transgenic; Paired Box Transcription Factors; Somatostatin; Somatostatin-Secreting Cells; Streptozocin | 2017 |
Lipid nanoparticle delivery of glucagon receptor siRNA improves glucose homeostasis in mouse models of diabetes.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diet, High-Fat; Glucagon; Homeostasis; Hyperglycemia; Insulin; Leptin; Male; Mice; Mice, Inbred C57BL; Nanoparticles; Receptors, Glucagon; RNA, Small Interfering | 2017 |
Honokiol protects pancreatic β cell against high glucose and intermittent hypoxia-induced injury by activating Nrf2/ARE pathway in vitro and in vivo.
Topics: Animals; Apoptosis; Biphenyl Compounds; Blood Glucose; Cell Proliferation; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Free Radical Scavengers; Glucagon; Hypoxia; Insulin; Insulin Resistance; Insulin-Secreting Cells; Lignans; NF-E2-Related Factor 2; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Sleep Apnea, Obstructive | 2018 |
Endogenous Reprogramming of Alpha Cells into Beta Cells, Induced by Viral Gene Therapy, Reverses Autoimmune Diabetes.
Topics: Alloxan; Animals; Blood Glucose; Cellular Reprogramming; Dependovirus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Gene Expression Profiling; Genetic Therapy; Glucagon; Glucagon-Secreting Cells; Homeodomain Proteins; Humans; Hyperglycemia; Insulin; Insulin-Secreting Cells; Lectins, C-Type; Mice, Inbred C57BL; Mice, SCID; Receptors, Immunologic; Trans-Activators | 2018 |
In Uncontrolled Diabetes, Hyperglucagonemia and Ketosis Result From Deficient Leptin Action in the Parabrachial Nucleus.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucagon; Injections, Intraventricular; Insulin; Ketosis; Leptin; Male; Mice; Neurons; Parabrachial Nucleus; Rats; Rats, Wistar; Signal Transduction | 2018 |
Pancreatic alpha cells in diabetic rats express active GLP-1 receptor: Endosomal co-localization of GLP-1/GLP-1R complex functioning through intra-islet paracrine mechanism.
Topics: Animals; Diabetes Mellitus, Experimental; Endosomes; Fluorescent Antibody Technique, Direct; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Secreting Cells; Islets of Langerhans; Male; Protein Binding; Protein Transport; Rats | 2018 |
Vildagliptin/pioglitazone combination improved the overall glycemic control in type I diabetic rats.
Topics: Adamantane; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Drug Therapy, Combination; Glucagon; Glutathione; Glycated Hemoglobin; Insulin; Male; Malondialdehyde; Nitric Oxide; Nitriles; Pancreas; Pioglitazone; Pyrrolidines; Rats, Sprague-Dawley; Streptozocin; Superoxide Dismutase; Thiazolidinediones; Vildagliptin | 2018 |
Paracrine Interactions within the Pancreatic Islet Determine the Glycemic Set Point.
Topics: Animals; Diabetes Mellitus, Experimental; Glucagon; Glucagon-Secreting Cells; Glucose; Humans; Hypoglycemic Agents; Insulin-Secreting Cells; Islets of Langerhans Transplantation; Macaca fascicularis; Mice; Mice, Inbred C57BL; Mice, Nude; Paracrine Communication; Receptors, Glucagon | 2018 |
Sustained effect of glucagon on body weight and blood glucose: Assessed by continuous glucose monitoring in diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Drug Therapy, Combination; Energy Metabolism; Fibroblast Growth Factors; Glucagon; Hypoglycemic Agents; Insulin; Rats; Rats, Sprague-Dawley | 2018 |
Dual treatment with a fixed ratio of glucagon and insulin increases the therapeutic window of insulin in diabetic rats.
Topics: Animals; Blood Glucose; Cells, Cultured; Diabetes Mellitus, Experimental; Glucagon; Hepatocytes; Insulin; Male; Rats; Rats, Sprague-Dawley | 2018 |
GPR119 Agonism Increases Glucagon Secretion During Insulin-Induced Hypoglycemia.
Topics: Adult; Animals; Cells, Cultured; Diabetes Mellitus, Experimental; Glucagon; Glucose Tolerance Test; Humans; Hypoglycemia; Hypoglycemic Agents; Insulin; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Streptozocin; Young Adult | 2018 |
Secretagogin is increased in plasma from type 2 diabetes patients and potentially reflects stress and islet dysfunction.
Topics: Adult; Aged; Animals; Biomarkers; Cell Nucleus; Cohort Studies; Cytokines; Cytoplasm; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Endoplasmic Reticulum; Enzyme-Linked Immunosorbent Assay; Female; Glucagon; Glucose; Glucose Tolerance Test; Humans; Insulin-Secreting Cells; Islets of Langerhans; Islets of Langerhans Transplantation; Male; Mice; Middle Aged; Secretagogins | 2018 |
Additive effects of evogliptin in combination with pioglitazone on fasting glucose control through direct and indirect hepatic effects in diabetic mice.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dipeptidyl-Peptidase IV Inhibitors; Drug Synergism; Fasting; Glucagon; Glucose; Hep G2 Cells; Humans; Liver; Male; Mice; Pioglitazone; Piperazines; Thiazolidinediones | 2018 |
Effectiveness of bioengineered islet cell sheets for the treatment of diabetes mellitus.
Topics: Abdominal Cavity; Animals; Basic Helix-Loop-Helix Transcription Factors; Blood Glucose; Cell Survival; Cells, Cultured; Diabetes Mellitus, Experimental; DNA Methylation; Glucagon; Homeodomain Proteins; Humans; Hyperglycemia; Insulin; Islets of Langerhans; Islets of Langerhans Transplantation; Mice; Mice, SCID; Nerve Tissue Proteins; Primary Cell Culture; Promoter Regions, Genetic; Streptozocin; Tissue Engineering; Trans-Activators; Treatment Outcome | 2018 |
Dendrobium Officinale Kimura et Migo Ameliorates Insulin Resistance in Rats with Diabetic Nephropathy.
Topics: Animals; C-Reactive Protein; Cytokines; Dendrobium; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Female; Glucagon; Insulin; Insulin Resistance; Interleukin-6; Rats; Rats, Sprague-Dawley; Toll-Like Receptors; Tumor Necrosis Factor-alpha | 2018 |
Effect of nociceptin on insulin release in normal and diabetic rat pancreas.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Glucagon; Insulin; Insulin Secretion; Male; Models, Biological; Nociceptin; Opioid Peptides; Pancreas; Pancreatic Polypeptide; Rats, Wistar; Somatostatin | 2018 |
Deletion of the glucagon receptor gene before and after experimental diabetes reveals differential protection from hyperglycemia.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Disease Models, Animal; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide-1 Receptor; Hyperglycemia; Insulin; Insulin-Secreting Cells; Male; Mice; Mice, Knockout; Receptors, Glucagon; Streptozocin; Transcriptome | 2018 |
Insulin regulates GLUT4 in the ventromedial hypothalamus to restore the sympathoadrenal response to hypoglycemia in diabetic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Epinephrine; Glucagon; Glucose Clamp Technique; Glucose Transporter Type 4; Hypoglycemia; Hypoglycemic Agents; Insulin; Male; Rats; Rats, Sprague-Dawley; Ventromedial Hypothalamic Nucleus | 2018 |
SIRT1 activation attenuates α cell hyperplasia, hyperglucagonaemia and hyperglycaemia in STZ-diabetic mice.
Topics: Anilides; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucagon; Hyperglycemia; Hyperplasia; Insulin; Male; Mice; Sirtuin 1; Thiazoles | 2018 |
Dynamic changes in insulin and glucagon during disease progression in rhesus monkeys with obesity-related type 2 diabetes mellitus.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Progression; Glucagon; Glucose Tolerance Test; Insulin; Macaca mulatta; Male; Monitoring, Physiologic; Obesity | 2019 |
Resistance Exercise Training Attenuates the Loss of Endogenous GLP-1 Receptor in the Hypothalamus of Type 2 Diabetic Rats.
Topics: Animals; Antioxidants; Blood Glucose; Body Weight; Cyclic AMP-Dependent Protein Kinases; Diabetes Mellitus, Experimental; Energy Intake; Glucagon; Glucagon-Like Peptide-1 Receptor; Glucose Transporter Type 2; Hypothalamus; Male; Proto-Oncogene Proteins c-akt; Rats; Resistance Training | 2019 |
Glucagon receptor antagonism increases mouse pancreatic δ-cell mass through cell proliferation and duct-derived neogenesis.
Topics: Animals; Animals, Newborn; Antibodies, Monoclonal; Cell Proliferation; Cell Shape; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Glucagon; Humans; Hypoglycemic Agents; Insulin; Mice, Inbred C57BL; Receptors, Glucagon; Somatostatin; Somatostatin-Secreting Cells | 2019 |
Temporal analysis of distribution pattern of islet cells and antioxidant enzymes for diabetes onset in postnatal critical development window in rats.
Topics: Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Female; Glucagon; Glucose; Hyperglycemia; Insulin; Insulin-Secreting Cells; Islets of Langerhans; Male; Pancreas; Pregnancy; Rats; Rats, Wistar; Spatio-Temporal Analysis; Streptozocin | 2019 |
Modulatory effect of empagliflozin on cellular parameters of endocrine pancreas in experimental pre-diabetes.
Topics: Animals; Area Under Curve; Benzhydryl Compounds; Blood Glucose; Caspase 3; Cell Proliferation; Cytokines; Diabetes Mellitus, Experimental; Glucagon; Glucagon-Secreting Cells; Glucose Tolerance Test; Glucosides; Homeostasis; Immunohistochemistry; Insulin-Secreting Cells; Islets of Langerhans; Male; Prediabetic State; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Sodium-Glucose Transporter 2 Inhibitors | 2019 |
Induction of α cell-restricted Gc in dedifferentiating β cells contributes to stress-induced β-cell dysfunction.
Topics: Animals; Cell Dedifferentiation; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Epigenomics; Female; Forkhead Box Protein O1; Gene Expression Regulation; Glucagon; Glucagon-Secreting Cells; Histones; Insulin; Insulin-Secreting Cells; Male; Mice; Mice, Knockout; Parity; Transcriptome; Vitamin D-Binding Protein | 2019 |
Glucose-Responsive Composite Microneedle Patch for Hypoglycemia-Triggered Delivery of Native Glucagon.
Topics: Animals; Blood Glucose; Cross-Linking Reagents; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Drug Liberation; Gels; Glucagon; Humans; Hyaluronic Acid; Hypoglycemia; Hypoglycemic Agents; Insulin; Methacrylates; Needles; Photochemical Processes; Polymerization; Rats; Transdermal Patch | 2019 |
Antidiabetic Activity and Potential Mechanism of Amentoflavone in Diabetic Mice.
Topics: Animals; Biflavonoids; Biomarkers; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Fasting; Fatty Liver; Glucagon; Glucose; Glucose Tolerance Test; Hypoglycemic Agents; Insulin; Lipid Metabolism; Lipids; Lipoproteins; Liver; Mice; Muscle, Skeletal; Oxidation-Reduction; Phosphorylation | 2019 |
Pancreatic alpha-cell mass in the early-onset and advanced stage of a mouse model of experimental autoimmune diabetes.
Topics: Animals; B7-1 Antigen; Cell Proliferation; Cell Transdifferentiation; Diabetes Mellitus, Experimental; Disease Models, Animal; Glucagon; Glucagon-Secreting Cells; Homeodomain Proteins; Hyperglycemia; Insulin; Mice; Mice, Inbred C57BL; Mice, Transgenic; Trans-Activators | 2019 |
Nilotinib enhances β-islets integrity and secretory functions in a rat model of STZ-induced diabetes mellitus.
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Apoptosis; Blood Glucose; Body Weight; Caspase 3; Catalase; Diabetes Mellitus, Experimental; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression Regulation, Enzymologic; Glucagon; Glutathione; Insulin; Insulin-Secreting Cells; Male; Malondialdehyde; Organ Size; Oxidative Stress; Pyrimidines; Rats; Rats, Sprague-Dawley; Superoxide Dismutase | 2019 |
Amelioration of hypoglycemia via somatostatin receptor type 2 antagonism in recurrently hypoglycemic diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Catecholamines; Diabetes Mellitus, Experimental; Eating; Glucagon; Hypoglycemia; Insulin; Peptides, Cyclic; Rats; Receptors, Somatostatin | 2013 |
cAMP-responsive element-binding protein (CREB)-regulated transcription coactivator 2 (CRTC2) promotes glucagon clearance and hepatic amino acid catabolism to regulate glucose homeostasis.
Topics: Amino Acids; Animals; Antibodies, Neutralizing; Diabetes Mellitus, Experimental; Gene Knockdown Techniques; Glucagon; Gluconeogenesis; Glucose; Homeostasis; Liver; Mice; Pyridoxal Phosphate; Rats; Trans-Activators; Transcription Factors | 2013 |
The protective effects of beta-casomorphin-7 against glucose -induced renal oxidative stress in vivo and vitro.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Glucose; Cell Line; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Endorphins; Epithelial Cells; Glucagon; Glutathione Peroxidase; Hydrogen Peroxide; Insulin; Isoenzymes; Kidney; Losartan; Male; Malondialdehyde; Oxidative Stress; Peptide Fragments; Peptidyl-Dipeptidase A; Rats; Rats, Sprague-Dawley; Superoxide Dismutase | 2013 |
Effect of combined therapy of human Wharton's jelly-derived mesenchymal stem cells from umbilical cord with sitagliptin in type 2 diabetic rats.
Topics: Animals; C-Peptide; Cell Proliferation; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, Animal; Glucagon; Glycated Hemoglobin; Hypoglycemic Agents; Insulin; Insulin-Secreting Cells; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Pyrazines; Rats; Rats, Wistar; Sitagliptin Phosphate; Streptozocin; Treatment Outcome; Triazoles; Umbilical Cord | 2014 |
Increasing glucagon secretion could antagonize the action of exogenous insulin for glycemic control in streptozocin-induced diabetic rhesus monkeys.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Disease Models, Animal; Dose-Response Relationship, Drug; Glucagon; Glucagon-Secreting Cells; Hypoglycemic Agents; Insulin; Insulin Resistance; Longitudinal Studies; Macaca mulatta; Streptozocin; Time Factors; Treatment Outcome; Triglycerides | 2013 |
Multiple intravenous infusions of bone marrow mesenchymal stem cells reverse hyperglycemia in experimental type 2 diabetes rats.
Topics: Administration, Intravenous; Animals; Blood Glucose; Bone Marrow; C-Peptide; Culture Media, Conditioned; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Glucagon; Glucose Tolerance Test; Hyperglycemia; Hypoglycemic Agents; Insulin; Islets of Langerhans; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Rats; Rats, Sprague-Dawley; Streptozocin | 2013 |
Beneficial effects of parenteral GLP-1 delivery by cell therapy in insulin-deficient streptozotocin diabetic mice.
Topics: Animals; Blood Glucose; Body Weight; Cell Line; Cell Transplantation; Diabetes Mellitus, Experimental; Eating; Female; Glucagon; Glucagon-Like Peptide 1; Glucose Intolerance; Insulin; Insulin-Secreting Cells; Male; Mice; Mice, SCID; Streptozocin | 2013 |
Biochemical and immunohistochemical changes in delta-9-tetrahydrocannabinol-treated type 2 diabetic rats.
Topics: Animals; Blood Glucose; Cannabinoid Receptor Agonists; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dronabinol; Drug Evaluation, Preclinical; Glucagon; Insulin; Islets of Langerhans; Lipid Metabolism; Lipoproteins; Male; Rats, Sprague-Dawley | 2014 |
Metabolic disturbances and defects in insulin secretion in rats with streptozotocin-nicotinamide-induced diabetes.
Topics: Animals; Cells, Cultured; Diabetes Mellitus, Experimental; Disease Models, Animal; Glucagon; Glucose; Insulin; Insulin Secretion; Insulin-Secreting Cells; Male; Niacinamide; Rats; Rats, Wistar; Severity of Illness Index; Streptozocin | 2013 |
Resveratrol prevents β-cell dedifferentiation in nonhuman primates given a high-fat/high-sugar diet.
Topics: Animals; Blood Glucose; Body Weight; Cell Dedifferentiation; Densitometry; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Dietary Sucrose; Disease Models, Animal; Fluorescent Antibody Technique; Glucagon; Glucagon-Like Peptide 1; Glucagon-Secreting Cells; Glucose Tolerance Test; Glycated Hemoglobin; Homeobox Protein Nkx-2.2; Homeodomain Proteins; Insulin; Insulin Resistance; Insulin-Secreting Cells; Islets of Langerhans; Macaca mulatta; Nuclear Proteins; Protective Agents; Resveratrol; Sirtuin 1; Stilbenes; Transcription Factors | 2013 |
Pancreatic duct ligation after almost complete β-cell loss: exocrine regeneration but no evidence of β-cell regeneration.
Topics: Animals; Diabetes Mellitus, Experimental; Glucagon; Insulin; Insulin-Secreting Cells; Ki-67 Antigen; Ligation; Male; Pancreatic Ducts; Pancreatic Polypeptide; Rats; Rats, Inbred Lew; Regeneration | 2013 |
The discovery of N-((2H-tetrazol-5-yl)methyl)-4-((R)-1-((5r,8R)-8-(tert-butyl)-3-(3,5-dichlorophenyl)-2-oxo-1,4-diazaspiro[4.5]dec-3-en-1-yl)-4,4-dimethylpentyl)benzamide (SCH 900822): a potent and selective glucagon receptor antagonist.
Topics: Animals; Benzamides; Blood Glucose; Cyclohexanones; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Drug Discovery; Glucagon; Mice; Mice, Inbred ICR; Obesity; Prediabetic State; Receptors, Glucagon; Spiro Compounds; Structure-Activity Relationship | 2014 |
Glycoprotein 130 receptor signaling mediates α-cell dysfunction in a rodent model of type 2 diabetes.
Topics: Animals; Cytokine Receptor gp130; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Glucagon; Glucagon-Secreting Cells; Interleukin-6; Male; Mice; Mice, Knockout; Phosphorylation; Rats; STAT3 Transcription Factor | 2014 |
Blockade of Na+ channels in pancreatic α-cells has antidiabetic effects.
Topics: Acetanilides; Animals; Diabetes Mellitus, Experimental; Exocytosis; Glucagon; Glucagon-Secreting Cells; Humans; Hypoglycemic Agents; Islets of Langerhans; Male; NAV1.3 Voltage-Gated Sodium Channel; Piperazines; Ranolazine; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers | 2014 |
Hypothalamic agouti-related peptide neurons and the central melanocortin system are crucial mediators of leptin's antidiabetic actions.
Topics: Agouti-Related Protein; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Female; Glucagon; Humans; Hypothalamus; Leptin; Male; Melanocortins; Mice; Mice, Transgenic; Neurons; Receptors, Leptin | 2014 |
Leptin reverses diabetes by suppression of the hypothalamic-pituitary-adrenal axis.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Glucagon; Gluconeogenesis; Hypothalamo-Hypophyseal System; Insulin; Leptin; Lipolysis; Pituitary-Adrenal System; Rats | 2014 |
GABA promotes human β-cell proliferation and modulates glucose homeostasis.
Topics: Animals; Apoptosis; Blood Glucose; Cell Proliferation; Diabetes Mellitus, Experimental; GABA Agents; gamma-Aminobutyric Acid; Glucagon; Homeostasis; Humans; Insulin; Insulin Secretion; Insulin-Secreting Cells; Islets of Langerhans Transplantation; Mice; Mice, Inbred NOD; Mice, SCID | 2014 |
Two novel glucagon receptor antagonists prove effective therapeutic agents in high-fat-fed and obese diabetic mice.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diet, High-Fat; Drug Administration Schedule; Eating; Glucagon; Hypoglycemic Agents; Mice; Mice, Obese; Receptors, Glucagon | 2014 |
Novel antidiabetic nutrients identified by in vivo screening for gastric secretion and emptying regulation in rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Disease Models, Animal; Food; Gastric Emptying; Glucagon; Hyperglycemia; Hypoglycemic Agents; Insulin; Male; Postprandial Period; Rats, Wistar | 2014 |
Islet remodeling in female mice with spontaneous autoimmune and streptozotocin-induced diabetes.
Topics: Animals; Blood Glucose; Cell Proliferation; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Secreting Cells; Immunohistochemistry; Insulin; Insulin-Secreting Cells; Islets of Langerhans; Mice, Inbred BALB C; Mice, Inbred NOD; Somatostatin | 2014 |
The effect of glucagon-like peptide-1 in the management of diabetes mellitus: cellular and molecular mechanisms.
Topics: Animals; Blood Glucose; Body Weight; Catalase; Diabetes Mellitus, Experimental; Exenatide; Fluorescent Antibody Technique; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Glutathione Reductase; Insulin; Insulin Secretion; Islets of Langerhans; Kidney; Lipids; Liver; Male; Peptides; Rats, Wistar; Time Factors; Venoms | 2014 |
A novel, stable, aqueous glucagon formulation using ferulic acid as an excipient.
Topics: Animals; Blood Glucose; Coumaric Acids; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Drug Delivery Systems; Drug Stability; Excipients; Glucagon; Humans; Infusion Pumps; Pharmaceutical Solutions; Swine; Water | 2015 |
Development of stable liquid glucagon formulations for use in artificial pancreas.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Dogs; Drug Delivery Systems; Drug Stability; Female; Glucagon; Humans; Male; Pancreas, Artificial; Pharmaceutical Solutions; Swine | 2015 |
Possible contribution of taurine to distorted glucagon secretion in intra-islet insulin deficiency: a metabolome analysis using a novel α-cell model of insulin-deficient diabetes.
Topics: Animals; Cell Line; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Gene Knockdown Techniques; Glucagon; Glucagon-Secreting Cells; Male; Mice; Mice, Inbred ICR; Receptor, Insulin; Taurine | 2014 |
The constitutive activation of Egr-1/C/EBPa mediates the development of type 2 diabetes mellitus by enhancing hepatic gluconeogenesis.
Topics: Animals; CCAAT-Enhancer-Binding Proteins; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Early Growth Response Protein 1; Glucagon; Gluconeogenesis; Glucose; Liver; Male; Mice | 2015 |
Morphological assessment of pancreatic islet hormone content following aerobic exercise training in rats with poorly controlled Type 1 diabetes mellitus.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Glucagon; Glucose Transporter Type 4; Insulin; Islets of Langerhans; Male; Physical Conditioning, Animal; Rats; Rats, Sprague-Dawley; Receptor, Insulin | 2014 |
Evidence That in Uncontrolled Diabetes, Hyperglucagonemia Is Required for Ketosis but Not for Increased Hepatic Glucose Production or Hyperglycemia.
Topics: Animals; Diabetes Mellitus, Experimental; Forkhead Box Protein O1; Forkhead Transcription Factors; Glucagon; Glucagon-Like Peptide 1; Glucose; Hyperglycemia; Insulin; Ketone Bodies; Ketosis; Liraglutide; Liver; Male; Rats, Wistar; Receptors, Glucagon; Streptozocin | 2015 |
Glucagon receptor antibody completely suppresses type 1 diabetes phenotype without insulin by disrupting a novel diabetogenic pathway.
Topics: Animals; Antibodies, Monoclonal; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Female; Glucagon; Humans; Insulin; Mice; Mice, Inbred NOD; Paracrine Communication; Rats; Rats, Zucker; Receptors, Glucagon | 2015 |
Effects of autologous adipose-derived stem cell infusion on type 2 diabetic rats.
Topics: Adipocytes; Adipose Tissue; Adult Stem Cells; Animals; Autografts; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucagon; Insulin; Male; Rats; Rats, Sprague-Dawley; Stem Cell Transplantation | 2015 |
The effects of exendin-4 treatment on graft failure: an animal study using a novel re-vascularized minimal human islet transplant model.
Topics: Animals; Apoptosis; Blood Glucose; C-Peptide; Cell Count; Diabetes Mellitus, Experimental; Exenatide; Fasting; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Graft Survival; Humans; Hyperglycemia; Insulin; Insulin Secretion; Insulin-Secreting Cells; Islets of Langerhans; Islets of Langerhans Transplantation; Male; Mice, Inbred BALB C; Models, Animal; Peptides; Venoms | 2015 |
Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells into Insulin-Producing Cells: Evidence for Further Maturation In Vivo.
Topics: Animals; Blood Glucose; Bone Marrow Cells; Cell Differentiation; Diabetes Mellitus, Experimental; Glucagon; Humans; Insulin; Insulin Secretion; Insulin-Secreting Cells; Islets of Langerhans; Islets of Langerhans Transplantation; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice; Mice, Inbred NOD | 2015 |
Sustained treatment with a stable long-acting oxyntomodulin analogue improves metabolic control and islet morphology in an experimental model of type 1 diabetes.
Topics: Animals; Apoptosis; Blood Glucose; Cell Proliferation; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Eating; Gastrointestinal Hormones; Glucagon; Hypoglycemic Agents; Insulin; Insulin Resistance; Insulin Secretion; Insulin-Secreting Cells; Islets of Langerhans; Mice; Oxyntomodulin; Pancreas | 2015 |
Fibroblast growth factor 21 prevents glycemic deterioration in insulin deficient mouse models of diabetes.
Topics: Adipose Tissue; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Female; Fibroblast Growth Factors; Glucagon; Insulin; Mice, Inbred C57BL; Obesity; Pancreas | 2015 |
A Novel TGR5 Activator WB403 Promotes GLP-1 Secretion and Preserves Pancreatic β-Cells in Type 2 Diabetic Mice.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Glucose Intolerance; Glucose Tolerance Test; Insulin-Secreting Cells; Mice; Postprandial Period; Receptors, G-Protein-Coupled | 2015 |
Diabetes Is Reversed in a Murine Model by Marginal Mass Syngeneic Islet Transplantation Using a Subcutaneous Cell Pouch Device.
Topics: Animals; Bioartificial Organs; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Equipment Design; Glucagon; Insulin; Islets of Langerhans; Islets of Langerhans Transplantation; Male; Mice, Inbred BALB C; Microvessels; Neovascularization, Physiologic; Pancreas, Artificial; Time Factors; Transplantation, Isogeneic | 2015 |
Rapid, high efficiency isolation of pancreatic ß-cells.
Topics: Animals; Boron Compounds; Cell Separation; Diabetes Mellitus, Experimental; Exenatide; Female; Gene Expression Profiling; Glucagon; Insulin; Insulin-Secreting Cells; Mice, Inbred C57BL; Mice, Inbred NOD; Peptides; Somatostatin; Venoms | 2015 |
Immunohistochemical, apoptotic and biochemical changes by dipeptidyl peptidase-4 inhibitor-sitagliptin in type-2 diabetic rats.
Topics: Animals; Animals, Newborn; Apoptosis; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Glucagon; Glucagon-Like Peptide 1; Islets of Langerhans; Rats; Rats, Wistar; Sitagliptin Phosphate; Somatostatin | 2015 |
Microvesicles but Not Exosomes from Pathfinder Cells Stimulate Functional Recovery of the Pancreas in a Mouse Streptozotocin-Induced Diabetes Model.
Topics: Animals; Biomarkers; Blood Glucose; C-Peptide; Cell- and Tissue-Based Therapy; Cell-Derived Microparticles; Diabetes Mellitus, Experimental; Exosomes; Female; Glucagon; Insulin; Mice, Inbred C57BL; Pancreas; Paracrine Communication; Rats; Recovery of Function; Regeneration; Signal Transduction; Streptozocin; Time Factors | 2016 |
Effects of Caffeine and Lycopene in Experimentally Induced Diabetes Mellitus.
Topics: Administration, Oral; Animals; Antioxidants; Blood Glucose; Caffeine; Carotenoids; Central Nervous System Stimulants; Diabetes Mellitus, Experimental; Glucagon; Glycosuria; Immunohistochemistry; Insulin; Lycopene; Pancreas; Rats, Sprague-Dawley | 2016 |
PAX4 Gene Transfer Induces α-to-β Cell Phenotypic Conversion and Confers Therapeutic Benefits for Diabetes Treatment.
Topics: Animals; Cell Differentiation; Cells, Cultured; Dependovirus; Diabetes Mellitus, Experimental; Genetic Therapy; Genetic Vectors; Glucagon; Homeodomain Proteins; Humans; Insulin; Insulin-Secreting Cells; Mice; Paired Box Transcription Factors | 2016 |
Acute disruption of glucagon secretion or action does not improve glucose tolerance in an insulin-deficient mouse model of diabetes.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diphtheria Toxin; Glucagon; Glucagon-Like Peptide 1; Glucagon-Secreting Cells; Glucose Intolerance; Glucose Tolerance Test; Insulin; Insulin-Secreting Cells; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, Glucagon; Streptozocin | 2016 |
Ellagic acid in Emblica officinalis exerts anti-diabetic activity through the action on β-cells of pancreas.
Topics: Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Ellagic Acid; Fruit; Glucagon; Glutathione; Hypoglycemic Agents; Insulin; Insulin-Secreting Cells; Liver; Phyllanthus emblica; Phytotherapy; Plant Extracts; Rats; Thiobarbituric Acid Reactive Substances | 2017 |
Pancreatic glucose-dependent insulinotropic polypeptide (GIP) (1-30) expression is upregulated in diabetes and PEGylated GIP(1-30) can suppress the progression of low-dose-STZ-induced hyperglycaemia in mice.
Topics: Animals; Body Weight; Cell Proliferation; Diabetes Mellitus, Experimental; Dipeptidyl-Peptidase IV Inhibitors; Gastric Inhibitory Polypeptide; Glucagon; Hyperglycemia; Hypoglycemic Agents; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Peptide Fragments; Streptozocin | 2016 |
α-Cell Dysfunctions and Molecular Alterations in Male Insulinopenic Diabetic Mice Are Not Completely Corrected by Insulin.
Topics: Animals; Cell Differentiation; Diabetes Mellitus, Experimental; Glucagon; Glucagon-Secreting Cells; Insulin; Male; Mice; Mice, Transgenic; Stress, Physiological | 2016 |
Insulin Knockout Mice Have Extended Survival but Volatile Blood Glucose Levels on Leptin Therapy.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Cholesterol; Corticosterone; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Fatty Acids; Glucagon; Glycerol; Hyperglycemia; Hypoglycemia; Insulin; Leptin; Mice; Mice, Knockout; Peptides; Receptor, Insulin; Triglycerides | 2016 |
Autophagy deficiency in β cells blunts incretin-induced suppression of glucagon release from α cells.
Topics: Animals; Autophagy; Diabetes Mellitus, Experimental; Glucagon; Glucagon-Secreting Cells; Glucose Intolerance; Incretins; Insulin-Secreting Cells; Islets of Langerhans; Male; Mice | 2015 |
Pancreatic α-Cells and Insulin-Deficient Diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Glucagon; Glucagon-Secreting Cells; Insulin; Male | 2016 |
HIF2α Is an Essential Molecular Brake for Postprandial Hepatic Glucagon Response Independent of Insulin Signaling.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Blood Glucose; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Diabetes Mellitus, Experimental; Glucagon; Gluconeogenesis; Hepatocytes; Hyperglycemia; Insulin; Liver; Mice, Inbred C57BL; Mice, Transgenic; Postprandial Period; Primary Cell Culture; Signal Transduction; Von Hippel-Lindau Tumor Suppressor Protein | 2016 |
Establishment of a Refined Oral Glucose Tolerance Test in Pigs, and Assessment of Insulin, Glucagon and Glucagon-Like Peptide-1 Responses.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Insulin | 2016 |
Glucagon responses to exercise-induced hypoglycaemia are improved by somatostatin receptor type 2 antagonism in a rat model of diabetes.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Disease Models, Animal; Glucagon; Glucose; Hypoglycemia; Insulin; Liver; Male; Peptides, Cyclic; Physical Conditioning, Animal; Rats; Rats, Sprague-Dawley; Receptors, Somatostatin | 2016 |
Blockade of glucagon signaling prevents or reverses diabetes onset only if residual β-cells persist.
Topics: Animals; Diabetes Mellitus, Experimental; Gastrointestinal Agents; Glucagon; Insulin; Insulin-Secreting Cells; Mice; Mice, Knockout; Receptors, Glucagon; Signal Transduction | 2016 |
Plasticity and Aggregation of Juvenile Porcine Islets in Modified Culture: Preliminary Observations.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucagon; Immunohistochemistry; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Islets of Langerhans Transplantation; Ki-67 Antigen; Mice; Mice, Nude; Microscopy, Confocal; Organ Culture Techniques; Oxygen Consumption; Pancreas; Swine; Transplantation, Heterologous | 2016 |
Can somatostatin antagonism prevent hypoglycaemia during exercise in type 1 diabetes?
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Disease Models, Animal; Glucagon; Glucose; Hypoglycemia; Insulin; Liver; Male; Peptides, Cyclic; Physical Conditioning, Animal; Rats; Rats, Sprague-Dawley; Receptors, Somatostatin | 2016 |
The glucoregulatory response to high-intensity aerobic exercise following training in rats with insulin-treated type 1 diabetes mellitus.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Epinephrine; Glucagon; Glycogen; Insulin; Liver; Male; Physical Conditioning, Animal; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic; Sedentary Behavior | 2016 |
Disrupted Leptin Signaling in the Lateral Hypothalamus and Ventral Premammillary Nucleus Alters Insulin and Glucagon Secretion and Protects Against Diet-Induced Obesity.
Topics: Animals; Arcuate Nucleus of Hypothalamus; Blood Glucose; Diabetes Mellitus, Experimental; Diet, High-Fat; Glucagon; Hypothalamic Area, Lateral; Hypothalamus; Insulin; Insulin Secretion; Leptin; Mice; Mice, Knockout; Neurons; Obesity; Receptors, Leptin; Signal Transduction; Ventromedial Hypothalamic Nucleus | 2016 |
CART is overexpressed in human type 2 diabetic islets and inhibits glucagon secretion and increases insulin secretion.
Topics: Animals; Blotting, Western; Calcium Signaling; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Electrophysiology; Exocytosis; Female; Glucagon; Glucagon-Secreting Cells; Glucose; Homeostasis; Humans; Immunohistochemistry; In Situ Hybridization; Insulin; Insulin Secretion; Insulin-Secreting Cells; Islets of Langerhans; Male; Mice; Mice, Inbred C57BL; Middle Aged; Nerve Tissue Proteins; Real-Time Polymerase Chain Reaction | 2016 |
Jiangtang Xiaozhi Recipe () prevents diabetic retinopathy in streptozotocin-induced diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Drugs, Chinese Herbal; Fasting; Feeding Behavior; Glucagon; Glycated Hemoglobin; Insulin; Pancreas; Rats, Sprague-Dawley; Retinal Vessels; Streptozocin | 2017 |
Dogfish glucagon analogues counter hyperglycaemia and enhance both insulin secretion and action in diet-induced obese diabetic mice.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diet, High-Fat; Dogfish; Glucagon; Glucose Tolerance Test; Hyperglycemia; Insulin; Insulin Resistance; Insulin Secretion; Insulin-Secreting Cells; Male; Mice; Mice, Obese; Obesity | 2016 |
Formononetin exhibits anti-hyperglycemic activity in alloxan-induced type 1 diabetic mice.
Topics: Alloxan; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Disease Models, Animal; Glucagon; Hypoglycemic Agents; Insulin; Islets of Langerhans; Isoflavones; Liver; Liver Glycogen; Male; Mice | 2017 |
Activation of GPR119 Stimulates Human β-Cell Replication and Neogenesis in Humanized Mice with Functional Human Islets.
Topics: Acids, Heterocyclic; Animals; Cell Proliferation; Diabetes Mellitus, Experimental; Glucagon; Insulin; Insulin-Secreting Cells; Islets of Langerhans; Mice; Oxadiazoles; Receptors, G-Protein-Coupled; Regeneration | 2016 |
Timed Inhibition of Orexin System by Suvorexant Improved Sleep and Glucose Metabolism in Type 2 Diabetic db/db Mice.
Topics: Adipose Tissue; Animals; Azepines; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Energy Metabolism; Glucagon; Glucose; Hypoglycemic Agents; Liver; Male; Mice; Mice, Inbred C57BL; Orexin Receptor Antagonists; Orexins; Receptors, Leptin; Sleep; Triazoles; Triglycerides; Wakefulness | 2016 |
Effect of Diabetes on Circulating Pancreatic Hormones in Pregnant Rats and Their Offspring.
Topics: Animals; Animals, Newborn; Biomarkers; Diabetes Mellitus, Experimental; Female; Glucagon; Insulin; Pancreatic Hormones; Pregnancy; Rats; Rats, Wistar; Somatostatin | 2016 |
Heparanase Overexpression Induces Glucagon Resistance and Protects Animals From Chemically Induced Diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Fibroblast Growth Factors; Glucagon; Glucagon-Like Peptide 1; Glucuronidase; Hyperglycemia; Insulin; Islets of Langerhans; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Streptozocin | 2017 |
Glucagon receptor inhibition normalizes blood glucose in severe insulin-resistant mice.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucagon; Glucagon-Secreting Cells; Humans; Hyperglycemia; Insulin; Insulin Resistance; Insulin-Secreting Cells; Ketosis; Mice; Mutation; Peptides; Receptor, Insulin; Receptors, Glucagon | 2017 |
Effects of a Novel Glucokinase Activator, HMS5552, on Glucose Metabolism in a Rat Model of Type 2 Diabetes Mellitus.
Topics: Animals; Blood Glucose; Carbohydrate Metabolism; Cholesterol; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucagon; Glucokinase; Glucose Tolerance Test; Insulin; Insulin Resistance; Male; Rats; Rats, Sprague-Dawley; Triglycerides | 2017 |
β-Cell Inactivation of
Topics: Adipokines; Animals; Apoptosis; Blood Glucose; Diabetes Mellitus, Experimental; Diet, High-Fat; Gene Expression Profiling; Glucagon; Glucagon-Like Peptide 1; Glucose; Glucose Tolerance Test; Incretins; Insulin; Insulin Resistance; Insulin Secretion; Insulin-Secreting Cells; Male; Mice, Knockout; Oxadiazoles; Pyrimidines; Receptors, G-Protein-Coupled | 2017 |
Paracrine GABA and insulin regulate pancreatic alpha cell proliferation in a mouse model of type 1 diabetes.
Topics: Animals; Blood Glucose; Cell Proliferation; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Glucagon; Glucagon-Secreting Cells; Male; Mice; Mice, Inbred C57BL; Muscimol | 2017 |
Discovery of potent, orally active benzimidazole glucagon receptor antagonists.
Topics: Administration, Oral; Animals; Benzimidazoles; Chemistry, Pharmaceutical; CHO Cells; Cricetinae; Cricetulus; Diabetes Mellitus, Experimental; Glucagon; Humans; Inhibitory Concentration 50; Macaca mulatta; Mice; Mice, Transgenic; Receptors, Glucagon | 2008 |
Amplification of pulsatile glucagon counterregulation by switch-off of alpha-cell-suppressing signals in streptozotocin-treated rats.
Topics: Algorithms; Animals; Blood Glucose; Data Interpretation, Statistical; Diabetes Mellitus, Experimental; Feedback, Physiological; Glucagon; Glucagon-Secreting Cells; Half-Life; Hormone Antagonists; Insulin-Secreting Cells; Male; Models, Statistical; Rats; Rats, Wistar; Signal Transduction; Somatostatin | 2008 |
Newly weaned nonobese diabetic mice show heightened early diabetes sensitivity to multiple low doses of streptozotocin than nondiabetes-prone CD-1 mice: initial beta-cell damage a key trigger for type 1 diabetes?
Topics: Age Factors; Animals; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Female; Glucagon; Glucagon-Secreting Cells; Glucose Transporter Type 2; Immunohistochemistry; Insulin; Insulin-Secreting Cells; Islets of Langerhans; Macrophages; Mice; Mice, Inbred NOD; Severity of Illness Index; Somatostatin; Somatostatin-Secreting Cells; Species Specificity; Streptozocin; Weaning | 2008 |
Prep1 deficiency induces protection from diabetes and increased insulin sensitivity through a p160-mediated mechanism.
Topics: Animals; Blood Glucose; Carrier Proteins; Diabetes Mellitus, Experimental; DNA-Binding Proteins; Female; Glucagon; Glucose Tolerance Test; Glucose Transporter Type 4; Homeodomain Proteins; Homeostasis; Humans; Insulin; Islets of Langerhans; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Muscle, Skeletal; Nuclear Proteins; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Phenotype; Pre-B-Cell Leukemia Transcription Factor 1; RNA-Binding Proteins; Signal Transduction; Trans-Activators; Transcription Factors | 2008 |
Transplantation of PC1/3-Expressing alpha-cells improves glucose handling and cold tolerance in leptin-resistant mice.
Topics: Animals; Body Composition; Cells, Cultured; Cold Temperature; Diabetes Mellitus, Experimental; Glucagon; Glucagon-Secreting Cells; Glucose; Leptin; Mice; Proglucagon; Proprotein Convertase 1; Proprotein Convertase 2 | 2009 |
Islet alpha cell number is maintained in microencapsulated islet transplantation.
Topics: Animals; Blood Glucose; Capsules; Cell Count; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; DNA; Glucagon; Glucagon-Secreting Cells; Hyperglycemia; Insulin; Insulin-Secreting Cells; Islets of Langerhans Transplantation; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL | 2008 |
Restoration of hepatic glucokinase expression corrects hepatic glucose flux and normalizes plasma glucose in zucker diabetic fatty rats.
Topics: Adenoviridae; Aging; Animals; Blood Glucose; Blotting, Western; Body Weight; Carrier Proteins; Diabetes Mellitus, Experimental; Glucagon; Glucokinase; Glucose; Hyperglycemia; Insulin; Liver; Male; Rats; Rats, Zucker | 2009 |
Chronic administration of voglibose, an alpha-glucosidase inhibitor, increases active glucagon-like peptide-1 levels by increasing its secretion and decreasing dipeptidyl peptidase-4 activity in ob/ob mice.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Dose-Response Relationship, Drug; Gene Expression; Glucagon; Glucagon-Like Peptide 1; Glycoside Hydrolase Inhibitors; Hypoglycemic Agents; Inositol; Intestinal Mucosa; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity; Time Factors | 2009 |
Combinations of growth factors enhance the potency of islets in vitro.
Topics: Animals; Blood Glucose; Cell Culture Techniques; Cell Proliferation; Diabetes Mellitus, Experimental; Epidermal Growth Factor; Female; Glucagon; Hepatocyte Growth Factor; Immunohistochemistry; Insulin; Insulin-Secreting Cells; Islets of Langerhans Transplantation; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Microscopy, Confocal; Rats; Rats, Sprague-Dawley; Somatostatin; Time Factors; Transplantation, Heterologous | 2009 |
Insulin signaling in alpha cells modulates glucagon secretion in vivo.
Topics: Animals; Arginine; Diabetes Mellitus, Experimental; Fasting; Feeding Behavior; Gene Expression Regulation; Glucagon; Glucagon-Secreting Cells; Glucose Intolerance; Hyperinsulinism; Hypoglycemia; Insulin; Insulin-Secreting Cells; Mice; Mice, Knockout; Organ Size; Organ Specificity; Receptor, Insulin; Signal Transduction; Streptozocin | 2009 |
Insulin-producing cells derived from rat bone marrow and their autologous transplantation in the duodenal wall for treating diabetes.
Topics: Animals; Blood Glucose; Bone Marrow Cells; Bone Marrow Transplantation; Cell Culture Techniques; Cell Separation; Cells, Cultured; Diabetes Mellitus; Diabetes Mellitus, Experimental; Duodenum; Glucagon; Glucose Tolerance Test; Glucose Transporter Type 2; Homeodomain Proteins; Hyperglycemia; Insulin; Insulin Secretion; Intestinal Mucosa; Rats; Transplantation, Autologous; Treatment Outcome | 2009 |
Seeding of pancreatic islets into prevascularized tissue engineering chambers.
Topics: Animals; Blood Glucose; Blood Vessels; Diabetes Mellitus, Experimental; Fasting; Glucagon; Glucose Tolerance Test; In Situ Nick-End Labeling; Insulin; Islets of Langerhans; Islets of Langerhans Transplantation; Mice; Mice, Inbred C57BL; Neovascularization, Physiologic; Somatostatin; Tissue Engineering; Tissue Survival | 2009 |
Uncoupling protein 2 regulates reactive oxygen species formation in islets and influences susceptibility to diabetogenic action of streptozotocin.
Topics: Animals; Diabetes Mellitus, Experimental; Glucagon; Glucagon-Secreting Cells; Hyperglycemia; Insulin; Insulin Secretion; Insulin-Secreting Cells; Ion Channels; Male; Mice; Mice, Knockout; Mitochondrial Proteins; Reactive Oxygen Species; Streptozocin; Uncoupling Protein 2 | 2009 |
The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Cell Differentiation; Diabetes Mellitus, Experimental; Glucagon; Glucagon-Secreting Cells; Homeodomain Proteins; Insulin-Secreting Cells; Islets of Langerhans; Mice; Nerve Tissue Proteins; Paired Box Transcription Factors; Pancreas; Stem Cells | 2009 |
Bioengineering of a functional sheet of islet cells for the treatment of diabetes mellitus.
Topics: Animals; Cell Adhesion Molecules; Cell Transplantation; Diabetes Mellitus, Experimental; Extracellular Matrix; Glucagon; Insulin; Insulin Secretion; Islets of Langerhans; Islets of Langerhans Transplantation; Kalinin; Male; Microscopy, Electron; Rats; Rats, Inbred Lew; Temperature; Time Factors | 2009 |
Long-term inhibition of the glucagon receptor with a monoclonal antibody in mice causes sustained improvement in glycemic control, with reversible alpha-cell hyperplasia and hyperglucagonemia.
Topics: Animals; Antibodies, Monoclonal; Blood Glucose; Diabetes Mellitus, Experimental; Glucagon; Glucagon-Secreting Cells; Glucose; Hyperglycemia; Hyperplasia; Hypoglycemia; Hypoglycemic Agents; Insulin; Male; Mice; Mice, Inbred C57BL; Obesity; Receptors, Glucagon; Tachyphylaxis | 2009 |
Inhibition of DPP-4 with sitagliptin improves glycemic control and restores islet cell mass and function in a rodent model of type 2 diabetes.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dietary Fats; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Glipizide; Glucagon; Glucagon-Like Peptide 1; Glycated Hemoglobin; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Ki-67 Antigen; Lipids; Liver; Male; Mice; Mice, Inbred ICR; Organ Size; Pyrazines; Sitagliptin Phosphate; Triazoles; Triglycerides | 2009 |
Exendin-4 and exercise improve hepatic glucose homeostasis by promoting insulin signaling in diabetic rats.
Topics: Animals; Base Sequence; Body Weight; Diabetes Mellitus, Experimental; DNA Primers; Energy Intake; Glucagon; Glucose; Homeostasis; Insulin; Liver; Male; Physical Conditioning, Animal; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction | 2010 |
ATP-sensitive K+ channel mediates the zinc switch-off signal for glucagon response during glucose deprivation.
Topics: Animals; Calcium Channels; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Female; Glucagon; Glucagon-Secreting Cells; Humans; Hypoglycemia; Insulin; Insulin Secretion; KATP Channels; Male; Mice; Mice, Inbred C57BL; Nifedipine; Rats; Signal Transduction; Zinc | 2010 |
Pancreatic network control of glucagon secretion and counterregulation.
Topics: Animals; Diabetes Mellitus, Experimental; Feedback, Physiological; Glucagon; Glucagon-Secreting Cells; Glucose; Humans; Hypoglycemia; Insulin; Insulin-Secreting Cells; Islets of Langerhans; Models, Biological; Models, Theoretical; Rats; Reproducibility of Results; Signal Transduction; Somatostatin-Secreting Cells | 2009 |
Orexin-1 receptor co-localizes with pancreatic hormones in islet cells and modulates the outcome of streptozotocin-induced diabetes mellitus.
Topics: Animals; Blotting, Western; Diabetes Mellitus, Experimental; Glucagon; Immunohistochemistry; Insulin; Islets of Langerhans; Male; Orexin Receptors; Pancreatic Hormones; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Streptozocin | 2010 |
A feasibility study of bihormonal closed-loop blood glucose control using dual subcutaneous infusion of insulin and glucagon in ambulatory diabetic swine.
Topics: Algorithms; Animals; Blood Glucose; Blood Glucose Self-Monitoring; Diabetes Mellitus, Experimental; Feasibility Studies; Glucagon; Hypoglycemic Agents; Infusions, Subcutaneous; Insulin; Monitoring, Ambulatory; Swine | 2009 |
Streptozotocin causes pancreatic beta cell failure via early and sustained biochemical and cellular alterations.
Topics: Animals; Cell Degranulation; Diabetes Mellitus, Experimental; Epinephrine; Glucagon; Hydroxyindoleacetic Acid; Hyperglycemia; In Vitro Techniques; Insulin; Insulin Secretion; Insulin-Secreting Cells; Male; Norepinephrine; Osmolar Concentration; Pancreas; Rats; Rats, Wistar; Secretory Vesicles; Streptozocin; Time Factors; Weight Loss | 2010 |
Prolonged survival and improved glycemia in BioBreeding diabetic rats after early sustained exposure to glucagon-like peptide 1.
Topics: Animals; Blood Glucose; Cell Proliferation; Diabetes Mellitus, Experimental; Female; Glucagon; Glucagon-Like Peptide 1; Humans; Implants, Experimental; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Pancreas; Rats; Rats, Inbred BB; Rats, Wistar; Transduction, Genetic | 2010 |
Glucagon-like peptide-2 receptor modulates islet adaptation to metabolic stress in the ob/ob mouse.
Topics: Adaptation, Physiological; Animals; Blood Glucose; Body Weight; Cell Proliferation; Diabetes Mellitus, Experimental; Disease Models, Animal; Glucagon; Glucagon-Like Peptide 2; Glucagon-Like Peptide-2 Receptor; Glucose Intolerance; Glucose Tolerance Test; Hypoglycemia; Insulin; Islets of Langerhans; Mice; Mice, Inbred C57BL; Mice, Knockout; Obesity; Receptors, Glucagon; Signal Transduction; Stress, Physiological; Time Factors | 2010 |
Pancreatic β-cell neogenesis by direct conversion from mature α-cells.
Topics: Age Factors; Animals; Biomarkers; Cell Proliferation; Cell Transdifferentiation; Diabetes Mellitus, Experimental; Glucagon; Glucagon-Secreting Cells; Insulin; Insulin-Secreting Cells; Lectins, C-Type; Ligation; MafB Transcription Factor; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Oncogene Proteins; Pancreatic Ducts; Phenotype; Regeneration; Time Factors | 2010 |
Raldh3 expression in diabetic islets reciprocally regulates secretion of insulin and glucagon from pancreatic islets.
Topics: 3T3-L1 Cells; Animals; Chlorocebus aethiops; COS Cells; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucagon; Insulin; Insulin Secretion; Insulin-Secreting Cells; Islets of Langerhans; Isotretinoin; Mice; Mice, Inbred C57BL; Retinal Dehydrogenase | 2010 |
Induction of insulin-producing cells derived from endometrial mesenchymal stem-like cells.
Topics: Adipocytes; Adult; Animals; Antigens, CD; Apoptosis; Blood Glucose; C-Peptide; Cell Differentiation; Chondrocytes; Diabetes Mellitus, Experimental; Down-Regulation; Endometrium; Female; Fibroblasts; Gene Expression; Glucagon; Glucose; Glutathione; Homeobox Protein Nkx-2.2; Homeodomain Proteins; Humans; Insulin; Insulin-Secreting Cells; Interleukin-1beta; Mesenchymal Stem Cells; Mice; Mice, SCID; Middle Aged; Neurons; Nuclear Proteins; Osteocytes; Reactive Oxygen Species; Spheroids, Cellular; Transcription Factors; Transplantation, Heterologous; Up-Regulation | 2010 |
Mechanism of orexin B-stimulated insulin and glucagon release from the pancreas of normal and diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Glucagon; Immunohistochemistry; Insulin; Insulin Secretion; Intracellular Signaling Peptides and Proteins; Islets of Langerhans; Male; Neuropeptides; Orexins; Propranolol; Rats; Rats, Wistar; Streptozocin | 2011 |
[Conversion of adult pancreatic alpha-cells to beta-cells in diabetic mice].
Topics: Animals; Autoimmune Diseases; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Glucagon; Glucagon-Secreting Cells; Insulin; Insulin Secretion; Insulin-Secreting Cells; Mice; Phenotype; Regeneration | 2010 |
Leptin activates a novel CNS mechanism for insulin-independent normalization of severe diabetic hyperglycemia.
Topics: Animals; Blood Glucose; Body Composition; Brain; Corticosterone; Diabetes Mellitus, Experimental; Glucagon; Glucose Tolerance Test; Hyperglycemia; Insulin; Leptin; Male; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction | 2011 |
Nesfatin-1 exerts a direct, glucose-dependent insulinotropic action on mouse islet β- and MIN6 cells.
Topics: Animals; Calcium-Binding Proteins; Cell Line; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; DNA-Binding Proteins; Glucagon; Glucose; Insulin; Insulin Secretion; Insulin-Secreting Cells; Male; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Nucleobindins; Obesity | 2011 |
Glucagon receptor knockout prevents insulin-deficient type 1 diabetes in mice.
Topics: Animals; Blood Glucose; Blotting, Western; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Enzyme-Linked Immunosorbent Assay; Fatty Acids; Glucagon; Hyperglycemia; Immunohistochemistry; Insulin; Insulin-Like Growth Factor I; Liver; Mice; Mice, Knockout; Pancreas; Radioimmunoassay; Receptors, Glucagon; Reverse Transcriptase Polymerase Chain Reaction | 2011 |
Diminished glucagon suppression after β-cell reduction is due to impaired α-cell function rather than an expansion of α-cell mass.
Topics: Animals; Blood Glucose; Cell Count; Cell Proliferation; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Down-Regulation; Glucagon; Glucagon-Secreting Cells; Glucose Tolerance Test; Infusions, Parenteral; Insulin; Insulin-Secreting Cells; Mice; Streptozocin | 2011 |
The reversal of diabetes in rat model using mouse insulin producing cells - a combination approach of tissue engineering and macroencapsulation.
Topics: Animals; Blood Glucose; Cell Differentiation; Diabetes Mellitus, Experimental; Disease Models, Animal; Fasting; Gelatin; Gene Expression Regulation; Glucagon; Glucose Tolerance Test; Insulin; Insulin-Secreting Cells; Islets of Langerhans Transplantation; Mice; Microscopy, Electron, Scanning; Polyurethanes; Povidone; Rats; Stem Cells; Tissue Engineering; Tissue Scaffolds; Tissue Survival | 2011 |
Leptin therapy reverses hyperglycemia in mice with streptozotocin-induced diabetes, independent of hepatic leptin signaling.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Enzyme-Linked Immunosorbent Assay; Glucagon; Growth Hormone; Hyperglycemia; Leptin; Liver; Male; Mice; Mice, Inbred C57BL; Postprandial Period; Receptors, Leptin; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction | 2011 |
GLP-1 analogs containing disulfide bond exhibited prolonged half-life in vivo than GLP-1.
Topics: Amino Acid Sequence; Animals; Blood Glucose; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Disulfides; Exenatide; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Glycated Hemoglobin; Half-Life; Hypoglycemic Agents; Injections, Subcutaneous; Insulin; Male; Molecular Sequence Data; Peptides; Protein Binding; Protein Stability; Rats; Venoms | 2011 |
Serum prolactin concentrations determine whether they improve or impair β-cell function and insulin sensitivity in diabetic rats.
Topics: Adiponectin; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucagon; Glucose Clamp Technique; Glucose Tolerance Test; Hydrocortisone; Insulin; Insulin Resistance; Insulin-Secreting Cells; Male; Pancreatectomy; Prolactin; Rats; Rats, Sprague-Dawley; Testosterone | 2011 |
Insulin and glucagon share the same mechanism of neuroprotection in diabetic rats: role of glutamate.
Topics: Analysis of Variance; Animals; Blood Glucose; Brain; Diabetes Mellitus, Experimental; Glucagon; Glutamic Acid; Hypoglycemic Agents; Infarction, Middle Cerebral Artery; Insulin; Male; Neuroprotective Agents; Oxaloacetic Acid; Rats; Rats, Sprague-Dawley; Time Factors | 2011 |
Chronic treatment with a glucagon receptor antagonist lowers glucose and moderately raises circulating glucagon and glucagon-like peptide 1 without severe alpha cell hypertrophy in diet-induced obese mice.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dietary Fats; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Glucagon; Glucagon-Like Peptide 1; Glucagon-Secreting Cells; Hypertrophy; In Vitro Techniques; Male; Mice; Mice, Knockout; Obesity; Receptors, Glucagon; Streptozocin | 2011 |
Preclinical applications of quantitative imaging cytometry to support drug discovery.
Topics: Animals; Cell Proliferation; Diabetes Mellitus, Experimental; Drug Evaluation, Preclinical; Glucagon; Humans; Insulin; Islets of Langerhans; Ki-67 Antigen; Laser Scanning Cytometry; Rats; Rats, Zucker; Tissue Array Analysis; Tissue Fixation; Voltage-Dependent Anion Channels | 2011 |
Anti-diabetic activity and potential mechanism of total flavonoids of Selaginella tamariscina (Beauv.) Spring in rats induced by high fat diet and low dose STZ.
Topics: Adipose Tissue; Animals; Biomarkers; Blood Glucose; Diabetes Mellitus, Experimental; Dietary Fats; Dose-Response Relationship, Drug; Flavonoids; Glucagon; Glucose Tolerance Test; Glycated Hemoglobin; Hypoglycemic Agents; Insulin; Insulin Receptor Substrate Proteins; Lipids; Liver; Male; Malondialdehyde; Muscle, Skeletal; Plant Extracts; Plants, Medicinal; PPAR gamma; Rats; Rats, Wistar; Selaginellaceae; Streptozocin; Superoxide Dismutase; Time Factors | 2011 |
Therapeutic impact of leptin on diabetes, diabetic complications, and longevity in insulin-deficient diabetic mice.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Eating; Glucagon; Hyperglycemia; Insulin; Leptin; Longevity; Mice; Mice, Transgenic; Oxidative Stress; Pancreas | 2011 |
Normal glucagon signaling and β-cell function after near-total α-cell ablation in adult mice.
Topics: Animals; Apoptosis; Cell Count; Diabetes Mellitus, Experimental; Diphtheria Toxin; Glucagon; Glucagon-Secreting Cells; Heparin-binding EGF-like Growth Factor; Hyperglycemia; Hypoglycemia; Insulin; Insulin-Secreting Cells; Intercellular Signaling Peptides and Proteins; Male; Mice; Mice, Transgenic; Pancreas; Promoter Regions, Genetic; Receptors, Glucagon; Selective Estrogen Receptor Modulators; Signal Transduction; Streptozocin; Tamoxifen | 2011 |
Normalizing action of exendin-4 and GLP-1 in the glucose metabolism of extrapancreatic tissues in insulin-resistant and type 2 diabetic states.
Topics: Adipose Tissue; Animals; Biological Transport; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Exenatide; Glucagon; Glucagon-Like Peptide 1; Glucose; Glucose Transporter Type 2; Glucose Transporter Type 4; Glycogen Synthase; Insulin Resistance; Liver; Male; Mitogen-Activated Protein Kinases; Muscle, Skeletal; Peptides; Phosphatidylinositol 3-Kinases; Rats; Rats, Wistar; Venoms | 2012 |
Metabolic function of a suboptimal transplanted islet mass in nonhuman primates on rapamycin monotherapy.
Topics: Animals; Arginine; Blood Glucose; C-Peptide; Diabetes Mellitus, Experimental; Glucagon; Glucose Tolerance Test; Immunosuppressive Agents; Insulin; Insulin-Secreting Cells; Islets of Langerhans Transplantation; Macaca fascicularis; Sirolimus | 2012 |
Somatostatin receptor type 2 antagonism improves glucagon and corticosterone counterregulatory responses to hypoglycemia in streptozotocin-induced diabetic rats.
Topics: Animals; Blood Glucose; Corticosterone; Cytoprotection; Diabetes Mellitus, Experimental; Glucagon; Glucose; Hormone Antagonists; Hypoglycemia; Male; Peptides, Cyclic; Rats; Rats, Sprague-Dawley; Receptors, Somatostatin; Streptozocin; Time Factors | 2012 |
Evidence of endoplasmic reticulum stress mediating cell death in transplanted human islets.
Topics: Activating Transcription Factor 6; Animals; Apoptosis; Caspase 3; Diabetes Mellitus, Experimental; DNA-Binding Proteins; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Eukaryotic Initiation Factor-2; Glucagon; Heat-Shock Proteins; Humans; Insulin; Islets of Langerhans; Islets of Langerhans Transplantation; Male; Mice; Mice, Nude; Mitogen-Activated Protein Kinase 8; Regulatory Factor X Transcription Factors; Transcription Factor CHOP; Transcription Factors; X-Box Binding Protein 1 | 2012 |
Ectopic expression of glucagon receptor in skeletal muscles improves glucose homeostasis in a mouse model of diabetes.
Topics: Animals; Blood Glucose; Creatine Kinase, MM Form; Diabetes Mellitus, Experimental; Female; Fructose-Bisphosphatase; Glucagon; Glucose-6-Phosphatase; Insulin; Insulin-Secreting Cells; Liver; Male; Mice; Mice, Transgenic; Muscle, Skeletal; Promoter Regions, Genetic; Receptors, Glucagon | 2012 |
Exendin-4 ameliorates diabetic symptoms through activation of glucokinase.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Enzyme Activation; Exenatide; Glucagon; Glucagon-Like Peptide 1; Glucokinase; Hypoglycemic Agents; Insulin; Male; Mice; Mice, Inbred C57BL; Peptides; Venoms | 2012 |
MK-626, a dipeptidyl peptidase-4 inhibitor, does not improve the hyperglycemia or hyperinsulinemia of nonobese diabetic MKR mice.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Dipeptidyl-Peptidase IV Inhibitors; Glucagon; Glucose; Glucose Intolerance; Homeostasis; Hyperglycemia; Hyperinsulinism; Incretins; Insulin; Insulin Secretion; Islets of Langerhans; Male; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; Mice, Obese; Phenylalanine; Triazoles | 2012 |
Regeneration of pancreatic non-β endocrine cells in adult mice following a single diabetes-inducing dose of streptozotocin.
Topics: Animals; Cell Count; Cell Proliferation; Diabetes Mellitus, Experimental; Disease Models, Animal; Dose-Response Relationship, Drug; Glucagon; Glucagon-Secreting Cells; Homeodomain Proteins; Insulin; Insulin-Secreting Cells; Islets of Langerhans; Mice; Mice, Inbred C57BL; Regeneration; Somatostatin; Somatostatin-Secreting Cells; Streptozocin; Trans-Activators | 2012 |
Antidiabetic activities of oligosaccharides of Ophiopogonis japonicus in experimental type 2 diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Fasting; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Glycogen; Hypoglycemic Agents; Liver; Male; Muscle, Skeletal; Oligosaccharides; Ophiopogon; Organ Size; Proteinuria; Rats; Rats, Sprague-Dawley | 2012 |
Metabolic manifestations of insulin deficiency do not occur without glucagon action.
Topics: Adenoviridae; Animals; Blood Glucose; Chromatography, Gas; Cyclic AMP Response Element-Binding Protein; Diabetes Mellitus, Experimental; DNA Primers; Enzyme-Linked Immunosorbent Assay; Genetic Vectors; Glucagon; Immunoblotting; Insulin; Liver; Mass Spectrometry; Mice; Mice, Inbred C57BL; Mice, Knockout; Real-Time Polymerase Chain Reaction; Receptors, Glucagon | 2012 |
In vivo hyperpolarized carbon-13 magnetic resonance spectroscopy reveals increased pyruvate carboxylase flux in an insulin-resistant mouse model.
Topics: Animals; Aspartic Acid; Carbon Isotopes; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Glucagon; Gluconeogenesis; Insulin Resistance; Liver; Magnetic Resonance Spectroscopy; Malates; Male; Mice; Mice, Inbred C57BL; Pyruvate Carboxylase; Pyruvic Acid | 2013 |
Additive effects of cilnidipine and angiotensin II receptor blocker in preventing the progression of diabetic nephropathy in diabetic spontaneously hypertensive rats.
Topics: Amlodipine; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Biomarkers; Blood Glucose; Blood Pressure; Calcium Channel Blockers; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Dihydropyridines; Disease Progression; Drug Therapy, Combination; Glomerulonephritis; Glucagon; Glucose Transporter Type 1; Glycated Hemoglobin; Glycogen; Hypertension; Kidney; Male; Norepinephrine; Proteinuria; Rats; Rats, Inbred SHR; Renin-Angiotensin System; Tetrazoles; Transforming Growth Factor beta1; Valine; Valsartan | 2013 |
In situ electrophysiological examination of pancreatic α cells in the streptozotocin-induced diabetes model, revealing the cellular basis of glucagon hypersecretion.
Topics: Action Potentials; Animals; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Electrophysiological Phenomena; Exocytosis; Glucagon; Glucagon-Secreting Cells; Glucose Intolerance; Hyperglycemia; Mice; Potassium Channels, Voltage-Gated; Secretory Vesicles; Voltage-Gated Sodium Channels | 2013 |
Chemical cholecystokinin receptor activation protects against obesity-diabetes in high fat fed mice and has sustainable beneficial effects in genetic ob/ob mice.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Dietary Fats; Eating; Glucagon; Glucose Tolerance Test; Insulin; Insulin Resistance; Lipids; Mice; Mice, Obese; Obesity; Pancreas; Receptors, Cholecystokinin; Sincalide | 2013 |
The role of clusterin on pancreatic beta cell regeneration after exendin-4 treatment in neonatal streptozotocin administrated rats.
Topics: Animals; Animals, Newborn; Biomarkers; Blood Glucose; Body Weight; Cell Proliferation; Clusterin; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Exenatide; Gene Expression; Glucagon; Homeodomain Proteins; Hypoglycemic Agents; In Situ Hybridization; Insulin-Secreting Cells; Peptides; Rats; Rats, Wistar; Regeneration; RNA, Messenger; Trans-Activators; Venoms | 2013 |
Effects of electroacupuncture at weiwanxiashu and zusanli points on blood glucose and plasma pancreatic glucagon contents in diabetic rabbits.
Topics: Acupuncture Points; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Electroacupuncture; Female; Glucagon; Male; Rabbits | 2002 |
Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis.
Topics: Animals; Apoptosis; beta Catenin; Blood Glucose; Cell Line; Cell Survival; Colforsin; Cricetinae; Cycloheximide; Cytokines; Cytoskeletal Proteins; Diabetes Mellitus, Experimental; Exenatide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose Tolerance Test; In Situ Nick-End Labeling; Insulin; Islets of Langerhans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Peptide Fragments; Peptides; Protein Precursors; Protein Synthesis Inhibitors; Rats; Rats, Wistar; Receptors, Glucagon; Signal Transduction; Streptozocin; Trans-Activators; Venoms | 2003 |
Growth inhibitors promote differentiation of insulin-producing tissue from embryonic stem cells.
Topics: Androstadienes; Animals; Biomarkers; Cell Aggregation; Cell Differentiation; Cell Line; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Embryo, Mammalian; Enzyme Inhibitors; Glucagon; Growth Inhibitors; Homeostasis; Insulin; Insulin Secretion; Islets of Langerhans; Male; Mice; Mice, Inbred NOD; Mice, SCID; Neoplasms, Experimental; Niacinamide; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Stem Cell Transplantation; Stem Cells; Streptozocin; Weight Loss; Wortmannin | 2002 |
[Impact of islet alpha cell loss on insulin secretion].
Topics: Animals; Cell Count; Diabetes Mellitus, Experimental; Glucagon; Glucose; Humans; Immunohistochemistry; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Islets of Langerhans Transplantation; Mice; Mice, Inbred C57BL; Time Factors; Transplantation, Heterologous | 2002 |
Expression of Pax4 in embryonic stem cells promotes differentiation of nestin-positive progenitor and insulin-producing cells.
Topics: Animals; Cell Differentiation; Cell Line; Diabetes Mellitus, Experimental; DNA, Complementary; Embryo, Mammalian; Enzyme-Linked Immunosorbent Assay; Genetic Vectors; Glucagon; Glucose; Glucose Transporter Type 2; Homeodomain Proteins; Immunoassay; Immunohistochemistry; Insulin; Intermediate Filament Proteins; Male; Mice; Mice, Inbred BALB C; Microscopy, Electron; Microscopy, Fluorescence; Monosaccharide Transport Proteins; Nerve Tissue Proteins; Nestin; Paired Box Transcription Factors; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stem Cell Transplantation; Stem Cells; Time Factors; Transcription Factors | 2003 |
Xenogeneic milieu markedly remodels endocrine cell populations after transplantation of fish islets into streptozotocin-diabetic nude mice.
Topics: Animals; Diabetes Mellitus, Experimental; Glucagon; Graft Survival; Immunohistochemistry; Insulin; Islets of Langerhans; Islets of Langerhans Transplantation; Kidney; Male; Mice; Mice, Nude; Models, Animal; Somatostatin; Tilapia; Transplantation, Heterologous | 2003 |
Dipeptidyl peptidase IV inhibitor treatment stimulates beta-cell survival and islet neogenesis in streptozotocin-induced diabetic rats.
Topics: Animals; Blood Glucose; Cell Count; Cell Differentiation; Cell Division; Cell Survival; Diabetes Mellitus, Experimental; Dipeptidyl Peptidase 4; Eating; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose Tolerance Test; Immunohistochemistry; Insulin; Insulin Secretion; Islets of Langerhans; Lipids; Liver; Male; Peptide Fragments; Phosphoenolpyruvate Carboxykinase (GTP); Protease Inhibitors; Protein Precursors; Rats; Rats, Wistar; Weight Gain | 2003 |
Glucagon-like peptide 1 content of intestinal tract in adult rats injected with streptozotocin either during neonatal period or 7 d before sacrifice.
Topics: Animals; Animals, Newborn; Blood Glucose; Body Weight; Cecum; Colon; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Female; Glucagon; Glucagon-Like Peptide 1; Ileum; Insulin; Intestines; Jejunum; Male; Pancreas; Peptide Fragments; Protein Precursors; Proteins; Rats; Rats, Inbred BB; Rats, Wistar; Streptozocin | 2002 |
Enhanced adrenergic mechanisms in glucose output from the kidney of diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Epinephrine; Glucagon; Glucose; Glutamine; Glycerol; Hydrocortisone; Kidney; Male; Nephrectomy; Rats; Rats, Wistar; Sympathetic Nervous System | 2003 |
Effects of prolonged exendin-4 administration on entero-insular axis of normal and streptozotocin-induced diabetic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Exenatide; Female; Glucagon; Glucagon-Like Peptide-1 Receptor; Insulin; Insulin Secretion; Islets of Langerhans; Leptin; Liver Glycogen; Peptide Fragments; Peptides; Rats; Rats, Wistar; Receptors, Glucagon; Venoms | 2003 |
Effects of preproglucagon-derived peptides and exendins on steroid-hormone secretion from dispersed adrenocortical cells of normal and streptozotocin-induced diabetic rats.
Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Animals; Diabetes Mellitus, Experimental; Glucagon; Peptides; Proglucagon; Protein Precursors; Rats; Steroids | 2003 |
A rapid survey of the literature indicates that most of the studies performed on isolated islets from rat, mice, or human pancreas dealt with culture conditions and secretion of the different hormones.
Topics: Animals; Diabetes Mellitus, Experimental; Glucagon; Humans; In Vitro Techniques; Insulin; Islets of Langerhans; Mice; Microscopy, Confocal; Rats; Somatostatin | 2003 |
[Short-term effects of cyclosporine A on the function of pancreatic islet cells in normal and spontaneous diabetic Chinese hamsters].
Topics: Animals; Cells, Cultured; Cricetinae; Cyclosporine; Diabetes Mellitus, Experimental; Glucagon; Immunosuppressive Agents; Insulin; Insulin Secretion; Islets of Langerhans | 2003 |
Hyperglycemia-glycogenolytic factor in diabetic man and alloxan-diabetic animals.
Topics: Alloxan; Animals; Diabetes Mellitus; Diabetes Mellitus, Experimental; Glucagon; Humans; Hyperglycemia; Male | 1952 |
Diabetogenic action of pancreatic glucagon.
Topics: Animals; Diabetes Mellitus, Experimental; Glucagon; Hormones; Pancreas; Pancreatic Hormones | 1954 |
Glycogen stores in glucagon-treated rats. II. Effect of alloxan diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Glucagon; Glycogen; Glycogenolysis; Hormones; Pancreas; Pancreatic Hormones; Rats | 1956 |
[Action of insulin and glucagon liver perfusion of frogs, rabbits and dogs, both normal and alloxanic diabetic].
Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Glucagon; Insulin; Liver; Perfusion; Rabbits | 1956 |
[Effect of N1-sulfanilyl-N2-n-butyl carbamide on the progress of alloxan diabetes in rabbits and on the glucagon content in dogs pancreas].
Topics: Animals; Diabetes Mellitus, Experimental; Dogs; Glucagon; Pancreas; Rabbits; Sulfanilamide; Sulfanilamides; Urea | 1956 |
Changes in dogs devoid of A cells.
Topics: Animals; Diabetes Mellitus, Experimental; Dogs; Glucagon; Humans; Islets of Langerhans | 1957 |
The preventive effect of glucagon (HGF) against the diabetogenic action of alloxan and its antagonism by insulin.
Topics: Alloxan; Animals; Diabetes Mellitus, Experimental; Glucagon; Insulin | 1957 |
[Effects of glucagon on normal, starving and pancreas-diabetic dogs].
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Electrolytes; Epinephrine; Glucagon; Humans; Pancreas | 1957 |
[Effect of N1-sulfanilylo-N2-n-butylcarbamide on course of alloxan diabetes in rabbits and on hyperglycemic factor (glucagon) in pancreatic extracts in dogs].
Topics: Animals; Carbutamide; Diabetes Mellitus, Experimental; Dogs; Glucagon; Humans; Hypoglycemic Agents; Pancreatic Extracts; Rabbits | 1957 |
Endocrine influences of the pancreas on gastric secretion. I. The effects of glucagon and alloxan on Heidenhain pouch secretion.
Topics: Abdominal Wall; Alloxan; Animals; Diabetes Mellitus, Experimental; Gastric Juice; Glucagon; Pancreas | 1958 |
Effect of glucagon on the serum inorganic phosphorus of normal and diabetic dogs.
Topics: Animals; Diabetes Mellitus, Experimental; Dogs; Glucagon; Humans; Phosphorus | 1961 |
[EXPERIMENTAL DIABETES].
Topics: Animals; Antimetabolites; Diabetes Mellitus; Diabetes Mellitus, Experimental; Enzymes; Glucagon; Hormones; Insulin Antibodies; Pancreas; Research | 1963 |
METABOLIC AND HORMONAL CONTROL OF PHOSPHOENOLPYRUVATE CARBOXYKINASE AND MALIC ENZYME IN RAT LIVER.
Topics: Adrenal Cortex Hormones; Adrenalectomy; Animals; Corticosterone; Cortisone; Diabetes Mellitus, Experimental; Fasting; Glucagon; Glucose; Hydrocortisone; Insulin; Lactates; Liver; Malates; NADP; Phosphoenolpyruvate; Phosphoenolpyruvate Carboxykinase (ATP); Phosphoenolpyruvate Carboxylase; Phosphotransferases; Rats; Research | 1963 |
[ON QUANTITATIVE STUDIES OF THE GLYCOGEN CONTENT OF THE LIVER IN HEALTHY AND DISEASED SUBJECTS. 3. ACTION MECHANISM OF GLUCAGON].
Topics: Animals; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Experimental; Glucagon; Glycogen; Humans; Hyperglycemia; Insulin; Liver; Liver Glycogen; Pharmacology; Rabbits | 1965 |
DECREASE IN THE CONCENTRATIONS OF KETONE BODIES AND FREE FATTY ACIDS IN RAT BLOOD IN RESPONSE TO A GLUCOSE LOAD: ITS POSSIBLE RELATION TO ENDOGENOUS INSULIN ACTIVITY.
Topics: Acidosis; Adrenalectomy; Animals; Blood Chemical Analysis; Blood Glucose; Diabetes Mellitus, Experimental; Epinephrine; Fatty Acids; Fatty Acids, Nonesterified; Glucagon; Glucose; Guinea Pigs; Insulin; Ketone Bodies; Lipid Metabolism; Pancreas; Pancreatectomy; Pharmacology; Rats; Research; Surgical Procedures, Operative; Tolbutamide | 1965 |
THE EFFECT OF GLUCAGON ON BLOOD SUGAR AND INORGANIC PHOSPHORUS LEVELS IN NORMATHERMIC AND HYPOTHERMIC RATS.
Topics: Animals; Biological Transport; Blood Glucose; Diabetes Mellitus, Experimental; Epinephrine; Fluids and Secretions; Glucagon; Hypothermia; Hypothermia, Induced; Pharmacology; Phosphates; Phosphorus; Rats; Research; Urine | 1965 |
THE EFFECT OF DIFFERENT HORMONAL CONDITIONS ON THE CONCENTRATION AND OXIDOREDUCTION STATE OF THE NICOTINAMIDE NUCLEOTIDES OF RAT LIVER.
Topics: Adrenalectomy; Animals; Carbohydrate Metabolism; Cortisone; Diabetes Mellitus, Experimental; Glucagon; Glucose; Glucosephosphate Dehydrogenase; Growth Hormone; Lipid Metabolism; Liver; NAD; NADP; Niacinamide; Nucleotides; Oxidation-Reduction; Oxidoreductases; Pharmacology; Phosphogluconate Dehydrogenase; Rats; Research; Toxicology | 1965 |
INFLUENCE OF PANCREATIC HORMONES ON ENZYMES CONCERNED WITH UREA SYNTHESIS IN RAT LIVER.
Topics: Amino Acids; Animals; Arginase; Argininosuccinate Lyase; Argininosuccinate Synthase; Carbon-Nitrogen Ligases; Diabetes Mellitus, Experimental; Glucagon; Insulin; Insulin, Long-Acting; Ligases; Liver; Lyases; Multienzyme Complexes; Ornithine; Ornithine Carbamoyltransferase; Pancreatic Hormones; Pharmacology; Protamines; Rats; Research; Urea | 1965 |
"Metaglucagon diabetes" in rabbits.
Topics: Animals; Diabetes Mellitus, Experimental; Glucagon; Rabbits | 1959 |
Glucose-responsive hepatic insulin gene therapy of spontaneously diabetic BB/Wor rats.
Topics: 3-Hydroxybutyric Acid; Adenoviridae; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Enzyme-Linked Immunosorbent Assay; Genetic Therapy; Glucagon; Glucose; Hepatocytes; Insulin; Lipid Metabolism; Liver; Male; Rats; Time Factors | 2003 |
Pharmacokinetics and anti-hyperglycaemic efficacy of a novel inhibitor of glycogen phosphorylase, 1,4-dideoxy-1,4-imino-d- arabinitol, in glucagon-challenged rats and dogs and in diabetic ob/ob mice.
Topics: Administration, Oral; Animals; Arabinose; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Glucagon; Glycogen Phosphorylase; Half-Life; Hypoglycemic Agents; Imino Furanoses; Injections, Intravenous; Male; Mice; Mice, Obese; Rats; Rats, Sprague-Dawley; Sugar Alcohols | 2003 |
The hyperglycemic-glycogenolytic factor produced by the pancreas.
Topics: Animals; Diabetes Mellitus, Experimental; Glucagon; Pancreas | 1952 |
[Hyperglycemic-glycogenolytic factor of the pancreas].
Topics: Animals; Diabetes Mellitus, Experimental; Glucagon; Pancreas | 1951 |
Modulation of hormone secretion by functional electrical stimulation of the intact and incompletely dysfunctional dog pancreas.
Topics: Animals; Diabetes Mellitus, Experimental; Dogs; Electric Stimulation; Electrodes, Implanted; Glucagon; Insulin; Insulin Secretion; Pancreas; Radioimmunoassay; Splanchnic Nerves; Vagus Nerve | 2004 |
Regulation of alpha-cell function by the beta-cell during hypoglycemia in Wistar rats: the "switch-off" hypothesis.
Topics: Animals; Arteries; Diabetes Mellitus, Experimental; Drug Administration Schedule; Duodenum; Glucagon; Hypoglycemia; Injections, Intra-Arterial; Insulin; Islets of Langerhans; Male; Models, Biological; Pancreas; Rats; Rats, Wistar | 2004 |
Regulation of alpha-cell function by the beta-cell in isolated human and rat islets deprived of glucose: the "switch-off" hypothesis.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Diabetes Mellitus, Experimental; Drug Administration Schedule; Glucagon; Glucose; Humans; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Models, Biological; Rats | 2004 |
Long-term correction of hyperglycemia in diabetic mice after implantation of cultured human cells derived from fetal pancreas.
Topics: Animals; Biomarkers; Cell Differentiation; Cell Separation; Clone Cells; Diabetes Mellitus, Experimental; Fetal Tissue Transplantation; Glucagon; Humans; Hyperglycemia; Insulin; Intermediate Filament Proteins; Islets of Langerhans; Keratins; Mice; Mice, SCID; Nerve Tissue Proteins; Nestin; Pancreas; Polylysine; Stem Cell Transplantation; Streptozocin; Transplantation, Heterologous; Vimentin | 2004 |
Nicorandil improves diabetes and rat islet beta-cell damage induced by streptozotocin in vivo and in vitro.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Free Radical Scavengers; Glucagon; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Nicorandil; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Rats; Rats, Inbred BN; Reactive Oxygen Species; Superoxides; Vasodilator Agents | 2004 |
The role of arginine vasopressin in diabetes-associated increase in glucagon secretion.
Topics: Animals; Arginine Vasopressin; Diabetes Mellitus, Experimental; Glucagon; In Vitro Techniques; Insulin; Male; Pancreas; Perfusion; Rats; Rats, Sprague-Dawley | 2004 |
Insulin stimulates and diabetes inhibits O-linked N-acetylglucosamine transferase and O-glycosylation of Sp1.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Diabetes Mellitus, Experimental; Glucagon; Glycosylation; Insulin; Kinetics; Liver Neoplasms; Male; N-Acetylglucosaminyltransferases; Rats; Rats, Sprague-Dawley; Sp1 Transcription Factor | 2004 |
Reduction of beta cell mass: partial insulin secretory compensation from the residual beta cell population in the nicotinamide-streptozotocin Göttingen minipig after oral glucose in vivo and in the perfused pancreas.
Topics: Animals; Area Under Curve; Blood Glucose; Diabetes Mellitus, Experimental; Disease Models, Animal; Dose-Response Relationship, Drug; Fasting; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Male; Niacinamide; Pancreas; Peptide Fragments; Perfusion; Protein Precursors; Reference Values; Swine; Swine, Miniature | 2004 |
[Studies on anti-hyperglycemic effect and its mechanism of Dendrobium candidum].
Topics: Animals; Blood Glucose; Dendrobium; Diabetes Mellitus, Experimental; Drugs, Chinese Herbal; Epinephrine; Female; Glucagon; Glycogen; Hypoglycemia; Hypoglycemic Agents; Insulin; Islets of Langerhans; Liver; Male; Mice; Plants, Medicinal; Rats; Rats, Sprague-Dawley | 2004 |
Effect of glucagon-like peptide-1(7-36) and exendin-4 on the vascular reactivity in streptozotocin/nicotinamide-induced diabetic rats.
Topics: Animals; Aorta, Thoracic; Blood Glucose; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Exenatide; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Oxidative Stress; Peptide Fragments; Peptides; Rats; Rats, Wistar; Streptozocin; Vasodilator Agents; Venoms | 2005 |
Caspase-3-dependent beta-cell apoptosis in the initiation of autoimmune diabetes mellitus.
Topics: Animals; Apoptosis; Caspase 3; Caspases; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Glucagon; Insulin; Islets of Langerhans; Lymphocyte Activation; Mice; Mice, Knockout; Pancrelipase; T-Lymphocytes | 2005 |
Impact of inulin and oligofructose on gastrointestinal peptides.
Topics: Animals; Diabetes Mellitus, Experimental; Dietary Fiber; Eating; Ghrelin; Glucagon; Glucagon-Like Peptide 1; Intestinal Mucosa; Inulin; Male; Oligosaccharides; Peptide Fragments; Peptide Hormones; Peptide YY; Protein Precursors; Rats; Rats, Wistar | 2005 |
Involvement of endogenous glucagon-like peptide-1(7-36) amide on glycaemia-lowering effect of oligofructose in streptozotocin-treated rats.
Topics: Actins; Animals; Blood Glucose; Colon; Diabetes Mellitus, Experimental; Eating; Fermentation; Food Deprivation; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose Tolerance Test; Insulin; Islets of Langerhans; Male; Oligosaccharides; Peptide Fragments; Proglucagon; Proprotein Convertase 1; Protein Precursors; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2005 |
Transplantation of discordant xenogeneic islets using repeated therapy with anti-CD154.
Topics: Animals; Antibodies, Monoclonal; B-Lymphocytes; CD40 Ligand; Cricetinae; Diabetes Mellitus, Experimental; Glucagon; Graft Survival; Histocompatibility Testing; Humans; Insulin; Islets of Langerhans Transplantation; Male; Mice; Mice, Inbred C57BL; T-Lymphocytes; Tissue Donors; Transplantation, Heterologous | 2005 |
Glucagon-like peptide-1 plasmid construction and delivery for the treatment of type 2 diabetes.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Genetic Vectors; Glucagon; Glucagon-Like Peptide 1; Injections, Intravenous; Insulin; Insulin Secretion; Islets of Langerhans; Male; Mice; Mice, Inbred C57BL; Peptide Fragments; Plasmids; Protein Precursors | 2005 |
Effects of glucagon-like peptide-1 and exendins on kinase activity, glucose transport and lipid metabolism in adipocytes from normal and type-2 diabetic rats.
Topics: Adipocytes; Animals; Biological Transport, Active; Deoxyglucose; Diabetes Mellitus, Experimental; Exenatide; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; In Vitro Techniques; Lipid Metabolism; Lipids; Lipolysis; Male; Peptide Fragments; Peptides; Protein Kinases; Protein Precursors; Rats; Rats, Wistar; Venoms | 2005 |
Hepatic insulin gene therapy prevents deterioration of vascular function and improves adipocytokine profile in STZ-diabetic rats.
Topics: Acetylcholine; Adenoviridae; Adiponectin; Animals; Aorta; Blood Glucose; Body Weight; Cardiovascular Physiological Phenomena; Diabetes Mellitus, Experimental; Erythrocytes; Genetic Therapy; Glucagon; Hemoglobins; Humans; In Vitro Techniques; Injections, Intravenous; Insulin; Insulin Resistance; Leptin; Lipids; Liver; Male; Nitric Oxide Synthase; Nitroprusside; Peptide Hormones; Rats; Rats, Sprague-Dawley; Vasodilation | 2006 |
FK-614, a selective peroxisome proliferator-activated receptor gamma agonist, improves peripheral glucose utilization while decreasing hepatic insulin extraction in alloxan-induced diabetic dogs.
Topics: Animals; Benzimidazoles; Blood Glucose; Blood Pressure; Diabetes Mellitus, Experimental; Dogs; Fatty Acids, Nonesterified; Glucagon; Glucose; Glucose Clamp Technique; Hyperinsulinism; Hypoglycemic Agents; Insulin; Insulin Resistance; Insulin, Isophane; Liver; Male; PPAR gamma; Tritium | 2005 |
Development of islet-like cell clusters after pancreas transplantation in the spontaneously diabetic Torri rat.
Topics: Age of Onset; Animals; Blotting, Western; Cell Nucleus; Cell Proliferation; Diabetes Mellitus, Experimental; Disease Models, Animal; Glucagon; Glucose; Glucose Tolerance Test; Homeodomain Proteins; Immunohistochemistry; Insulin; Insulin-Secreting Cells; Islets of Langerhans; Islets of Langerhans Transplantation; Ki-67 Antigen; Male; Pancreas; Pancreas Transplantation; Rats; Time Factors; Trans-Activators | 2005 |
Histopathological changes in insulin, glucagon and somatostatin cells in the islets of NOD mice during cyclophosphamide-accelerated diabetes: a combined immunohistochemical and histochemical study.
Topics: Animals; Confidence Intervals; Cyclophosphamide; Diabetes Mellitus, Experimental; Glucagon; Glucagon-Secreting Cells; Glucose Transporter Type 2; Immunohistochemistry; Insulin; Insulin-Secreting Cells; Islets of Langerhans; Mice; Mice, Inbred NOD; Somatostatin; Somatostatin-Secreting Cells; Time Factors | 2005 |
Glucagon expression shift in a syngeneic single-donor intrahepatic rat islet transplantation model.
Topics: Animals; Diabetes Mellitus, Experimental; Glucagon; Insulin; Insulin Secretion; Islets of Langerhans Transplantation; Liver; Models, Animal; Portal Vein; Rats; Rats, Inbred Lew; Transplantation, Isogeneic | 2005 |
Role of endogenous ghrelin in the hyperphagia of mice with streptozotocin-induced diabetes.
Topics: alpha-MSH; Animals; Arcuate Nucleus of Hypothalamus; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Ghrelin; Glucagon; Hyperphagia; Male; Mice; Mice, Inbred C57BL; Neuropeptide Y; Oligopeptides; Peptide Hormones; Streptozocin | 2006 |
Anti-diabetic activity of SMK001, a poly herbal formula in streptozotocin induced diabetic rats: therapeutic study.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Female; Glucagon; Glyburide; Glycosuria; Hypoglycemic Agents; Immunohistochemistry; Insulin; Organ Size; Pancreas; Plant Extracts; Rats; Rats, Sprague-Dawley | 2006 |
Ectopic expression of neurogenin 3 in neonatal pig pancreatic precursor cells induces (trans)differentiation to functional alpha cells.
Topics: Adenoviridae; Animals; Animals, Genetically Modified; Animals, Newborn; Basic Helix-Loop-Helix Transcription Factors; Cell Differentiation; Diabetes Mellitus, Experimental; DNA Primers; Glucagon; Glucagon-Secreting Cells; Green Fluorescent Proteins; Immunohistochemistry; Insulin; Islets of Langerhans Transplantation; Keratin-7; Keratins; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Swine; Synaptophysin; Transplantation, Heterologous | 2006 |
Slow acting protein extract from fruit pulp of Momordica charantia with insulin secretagogue and insulinomimetic activities.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Blood Glucose; Cell Culture Techniques; Diabetes Mellitus, Experimental; Fruit; Glucagon; Glucose; Hypoglycemic Agents; Insulin; Insulin Secretion; Male; Mice; Momordica charantia; Monocytes; Pancreas; Perfusion; Plant Extracts; Plant Proteins; Rats; Rats, Wistar; Streptozocin | 2006 |
Impact of in vivo fatty acid oxidation blockade on glucose turnover and muscle glucose metabolism during low-dose AICAR infusion.
Topics: Acetyl-CoA Carboxylase; Adenosine Monophosphate; Adenosine Triphosphate; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Epoxy Compounds; Fatty Acids; Glucagon; Glucose; Glucosephosphate Dehydrogenase; Glycogen; Hypoglycemic Agents; Insulin; Lactic Acid; Male; Multienzyme Complexes; Muscle, Skeletal; Oxidation-Reduction; Propionates; Protein Serine-Threonine Kinases; Ribonucleotides; Serine | 2006 |
Survival and function of transplanted islet cells on an in vivo, vascularized tissue engineering platform in the rat: A pilot study.
Topics: Animals; Diabetes Mellitus, Experimental; Glucagon; Graft Survival; Insulin; Islets of Langerhans; Islets of Langerhans Transplantation; Male; Neovascularization, Physiologic; Pilot Projects; Rats; Rats, Sprague-Dawley; Tissue Engineering; Transplantation, Homologous | 2006 |
Sexual dimorphism in insulin sensitivity and susceptibility to develop diabetes in rats.
Topics: Animals; Biomarkers; Blood Glucose; Body Composition; Diabetes Mellitus, Experimental; Disease Susceptibility; Female; Glucagon; Glucose Tolerance Test; Immunohistochemistry; Insulin; Insulin Resistance; Islets of Langerhans; Male; Microscopy, Confocal; Niacinamide; Rats; Rats, Wistar; Sex Characteristics | 2006 |
NR4A orphan nuclear receptors are transcriptional regulators of hepatic glucose metabolism.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; DNA-Binding Proteins; Glucagon; Gluconeogenesis; Glucose; Humans; Hyperglycemia; Liver; Male; Mice; Nuclear Receptor Subfamily 4, Group A, Member 1; Nuclear Receptor Subfamily 4, Group A, Member 2; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Transcription Factors | 2006 |
Metformin-like effect of Salvia officinalis (common sage): is it useful in diabetes prevention?
Topics: Animals; Beverages; Blood Glucose; Cells, Cultured; Diabetes Mellitus, Experimental; Female; Glucagon; Glucose; Glucose Tolerance Test; Hepatocytes; Hypoglycemic Agents; Insulin; Male; Metformin; Mice; Mice, Inbred BALB C; Phytotherapy; Plant Extracts; Rats; Rats, Wistar; Salvia officinalis | 2006 |
Oxyntomodulin increases intrinsic heart rate in mice independent of the glucagon-like peptide-1 receptor.
Topics: Animals; Autonomic Nervous System; Blood Pressure; Body Temperature; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Dopamine beta-Hydroxylase; Dose-Response Relationship, Drug; Eating; Electrocardiography; Epinephrine; Exenatide; Female; Glucagon; Glucagon-Like Peptide-1 Receptor; Heart; Heart Rate; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Norepinephrine; Oxyntomodulin; Peptides; Rats; Rats, Sprague-Dawley; Receptors, Glucagon; Telemetry; Venoms | 2007 |
Catalase expression in pancreatic alpha cells of diabetic and non-diabetic mice.
Topics: Animals; Catalase; Diabetes Mellitus, Experimental; Fluorescent Antibody Technique; Glucagon; Glucagon-Secreting Cells; Immunohistochemistry; Insulin; Islets of Langerhans; Mice; Microscopy, Confocal; Oxidative Stress; Streptozocin | 2007 |
Young NOD mice show increased diabetes sensitivity to low doses of streptozotocin.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Dose-Response Relationship, Drug; Female; Glucagon; Histocytochemistry; Immunohistochemistry; Incidence; Insulin; Islets of Langerhans; Mice; Mice, Inbred NOD; Mice, Inbred Strains; Streptozocin; Time Factors | 2006 |
Vitamin E decreases the hyperglucagonemia of diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Gene Expression Regulation; Glucagon; Insulin; Male; Rats; Rats, Wistar; Vitamin E | 2006 |
Mist1-null mice are resistant to streptozotocin-induced beta cell damage.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Blood Glucose; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Female; Fluorescent Antibody Technique; Glucagon; Glucose Transporter Type 2; Insulin; Insulin-Secreting Cells; Isopropyl Thiogalactoside; Mice; Mice, Inbred C57BL; Mice, Knockout; Streptozocin | 2007 |
Dual-acting peptide with prolonged glucagon-like peptide-1 receptor agonist and glucagon receptor antagonist activity for the treatment of type 2 diabetes.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Female; Gastrointestinal Motility; Glucagon; Glucagon-Like Peptide-1 Receptor; Glucose Tolerance Test; Insulin; Intercellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Mutant Strains; Obesity; Peptide Fragments; Peptides; Polyethylene Glycols; Rats; Rats, Wistar; Receptors, Glucagon | 2007 |
Pharmacodynamics and stability of subcutaneously infused glucagon in a type 1 diabetic Swine model in vivo.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucagon; Humans; Hypoglycemic Agents; Infusions, Parenteral; Insulin; Insulin-Secreting Cells; Male; Swine | 2007 |
Effects of activin A on pancreatic ductal cells in streptozotocin-induced diabetic rats.
Topics: Activins; Amylases; Animals; Cells, Cultured; Diabetes Mellitus, Experimental; Glucagon; Glucose; Insulin; Insulin Secretion; Male; Pancreas Transplantation; Pancreatic Ducts; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; Subrenal Capsule Assay | 2007 |
Reversal of streptozotocin-induced diabetes in rats by gene therapy with betacellulin and pancreatic duodenal homeobox-1.
Topics: Amylases; Animals; Betacellulin; Biomarkers; Blood Glucose; C-Peptide; Diabetes Mellitus, Experimental; Gene Expression; Genetic Therapy; Glucagon; Homeodomain Proteins; Insulin; Intercellular Signaling Peptides and Proteins; Male; Microbubbles; Pancreas, Exocrine; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Trans-Activators; Ultrasonics | 2007 |
Differentiation of transplanted microencapsulated fetal pancreatic cells.
Topics: Alginates; Animals; Blood Glucose; Capsules; Cell Aggregation; Cell Differentiation; Cell Survival; Diabetes Mellitus, Experimental; Fetal Tissue Transplantation; Fluorescent Antibody Technique; Glucagon; Glucose; Glucuronic Acid; Hexuronic Acids; Insulin; Insulin Secretion; Insulin-Secreting Cells; Islets of Langerhans; Male; Mice; Mice, SCID; Pancreas; Staining and Labeling; Time Factors | 2007 |
Effects of subchronic treatment with the long-acting glucose-dependent insulinotropic polypeptide receptor agonist, N-AcGIP, on glucose homeostasis in streptozotocin-induced diabetes.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Eating; Gastric Inhibitory Polypeptide; Glucagon; Glucose Tolerance Test; Glycated Hemoglobin; Homeostasis; Insulin; Islets of Langerhans; Male; Mice; Somatostatin | 2007 |
Afferent signalling through the common hepatic branch of the vagus inhibits voluntary lard intake and modifies plasma metabolite levels in rats.
Topics: Adipose Tissue, White; Adrenal Glands; Afferent Pathways; Animals; Biomarkers; Blood Glucose; Body Weight; Capsaicin; Corticosterone; Diabetes Mellitus, Experimental; Dietary Fats; Feeding Behavior; Food Preferences; Glucagon; Glycogen; Hypoglycemic Agents; Insulin; Leptin; Lipids; Liver; Male; Organ Size; Rats; Rats, Sprague-Dawley; Spleen; Thymus Gland; Time Factors; Vagus Nerve | 2007 |
Metabolic aspects of pig-to-monkey (Macaca fascicularis) islet transplantation: implications for translation into clinical practice.
Topics: Animals; Blood Glucose; C-Peptide; Diabetes Mellitus, Experimental; Female; Glucagon; Insulin; Islets of Langerhans Transplantation; Macaca fascicularis; Male; Metabolism; Sus scrofa; Time Factors; Transplantation, Heterologous; Treatment Outcome | 2008 |
The gastroduodenal branch of the common hepatic vagus regulates voluntary lard intake, fat deposition, and plasma metabolites in streptozotocin-diabetic rats.
Topics: Animals; Blood Glucose; Body Fat Distribution; Corticosterone; Diabetes Mellitus, Experimental; Dietary Fats; Eating; Fatty Acids; Gastric Inhibitory Polypeptide; Glucagon; Glycogen; Hypoglycemic Agents; Insulin; Liver; Male; Rats; Rats, Sprague-Dawley; Vagotomy; Vagus Nerve; Weight Loss | 2008 |
Pancreatic islet immunoreactivity to the Reg protein INGAP.
Topics: Animals; Antigen-Antibody Reactions; Antigens, Neoplasm; Biomarkers, Tumor; Cell Line; Cross Reactions; Diabetes Mellitus, Experimental; Glucagon; Glucagon-Secreting Cells; Haplorhini; Humans; Immunohistochemistry; Insulin; Intracellular Space; Islets of Langerhans; Lectins, C-Type; Male; Mice; Pancreatitis-Associated Proteins; Protein Transport; Proteins; Rats; Recombinant Proteins; Species Specificity | 2008 |
Effect of tetrapeptide pancragene on functional morphology of the pancreas in rats with experimental diabetes mellitus.
Topics: Animals; Apoptosis; Cell Proliferation; Diabetes Mellitus, Experimental; Glucagon; Insulin; Oligopeptides; Pancreas; Proliferating Cell Nuclear Antigen; Rats; Tumor Suppressor Protein p53 | 2007 |
Daily administration of the GIP-R antagonist (Pro3)GIP in streptozotocin-induced diabetes suggests that insulin-dependent mechanisms are critical to anti-obesity-diabetes actions of (Pro3)GIP.
Topics: Animals; Anti-Obesity Agents; Blood Glucose; Diabetes Mellitus, Experimental; Gastric Inhibitory Polypeptide; Glucagon; Glycated Hemoglobin; Insulin; Insulin-Secreting Cells; Male; Mice; Mice, Inbred Strains; Models, Animal; Random Allocation; Receptors, Gastrointestinal Hormone; Somatostatin | 2008 |
Excessive islet NO generation in type 2 diabetic GK rats coincides with abnormal hormone secretion and is counteracted by GLP-1.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Male; Microscopy, Confocal; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; Rats, Wistar | 2008 |
Regulation of tyrosine alpha-ketoglutarate transaminase in rat liver. VI. Induction by pancreatic hormones.
Topics: Adrenalectomy; Animals; Carbon Isotopes; Dactinomycin; Depression, Chemical; Diabetes Mellitus, Experimental; Enzyme Induction; Glucagon; Hydrocortisone; Insulin; Liver; Male; Precipitin Tests; Rats; Stimulation, Chemical; Transaminases | 1967 |
Streptozotocin diabetes in the monkey: plasma levels of glucose, insulin, glucagon, and somatostatin, with corresponding morphometric analysis of islet endocrine cells.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Female; Glucagon; Haplorhini; Insulin; Insulin Secretion; Islets of Langerhans; Somatostatin; Streptozocin | 1980 |
Increase of pancreatic somatostatin concentration in early phases of streptozotocin diabetes in rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucagon; Glucose; Insulin; Male; Pancreas; Rats; Somatostatin | 1980 |
Regulation of hepatic fatty acid-synthesizing enzymes of diabetic animals by thyroid-hormone.
Topics: Acetyl-CoA Carboxylase; Animals; Cycloheximide; Dactinomycin; Diabetes Mellitus, Experimental; Fatty Acid Synthases; Glucagon; Growth Hormone; Insulin; Kinetics; Ligases; Liver; Male; Rats; Thyroxine; Triiodothyronine | 1980 |
Immunocytochemical study of the endocrine pancreas in the rat during normal pregnancy and during experimental diabetic pregnancy.
Topics: Animals; Diabetes Mellitus, Experimental; Female; Glucagon; Insulin; Islets of Langerhans; Pancreatic Polypeptide; Pregnancy; Pregnancy in Diabetics; Rats; Somatostatin | 1980 |
Diabetes in pregnancy: effects on the foetal and newborn rat with particular regard to body weight, serum insulin concentration and pancreatic contents of insulin, glucagon and somatostatin.
Topics: Animals; Animals, Newborn; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Female; Glucagon; Insulin; Litter Size; Maternal-Fetal Exchange; Organ Size; Pancreas; Pregnancy; Pregnancy in Diabetics; Radioimmunoassay; Rats; Somatostatin | 1980 |
Somatostatin release from the isolated, perfused diabetic rat pancreas: inverse relationship between pancreatic somatostatin and insulin.
Topics: Animals; Arginine; Blood Glucose; Diabetes Mellitus, Experimental; Glucagon; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Male; Pancreas; Perfusion; Rats; Somatostatin | 1980 |
Reversal of the enhanced somatostatin release from the isolated, perfused diabetic rat pancreas after the amelioration of diabetes by whole pancreas transplantation.
Topics: Animals; Arginine; Blood Glucose; Diabetes Mellitus, Experimental; Glucagon; Insulin; Kinetics; Male; Pancreas; Pancreas Transplantation; Rats; Somatostatin; Transplantation, Homologous | 1980 |
Elevated portal and peripheral blood concentration of immunoreactive somatostatin in spontaneously diabetic (BBL) Wistar rats: suppression with insulin.
Topics: Animals; Body Weight; Diabetes Mellitus, Experimental; Fluorescent Antibody Technique; Gastric Mucosa; Glucagon; Glucose; Insulin; Intestinal Mucosa; Islets of Langerhans; Rats; Somatostatin | 1980 |
Increased somatostatin secretion from pancreatic islets of streptozotocin-diabetic rats in response to glucose.
Topics: Animals; Diabetes Mellitus, Experimental; Glucagon; Glucose; Islets of Langerhans; Rats; Somatostatin; Theophylline | 1980 |
Concentration and secretion of gastric somatostatin in streptozotocin-diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Gastric Mucosa; Glucagon; Insulin; Male; Rats; Somatostatin; Streptozocin | 1981 |
Acute effects of alloxan- and streptozotocin-induced insulin deficiency on somatostatin and glucagon secretion by the perfused isolated rat pancreatico-duodenal preparation.
Topics: Alloxan; Animals; Arginine; Diabetes Mellitus, Experimental; Duodenum; Glucagon; Glucose; Insulin; Male; Pancreas; Rats; Somatostatin; Streptozocin; Theophylline | 1981 |
Islet secretion in a new experimental model for non-insulin-dependent diabetes.
Topics: Animals; Arginine; Diabetes Mellitus, Experimental; Disease Models, Animal; Female; Glucagon; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Isoproterenol; Male; Pregnancy; Rats; Somatostatin; Theophylline; Tolbutamide | 1981 |
Chromatographic pattern of extrapancreatic glucagon and glucagon-like immunoreactivity before and during stimulation by epinephrine and participation of glucagon in epinephrine-induced hepatic glucose overproduction.
Topics: Animals; Chromatography; Diabetes Mellitus, Experimental; Dogs; Epinephrine; Glucagon; Glucose; Liver; Pancreatectomy; Somatostatin | 1981 |
The effect of glucose and tolbutamide on immunoreactive somatostatin release from perifused pancreatic islets of normal and streptozotocin diabetic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucagon; Glucose; Insulin; Islets of Langerhans; Male; Perfusion; Radioimmunoassay; Rats; Somatostatin; Tolbutamide | 1980 |
Reversal of increased gastric somatostatin in streptozotocin-diabetic rats by whole pancreas transplantation.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Gastric Mucosa; Glucagon; Insulin; Kinetics; Male; Pancreas Transplantation; Perfusion; Rats; Rats, Inbred Lew; Somatostatin; Stomach | 1981 |
Limited B cell regeneration in a B cell deficient rat model: studies with dexamethasone.
Topics: Animals; Animals, Newborn; Dexamethasone; Diabetes Mellitus, Experimental; Glucagon; Insulin; Islets of Langerhans; Male; Rats; Rats, Inbred Strains; Regeneration; Somatostatin; Streptozocin | 1981 |
Origin of peripheral venous hypersomatostatinemia in alloxan-diabetic dogs.
Topics: Animals; Diabetes Mellitus, Experimental; Dogs; Eating; Glucagon; Kinetics; Somatostatin; Veins | 1981 |
Characterisation of the abnormal pancreatic D and A cell function in streptozotocin diabetic dogs: studies with D-glyceraldehyde, dihydroxyacetone, D-mannoheptulose, D-glucose, and L-arginine.
Topics: Animals; Arginine; Diabetes Mellitus, Experimental; Dihydroxyacetone; Dogs; Glucagon; Glucose; Glyceraldehyde; Heptoses; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Mannoheptulose; Somatostatin; Trioses | 1981 |
Dynamic time-course studies of the spontaneously diabetic BB Wistar rat. II. Insulin-, glucagon-, and somatostatin-reactive cells in the pancreas.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucagon; Histocytochemistry; Insulin; Islets of Langerhans; Organ Size; Rats; Rats, Inbred Strains; Somatostatin | 1981 |
Changes in somatostatin release from perfused pancreas of streptozotocin-induced diabetic rats.
Topics: Animals; Arginine; Body Weight; Diabetes Mellitus, Experimental; Glucagon; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Perfusion; Rats; Rats, Inbred Strains; Somatostatin | 1981 |
Regulation of the levels of phosphoenolpyruvate carboxykinase (GTP) mRNA in rat liver by insulin and glucagon.
Topics: Animals; Bucladesine; Diabetes Mellitus, Experimental; Glucagon; Glucose; In Vitro Techniques; Insulin; Liver; Male; Phosphoenolpyruvate Carboxykinase (GTP); Rats; RNA, Messenger; Somatostatin | 1980 |
Somatostatin secretion in diabetic rabbits.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucagon; Insulin; Islets of Langerhans; Rabbits; Somatostatin | 1982 |
State of metabolic control determines role of epinephrine-glucagon interaction in glucoregulation in diabetes.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Drug Synergism; Epinephrine; Fatty Acids, Nonesterified; Glucagon; Insulin; Kinetics; Metabolic Clearance Rate; Somatostatin | 1982 |
Effect of high glucagon infusions on blood glucose, plasma insulin and beta-OH-butyrate concentrations in streptozotocin-diabetic and normal Osborne Mendel rats.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Female; Glucagon; Hydroxybutyrates; Infusions, Parenteral; Insulin; Rats; Rats, Inbred Strains | 1982 |
Pancreatic somatostatin contents in spontaneously diabetic KK and non-obese diabetic (NOD) mice.
Topics: Animals; Diabetes Mellitus, Experimental; Glucagon; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Obese; Pancreas; Somatostatin | 1982 |
Glucoregulatory mechanisms following hypophysectomy in diabetic dogs with residual insulin secretion.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Glucagon; Hypophysectomy; Insulin; Insulin Secretion; Kinetics; Liver; Metabolic Clearance Rate; Somatostatin | 1983 |
Stimulatory effect of beta-hydroxybutyrate on the release of somatostatin from the isolated pancreas of normal and streptozotocin-diabetic dogs.
Topics: 3-Hydroxybutyric Acid; Animals; Bicarbonates; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Glucagon; Hydroxybutyrates; In Vitro Techniques; Insulin; Islets of Langerhans; Sodium Bicarbonate; Sodium Chloride; Somatostatin | 1982 |
Loss of a priming effect of glucose on A and D cell secretion in perfused pancreases from alloxan-diabetic rats: role of insulin and alloxan.
Topics: Alloxan; Animals; Arginine; Diabetes Mellitus, Experimental; Glucagon; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Pancreatic Hormones; Perfusion; Rats; Rats, Inbred Strains; Somatostatin | 1983 |
Opposing actions of glucagon and insulin on splanchnic d cell function.
Topics: Animals; Diabetes Mellitus, Experimental; Dogs; Gastric Mucosa; Glucagon; Infusions, Parenteral; Insulin; Islets of Langerhans; Radioimmunoassay; Somatostatin | 1983 |
Effect of spontaneous diabetes on hormone release in BB/Phi rats: comparison between the isolated perfused pancreas/stomach/duodenum/spleen and the isolated perfused pancreas.
Topics: Animals; Diabetes Mellitus, Experimental; Duodenum; Female; Gastric Mucosa; Glucagon; Hormones; Insulin; Insulin Secretion; Islets of Langerhans; Male; Organ Specificity; Pancreas; Perfusion; Rats; Rats, Mutant Strains; Somatostatin; Spleen | 1983 |
The long-term allografted rat islet. A histologic and immunohistologic study.
Topics: Animals; Diabetes Mellitus, Experimental; Female; Glucagon; Glucose Tolerance Test; Graft Rejection; Graft Survival; Histocytochemistry; Insulin; Islets of Langerhans; Islets of Langerhans Transplantation; Kidney Transplantation; Rats; Rats, Inbred Lew; Somatostatin; Transplantation, Autologous; Transplantation, Homologous | 1983 |
Effect of tolbutamide on insulin, glucagon, and somatostatin release from the diabetic rat pancreas with special reference to glucose concentration.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucagon; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Male; Perfusion; Rats; Rats, Inbred Strains; Somatostatin; Tolbutamide | 1983 |
Alterations in somatostatin and other islet cell functions in the spontaneously diabetic BB Wistar rat: biochemical and morphological characterization.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Fluorescent Antibody Technique; Glucagon; Insulin; Islets of Langerhans; Pancreas; Perfusion; Rats; Rats, Inbred Strains; Somatostatin | 1983 |
Spontaneous diabetes mellitus syndrome in the rat. III. Pancreatic alterations in aglycosuric and untreated diabetic BB Wistar-derived rats.
Topics: Age Factors; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Female; Glucagon; Glycosuria; Insulin; Male; Microscopy, Electron; Pancreas; Rats; Rats, Inbred Strains; Somatostatin | 1983 |
The effect of hyperglycaemia on the rates of appearance and metabolic clearance of glucose in sheep (Ovis aries).
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Female; Glucagon; Insulin; Metabolic Clearance Rate; Sheep | 1983 |
Normalization of hepatic lysosomal autophagy in streptozotocin diabetic rats after pancreatic transplantation.
Topics: Animals; Autophagy; Diabetes Mellitus, Experimental; Glucagon; Liver; Lysosomes; Male; Microscopy, Electron; Pancreas Transplantation; Rats; Time Factors; Vacuoles | 1983 |
Glucagon suppression improves glucoregulation in moderate but not chronic severe diabetes.
Topics: Alloxan; Animals; Diabetes Mellitus, Experimental; Dogs; Glucagon; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Pancreatectomy; Somatostatin | 1983 |
A super active cyclic hexapeptide analog of somatostatin.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Glucagon; Growth Hormone; Hyperglycemia; In Vitro Techniques; Insulin; Insulin Secretion; Mice; Oligopeptides; Peptides, Cyclic; Rats; Somatostatin; Structure-Activity Relationship | 1984 |
Somatostatin, glucagon, and insulin secretion from perfused pancreas of BB rats.
Topics: Animals; Arginine; Diabetes Mellitus, Experimental; Glucagon; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Male; Perfusion; Rats; Rats, Mutant Strains; Somatostatin; Theophylline | 1984 |
Effects of (-)-(R)-1-(p-hydroxyphenyl)-2-[3,4-dimethoxyphenethyl)amino]ethanol (TA-064), a new cardiotonic agent, on circulating parameters of carbohydrate and lipid metabolism in the rat.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Blood Glucose; Cardiotonic Agents; Diabetes Mellitus, Experimental; Ethanolamines; Fatty Acids, Nonesterified; Glucagon; Glycerol; Insulin; Isoproterenol; Lactates; Lactic Acid; Lipid Metabolism; Male; Rats; Rats, Inbred Strains | 1984 |
Insulin, glucagon, and somatostatin release from the prediabetic Chinese hamster.
Topics: Aging; Animals; Arginine; Cricetinae; Cricetulus; Diabetes Mellitus, Experimental; Glucagon; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Male; Mutation; Prediabetic State; Somatostatin | 1984 |
Effect of a zinc phosphate suspension of a long-acting somatostatin analog on postprandial plasma glucose, triglyceride and glucagon concentrations in alloxan diabetic dogs.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Fats; Feces; Glucagon; Phosphates; Somatostatin; Suspensions; Triglycerides; Xylose; Zinc; Zinc Compounds | 1984 |
Hormonal regulation of liver pyruvate kinase concentration and activity.
Topics: Animals; Diabetes Mellitus, Experimental; gamma-Globulins; Glucagon; Immunoassay; Kinetics; Liver; Pyruvate Kinase; Rabbits; Radioimmunoassay; Thyroxine; Triamcinolone | 1980 |
Alterations in glomerular RNA in diabetic rats: roles of glucagon and insulin.
Topics: Adenine; Animals; Biotransformation; Diabetes Mellitus, Experimental; Glucagon; Glucose; Insulin; Kidney Glomerulus; Male; Orotic Acid; Rats; RNA; Streptozocin | 1981 |
Modulation by IBMX, fasting and experimental diabetes of glibenclamide-induced islet hormone release from the perfused rat pancreas.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Fasting; Glucagon; Glyburide; Insulin; Insulin Secretion; Male; Pancreas; Pancreatic Hormones; Rats; Rats, Inbred Strains; Somatostatin; Theophylline | 1983 |
Induction and decay of amino acid transport in the liver. Turnover of transport activity in isolated hepatocytes after stimulation by diabetes or glucagon.
Topics: Amino Acids; Animals; Biological Transport; Cell Membrane; Cycloheximide; Dactinomycin; Diabetes Mellitus, Experimental; Glucagon; In Vitro Techniques; Kinetics; Liver; Male; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; RNA, Messenger | 1984 |
Intestinal motility responses to insulin and glucagon in streptozotocin diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Gastrointestinal Motility; Glucagon; Insulin; Insulin Coma; Male; Rats; Rats, Inbred Strains; Streptozocin | 1982 |
A longitudinal and comparative study of some structural and hormonal alterations in the endocrine pancreas of spontaneously diabetic and streptozotocin-induced diabetic mice.
Topics: Aging; Animals; Antigens; Diabetes Mellitus, Experimental; Glucagon; Insulin; Insulin Antagonists; Islets of Langerhans; Longitudinal Studies; Male; Mice; Mice, Inbred C57BL; Streptozocin | 1983 |
Selective alteration of secretin-stimulated cardiac adenylate cyclase activity in streptozotocin-diabetic rats.
Topics: Adenylyl Cyclases; Animals; Diabetes Mellitus, Experimental; Glucagon; Guanosine Triphosphate; Isoproterenol; Male; Myocardium; Rats; Rats, Inbred Strains; Secretin; Sodium Fluoride; Streptozocin | 1983 |
Glucagon secretion by dispersed alpha cell enriched islets from streptozotocin treated hamsters in perifusion.
Topics: Animals; Blood Glucose; Cricetinae; Diabetes Mellitus, Experimental; Female; Glucagon; In Vitro Techniques; Insulin; Islets of Langerhans; Mesocricetus; Streptozocin | 1984 |
Regulation of hepatic triiodothyronine production in the streptozotocin-induced diabetic rat.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Glucagon; Insulin; Liver; Male; Organ Size; Rats; Rats, Inbred Strains; Streptozocin; Thyroxine; Triiodothyronine | 1984 |
Regulation of rat liver plasma membrane and intracellular insulin binding sites during diabetes, liver regeneration, and hyperinsulinism: radiolabeled hormone binding and electron microscopic autoradiograph studies.
Topics: Animals; Autoradiography; Cell Membrane; Cell Nucleus; Cytosol; Diabetes Mellitus, Experimental; Female; Glucagon; Hyperinsulinism; Insulin; Liver; Liver Regeneration; Microscopy, Electron; Rats; Receptor, Insulin; Receptors, Cell Surface | 1980 |
A decreased response of cyclic adenosine monophosphate concentrations to glucagon in liver slices from streptozotocin-induced diabetic rats.
Topics: Animals; Blood Glucose; Cell Membrane; Cyclic AMP; Diabetes Mellitus, Experimental; Glucagon; Glucose; Insulin; Liver; Rats | 1980 |
Cyclic nucleotides in diabetes mellitus and obesity.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adipose Tissue; Animals; Cyclic AMP; Cyclic GMP; Diabetes Mellitus; Diabetes Mellitus, Experimental; Epinephrine; Glucagon; Humans; Insulin; Isoproterenol; Liver; Male; Mice; Mice, Obese; Obesity; Rats | 1980 |
High-fiber diet in the control of diabetes in rats.
Topics: Animals; Blood Glucose; Body Weight; Cellulose; Cholesterol; Diabetes Mellitus, Experimental; Dietary Fiber; Glucagon; Male; Rats; Triglycerides | 1980 |
Effect of islet-activating protein (IAP), purified from the culture medium of Bordetella pertussis, on the secretion of immunoreactive insulin and glucagon in normal, alloxan-treated, and depancreatized dogs.
Topics: Alloxan; Animals; Arginine; Bacterial Proteins; Blood Glucose; Bordetella pertussis; Diabetes Mellitus, Experimental; Dogs; Dose-Response Relationship, Drug; Glucagon; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Pancreatectomy; Pertussis Toxin; Virulence Factors, Bordetella | 1981 |
The effect of hyperthermic stress on blood glucagon levels in normal and diabetic rats.
Topics: Adipose Tissue; Animals; Cyclic AMP; Diabetes Mellitus, Experimental; Fever; Glucagon; Male; Rats | 1981 |
Control of fatty acid synthetase mRNA levels in rat liver by insulin, glucagon, and dibutyl cyclic AMP.
Topics: Animals; Bucladesine; Diabetes Mellitus, Experimental; Fatty Acid Synthases; Glucagon; Insulin; Liver; Male; Polyribosomes; Protein Biosynthesis; Rabbits; Rats; Reticulocytes; RNA, Messenger; Transcription, Genetic | 1981 |
Alterations in hepatic nuclear binding of triiodothyronine in experimental diabetes mellitus in rats.
Topics: Animals; Blood Glucose; Cell Nucleus; Diabetes Mellitus, Experimental; Glucagon; Insulin; Liver; Male; Rats; Receptors, Cell Surface; Triiodothyronine | 1982 |
Hyperglycemia of diabetic rats decreased by a glucagon receptor antagonist.
Topics: Animals; Diabetes Mellitus, Experimental; Glucagon; Hyperglycemia; Male; Rats; Receptors, Cell Surface; Receptors, Glucagon; Structure-Activity Relationship | 1982 |
Increased dose-response relationship of liver plasma membrane adenylate cyclase to glucagon stimulation in diabetic rats. A possible role of the guanyl nucleotide-binding regulatory protein.
Topics: Adenylyl Cyclases; Animals; Cell Membrane; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Glucagon; GTP-Binding Proteins; Guanosine Triphosphate; Insulin; Liver; Male; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Sodium Fluoride; Streptozocin | 1982 |
Short-term effect of glucagon on gluconeogenesis and pyruvate kinase in rabbit hepatocytes.
Topics: Animals; Bucladesine; Diabetes Mellitus, Experimental; Glucagon; Gluconeogenesis; Lactates; Liver; Phosphoenolpyruvate; Pyruvate Kinase; Rabbits; Time Factors; Urea | 1982 |
Maternal diabetes does not alter postnatal development of the hepatic glucagon receptor-adenylate cyclase system in the rat.
Topics: Adenylyl Cyclases; Age Factors; Animals; Animals, Newborn; Cell Membrane; Cyclic AMP; Diabetes Mellitus, Experimental; Female; Glucagon; Liver; Maternal-Fetal Exchange; Pregnancy; Rats; Receptors, Cell Surface; Streptozocin | 1983 |
Encephalomyocarditis virus induced diabetes mellitus in mice: long-term changes in the structure and function of islets of Langerhans.
Topics: Animals; Diabetes Mellitus, Experimental; Encephalomyocarditis virus; Enterovirus Infections; Glucagon; Glucose Tolerance Test; Immunoenzyme Techniques; Insulin; Islets of Langerhans; Male; Mice; Time Factors | 1983 |
Role of glucagon in increase of hepatic glycerate kinase of adult and neonatal rats.
Topics: Age Factors; Animals; Bucladesine; Cytosol; Diabetes Mellitus, Experimental; Glucagon; Gluconeogenesis; Liver; Mitochondria; Phosphotransferases; Phosphotransferases (Alcohol Group Acceptor); Rats; Triamcinolone | 1983 |
Effect of brown rice and soybean dietary fiber on the control of glucose and lipid metabolism in diabetic rats.
Topics: Animals; Cholesterol; Diabetes Mellitus, Experimental; Dietary Fiber; Glucagon; Glucose; Glucose Tolerance Test; Glycine max; Insulin; Lipids; Male; Oryza; Rats; Triglycerides | 1983 |
Decreased glucagon-stimulated cyclic AMP production by isolated liver cells of rats with type 2 diabetes.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Animals; Cyclic AMP; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucagon; In Vitro Techniques; Insulin; Liver; Rats; Rats, Inbred Strains | 1983 |
Phosphorylase activation hypersensitivity in hearts of diabetic rats.
Topics: Animals; Calcium; Cyclic AMP; Diabetes Mellitus, Experimental; Enzyme Activation; Epinephrine; Glucagon; Heart; Male; Myocardium; Perfusion; Phosphorylase Kinase; Phosphorylase Phosphatase; Phosphorylases; Protein Kinases; Rats; Rats, Inbred Strains | 1984 |
[Forskolin, cyclic AMP and hormone regulation].
Topics: Adrenal Glands; Animals; Cell Membrane Permeability; Colforsin; Corticosterone; Cyclic AMP; Deoxyglucose; Diabetes Mellitus, Experimental; Diterpenes; Glucagon; In Vitro Techniques; Liver; Phosphofructokinase-1; Phosphotransferases; Rats | 1983 |
Glucagon-stimulable adenylyl cyclase in rat liver. The impact of streptozotocin-induced diabetes mellitus.
Topics: Adenylyl Cyclases; Animals; Cell Membrane; Diabetes Mellitus, Experimental; Enzyme Activation; Female; Glucagon; Insulin; Kinetics; Liver; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Cell Surface; Receptors, Glucagon | 1984 |
Elevated proinsulin biosynthesis in vitro from a rat model of non-insulin-dependent diabetes mellitus.
Topics: Amino Acids; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Glucagon; Glucose Tolerance Test; Insulin; Insulin Secretion; Islets of Langerhans; Male; Proinsulin; Proteins; Rats; Rats, Inbred Strains | 1983 |
Rate of insulin infusion with a minipump required to maintain a normoglycemia in diabetic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucagon; Insulin; Insulin Infusion Systems; Kinetics; Male; Rats; Rats, Inbred Strains | 1983 |
Glucose- and arginine-induced insulin and glucagon responses from the isolated perfused pancreas of the BB-Wistar diabetic rat. Evidence for selective impairment of glucose regulation.
Topics: Animals; Arginine; Blood Glucose; Diabetes Mellitus, Experimental; Glucagon; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Male; Pancreas; Perfusion; Rats; Rats, Inbred Strains | 1983 |
Clinical forms and natural history of the diabetic syndrome and insulin and glucagon secretion in the BB rat.
Topics: Animals; Arginine; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Female; Glucagon; Insulin; Insulin Secretion; Male; Rats; Rats, Inbred Strains; Stress, Physiological; Tolbutamide | 1983 |
Hyperglycemic action of zinc in rats.
Topics: Adrenalectomy; Animals; Blood Glucose; Dexamethasone; Diabetes Mellitus, Experimental; Glucagon; Insulin; Liver Glycogen; Male; Phenoxybenzamine; Propranolol; Rats; Rats, Inbred Strains; Zinc | 1983 |
Plasma membrane transport of 2-ketoisocaproate by rat hepatocytes in primary culture.
Topics: Animals; Biological Transport; Cell Membrane; Cells, Cultured; Dexamethasone; Diabetes Mellitus, Experimental; Glucagon; Insulin; Keto Acids; Kinetics; Liver; Male; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains; Sodium | 1983 |
Effect of prolonged insulin treatment on blunted plasma catecholamine and glucagon increase during insulin hypoglycemia in streptozotocin diabetic rats.
Topics: Animals; Catecholamines; Diabetes Mellitus, Experimental; Glucagon; Hypoglycemia; Insulin; Insulin Infusion Systems; Male; Rats; Rats, Inbred Strains | 1983 |
Glucagon does not modulate the alterations in T3 metabolism consequent to dietary manipulation and diabetes.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dietary Carbohydrates; Fasting; Glucagon; Insulin; Iodide Peroxidase; Liver; Male; Rats; Rats, Inbred Strains; Triiodothyronine | 1983 |
Ciglitazone, a new hypoglycemic agent. I. Studies in ob/ob and db/db mice, diabetic Chinese hamsters, and normal and streptozotocin-diabetic rats.
Topics: Animals; Blood Glucose; Cricetinae; Cricetulus; Diabetes Mellitus, Experimental; Fatty Acids, Nonesterified; Glucagon; Hypoglycemic Agents; Insulin; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Rats; Thiazoles; Thiazolidinediones; Triglycerides | 1983 |
Glucose metabolism studied isotopically in diabetic dogs: effect of restoration of peripheral normoinsulinaemia by the artificial B cell.
Topics: Animals; Blood Glucose; Carbon Radioisotopes; Diabetes Mellitus, Experimental; Dogs; Glucagon; Glucose; Insulin; Insulin Infusion Systems; Ketone Bodies; Kinetics; Lactates; Lactic Acid; Tritium | 1983 |
[Experimental study on diabetes and pregnancy: with special reference to the effects of insulin treatment on fetuses of diabetic dams].
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Female; Fetus; Glucagon; Insulin; Male; Maternal-Fetal Exchange; Pancreas; Pregnancy; Pregnancy in Diabetics; Rats; Rats, Inbred Strains | 1983 |
Plasma pancreatic glucagon response to blood glucose in experimental pancreatolithiasis in dogs.
Topics: Animals; Blood Glucose; Chronic Disease; Diabetes Mellitus, Experimental; Dogs; Glucagon; Glucose; Insulin; Ligation; Pancreatic Ducts; Pancreatitis | 1983 |
Plasma responses of pancreatic polypeptide, glucagon and insulin in normal and alloxan diabetic dogs, and their regional levels in the pancreas.
Topics: Animals; Blood Glucose; Cattle; Diabetes Mellitus, Experimental; Dogs; Food; Glucagon; Insulin; Male; Meat; Pancreas; Pancreatic Polypeptide | 1984 |
Glucagon secretory responses to insulin-induced hypoglycemia and arginine in streptozotocin-induced diabetic dogs.
Topics: Animals; Arginine; Cell Communication; Diabetes Mellitus, Experimental; Dogs; Female; Glucagon; Hypoglycemia; Insulin; Insulin Secretion; Islets of Langerhans; Male | 1983 |
[Gastric secretion after major resection of the pancreas, with special reference to gut hormones and gastric acid secretion in Sandmeyer's diabetes].
Topics: Animals; Diabetes Mellitus, Experimental; Dogs; Gastric Acid; Gastrins; Glucagon; Insulin; Pancreatectomy; Postoperative Period; Secretin | 1983 |
Development of early lesions of microangiopathy in chronically diabetic monkeys.
Topics: Animals; Basement Membrane; Blood Glucose; Capillaries; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Female; Glomerular Mesangium; Glucagon; Insulin; Ketone Bodies; Kidney Glomerulus; Lipids; Macaca; Male; Microscopy, Electron; Muscles; Proteinuria | 1984 |
The effects of exercise and food restriction on obesity and diabetes in young ob/ob mice.
Topics: Adipose Tissue; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Energy Intake; Glucagon; Insulin; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity; Physical Exertion | 1984 |
[The pathogenesis of diabetes produced by subtotal pancreatectomy, with special reference to the cell kinetics of the islet cells].
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucagon; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Male; Pancreatectomy; Rats; Rats, Inbred Strains; Regeneration | 1984 |
Time course of serum glucoregulatory variables and lipids following neonatal thymectomy of diabetes-prone and control BB Wistar rats fed a defined diet.
Topics: Animals; Animals, Newborn; Blood Glucose; Cholesterol; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Disease Models, Animal; Female; Food, Formulated; Glucagon; Insulin; Male; Rats; Rats, Inbred Strains; Thymectomy | 1984 |
[The effect of oral synthetic protease inhibitor (FOY 305) on endocrine pancreas and carbohydrate and lipid metabolism in normal and streptozotocin-induced diabetic rats].
Topics: Animals; Blood Glucose; Body Weight; Carbohydrate Metabolism; Diabetes Mellitus, Experimental; Esters; Gabexate; Glucagon; Guanidines; Insulin; Islets of Langerhans; Lipid Metabolism; Liver; Organ Size; Protease Inhibitors; Rats; Rats, Inbred Strains | 1984 |
Role of sympathetic nervous system in glucagon response to insulin hypoglycemia in normal and diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Epinephrine; Glucagon; Hypoglycemia; Insulin; Male; Phentolamine; Propranolol; Rats; Rats, Inbred Strains; Sympathetic Nervous System; Yohimbine | 1984 |
Role of parasympathetic nervous system in glucagon response to insulin-induced hypoglycemia in normal and diabetic rats.
Topics: Animals; Atropine; Blood Glucose; Carbachol; Diabetes Mellitus, Experimental; Epinephrine; Glucagon; Hypoglycemia; Insulin; Male; Parasympathetic Nervous System; Rats; Rats, Inbred Strains | 1984 |
Insulin and glucagon in spontaneously diabetic non-obese mice.
Topics: Animals; Body Weight; Diabetes Mellitus, Experimental; Female; Glucagon; Insulin; Islets of Langerhans; Mice; Mice, Inbred ICR; Mice, Mutant Strains; Organ Size; Pancreas | 1984 |
Plasma responses and pancreatic content of pancreatic polypeptide, glucagon and insulin in alloxan diabetic and normal dogs and their immunohistological studies.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Food; Glucagon; Immunoenzyme Techniques; Insulin; Male; Pancreas; Pancreatic Polypeptide; Tissue Distribution | 1984 |
Regulation of carbohydrate metabolism by 2,5-anhydro-D-mannitol.
Topics: Animals; Carbohydrate Metabolism; Diabetes Mellitus, Experimental; Fructosediphosphates; Glucagon; Gluconeogenesis; Glycolysis; In Vitro Techniques; Kinetics; Lactates; Lactic Acid; Liver; Mannitol; Rats | 1983 |
Chemically induced (streptozotocin-alloxan) diabetes mellitus in the dog. Biochemical and ultrastructural studies.
Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Glucagon; Hydrocortisone; Insulin; Islets of Langerhans; Pancreatic Diseases; Streptozocin | 1980 |
Insulin, glucagon, and somatostatin secretion from isolated perfused rat and chicken pancreas-duodenum.
Topics: Animals; Arginine; Chickens; Diabetes Mellitus, Experimental; Duodenum; Glucagon; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Male; Radioimmunoassay; Rats; Somatostatin; Streptozocin | 1980 |
Effect of streptozotocin-induced diabetes on renal ornithine decarboxylase activity.
Topics: Adrenalectomy; Animals; Blood Glucose; Carboxy-Lyases; Diabetes Mellitus, Experimental; Glucagon; Insulin; Ketone Bodies; Kidney; Ornithine Decarboxylase; Rats; Streptozocin | 1980 |
Increased ATP inhibition of liver phosphofructokinase from genetically diabetic mice.
Topics: Adenosine Triphosphate; Animals; Diabetes Mellitus, Experimental; Glucagon; Isoenzymes; Kinetics; Liver; Mice; Phosphofructokinase-1 | 1980 |
Androgen sensitization of streptozotocin-induced diabetes in mice.
Topics: Anilides; Animals; Castration; Diabetes Mellitus, Experimental; Drug Synergism; Estrogens; Female; Flutamide; Glucagon; Insulin; Islets of Langerhans; Male; Mice; Mice, Inbred DBA; Sex Factors; Species Specificity; Streptozocin; Testosterone | 1980 |
Diabetes induced with multiple subdiabetogenic doses of streptozotocin: lack of protection by exogenous superoxide dismutase.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucagon; Half-Life; Insulin; Male; Mice; Pancreas; Streptozocin; Superoxide Dismutase | 1981 |
Long-term reversal of streptozotocin-induced diabetes in rats by intramuscular islet implantation.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Glucagon; Glucose Tolerance Test; Insulin; Islets of Langerhans Transplantation; Long-Term Care; Male; Rats; Rats, Inbred Lew; Streptozocin | 1981 |
The acute effects of streptozotocin-induced diabetes on rat liver glycerolipid biosynthesis.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Fatty Acids, Nonesterified; Glucagon; Glycerides; Insulin, Long-Acting; Kinetics; Liver; Male; Rats; Rats, Inbred Strains; Streptozocin; Triglycerides | 1981 |
Effect of pancreas transplantation on plasma lipids and plasma concentrations of pancreatic hormones in streptozotocin diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Glucagon; Insulin; Lipids; Lipoproteins; Male; Pancreas Transplantation; Pancreatic Hormones; Pancreatic Polypeptide; Random Allocation; Rats; Rats, Inbred Strains; Streptozocin; Triglycerides | 1981 |
Glucagon secretion in rats with non-insulin-dependent diabetes: an in vivo and in vitro study.
Topics: Animals; Arginine; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucagon; In Vitro Techniques; Male; Pancreas; Rats; Rats, Inbred Strains | 1984 |
Long-term effect of pancreas transplantation on diabetic hyperglucagonemia.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucagon; Immunologic Techniques; Insulin; Male; Pancreas Transplantation; Rats; Rats, Inbred Strains; Time Factors | 1982 |
Impaired insulin secretion in the spontaneous diabetes rats.
Topics: Animals; Arginine; Diabetes Mellitus, Experimental; Glucagon; Glucose; Insulin; Insulin Secretion; Norepinephrine; Rats | 1982 |
Progressive loss of sensitivity of the A cell to insulin in geese made diabetic by subtotal pancreatectomy.
Topics: Animals; Diabetes Mellitus, Experimental; Geese; Glucagon; Glucose Tolerance Test; Insulin; Islets of Langerhans; Pancreatectomy | 1982 |
Influence of insulin and glucagon on the production of glomerulopressin by isolated rat liver.
Topics: Animals; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Fasting; Glucagon; Glucuronates; Insulin; Liver; Perfusion; Rats; Rats, Inbred Strains | 1982 |
The Chinese hamster as a model for the study of diabetes mellitus.
Topics: Animals; Blood Glucose; Cricetinae; Cricetulus; Diabetes Mellitus, Experimental; Disease Models, Animal; Glucagon; Insulin; Pancreas | 1982 |
Modulation of hepatic reticuloendothelial system phagocytosis by pancreatic hormones.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Glucagon; Insulin; Kupffer Cells; Liver; Male; Mononuclear Phagocyte System; Pancreatic Hormones; Phagocytosis; Rats | 1982 |
Effects of intraportal islet transplantation on the transplanted tissue and the recipient pancreas. I. Functional studies.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Glucagon; Glucose Tolerance Test; Injections, Intravenous; Insulin; Insulin Secretion; Islets of Langerhans; Islets of Langerhans Transplantation; Liver; Male; Pancreas; Portal Vein; Rats; Rats, Inbred Strains; Time Factors; Transplantation, Homologous | 1980 |
Transplantation of cryopreserved pancreatic islets into the portal vein.
Topics: Animals; Diabetes Mellitus, Experimental; Dimethyl Sulfoxide; Freezing; Glucagon; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Islets of Langerhans Transplantation; Male; Portal Vein; Rats; Tissue Preservation | 1981 |
The role of insulin in atherosclerosis in diabetics and nondiabetics: a review.
Topics: Animals; Aorta; Arteriosclerosis; Cell Division; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetic Angiopathies; DNA Replication; Glucagon; Haplorhini; Humans; Insulin; Lipid Metabolism; Rats | 1981 |
[Islet cell transplantation: present status and perspectives].
Topics: Animals; Blood Glucose; Culture Techniques; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Diabetic Nephropathies; Diabetic Retinopathy; Freezing; Glucagon; Humans; Insulin; Islets of Langerhans Transplantation; Liver; Rats; Spleen; Tissue Banks | 1981 |
Effects of in vivo hormonal treatment on serine metabolism in isolated rat hepatocytes.
Topics: Animals; Diabetes Mellitus, Experimental; Glucagon; Hydrocortisone; L-Serine Dehydratase; Liver; Picolinic Acids; Quinolinic Acids; Rats; Serine; Transaminases | 1982 |
Streptozotocin diabetes results in increased responsiveness of adipocyte lipolysis to glucagon.
Topics: Adipose Tissue; Animals; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Glucagon; Lipolysis; Male; Rats; Rats, Inbred Strains; Time Factors | 1983 |
Arginine-induced glucagon secretion in the spontaneously diabetic BB Wistar rat.
Topics: Animals; Arginine; Blood Glucose; Diabetes Mellitus, Experimental; Female; Glucagon; Male; Rats; Rats, Inbred Strains | 1983 |
Lack of glucagon response to hypoglycemia in long-term experimental diabetic rats.
Topics: Aging; Animals; Diabetes Mellitus, Experimental; Epinephrine; Glucagon; Hypoglycemia; Male; Norepinephrine; Rats; Rats, Inbred Strains | 1983 |
[The development of a counterregulatory system for an artificial endocrine pancreas--invention of glucose and glucagon infusion algorithms].
Topics: Animals; Diabetes Mellitus, Experimental; Dogs; Evaluation Studies as Topic; Glucagon; Glucose; Insulin Infusion Systems; Monitoring, Physiologic | 1983 |
Effects of metabolic inhibitors on the regulation of pancreatic glucagon release.
Topics: Adenosine Triphosphate; Animals; Diabetes Mellitus, Experimental; Dinitrophenols; Glucagon; Guinea Pigs; In Vitro Techniques; Iodoacetates; Islets of Langerhans; Male; Malonates | 1980 |
Metabolic and hormonal investigations in long-term streptozotocin diabetic rats on different dietary regimens.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diet, Diabetic; Dietary Carbohydrates; Dietary Fats; Dietary Proteins; Energy Intake; Glucagon; Insulin; Islets of Langerhans; Kinetics; Lipids; Male; Rats | 1980 |
Glucagon and diabetes: evidence for marked insensitivity to local regulation of A-cell function by endogenous insulin in obese-hyperglycaemic (ob/ob) mice [proceedings].
Topics: Animals; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Experimental; Glucagon; Homozygote; Hyperglycemia; Insulin; Mice; Mice, Obese; Obesity; Pancreas; Starvation | 1980 |
Metasomatotrophic diabetes and its induction: basal insulin secretion and insulin release responses to glucose, glucagon, arginine and meals.
Topics: Animals; Arginine; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Eating; Fasting; Glucagon; Glucose; Glucose Tolerance Test; Growth Hormone; Insulin; Insulin Secretion; Kinetics; Male | 1980 |
Morphine-induced hyperglycemia: role of insulin and glucagon.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Glucagon; Hyperglycemia; Insulin; Morphine | 1980 |
Differences in response of proteolytic activity in cardiac, skeletal and diaphragm muscles to hormones and catabolic conditions.
Topics: Animals; Diabetes Mellitus, Experimental; Diaphragm; Fasting; Glucagon; Heart; Hormones; Male; Muscles; Myocardium; Nephrotic Syndrome; Peptide Hydrolases; Rats; Triamcinolone Acetonide; Triiodothyronine | 1980 |
Effect of glucose and insulin on glucagon secretion in alloxan diabetic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Gastric Inhibitory Polypeptide; Glucagon; Glucose; Glucose Tolerance Test; In Vitro Techniques; Infusions, Parenteral; Insulin; Islets of Langerhans; Male; Pancreas; Perfusion; Rats | 1980 |
The metabolic and hormonal responses to glucose infusion in anaesthetized normal and diabetic dogs controlled by an artificial B-cell.
Topics: Animals; Artificial Organs; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Fatty Acids, Nonesterified; Glucagon; Glucose; Insulin; Islets of Langerhans; Lactates; Pancreatectomy; Pyruvates | 1980 |
Habituation of a mammary aplastic carcinoma on diabetic conditions.
Topics: Alloxan; Animals; Diabetes Mellitus, Experimental; Female; Glucagon; Insulin; Mammary Neoplasms, Experimental; Mice; Mice, Inbred CBA; Neoplasm Transplantation; Transplantation, Homologous | 1980 |
Effect of insulin on glucagon secretion mediated via glucose metabolism of pancreatic A cells in ducks.
Topics: Animals; Deoxyglucose; Diabetes Mellitus, Experimental; Ducks; Glucagon; Glucose; Glucose Tolerance Test; Insulin; Islets of Langerhans; Male | 1981 |
Induction of L-lysine-2-oxoglutarate reductase by glucagon and glucocorticoid in developing and adult rats: in vivo and in vitro studies.
Topics: Adrenal Glands; Age Factors; Animals; Cells, Cultured; Dactinomycin; Dexamethasone; Diabetes Mellitus, Experimental; Enzyme Induction; Fetus; Glucagon; Insulin; Liver; Male; Oxidoreductases Acting on CH-NH Group Donors; Rats; Saccharopine Dehydrogenases | 1980 |
Regulation of coenzyme A synthesis in heart muscle: effects of diabetes and fasting.
Topics: Alloxan; Animals; Coenzyme A; Diabetes Mellitus, Experimental; Fasting; Glucagon; Insulin; Kinetics; Male; Myocardium; Pantothenic Acid; Rats | 1981 |
Effect of Bordetella pertussis vaccine on glucagon secretion in normal and alloxan dogs.
Topics: Animals; Diabetes Mellitus, Experimental; Dogs; Glucagon; Glucose; Insulin; Insulin Secretion; Pertussis Vaccine | 1980 |
Glucagon in spontaneously diabetic KK mice.
Topics: Animals; Arginine; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Glucagon; Hyperglycemia; Insulin; Jejunum; Male; Mice; Organ Size; Pancreas; Stomach | 1981 |
Subcutaneous, isogeneic transplantation of duct-ligated pancreas in streptozotocin diabetic mice II. Hormone storage as a function of time and of the recipient's initial glycemic state.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Female; Glucagon; Glucose Tolerance Test; Insulin; Kinetics; Ligation; Mice; Pancreas; Pancreas Transplantation; Pancreatic Ducts; Transplantation, Homologous | 1981 |
Inhibition of stress induced hyperglucagonemia by administration of glucose in normal and alloxan-diabetic rat.
Topics: Animals; Blood Glucose; Corticosterone; Diabetes Mellitus, Experimental; Glucagon; Glucose; Insulin; Male; Rats; Stress, Physiological | 1981 |
Comparison of the metabolic responses to portal and peripheral infusions of insulin in diabetic dogs.
Topics: 3-Hydroxybutyric Acid; Alanine; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Glucagon; Glycerol; Hydroxybutyrates; Infusions, Parenteral; Insulin; Kinetics; Lactates; Lactic Acid; Portal Vein | 1981 |
Subcutaneous, isogeneic transplantation of duct-ligated pancreas in streptozotocin-diabetic mice. Relationships between carbohydrate tolerance and hormone content in transplant or host pancreas.
Topics: Animals; Diabetes Mellitus, Experimental; Diet; Female; Glucagon; Glucose; Glucose Tolerance Test; Insulin; Ligation; Mice; Pancreas; Pancreas Transplantation; Transplantation, Isogeneic | 1981 |
Role of pancreatic hormones in dietary induction of ornithine decarboxylase of rat liver.
Topics: Adrenalectomy; Amino Acids; Animals; Carboxy-Lyases; Circadian Rhythm; Diabetes Mellitus, Experimental; Diet; Enzyme Induction; Glucagon; Hypophysectomy; Insulin; Liver; Male; Ornithine Decarboxylase; Pancreatectomy; Rats; Rats, Inbred Strains; Starvation | 1981 |
Importance of glucagon in mediating epinephrine-induced hyperglycemia in alloxan-diabetic dogs.
Topics: Alloxan; Animals; Diabetes Mellitus, Experimental; Dogs; Epinephrine; Glucagon; Glucose; Hyperglycemia; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics | 1981 |
Bihormonal theory of diabetes gets solid backing.
Topics: Animals; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Experimental; Glucagon; Humans; Insulin; Insulin Secretion; Rats | 1982 |
Potassium ion concentration alters glucagon secretion independently of insulin secretion in the isolated rat pancreas.
Topics: Animals; Arginine; Diabetes Mellitus, Experimental; Glucagon; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Male; Perfusion; Potassium; Rats; Rats, Inbred Strains | 1982 |
Insulin and glucagon release in the diabetic Chinese hamster: differences among inbred sublines.
Topics: Animals; Arginine; Blood Glucose; Cricetinae; Cricetulus; Diabetes Mellitus, Experimental; Female; Glucagon; Glucose; Insulin; Male; Pancreas; Perfusion; Sex Factors; Species Specificity | 1982 |
Hepatic triacylglycerol lipase activities after induction of diabetes and administration of insulin or glucagon.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Fatty Acids, Nonesterified; Glucagon; Insulin; Lipase; Liver; Rats; Starvation | 1982 |
Insulin and glucagon binding and stimulation of amino acid transport in isolated hepatocytes from streptozotocin diabetic rats.
Topics: Aminoisobutyric Acids; Animals; Biological Transport; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Glucagon; Insulin; Kinetics; Male; Rats | 1982 |
Effects of an enkephalin analog on pancreatic endocrine function and glucose homeostasis in normal and diabetic dogs.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Dose-Response Relationship, Drug; Enkephalin, Methionine; Gastric Mucosa; Glucagon; Homeostasis; Naloxone; Pancreas | 1982 |
Comparison of peripheral and portal venous insulin administration on postprandial metabolic responses in alloxan-diabetic dogs. Effects of identical preprogrammed complex insulin infusion waveforms.
Topics: Alanine; Amino Acids, Branched-Chain; Animals; Diabetes Mellitus, Experimental; Dogs; Glucagon; Infusions, Parenteral; Insulin Infusion Systems; Lactates; Metabolic Clearance Rate; Peripheral Nerves; Portal Vein | 1982 |
Factors affecting tryptophan-induced hypoglycaemia in rats.
Topics: Adrenalectomy; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucagon; Hormones; Hypoglycemia; Lactates; Lactic Acid; Male; Rats; Rats, Inbred Strains; Time Factors; Tryptophan | 1982 |
Immunoreactive glucagon in nondiabetic and diabetic Macaca nigra.
Topics: Animals; Diabetes Mellitus, Experimental; Glucagon; Glucose; Macaca | 1981 |
The activation of pyruvate dehydrogenase in the perfused rat heart by adrenaline and other inotropic agents.
Topics: Animals; Calcium; Cardiotonic Agents; Diabetes Mellitus, Experimental; Enzyme Activation; Epinephrine; Glucagon; Heart; In Vitro Techniques; Isoproterenol; Male; Myocardium; Pyruvate Dehydrogenase Complex; Rats; Starvation | 1981 |
Phenylalanine metabolism in isolated rat liver cells. Effects of glucagon and diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Glucagon; In Vitro Techniques; Liver; Male; Methods; Phenylalanine; Phenylalanine Hydroxylase; Rats; Rats, Inbred Strains; Time Factors | 1981 |
Effects of diabetes on oxidative decarboxylation of branched-chain keto acids.
Topics: 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide); Amino Acids, Branched-Chain; Animals; Cell-Free System; Diabetes Mellitus, Experimental; Glucagon; In Vitro Techniques; Keto Acids; Ketone Oxidoreductases; Liver; Male; Mitochondria; Multienzyme Complexes; Rats | 1980 |
Interleukin 1 beta induces diabetes and fever in normal rats by nitric oxide via induction of different nitric oxide synthases.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Blood Glucose; Body Temperature; Body Weight; Corticosterone; Diabetes Mellitus, Experimental; Glucagon; Guanidines; Humans; Insulin; Interleukin-1; Isoenzymes; Leukocyte Count; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Inbred WKY; Recombinant Proteins; Weight Gain | 1994 |
Hormonal control of hepatic glutaminase.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Diabetes Mellitus, Experimental; Dietary Proteins; Endotoxins; Enzyme Activation; Enzyme Inhibitors; Ethers, Cyclic; Glucagon; Glutamic Acid; Glutaminase; Glutamine; Mitochondria, Liver; Okadaic Acid; Phosphates; Rats; Signal Transduction; Thionucleotides | 1995 |
[Hypoxic training stimulates new growth of pancreatic beta cells and slows development of diabetes mellitus in rats].
Topics: Animals; Diabetes Mellitus, Experimental; Female; Glucagon; Hypoxia; Insulin; Islets of Langerhans; Male; Physical Conditioning, Animal; Rats; Rats, Wistar; Somatostatin | 1995 |
Differential proliferation of somatostatin and glucagon cells in rat pancreatic islets submitted to various stimuli.
Topics: Adrenalectomy; Animals; Cell Division; Cysteamine; Diabetes Mellitus, Experimental; Glucagon; Hydrocortisone; Immunohistochemistry; Islets of Langerhans; Male; Microscopy, Electron; Microscopy, Immunoelectron; Rats; Rats, Wistar; Somatostatin | 1995 |
Gene therapy for diabetes mellitus in rats by hepatic expression of insulin.
Topics: Animals; Base Sequence; Blood Glucose; C-Peptide; Diabetes Mellitus, Experimental; Gene Expression; Genetic Therapy; Genetic Vectors; Glucagon; Insulin; Ketones; Liver; Male; Molecular Sequence Data; Rats; Recombinant Proteins; Retroviridae; Streptozocin; Survival Analysis; Transduction, Genetic | 1995 |
Altered glucose dependence of glucagon-like peptide I(7-36)-induced insulin secretion from the Zucker (fa/fa) rat pancreas.
Topics: Animals; Diabetes Mellitus, Experimental; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Glucose Tolerance Test; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Obesity; Peptide Fragments; Perfusion; Rats; Rats, Zucker | 1995 |
Salivary peptide P-C potentiates insulin release and inhibits glucagon release from isolated perfused pancreas of the diabetic GK rat.
Topics: Animals; Arginine; Diabetes Mellitus, Experimental; Glucagon; Immunohistochemistry; Insulin; Insulin Secretion; Male; Pancreas; Peptides; Rats; Rats, Wistar | 1995 |
Excessive glucose production, rather than insulin resistance, accounts for hyperglycaemia in recent-onset streptozotocin-diabetic rats.
Topics: Adipose Tissue; Adipose Tissue, Brown; Animals; Blood Glucose; Deoxyglucose; Diabetes Mellitus, Experimental; Fatty Acids, Nonesterified; Glucagon; Glucose; Glucose Clamp Technique; Glycogen; Glycolysis; Hyperglycemia; Insulin; Insulin Resistance; Liver; Liver Glycogen; Male; Muscle, Skeletal; Myocardium; Organ Specificity; Rats; Rats, Wistar; Reference Values | 1995 |
Regulation of argininosuccinate synthetase level by corticosteroid and pancreatic hormones during perinatal period.
Topics: Adrenal Cortex Hormones; Adrenalectomy; Animals; Animals, Newborn; Argininosuccinate Synthase; Cells, Cultured; Cytoplasm; Dexamethasone; Diabetes Mellitus, Experimental; Female; Glucagon; Hydrocortisone; Hypophysectomy; Liver; Male; Mitochondria, Liver; Pancreatic Hormones; Pregnancy; Rats; Rats, Wistar | 1995 |
GI hormonal changes in diabetes influence pancreatic cancer growth.
Topics: Animals; Cell Division; Diabetes Mellitus, Experimental; Gastrointestinal Hormones; Glucagon; Insulin; Insulin-Like Growth Factor I; Male; Mice; Pancreatic Neoplasms; Somatostatin; Streptozocin; Tumor Cells, Cultured | 1995 |
Endocrine cells in the rat pancreatic and bile duct system: alteration in diabetes.
Topics: Animals; Bile Ducts; Cholecystokinin; Diabetes Mellitus, Experimental; Glucagon; Immunoenzyme Techniques; Insulin; Islets of Langerhans; Male; Microscopy, Electron; Pancreatic Polypeptide; Rats; Rats, Sprague-Dawley; Serotonin; Somatostatin | 1994 |
In vivo and in vitro effects of adenosine-5'-O-(2-thiodiphosphate) on pancreatic hormones in dogs.
Topics: Adenosine Diphosphate; Animals; Diabetes Mellitus, Experimental; Dogs; Glucagon; In Vitro Techniques; Insulin; Insulin Secretion; Somatostatin; Thionucleotides | 1994 |
Catecholamine-induced cAMP response in streptozotocin-induced diabetic rat liver.
Topics: Adipose Tissue; Animals; Colforsin; Cyclic AMP; Diabetes Mellitus, Experimental; Emaciation; Epinephrine; Glucagon; Glucose; Insulin; Isoproterenol; Lactates; Lactic Acid; Liver; Male; Oxymetazoline; Phenylephrine; Propranolol; Pyruvates; Pyruvic Acid; Rats; Receptors, Adrenergic, beta; Streptozocin | 1994 |
Immunoneutralization of endogenous glucagon with monoclonal glucagon antibody normalizes hyperglycaemia in moderately streptozotocin-diabetic rats.
Topics: Animals; Antibodies, Monoclonal; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucagon; Hyperglycemia; Insulin; Male; Rats; Rats, Sprague-Dawley; Streptozocin | 1994 |
Defective insulin and glucagon secretion in isolated perfused pancreata of diabetic WBN/Kob rats.
Topics: Animals; Arginine; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Disease Susceptibility; Glucagon; Glucose Tolerance Test; In Vitro Techniques; Insulin; Insulin Secretion; Male; Pancreas; Perfusion; Rats; Rats, Inbred Strains; Rats, Wistar | 1995 |
Increase in somatostatin to glucagon ratio in islets of alloxan-diabetic dogs: effect of insulin-induced euglycemia.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Glucagon; Immunohistochemistry; Insulin; Islets of Langerhans; Pancreas; Reference Values; Somatostatin | 1993 |
[The vasopressin-, oxytocin- and corticoliberin-synthesizing structures of the hypothalamus in rats with diabetes mellitus under hypoxic exposures].
Topics: Adaptation, Physiological; Animals; Blood Glucose; Corticotropin-Releasing Hormone; Diabetes Mellitus, Experimental; Glucagon; Hypothalamus; Hypoxia; Insulin; Islets of Langerhans; Oxytocin; Rats; Rats, Wistar; Somatostatin; Vasopressins | 1993 |
Pancreatic peptide YY in alloxan diabetic mice.
Topics: Alloxan; Animals; Chromatography, High Pressure Liquid; Diabetes Mellitus, Experimental; Female; Glucagon; Immunochemistry; Immunohistochemistry; Mice; Peptide YY; Peptides; Radioimmunoassay | 1994 |
Dietary macronutrient composition influences tissue trace element accumulation in diabetic Sprague-Dawley rats.
Topics: Animals; Blood Glucose; Body Composition; Body Weight; Diabetes Mellitus, Experimental; Diet; Female; Glucagon; Hematocrit; Hyperphagia; Insulin; Liver; Magnesium; Male; Rats; Rats, Sprague-Dawley; Trace Elements | 1994 |
Insulin and glucagon modulate hepatic 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity by affecting immunoreactive protein levels.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Fasting; Glucagon; Hydroxymethylglutaryl CoA Reductases; Insulin; Male; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1994 |
[Protective effect of tetrandrine on pancreatic islet cells damaged by alloxan in rats].
Topics: Alkaloids; Alloxan; Animals; Benzylisoquinolines; Diabetes Mellitus, Experimental; Glucagon; Injections, Intraperitoneal; Insulin; Islets of Langerhans; Male; Rats; Rats, Wistar | 1994 |
Natural history of B-cell dysfunction in spontaneously diabetic Chinese hamsters.
Topics: Amyloid; Animals; Blood Glucose; Cricetinae; Cricetulus; Diabetes Mellitus, Experimental; Female; Glucagon; Glucose Tolerance Test; Hyperglycemia; Immunohistochemistry; Insulin; Islet Amyloid Polypeptide; Islets of Langerhans; Longitudinal Studies; Male; Pancreas | 1994 |
Gliclazide directly suppresses arginine-induced glucagon secretion.
Topics: Animals; Arginine; Cysteamine; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Drug Interactions; Gliclazide; Glucagon; Insulin; Insulin Secretion; Male; Pancreas; Rats; Rats, Wistar; Somatostatin; Streptozocin; Sulfonylurea Compounds | 1994 |
In vivo studies of UV-B-irradiated adult pig islets in diabetic mice.
Topics: Animals; Cyclosporine; Diabetes Mellitus, Experimental; Glucagon; Graft Survival; Insulin; Insulin Secretion; Islets of Langerhans Transplantation; Mice; Mice, Inbred Strains; Swine; Time Factors; Transplantation, Heterologous; Ultraviolet Rays | 1994 |
Effect of lithium on plasma glucose, insulin and glucagon in normal and streptozotocin-diabetic rats: role of glucagon in the hyperglycaemic response.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Disease Models, Animal; Glucagon; Hyperglycemia; Insulin; Lithium; Male; Rats; Rats, Wistar | 1994 |
Effects of metformin on glucose and glucagon regulated gluconeogenesis in cultured normal and diabetic hepatocytes.
Topics: Animals; Cells, Cultured; Diabetes Mellitus, Experimental; Glucagon; Gluconeogenesis; Glucose; Liver; Male; Metformin; Rats; Rats, Sprague-Dawley | 1994 |
Effects of alpha 2- and beta-adrenergic agonism on glucagon secretion from perfused pancreata of normal and streptozocin-induced diabetic rats.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Clonidine; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Glucagon; Glucose; Insulin; Insulin Secretion; Isoproterenol; Male; Norepinephrine; Pancreas; Propranolol; Radioimmunoassay; Rats; Rats, Wistar; Streptozocin; Yohimbine | 1993 |
Interaction of dietary protein and alpha-linolenic acid on polyunsaturated fatty acid composition of liver microsomal phospholipids and eicosanoid production in streptozotocin-induced diabetic rats.
Topics: alpha-Linolenic Acid; Animals; Arachidonic Acid; Blood Glucose; Caseins; Diabetes Mellitus, Experimental; Dietary Fats, Unsaturated; Dietary Proteins; Eicosanoids; Eicosapentaenoic Acid; Epoprostenol; Fatty Acids, Unsaturated; Glucagon; Insulin; Linolenic Acids; Male; Microsomes, Liver; Phospholipids; Plant Proteins, Dietary; Rats; Rats, Sprague-Dawley; Soybean Proteins; Thromboxane A2; Weight Gain | 1993 |
Na,K-ATPase in diabetic rat small intestine. Changes at protein and mRNA levels and role of glucagon.
Topics: Animals; Diabetes Mellitus, Experimental; Glucagon; Immunoblotting; Intestine, Small; Male; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sodium-Potassium-Exchanging ATPase; Streptozocin | 1994 |
Myocardial glucose transporters and glycolytic metabolism during ischemia in hyperglycemic diabetic swine.
Topics: Animals; Coronary Vessels; Deoxyglucose; Diabetes Mellitus, Experimental; Disease Models, Animal; Fatty Acids, Nonesterified; Female; Glucagon; Glucose; Glucose Transporter Type 4; Glycolysis; Hyperglycemia; Lactates; Microspheres; Monosaccharide Transport Proteins; Muscle Proteins; Myocardial Ischemia; Myocardium; Regional Blood Flow; Streptozocin; Swine | 1994 |
Restoration in vitro of normal rates of very-low-density lipoprotein triacylglycerol and apoprotein B secretion in hepatocyte cultures from diabetic rats.
Topics: Animals; Apolipoproteins B; Cells, Cultured; Diabetes Mellitus, Experimental; Glucagon; Insulin; Lipoproteins, VLDL; Liver; Male; Rats; Rats, Wistar; Triglycerides | 1993 |
Opposite effects of hyperglycemia and insulin deficiency on liver glycogen synthase phosphatase activity in the diabetic rat.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucagon; Glucokinase; Glucose; Glucose-6-Phosphatase; Glycogen-Synthase-D Phosphatase; Hexosephosphates; Hyperglycemia; Insulin; Liver; Male; Phlorhizin; Rats; Rats, Sprague-Dawley | 1993 |
Long-term diabetogenic effect of streptozotocin in rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucagon; Insulin; Insulin Secretion; Islets of Langerhans; Male; Rats; Rats, Sprague-Dawley; Streptozocin; Time Factors | 1993 |
The inhibitory action of buformin, a biguanide on gluconeogenesis from alanine and its transport system in rat livers.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Alanine; Animals; Biological Transport, Active; Buformin; Cell Separation; Diabetes Mellitus, Experimental; Glucagon; Gluconeogenesis; Hydroxybutyrates; Lactates; Lactic Acid; Liver; Male; Perfusion; Pyruvates; Pyruvic Acid; Rats; Rats, Wistar; Tolbutamide | 1993 |
Insulin stimulates cationic amino acid transport activity in the isolated perfused rat pancreas.
Topics: Amino Acids; Animals; Cell Membrane; Diabetes Mellitus, Experimental; Gastrointestinal Agents; Glucagon; Hypoglycemic Agents; In Vitro Techniques; Insulin; Kinetics; Lysine; Male; Oxygen Consumption; Pancreas; Rats; Rats, Sprague-Dawley; Stimulation, Chemical | 1995 |
Mechanism of impaired glucose-potentiated insulin secretion in diabetic 90% pancreatectomy rats. Study using glucagonlike peptide-1 (7-37).
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Drug Synergism; Fasting; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Hyperglycemia; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Organ Size; Pancreas; Pancreatectomy; Peptide Fragments; Peptides; Proinsulin; Rats; Rats, Sprague-Dawley; RNA, Messenger; Time Factors | 1996 |
Neurotransmitters partially restore glucose sensitivity of insulin and glucagon secretion from perfused streptozotocin-induced diabetic rat pancreas.
Topics: Acetylcholine; Animals; Diabetes Mellitus, Experimental; Glucagon; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Male; Neurotransmitter Agents; Norepinephrine; Pancreas; Perfusion; Rats; Rats, Wistar | 1995 |
Glucagon secretory response to hypoglycaemia, adrenaline and carbachol in streptozotocin-diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Carbachol; Diabetes Mellitus, Experimental; Drinking; Eating; Epinephrine; Glucagon; Hypoglycemia; Male; Rats; Rats, Sprague-Dawley; Receptors, Cholinergic | 1995 |
Evidence for a major role for glucagon in regulation of plasma glucose in conscious, nondiabetic, and alloxan-induced diabetic rabbits.
Topics: Alloxan; Animals; Antibodies, Monoclonal; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Glucagon; Immunization, Passive; Male; Rabbits | 1996 |
Glucagon response to hypoglycemia is improved by insulin-independent restoration of normoglycemia in diabetic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucagon; Hypoglycemia; Insulin; Male; Rats; Rats, Sprague-Dawley; Reference Values | 1996 |
Low level cyclic adenosine 3',5'-monophosphate accumulation analysis of [des-His1, des- Phe6, Glu9] glucagon-NH2 identifies glucagon antagonists from weak partial agonists/antagonists.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclase Inhibitors; Amrinone; Animals; Blood Glucose; Cyclic AMP; Diabetes Mellitus, Experimental; Glucagon; Liver; Male; Phosphodiesterase Inhibitors; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Rolipram | 1996 |
In vitro and in vivo insulinotropic action of methyl pyruvate.
Topics: Animals; Animals, Newborn; Blood Glucose; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Drug Interactions; Fasting; Female; Glucagon; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Pyruvates; Rats; Rats, Wistar | 1995 |
Diabetogenic effects of salmon calcitonin are attributable to amylin-like activity.
Topics: Amino Acid Sequence; Amyloid; Animals; Blood Glucose; Calcitonin; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Drug Synergism; Glucagon; Glycogen; Hindlimb; Injections, Intravenous; Insulin; Insulin Secretion; Islet Amyloid Polypeptide; Lactates; Lactic Acid; Male; Molecular Sequence Data; Muscle, Skeletal; Rats; Rats, Sprague-Dawley; Salmon; Sequence Homology, Amino Acid | 1995 |
Glucosamine-induced inhibition of liver glucokinase impairs the ability of hyperglycemia to suppress endogenous glucose production.
Topics: Animals; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Experimental; Glucagon; Glucokinase; Glucosamine; Glucose; Glucose Clamp Technique; Humans; Hyperglycemia; Infusions, Intravenous; Insulin; Kinetics; Lactates; Liver; Male; Rats; Rats, Sprague-Dawley; Somatostatin; Uridine Diphosphate Glucose; Uridine Diphosphate N-Acetylglucosamine | 1996 |
Reinnervation of pancreatic islets and regulation of insulin secretion by hepatic sympathetic nerves after intraportal transplantation of islets into livers of diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Electric Stimulation; Glucagon; Insulin; Islets of Langerhans; Islets of Langerhans Transplantation; Liver; Liver Circulation; Portal Vein; Rats; Sympathetic Nervous System | 1995 |
Hyperproliferative state of liver acini and pancreatic islets after intraportal transplantation of a small mass of islets of Langerhans in streptozotocininduced diabetic rats.
Topics: Animals; Apoptosis; Blood Glucose; Bromodeoxyuridine; Cell Transplantation; Diabetes Mellitus, Experimental; Glucagon; Immunohistochemistry; Insulin; Islets of Langerhans; Islets of Langerhans Transplantation; Liver; Male; Mitosis; Portal Vein; Rats; Rats, Inbred Lew; Weight Gain | 1995 |
A rapid- and short-acting hypoglycemic agent KAD-1229 improves post-prandial hyperglycemia and diabetic complications in streptozotocin-induced non-insulin-dependent diabetes mellitus rats.
Topics: Albuminuria; Analysis of Variance; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucagon; Hyperglycemia; Hypoglycemic Agents; Indoles; Insulin; Isoindoles; Male; Pancreas; Rats; Rats, Sprague-Dawley; Streptozocin | 1996 |
Decreased glucose-induced cAMP and insulin release in islets of diabetic rats: reversal by IBMX, glucagon, GIP.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Brimonidine Tartrate; Cyclic AMP; Diabetes Mellitus, Experimental; Dinoprostone; Galanin; Gastric Inhibitory Polypeptide; Glucagon; Insulin; Insulin Secretion; Islets of Langerhans; Quinoxalines; Rats; Rats, Wistar; Secretory Rate; Somatostatin | 1996 |
Potentiation of GLP-1 insulinotropic action by a nonglucidic nutrient in the pancreas of diabetic GK rats.
Topics: Animals; Diabetes Mellitus, Experimental; Drug Synergism; Glucagon; Glucagon-Like Peptide 1; Insulin; Male; Pancreas; Peptide Fragments; Protein Precursors; Rats; Succinates | 1996 |
Long-term metabolic control by rat islet grafts depends on the composition of the implant.
Topics: Aging; Animals; Blood Glucose; Cell Count; Diabetes Mellitus, Experimental; Fructosamine; Glucagon; Glucose Tolerance Test; Insulin; Islets of Langerhans; Islets of Langerhans Transplantation; Kidney; Liver; Male; Portal Vein; Rats; Rats, Inbred Lew; Time Factors; Transplantation, Heterotopic | 1996 |
Differential effects of streptozotocin-induced diabetes on phenylalanine hydroxylase protein and mRNA abundance in isolated rat liver cells.
Topics: Animals; Blotting, Northern; Cells, Cultured; Dexamethasone; Diabetes Mellitus, Experimental; Gene Expression Regulation, Enzymologic; Glucagon; Immunoblotting; Insulin; Kidney; Liver; Male; Phenylalanine Hydroxylase; Phosphoenolpyruvate Carboxylase; Rats; Rats, Wistar; RNA, Messenger | 1996 |
Mechanisms of postabsorptive hyperglycemia in streptozotocin diabetic rats.
Topics: Absorption; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucagon; Glucose; Glycogen; Glycosuria; Hyperglycemia; Insulin; Liver; Male; Phlorhizin; Rats; Rats, Wistar; Time Factors | 1996 |
Short-term insulin treatment prevents the diabetogenic action of streptozotocin in rats.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Female; Glucagon; Glucose Transporter Type 2; Immunohistochemistry; Insulin; Monosaccharide Transport Proteins; Pancreas; Rats; Rats, Wistar; Streptozocin | 1997 |
The effect of pioglitazone on hepatic glucose uptake measured with indirect and direct methods in alloxan-induced diabetic dogs.
Topics: Animals; Biological Transport; Blood Pressure; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Dogs; Glucagon; Glucose; Hypoglycemic Agents; Insulin; Insulin Resistance; Liver; Pioglitazone; Thiazoles; Thiazolidinediones | 1997 |
Insulin resistance prevented by portal delivery of insulin in rats with renal subcapsular islet grafts.
Topics: Anastomosis, Surgical; Animals; Blood Glucose; C-Peptide; Diabetes Mellitus, Experimental; Glucagon; Glucose Clamp Technique; Hyperinsulinism; Infusions, Intravenous; Insulin; Insulin Resistance; Insulin Secretion; Islets of Langerhans Transplantation; Liver; Male; Mesenteric Veins; Organ Size; Rats; Rats, Inbred Lew; Renal Veins | 1997 |
Extrapancreatic islets of Langerhans: ontogenesis and alterations in diabetic condition.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Duodenum; Glucagon; Immunohistochemistry; Insulin; Intestinal Mucosa; Islets of Langerhans; Male; Microscopy, Electron; Rats; Rats, Inbred BB; Rats, Sprague-Dawley | 1997 |
Increased alanine uptake and lipid synthesis from alanine in isolated hepatocytes of Wistar-Kyoto fatty rats: an inhibitory effect of biguanides.
Topics: Aging; Alanine; Animals; Body Weight; Buformin; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Glucagon; Hypoglycemic Agents; Lipids; Liver; Male; Metformin; Rats; Rats, Inbred WKY | 1997 |
Analysis of the possible protective role of metallothionein in streptozotocin-induced diabetes using metallothionein-null mice.
Topics: Analysis of Variance; Animals; Blood Glucose; Crosses, Genetic; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Female; Glucagon; Insulin; Metallothionein; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Knockout; Mice, Transgenic; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Zinc | 1997 |
Demonstration of two different processes of beta-cell regeneration in a new diabetic mouse model induced by selective perfusion of alloxan.
Topics: Alloxan; Animals; Blood Glucose; Body Weight; Cell Division; Diabetes Mellitus, Experimental; Disease Models, Animal; Glucagon; Glucose Tolerance Test; Homeodomain Proteins; Immunohistochemistry; Insulin; Islets of Langerhans; Keratins; Male; Mice; Mice, Inbred ICR; Pancreatic Polypeptide; Perfusion; Regeneration; Somatostatin; Time Factors; Trans-Activators | 1997 |
The diabetogenic effects of acute verapamil poisoning.
Topics: Animals; Diabetes Mellitus, Experimental; Dogs; Female; Glucagon; Glucose; Hyperglycemia; Infusions, Intravenous; Insulin; Insulin Antagonists; Male; Sodium Chloride; Verapamil | 1997 |
Gut and liver fat metabolism in depancreatized dogs: effects of exercise and acute insulin infusion.
Topics: Adipose Tissue; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Digestive System; Dogs; Fatty Acids, Nonesterified; Female; Glucagon; Hypoglycemic Agents; Insulin; Ketone Bodies; Lipid Metabolism; Liver; Liver Circulation; Male; Pancreatectomy; Physical Exertion | 1997 |
The endocrine pancreas in virgin and pregnant offspring of diabetic pregnant rats.
Topics: Animals; Blood Glucose; Cell Count; Cell Size; Diabetes Mellitus, Experimental; Female; Glucagon; Insulin; Islets of Langerhans; Male; Pancreatic Polypeptide; Pregnancy; Pregnancy in Diabetics; Pregnancy, Animal; Rats; Rats, Wistar; Somatostatin; Tissue Distribution | 1997 |
Length of metabolic normalization after rat islet cell transplantation depends on endocrine cell composition of graft and on donor age.
Topics: Age Factors; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Fructosamine; Glucagon; Graft Survival; Insulin; Islets of Langerhans Transplantation; Liver; Male; Pancreas; Rats; Rats, Inbred Lew; Time Factors | 1997 |
Intestinal growth is associated with elevated levels of glucagon-like peptide 2 in diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Gastrointestinal Hormones; Glicentin; Glucagon; Glucagon-Like Peptide 2; Glucagon-Like Peptides; Insulin; Intestine, Small; Male; Organ Size; Organ Specificity; Oxyntomodulin; Peptide Fragments; Peptides; Proglucagon; Protein Precursors; Rats; Rats, Wistar; Time Factors | 1997 |
The effect on plasma glucose, insulin and glucagon levels of treatment of diabetic rats with the medicinal plant Rhazya stricta and with glibenclamide, alone and in combination.
Topics: Animals; Blood Glucose; Cholesterol; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Drug Interactions; Glucagon; Glyburide; Hypoglycemic Agents; Insulin; Male; Plant Extracts; Plants, Medicinal; Rats; Rats, Wistar | 1997 |
Changes in plasma glucose, insulin, glucagon, catecholamine, and glycogen contents in tissues during development of alloxan diabetes mellitus in rats.
Topics: Alloxan; Animals; Blood Glucose; Catecholamines; Diabetes Mellitus, Experimental; Glucagon; Glycogen; Insulin; Male; Rats; Rats, Wistar | 1997 |
Cryopreservation of rat pancreatic islets: effect of ethylene glycol on islet function and cellular composition.
Topics: Animals; Blood Glucose; Cell Separation; Cryopreservation; Diabetes Mellitus, Experimental; Dimethyl Sulfoxide; DNA; Ethylene Glycols; Glucagon; Glucose; Glucose Tolerance Test; Humans; Insulin; Insulin Secretion; Islets of Langerhans; Islets of Langerhans Transplantation; Male; Rats; Rats, Inbred WF; Tissue Preservation | 1997 |
Regulation of hepatic glutaminase in the streptozotocin-induced diabetic rat.
Topics: Animals; Carbon Dioxide; Carbon Radioisotopes; Diabetes Mellitus, Experimental; Epinephrine; Glucagon; Glutaminase; Glutamine; Kinetics; Liver; Male; Mitochondria, Liver; Rats; Rats, Sprague-Dawley | 1997 |
Glucagon-like peptide-1(7-36)-amide confers glucose sensitivity to previously glucose-incompetent beta-cells in diabetic rats: in vivo and in vitro studies.
Topics: Animals; Culture Techniques; Cyclic AMP; Diabetes Mellitus, Experimental; DNA; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Glucose Tolerance Test; Insulin; Insulin Secretion; Islets of Langerhans; Male; Neurotransmitter Agents; Peptide Fragments; Perfusion; Rats; Rats, Wistar | 1997 |
Effects of ketamine sedation on glucose clearance, insulin secretion and counterregulatory hormone production in baboons (Papio hamadryas).
Topics: Anesthetics, Dissociative; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Glucagon; Glucose; Glucose Tolerance Test; Hydrocortisone; Insulin; Ketamine; Male; Papio | 1997 |
Experimental pancreas transplantation: the consequences of portocaval shunt on blood glucose, plasma insulin, and glucagon.
Topics: Anastomosis, Surgical; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucagon; Graft Survival; Insulin; Male; Pancreas Transplantation; Portal System; Rats; Rats, Wistar; Transplantation, Isogeneic | 1998 |
Effects of glucagon-like peptide 1 on the kinetics of glycogen synthase a in hepatocytes from normal and diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Glucagon; Glucagon-Like Peptide 1; Glucose; Glycogen Synthase; Isoenzymes; Kinetics; Liver; Male; Peptide Fragments; Phosphorylase a; Protein Precursors; Rats; Rats, Wistar; Reference Values | 1998 |
Glucose turnover and insulin sensitivity in rats with pancreatic islet transplants.
Topics: Anastomosis, Surgical; Animals; Blood Glucose; C-Peptide; Diabetes Mellitus, Experimental; Food; Glucagon; Glucose; Glucose Tolerance Test; Insulin; Insulin Resistance; Islets of Langerhans Transplantation; Kidney; Liver; Male; Mesenteric Veins; Rats; Rats, Inbred Lew; Renal Veins | 1998 |
Quantitative measurement of islet glucagon response to hypoglycemia by confocal fluorescence imaging in diabetic rats: effects of phlorizin treatment.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Fluorescent Antibody Technique, Direct; gamma-Aminobutyric Acid; Glucagon; Hypoglycemia; Hypoglycemic Agents; Image Processing, Computer-Assisted; Insulin; Islets of Langerhans; Male; Microscopy, Confocal; Phlorhizin; Rats; Rats, Sprague-Dawley | 1997 |
Insulin, but not glucose lowering corrects the hyperglucagonemia and increased proglucagon messenger ribonucleic acid levels observed in insulinopenic diabetes.
Topics: Animals; Blood Glucose; Blotting, Northern; Diabetes Mellitus, Experimental; Female; Gene Expression; Glucagon; Glucose; Insulin; Pancreas; Proglucagon; Protein Precursors; Rats; Rats, Wistar; Ribonucleases; RNA, Messenger | 1998 |
Effects of islet hormones on nerve-mediated and acetylcholine-evoked secretory responses in the isolated pancreas of normal and diabetic rats.
Topics: Acetylcholine; Acetylcholinesterase; Amylases; Animals; Calcium; Diabetes Mellitus, Experimental; Electric Stimulation; Female; Glucagon; Immunohistochemistry; In Vitro Techniques; Insulin; Neurons; Pancreas; Pancreatic Hormones; Rats; Rats, Sprague-Dawley; Somatostatin | 1998 |
Monitoring human islet allografts using a forearm biopsy site.
Topics: Animals; Biopsy, Needle; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Forearm; Glucagon; Humans; Insulin; Islets of Langerhans Transplantation; Lymphocytes; Mice; Mice, SCID; Monitoring, Physiologic; Transplantation, Heterotopic; Transplantation, Homologous | 1997 |
Evaluation of immunoisolated insulin-secreting beta TC6-F7 cells as a bioartificial pancreas.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blood Glucose; Capsules; Cell Division; Cell Separation; Diabetes Mellitus, Experimental; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Insulin; Insulin Secretion; Insulinoma; Pancreas, Artificial; Pancreatic Neoplasms; Peptide Fragments; Protein Precursors; Rats; Rats, Wistar; Time Factors; Tumor Cells, Cultured | 1997 |
Increased glucagon-stimulated insulin secretion of cryopreserved rat islets transplanted into nude mice.
Topics: Animals; Blood Glucose; Body Weight; Cryopreservation; Diabetes Mellitus, Experimental; Glucagon; Insulin; Insulin Secretion; Islets of Langerhans; Islets of Langerhans Transplantation; Male; Mice; Mice, Nude; Rats; Rats, Wistar | 1999 |
Increased dependence of glucose production on peripheral insulin in diabetic depancreatized dogs.
Topics: Alanine; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Fatty Acids, Nonesterified; Glucagon; Glucose; Glycerol; Hypoglycemic Agents; Insulin; Liver; Male; Pancreatectomy | 1999 |
An insulin-dependent hypoglycaemia induced by electroacupuncture at the Zhongwan (CV12) acupoint in diabetic rats.
Topics: Acupuncture Points; Animals; beta-Endorphin; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Electroacupuncture; Glucagon; Hypoglycemia; Insulin; Insulin Resistance; Male; Naloxone; Narcotic Antagonists; Rats; Rats, Wistar; Tolbutamide | 1999 |
Lipoic acid acutely induces hypoglycemia in fasting nondiabetic and diabetic rats.
Topics: 3-Hydroxybutyric Acid; Alanine; Animals; Blood Glucose; Carnitine; Diabetes Mellitus, Experimental; Fasting; Fatty Acids, Nonesterified; Glucagon; Gluconeogenesis; Hypoglycemia; Liver; Male; Pyruvic Acid; Rats; Rats, Sprague-Dawley; Thioctic Acid | 1999 |
Interaction of islet hormones with cholecystokinin octapeptide-evoked secretory responses in the isolated pancreas of normal and diabetic rats.
Topics: Amylases; Animals; Calcium; Diabetes Mellitus, Experimental; Female; Fluorescent Dyes; Fura-2; Glucagon; Hypoglycemic Agents; Immunohistochemistry; In Vitro Techniques; Insulin; Islets of Langerhans; Male; Pancreas; Pancreatic Hormones; Rats; Rats, Sprague-Dawley; Sincalide | 1999 |
Splanchnic glucagon kinetics in exercising alloxan-diabetic dogs.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Glucagon; Hepatic Veins; Insulin; Kinetics; Liver; Physical Exertion; Portal Vein; Splanchnic Circulation | 1999 |
Glucagon-like peptide 1 increases insulin sensitivity in depancreatized dogs.
Topics: Adipose Tissue; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dogs; Fatty Acids, Nonesterified; Female; Gene Expression; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose Clamp Technique; Glycerol; Insulin; Insulin Secretion; Kinetics; Male; Pancreatectomy; Peptide Fragments; Protein Precursors; Receptors, Glucagon; Reverse Transcriptase Polymerase Chain Reaction; Somatostatin | 1999 |
Effect of subcutaneous pancreatic tissue transplants on streptozotocin-induced diabetes in rats. II. Endocrine and metabolic functions.
Topics: Analysis of Variance; Animals; Blood Glucose; Body Weight; C-Peptide; Cholesterol; Diabetes Mellitus, Experimental; Endocrine System; Female; Glucagon; Glycated Hemoglobin; Insulin; Male; Pancreas Transplantation; Rats; Rats, Wistar; Skin; Transplantation, Heterologous | 1999 |
Effect of subcutaneous pancreatic tissue transplants on streptozotocin-induced diabetes in rats. I. Morphological studies on normal, diabetic and transplanted pancreatic tissues.
Topics: Animals; Diabetes Mellitus, Experimental; Female; Glucagon; Immunohistochemistry; Insulin; Male; Pancreas Transplantation; Rats; Rats, Wistar; Reference Values; Skin; Somatostatin; Transplantation, Heterologous | 1999 |
Regulation of homocysteine metabolism.
Topics: Animals; Diabetes Mellitus, Experimental; Glucagon; Homocysteine; Humans; In Vitro Techniques; Insulin; Kidney; Kidney Diseases; Liver; Male; Methylation; Rats; Rats, Sprague-Dawley; Sulfur; Tissue Distribution | 1999 |
[Inhibition of incretin degradation--a new therapy principle for treatment of type 2 diabetes?].
Topics: Administration, Oral; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Enzyme Inhibitors; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Hypoglycemic Agents; Isoleucine; Peptide Fragments; Rats; Rats, Zucker; Thiazoles | 1999 |
Vasopressin and urinary concentrating activity in diabetes mellitus.
Topics: Animals; Blood Glucose; Body Weight; Creatinine; Diabetes Mellitus, Experimental; Diuresis; Drinking Behavior; Glucagon; Glycosuria; Kidney Concentrating Ability; Male; Potassium; Rats; Rats, Wistar; Sodium; Urea; Vasopressins | 1999 |
Effects of cryopreservation on in vitro and in vivo long-term function of human islets.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arginine; Cryopreservation; Diabetes Mellitus, Experimental; Glucagon; Glucose; Glucose Tolerance Test; Humans; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Islets of Langerhans Transplantation; Male; Mice; Mice, Nude; Reference Values; Time Factors; Transplantation, Heterologous | 1999 |
Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats.
Topics: Animals; Blood Glucose; Cell Division; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Exenatide; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Insulin; Islets of Langerhans; Male; Pancreatectomy; Peptide Fragments; Peptides; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Glucagon; Venoms | 1999 |
Distribution of calcitonin-gene-related peptide, neuropeptide-Y, vasoactive intestinal polypeptide, cholecystokinin-8, substance P and islet peptides in the pancreas of normal and diabetic rats.
Topics: Animals; Antibody Specificity; Calcitonin Gene-Related Peptide; Diabetes Mellitus, Experimental; Glucagon; Insulin; Nerve Fibers; Neuropeptide Y; Neuropeptides; Pancreas; Pancreatic Hormones; Pancreatic Polypeptide; Rats; Sincalide; Somatostatin; Substance P; Vasoactive Intestinal Peptide | 1999 |
Hepatic alpha- and beta-adrenergic receptors are not essential for the increase in R(a) during exercise in diabetes.
Topics: Animals; Arteries; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Epinephrine; Female; Glucagon; Gluconeogenesis; Glucose; Hydrocortisone; Insulin; Kinetics; Liver; Male; Norepinephrine; Physical Conditioning, Animal; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta | 2000 |
Regulation of pancreatic PC1 and PC2 associated with increased glucagon-like peptide 1 in diabetic rats.
Topics: Animals; Aspartic Acid Endopeptidases; Body Weight; Diabetes Mellitus, Experimental; Glucagon; Glucagon-Like Peptide 1; Immunohistochemistry; Insulin; Islets of Langerhans; Male; Pancreas; Peptide Fragments; Proinsulin; Proprotein Convertase 2; Proprotein Convertases; Protein Precursors; Rats; Rats, Wistar; RNA, Messenger; Streptozocin; Subtilisins | 2000 |
Expression of pancreatic islet MHC class I, insulin, and ICA 512 tyrosine phosphatase in low-dose streptozotocin-induced diabetes in mice.
Topics: Animals; Autoantigens; Blood Glucose; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Glucagon; H-2 Antigens; Humans; Insulin; Islets of Langerhans; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Protein Tyrosine Phosphatases; Rabbits; Receptor-Like Protein Tyrosine Phosphatases, Class 8; Streptozocin | 2000 |
Effect of JTT-501 on net hepatic glucose balance and peripheral glucose uptake in alloxan-induced diabetic dogs.
Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Glucagon; Glucose; Hypoglycemic Agents; Insulin; Isoxazoles; Liver; Male | 2000 |
The gene for hepatocyte nuclear factor (HNF)-4alpha is activated by glucocorticoids and glucagon, and repressed by insulin in rat liver.
Topics: Animals; Blotting, Western; Cells, Cultured; Dexamethasone; Diabetes Mellitus, Experimental; DNA-Binding Proteins; Gene Expression Regulation; Glucagon; Glucose; Hepatocyte Nuclear Factor 4; Insulin; Insulin Antagonists; Liver; Male; Phosphoproteins; Rats; Rats, Wistar; RNA, Messenger; Transcription Factors; Transcriptional Activation | 2000 |
Prolongation of the insulinotropic action of glucagon-like peptide 1 by the dimethyl ester of succinic acid in an animal model of type-2 diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Insulin; Male; Pancreas; Peptide Fragments; Protein Precursors; Rats; Succinates | 2000 |
Increased responses of glucagon and glucose production to hypoglycemia with intraperitoneal versus subcutaneous insulin treatment.
Topics: Animals; Blood Glucose; Delayed-Action Preparations; Diabetes Mellitus, Experimental; Epinephrine; Glucagon; Glucose; Hypoglycemia; Hypoglycemic Agents; Injections, Intraperitoneal; Injections, Subcutaneous; Insulin; Male; Norepinephrine; Rats; Rats, Sprague-Dawley | 2000 |
Distribution of neurotransmitters and their effects on glucagon secretion from the in vitro normal and diabetic pancreatic tissues.
Topics: Acetylcholine; Animals; Biogenic Monoamines; Choline O-Acetyltransferase; Diabetes Mellitus, Experimental; gamma-Aminobutyric Acid; Glucagon; In Vitro Techniques; Neurotransmitter Agents; Pancreas; Rats; Rats, Wistar; Tyrosine 3-Monooxygenase | 2000 |
Distribution of NPY and SP and their effects on glucagon secretion from the in vitro normal and diabetic pancreatic tissues.
Topics: Animals; Culture Techniques; Diabetes Mellitus, Experimental; Glucagon; Immunohistochemistry; Islets of Langerhans; Male; Neuropeptide Y; Pancreas; Radioimmunoassay; Rats; Rats, Wistar; Substance P | 2000 |
IFN-gamma overexpression within the pancreas is not sufficient to rescue Pax4, Pax6, and Pdx-1 mutant mice from death.
Topics: Animals; Diabetes Mellitus, Experimental; Eye Proteins; Female; Glucagon; Homeodomain Proteins; Interferon-gamma; Islets of Langerhans; Male; Mice; Mice, Knockout; Mutation; Paired Box Transcription Factors; PAX6 Transcription Factor; Regeneration; Repressor Proteins; Trans-Activators; Transcription Factors | 2000 |
Impaired neural regulation of insulin secretion related to the leptin receptor gene mutation in Wistar fatty rats.
Topics: Animals; Atropine Derivatives; Blood Glucose; Carrier Proteins; Crosses, Genetic; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, Animal; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Injections, Intraventricular; Insulin; Insulin Resistance; Insulin Secretion; Mutation; Obesity; Peptide Fragments; Protein Precursors; Rats; Rats, Inbred WKY; Rats, Zucker; Receptors, Cell Surface; Receptors, Leptin; Vagotomy; Vagus Nerve | 2000 |
Effect of subcutaneous pancreatic tissue transplants on host pancreatic tissue levels of insulin and glucagon in the diabetic rat.
Topics: Animals; Diabetes Mellitus, Experimental; Glucagon; Insulin; Pancreas Transplantation; Rats; Reference Values; Skin; Transplantation, Heterotopic | 2000 |
Relationship between endocrine function and digital image quantitation of the pancreatic insulin- and glucagon-positive cell masses in normal, alloxan-diabetic, and heterotopic pancreas-transplanted rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucagon; Immunohistochemistry; Insulin; Islets of Langerhans; Male; Pancreas Transplantation; Rats; Rats, Inbred Lew; Software; Transplantation, Heterotopic; Transplantation, Isogeneic | 2000 |
Early changes in islet hormone secretion in the hamster pancreatic cancer model.
Topics: Adenocarcinoma; Amyloid; Animals; Carcinogens; Cricetinae; Diabetes Mellitus, Experimental; Disease Models, Animal; Glucagon; Glucose Tolerance Test; Insulin; Insulin Resistance; Insulin Secretion; Islet Amyloid Polypeptide; Islets of Langerhans; Male; Mesocricetus; Nitrosamines; Pancreatic Juice; Pancreatic Neoplasms; Somatostatin | 2001 |
Distribution of vasoactive intestinal polypeptide and its effect on glucagon secretion from normal and diabetic pancreatic tissue fragments in rat.
Topics: Animals; Diabetes Mellitus, Experimental; Glucagon; Immunohistochemistry; In Vitro Techniques; Islets of Langerhans; Pancreas; Radioimmunoassay; Rats; Tissue Distribution; Vasoactive Intestinal Peptide | 2000 |
Diabetogenic role of insulin's counterregulatory hormones in the isletectomized, diabetic goby.
Topics: Ammonia; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Disease Models, Animal; Fishes; Glucagon; Hydrocortisone; Hyperglycemia; Insulin; Islets of Langerhans; Kinetics; Nitrogen; Rats | 2000 |
Hepatic insulin expression improves glycemic control in type 1 diabetic rats.
Topics: Amino Acid Sequence; Animals; Blood Glucose; Consensus Sequence; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetic Ketoacidosis; Furin; Gene Transfer Techniques; Genetic Therapy; Glucagon; Hyperglycemia; Insulin; Islets of Langerhans; Liver; Liver Neoplasms, Experimental; Proinsulin; Protein Precursors; Rats; Rats, Nude; Subtilisins; Transfection | 2001 |
The roles of ATF3 in glucose homeostasis. A transgenic mouse model with liver dysfunction and defects in endocrine pancreas.
Topics: Activating Transcription Factor 3; Animals; Animals, Newborn; Cells, Cultured; Crosses, Genetic; Diabetes Mellitus, Experimental; Fructose-Bisphosphatase; Gene Expression Regulation; Glucagon; Gluconeogenesis; Glucose; Homeostasis; Humans; Immunohistochemistry; Insulin; Islets of Langerhans; Leucine Zippers; Liver; Male; Mice; Mice, Transgenic; Open Reading Frames; Oxidative Stress; Pancreatectomy; Phosphoenolpyruvate Carboxykinase (GTP); Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Reverse Transcriptase Polymerase Chain Reaction; Transcription Factors | 2001 |
Enhanced maturation of porcine neonatal pancreatic cell clusters with growth factors fails to improve transplantation outcome.
Topics: Animals; Animals, Newborn; Blood Glucose; C-Peptide; Cattle; Cell Culture Techniques; Culture Media; Diabetes Mellitus, Experimental; Gene Expression Regulation; Glucagon; Glucokinase; Glucose Transporter Type 2; Growth Substances; Humans; Insulin; Insulin-Like Growth Factor I; Islets of Langerhans; Islets of Langerhans Transplantation; Monosaccharide Transport Proteins; Niacinamide; Pancreas; Polymerase Chain Reaction; Recombinant Proteins; Somatostatin; Swine; Treatment Outcome | 2001 |
Attenuated processing of proglucagon and glucagon-like peptide-1 in carboxypeptidase E-deficient mice.
Topics: Animals; Carboxypeptidase H; Carboxypeptidases; Chromatography, Gel; Diabetes Mellitus, Experimental; Furin; Glucagon; Glucagon-Like Peptide 1; Intestinal Mucosa; Mice; Mice, Mutant Strains; Obesity; Pancreas; Peptide Fragments; Proglucagon; Protein Precursors; Subtilisins; Tissue Extracts | 2001 |
Peritoneal implantation of macroencapsulated porcine pancreatic islets in diabetic rats ameliorates severe hyperglycemia and prevents retraction and simplification of hippocampal dendrites.
Topics: Animals; Blood Glucose; Body Weight; C-Peptide; Capsules; Dendrites; Diabetes Mellitus, Experimental; Glucagon; Graft Survival; Hippocampus; Hyperglycemia; Insulin; Insulin Secretion; Islets of Langerhans Transplantation; Male; Nerve Degeneration; Peritoneum; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Swine; Treatment Outcome | 2001 |
Glucagon-like peptide-1 and exendin-4 stimulate beta-cell neogenesis in streptozotocin-treated newborn rats resulting in persistently improved glucose homeostasis at adult age.
Topics: Animals; Animals, Newborn; Apoptosis; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Exenatide; Female; Glucagon; Glucagon-Like Peptide 1; Homeostasis; Immunohistochemistry; Insulin; Islets of Langerhans; Organ Size; Peptide Fragments; Peptides; Protein Precursors; Rats; Rats, Wistar; Venoms | 2001 |
Effect of electrical field stimulation on insulin and glucagon secretion from the pancreas of normal and diabetic rats.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Atropine; Diabetes Mellitus, Experimental; Electric Stimulation; Glucagon; Insulin; Muscarinic Antagonists; Pancreas; Propranolol; Radioimmunoassay; Rats; Yohimbine | 2001 |
Reduction of incretin-like salivatin in saliva from patients with type 2 diabetes and in parotid glands of streptozotocin-diabetic BALB/c mice.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Eating; Enzyme-Linked Immunosorbent Assay; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Hypoglycemic Agents; Male; Mice; Mice, Inbred BALB C; Microscopy, Immunoelectron; Parotid Gland; Peptide Fragments; Peptides; Postprandial Period; Proline-Rich Protein Domains; Saliva; Salivary Proline-Rich Proteins | 2001 |
Decrease in beta-cell mass leads to impaired pulsatile insulin secretion, reduced postprandial hepatic insulin clearance, and relative hyperglucagonemia in the minipig.
Topics: Animals; B-Lymphocytes; Blood Glucose; Diabetes Mellitus, Experimental; Eating; Glucagon; Glucose; Insulin; Insulin Secretion; Kinetics; Liver; Postprandial Period; Pulsatile Flow; Swine; Swine, Miniature | 2001 |
Exercise down-regulates hepatic fatty acid synthase in streptozotocin-treated rats.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Down-Regulation; Fatty Acid Synthases; Glucagon; Insulin; Liver; Male; Motor Activity; Rats; Rats, Wistar; Reference Values; RNA, Messenger; Transcription Factors | 2001 |
Effect of GLP-1 treatment on GLUT2 and GLUT4 expression in type 1 and type 2 rat diabetic models.
Topics: Adipose Tissue; Animals; Blotting, Northern; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Gene Expression; Glucagon; Glucagon-Like Peptide 1; Glucose; Glucose Transporter Type 2; Glucose Transporter Type 4; Liver; Male; Monosaccharide Transport Proteins; Muscle Proteins; Muscle, Skeletal; Peptide Fragments; Protein Precursors; Rats; Rats, Wistar; RNA, Messenger | 2001 |
Differential impairment of glucagon responses to hypoglycemia, neuroglycopenia, arginine, and carbachol in alloxan-diabetic mice.
Topics: Animals; Arginine; Brain; Carbachol; Deoxyglucose; Diabetes Mellitus, Experimental; Female; Glucagon; Glucose; Hypoglycemia; Hypoglycemic Agents; Insulin; Mice; Mice, Inbred Strains | 2002 |
Selective up-regulation of system a transporter mRNA in diabetic liver.
Topics: Amino Acid Transport System A; Amino Acid Transport Systems, Neutral; Animals; Carrier Proteins; Diabetes Mellitus, Experimental; Glucagon; Hepatocytes; In Situ Hybridization; Liver; Male; Membrane Transport Proteins; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tissue Distribution; Transcriptional Activation; Up-Regulation | 2002 |
GLP-1 effect upon the GPI/IPG system in adipocytes and hepatocytes from diabetic rats.
Topics: Adipocytes; Animals; Blood Glucose; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Disease Models, Animal; Glucagon; Glucagon-Like Peptide 1; Glycosylphosphatidylinositols; Hepatocytes; Hypoglycemic Agents; Inositol Phosphates; Insulin; Liver; Male; Oligosaccharides; Pancreas; Peptide Fragments; Polysaccharides; Protein Precursors; Rats; Rats, Wistar | 2001 |
Evaluation of glycated glucagon-like peptide-1(7-36)amide in intestinal tissue of normal and diabetic animal models.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Disease Models, Animal; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glycosylation; Hydrocortisone; Intestine, Small; Mice; Mice, Obese; Organ Size; Peptide Fragments; Rats | 2002 |
The role of leucine-enkephalin on insulin and glucagon secretion from pancreatic tissue fragments of normal and diabetic rats.
Topics: Animals; Atropine; Diabetes Mellitus, Experimental; Enkephalin, Leucine; Glucagon; Insulin; Insulin Secretion; Naloxone; Pancreas; Rats; Yohimbine | 2001 |
Involvement of cellular calcium in exocrine pancreatic insufficiency during streptozotocin-induced diabetes mellitus.
Topics: Amylases; Animals; Calcium; Diabetes Mellitus, Experimental; Electric Stimulation; Exocrine Pancreatic Insufficiency; Female; Fluorescent Dyes; Fura-2; Glucagon; Insulin; Islets of Langerhans; Rats; Rats, Sprague-Dawley; Sincalide; Somatostatin | 2001 |
Potentiation and prolongation of the insulinotropic action of glucagon-like peptide 1 by methyl pyruvate or dimethyl ester of L-glutamic acid in a type 2 diabetes animal model.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Drug Synergism; Glucagon; Glucagon-Like Peptide 1; Glutamates; Injections, Intravenous; Insulin; Peptide Fragments; Protein Precursors; Pyruvates; Rats; Time Factors | 2001 |
Induction and acceleration of insulitis/diabetes in mice with a viral mimic (polyinosinic-polycytidylic acid) and an insulin self-peptide.
Topics: Alleles; Animals; CD4 Antigens; CD4-Positive T-Lymphocytes; CD8 Antigens; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Genotype; Glucagon; Immunohistochemistry; Insulin; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Peptides; Poly I-C; Time Factors | 2002 |
Beta cell expression of IGF-I leads to recovery from type 1 diabetes.
Topics: Animals; Apoptosis; Blood Glucose; Body Weight; Cell Division; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Drinking; Eating; Glucagon; Humans; Insulin; Insulin-Like Growth Factor I; Islets of Langerhans; Mice; Mice, Inbred C57BL; Mice, Transgenic | 2002 |
Mild streptozotocin diabetes in the Göttingen minipig. A novel model of moderate insulin deficiency and diabetes.
Topics: Animals; Arginine; Blood Glucose; Diabetes Mellitus, Experimental; Disease Models, Animal; Fasting; Food; Glucagon; Glucose Tolerance Test; Insulin; Insulin Secretion; Islets of Langerhans; Male; Niacinamide; Streptozocin; Swine, Miniature; Time Factors | 2002 |
Effects of recurrent hyperinsulinemia with and without hypoglycemia on counterregulation in diabetic rats.
Topics: Adrenocorticotropic Hormone; Animals; Blood Glucose; Corticosterone; Diabetes Mellitus, Experimental; Epinephrine; Glucagon; Glucose; Glucose Clamp Technique; Homeostasis; Hyperglycemia; Hyperinsulinism; Hypoglycemia; Insulin; Male; Norepinephrine; Pancreas; Proglucagon; Protein Precursors; Rats; Rats, Sprague-Dawley; Recurrence; RNA, Messenger; Somatostatin | 2002 |
Diabetes impairs hypothalamo-pituitary-adrenal (HPA) responses to hypoglycemia, and insulin treatment normalizes HPA but not epinephrine responses.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Animals; Body Weight; Corticosterone; Corticotropin-Releasing Hormone; Diabetes Mellitus, Experimental; Epinephrine; Gene Expression; Glucagon; Glucose Clamp Technique; Hypoglycemia; Hypothalamo-Hypophyseal System; Hypothalamus; Insulin; Male; Norepinephrine; Pituitary Gland; Pro-Opiomelanocortin; Rats; Rats, Sprague-Dawley; Receptors, Glucocorticoid; RNA, Messenger | 2002 |
The essential role of glucagon in the pathogenesis of diabetes mellitus.
Topics: Alanine; Animals; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Experimental; Dogs; Glucagon; Glucose; Growth Hormone-Releasing Hormone; Humans; Hyperglycemia; Insulin; Insulin Secretion; Islets of Langerhans; Liver; Pancreatectomy | 1975 |
Effects of intrahepatic transplantation of pancreatic islets on hepatic metabolism in the rat.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Female; Glucagon; Gluconeogenesis; Glucose; Hyperglycemia; Insulin; Insulin Secretion; Islets of Langerhans; Islets of Langerhans Transplantation; Liver; Male; Rats; Transplantation, Homologous; Urea | 1978 |
Effect of glucagon on calcium binding by rat liver plasma membranes.
Topics: Adenylyl Cyclases; Animals; Calcium; Cell Membrane; Diabetes Mellitus, Experimental; Egtazic Acid; Fluorides; Glucagon; Kinetics; Liver; Male; Rats | 1978 |
Efficacy of combined insulin and somatostatin infusion for the treatment of experimental diabetic ketoacidosis.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Ketoacidosis; Fatty Acids, Nonesterified; Glucagon; Growth Hormone; Hydroxybutyrates; Insulin; Male; Rats; Somatostatin | 1979 |
Insulin and glucose as modulators of the amino acid-induced glucagon release in the isolated pancreas of alloxan and streptozotocin diabetic rats.
Topics: Amino Acids; Animals; Diabetes Mellitus; Diabetes Mellitus, Experimental; Glucagon; Glucose; In Vitro Techniques; Insulin; Islets of Langerhans; Male; Perfusion; Rats; Streptozocin | 1975 |
Treatment with glucagon-binding antibodies alters the intestinal response to starvation in the rat.
Topics: Animals; Antibodies; Biological Transport; Diabetes Mellitus; Diabetes Mellitus, Experimental; Glucagon; Intestinal Mucosa; Male; Rats; Starvation; Streptozocin | 1975 |
Regulation of glucagon secretion of the diabetic pancreas in vitro [proceedings].
Topics: Animals; Diabetes Mellitus; Diabetes Mellitus, Experimental; Glucagon; Glucose; Insulin; Islets of Langerhans; Rats; Streptozocin | 1976 |
Glucose and ATP levels in pancreatic islet tissue of normal and diabetic rats.
Topics: Adenosine Triphosphate; Animals; Diabetes Mellitus; Diabetes Mellitus, Experimental; Glucagon; Glucose; Insulin; Islets of Langerhans; Male; Perfusion; Rats; Streptozocin; Sucrose; Urea | 1976 |
Oscillatory changes in muscle lipoprotein lipase activity of fed and starved rats.
Topics: Animals; Blood Glucose; Circadian Rhythm; Diabetes Mellitus, Experimental; Diaphragm; Glucagon; Lipoprotein Lipase; Male; Muscles; Myocardium; Rats; Starvation; Streptozocin | 1977 |
Glucagon and insulin relationships in genetically diabetic (db/db) and in streptozotocin-induced diabetic mice.
Topics: Aging; Animals; Diabetes Mellitus; Diabetes Mellitus, Experimental; Glucagon; Insulin; Mice; Streptozocin | 1978 |
Immunohistochemical changes of somatostatin cells in the pancreatic islets of rats after streptozotocin administration.
Topics: Animals; Diabetes Mellitus, Experimental; Glucagon; Immunoenzyme Techniques; Insulin; Islets of Langerhans; Male; Rats; Somatostatin; Streptozocin | 1978 |
[Insulin, glucagon binding and adenylate cyclase activity of liver plasma membranes in streptozotocin-diabetic rats].
Topics: Adenylyl Cyclases; Animals; Cell Membrane; Diabetes Mellitus, Experimental; Glucagon; Liver; Rats; Receptor, Insulin; Streptozocin | 1978 |
Changes in somatostatin concentration in pancreas and other tissues of streptozotocin diabetic rats.
Topics: Alloxan; Animals; Diabetes Mellitus, Experimental; Fluorescent Antibody Technique; Gastric Mucosa; Glucagon; Hypothalamus; Insulin; Islets of Langerhans; Male; Pancreas; Rats; Somatostatin; Streptozocin | 1978 |
Effect of in vivo and in vitro application of glucagon, insulin and epinephrine on Ca++-transport properties of liver mitochondria.
Topics: Animals; Biological Transport, Active; Calcium; Cycloheximide; Diabetes Mellitus, Experimental; Epinephrine; Female; Glucagon; In Vitro Techniques; Insulin; Mitochondria, Liver; Rats; Starvation; Streptozocin | 1979 |
Studies on gluconeogenesis, protein synthesis and cyclic AMP levels in isolated hepatocytes from alloxan diabetic rats.
Topics: Animals; Cyclic AMP; Diabetes Mellitus, Experimental; Endoplasmic Reticulum; Fructose; Glucagon; Gluconeogenesis; Histocytochemistry; Isoleucine; Lactates; Lipid Metabolism; Liver; Liver Glycogen; Male; Phenylalanine; Protein Biosynthesis; Rats; Theophylline; Vacuoles; Valine | 1975 |
Adenosine 3',5'cyclic monophosphate in adipose tissue of diabetic rats.
Topics: Adipose Tissue; Animals; Blood Glucose; Cyclic AMP; Diabetes Mellitus; Diabetes Mellitus, Experimental; Epinephrine; Fatty Acids, Nonesterified; Glucagon; Immune Sera; Kinetics; Male; Rats; Theophylline | 1976 |
Altered lethality of murine toxin from Yersinia pestis under various metabolic conditions.
Topics: Animals; Bacterial Toxins; Blood Glucose; Body Temperature Regulation; Bucladesine; Cortisone; Diabetes Mellitus, Experimental; Diet; Epinephrine; Fasting; Fatty Acids, Nonesterified; Female; Glucagon; Lipid Metabolism; Male; Mice; Mice, Inbred C3H; Temperature; Yersinia pestis | 1977 |
Effect of experimental diabetes and glucagon on cAMP-dependent protein kinase in rat liver.
Topics: Animals; Cyclic AMP; Diabetes Mellitus, Experimental; Enzyme Activation; Glucagon; Insulin; Liver; Male; Protein Kinases; Rats | 1977 |
Hormonal regulation of hepatic amino acid transport.
Topics: Amino Acids; Aminoisobutyric Acids; Animals; Biological Transport; Cyclic AMP; Diabetes Mellitus, Experimental; Glucagon; Insulin; Leucine; Liver; Perfusion; Rats; Sodium | 1977 |
Regulation in vitro and in vivo of adenosine 3':5'-monophosphate-dependent inactivation of rat-liver pyruvate kinase type L.
Topics: Adenosine Triphosphate; Amino Acids; Animals; Cyclic AMP; Diabetes Mellitus, Experimental; Fructosediphosphates; Glucagon; In Vitro Techniques; Isoenzymes; Kinetics; Liver; Magnesium; Pyruvate Kinase; Rats | 1977 |
Biological properties of islets-activating protein (IAP) purified from the culture medium of Bordetella pertussis.
Topics: Animals; Bacterial Proteins; Blood Glucose; Bordetella pertussis; Culture Media; Diabetes Mellitus, Experimental; Epinephrine; Glucagon; Glucose; Histamine; Insulin; Insulin Secretion; Leukocytosis; Mice; Rats | 1978 |
Hormonal control of amino acid transport in the liver of rats exposed to whole-body gamma irradiation.
Topics: Amino Acids; Aminoisobutyric Acids; Animals; Biological Transport; Corticosterone; Cyclic AMP; Diabetes Mellitus, Experimental; Gamma Rays; Glucagon; Growth Hormone; Insulin; Liver; Male; Rats | 1978 |
Glucagon binding and adenylate cyclase activity in liver membranes from untreated and insulin-treated diabetic rats.
Topics: Adenylyl Cyclases; Animals; Body Weight; Cell Membrane; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Glucagon; Insulin; Liver; Proteins; Rats; Receptors, Cell Surface | 1978 |
A hundred years of the hepatotrophic controversy.
Topics: Animals; Cell Division; Cyclic AMP; Diabetes Mellitus, Experimental; Disease Models, Animal; Dogs; Glucagon; Hepatic Artery; Insulin; Liver; Liver Circulation; Liver Regeneration; Pancreatectomy; Portacaval Shunt, Surgical; Portal Vein | 1977 |
Decreased glucagon receptors in diabetic rat hepatocytes. Evidence for regulation of glucagon receptors by hyperglucagonemia.
Topics: Animals; Blood Glucose; Cyclic AMP; Diabetes Mellitus, Experimental; Glucagon; In Vitro Techniques; Insulin; Liver; Male; Rats; Receptors, Drug | 1978 |
Virus-induced diabetes in mice: a quantitative evaluation of islet cell population by immunofluorescence technique.
Topics: Animals; Diabetes Mellitus, Experimental; Encephalomyocarditis virus; Enterovirus Infections; Fluorescent Antibody Technique; Glucagon; Insulin; Islets of Langerhans; Male; Mice; Pancreatic Polypeptide; Somatostatin | 1978 |
The influence of obesity and diabetes in the monkey on insulin and glucagon binding to liver membranes.
Topics: Animals; Cell Membrane; Diabetes Mellitus; Diabetes Mellitus, Experimental; Glucagon; Haplorhini; Hypothalamus; Insulin; Kinetics; Liver; Macaca mulatta; Male; Obesity; Receptor, Insulin; Receptors, Cell Surface | 1979 |
Biochemical and ultrastructural changes in A and B cells of the islets of Langerhans of mice infected with EMC virus.
Topics: Adenylyl Cyclases; Animals; Diabetes Mellitus, Experimental; Encephalomyocarditis virus; Enterovirus Infections; Fluorides; Glucagon; Insulin; Islets of Langerhans; Male; Mice; Pancreas | 1979 |
Participation of pancreatic hormones in the regulation of UDPG-pyrophosphorylase activity in the sublingual and submandibular salivary glands and liver in the rat.
Topics: Animals; Dactinomycin; Diabetes Mellitus, Experimental; Glucagon; Insulin; Liver; Male; Nucleotidyltransferases; Pancreatic Hormones; Puromycin; Rats; Sublingual Gland; Submandibular Gland; Theophylline; UTP-Glucose-1-Phosphate Uridylyltransferase | 1978 |
Glucose and 3-O-methylglucose protection against alloxan poisoning of pancreatic alpha and beta cells.
Topics: Alloxan; Animals; Diabetes Mellitus, Experimental; Glucagon; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Male; Methylglucosides; Methylglycosides; Pancreas; Rats | 1977 |
Morphometric quantitation of the pancreatic insulin-, glucagon-, and somatostatin-positive cell populations in normal and alloxan-diabetic rats.
Topics: Animals; Blood Glucose; Cell Count; Diabetes Mellitus, Experimental; Glucagon; Glycosuria; Insulin; Islets of Langerhans; Male; Organ Size; Rats; Somatostatin | 1977 |
Endocrine cells in oxyntic mucosa of a dog 5 years after pancreatectomy.
Topics: Animals; Diabetes Mellitus, Experimental; Dogs; Fluorescent Antibody Technique; Gastric Mucosa; Gastrointestinal Hormones; Glucagon; Pancreatectomy | 1977 |
Syngeneic transplantation of fetal rat pancreas. III. Effect of insulin treatment on the growth and differentiation of the pancreatic implants after reversal of diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Glucagon; Glucose; Insulin; Islets of Langerhans; Male; Pancreas; Pancreas Transplantation; Rats; Rats, Inbred F344; Transplantation, Isogeneic | 1979 |
Effect of diet limitation on development of diabetes in non-hyperphagic prediabetic Chinese hamsters.
Topics: Animals; Blood Glucose; Cricetinae; Cricetulus; Diabetes Mellitus, Experimental; Diet, Diabetic; Female; Glucagon; Insulin; Islets of Langerhans; Male; Pancreas; Prediabetic State | 1979 |
Ultrastructural and morphometric studies of delta cells in pancreatic islets from C57BL/Ks diabetes mice.
Topics: Animals; Diabetes Mellitus, Experimental; Female; Glucagon; Histocytochemistry; Islets of Langerhans; Mice; Mice, Inbred Strains; Pancreatic Polypeptide; Somatostatin | 1979 |
A method for the estimation of esterase synthesis and degradation and its application to evaluate the influence of insulin and glucagon.
Topics: Animals; Diabetes Mellitus, Experimental; Esterases; Glucagon; Insulin; Kinetics; Liver; Male; Mathematics; Microsomes, Liver; Nitrophenols; Organophosphorus Compounds; Protein Binding; Rats | 1979 |
Endocrine pancreatic cells of postnatal "diabetes" (db) mice in cell culture.
Topics: Animals; Cell Differentiation; Culture Techniques; Cytoplasmic Granules; Diabetes Mellitus, Experimental; Epinephrine; Glucagon; Insulin; Islets of Langerhans; Mice; Mice, Inbred Strains; Organoids; Tolbutamide | 1979 |
Streptozotocin diabetes: a glucoreceptor dysfunction affecting D cells as well as B and A cells.
Topics: Animals; Arginine; Calcium; Diabetes Mellitus, Experimental; Dogs; Glucagon; Glucose; Insulin; Isoproterenol; Male; Pancreas; Somatostatin | 1979 |
Perfused liver carnitine palmitoyl-transferase activity and ketogenesis in streptozotocin treated and genetic hyperinsulinemic rats. Effect of glucagon.
Topics: Acyltransferases; Animals; Blood Glucose; Carnitine O-Palmitoyltransferase; Diabetes Mellitus, Experimental; Glucagon; Hyperinsulinism; In Vitro Techniques; Insulin; Ketone Bodies; Mitochondria, Liver; Obesity; Perfusion; Rats | 1979 |
Insulin-releasing activity and successful transplantation of pancreatic islets preserved by tissue culture.
Topics: Animals; Culture Techniques; Diabetes Mellitus, Experimental; Glucagon; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Islets of Langerhans Transplantation; Male; Organ Preservation; Portal Vein; Rats; Tolbutamide; Transplantation, Homologous | 1978 |
[The immunofluorescence-microscopical evidence of insulin and glucagon in transplantated isolated Langerhans' islets in diabetic rats and dogs (author's transl)].
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Fluorescent Antibody Technique; Glucagon; Insulin; Islets of Langerhans; Islets of Langerhans Transplantation; Rats; Transplantation, Homologous | 1977 |
Physiologic aspects of intrasplenic autotransplantation of pancreatic fragments in the dog after 24 hours of cold storage.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Disease Models, Animal; Dogs; Female; Glucagon; Insulin; Islets of Langerhans Transplantation; Male; Pancreatectomy; Spleen; Time Factors; Tissue Preservation; Transplantation, Autologous | 1978 |
Amino acid patterns in the blood of alloxan diabetic rabbits: response to glucagon [proceedings].
Topics: Amino Acids; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucagon; Male; Rabbits | 1979 |
Treatment of streptozotocin-diabetic dogs with a long-acting somatostatin analog.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Glucagon; Glucose Tolerance Test; Insulin; Kinetics; Methylglucosides; Somatostatin | 1979 |
Increased somatostatin release from pancreases of alloxan diabetic rats perfused in vitro.
Topics: Animals; Arginine; Diabetes Mellitus, Experimental; Glucagon; In Vitro Techniques; Insulin; Male; Pancreas; Rats; Somatostatin | 1979 |
Effects of orotate administration on the normal rat kidney: similarity to changes observed in diabetes mellitus.
Topics: Animals; Basement Membrane; Diabetes Mellitus, Experimental; DNA; Glucagon; Kidney Cortex; Kidney Glomerulus; Male; Orotic Acid; Rats; RNA; Uridine Triphosphate | 1979 |
Enhancement of mitochondrial carnitine and carnitine acylcarnitine translocase-mediated transport of fatty acids into liver mitochondria under ketogenic conditions.
Topics: Acyltransferases; Animals; Animals, Newborn; Biological Transport, Active; Carnitine; Carnitine Acyltransferases; Diabetes Mellitus, Experimental; Fasting; Fatty Acids; Female; Glucagon; Ketone Bodies; Kinetics; Male; Mitochondria, Liver; Rats; Sex Factors; Structure-Activity Relationship | 1979 |
Glucose production by the perfused liver of the spiny mouse (Acomys cahirinus): sensitivity to glucagon and insulin.
Topics: Animals; Body Weight; Diabetes Mellitus, Experimental; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Glucagon; Glucose; Insulin; Lipids; Liver; Male; Mice | 1979 |
The influence of endogenous glucagon release on hyperglycemic responses to catecholamines in normal fed and diabetic rats.
Topics: Animals; Blood Glucose; Catecholamines; Diabetes Mellitus, Experimental; Epinephrine; Glucagon; Insulin; Isoproterenol; Male; Rats; Somatostatin; Time Factors | 1979 |
Induction of glucagon synthesis in diabetic CBA mice bearing mammary aplastic carcinomas.
Topics: Adaptation, Physiological; Animals; Diabetes Mellitus, Experimental; Glucagon; Male; Mammary Neoplasms, Experimental; Mice; Mice, Inbred CBA | 1979 |
Response of extrapancreatic glucagon to arginine in dogs.
Topics: Animals; Arginine; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Gastrectomy; Glucagon; Insulin; Pancreatectomy | 1979 |
Synthesis and biological activity of glycosylated analogs of somatostatin.
Topics: Amino Acids; Animals; Diabetes Mellitus, Experimental; Glucagon; Growth Hormone; Insulin; Male; Morphine; Pituitary Gland, Anterior; Rats; Somatostatin; Structure-Activity Relationship | 1979 |
Plasma glucagon responses to insulin-induced hypoglycaemia and arginine in normal and alloxan diabetic rats.
Topics: Alloxan; Animals; Arginine; Blood Glucose; Diabetes Mellitus, Experimental; Glucagon; Hypoglycemia; Insulin; Male; Rats | 1979 |
Effect of insulin treatment upon response of extrapancreatic glucagon to arginine.
Topics: Alloxan; Animals; Arginine; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Glucagon; Immunoassay; Insulin; Pancreas; Pancreatectomy; Time Factors | 1979 |
Effect of glucagon on glomerulopressin production in diabetic dogs.
Topics: Animals; Diabetes Mellitus, Experimental; Dogs; Female; Glomerular Filtration Rate; Glucagon; Kidney Glomerulus; Male; Pancreatectomy; Vasopressins; Water-Electrolyte Balance | 1978 |
Streptozotocin-induced diabetes in the Chinese hamster. Biochemical and endocrine disorders.
Topics: Acetylglucosaminidase; Animals; Blood Glucose; Body Weight; Cricetinae; Cricetulus; Diabetes Mellitus, Experimental; Galactosidases; Glucagon; Gluconeogenesis; Glycolysis; Insulin; Isoenzymes; Kidney; L-Lactate Dehydrogenase; Liver; Male; Myocardium; Organ Size | 1977 |
Insulin and glucagon as determinants of body weight set point and microregulation in rats.
Topics: Animals; Body Weight; Diabetes Mellitus, Experimental; Drinking Behavior; Feeding Behavior; Glucagon; Homeostasis; Insulin; Insulin, Long-Acting; Male; Motor Activity; Protamines; Rats; Somatostatin; Zinc | 1978 |
Prolonged suppression of pituitary and pancreatic hormone release by a somatostatin analog.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Glucagon; Growth Hormone; Pancreas; Pituitary Gland; Rats; Somatostatin; Time Factors | 1978 |
Ketone body turnover and net hepatic ketone production in fasted and diabetic dogs.
Topics: Acetoacetates; Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Fasting; Fatty Acids, Nonesterified; Female; Glucagon; Hydroxybutyrates; Ketone Bodies; Liver; Male; Regional Blood Flow | 1978 |
Effect of glucagon on glucose production during insulin deficiency in the dog.
Topics: Alanine; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Female; Glucagon; Gluconeogenesis; Hyperglycemia; Insulin; Lactates; Male; Somatostatin; Time Factors | 1978 |
Somatotrophic diabetes: insulin release responses to arginine and glucagon in dogs.
Topics: Animals; Arginine; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Food; Glucagon; Glucose; Growth Hormone; Insulin; Male; Pancreas | 1978 |
Effect of free fatty acids and amino acids on glucagon and insulin secretions in normal and diabetic ducks.
Topics: Animals; Arginine; Diabetes Mellitus, Experimental; Ducks; Glucagon; Insulin; Male; Oleic Acids; Pancreatectomy | 1978 |
Somatostatin analogs as glucagon suppressants in diabetes.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Glucagon; Somatostatin; Triglycerides | 1978 |
The effect of potassium and valinomycin on insulin and glucagon secretion in the perfused rat pancreas.
Topics: Animals; Arginine; Diabetes Mellitus, Experimental; Ethanol; Glucagon; Insulin; Insulin Secretion; Kinetics; Pancreas; Perfusion; Potassium; Rats; Valinomycin | 1978 |
The response of plasma somatostatin-like immunoreactivity to nutrients in normal and alloxan diabetic dogs.
Topics: Animals; Caseins; Diabetes Mellitus, Experimental; Dietary Proteins; Dogs; Eating; Glucagon; Glucose; Somatostatin | 1978 |
Demonstration of gastric glucagon hypersecretion in insulin-deprived alloxan-diabetic dogs.
Topics: Animals; Arginine; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Gastric Mucosa; Glucagon; Infusions, Parenteral; Insulin; Pancreas | 1977 |
Somatostatin in the pancreas, stomach and hypothalamus of the diabetic Chinese hamster.
Topics: Animals; Cricetinae; Cricetulus; Diabetes Mellitus, Experimental; Gastric Mucosa; Glucagon; Histocytochemistry; Hypothalamus; Insulin; Pancreas; Somatostatin | 1977 |
Comparison of highly inbred diabetic and nondiabetic lines in the Upjohn colony of Chinese hamsters.
Topics: Acetylglucosaminidase; Adipose Tissue; Animals; Blood Glucose; Body Weight; Cricetinae; Cricetulus; Diabetes Mellitus, Experimental; Female; Glucagon; Glycoside Hydrolases; Glycosuria; Humans; Inbreeding; Insulin; Kidney; Liver; Male; Michigan; Phenotype | 1977 |
Binding and biologic activity of glucagon in liver cell membranes of chronically hyperglucagonemic rats.
Topics: Adenylyl Cyclases; Animals; Cell Membrane; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Female; Glucagon; Insulin; Kinetics; Liver; Rats | 1977 |
[Studies on the relationship between endocrine and exocrine pancreatic functions. Part II. Exocrine pancreatic function and insulin and glucagon levels in streptozotocin induced diabetic rats (author's transl)].
Topics: Amylases; Animals; Diabetes Mellitus, Experimental; Glucagon; Insulin; Male; Pancreas; Pancreatic Juice; Rats | 1977 |
Extrapancreatic glucagon in the dog.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Glucagon; Glucose; Insulin; Liver; Pancreas; Somatostatin; Stomach | 1976 |
Gastric glucagon secretion.
Topics: Animals; Diabetes Mellitus, Experimental; Dogs; Gastric Mucosa; Glucagon; Insulin; Pancreas | 1976 |
Effects of glucagon and insulin on lipolysis and ketogenesis in sheep.
Topics: Acetoacetates; Animals; Diabetes Mellitus, Experimental; Female; Glucagon; Hydroxybutyrates; Insulin; Lipid Metabolism; Liver; Sheep | 1976 |
Role of carnitine in hepatic ketogenesis.
Topics: Animals; Carnitine; Diabetes Mellitus, Experimental; Glucagon; Insulin; Ketones; Liver; Male; Oleic Acids; Rats | 1975 |
Glucagon: role in the hyperglycemia of diabetes mellitus.
Topics: Animals; Arginine; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimental; Dogs; Glucagon; Growth Hormone-Releasing Hormone; Hyperglycemia; Insulin; Oligopeptides; Pancreatectomy | 1975 |
Heterogeneity of plasma glucagon immunoreactivity in normal, depancreatized, and alloxan-diabetic dogs.
Topics: Animals; Arginine; Chromatography, Gel; Diabetes Mellitus, Experimental; Dogs; Glucagon; Insulin; Iodine Radioisotopes; Molecular Weight; Pancreas; Pancreatectomy; Phlorhizin; Somatostatin | 1975 |
Effect of glucagon on plasma alanine and glutamine metabolism and hepatic gluconeogenesis in sheep.
Topics: Alanine; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Female; Glucagon; Gluconeogenesis; Glutamates; Glutamine; Liver; Models, Biological; Sheep; Stimulation, Chemical | 1975 |
The role of glucagon in the pathogenesis of the endogenous hyperglycemia of diabetes mellitus.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diazoxide; Dogs; Glucagon; Hyperglycemia; Pancreas; Pancreatectomy; Somatostatin | 1975 |
Portal hepatotrophic factors, diabetes mellitus and acute liver atrophy, hypertrophy and regeneration.
Topics: Animals; Atrophy; Autoradiography; Diabetes Mellitus, Experimental; DNA; Dogs; Glucagon; Hepatectomy; Hepatomegaly; Insulin; Liver; Liver Diseases; Liver Regeneration; Pancreatectomy; Portal System; Thymidine; Tritium | 1975 |
Effects of glucagon and insulin on net hepatic metabolism of glucose precursors in sheep.
Topics: Amino Acids; Animals; Diabetes Mellitus, Experimental; Female; Glucagon; Glucose; Glycerol; Insulin; Lactates; Liver; Pyruvates; Sheep | 1975 |
[The influence of glucagon on post-heparin plasma lipolytic activity in normal rats and in rats with diabetes induced by alloxan injection].
Topics: Animals; Diabetes Mellitus, Experimental; Fatty Acids, Nonesterified; Glucagon; Heparin; Insulin; Insulin Secretion; Lipoprotein Lipase; Male; Rats; Stimulation, Chemical; Time Factors | 1976 |
Enzymic and metabolic anomalies in islets of diabetic rats: relationship to B cell mass.
Topics: 3-O-Methylglucose; Animals; Biological Transport; Blood Glucose; Diabetes Mellitus, Experimental; Glucagon; Glucose-6-Phosphatase; Glutamate Dehydrogenase; Glycerolphosphate Dehydrogenase; In Vitro Techniques; Insulin; Islets of Langerhans; Kinetics; Liver; Methylglucosides; Microsomes; Microsomes, Liver; Rats; Reference Values | 1992 |
Effects of androgen treatment on adenylate cyclase system in rat hepatic membranes.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Androgens; Animals; Binding, Competitive; Blood Glucose; Catecholamines; Cells, Cultured; Diabetes Mellitus, Experimental; Female; Glucagon; Isoproterenol; Kinetics; Liver; Membranes; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Stimulation, Chemical; Testosterone | 1992 |
The antidiabetic beta 3-adrenoceptor agonist BRL 26830A works by release of endogenous insulin.
Topics: Adrenergic beta-Agonists; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Ethanolamines; Female; Glucagon; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Mice; Mice, Inbred ICR; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta | 1992 |
Reversal of diabetes by the induction of islet cell neogenesis.
Topics: Analysis of Variance; Animals; Blood Glucose; Cricetinae; Diabetes Mellitus, Experimental; Female; Glucagon; Insulin; Islets of Langerhans; Mesocricetus; Pancreatic Extracts; Proteins; Regeneration; Somatostatin; Tissue Extracts | 1992 |
Glucagon, insulin and somatostatin secretion in response to sympathetic neural activation in streptozotocin-induced diabetic rats. A study with the isolated perfused rat pancreas in vitro.
Topics: Animals; Animals, Newborn; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Disease Models, Animal; Electric Stimulation; Glucagon; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Neurons; Perfusion; Rats; Rats, Wistar; Somatostatin; Splanchnic Nerves; Streptozocin; Sympathetic Nervous System | 1992 |
[State of the pancreatic insular apparatus in experimental diabetes mellitus with varying degrees of severity in the rat].
Topics: Animals; Diabetes Mellitus, Experimental; Female; Glucagon; Insulin; Islets of Langerhans; Rats; Rats, Wistar; Somatostatin | 1992 |
[Studies on stable control of blood sugar by continuous administration of insulin through isolated intestinal loop].
Topics: Animals; Aprotinin; Benzamidines; Blood Glucose; Catheters, Indwelling; Diabetes Mellitus, Experimental; Dogs; Drug Therapy, Combination; Glucagon; Guanidines; Insulin; Jejunum; Streptozocin | 1992 |
The effect of vanadate upon the expression of phenylalanine hydroxylase in streptozotocin-diabetic rat liver.
Topics: Animals; Blotting, Northern; Blotting, Western; Cells, Cultured; Diabetes Mellitus, Experimental; Glucagon; Hydroxylation; Liver; Male; Phenylalanine Hydroxylase; Phosphorylation; Rats; Rats, Wistar; RNA; Streptozocin; Vanadates | 1992 |
Effects of acute and chronic counterregulatory hormone infusions on glucose tolerance and insulin sensitivity in diabetic dogs.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Epinephrine; Fatty Acids, Nonesterified; Glucagon; Glucose Tolerance Test; Hydrocortisone; Infusions, Intravenous; Insulin; Insulin Infusion Systems; Kinetics | 1992 |
Evidence that GLUT-2 mRNA and protein concentrations are decreased by hyperinsulinaemia and increased by hyperglycaemia in liver of diabetic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Gene Expression; Glucagon; Glucokinase; Hyperglycemia; Insulin; Liver; Male; Monosaccharide Transport Proteins; Phosphoenolpyruvate Carboxykinase (GTP); Rats; Rats, Wistar; RNA, Messenger | 1992 |
[Clinical and experimental study of semen Persical decoction for purgation with addition in type II diabetes mellitus].
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Drugs, Chinese Herbal; Female; Glucagon; Humans; Insulin; Islets of Langerhans; Male; Mice; Middle Aged; Rats; Rats, Inbred Strains | 1992 |
Markedly reduced beta-cell function does not result in insulin resistance in islet autografted dogs.
Topics: Animals; Arginine; Blood Glucose; Diabetes Mellitus, Experimental; Disease Models, Animal; Dogs; Female; Glucagon; Insulin; Insulin Resistance; Islets of Langerhans; Islets of Langerhans Transplantation; Male; Pancreatectomy; Transplantation, Autologous | 1992 |
P2y purinoceptor responses of beta cells and vascular bed are preserved in diabetic rat pancreas.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucagon; Glycosuria; In Vitro Techniques; Insulin; Islets of Langerhans; Male; Pancreas; Rats; Rats, Inbred Strains; Receptors, Purinergic | 1992 |
Adrenodemedullation does not impair the beneficial effect of physical training in streptozotocin-diabetic rats.
Topics: Adrenal Medulla; Adrenalectomy; Analysis of Variance; Animals; Blood Glucose; Body Weight; Corticosterone; Diabetes Mellitus, Experimental; Epinephrine; Glucagon; Glycosuria; Insulin; Isocitrate Dehydrogenase; Male; Muscles; Norepinephrine; Physical Exertion; Physical Fitness; Rats; Rats, Inbred Strains | 1992 |
Metabolic effect of pancreaticoduodenal transplantation in diabetic rats.
Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Duodenum; Female; Glucagon; Glycosuria; Hyperinsulinism; Insulin; Male; Pancreas Transplantation; Rats; Rats, Inbred Strains | 1992 |
Suppressive effect of vasopressin on ketosis in diabetic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Coma; Fatty Acids, Nonesterified; Glucagon; Glycerol; Insulin; Ketone Bodies; Ketosis; Male; Rats; Rats, Inbred Strains; Vasopressins | 1992 |
[Protective effect of indomethacin on alloxan-induced diabetes in rat].
Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucagon; Indomethacin; Insulin; Islets of Langerhans; Rats; Rats, Inbred Strains | 1992 |
Diabetes alters the responses of glucagon secreting cells and vascular bed to isoprenaline and forskolin in vitro in rat pancreas.
Topics: Adenylyl Cyclases; Animals; Blood Flow Velocity; Colforsin; Diabetes Mellitus, Experimental; Glucagon; Insulin; Isoproterenol; Kinetics; Male; Pancreas; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Vasodilation | 1991 |
Changes in plasma insulin and glucagon concentrations and hepatic enzyme activities in diabetic voles treated with monosodium aspartate.
Topics: Animals; Arvicolinae; Aspartic Acid; Blood Glucose; Diabetes Mellitus, Experimental; Disease Models, Animal; Fructose-Bisphosphatase; Glucagon; Glucokinase; Insulin; Liver | 1991 |
Altered transcriptional regulation of phosphoenolpyruvate carboxykinase in rats following endotoxin treatment.
Topics: Animals; Cyclic AMP; Diabetes Mellitus, Experimental; Endotoxins; Gene Expression; Glucagon; Insulin; Interleukin-6; Male; Phosphoenolpyruvate Carboxykinase (GTP); Rats; Rats, Inbred Strains; Transcription, Genetic | 1991 |
Hormone-stimulated glucose production from glycogen in hepatocytes from streptozotocin diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Enzyme Activation; Glucagon; Glucose; Glucose-6-Phosphatase; Glycogen; Hormones; Liver; Microsomes; Phenylephrine; Phosphorylases; Reference Values; Vasopressins | 1991 |
Diabetes mellitus and glucagon alter ouabain-sensitive Na(+)-K(+)-ATPase in rat small intestine.
Topics: Animals; Cell Membrane; Cycloheximide; Diabetes Mellitus, Experimental; Evoked Potentials; Glucagon; Glucose; Ileum; In Vitro Techniques; Insulin; Intestinal Mucosa; Kinetics; Male; Muscle, Smooth; Ouabain; Rats; Rats, Inbred Lew; Reference Values; Sodium-Potassium-Exchanging ATPase | 1991 |
Inherent beta-cell dysfunction induced by transgenic expression of allogeneic major histocompatibility complex class I antigen in islet cells.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Female; Gene Expression; Glucagon; H-2 Antigens; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Isoantigens; Male; Mice; Mice, Inbred C57BL; Mice, Nude; Mice, Transgenic | 1991 |
Morphological analysis of selective destruction of pancreatic beta-cells by cytotoxic T lymphocytes in NOD mice.
Topics: Animals; Cells, Cultured; Cytotoxicity, Immunologic; Diabetes Mellitus, Experimental; Female; Glucagon; Immunoenzyme Techniques; Immunohistochemistry; Insulin; Islets of Langerhans; Killer Cells, Natural; Mice; Mice, Inbred C3H; Mice, Mutant Strains; Microscopy, Electron; Somatostatin; T-Lymphocytes, Cytotoxic | 1991 |
Immunohistochemical, ultrastructural, and hormonal studies on the endocrine pancreas of voles (Microtus arvalis) with monosodium aspartate-induced diabetes.
Topics: Animals; Arvicolinae; Aspartic Acid; Blood Glucose; Cytoplasmic Granules; Diabetes Mellitus, Experimental; Female; Glucagon; Hyperplasia; Hypertrophy; Immunohistochemistry; Insulin; Islets of Langerhans; Male; Microscopy, Electron; Rodent Diseases; Somatostatin | 1991 |
Effects of a beta 3-adrenoceptor agonist, BRL 26830A, on insulin and glucagon release in mice.
Topics: Adrenergic beta-Agonists; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Ethanolamines; Female; Glucagon; Insulin; Islets of Langerhans; Mice; Mice, Inbred ICR; Receptors, Adrenergic, beta; Streptozocin; Time Factors | 1991 |
The patterns of beta-cell regeneration in untreated diabetic and insulin-treated diabetic Syrian hamsters after streptozotocin treatment.
Topics: Animals; Antibodies; Autoradiography; Cell Count; Cell Differentiation; Cell Division; Cricetinae; Diabetes Mellitus, Experimental; DNA; Glucagon; Immunohistochemistry; Insulin; Islets of Langerhans; Male; Mesocricetus; Mice; Regeneration; Somatostatin; Staining and Labeling; Streptozocin; Thymidine | 1991 |
Glucagon immunoneutralization in diabetic rats normalizes urea synthesis and decreases nitrogen wasting.
Topics: Alanine; Animals; Antibodies; Blood Glucose; Diabetes Mellitus, Experimental; Female; Glucagon; Nitrogen; Organ Specificity; Rabbits; Rats; Rats, Inbred Strains; Reference Values; Regression Analysis; Urea | 1992 |
Rates and tissue sites of noninsulin- and insulin-mediated glucose uptake in diabetic rats.
Topics: Animals; Biological Transport; Blood Glucose; Diabetes Mellitus, Experimental; Glucagon; Glucose; Glucose Clamp Technique; Insulin; Male; Organ Specificity; Rats; Rats, Inbred Strains; Reference Values | 1992 |
Nickel-induced hyperglycaemia: the role of insulin and glucagon.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Female; Glucagon; Glycogen; Homeostasis; Hyperglycemia; Injections, Intraperitoneal; Insulin; Liver; Nickel; Radioimmunoassay; Rats; Rats, Inbred Strains | 1992 |
Progressive and concurrent deterioration of vagus-stimulated and hypoglycemia-induced glucagon secretion in streptozotocin-diabetic rats.
Topics: Animals; Arginine; Diabetes Mellitus, Experimental; Electric Stimulation; Glucagon; Hypoglycemia; Insulin; Rats; Rats, Inbred Strains; Vagus Nerve | 1992 |
Oral insulin in diabetic dogs.
Topics: Administration, Oral; Animals; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Experimental; Dogs; Female; Gastrointestinal Transit; Glucagon; Glucose; Insulin; Intestinal Absorption; Liver; Male; Regional Blood Flow; Tablets, Enteric-Coated | 1991 |
[Preventive effect of bombesin on alloxan-induced diabetes in rat].
Topics: Alloxan; Animals; Blood Glucose; Bombesin; Cells, Cultured; Diabetes Mellitus, Experimental; Glucagon; Insulin; Insulin Secretion; Islets of Langerhans; Male; Rats; Rats, Inbred Strains | 1991 |
Putative role of endogenous insulin in cysteamine-induced hypersecretion of gastric acid in rats.
Topics: Animals; Blood Glucose; Brain Chemistry; Cysteamine; Deoxyglucose; Diabetes Mellitus, Experimental; Gastric Acid; Gastric Mucosa; Glucagon; Glucose; Insulin; Male; Peptic Ulcer; Rats; Rats, Inbred Strains | 1991 |
Central adrenergic suppression augments the insulin and glucagon secretory, and the glycogenolytic responses in streptozotocin-diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Clonidine; Diabetes Mellitus, Experimental; Glucagon; Glycogen; Insulin; Insulin Secretion; Norepinephrine; Rabbits; Rats; Rats, Inbred WF; Sympathetic Nervous System | 1991 |
Comparison of beta-cell function after long-term treatment with either insulin, insulin plus gliclazide or gliclazide in neonatal streptozotocin-induced non-insulin-dependent diabetic rats.
Topics: Animals; Animals, Newborn; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Drug Therapy, Combination; Eating; Gliclazide; Glucagon; Glucose Tolerance Test; Insulin; Islets of Langerhans; Male; Pancreas; Rats; Rats, Inbred Strains; Streptozocin; Time Factors | 1991 |
Plasma insulin and glucagon and their release from pancreatic islet in hyperosmolar diabetic rat.
Topics: Animals; Arginine; Blood Glucose; Dehydration; Diabetes Mellitus, Experimental; Glucagon; Hydrocortisone; Insulin; Islets of Langerhans; Male; Osmotic Pressure; Rats; Rats, Inbred Strains; Streptozocin | 1991 |
Increased insulin action in cultured hepatocytes from rats with diabetes induced by neonatal streptozotocin.
Topics: Aminoisobutyric Acids; Animals; Animals, Newborn; Blood Glucose; Cells, Cultured; Diabetes Mellitus, Experimental; Female; Glucagon; Gluconeogenesis; Glucose; Glycogen; Insulin; Lipids; Liver; Protein-Tyrosine Kinases; Rats; Rats, Inbred Strains; Receptor, Insulin | 1991 |
Effect of physical training on ventricular beta-adrenergic receptor adenylate cyclase system of diabetic rats.
Topics: Adenylyl Cyclases; Animals; Binding, Competitive; Blood Glucose; Diabetes Mellitus, Experimental; Glucagon; Guanylyl Imidodiphosphate; Iodocyanopindolol; Isoproterenol; Male; Myocardium; Physical Conditioning, Animal; Pindolol; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Sodium Fluoride | 1991 |
Reciprocal changes of plasma glucose and ketone bodies in fasted and acutely diabetic rats after CNS stimulation.
Topics: Animals; Blood Glucose; Brain; Diabetes Mellitus, Experimental; Epinephrine; Fasting; Fatty Acids, Nonesterified; Glucagon; Hepatic Veins; Injections, Intraventricular; Ketone Bodies; Male; Neostigmine; Rats; Rats, Inbred Strains | 1991 |
Interactions between oxytocin, glucagon and glucose in normal and streptozotocin-induced diabetic rats.
Topics: Analysis of Variance; Animals; Diabetes Mellitus, Experimental; Glucagon; Glucose; Male; Oxytocin; Rats; Rats, Inbred Strains; Streptomycin | 1991 |
Determination of G-protein levels, ADP-ribosylation by cholera and pertussis toxins and the regulation of adenylyl cyclase activity in liver plasma membranes from lean and genetically diabetic (db/db) mice.
Topics: Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Blotting, Western; Cell Membrane; Cholera Toxin; Colforsin; Diabetes Mellitus, Experimental; Glucagon; GTP-Binding Proteins; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Isoproterenol; Liver; Male; Mice; Mice, Inbred C57BL; Pertussis Toxin; Virulence Factors, Bordetella | 1991 |
Paradoxical reduction in pancreatic glucagon with normalization of somatostatin and decrease in insulin in normoglycemic alloxan-diabetic dogs: a putative mechanism of glucagon irresponsiveness to hypoglycemia.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Glucagon; Insulin; Islets of Langerhans; Pancreas; Somatostatin | 1990 |
Fetal pig pancreas. Preparation and assessment of tissue for transplantation, and its in vivo development and function in athymic (nude) mice.
Topics: Animals; Culture Media; Culture Techniques; Diabetes Mellitus, Experimental; Fetus; Gestational Age; Glucagon; Immunoenzyme Techniques; Insulin; Insulin Secretion; Mice; Mice, Nude; Pancreas; Pancreas Transplantation; Somatostatin; Swine; Transplantation, Heterologous | 1990 |
Changes in the pancreatic A-, B- and D-cell populations during development of diabetes in spontaneously diabetic Chinese hamsters of the Asahikawa colony (CHAD).
Topics: Animals; Cricetinae; Cricetulus; Diabetes Mellitus, Experimental; Female; Glucagon; Immunoenzyme Techniques; Insulin; Islets of Langerhans; Male; Pancreas; Somatostatin | 1990 |
Abnormal regulation by glucose of somatostatin secretion in the perfused pancreas of NIDDM rats.
Topics: Animals; Arginine; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Female; Glucagon; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Rats; Rats, Inbred Strains; Somatostatin | 1990 |
[The effect of growth hormone-releasing factor (GRF) on secretion of insulin, glucagon and somatostatin from perfused rat pancreas].
Topics: Animals; Diabetes Mellitus, Experimental; Glucagon; Growth Hormone-Releasing Hormone; Humans; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Pancreas; Perfusion; Propranolol; Rats; Rats, Inbred Strains; Somatostatin | 1990 |
Sequential morphological changes in pancreatic islets of spontaneously diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Glucagon; Glucose Tolerance Test; Immunoenzyme Techniques; Immunohistochemistry; Insulin; Islets of Langerhans; Male; Pancreas; Pancreatic Polypeptide; Rats; Somatostatin | 1990 |
CNS stimulation does not affect hepatic venous glucose concentration in severely diabetic rats.
Topics: Animals; Blood Glucose; Cerebral Ventricles; Diabetes Mellitus, Experimental; Epinephrine; Glucagon; Injections, Intraventricular; Liver Circulation; Liver Glycogen; Male; Neostigmine; Norepinephrine; Rats; Rats, Inbred Strains; Reference Values | 1991 |
Secretion of proglucagon-derived peptides in response to intestinal luminal nutrients.
Topics: Animal Nutritional Physiological Phenomena; Animals; Diabetes Mellitus, Experimental; Duodenum; Glucagon; Glucose; Intestinal Mucosa; Male; Peptides; Perfusion; Proglucagon; Protein Precursors; Radioimmunoassay; Rats | 1991 |
Whole body and hepatic insulin action in normal, starved, and diabetic rats.
Topics: Animals; Corticosterone; Diabetes Mellitus, Experimental; Epinephrine; Glucagon; Glucose; Glucose Clamp Technique; Insulin; Insulin Infusion Systems; Liver; Male; Norepinephrine; Rats; Rats, Inbred Strains; Reference Values; Starvation | 1991 |
Transplantation of purified islet cells in diabetic rats. II. Immunogenicity of allografted islet beta-cells.
Topics: Animals; Blood Glucose; Cell Aggregation; Cell Separation; Diabetes Mellitus, Experimental; Glucagon; Histocompatibility Antigens Class II; Insulin; Islets of Langerhans; Islets of Langerhans Transplantation; Liver; Microscopy, Electron; Pancreas; Rats; Rats, Inbred BN; Rats, Inbred Strains; Transplantation, Homologous; Weight Gain | 1991 |
Evidence for an insulin resistance in the adult offspring of pregnant streptozotocin-diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Fatty Acids, Nonesterified; Female; Glucagon; Glucose Clamp Technique; Insulin; Insulin Infusion Systems; Insulin Resistance; Pregnancy; Pregnancy in Diabetics; Rats; Rats, Inbred Strains; Reference Values | 1991 |
Morphological alterations and biochemical reactions of syngeneic pancreatic islets grafted into the liver of diabetic Lewis rats.
Topics: Animals; Diabetes Mellitus, Experimental; Glucagon; Insulin; Insulin Secretion; Islets of Langerhans Transplantation; Kinetics; Liver; Microscopy, Electron; Perfusion; Rats; Rats, Inbred Lew; Transplantation, Heterotopic | 1990 |
Immunosuppression and pancreatic islet transplantation.
Topics: Animals; Arginine; Diabetes Mellitus, Experimental; Dogs; Glucagon; Glucose Tolerance Test; Graft Rejection; Immunosuppressive Agents; Insulin; Insulin Secretion; Islets of Langerhans Transplantation | 1990 |
Experiments on a new hollow fiber membrane for immuno isolated transplantation of islets of Langerhans.
Topics: Animals; Artificial Organs; Diabetes Mellitus, Experimental; Glucagon; Insulin; Insulin Secretion; Islets of Langerhans Transplantation; Male; Membranes, Artificial; Rats; Rats, Inbred Lew | 1990 |
Stimulation of gastric glucagon secretion by epinephrine administration in dogs.
Topics: Animals; Diabetes Mellitus, Experimental; Dogs; Epinephrine; Gastric Mucosa; Glucagon; Propranolol; Secretory Rate; Stimulation, Chemical | 1990 |
Insulinlike effects of vanadate on hepatic glycogen metabolism in nondiabetic and streptozocin-induced diabetic rats.
Topics: Alanine Transaminase; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Female; Glucagon; Glycogen-Synthase-D Phosphatase; Insulin; Liver; Liver Glycogen; Phosphorylase Kinase; Phosphorylase Phosphatase; Protein Kinases; Rats; Rats, Inbred Strains; Reference Values; Vanadates; Vanadium | 1990 |
Influence of long-term diabetes on liver glycogen metabolism in the rat.
Topics: Age Factors; Animals; Diabetes Mellitus, Experimental; Fasting; Glucagon; Glucose-6-Phosphate; Glucosephosphates; Glucosyltransferases; Glycogen Synthase; Insulin; Liver Glycogen; Male; Rats; Rats, Inbred Strains | 1990 |
Reduced insulinotropic effects of glucagonlike peptide I-(7-36)-amide and gastric inhibitory polypeptide in isolated perfused diabetic rat pancreas.
Topics: Animals; Animals, Newborn; Blood Glucose; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Insulin; Pancreas; Peptide Fragments; Peptides; Perfusion; Rats; Rats, Inbred Strains; Streptozocin | 1990 |
Development of cytotoxic islet cell antibodies in rats following damage of the pancreas by complete Freund's adjuvant combined with a nondiabetogenic dose of streptozotocin.
Topics: Animals; Antibody Formation; Blood Glucose; Cytotoxicity Tests, Immunologic; Diabetes Mellitus, Experimental; Freund's Adjuvant; Glucagon; Insulin; Islets of Langerhans; Male; Pancreas; Rats; Rats, Inbred Strains; Streptozocin; Tumor Cells, Cultured | 1990 |
Studies on regulatory mechanisms of heme biosynthesis in hepatocytes from normal and experimental-diabetic rats. Role of insulin.
Topics: 5-Aminolevulinate Synthetase; Animals; Cyclic AMP; Cytochrome P-450 Enzyme System; Dexamethasone; Diabetes Mellitus, Experimental; Enzyme Induction; Ferrochelatase; Glucagon; Heme; In Vitro Techniques; Insulin; Liver; Male; Phenobarbital; Rats | 1990 |
Further studies of enhanced growth of pancreatic carcinoma in diabetes.
Topics: Animals; Blood Glucose; Body Weight; Cricetinae; Diabetes Mellitus, Experimental; Eating; Fatty Acids, Nonesterified; Glucagon; Insulin; Male; Mesocricetus; Pancreatic Neoplasms; Tumor Cells, Cultured | 1990 |
Suppressive effect of glucose administration on the binding of prolactin by rat liver.
Topics: Adrenalectomy; Amino Acids; Animals; Diabetes Mellitus, Experimental; Dietary Fats; Dietary Proteins; Female; Glucagon; Glucose; Growth Hormone; Hypophysectomy; Insulin; Liver; Mammary Neoplasms, Experimental; Ovariectomy; Prolactin; Rats; Rats, Inbred Strains; Sucrose; Sympathectomy | 1990 |
Adjustment of blood sugar levels with insulin and glucagon eyedrops in normal and diabetic rabbits.
Topics: Adjuvants, Pharmaceutic; Administration, Topical; Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Female; Glucagon; Insulin; Ophthalmic Solutions; Polidocanol; Polyethylene Glycols; Rabbits; Radioimmunoassay | 1990 |
Delayed stomach to caecum transit time in the diabetic rat. Possible role of hyperglucagonaemia.
Topics: Animals; Cecum; Diabetes Mellitus, Experimental; Electrophysiology; Gastrointestinal Transit; Glucagon; Male; Rats; Rats, Inbred Strains; Stomach | 1990 |
Regulation of the expression of the serine dehydratase gene in the kidney and liver of the rat.
Topics: Animals; Blotting, Western; Dexamethasone; Diabetes Mellitus, Experimental; Enzyme Induction; Gene Expression Regulation, Enzymologic; Glucagon; Kidney; L-Serine Dehydratase; Liver; Male; Rats; Rats, Inbred Strains; RNA, Messenger | 1990 |
Abnormal insulin secretion in a streptozocin model of diabetes. Effects of insulin treatment.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arginine; Blood Glucose; Diabetes Mellitus, Experimental; Glucagon; Insulin; Insulin Secretion; Islets of Langerhans; Male; Rats; Rats, Inbred Strains | 1985 |
Transcriptional and post-transcriptional regulation of L-type pyruvate kinase in diabetic rat liver by insulin and dietary fructose.
Topics: Adrenalectomy; Animals; Cell Nucleus; Cycloheximide; Cytosol; Diabetes Mellitus, Experimental; Fructose; Glucagon; Insulin; Kinetics; Male; Pyruvate Kinase; Rats; Rats, Inbred Strains; RNA; RNA, Messenger; Transcription, Genetic; Triiodothyronine | 1985 |
Relationship between the severity of diabetes mellitus and pancreatic exocrine dysfunction in rats.
Topics: Amylases; Animals; Blood Glucose; Ceruletide; Diabetes Mellitus, Experimental; Glucagon; Insulin; Male; Pancreas; Pancreatic Function Tests; Pancreatic Juice; Proteins; Rats; Rats, Inbred Strains; Streptozocin; Trypsinogen | 1985 |
Relationship between renal function and metabolic alterations in early streptozocin-induced diabetes in rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glomerular Filtration Rate; Glucagon; Humans; Insulin; Kidney; Kidney Cortex; Male; Nucleotides; Organ Size; Rats; RNA | 1987 |
Analysis of pancreatic islet cells and hormone content in the spontaneously diabetic KKAy mouse by morphometry, immunocytochemistry and radioimmunoassay.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucagon; Glycated Hemoglobin; Immunohistochemistry; Insulin; Islets of Langerhans; Mice; Mice, Inbred C57BL; Mice, Obese; Pancreatic Hormones; Pancreatic Polypeptide; Radioimmunoassay; Somatostatin; Staining and Labeling | 1987 |
Pancreatic lipase and colipase activity increase in pancreatic acinar tissue of diabetic rats.
Topics: Amylases; Animals; Blood Glucose; Colipases; Diabetes Mellitus, Experimental; Female; Glucagon; Insulin; Lipase; Pancreas; Proteins; Rats; Rats, Inbred Strains; Rats, Zucker; Reference Values; Triglycerides | 1989 |
Glucagon desensitization of adenylate cyclase and stimulation of inositol phospholipid metabolism does not involve the inhibitory guanine nucleotide regulatory protein Gi, which is inactivated upon challenge of hepatocytes with glucagon.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Diabetes Mellitus, Experimental; Glucagon; GTP-Binding Proteins; Inositol Phosphates; Liver; Pertussis Toxin; Rats; Rats, Inbred Strains; Sugar Phosphates; Virulence Factors, Bordetella | 1989 |
Control of glycogen synthase and phosphorylase in hepatocytes from diabetic rats. Effects of glucagon, vasopressin, and vanadate.
Topics: Animals; Arginine Vasopressin; Calcium; Diabetes Mellitus, Experimental; Glucagon; Glycogen Synthase; Kinetics; Liver; Male; Phosphorylases; Rats; Rats, Inbred Strains; Reference Values; Vanadates | 1989 |
Guanine nucleotide binding regulatory proteins and adenylate cyclase in livers of streptozotocin- and BB/Wor-diabetic rats. Immunodetection of Gs and Gi with antisera prepared against synthetic peptides.
Topics: Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Aluminum; Angiotensin II; Animals; Catalysis; Cell Line; Cell Membrane; Cholera Toxin; Colforsin; Diabetes Mellitus, Experimental; Enzyme Activation; Fluorine; Glucagon; GTP-Binding Proteins; Guanosine Triphosphate; Immune Sera; Injections, Intraperitoneal; Liver; Male; Peptide Fragments; Pertussis Toxin; Rats; Rats, Inbred BB; Rats, Inbred Strains; Virulence Factors, Bordetella | 1989 |
[Islet transplantation in type II diabetes mellitus--model of the spontaneous diabetic Cohen rat].
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucagon; Glycated Hemoglobin; Insulin; Islets of Langerhans Transplantation; Rats; Rats, Inbred Strains | 1989 |
Characterization of exercise-induced hyperketonemia in streptozotocin-diabetic rats and the effects on it of prolonged training.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Ketoacidosis; Fatty Acids, Nonesterified; Glucagon; Insulin; Ketone Bodies; Male; Physical Exertion; Rats; Rats, Inbred Strains; Time Factors | 1989 |
Arginine stimulated insulin and glucagon release from islets transplanted into the liver of diabetic rats.
Topics: Animals; Arginine; Diabetes Mellitus, Experimental; Female; Glucagon; Insulin; Insulin Secretion; Islets of Langerhans; Islets of Langerhans Transplantation; Liver; Rats; Rats, Inbred Lew | 1989 |
Islet transplantation to the renal subcapsular space in streptozotocin-diabetic rats. Long-term effects on insulin and glucagon secretion.
Topics: Animals; Arginine; Blood Glucose; Diabetes Mellitus, Experimental; Glucagon; Glucose; Insulin; Insulin Secretion; Islets of Langerhans Transplantation; Kidney; Male; Rats; Rats, Inbred Strains | 1989 |
Insulin and glucagon secretion in streptozotocin-diabetic rats: influences of islets transplanted to the renal subcapsular space.
Topics: Animals; Arginine; Blood Glucose; Diabetes Mellitus, Experimental; Glucagon; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Islets of Langerhans Transplantation; Male; Rats; Rats, Inbred Strains; Time Factors | 1989 |
Morphometrical and biochemical differences of endocrine pancreata between spontaneously hypertensive and normotensive rats with or without neonatal streptozotocin-induced diabetes.
Topics: Animals; Blood Glucose; Blood Pressure; Body Weight; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Female; Glucagon; Hypertension; Insulin; Islets of Langerhans; Organ Size; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Streptozocin | 1989 |
Increased beta-cell secretory responsiveness to ceruletide and TPA in streptozocin-induced mildly diabetic rats.
Topics: Animals; Arginine; Carbachol; Ceruletide; Diabetes Mellitus, Experimental; Glucagon; Glucose; Insulin; Islets of Langerhans; Male; Rats; Rats, Inbred Strains; Streptozocin; Tetradecanoylphorbol Acetate | 1989 |
A comparison between insulin and glucagon release from orthotopically-placed islets of Langerhans and after their transplantation into the liver of diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Female; Glucagon; Glucose; Insulin; Islets of Langerhans; Islets of Langerhans Transplantation; Liver; Rats; Rats, Inbred Lew; Streptozocin; Transplantation, Autologous | 1989 |
Effect of pinealectomy and of diabetes on liver insulin and glucagon receptor concentrations in the rat.
Topics: Animals; Blood Glucose; Cell Membrane; Diabetes Mellitus, Experimental; Glucagon; Insulin; Liver; Male; Pineal Gland; Rats; Rats, Inbred Strains; Receptor, Insulin; Receptors, Gastrointestinal Hormone; Receptors, Glucagon; Streptozocin | 1989 |
Effect of diabetes on hormone-stimulated and basal hepatocyte calcium metabolism.
Topics: Animals; Arginine Vasopressin; Calcium; Cells, Cultured; Diabetes Mellitus, Experimental; Epinephrine; Glucagon; Inositol 1,4,5-Trisphosphate; Kinetics; Liver; Male; Phentolamine; Phosphorylases; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Reference Values | 1989 |
Effect of dietary carbohydrates on insulin and glucagon receptors in a new model of noninsulin-dependent diabetes-SHR/N-corpulent rat.
Topics: Animals; Blood Glucose; Cell Membrane; Cholesterol; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dietary Carbohydrates; Glucagon; Insulin; Obesity; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Receptor, Insulin; Receptors, Gastrointestinal Hormone; Receptors, Glucagon; Starch; Sucrose; Triglycerides | 1989 |
Decreased glucagon binding and glucagon-stimulated lipolysis in adipocytes from streptozotocin-diabetic rats.
Topics: Adipose Tissue; Animals; Diabetes Mellitus, Experimental; Dihydroalprenolol; Glucagon; Isoproterenol; Lipolysis; Male; Rats; Rats, Inbred Strains; Receptors, Gastrointestinal Hormone; Receptors, Glucagon | 1989 |
Multiple defects occur in the guanine nucleotide regulatory protein system in liver plasma membranes of obese (fa/fa) but not lean (Fa/Fa) Zucker rats: loss of functional Gi and abnormal Gs function.
Topics: Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Blotting, Western; Cell Membrane; Cholera Toxin; Colforsin; Diabetes Mellitus, Experimental; Glucagon; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Insulin Resistance; Liver; Male; NAD; Obesity; Pertussis Toxin; Phosphorus Radioisotopes; Rats; Rats, Inbred Strains; Rats, Zucker; Receptors, Gastrointestinal Hormone; Receptors, Glucagon; Virulence Factors, Bordetella | 1989 |
Growth hormone and somatostatin in the plasma of transiently diabetic ducks: basal variation and response to glucose.
Topics: Animals; Diabetes Mellitus, Experimental; Ducks; Glucagon; Glucose; Growth Hormone; Insulin; Male; Pancreatectomy; Somatostatin; Time Factors | 1989 |
Maternal and fetal endocrine pancreas in the spontaneously diabetic BB rat.
Topics: Animals; Diabetes Mellitus, Experimental; Female; Glucagon; Insulin; Islets of Langerhans; Microscopy, Electron; Organ Size; Pregnancy; Pregnancy in Diabetics; Rats; Rats, Inbred BB; Somatostatin | 1989 |
Morphological aspects of glucagon and somatostatin islet cells in diabetic bio breeding and low-dose streptozocin-treated Wistar rats.
Topics: Animals; Diabetes Mellitus, Experimental; Female; Glucagon; Islets of Langerhans; Male; Rats; Rats, Inbred BB; Rats, Inbred Strains; Reference Values; Somatostatin | 1989 |
Indirect effect of catecholamines on development of insulin resistance in skeletal muscle from diabetic rats.
Topics: Adrenergic beta-Antagonists; Animals; Biological Transport; Blood Glucose; Catecholamines; Diabetes Mellitus, Experimental; Epinephrine; Fatty Acids, Nonesterified; Glucagon; Glucose; Glycogen; Insulin; Insulin Resistance; Male; Muscles; Propranolol; Rats; Rats, Inbred Strains; Streptozocin | 1989 |
Glucagon secretion and alpha-cell sensitivity to somatostatin in genetically diabetic mice C57BL/KsJ-mdb.
Topics: Age Factors; Animals; Diabetes Mellitus, Experimental; Female; Glucagon; Islets of Langerhans; Male; Mice; Mice, Inbred C57BL; Pancreas; Perfusion; Somatostatin | 1989 |
Effects of acute sodium salicylate on the abnormal counterregulatory glucagon and epinephrine responses to insulin hypoglycemia in diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Epinephrine; Glucagon; Hypoglycemia; Indomethacin; Insulin; Male; Rats; Rats, Inbred Strains; Sodium Salicylate | 1989 |
Molecular and cellular responses of islets during perturbations of glucose homeostasis determined by in situ hybridization histochemistry.
Topics: Animals; Base Sequence; Diabetes Mellitus, Experimental; Genes; Glucagon; Glucose; Glucose Clamp Technique; Homeostasis; Hyperglycemia; Islets of Langerhans; Mice; Mice, Obese; Molecular Sequence Data; Nucleic Acid Hybridization; Oligonucleotide Probes; Pancreatectomy; Proglucagon; Proinsulin; Protein Precursors; Rats; Rats, Inbred Strains; Reference Values; RNA, Messenger | 1989 |
Phlorizin-induced normoglycemia partially restores glucoregulation in diabetic dogs.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Dopamine; Epinephrine; Female; Glucagon; Homeostasis; Insulin; Kinetics; Male; Norepinephrine; Phlorhizin; Reference Values | 1989 |
Alloxan-induced diabetes mellitus in the pregnant ewe: metabolic and cardiovascular effects on the mother and her fetus.
Topics: Animals; Diabetes Mellitus, Experimental; Female; Fetal Hypoxia; Glucagon; Hyperglycemia; Hyperinsulinism; Insulin; Ketone Bodies; Pregnancy; Pregnancy Complications, Cardiovascular; Pregnancy in Diabetics; Sheep; Sheep Diseases | 1989 |
[Comparative effects of traditional Chinese medicines (dai-saiko-to, hatimi-zio-gan and byakko-ka-ninzin-to) on experimental diabetes and hyperlipidemia].
Topics: Animals; Blood Glucose; Body Weight; Cholesterol; Cyproheptadine; Diabetes Mellitus, Experimental; Drugs, Chinese Herbal; Glucagon; Hyperlipidemias; Insulin; Male; Rats; Rats, Inbred Strains | 1989 |
Calmodulin-induced early-onset diabetes in transgenic mice.
Topics: Aging; Animals; Blood Glucose; Calmodulin; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Female; Genetic Vectors; Glucagon; Insulin; Islets of Langerhans; Mice; Mice, Transgenic; Reference Values; Signal Transduction | 1989 |
Effect of the fatty acid oxidation inhibitor methyl palmoxirate (methyl 2-tetradecylglycidate) on recovery from insulin-induced hypoglycemia in diabetic dogs.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Epoxy Compounds; Ethers, Cyclic; Glucagon; Glucose; Hypoglycemia; Insulin; Liver; Propionates | 1989 |
Diabetes and impaired response of glucagon cells and vascular bed to adenosine in rat pancreas.
Topics: Adenosine; Animals; Diabetes Mellitus, Experimental; Glucagon; In Vitro Techniques; Insulin; Islets of Langerhans; Kinetics; Male; Pancreas; Perfusion; Rats; Rats, Inbred Strains; Reference Values; Regional Blood Flow | 1989 |
[Studies on glucose metabolism and pancreatic endocrine function after simultaneous major resection of the liver and pancreas].
Topics: Animals; Arginine; Diabetes Mellitus, Experimental; Dogs; Female; Glucagon; Glucose; Glucose Tolerance Test; Hepatectomy; Hypertrophy; Insulin; Insulin Secretion; Islets of Langerhans; Liver; Male; Pancreatectomy; Regeneration | 1989 |
Normal insulin sensitivity during the phase of glucose intolerance but insulin resistance at the onset of diabetes in the spontaneously diabetic BB rat.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Crosses, Genetic; Diabetes Mellitus, Experimental; Epinephrine; Fatty Acids, Nonesterified; Female; Glucagon; Glucose; Glucose Clamp Technique; Hydroxybutyrates; Insulin; Insulin Resistance; Male; Norepinephrine; Prediabetic State; Rats; Rats, Inbred BB; Reference Values | 1989 |
Regulation of the hepatic response to glucagon: role of insulin, growth hormone and cortisol.
Topics: Alanine; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Female; Glucagon; Gluconeogenesis; Growth Hormone; Hydrocortisone; Insulin; Liver; Pituitary Neoplasms; Rats; Rats, Inbred Strains | 1989 |
Phosphoenolpyruvate carboxykinase activity patterns in the liver acinus of diabetic and diabetic and estrogen treated rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Estradiol; Female; Glucagon; Insulin; Liver; Male; Phosphoenolpyruvate Carboxykinase (GTP); Rats; Rats, Inbred Strains; Sex Factors | 1989 |
Effects of chronic sodium salicylate feeding on the impaired glucagon and epinephrine responses to insulin-induced hypoglycaemia in streptozotocin diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Epinephrine; Glucagon; Male; Rats; Rats, Inbred Strains; Reference Values; Sodium Salicylate | 1989 |
Tissue-specific differences in the levels of proglucagon-derived peptides in streptozotocin-induced diabetes.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucagon; Hypothalamus; Ileum; Male; Medulla Oblongata; Muscle, Smooth; Organ Specificity; Pancreas; Proglucagon; Protein Precursors; Rats; Rats, Inbred Strains; Reference Values; RNA, Messenger | 1989 |
Characterization of glucagon-like peptide-1-(7-36)amide in the hypothalamus.
Topics: Animals; Diabetes Mellitus, Experimental; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Hypothalamus; Immunohistochemistry; Peptide Fragments; Peptides; Rats; Rats, Inbred Strains | 1989 |
Glucagon binding and lipolytic response in isolated adipocytes from streptozotocin-diabetic rats.
Topics: Adipose Tissue; Animals; Cell Separation; Cyclic AMP; Diabetes Mellitus, Experimental; Glucagon; Male; Rats; Rats, Inbred Strains | 1988 |
Reversal of D- and A-cell insensitivity to glucose in alloxan-diabetic dogs by treatment with the artificial beta cell (Biostator).
Topics: Animals; Arginine; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Glucagon; Glucose; Insulin; Insulin Infusion Systems; Islets of Langerhans; Somatostatin | 1985 |
Unresponsiveness to glucose in a streptozocin model of diabetes. Inappropriate insulin and glucagon responses to a reduction of glucose concentration.
Topics: Animals; Arginine; Blood Glucose; Diabetes Mellitus, Experimental; Epinephrine; Glucagon; Glucose; Humans; Insulin; Insulin Secretion; Islets of Langerhans; Male; Rats; Rats, Inbred Strains; Somatostatin | 1985 |
Intra-splenic transplantation of allogenic isolated pancreatic islets in nonimmunosuppressed rats. A morphological immunocytochemical study.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Fluorescent Antibody Technique; Glucagon; Insulin; Islets of Langerhans; Islets of Langerhans Transplantation; Male; Rats; Rats, Inbred Strains; Somatostatin; Spleen; Transplantation, Homologous | 1985 |
Effects of a thiazide diuretic (hydroflumethiazide) and a loop diuretic (bumetanide) on the endocrine pancreas: studies in vitro.
Topics: Animals; Blood Glucose; Bumetanide; Diabetes Mellitus, Experimental; Diuretics; Dogs; Glucagon; Hydroflumethiazide; Insulin; Insulin Secretion; Islets of Langerhans; Pancreatic Hormones; Perfusion; Somatostatin | 1985 |
Insulin, glucagon and somatostatin content of the non-obese diabetic (NOD) mouse pancreas and plasma virus antibodies to Coxsackie B- and reoviruses.
Topics: Animals; Antibodies, Viral; Blood Glucose; Diabetes Mellitus, Experimental; Enterovirus B, Human; Female; Glucagon; Insulin; Male; Mice; Mice, Inbred Strains; Pancreas; Pancreatic Hormones; Reoviridae; Somatostatin | 1985 |
Important role of glucagon during exercise in diabetic dogs.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Fatty Acids, Nonesterified; Glucagon; Glucose; Kinetics; Liver; Male; Physical Exertion; Somatostatin | 1985 |
Role of beta-adrenergic mechanisms during exercise in poorly controlled diabetes.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Epinephrine; Fatty Acids, Nonesterified; Glucagon; Glucose; Kinetics; Lactates; Lactic Acid; Liver; Male; Norepinephrine; Physical Exertion; Propranolol; Receptors, Adrenergic, beta; Somatostatin | 1985 |
Ontogeny of cells containing insulin, glucagon, pancreatic polypeptide hormone and somatostatin in the bovine pancreas.
Topics: Animals; Cattle; Diabetes Mellitus, Experimental; Fetus; Fluorescent Antibody Technique; Glucagon; Insulin; Islets of Langerhans; Pancreatic Hormones; Pancreatic Polypeptide; Rats; Rats, Brattleboro; Rats, Inbred Strains; Somatostatin | 1985 |
Antidiabetic effects of subfractions from fenugreek seeds in diabetic dogs.
Topics: Animals; Diabetes Mellitus, Experimental; Dogs; Glucagon; Glucose Tolerance Test; Hypoglycemic Agents; Insulin; Plants, Medicinal; Seeds; Somatostatin | 1986 |
Insulin and glucagon response of the diabetic Chinese hamster in the Asahikawa colony.
Topics: Animals; Arginine; Blood Glucose; Cricetinae; Cricetulus; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Female; Glucagon; Glucose; Glucose Tolerance Test; Insulin; Islets of Langerhans; Male; Pancreas; Somatostatin | 1985 |
Effect of adrenalectomy on the pancreas of db/db mice.
Topics: Adrenalectomy; Animals; Body Weight; Diabetes Mellitus, Experimental; Disease Models, Animal; Glucagon; Histocytochemistry; Immunologic Techniques; Insulin; Islets of Langerhans; Mice; Mice, Inbred C57BL; Somatostatin | 1986 |
Relationship of glucagon suppression by insulin and somatostatin to the ambient glucose concentration.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Glucagon; Insulin; Phlorhizin; Somatostatin | 1987 |
[Immunohistochemical studies of fetal and maternal endocrine pancreases during pregnancy and the puerperium in streptozotocin-induced diabetic rats].
Topics: Animals; Diabetes Mellitus, Experimental; Female; Glucagon; Insulin; Islets of Langerhans; Pregnancy; Pregnancy in Diabetics; Rats; Somatostatin | 1986 |
Insulin, glucagon and somatostatin content in normal and diabetic duck pancreas.
Topics: Animals; Diabetes Mellitus, Experimental; Ducks; Glucagon; Insulin; Male; Pancreas; Pancreatectomy; Somatostatin; Spleen; Tissue Distribution | 1987 |
Importance of glucagon in the control of futile cycling as studied in alloxan-diabetic dogs.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Fatty Acids, Nonesterified; Glucagon; Glucose; Insulin; Kinetics; Liver; Somatostatin | 1987 |
Pancreatic hormones in streptozotocin-diabetic rats.
Topics: Animals; Blood Glucose; Carbachol; Diabetes Mellitus, Experimental; Glucagon; Glucose Tolerance Test; Immunohistochemistry; In Vitro Techniques; Insulin; Islets of Langerhans; Leucine; Male; Pancreas; Pancreatic Polypeptide; Rats; Rats, Inbred Strains; Somatostatin; Streptozocin | 1986 |
Pancreatic A- and D-cell response to arginine during acute alloxan-induced intra-islet insulinopenia.
Topics: Alloxan; Animals; Arginine; Diabetes Mellitus, Experimental; Glucagon; Insulin Infusion Systems; Islets of Langerhans; Male; Rats; Rats, Inbred Strains; Somatostatin | 1988 |
Induction of nesidioblastosis will reverse diabetes in Syrian golden hamster.
Topics: Animals; Blood Glucose; Cell Division; Cricetinae; Diabetes Mellitus, Experimental; Glucagon; Immunohistochemistry; Insulin; Islets of Langerhans; Mesocricetus; Nitrogen; Organ Size; Pancreatic Diseases; Somatostatin; Streptozocin | 1988 |
Effect of insulin on basal pancreaticoduodenal output of somatostatin in normal and diabetic dogs.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Duodenum; Glucagon; Insulin; Insulin Secretion; Pancreas; Somatostatin | 1988 |
Aldrin epoxidase activity in liver microsomes from normal or streptozotocin-diabetic rats: comparison with activity in isolated hepatocytes from normal rats incubated with glucagon.
Topics: Animals; Cytochrome P-450 Enzyme System; Diabetes Mellitus, Experimental; Glucagon; Liver; Microsomes, Liver; Mixed Function Oxygenases; Phosphorylation; Rats; Streptozocin | 1987 |
Beta endorphin modulation of the glucoregulatory effects of repeated epinephrine infusion in alloxan-diabetic and normal dogs.
Topics: Animals; beta-Endorphin; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Dose-Response Relationship, Drug; Epinephrine; Fatty Acids, Nonesterified; Glucagon; Hydrocortisone; Infusions, Intravenous; Insulin | 1987 |
Biochemical changes in rhesus monkey during the first days after streptozotocin administration are indicative of selective beta cell destruction.
Topics: Animals; Blood Glucose; C-Peptide; Diabetes Mellitus, Experimental; Free Radicals; Glucagon; Glycated Hemoglobin; Islets of Langerhans; Macaca mulatta; Streptozocin | 1988 |
[Paradoxical hyperglucagonemia after oral administration of glucose in diabetic dogs. Impact of the cholinergic nervous system].
Topics: Administration, Oral; Animals; Blood Glucose; Cholinergic Fibers; Diabetes Mellitus, Experimental; Dogs; Glucagon; Glucose; Injections, Intravenous; Insulin | 1987 |
[Combined administration of sodium chloro-2-propionate and insulin on the secretion of glucagon by the pancreas in the diabetic rat].
Topics: Animals; Arginine; Diabetes Mellitus, Experimental; Drug Combinations; Glucagon; Glucose; Hydrocarbons, Chlorinated; Insulin; Pancreas; Propionates; Rats; Rats, Inbred Strains | 1988 |
Dietary and hormonal regulation of aldolase B gene expression.
Topics: Adrenalectomy; Animals; Arginine; Cyclic AMP; Diabetes Mellitus, Experimental; Dietary Carbohydrates; Fructose-Bisphosphate Aldolase; Gene Expression Regulation; Glucagon; Hormones; Intestine, Small; Kidney; Liver; Male; Parathyroid Glands; Rats; Rats, Inbred Strains; RNA, Messenger; Thyroidectomy | 1985 |
Metabolic zonation in liver of diabetic rats. Zonal distribution of phosphoenolpyruvate carboxykinase, pyruvate kinase, glucose-6-phosphatase and succinate dehydrogenase.
Topics: Animals; Cell Fractionation; Centrifugation, Zonal; Diabetes Mellitus, Experimental; Glucagon; Glucose-6-Phosphatase; Insulin; Liver; Male; Phosphoenolpyruvate Carboxykinase (GTP); Pyruvate Kinase; Rats; Rats, Inbred Strains; Subcellular Fractions; Succinate Dehydrogenase | 1985 |
Age-related change in ketone body metabolism: diminished glucagon effect on ketogenesis in adult rats.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Aging; Animals; Carnitine; Cyclic AMP; Diabetes Mellitus, Experimental; Fatty Acids, Nonesterified; Glucagon; Glucose; Hydroxybutyrates; Insulin; Ketone Bodies; Liver; Male; Rats; Rats, Inbred Strains | 1987 |
Dietary and hormonal regulation of L-type pyruvate kinase gene expression in rat small intestine.
Topics: Adrenalectomy; Animals; Bucladesine; Cortisone; Cyclic AMP; Diabetes Mellitus, Experimental; Diet; Dietary Carbohydrates; Fasting; Gene Expression Regulation; Genes; Glucagon; Intestine, Small; Isoenzymes; Parathyroid Glands; Pyruvate Kinase; Rats; Rats, Inbred Strains; RNA, Messenger; Thyroidectomy | 1987 |
Alterations in the myocardial beta-adrenoceptor system of streptozotocin-diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Calcium; Catecholamines; Colforsin; Diabetes Mellitus, Experimental; Electric Stimulation; Glucagon; Glycated Hemoglobin; In Vitro Techniques; Isoproterenol; Male; Methoxamine; Myocardial Contraction; Myocardium; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta | 1987 |
Synthesis of two glucagon antagonists: receptor binding, adenylate cyclase, and effects on blood plasma glucose levels.
Topics: Adenylyl Cyclase Inhibitors; Animals; Binding, Competitive; Blood Glucose; Cell Membrane; Chemical Phenomena; Chemistry; Diabetes Mellitus, Experimental; Glucagon; Liver; Male; Rats; Rats, Inbred Strains; Receptors, Gastrointestinal Hormone; Receptors, Glucagon | 1987 |
Roles of hormonal and nutritional factors in the regulation of rat liver alcohol dehydrogenase activity and ethanol elimination rate in vivo.
Topics: Alcohol Dehydrogenase; Animals; Depression, Chemical; Diabetes Mellitus, Experimental; Dietary Carbohydrates; Dietary Fats; Ethanol; Fasting; Food; Glucagon; Insulin; Liver; Male; Rats; Rats, Inbred Strains | 1988 |
Changes in plasma glucagon, pancreatic polypeptide and insulin during development of alloxan diabetes mellitus in dog.
Topics: Animals; Diabetes Mellitus, Experimental; Dogs; Glucagon; Hyperglycemia; Immunohistochemistry; Injections, Intravenous; Insulin; Pancreatic Polypeptide | 1988 |
Alteration of insulin and glucagon secretion from the perfused BB rat pancreas before and after the onset of diabetes.
Topics: Aging; Animals; Diabetes Mellitus, Experimental; Glucagon; Insulin; Insulin Secretion; Islets of Langerhans; Perfusion; Rats; Rats, Inbred BB; Rats, Inbred Strains; Reference Values | 1988 |
Pituitary, hypothalamic and pancreatic 7B2 concentrations in rats with streptozotocin-induced diabetes and spontaneously diabetic mice.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucagon; Hypothalamus; Immunohistochemistry; Insulin; Male; Mice; Mice, Inbred Strains; Mice, Obese; Nerve Tissue Proteins; Neuroendocrine Secretory Protein 7B2; Pancreas; Pituitary Gland; Pituitary Hormones; Rats; Rats, Inbred Strains | 1988 |
Diabetogenic effects of N-nitrosomethylurea in rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Female; Glucagon; Glucose; Insulin; Islets of Langerhans; Male; Methylnitrosourea; Rats; Rats, Inbred Strains | 1988 |
Exogenous hyperglucagonaemia in insulin controlled diabetic rats increases urea excretion and nitrogen loss from organs.
Topics: Alanine; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Female; Glucagon; Insulin; Nitrogen; Rats; Rats, Inbred Strains; Reference Values; Urea | 1988 |
Spontaneous diabetes in Macaca nigra: relevance to human beings with NIDDM.
Topics: Animals; Autoantibodies; Blood Glucose; Diabetes Mellitus, Experimental; Disease Models, Animal; Glucagon; Glucose Tolerance Test; Glycated Hemoglobin; Humans; Insulin; Islets of Langerhans; Macaca; Prediabetic State; Reference Values | 1988 |
Metabolic control in diabetic dogs treated with pancreatic autotransplants and insulin pumps.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Gastric Inhibitory Polypeptide; Glucagon; Insulin; Insulin Infusion Systems; Islets of Langerhans; Islets of Langerhans Transplantation; Pancreatectomy; Pancreatic Polypeptide; Transplantation, Autologous | 1986 |
Hormone release, islet yield, and transplantation of fetal and neonatal rat dorsal and ventral pancreatic islets.
Topics: Animals; Animals, Newborn; Diabetes Mellitus, Experimental; Female; Fetus; Glucagon; Insulin; Insulin Secretion; Islets of Langerhans; Islets of Langerhans Transplantation; Rats; Rats, Inbred Lew; Rats, Inbred Strains | 1986 |
Sulfonylurea-induced inhibition of glucagon secretion from the perfused rat pancreas: evidence for a direct, non-paracrine effect.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucagon; Glyburide; In Vitro Techniques; Male; Pancreas; Perfusion; Rats; Rats, Inbred Strains; Sulfonylurea Compounds; Tolazamide | 1986 |
Treatment of streptozotocin-diabetic rats with metformin restores the ability of insulin to inhibit adenylate cyclase activity and demonstrates that insulin does not exert this action through the inhibitory guanine nucleotide regulatory protein Gi.
Topics: Adenylyl Cyclase Inhibitors; Animals; Cell Membrane; Diabetes Mellitus, Experimental; Glucagon; GTP-Binding Proteins; Insulin; Liver; Male; Metformin; Rats; Rats, Inbred Strains | 1988 |
Role of glucagon in intestinal hyperemia associated with early experimental diabetes mellitus.
Topics: Animals; Diabetes Mellitus, Experimental; Glucagon; Hyperemia; Intestines; Muscles; Rats; Rats, Inbred Strains | 1988 |
Isolation and characterisation of GLP-1 7-36 amide from rat intestine. Elevated levels in diabetic rats.
Topics: Animals; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Colon; Diabetes Mellitus, Experimental; Eating; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Ileum; Intestinal Mucosa; Intestines; Mass Spectrometry; Molecular Weight; Peptide Fragments; Peptides; Rats; Rats, Inbred Strains; Tissue Distribution | 1988 |
Use of a selectively permeabilized isolated rat hepatocyte preparation to study changes in the properties of overt carnitine palmitoyltransferase activity in situ.
Topics: Acyltransferases; Animals; Carnitine O-Palmitoyltransferase; Cell Separation; Diabetes Mellitus, Experimental; Digitonin; Female; Glucagon; Glycerophosphates; In Vitro Techniques; Insulin; L-Lactate Dehydrogenase; Liver; Palmitoyl Coenzyme A; Permeability; Rats; Rats, Inbred Strains; Starvation | 1988 |
Strict insulin therapy normalises organ nitrogen contents and the capacity of urea nitrogen synthesis in experimental diabetes in rats.
Topics: Alanine; Animals; Body Composition; Body Weight; Diabetes Mellitus, Experimental; Energy Metabolism; Female; Glucagon; Insulin; Nitrogen; Rats; Rats, Inbred Strains; Urea | 1988 |
[Changes in carbohydrate metabolism after major resection of the pancreas, with special reference to the fibrotic pancreas caused by ligation of the pancreatic duct].
Topics: Animals; Carbohydrate Metabolism; Diabetes Mellitus, Experimental; Dogs; Female; Fibrosis; Glucagon; Insulin; Insulin Secretion; Islets of Langerhans; Ligation; Male; Pancreas; Pancreatectomy; Pancreatic Ducts | 1988 |
Role of calcium in suppression of glucagon release from isolated diabetic rat pancreata.
Topics: Animals; Calcium; Diabetes Mellitus, Experimental; Glucagon; Glucose; In Vitro Techniques; Insulin; Male; Pancreas; Perfusion; Rats; Rats, Inbred Strains | 1988 |
Regulation of rat liver glycogen phosphorylase concentration by in vivo relative levels of glucagon and insulin.
Topics: Animals; Diabetes Mellitus, Experimental; Glucagon; Hyperthyroidism; Hypothyroidism; Immune Sera; Insulin; Liver; Male; Phosphorylases; Propylthiouracil; Rats; Rats, Inbred Strains; Triiodothyronine | 1987 |
Role of glucagon suppression on gluconeogenesis during insulin treatment of the conscious diabetic dog.
Topics: Animals; Diabetes Mellitus, Experimental; Dogs; Female; Glucagon; Gluconeogenesis; Insulin; Liver; Male; Pancreatectomy | 1987 |
Effects of streptozotocin-induced diabetes and diet on nitrogen loss from organs and on the capacity of urea synthesis in rats.
Topics: Animals; Diabetes Mellitus, Experimental; Female; Glucagon; Insulin; Nitrogen; Proteins; Rats; Rats, Inbred Strains; Urea | 1987 |
Hormonal responses during development of streptozotocin diabetes in rats.
Topics: Animals; Corticosterone; Diabetes Mellitus, Experimental; Glucagon; Glucose Tolerance Test; Growth; Hyperglycemia; Insulin; Insulin Secretion; Islets of Langerhans; Male; Rats; Rats, Inbred Strains | 1987 |
The effects of subtotal pancreatectomy on renal growth in streptozotocin diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Female; Glucagon; Kidney; Organ Size; Pancreatectomy; Rats; Rats, Inbred Strains | 1988 |
Antecedent chronic hyperglycaemia blocks phlorizin-induced insulin resistance in the dog.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Glucagon; Glycosuria; Hyperglycemia; Insulin Resistance; Kidney; Male; Phlorhizin | 1988 |
[Studies of simultaneous major resection of the liver and pancreas, with special reference to carbohydrate metabolism].
Topics: Animals; Blood Glucose; Carbohydrate Metabolism; Diabetes Mellitus, Experimental; Dogs; Female; Glucagon; Liver; Male; Pancreas | 1988 |
Glucoregulation in alloxan-diabetic dogs.
Topics: Animals; Blood Glucose; Catecholamines; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Dogs; Glucagon; Humans; Insulin; Liver; Phlorhizin | 1986 |
Effect of physical training on norepinephrine turnover in tissues of normal and diabetic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucagon; Growth; Insulin; Liver; Male; Muscles; Myocardium; Norepinephrine; Pancreas; Physical Education and Training; Rats; Rats, Inbred Strains | 1986 |
Simulation of the normal glucopenia-induced decline in insulin partially restores the glucagon response to glucopenia in isolated perfused pancreata of streptozotocin-diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Glucagon; Glucose; In Vitro Techniques; Insulin; Male; Pancreas; Rats; Rats, Inbred Strains | 1986 |
An H-2 alloantiserum preserves beta-cell function in mice made diabetic by low-dose streptozocin.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucagon; H-2 Antigens; Immunization, Passive; Insulin; Insulin Secretion; Islets of Langerhans; Male; Mice; Mice, Inbred C57BL | 1986 |
Lifelong reversal of the metabolic abnormalities of advanced diabetes in rats by whole-pancreas transplantation.
Topics: Animals; Blood Glucose; Blood Urea Nitrogen; Body Weight; Creatinine; Diabetes Mellitus, Experimental; Glucagon; Glucose Tolerance Test; Insulin; Pancreas Transplantation; Rats; Rats, Inbred Lew; Time Factors | 1986 |
Receptor-mediated endocytosis of polypeptide hormones is a regulated process: inhibition of [125I]iodoinsulin internalization in hypoinsulinemic diabetes of rat and man.
Topics: Adolescent; Adult; Animals; Autoradiography; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Endocytosis; Female; Glucagon; Humans; In Vitro Techniques; Insulin; Iodine Radioisotopes; Liver; Male; Radioligand Assay; Rats; Receptor, Insulin | 1986 |
Selective impairment of pancreatic A cell suppression by glucose during acute alloxan-induced insulinopenia: in vitro study on isolated perfused rat pancreas.
Topics: Alloxan; Animals; Arginine; Diabetes Mellitus, Experimental; Glucagon; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Male; Perfusion; Rats; Rats, Inbred Strains | 1986 |
Effects of alloxan on S-adenosylmethionine metabolism in the rat liver.
Topics: Alloxan; Animals; Diabetes Mellitus, Experimental; Glucagon; Insulin; Kinetics; Liver; Methionine Adenosyltransferase; Methyltransferases; Phosphatidylethanolamine N-Methyltransferase; Rats; S-Adenosylmethionine | 1986 |
The effect of insulin-induced hypoglycaemia on the secretion of glucagon and hepatic glucose production in pancreatectomized dogs.
Topics: Animals; Diabetes Mellitus, Experimental; Dogs; Glucagon; Glucose; Hypoglycemia; Insulin; Liver; Pancreatectomy | 1986 |
Loss of insulin response to glucose but not arginine during the development of autoimmune diabetes in BB/W rats: relationships to islet volume and glucose transport rate.
Topics: Age Factors; Animals; Arginine; Autoimmune Diseases; Biological Transport; Diabetes Mellitus, Experimental; Glucagon; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Rats; Rats, Inbred Strains; Secretory Rate | 1986 |
The endocrine pancreas aspects of beta-cell function in relation to morphology, insulin secretion and insulin content.
Topics: Animals; Diabetes Mellitus, Experimental; Food; Glucagon; Guinea Pigs; Insulin; Islets of Langerhans; Mice; Rats | 1986 |
Large changes in food intake in diabetic rats fed high-fat and low-fat diets.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Dietary Carbohydrates; Dietary Fats; Drinking; Eating; Female; Glucagon; Insulin; Male; Organ Size; Rats; Rats, Inbred Strains | 1986 |
Morphologic and functional changes in sympathetic nerve relationships with pancreatic alpha-cells after destruction of beta-cells in rats.
Topics: Animals; Diabetes Mellitus, Experimental; Female; Glucagon; Humans; Islets of Langerhans; Male; Norepinephrine; Rats; Rats, Inbred BB; Rats, Inbred Strains; Sympathetic Nervous System; Tyramine | 1987 |
Increased capacity of urea synthesis in streptozotocin diabetes in rats.
Topics: Animals; Blood Glucose; Blood Urea Nitrogen; Diabetes Mellitus, Experimental; Female; Glucagon; Insulin; Kinetics; Rats; Rats, Inbred Strains; Urea | 1986 |
Metabolic basis for the diabetogenic action of growth hormone in the obese (ob/ob) mouse.
Topics: Adipose Tissue; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Female; Glucagon; Gluconeogenesis; Glucose; Glycogen; Growth Hormone; Insulin; Insulin-Like Growth Factor I; Liver; Mice; Mice, Inbred C57BL; Mice, Obese; Muscles; Obesity | 1987 |
Effects of metabolic factors in the diabetic state on the in vitro development of preimplantation mouse embryos.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Blastocyst; Culture Techniques; Diabetes Mellitus, Experimental; Embryonic and Fetal Development; Female; Glucagon; Glucose; Hydroxybutyrates; Insulin; Ketone Bodies; Mice; Pregnancy; Pregnancy in Diabetics | 1987 |
Cytotoxic activity of sera from diabetic BB rats against BB rat islet--a functional study.
Topics: Animals; Animals, Suckling; Autoantibodies; Cell Division; Cytotoxicity, Immunologic; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; DNA; Glucagon; Insulin; Islets of Langerhans; Rats; Rats, Brattleboro; Rats, Mutant Strains | 1987 |
Studies on the activation in vitro of carnitine palmitoyltransferase I in liver mitochondria from normal, diabetic and glucagon-treated rats.
Topics: Acyltransferases; Animals; Carnitine O-Palmitoyltransferase; Diabetes Mellitus, Experimental; Enzyme Activation; Glucagon; Mitochondria, Liver; Palmitoyl Coenzyme A; Rats; Starvation | 1987 |
Rat liver and intestinal mucosa differ in the developmental pattern and hormonal regulation of carbamoyl-phosphate synthetase I and ornithine carbamoyl transferase gene expression.
Topics: Animals; Carbamoyl-Phosphate Synthase (Ammonia); Dexamethasone; Diabetes Mellitus, Experimental; DNA; Gene Expression Regulation; Glucagon; Hormones; Intestinal Mucosa; Ligases; Liver; Methylation; Nucleic Acid Hybridization; Ornithine Carbamoyltransferase; Rats; Rats, Inbred Strains; RNA, Messenger | 1986 |
Release of glucagon-like immunoreactive material (GLI) from the isolated perfused jejunum of normal and diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Glucagon; Glucagon-Like Peptides; Glucose; In Vitro Techniques; Jejunum; Male; Peptides; Perfusion; Rats; Rats, Inbred Strains | 1985 |
Correction of hyperglycemia with phloridzin restores the glucagon response to glucose in insulin-deficient dogs: implications for human diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Dogs; Glucagon; Glucose; Hyperglycemia; Islets of Langerhans; Phlorhizin | 1985 |
Enhanced intestinal insulinotropic effect in streptozotocin-diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Gastrointestinal Hormones; Glucagon; Glucose; Insulin; Insulin Secretion; Intestinal Mucosa; Islets of Langerhans; Male; Perfusion; Radioimmunoassay; Rats; Rats, Inbred Strains; Stimulation, Chemical | 1985 |
Influence of plasma hormone levels on various stimulant-induced hepatic DNA synthesis in carbon tetrachloride-intoxicated rats.
Topics: Animals; Carbachol; Carbon Tetrachloride Poisoning; Catecholamines; Diabetes Mellitus, Experimental; DNA; Glucagon; Hormones; Insulin; Isoproterenol; Liver; Liver Regeneration; Male; Pancreatic Hormones; Parasympathomimetics; Rats; Rats, Inbred Strains; Stimulation, Chemical; Thyroid Diseases; Time Factors; Triiodothyronine | 1985 |
The effect of experimental diabetes on phenylalanine metabolism in isolated liver cells.
Topics: Animals; Diabetes Mellitus, Experimental; Glucagon; In Vitro Techniques; Insulin; Liver; Male; Norepinephrine; Phenylalanine; Phenylalanine Hydroxylase; Protein Biosynthesis; Rats; Rats, Inbred Strains | 1985 |
Morphology of the endocrine pancreas in diabetic sand rat (Psammomys obesus).
Topics: Animals; Arvicolinae; Blood Glucose; Diabetes Mellitus, Experimental; Female; Glucagon; Insulin; Islets of Langerhans; Male; Microscopy, Electron; Obesity; Reference Values | 1985 |
Amino acids in normal and diabetic ducks.
Topics: Amino Acids; Animals; Diabetes Mellitus, Experimental; Ducks; Glucagon; Insulin; Male; Pancreatectomy; Time Factors | 1985 |
The effect of glucagon administration on protein synthesis in skeletal muscles, heart and liver in vivo.
Topics: Amino Acids; Animals; Diabetes Mellitus, Experimental; Glucagon; Heart; Insulin; Liver; Male; Muscle Proteins; Muscles; Myocardium; Protein Biosynthesis; Rats; Rats, Inbred Strains | 1985 |
Diminished glucagon response to epinephrine in physically trained diabetic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Epinephrine; Glucagon; Hyperglycemia; Insulin; Male; Physical Endurance; Rats; Rats, Inbred Strains | 1985 |
Cardiac adenylate cyclase activity in streptozotocin-treated rats after 4 months of diabetes: impairment of epinephrine and glucagon stimulation.
Topics: Adenylyl Cyclases; Animals; Calcium; Cardiomyopathies; Cell Membrane; Diabetes Mellitus, Experimental; Epinephrine; Glucagon; Insulin; Male; Myocardium; Rats; Rats, Inbred Strains | 1985 |
Effect of sodium 2-chloropropionate on glucagon secretion in the rat.
Topics: Alanine; Animals; Arginine; Diabetes Mellitus, Experimental; Glucagon; Glycosuria; Hydrocarbons, Chlorinated; Male; Pancreas; Perfusion; Propionates; Rats; Rats, Inbred Strains | 1985 |
The effect of different hyperglucagonemic states on monooxygenase activities and isozymic pattern of cytochrome P-450 in mouse.
Topics: Animals; Cytochrome P-450 Enzyme System; Diabetes Mellitus, Experimental; Fasting; Glucagon; Isoenzymes; Male; Mice; Mice, Inbred C57BL; Microsomes, Liver; Oxygenases | 1985 |
Streptozotocin-induced diabetes and hormone sensitivity of adenylate cyclase in rat myocardial sarcolemma, aorta and liver.
Topics: Adenylyl Cyclases; Animals; Aorta; Catecholamines; Colforsin; Corpus Striatum; Diabetes Mellitus, Experimental; Diterpenes; Glucagon; Guanosine Triphosphate; Hormones; Liver; Male; Myocardium; Rats; Rats, Inbred Strains; Sarcolemma | 1985 |
Mechanism of allylisopropylacetamide-induced increase of delta-aminolevulinate synthetase in liver mitochondria. Effects of administration of glucose, cyclic AMP, and some hormones related to glucose metabolism.
Topics: 5-Aminolevulinate Synthetase; Acetamides; Adenosine Triphosphate; Allylisopropylacetamide; Animals; Bucladesine; Cyclic AMP; Cycloheximide; Cytosol; Diabetes Mellitus, Experimental; Enzyme Induction; Epinephrine; Ethylenediamines; Glucagon; Glucose; Glutamate Dehydrogenase; Half-Life; Insulin; Isoproterenol; Kinetics; Liver; Male; Mitochondria, Liver; Rats; Succinate Dehydrogenase; Theophylline; Time Factors; Tyrosine Transaminase | 1974 |
[Antidiabetic action of niamide].
Topics: Animals; Diabetes Mellitus, Experimental; Glucagon; Niacinamide; Rabbits | 1967 |
Selective effects of insulin on hepatic epinephrine responsive adenyl cyclase activity.
Topics: Adenylyl Cyclases; Adrenal Glands; Adrenalectomy; Animals; Carbon Isotopes; Chromatography, Thin Layer; Depression, Chemical; Diabetes Mellitus; Diabetes Mellitus, Experimental; Epinephrine; Female; Glucagon; Injections, Intraperitoneal; Injections, Subcutaneous; Insulin; Liver; Prednisolone; Rats; Stimulation, Chemical; Streptozocin; Testosterone; Time Factors | 1972 |
Intermediate cells of the pancreas. 3. Selective autophagy and destruction of beta-granules in intermediate cells of the rat pancreas induced by alloxan and streptozotocin.
Topics: Alloxan; Animals; Cytoplasm; Cytoplasmic Granules; Diabetes Mellitus, Experimental; Glucagon; Glycine max; Injections, Intraperitoneal; Islets of Langerhans; Microscopy, Electron; Pancreas; Rats; Streptozocin; Trypsin Inhibitors | 1973 |
The role of cyclic AMP in the control of liver metabolism.
Topics: Adenine Nucleotides; Adrenalectomy; Animals; Catecholamines; Cyclic AMP; Dexamethasone; Diabetes Mellitus, Experimental; Glucagon; Gluconeogenesis; In Vitro Techniques; Insulin; Insulin Antibodies; Liver; Perfusion; Rats | 1968 |
Cyclic guanosine 3',5'-monophosphate in mammalian tissues and urine.
Topics: Animals; Brain Chemistry; Chromatography, Thin Layer; Cyclic AMP; Diabetes Mellitus; Diabetes Mellitus, Experimental; Dogs; Epinephrine; Glucagon; Guanine Nucleotides; Insulin; Kidney; Ligases; Liver; Male; Methods; Phosphoric Monoester Hydrolases; Phosphotransferases; Pyruvate Kinase; Pyruvates; Rats; Sodium Chloride; Stimulation, Chemical; Theophylline; Time Factors; Tritium | 1969 |
Effects of glucagon on amino acid transport and utilization in the perfused rat liver.
Topics: Amino Acids; Animals; Biological Transport, Active; Carbon Isotopes; Cyclic AMP; Depression, Chemical; Diabetes Mellitus, Experimental; Fasting; Glucagon; In Vitro Techniques; Liver; Perfusion; Rats; Stimulation, Chemical | 1969 |
Dietary and hormonal effects on gluconeogenesis and glycogenesis from pyrute-3-14C, fructose-U-14C and glycerol-2-14C in the rat.
Topics: Animals; Blood Glucose; Carbon Isotopes; Catecholamines; Cyclic AMP; Diabetes Mellitus, Experimental; Dietary Carbohydrates; Fructose; Glucagon; Gluconeogenesis; Glucose; Glycerol; Glycogen; Insulin; Insulin Antagonists; Insulin Antibodies; Insulin Secretion; Liver; Liver Glycogen; Pyruvates; Rats | 1970 |
Role of adenosine 3',5'-monophosphate in the control of gluconeogenesis.
Topics: Adenine Nucleotides; Adrenal Glands; Adrenalectomy; Animals; Carbon Isotopes; Catecholamines; Cyclic AMP; Diabetes Mellitus, Experimental; Fatty Acids; Glucagon; Gluconeogenesis; Glucose; Immune Sera; Insulin; Lactates; Liver; Pyruvates; Rats; Urea | 1970 |
Effect of ethanol on glycerol metabolism in rat liver during different hormonal conditions.
Topics: Animals; Cyclic AMP; Diabetes Mellitus, Experimental; Ethanol; Glucagon; Glycerol; Glycerolphosphate Dehydrogenase; Glycerophosphates; Glycolysis; In Vitro Techniques; Insulin; Liver; Male; Phosphotransferases; Rats | 1970 |
Regulation of glycogen metabolism in the adrenal gland. 3. Hormonal effects in vivo.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Animals; Corticosterone; Diabetes Mellitus, Experimental; Epinephrine; Glucagon; Glucose; Glycogen; Hormones; Hypophysectomy; Insulin; Insulin Antibodies; Male; Pancreatectomy; Rats; Starvation | 1971 |
A specific, reversible, macromolecular inhibitor of hepatic glucagon responsive adenyl cyclase.
Topics: Adenine Nucleotides; Adenylyl Cyclase Inhibitors; Adrenal Glands; Adrenalectomy; Aminopeptidases; Animals; Binding Sites; Carbon Isotopes; Cell Membrane; Chromatography, Thin Layer; Cytoplasm; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Epinephrine; Feedback; Female; Glucagon; Liver; Macromolecular Substances; Phosphoric Monoester Hydrolases; Rats | 1971 |
-Oxoglutarate carboxylation in liver mitochondria from normal, alloxan diabetic and streptozotocin diabetic rats.
Topics: Animals; Caprylates; Carbon Dioxide; Carnitine; Citrates; Citric Acid Cycle; Cyclic AMP; Depression, Chemical; Diabetes Mellitus; Diabetes Mellitus, Experimental; Fumarates; Glucagon; In Vitro Techniques; Insulin; Ketoglutaric Acids; Malates; Male; Mitochondria, Liver; Rats; Streptozocin; Succinates | 1972 |
Mechanisms in cellular metabolic regulation.
Topics: Animals; Animals, Newborn; Carcinoma, Hepatocellular; Cortisone; Dactinomycin; Diabetes Mellitus, Experimental; Diet; Fasting; Glucagon; Hydro-Lyases; Isoenzymes; L-Serine Dehydratase; Leucine; Liver; Liver Neoplasms; Models, Biological; Molecular Biology; Neoplasms, Experimental; Rats; RNA, Messenger; Tritium | 1971 |
Rat liver histidase: glucose repression and half-life after casein hydrolysate feeding.
Topics: Amino Acids; Animal Nutritional Physiological Phenomena; Animals; Blood Glucose; Butyrates; Caseins; Cyclic AMP; Diabetes Mellitus, Experimental; Diet; Dietary Proteins; Enzyme Induction; Enzyme Repression; Glucagon; Glucose; Half-Life; Histidine; Insulin; Liver; Lyases; Male; Protein Deficiency; Proteins; Rats; Starvation | 1972 |
Dietary and hormonal regulation of hepatic biosynthetic and catabolic enzymes of serine metabolism in rats.
Topics: Adrenal Glands; Alcohol Oxidoreductases; Animals; Butyrates; Cortisone; Cyclic AMP; Diabetes Mellitus, Experimental; Diet; Fasting; Glucagon; Gluconeogenesis; Insulin; L-Serine Dehydratase; Liver; Male; Rats; Serine; Transaminases | 1972 |
Relationship of some hepatic actions of insulin to the intracellular level of cyclic adenylate.
Topics: Adipose Tissue; Animals; Caffeine; Carbon Isotopes; Cyclic AMP; Diabetes Mellitus, Experimental; Epinephrine; Glucagon; Gluconeogenesis; Glucose; Glycogen; In Vitro Techniques; Insulin; Ketone Bodies; Liver; Male; Potassium; Rats; Urea | 1972 |
Studies on gluconeogenesis, protein synthesis and cyclic AMP levels in isolated parenchymal cells following insulin withdrawal from alloxan diabetic rats.
Topics: Alanine; Amino Acids; Animals; Carbon Isotopes; Cyclic AMP; Diabetes Mellitus, Experimental; Fructose; Glucagon; Gluconeogenesis; In Vitro Techniques; Insulin, Long-Acting; Kinetics; Lactates; Liver; Male; Protein Biosynthesis; Pyruvates; Rats; Starvation; Stimulation, Chemical; Theophylline | 1972 |
A comparison of the responses of mitochondrial and cytosol histidine-pyruvate aminotransferases to nutritional and hormonal treatments.
Topics: Adrenal Glands; Adrenalectomy; Animal Nutritional Physiological Phenomena; Animals; Butyrates; Cyclic AMP; Cytosol; Diabetes Mellitus, Experimental; Dietary Proteins; Drug Synergism; Epinephrine; Glucagon; Histidine; Hydrocortisone; Hydrogen-Ion Concentration; Insulin; Liver; Male; Mitochondria, Liver; Pyruvates; Rats; Transaminases | 1973 |
Mechanism of control of hepatic glycogenesis by insulin.
Topics: Animals; Blood Glucose; Carbon Isotopes; Cyclic AMP; Diabetes Mellitus, Experimental; Drug Synergism; Enzyme Activation; Glucagon; Glucose; Glucosephosphates; Glucosyltransferases; Glycogen Synthase; Insulin; Liver; Liver Glycogen; Male; Perfusion; Protein Kinases; Rats | 1973 |
Effects of insulin on gluconeogenesis and cyclic AMP levels in perfused livers from diabetic rats.
Topics: Adenine Nucleotides; Animals; Blood Glucose; Carbon Dioxide; Carbon Radioisotopes; Coenzyme A; Cyclic AMP; Diabetes Mellitus, Experimental; Freezing; Glucagon; Gluconeogenesis; Glucose; In Vitro Techniques; Insulin; Lactates; Liver; Liver Glycogen; Male; Perfusion; Phosphoenolpyruvate Carboxykinase (GTP); Pyruvate Carboxylase; Pyruvates; Rats; Urea | 1973 |
Effects of glucagon on cyclic AMP and carbohydrate metabolism in livers from diabetic rats.
Topics: Adenylyl Cyclases; Animals; Calcium; Carbohydrate Metabolism; Cell Membrane; Cyclic AMP; Diabetes Mellitus; Diabetes Mellitus, Experimental; Glucagon; Guanosine Triphosphate; Kinetics; Liver; Magnesium; Male; Ouabain; Phosphoric Diester Hydrolases; Rats; Streptozocin; Theophylline | 1974 |
Inhibition of hepatic drug metabolism by cyclic 3',5'-adenosine monophosphate.
Topics: Aniline Compounds; Animals; Bucladesine; Cyclic AMP; Diabetes Mellitus, Experimental; Glucagon; Hexobarbital; In Vitro Techniques; Insulin; Liver; Male; Perfusion; Rats; Sleep; Starvation; Theophylline; Time Factors | 1972 |
The activities of nicotinamide mononucleotide adenylyltransferase and of nicotinamide-adenine dinucleotide kinase in the livers of rats subjected to different hormonal treatments.
Topics: Adenine Nucleotides; Adrenalectomy; Animals; Diabetes Mellitus, Experimental; Glucagon; Growth Hormone; Liver; N-Glycosyl Hydrolases; NAD; NADP; Nucleotidyltransferases; Phosphotransferases; Rats; Thyroxine | 1965 |
Somatostatin-induced changes in insulin and glucagon secretion in normal and diabetic dogs.
Topics: Alanine; Animals; Blood Glucose; Caseins; Diabetes Mellitus, Experimental; Dogs; Duodenum; Glucagon; Glucose; Growth Hormone; Homeostasis; Hypothalamus; Insulin; Insulin Secretion; Pancreas; Peptides; Sodium Chloride | 1974 |
Comparative hyperglycemic responses to norepinephrine salbutamol and glucagon in normal and alloxan-diabetic insulin-controlled rabbits.
Topics: Albuterol; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucagon; Insulin; Male; Norepinephrine; Propranolol; Rabbits; Time Factors | 1974 |
Suppressive effect of secretin upon pancreatic alpha cell function.
Topics: Animals; Depression, Chemical; Diabetes Mellitus, Experimental; Dogs; Glucagon; Glucose; Hydrochloric Acid; Hyperglycemia; Insulin; Islets of Langerhans; Male; Secretin | 1972 |
Abnormal pancreatic alpha-cell function in bacterial infections.
Topics: Adolescent; Adult; Animals; Bacterial Infections; Blood Glucose; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimental; Dogs; Fever; Glucagon; Humans; Insulin; Islets of Langerhans; Middle Aged; Pneumococcal Infections; Pneumonia | 1973 |
[Comparative studies on islet and enterochromaffin cells from alloxan treated rabbits].
Topics: Animals; Chromaffin System; Cytoplasmic Granules; Diabetes Mellitus, Experimental; Glucagon; Hypoglycemia; Islets of Langerhans; Pancreas; Rabbits | 1973 |
The effect of insulin on the alpha-cell response to hyperglycemia in long-standing alloxan diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Dogs; Glucagon; Glucose; Hyperglycemia; Insulin; Islets of Langerhans; Time Factors | 1974 |
[Preliminary studies on the action of deoxycorticosterone, glucagon, and insulin on the isotopic ratio 13C-12C of respiratory CO2 in the rat].
Topics: Adrenalectomy; Animals; Carbon Dioxide; Carbon Isotopes; Corticosterone; Diabetes Mellitus, Experimental; Glucagon; Injections, Intramuscular; Injections, Subcutaneous; Insulin; Male; Mass Spectrometry; Pancreatectomy; Rats | 1972 |
Diabetes in the sand-rat: diabetogenesis, responses to mannoheptulose and atriplex ash.
Topics: Animals; Basal Metabolism; Blood Glucose; Cataract; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diet; Disaccharides; Glucagon; Glucose Tolerance Test; Glycosuria; Heptoses; Hyperglycemia; Mannose; Obesity; Plants, Medicinal; Rats; Respiration; Species Specificity | 1972 |
[Effect of insulin and glucagon on the postheparinic plasma activity in normal and diabetic rats].
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucagon; Heparin; Insulin; Lipoprotein Lipase; Rats; Triglycerides | 1972 |
Evidence for a role of endogenous insulin and glucagon in the regulation of potassium homeostasis.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Glucagon; Homeostasis; Hyperglycemia; Hyperkalemia; Hypoglycemia; Infusions, Parenteral; Insulin; Insulin Secretion; Insulin, Long-Acting; Potassium; Potassium Chloride; Spectrophotometry, Atomic | 1973 |
The influence of insulin and glucagon on hydroxymethylglutaryl coenzyme A reductase activity in rat liver.
Topics: Alcohol Oxidoreductases; Animals; Blood Glucose; Body Weight; Circadian Rhythm; Diabetes Mellitus, Experimental; Glucagon; Glutarates; Insulin; Liver; Male; Mevalonic Acid; Rats; Time Factors | 1973 |
Hepatic autography in uncontrolled experimental diabetes and its relationships to insulin and glucagon.
Topics: Animals; Diabetes Mellitus, Experimental; Glucagon; Insulin; Liver; Lysosomes; Male; Microscopy, Electron; Phagocytosis; Rats | 1974 |
The effect of hormones and hormone inhibitors on blood sugar regulation and the follicles of Langerhans in ammocoete larvae.
Topics: Animals; Blood Glucose; Cobalt; Diabetes Mellitus, Experimental; Endocrine Glands; Fishes; Glucagon; Glucose Tolerance Test; Glycogen; Glycosuria; Histocytochemistry; Insulin; Intestinal Mucosa; Islets of Langerhans; Liver Glycogen; Muscles | 1969 |
The effect of experimental insulin deficiency on glucagon secretion.
Topics: Animals; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diazoxide; Dogs; Glucagon; Heptoses; Hexoses; Hyperglycemia; Insulin; Insulin Antibodies; Islets of Langerhans; Rats | 1971 |
Control of alloxan diabetes in dogs by islet cell transplantation.
Topics: Animals; Atrophy; Blood Glucose; Diabetes Mellitus, Experimental; Disease Models, Animal; Dogs; Glucagon; Islets of Langerhans Transplantation; Pancreas; Pancreatectomy; Tolbutamide; Transplantation, Homologous | 1971 |
Studies on the induction and repression of enzymes in rat liver. VI. Some properties and the metabolic regulation of two isozymic forms of serine dehydratase.
Topics: Adrenal Glands; Adrenalectomy; Amino Acids; Animal Nutritional Physiological Phenomena; Animals; Chromatography, DEAE-Cellulose; Cortisone; Crystallization; Diabetes Mellitus, Experimental; Electrophoresis, Disc; Enzyme Induction; Glucagon; Hydro-Lyases; Immune Sera; Immunodiffusion; Isoenzymes; L-Serine Dehydratase; Leucine; Liver; Lysine; Male; Molecular Weight; Phosphates; Proline; Pyridoxal Phosphate; Rats; Spectrophotometry; Tritium; Ultraviolet Rays | 1971 |
Studies of the development of diabetic ketosis in the rat.
Topics: Acetates; Acetoacetates; Acidosis; Animals; Blood Glucose; Body Weight; Carbon Isotopes; Cholesterol; Diabetes Mellitus, Experimental; Fatty Acids; Fatty Acids, Nonesterified; Glucagon; Hydroxybutyrates; Insulin; Liver; Male; Phospholipids; Radioimmunoassay; Rats; Triglycerides | 1972 |
Control of gluconeogenesis in liver. V. Effects of fasting, diabetes, and glucagon on lactate and endogenous metabolism in the perfused rat liver.
Topics: Animals; Carbon Dioxide; Carbon Isotopes; Cholesterol; Citric Acid Cycle; Diabetes Mellitus, Experimental; Fasting; Fatty Acids; Glucagon; Gluconeogenesis; In Vitro Techniques; Insulin; Ketone Bodies; Lactates; Lipids; Liver; Liver Glycogen; Male; Oxygen Consumption; Perfusion; Protein Biosynthesis; Rats; Urea | 1972 |
Glucose tolerance tests in the perinatal rats.
Topics: Animals; Animals, Newborn; Cesarean Section; Diabetes Mellitus, Experimental; Female; Glucagon; Glucose Tolerance Test; Insulin; Insulin Secretion; Pancreatectomy; Pregnancy; Pregnancy in Diabetics; Rats; Rats, Inbred Strains | 1972 |
Effect of ecdysterone on hyperglycemia in experimental animals.
Topics: Alloxan; Animals; Carbon Isotopes; Cholestanes; Diabetes Mellitus, Experimental; Drug Antagonism; Glucagon; Glucose; Hyperglycemia; Insulin Antibodies; Invertebrate Hormones; Liver Glycogen; Male; Mice; Plant Growth Regulators; Protein Biosynthesis; Rats | 1971 |
[Pyruvate carboxylase activity and glucose production in isolated perfused rat liver].
Topics: Animals; Dexamethasone; Diabetes Mellitus, Experimental; Glucagon; Gluconeogenesis; Hydrocortisone; In Vitro Techniques; Kidney; Ligases; Liver; Perfusion; Pyruvates; Rats | 1966 |
Hyperglycemic response to massive doses of commercial insulin.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucagon; Hyperglycemia; Insulin; Insulin Resistance; Male; Rabbits | 1970 |
[Glucose regulation].
Topics: Animals; Blood Glucose; Catecholamines; Diabetes Mellitus; Diabetes Mellitus, Experimental; Female; Food; Glucagon; Glucose; Glucose Tolerance Test; Glycosuria; Growth Hormone; Hyperglycemia; Insulin; Intestinal Absorption; Liver; Liver Glycogen; Male; Rats; Starvation | 1970 |
Exercise, lactate, hormones, and gold thioglucose lesions of the hypothalamus of diabetic mice.
Topics: Adipose Tissue; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Epinephrine; Feeding Behavior; Glucagon; Glucose; Gold; Hypothalamus; Injections, Intraperitoneal; Injections, Intravenous; Insulin; Lactates; Mice; Norepinephrine; Physical Exertion; Tissue Extracts | 1971 |
Regulation of glucose-phosphorylating enzymes.
Topics: Animals; Chromatography, Ion Exchange; Dactinomycin; Diabetes Mellitus, Experimental; Dietary Carbohydrates; Enzyme Induction; Enzyme Repression; Glucagon; Glucocorticoids; Glucokinase; Glucose; Growth Hormone; Immune Sera; Insulin; Isoenzymes; Kinetics; Liver; Rats | 1967 |
Some aspects on the blood glucose regulation and the glutathione content of the non-diabetic adult chinese hamster, Cricetulus griseus.
Topics: Alloxan; Animals; Blood Glucose; Cobalt; Cricetinae; Diabetes Mellitus, Experimental; Epinephrine; Erythrocytes; Glucagon; Glucose Tolerance Test; Glutathione; Growth Hormone; Insulin; Kidney; Liver; Myocardium; Pancreas | 1967 |
Role of adenosine 3',5'-monophosphate in the effects of insulin and anti-insulin serum on liver metabolism.
Topics: Adenine Nucleotides; Animals; Blood Glucose; Carbon Isotopes; Citrates; Diabetes Mellitus, Experimental; Epinephrine; Fatty Acids, Nonesterified; Glucagon; Glucose; Guinea Pigs; Immune Sera; In Vitro Techniques; Insulin; Lactates; Liver; Liver Glycogen; Male; Myocardium; Perfusion; Potassium; Rats; Urea | 1968 |
Hepatic lipid metabolism in experimental diabetes. V. The effect of concentration of oleate on metabolism of triglycerides and on ketogenesis.
Topics: Animals; Cholesterol; Diabetes Mellitus, Experimental; Esters; Fatty Acids, Nonesterified; Glucagon; In Vitro Techniques; Ketone Bodies; Liver; Male; Oleic Acids; Perfusion; Phospholipids; Rats; Serum Albumin, Bovine; Stimulation, Chemical; Time Factors; Triglycerides | 1969 |
Pancreatic hormones and hepatic methionine adenosyltransferase in the rat.
Topics: Adenosine Triphosphate; Alloxan; Animals; Blood Glucose; Cycloheximide; Dactinomycin; Diabetes Mellitus, Experimental; Enzyme Induction; Female; Glucagon; Insulin; Liver; Male; Methionine; Rats; Stimulation, Chemical; Transferases; Triamcinolone | 1969 |
The pentose phosphate pathway of glucose metabolism. Hormonal and dietary control of the oxidative nd non-oxidative reactions and related enzymes of the cycle in adipose tissue.
Topics: Adipose Tissue; Adrenalectomy; Animals; Cortisone; Diabetes Mellitus, Experimental; Diet; Dietary Carbohydrates; Dietary Fats; Glucagon; Glucose; Glucosephosphate Dehydrogenase; Insulin; Isomerases; Liver; Male; Pentosephosphates; Phosphogluconate Dehydrogenase; Rats; Starvation; Thyroidectomy; Transferases | 1969 |
[Effect of sulfur-containing compounds on experimental diabetes. II. Correlation between blood sugar level and variation in acid-soluble SH and S-S group in blood during insulin secretion or insulin action].
Topics: Animals; Blood Glucose; Cystine; Diabetes Mellitus, Experimental; Epinephrine; Glucagon; Glucose; Glutathione; Glycine; Insulin; Insulin Antagonists; Insulin Secretion; Male; Rabbits; Sulfhydryl Compounds; Sulfur; Time Factors | 1969 |
Amethod for measuring deviations from equilibrium of the glucose anomers in blood.
Topics: Animals; Blood Chemical Analysis; Blood Glucose; Chemical Phenomena; Chemistry; Colorimetry; Diabetes Mellitus, Experimental; Dogs; Epinephrine; Glucagon; Glucose Oxidase; In Vitro Techniques; Insulin; Sodium Chloride; Sodium Hydroxide | 1965 |
Hormonal control of enzymes participating in gluconeogenesis and lipogenesis.
Topics: Alcohol Oxidoreductases; Animals; Dactinomycin; Diabetes Mellitus, Experimental; Fasting; Fatty Acids; Glucagon; Gluconeogenesis; Glucose; Heptoses; Hexoses; Hydrocortisone; Liver; Phosphotransferases; Rats | 1965 |
Hepatic glutamic dehydrogenase in diabetes and following excess glucagon.
Topics: Adrenalectomy; Animals; Diabetes Mellitus, Experimental; Glucagon; Glutamate Dehydrogenase; Hydrocortisone; In Vitro Techniques; Insulin, Long-Acting; Liver; Rats | 1966 |
Gluconeogenesis in the perfused liver. The effects of fasting, alloxan diabetes, glucagon, epinephrine, adenosine 3',5'-monophosphate and insulin.
Topics: Adenine Nucleotides; Animals; Diabetes Mellitus, Experimental; Epinephrine; Fasting; Glucagon; Gluconeogenesis; Glucose; Guinea Pigs; In Vitro Techniques; Insulin; Liver; Perfusion; Rats | 1966 |
Glucagon-like immunoreactants in extracts of the rat hypothalamus.
Topics: Animals; Body Weight; Chromatography, Gel; Diabetes Mellitus, Experimental; Fasting; Glucagon-Like Peptides; Hypothalamus; Male; Molecular Weight; Peptides; Rats; Rats, Inbred Strains | 1982 |
Preserved GLP-I effects on glycogen synthase a activity and glucose metabolism in isolated hepatocytes and skeletal muscle from diabetic rats.
Topics: Animals; Animals, Newborn; Carbon Radioisotopes; Cells, Cultured; Cohort Studies; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Disease Models, Animal; Glucagon-Like Peptides; Glucose; Glycogen Synthase; Insulin; Liver; Muscle, Skeletal; Pancreatic Hormones; Peptides; Phosphorylases; Rats; Rats, Wistar | 1997 |