glucagon has been researched along with Adenoma, beta-Cell in 180 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 61 (33.89) | 18.7374 |
| 1990's | 77 (42.78) | 18.2507 |
| 2000's | 26 (14.44) | 29.6817 |
| 2010's | 12 (6.67) | 24.3611 |
| 2020's | 4 (2.22) | 2.80 |
| Authors | Studies |
|---|---|
| Midkiff, CC; Saied, AA; Shroyer, MN; Taylor, JM | 1 |
| de Herder, WW; Klöppel, G | 1 |
| Bloch, CP; Harris, ME; Weatherton, L | 1 |
| Miyazaki, JI; Miyazaki, S; Sasaki, K; Tashiro, F; Tsuchiya, T | 1 |
| Jung, H; Kim, MK; Kim, TK; Kim, TN; Kwon, MJ; Lee, E; Lee, SH; Park, JH; Rhee, BD; Shin, HM | 1 |
| Agin, A; Charrie, A; Chikh, K; Tabarin, A; Vezzosi, D | 1 |
| Bennett, KR; Gaunt, MC; Parker, DL | 1 |
| Deng, T; Fang, N; Fang, Q; Hua, Z; Liu, H; Lou, J; Peng, L; Wang, P; Wang, Z; Xu, S; You, J; Zhang, W | 1 |
| Caldwell, D; Chen, Q; Coughlan, MC; Florian, M; Fu, A; Jin, X; Lalande, M; Laziyan, M; Mailloux, R; Patry, D; Petrov, I; Wang, GS; Willmore, W; Yan, J | 1 |
| Fujimori, N; Igarashi, H; Ito, T; Jensen, RT; Kawabe, K; Lee, L; Oda, Y; Tachibana, Y; Takayanagi, R; Ueda, K | 1 |
| Bertolino, P; Bonnavion, R; Calender, A; Carreira, C; Herrera, PL; Lu, J; Seigne, C; Zhang, CX | 1 |
| Adem, A; Hewitt, SM; Libutti, SK; Pechhold, K; Shen, HC; Wilson, A; Ylaya, K | 1 |
| Batcher, E; Gianoukakis, AG; Madaj, P | 1 |
| Felício, JS; Kalinin, L; Liberman, B; Machado, MC; Martins, CL; Mileo, KB; Nery, M; Semer, M | 1 |
| Menger, MD; Müller, I; Rössler, OG; Thiel, G; Wittig, C | 1 |
| Isogawa, A; Kishi, S; Mori, M; Sakamoto, K; Shiba, T | 1 |
| Filipsson, K; Jing, XJ; Reimer, MK; Renström, E; Rosengren, A | 1 |
| Bousquet, C; Hui, H; Perfetti, R; Yu, R | 1 |
| Mentlein, R; Stark, A | 1 |
| Hui, H; Nourparvar, A; Perfetti, R; Zhao, X | 1 |
| DE LOOSE, F; DEDULLEN, G; ELEWAUT, A | 1 |
| BECK-CHRISTIANSEN, O | 1 |
| MARKS, V; MARRACK, D; ROSE, FC | 1 |
| Tomita, T | 1 |
| Arita, Y; Ito, T | 1 |
| Clynes, M; Gammell, P; O'Driscoll, L | 1 |
| Islam, KB; Islam, MS; Mirzaei, Z; Rahman, SA | 1 |
| Keller, U; Perren, A; Pfammatter, T; Schmid, C; Spinas, GA; Wiesli, P | 1 |
| Bollheimer, LC; Buettner, R; Ottinger, I; Rockmann, F; Schölmerich, J; Wrede, CE | 1 |
| Mol, JA; Rijnberk, A; Robben, JH; van den Brom, WE; van Haeften, TW | 1 |
| Bermano, G; Docherty, K; Durward, E; Hay, CW; Sinclair, EM; Tadayyon, M | 1 |
| Hirata, Y; Ishizawa, M; Nishida, K; Sugiyama, T; Takada, Y; Takanishi, K; Tsujino, M | 1 |
| Couvelard, A; Fregeville, A; Paradis, V; Vilgrain, V; Warshauer, DM | 1 |
| Adukauskiene, D; Blauzdyte, J | 1 |
| Kawaoi, A; Koyama, H; Kumae, S; Nakamura, M; Ono, J; Takaki, R; Yokogawa, Y | 1 |
| Függer, R; Funovics, J; Schulz, F; Ulrich, W; Zöch, G | 1 |
| Chick, WL; Hales, CN; Hutton, JC; Naber, SP; Sopwith, AM | 1 |
| Neumayr, A | 1 |
| Bauer, GE; Dixit, PK; Johnson, DE; Michels, JE | 1 |
| Ferguson, DC; Hoenig, M; Matschinsky, FM | 2 |
| Christova, T; Daskalova, R; Georgiev, C; Sivtchev, S; Zafirova, M | 1 |
| Hedeskov, CJ; Knudsen, P; Kofod, H; Lernmark, A | 1 |
| Stacpoole, PW | 1 |
| Ericsson, M; Holst, J; Ingemansson, S; Järhult, J | 1 |
| Barczyk, J; Kinalska, I; Puchalski, Z; Triebling, A | 1 |
| Kobayashi, T; Nihei, J; Ohneda, A | 1 |
| Cowan, RG; McCann, JP; Reimers, TJ; Ross, MW | 1 |
| Kobayashi, T; Nihei, J; Ohneda, A; Sakai, T | 2 |
| Atsmon, A; Blum, I; Doron, M; Lahav, M; Laron, Z; Rusecki, Y | 1 |
| Andreani, D; Lala, A; Leonetti, F; Libianchi, S; Mauceri, M; Tamburrano, G | 1 |
| Berger, M; Tsotsalas, M | 1 |
| Berchtold, P; Berger, M; Bordi, C; Cüppers, HJ; Gries, FA; Münterfering, H; Orci, L; Sailer, R; Zimmermann, H | 1 |
| Bloom, SR; Polak, JM; Wood, SM | 1 |
| Hehmke, B; Kohnert, KD; Ulrich, FE; Woltanski, KP; Zühlke, H | 1 |
| Kajikawa, K; Katsuda, S; Konishi, K; Miwa, K; Nakanishi, I; Yonemura, Y | 1 |
| Bonser, AM; Garcia-Webb, P | 1 |
| Bode, HP; Göke, B; Göke, R; Lankat-Buttgereit, B; van Eyll, B | 1 |
| Habener, JF; Holz, GG; Leech, CA | 1 |
| Egan, JM; Montrose-Rafizadeh, C; Nadiv, O; Raygada, M; Roth, J; Wang, Y | 1 |
| Bode, HP; Fehmann, HC; Göke, B; Göke, R; Lankat-Buttgereit, B; Volz, A | 1 |
| Avogaro, A; del Prato, S; Dorella, M; Marescotti, MC; Riccio, A; Tiengo, A; Vigili de Kreutzenberg, S | 1 |
| Göke, B; Göke, R; McGregor, GP | 1 |
| Bokvist, K; Dissing, S; Frøkjaer-Jensen, J; Gromada, J; Renström, E; Rorsman, P; Wulff, BS | 1 |
| Fehmann, HC; Gherzi, R; Göke, B; Ponassi, M; Volz, A | 1 |
| Araki, E; Isami, S; Jinnouchi, H; Kisanuki, K; Kishikawa, H; Miyamura, N; Shichiri, M; Shirotani, T; Uehara, M; Ura, S | 1 |
| Biswas, C; Brady, EJ; Conti, M; Cullinan, CA; Hayes, NS; Leibowitz, MD; Manganiello, VC; Saperstein, R; Wang, LH; Zafian, PT | 1 |
| Funakoshi, A; Iwamoto, N; Matsuoka, Y; Shima, K; Tateishi, K; Yasunami, Y | 1 |
| Kuwajima, M; Matsumura, T; Matsuzawa, Y; Mineo, I; Namba, M; Shingu, R | 1 |
| Eckart, K; Fölsch, UR; Gallwitz, B; Morys-Wortmann, C; Paetzold, G; Schmidt, WE; Witt, M; Zimmermann, B | 1 |
| Briata, P; Fehmann, HC; Gherzi, R; Göke, B | 1 |
| Egan, JM; Montrose-Rafizadeh, C; Roth, J | 1 |
| D'Alessandro, B; Esposito, D; Esposito, V; Lo Iudice, G; Rispoli, C; Verrillo, A | 1 |
| Aunis, D; Bader, MF; Bargsten, G; Cetin, Y; Galindo, E; Grube, D; Jörns, A | 1 |
| Challis, DR; Davies, PF; McArdle, JP; Shepherd, JJ; Teh, BT; Wilkinson, S | 1 |
| Fehmann, HC; Göke, B; Göke, R; Jiang, J; Lankat-Buttgereit, B; Stöckmann, F | 1 |
| Kawai, K; Ohashi, S; Suzuki, S; Watanabe, Y; Yamashita, K; Yokota, C | 1 |
| Buettger, C; Epstein, AJ; Hang, TL; Matschinsky, FM; Ronner, P | 1 |
| O'Brien, PC; O'Brien, T; Service, FJ | 1 |
| Atillasoy, EJ; Burtis, WJ; Gaich, G; Ganz, MB; Orloff, JJ; Stewart, AF | 1 |
| Brunner, HR; Grouzmann, E; Nicod, P; Thompson, N; Waeber, B; Waeber, G | 1 |
| Eng, J; Fehmann, HC; Göke, B; Göke, R; Krause, M; Linn, T; Schmidt, H | 1 |
| Fujikawa, J; Imamura, M; Imura, H; Inoue, K; Kadowaki, S; Kojima, H; Seino, Y; Yamamoto, T | 1 |
| Andersson, DE; Eriksson, B; Stridsberg, M; Svartberg, J; Wilander, E | 1 |
| Abrahamsen, N; Froguel, P; Hager, J; Hansen, LH; Jelinek, L; Kindsvogel, W; Nishimura, E | 1 |
| Dissing, S; Gromada, J; Rorsman, P | 1 |
| Fölsch, UR; Gallwitz, B; Morys-Wortmann, C; Schmidt, WE; Witt, M | 1 |
| O'Dorisio, TM; Thompson, CS; Woltering, EA | 1 |
| Boissard, C; Breant, B; Marie, JC; Rosselin, G; Skoglund, G | 1 |
| Thorens, B; Widmann, C | 1 |
| Göke, B; Göke, R; Steffen, H | 1 |
| Ahrén, B; Karlsson, S; Simonsson, E | 1 |
| Dolci, W; Thorens, B; Widmann, C | 1 |
| Adler, G; Fussgänger, RD; Jehle, D; Jehle, PM | 1 |
| Fehmann, HC; Göke, B; Jiang, J; Pitt, D; Schweinfurth, J | 1 |
| Fatourechi, V; Kvols, LK; Wermers, RA | 1 |
| Jensen, CH; Larsson, LI; Teisner, B; Tornehave, D | 1 |
| Furmanenko, ED; Kozhara, SP; Lifshits, IuZ; Usenko, AIu | 1 |
| Deeg, MA; Verchere, CB | 1 |
| Fujisawa, T; Hamada, Y; Ikegami, H; Nakagawa, Y; Ogihara, T; Takekawa, K; Ueda, H; Yamato, E | 1 |
| Andrews, GA; Chard-Bergstrom, C; Myers, NC | 1 |
| Göke, B; Göke, R; Hupe-Sodmann, K; McGregor, GP; Thole, HH; Voigt, K; Zimmermann, B | 1 |
| Göke, B; Lankat-Buttgereit, B | 1 |
| Bishof-Delaloye, A; Centeno, G; Chaubert, P; Francke, ML; Gomez, F; Haefliger, JA; Nicod, P; Scherrer, U; Temler, E; Waeber, G | 1 |
| Birkeland, K; Jorde, R; Revhaug, A; Sager, G; Sundsfjord, J; Trovik, TS; Vea, H | 1 |
| Kostenko, AA | 1 |
| Totsuka, Y | 1 |
| Compton, DS; Davis, HR; France, CF; Graziano, MP; Hoos, LM; Mullins, DE; Pines, JM; Strader, CD; Sybertz, EJ; Van Heek, M | 1 |
| Hoff, AO; Vassilopoulou-Sellin, R | 1 |
| Bernstein, IL; D'Alessio, D; Eng, J; Seeley, RJ; Thiele, TE; van Dijk, G; Woods, SC | 1 |
| Galehshahi, FS; Göke, B; Lankat-Buttgereit, B | 1 |
| Bloom, SR; Ghatei, MA; Hurley, JD; Karlsen, AE; Kulkarni, RN; Morgan, DG; Smith, DM; Wang, RM; Wang, ZL | 1 |
| Mamujee, SN; Sun, AM; Vacek, I; Wheeler, MB; Zhou, D | 1 |
| Cahill, CM; Doyle, ME; Egan, JM; Piñeyro, MA; Wang, X; Zhou, J | 1 |
| Gallwitz, B; Mentlein, R; Morys-Wortmann, C; Ropeter, T; Schmidt, WE; Siegel, EG | 1 |
| Kobayashi, T; Ogawa, S; Yanagi, H; Yura, T | 1 |
| Ebinger, M; Fehmann, HC; Fussgaenger, RD; Jehle, DR; Jehle, PM | 1 |
| Aust, G; Nguyen, TB; Scherbaum, WA; Seissler, J; Steinbrenner, H | 1 |
| Holz, GG; Hussain, MA; Skoglund, G | 1 |
| Hori, S; Kondo, H; Nakagaki, I; Sasaki, S | 1 |
| Hagenfeldt, KA; Ishihara, H; Maechler, P; Philippe, J; Ritz-Laser, B; Wang, H; Wollheim, CB | 1 |
| Chepurny, OG; Holz, GG | 1 |
| Bhagroo, NV; Brelje, TC; Sorenson, RL; Stout, LE; Svensson, AM | 1 |
| Breslin, MB; Lan, MS; Zhu, M | 1 |
| Béhé, M; Behr, TM; Fischer, M; Fritsch, HW; Göke, B; Gotthardt, M; Holz, JB; Joseph, K; Jungclas, H; Naeher, I | 1 |
| Fehmann, HC; Habener, JF | 3 |
| Göke, B; Göke, R; Oltmer, B; Sheikh, SP | 1 |
| Bataille, D; Demirpence, E; Gros, L; Jarrousse, C; Kervran, A | 1 |
| Itoh, H; Komatsu, R; Kono, N; Matsumura, T; Matsuyama, T; Matsuzawa, Y; Namba, M; Oda, Y; Tanaka, M; Watanabe, N | 1 |
| Maeda, S; Nakamura, T; Satonaka, K | 1 |
| Stehouwer, C | 1 |
| Besch, W; Hehmke, B; Köhler, E; Lucke, S; Schlosser, M; Witt, S; Ziegler, B; Ziegler, M | 1 |
| Bataille, D; Estival, A; Jarrousse, C; Le Quellec, A; Martinez, J; Pradayrol, L; Sladeczek, F; Tani, T | 1 |
| Chafitz, JA; Habener, JF; Knepel, W; Vallejo, M | 1 |
| Brubaker, PL; Campos, RV; Drucker, DJ; Stobie, KM; Wang, C | 1 |
| Creutzfeldt, W; Nauck, MA; Siegel, EG | 1 |
| Betsholtz, C; Madsen, OD; Michelsen, B; Nielsen, JH; Nishi, M; Steiner, DF; Westermark, P | 1 |
| Flatt, PR; Hampton, SM; Marks, V; Shiber, O | 1 |
| Broderick, CL; Brooke, GS; DiMarchi, RD; Gold, G | 1 |
| Gefel, D; Habener, J; Hendrick, GK; Mojsov, S; Weir, GC | 1 |
| Habener, JF; Jepeal, L; Knepel, W | 1 |
| Arnold, R; Göke, B; Göke, R; Richter, G | 1 |
| Danoff, A; Fleischer, N; Pasmantier, R; Schubart, UK | 1 |
| Bertrand, J; Demidem, A; Durand, A; Haftek, M; Thivolet, CH | 1 |
| Guillemin, R; Leppäluoto, J; Ling, N; Ueno, N; Ying, SY; Zeytin, F | 1 |
| Fischer, HR; Hackeng, WH; Lems, WF; Naafs, MA; Stehouwer, CD | 1 |
| Cole, T; Conlon, JM; Göke, R | 1 |
| Arnold, R; Fehmann, HC; Göke, B; Göke, R; Haus, E; Richter, G; Trautmann, ME | 1 |
| Arnold, R; Göke, B; Göke, R; Richter, G; Trautmann, M | 1 |
| Funakoshi, A; Ishii, H; Jimi, A; Konomi, K; Miyazaki, K; Nawata, H | 1 |
| Bani Sacchi, T; Bani, D; Biliotti, G | 1 |
| Fehmann, HC; Göke, B; Göke, R; Richter, G; Trautmann, M | 1 |
| Nielsen, JH; Orskov, C | 1 |
| Conlon, JM; Göke, R | 1 |
| Asano, T; Okeda, T; Ono, J; Takaki, R; Yamaguchi, K | 1 |
| Ho, PW; Pun, KK; Tam, CF; Wang, C; Young, RT | 1 |
| Bloom, SR; Williams, SJ; Wynick, D | 1 |
| Amblard, P; Béani, JC; Benhamou, PY; Boizel, R; Reymond, JL | 1 |
| Dubitskiĭ, AE; Furmanenko, ED; Kozhara, SP | 1 |
| Goudswaard, WB; Houthoff, HJ; Koudstaal, J; Zwierstra, RP | 1 |
| Hamaguchi, K; Hiraoka, T; Kumae, S; Nakamura, M; Ono, J; Takaki, R; Uchida, S; Yamaguchi, K; Yokogawa, Y | 1 |
| Bailey, CJ; Flatt, PR; Marks, V; Powell, CJ; Swanston-Flatt, SK; Tan, KS | 1 |
| Chick, WL; Habener, JF; Philippe, J | 1 |
| Flatt, PR; Marks, V; Swanston-Flatt, SK; Tan, KS; Webster, JD | 1 |
| Schonbrunn, A; Sullivan, SJ | 1 |
| Longnecker, SM | 1 |
| Comi, R; Drucker, DJ; Habener, JF; Mojsov, S; Philippe, J; Powers, AC | 1 |
| Hiraoka, T; Murata, E; Tashiro, S | 1 |
| Bhathena, SJ; Korman, LY; Oie, HK; Recant, L; Voyles, NR | 1 |
| Carlo Stella, C; De Caro, L; Ghizzi, A; Gorini, M | 1 |
| Chiba, T; Chihara, K; Fujita, T; Kinoshita, Y; Kondo, T; Kotoura, Y; Nonaka, H; Suzuki, S; Yamamura, T | 1 |
| Andreu, M; Greaves, P; Spencer, AJ | 1 |
| Kumae, S; Ono, J; Sato, Y; Takaki, R | 1 |
| Bailey, CJ; Conlon, JM; Deacon, CF; Flatt, PR | 1 |
| Kurihara, Y | 1 |
| Drucker, DJ; Mojsov, S; Philippe, J | 1 |
| Fehmann, HC; Göke, B; Strowski, M | 1 |
9 review(s) available for glucagon and Adenoma, beta-Cell
| Article | Year |
|---|---|
One hundred years after the discovery of insulin and glucagon: the history of tumors and hyperplasias that hypersecrete these hormones.
Topics: Animals; Dogs; Glucagon; Hyperplasia; Insulin; Insulinoma; Pancreatic Neoplasms | 2023 |
Pancreatic neuroendocrine tumors.
Topics: Gastrinoma; Gastrins; Glucagon; Glucagonoma; Hormones; Humans; Hypoglycemia; Insulinoma; Neuroendocrine Tumors; Pancreatic Neoplasms; Somatostatinoma; Vasoactive Intestinal Peptide; Vipoma | 2011 |
[Diagnosis and treatment of insulinoma].
Topics: Antineoplastic Agents; Blood Glucose; Chemoembolization, Therapeutic; Diazoxide; Fasting; Glucagon; Humans; Insulinoma; Magnetic Resonance Imaging; Maleic Anhydrides; Multiple Endocrine Neoplasia Type 1; Pancreatic Neoplasms; Polystyrenes; Somatostatin; Tomography, X-Ray Computed; Zinostatin | 2004 |
[Causes, diagnosis, and treatment of hypoglycemia].
Topics: Adolescent; Adult; Aged; Algorithms; Anti-Inflammatory Agents; Blood Glucose; Child; Diabetes Complications; Diagnosis, Differential; Female; Glucagon; Glucose; Glucose Tolerance Test; Homeostasis; Humans; Hydrocortisone; Hypoglycemia; Insulin; Insulin Secretion; Insulinoma; Male; Middle Aged; Pancreatic Neoplasms | 2006 |
The glucagonoma syndrome: clinical features, diagnosis, and treatment.
Topics: Adenoma, Islet Cell; Adult; Amino Acids; Diagnosis, Differential; Female; Glucagon; Glucagonoma; Humans; Hyperglycemia; Insulinoma; Male; Middle Aged; Pancreatic Neoplasms; Paraneoplastic Endocrine Syndromes; Skin | 1981 |
Gut hormone secreting tumours.
Topics: Adenoma, Islet Cell; Bombesin; Bronchial Neoplasms; C-Peptide; Carcinoma, Small Cell; Diagnosis, Differential; Endocrine System Diseases; Erythema; Gastrointestinal Hormones; Glucagon; Glucagonoma; Humans; Insulin; Insulin Secretion; Insulinoma; Male; Neoplasms; Neurotensin; Pancreatic Hormones; Pancreatic Neoplasms; Pancreatic Polypeptide; Somatostatinoma; Vasoactive Intestinal Peptide; Zollinger-Ellison Syndrome | 1983 |
C-peptide measurement and its clinical usefulness: a review.
Topics: Adolescent; Adult; Aged; Blood Glucose; C-Peptide; Diabetes Mellitus; Diabetes Mellitus, Type 1; Female; Glucagon; Humans; Hypoglycemia; Infant, Newborn; Insulin; Insulinoma; Islets of Langerhans; Kidney Function Tests; Middle Aged; Peptides; Radioimmunoassay | 1981 |
Tumour-induced hypoglycaemia in a patient with insulin-dependent diabetes mellitus.
Topics: Adult; Amyloid; Diabetes Mellitus, Type 1; Diagnosis, Differential; Fatal Outcome; Female; Glucagon; Humans; Hypoglycemia; Insulin; Insulinoma; Islet Amyloid Polypeptide; Pancreatic Neoplasms | 1996 |
[Glucagonoma and somatostatinoma].
Topics: Glucagon; Glucagonoma; Glucose; Humans; Insulin; Insulin Secretion; Insulinoma; Pancreatic Neoplasms; Somatostatinoma | 1998 |
2 trial(s) available for glucagon and Adenoma, beta-Cell
| Article | Year |
|---|---|
Effect of octreotide on plasma concentrations of glucose, insulin, glucagon, growth hormone, and cortisol in healthy dogs and dogs with insulinoma.
Topics: Animals; Blood Glucose; Dog Diseases; Dogs; Glucagon; Growth Hormone; Health; Hydrocortisone; Insulin; Insulinoma; Octreotide | 2006 |
Calcium reverses octreotide inhibition of insulin and glucagon levels in patients with insulinoma and glucagonoma.
Topics: Antineoplastic Agents, Hormonal; Calcium; Glucagon; Glucagonoma; Humans; Hypoglycemic Agents; Infusions, Intravenous; Insulin; Insulinoma; Octreotide; Pancreatic Neoplasms; Secretin; Tolbutamide | 1996 |
169 other study(ies) available for glucagon and Adenoma, beta-Cell
| Article | Year |
|---|---|
Functional Insulinomas in a Rhesus Macaque (Macaca mulatta).
Topics: Animals; Chromogranin A; Female; Gastrins; Glucagon; Glucose; Hypoglycemic Agents; Insulinoma; Insulins; Macaca mulatta; Pancreatic Neoplasms; Pancreatic Polypeptide; Somatostatin; Sugars; Synaptophysin | 2022 |
Glucagon therapy in canines with an insulinoma: A retrospective descriptive study of 11 dogs.
Topics: Animals; Blood Glucose; Dog Diseases; Dogs; Euthanasia, Animal; Glucagon; Insulin; Insulinoma; Pancreatic Neoplasms; Retrospective Studies | 2020 |
Establishment of a long-term stable β-cell line and its application to analyze the effect of Gcg expression on insulin secretion.
Topics: Animals; Female; Glucagon; Glucagon-Like Peptide-1 Receptor; Insulin Secretion; Insulin-Secreting Cells; Insulinoma; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Knockout; Pancreatic Neoplasms | 2021 |
Comparison of pancreatic beta cells and alpha cells under hyperglycemia: Inverse coupling in pAkt-FoxO1.
Topics: Adenoma; Animals; Cell Line, Tumor; Cell Proliferation; Diabetes Mellitus, Type 2; Forkhead Box Protein O1; Glucagon; Glucagon-Secreting Cells; Glucose; Hydrogen Peroxide; Hyperglycemia; Insulin; Insulin Secretion; Insulin-Secreting Cells; Insulinoma; Mice; Pancreatic Neoplasms; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt | 2017 |
Fast test: clinical practice and interpretation.
Topics: Blood Glucose; Decision Trees; Diagnosis, Differential; Diagnostic Techniques, Endocrine; Fasting; Glucagon; Glucose Tolerance Test; Humans; Hypoglycemia; Insulinoma; Pancreatic Neoplasms; Professional Practice; Proinsulin | 2013 |
Constant rate infusion of glucagon as an emergency treatment for hypoglycemia in a domestic ferret (Mustela putorius furo).
Topics: Animals; Blood Glucose; Female; Ferrets; Glucagon; Hypoglycemia; Insulinoma | 2015 |
Colocalization of insulin and glucagon in insulinoma cells and developing pancreatic endocrine cells.
Topics: Animals; Cell Line; Endocrine Cells; Glucagon; Insulin; Insulinoma; Mice; Pancreas; Pancreatic Neoplasms; Rats; Subcellular Fractions; Tissue Distribution | 2015 |
A Northern contaminant mixture impairs pancreas function in obese and lean JCR rats and inhibits insulin secretion in MIN6 cells.
Topics: Alcohol Drinking; Animals; Cell Death; Cell Line, Tumor; Complex Mixtures; Diabetes Mellitus; Disease Models, Animal; Dose-Response Relationship, Drug; Environmental Pollutants; Glucagon; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Male; Mice; Mitochondria; Obesity; Oxidative Stress; Pancreatic Neoplasms; Rats; Risk Assessment; Thinness | 2015 |
Diagnostic Performance of 48-Hour Fasting Test and Insulin Surrogates in Patients With Suspected Insulinoma.
Topics: 3-Hydroxybutyric Acid; Adult; Aged; Blood Glucose; C-Peptide; Fasting; Fatty Acids, Nonesterified; Female; Glucagon; Humans; Insulin; Insulinoma; Male; Middle Aged; Pancreatic Neoplasms; Retrospective Studies; Sensitivity and Specificity; Time Factors | 2017 |
Alpha cell-specific Men1 ablation triggers the transdifferentiation of glucagon-expressing cells and insulinoma development.
Topics: Age Factors; Aging; Animals; Biomarkers; Cell Fusion; Cell Lineage; Cell Proliferation; Cell Transdifferentiation; Cell Transformation, Neoplastic; Gene Deletion; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genotype; Glucagon; Glucagon-Secreting Cells; Glucagonoma; Insulin; Insulin-Secreting Cells; Insulinoma; Mice; Mice, Knockout; Pancreatic Neoplasms; Phenotype; Proto-Oncogene Proteins; Transcription Factors | 2010 |
Multiple endocrine neoplasia type 1 deletion in pancreatic alpha-cells leads to development of insulinomas in mice.
Topics: Animals; Cells, Cultured; Gene Deletion; Gene Knockdown Techniques; Glucagon; Glucagon-Secreting Cells; Insulinoma; Mice; Mice, Transgenic; Organ Specificity; Pancreatic Neoplasms; Proto-Oncogene Proteins | 2010 |
Glucagon test in insulinoma: Is it useful?
Topics: Adult; Aged; Blood Glucose; Female; Glucagon; Hormones; Humans; Hyperinsulinism; Hypoglycemia; Insulin; Insulinoma; Male; Middle Aged; Pancreatic Neoplasms; Radioimmunoassay; Young Adult | 2012 |
Critical role of Egr transcription factors in regulating insulin biosynthesis, blood glucose homeostasis, and islet size.
Topics: Animals; Blood Glucose; Early Growth Response Transcription Factors; Gene Transfer Techniques; Glucagon; Glucose; Glucose Tolerance Test; Homeodomain Proteins; Homeostasis; Insulin; Insulin-Secreting Cells; Insulinoma; Islets of Langerhans; Mice; Mice, Transgenic; Mutation; Rats; Somatostatin; Transforming Growth Factor beta; Transgenes | 2012 |
Asymptomatic insulinoma: a case report and autopsy series.
Topics: Autopsy; Calcium Gluconate; Diagnosis, Differential; Early Detection of Cancer; Female; Glucagon; Glucagonoma; Humans; Hypoglycemia; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Middle Aged; Pancreas; Pancreatic Neoplasms; Retrospective Studies; Tomography, X-Ray Computed | 2012 |
Glucose dependence of insulinotropic actions of pituitary adenylate cyclase-activating polypeptide in insulin-secreting INS-1 cells.
Topics: Action Potentials; Animals; Calcium; Calcium Channels; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Electrophysiology; Exocytosis; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Neuropeptides; Neurotransmitter Agents; Pancreatic Neoplasms; Patch-Clamp Techniques; Peptide Fragments; Pituitary Adenylate Cyclase-Activating Polypeptide; Protein Precursors; Rats; Tumor Cells, Cultured | 2002 |
Transfection of pancreatic-derived beta-cells with a minigene encoding for human glucagon-like peptide-1 regulates glucose-dependent insulin synthesis and secretion.
Topics: Animals; Blotting, Northern; Blotting, Western; Cyclic AMP; Cytomegalovirus; Fluorescent Antibody Technique; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Mice; Microscopy, Fluorescence; Pancreatic Neoplasms; Peptide Fragments; Proglucagon; Promoter Regions, Genetic; Protein Precursors; RNA, Messenger; Signal Transduction; Transfection; Tumor Cells, Cultured | 2002 |
Somatostatin inhibits glucagon-like peptide-1-induced insulin secretion and proliferation of RINm5F insulinoma cells.
Topics: Animals; Cell Division; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Drug Interactions; Glucagon; Glucagon-Like Peptide 1; Insulin; Insulin Secretion; Insulinoma; Pancreatic Neoplasms; Peptide Fragments; Protein Precursors; Rats; Somatostatin; Transcription Factors; Tumor Cells, Cultured | 2002 |
Glucagon-like peptide-1 inhibits apoptosis of insulin-secreting cells via a cyclic 5'-adenosine monophosphate-dependent protein kinase A- and a phosphatidylinositol 3-kinase-dependent pathway.
Topics: Animals; Apoptosis; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; DNA; Glucagon; Glucagon-Like Peptide 1; Hydrogen Peroxide; Insulinoma; Islets of Langerhans; Mice; Oxidants; Peptide Fragments; Phosphatidylinositol 3-Kinases; Poly(ADP-ribose) Polymerases; Protein Precursors; Signal Transduction; Tumor Cells, Cultured | 2003 |
[Hypoglycemia caused by beta-cell adenoma of the pancreas. Use of glucagon].
Topics: Adenoma, Islet Cell; Glucagon; Humans; Hypoglycemia; Insulinoma; Pancreas; Pancreatic Diseases; Pancreatic Neoplasms | 1963 |
METASTASIZING INSULINOMA TREATED WITH GLUCAGON.
Topics: Adenoma, Islet Cell; Glucagon; Glucose; Humans; Hyperinsulinism; Insulin Coma; Insulinoma; Neoplasm Metastasis; Neoplasms; Pancreatic Neoplasms | 1964 |
Glucagon and tolbutamide tests in the recognition of insulinomas.
Topics: Adenoma, Islet Cell; Blood Glucose; Glucagon; Humans; Insulinoma; Pancreatic Neoplasms; Tolbutamide | 1961 |
Amylin in pancreatic islets and pancreatic endocrine neoplasms.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amyloid; Biomarkers, Tumor; Female; Glucagon; Glucagonoma; Humans; Immunoenzyme Techniques; Insulin; Insulinoma; Islet Amyloid Polypeptide; Islets of Langerhans; Male; Middle Aged; Pancreatic Neoplasms; Pancreatic Polypeptide; Somatostatin | 2003 |
Expression in murine teratocarcinoma F9 cells of transcription factors involved in pancreas development.
Topics: Animals; Cell Line; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Glucagon; Glucose; Homeobox Protein Nkx-2.2; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Mice; Pancreatic Neoplasms; Pancreatic Polypeptide; Reverse Transcriptase Polymerase Chain Reaction; Somatostatin; Transcription, Genetic | 2004 |
Engineered beta-cells secreting dipeptidyl peptidase IV-resistant glucagon-like peptide-1 show enhanced glucose-responsiveness.
Topics: Animals; Cell Line, Tumor; Clone Cells; Cricetinae; Cricetulus; Cyclic AMP; Dipeptidyl Peptidase 4; Genetic Engineering; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose; Humans; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Peptide Fragments; Protein Precursors; Rabbits; Rats; Receptors, Glucagon; Transfection | 2005 |
Hypoglycemia in response to glucose and glucagon in insulinoma patients with a negative prolonged fast: functional and morphological properties.
Topics: Aged; Aged, 80 and over; Calcium; Fasting; Female; Glucagon; Glucose; Glucose Tolerance Test; Hepatic Veins; Humans; Hypoglycemia; Hypoglycemic Agents; Injections, Intra-Arterial; Injections, Intravenous; Insulin; Insulin Secretion; Insulinoma; Male; Pancreatic Neoplasms; Time Factors | 2004 |
Glucagon production of the rat insulinoma cell line INS-1-A quantitative comparison with primary rat pancreatic islets.
Topics: Animals; Cell Line, Tumor; Glucagon; Insulinoma; Islets of Langerhans; Palmitic Acid; Radioimmunoassay; Rats; RNA, Messenger | 2005 |
Glucagon-like peptide-1 stimulates human insulin promoter activity in part through cAMP-responsive elements that lie upstream and downstream of the transcription start site.
Topics: Animals; Cell Line, Tumor; Cyclic AMP; Electrophoretic Mobility Shift Assay; Gene Expression; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Insulinoma; Peptide Fragments; Promoter Regions, Genetic; Protein Precursors; Rats; Response Elements; Transcription Initiation Site; Transfection | 2005 |
Noninsulinoma pancreatogenous hypoglycemia syndrome: a rare case of adult-onset nesidioblastosis.
Topics: Age of Onset; Aged; Calcium Gluconate; Glucagon; Humans; Hypoglycemia; Insulin; Insulinoma; Male; Nesidioblastosis; Pancreatic Neoplasms; Somatostatin; Syndrome | 2005 |
Metastatic insulinoma and glucagonoma from the pancreas responsible for specific peritumoral patterns of hepatic steatosis secondary to local effects of insulin and glucagon on hepatocytes.
Topics: Adult; Fatty Liver; Female; Glucagon; Glucagonoma; Hepatocytes; Humans; Insulin; Insulin Secretion; Insulinoma; Liver; Liver Neoplasms; Pancreatic Neoplasms; Radiography | 2005 |
Establishment of glucagon-producing cells by cell hybridization.
Topics: Adenoma, Islet Cell; Animals; Cell Fusion; Cell Line; Cricetinae; Glucagon; Glucose; Histocytochemistry; Hybrid Cells; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Mesocricetus; Microscopy, Phase-Contrast; Neoplasm Transplantation; Theophylline | 1984 |
[Tumors of the endocrine pancreas].
Topics: Adenoma, Islet Cell; Adolescent; Adult; Aged; Child; Female; Follow-Up Studies; Gastrectomy; Gastrins; Glucagon; Humans; Hyperplasia; Insulin; Insulinoma; Islets of Langerhans; Male; Middle Aged; Pancreatectomy; Pancreatic Neoplasms; Postoperative Complications; Stomach Neoplasms; Zollinger-Ellison Syndrome | 1984 |
Insulin secretion by a transplantable rat islet cell tumour.
Topics: Adenoma, Islet Cell; Animals; Colchicine; Epinephrine; Glucagon; Glucose; Insulin; Insulin Secretion; Insulinoma; Kinetics; Neoplasms, Experimental; Pancreatic Neoplasms; Rats; Rats, Inbred Strains; Somatostatin; Theophylline; Trifluoperazine; Vinblastine | 1981 |
[The APUD concept and its clinical significance. 1].
Topics: APUD Cells; Apudoma; Gastric Inhibitory Polypeptide; Gastrins; Glucagon; Glucagon-Like Peptides; Humans; Insulin; Insulinoma; Motilin; Pancreatic Neoplasms; Secretin | 1982 |
Immunochemical identification of endocrine cell types in the streptozotocin nicotinamide-induced rat islet adenoma.
Topics: Adenoma, Islet Cell; Animals; Glucagon; Histocytochemistry; Immunochemistry; Insulin; Insulinoma; Niacinamide; Pancreatic Neoplasms; Radioimmunoassay; Rats; Rats, Inbred Strains; Somatostatin; Streptozocin | 1982 |
Fuel-induced insulin release in vitro from insulinomas transplanted into the rat kidney.
Topics: Adenoma, Islet Cell; Animals; Cytochalasin B; Diazoxide; Glucagon; Glucose; Glyceraldehyde; Humans; In Vitro Techniques; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Keto Acids; Kidney; Male; Neoplasm Transplantation; Pancreatic Neoplasms; Radioimmunoassay; Rats; Somatostatin | 1984 |
Immunohistochemical study of an insulinoma.
Topics: Adenoma, Islet Cell; Glucagon; Humans; Insulin; Insulinoma; Microscopy, Electron; Pancreatic Neoplasms; Somatostatin; Vasoactive Intestinal Peptide | 1983 |
Pharmacological modifications of insulin release in vitro from fuel-responsive transplantable insulinomas.
Topics: Acetylcholine; Adenoma, Islet Cell; Animals; Blood Glucose; Glucagon; Glucose; Insulin; Insulinoma; Isoproterenol; Kidney; Neoplasm Transplantation; Organ Size; Pancreatic Neoplasms; Perfusion; Rats; Rats, Inbred Strains; Somatostatin; Tolbutamide | 1984 |
L-leucine methyl ester stimulates insulin secretion and islet glutamate dehydrogenase.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line; Glucagon; Glucose; Glutamate Dehydrogenase; Glutamine; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Kinetics; Leucine; Male; Mice; Mice, Inbred Strains; Norepinephrine; Pancreatic Neoplasms; Rats | 1983 |
Lack of suppression of insulin secretion by exercise in patients with insulinoma.
Topics: Adenoma, Islet Cell; Adult; Aged; Blood Glucose; Female; Glucagon; Humans; Insulin; Insulin Secretion; Insulinoma; Pancreatic Neoplasms; Physical Exertion | 1981 |
[The insulinoma case diagnosed by the use of glucagon test (author's transl)].
Topics: Adenoma, Islet Cell; Adult; Blood Glucose; Female; Glucagon; Humans; Insulin; Insulinoma; Pancreatic Neoplasms | 1981 |
Plasma insulin response to various secretagogues in insulinoma.
Topics: Adenoma, Islet Cell; Adult; Aged; Arginine; Blood Glucose; Child; Fasting; Female; Glucagon; Glucose Tolerance Test; Humans; Insulin; Insulinoma; Male; Middle Aged; Pancreatic Neoplasms; Radioimmunoassay; Tolbutamide | 1982 |
Validation of a rapid solid-phase radioimmunoassay for canine, bovine, and equine insulin.
Topics: Adenoma, Islet Cell; Animals; Carcinoma; Cattle; Chromatography, Gel; Dog Diseases; Dogs; Female; Glucagon; Glucose; Horse Diseases; Horses; Hypoglycemia; Insulin; Insulinoma; Male; Pancreatic Neoplasms; Radioimmunoassay | 1982 |
Insulin and C-peptide in plasma and tumor of insulinoma patients.
Topics: Adenoma, Islet Cell; Adult; Aged; Blood Glucose; C-Peptide; Chromatography, Gel; Fasting; Female; Glucagon; Glucose Tolerance Test; Humans; Insulin; Insulinoma; Male; Middle Aged; Pancreatic Neoplasms; Peptides | 1983 |
Evidence for a therapeutic effect of dl-propranolol in benign and malignant insulinoma: report of three cases.
Topics: Adenoma, Islet Cell; Aged; Blood Glucose; Female; Glucagon; Glucose Tolerance Test; Humans; Insulin; Insulinoma; Middle Aged; Pancreatic Neoplasms; Propranolol | 1983 |
Diazoxide infusion test in patients with single benign insulinoma.
Topics: Adenoma, Islet Cell; Adult; Aged; Blood Glucose; Diazoxide; Glucagon; Humans; Insulin; Insulinoma; Kinetics; Middle Aged; Pancreatic Neoplasms | 1983 |
[Therapy of hypoglycemia in the adult].
Topics: Adenoma, Islet Cell; Adult; Diazoxide; Glucagon; Glucose; Humans; Hypoglycemia; Injections, Intravenous; Insulinoma; Patient Education as Topic; Phenytoin | 1983 |
Functional and morphologic characterization of human insulinomas.
Topics: Adenoma, Islet Cell; Adolescent; Adult; Aged; Female; Fluorescent Antibody Technique; Glucagon; Growth Hormone; Humans; Insulin; Insulin Secretion; Insulinoma; Male; Microscopy, Electron; Middle Aged; Pancreatic Function Tests; Pancreatic Neoplasms; Pancreatic Polypeptide; Proinsulin; Radioimmunoassay | 1983 |
Thiol-protein disulfide oxidoreductase and peptidase activities in insulinoma tissue.
Topics: Adenoma, Islet Cell; Adult; Biotransformation; Chromatography, Gel; Glucagon; Humans; Hydrogen-Ion Concentration; Insulin; Insulinoma; Kinetics; Male; Oxidoreductases; Pancreatic Neoplasms; Peptide Hydrolases; Protein Disulfide Reductase (Glutathione); Radioimmunoassay | 1983 |
Secretory granules in benign and malignant glucagonomas of the pancreas.
Topics: Adenoma, Islet Cell; Adult; C-Peptide; Cytoplasmic Granules; Glucagon; Glucagonoma; Humans; Insulinoma; Male; Neoplasm Metastasis; Neoplasms, Multiple Primary; Pancreatic Neoplasms; Radioimmunoassay | 1984 |
Analysis of insulin secretion based on changes in plasma insulin and C-peptide in man.
Topics: Adult; Aged; Arginine; C-Peptide; Diabetes Mellitus; Female; Glucagon; Glucose Tolerance Test; Humans; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Liver Cirrhosis; Male; Middle Aged; Nephritis; Pancreatic Neoplasms; Peptides; Tolbutamide | 1982 |
Signal transduction of the GLP-1-receptor cloned from a human insulinoma.
Topics: Amino Acid Sequence; Animals; Blotting, Northern; Calcium; Cell Line; Cloning, Molecular; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Insulinoma; Molecular Sequence Data; Peptide Fragments; Rats; Receptors, Glucagon; Recombinant Proteins; RNA; Sequence Homology, Amino Acid; Signal Transduction; Transfection | 1994 |
Activation of a cAMP-regulated Ca(2+)-signaling pathway in pancreatic beta-cells by the insulinotropic hormone glucagon-like peptide-1.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Calcium; Cell Line; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Insulinoma; Ion Channels; Islets of Langerhans; Membrane Potentials; Peptide Fragments; Protein Precursors; Rats; Signal Transduction; Tumor Cells, Cultured | 1995 |
Glucagon-like peptide-1 affects gene transcription and messenger ribonucleic acid stability of components of the insulin secretory system in RIN 1046-38 cells.
Topics: Animals; Culture Media, Conditioned; Cycloheximide; Dactinomycin; Drug Stability; Drug Synergism; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Glucose; Glucose Transporter Type 1; Hexokinase; Insulin; Insulin Secretion; Insulinoma; Monosaccharide Transport Proteins; Pancreatic Neoplasms; Peptide Fragments; Protein Precursors; Rats; RNA, Messenger; Transcription, Genetic; Tumor Cells, Cultured | 1995 |
Molecular cloning, functional expression, and signal transduction of the GIP-receptor cloned from a human insulinoma.
Topics: Amino Acid Sequence; Animals; Base Sequence; Binding, Competitive; Clone Cells; Cricetinae; Gastric Inhibitory Polypeptide; Gene Library; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Insulinoma; Kinetics; Molecular Sequence Data; Pancreatic Neoplasms; Peptide Fragments; Protein Precursors; Rats; Receptors, Gastrointestinal Hormone; Receptors, Glucagon; Recombinant Proteins; Sequence Homology, Amino Acid; Signal Transduction; Substrate Specificity; Swine; Transfection; Tumor Cells, Cultured | 1995 |
Surgical removal of insulinoma restores glucose recovery from hypoglycaemia but does not normalize insulin action.
Topics: Adult; Blood Glucose; Female; Glucagon; Growth Hormone; Homeostasis; Humans; Hypoglycemia; Insulin; Insulinoma; Male; Middle Aged; Pancreatic Neoplasms | 1995 |
Amylin alters the biological action of the incretin hormone GLP-1(7-36)amide.
Topics: Adenylyl Cyclases; Amyloid; Animals; Cell Line; Colforsin; Cyclic AMP; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose Intolerance; Insulinoma; Islet Amyloid Polypeptide; Islets of Langerhans; Models, Biological; Peptide Fragments; Peptides; Rats; Substance P | 1993 |
Glucagon-like peptide I increases cytoplasmic calcium in insulin-secreting beta TC3-cells by enhancement of intracellular calcium mobilization.
Topics: Animals; Calcium; Calcium Channels; Cell Line; Colforsin; Cyclic AMP; Cytoplasm; Dose-Response Relationship, Drug; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Inositol Phosphates; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Kinetics; Mice; Mice, Transgenic; Pancreatic Neoplasms; Peptide Fragments; Ryanodine; Time Factors; Tumor Cells, Cultured | 1995 |
The glucagon gene is transcribed in beta-like pancreatic cells.
Topics: Animals; Base Sequence; Binding Sites; Cell Line, Transformed; Glucagon; Glucagonoma; Humans; Insulinoma; Islets of Langerhans; Molecular Sequence Data; Polymerase Chain Reaction; Rats; Sequence Alignment; Transcription, Genetic | 1995 |
Expression of insulin receptor on clonal pancreatic alpha cells and its possible role for insulin-stimulated negative regulation of glucagon secretion.
Topics: Animals; Base Sequence; Blotting, Northern; Clone Cells; Cricetinae; DNA Primers; Gene Expression; Glucagon; Humans; Immunohistochemistry; Insulin; Insulinoma; Kinetics; Methionine; Molecular Sequence Data; Pancreatic Neoplasms; Polymerase Chain Reaction; Receptor, Insulin; RNA, Messenger; Sulfur Radioisotopes; Tumor Cells, Cultured | 1995 |
A novel insulin secretagogue is a phosphodiesterase inhibitor.
Topics: Animals; Calcium; Cells, Cultured; Cyclic AMP; Dose-Response Relationship, Drug; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Mice; Mice, Inbred C57BL; Mice, Obese; Pancreatic Neoplasms; Peptide Fragments; Phosphodiesterase Inhibitors; Piperazines; Protein Precursors; Tumor Cells, Cultured | 1995 |
Glucagon-like peptide-1 (GLP-1) molecular forms in human pancreatic endocrine tumors resemble those in intestine rather than pancreas.
Topics: Chromatography, High Pressure Liquid; Glucagon; Glucagon-Like Peptide 1; Glucagonoma; Humans; Insulinoma; Pancreatic Neoplasms; Peptide Fragments; Protein Precursors; Radioimmunoassay; Reference Values | 1994 |
The role of prohormone convertases PC1 (PC3) and PC2 in the cell-specific processing of proglucagon.
Topics: Animals; Aspartic Acid Endopeptidases; Base Sequence; Blotting, Northern; Cell Line; Chromatography, High Pressure Liquid; DNA Primers; Glucagon; Glucagon-Like Peptides; Insulinoma; Molecular Sequence Data; Oxyntomodulin; Pancreatic Neoplasms; Peptide Fragments; Pituitary Neoplasms; Polymerase Chain Reaction; Proglucagon; Proprotein Convertase 2; Proprotein Convertases; Protein Precursors; Protein Processing, Post-Translational; Rats; RNA, Messenger; Subtilisins; Transfection | 1995 |
Structure/activity characterization of glucagon-like peptide-1.
Topics: Amino Acid Sequence; Animals; Binding Sites; Binding, Competitive; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Insulinoma; Kinetics; Molecular Sequence Data; Pancreatic Neoplasms; Peptide Fragments; Protein Precursors; Rats; Receptors, Cell Surface; Receptors, Glucagon; Structure-Activity Relationship; Tumor Cells, Cultured | 1994 |
Ras antagonizes cAMP stimulated glucagon gene transcription in pancreatic islet cell lines.
Topics: Adenoma, Islet Cell; Animals; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Genes, Dominant; Genes, ras; Glucagon; Glucagonoma; Insulinoma; Mutation; Promoter Regions, Genetic; Protein Kinase C; ras Proteins; Rats; Recombinant Fusion Proteins; RNA, Messenger; Signal Transduction; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 1994 |
Incretin hormones regulate glucose-dependent insulin secretion in RIN 1046-38 cells: mechanisms of action.
Topics: Animals; Calcium; Dose-Response Relationship, Drug; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Insulin Secretion; Insulinoma; Kinetics; Membrane Potentials; Pancreatic Neoplasms; Peptide Fragments; Potassium Chloride; Protein Precursors; Rats; Signal Transduction; Tumor Cells, Cultured | 1994 |
[Benign insulinoma. Efficacy of preoperative treatment for persistent hyperinsulinemia using a synthetic somatostatin analog].
Topics: Aged; Blood Glucose; C-Peptide; Combined Modality Therapy; Female; Glucagon; Humans; Insulin; Insulinoma; Octreotide; Pancreatic Neoplasms | 1994 |
Chromostatin, a chromogranin A-derived bioactive peptide, is present in human pancreatic insulin (beta) cells.
Topics: Adrenal Medulla; Chromogranin A; Chromogranins; Diabetes Mellitus, Type 1; Glucagon; Humans; Immune Sera; Immunohistochemistry; Insulin; Insulinoma; Islets of Langerhans; Microscopy, Immunoelectron; Pancreas; Pancreatic Neoplasms; Pancreatic Polypeptide; Peptide Fragments; Somatostatin | 1993 |
Multiple endocrine neoplasm, type 1. Gastrinomas, pancreatic neoplasms, microcarcinoids, the Zollinger-Ellison syndrome, lymph nodes, and hepatic metastases.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Female; Follow-Up Studies; Gastrinoma; Gastrins; Glucagon; Humans; Insulin; Insulinoma; Liver Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Multiple Endocrine Neoplasia; Pancreatic Neoplasms; Prospective Studies; Retrospective Studies; Zollinger-Ellison Syndrome | 1993 |
Detection of the human glucagon-like peptide 1(7-36) amide receptor on insulinoma-derived cell membranes.
Topics: Animals; Cell Membrane; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Humans; Insulinoma; Islets of Langerhans; Pancreatic Neoplasms; Peptide Fragments; Rats; Receptors, Cell Surface; Receptors, Glucagon; Tumor Cells, Cultured | 1994 |
Structure-activity relationships of glucagon-like peptide-1(7-36)amide: insulinotropic activities in perfused rat pancreases, and receptor binding and cyclic AMP production in RINm5F cells.
Topics: Animals; Cell Line; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Insulin; Insulinoma; Male; Pancreas; Peptide Fragments; Perfusion; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, Glucagon; Stimulation, Chemical; Structure-Activity Relationship | 1994 |
Sulfonylurea-binding sites and ATP-sensitive K+ channels in alpha-TC glucagonoma and beta-TC insulinoma cells.
Topics: Adenosine Triphosphate; Animals; Binding Sites; Binding, Competitive; Diazoxide; Glucagon; Glucagonoma; Glyburide; Insulinoma; Kinetics; Membrane Potentials; Mice; Pancreatic Neoplasms; Potassium Channels; Tolbutamide; Tritium; Tumor Cells, Cultured | 1993 |
Insulin surrogates in insulinoma.
Topics: 3-Hydroxybutyric Acid; Adolescent; Adult; Aged; Blood Glucose; C-Peptide; Fasting; Fatty Acids, Nonesterified; Female; Glucagon; Humans; Hydroxybutyrates; Insulin; Insulinoma; Male; Middle Aged; Pancreatic Neoplasms | 1993 |
Amino-terminal parathyroid hormone-related protein: specific binding and cytosolic calcium responses in rat insulinoma cells.
Topics: Animals; Binding Sites; Calcium; Cell Membrane; Cyclic AMP; Cytosol; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glyburide; Insulinoma; Kinetics; Pancreatic Neoplasms; Parathyroid Hormone; Parathyroid Hormone-Related Protein; Peptide Fragments; Peptides; Proteins; Rats; Rats, Inbred WF; Tumor Cells, Cultured | 1993 |
Neuropeptide Y expression and regulation in a differentiated rat insulin-secreting cell line.
Topics: Adenylyl Cyclases; Animals; Cell Differentiation; Clonidine; Colforsin; Cyclic AMP; Enzyme Activation; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation, Neoplastic; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Insulin; Insulin Secretion; Insulinoma; Neuropeptide Y; Pancreatic Neoplasms; Peptide Fragments; Protein Kinase C; Rats; Receptors, Neuropeptide Y; Tumor Cells, Cultured | 1993 |
Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulin-secreting beta-cells.
Topics: Animals; Binding, Competitive; Cell Line; Cell Membrane; Cyclic AMP; Exenatide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Insulin; Insulin Secretion; Insulinoma; Kinetics; Lizards; Lung; Pancreatic Neoplasms; Peptide Fragments; Peptides; Rats; Receptors, Cell Surface; Receptors, Glucagon; Tumor Cells, Cultured; Venoms | 1993 |
Abnormal facilitative glucose transporter gene expression in human islet cell tumors.
Topics: Base Sequence; Female; Gastrinoma; Gastrins; Gene Expression; Gene Expression Regulation, Neoplastic; Glucagon; Glucagonoma; Humans; Insulin; Insulinoma; Male; Middle Aged; Molecular Sequence Data; Monosaccharide Transport Proteins; Oligodeoxyribonucleotides; Pancreatic Neoplasms; Polymerase Chain Reaction; RNA, Messenger | 1993 |
The Gly40Ser mutation in the human glucagon receptor gene associated with NIDDM results in a receptor with reduced sensitivity to glucagon.
Topics: Amino Acid Sequence; Animals; Cell Line; Cricetinae; Cyclic AMP; Diabetes Mellitus, Type 2; Exons; Glucagon; Glycine; Humans; Insulin; Insulin Secretion; Insulinoma; Kidney; Kinetics; Molecular Sequence Data; Pancreatic Neoplasms; Point Mutation; Protein Structure, Secondary; Rats; Receptors, Glucagon; Recombinant Proteins; Serine; Transfection | 1996 |
Desensitization of glucagon-like peptide 1 receptors in insulin-secreting beta TC3 cells: role of PKA-independent mechanisms.
Topics: Animals; Calcium; Glucagon; Glucose; Insulinoma; Mice; Mice, Inbred Strains; Protein Kinase C; Receptors, Glucagon; Time Factors; Tumor Cells, Cultured | 1996 |
GLP-1/GIP chimeric peptides define the structural requirements for specific ligand-receptor interaction of GLP-1.
Topics: Amino Acid Sequence; Animals; Chloramines; Cyclic AMP; Dose-Response Relationship, Drug; Gastric Inhibitory Polypeptide; Gastrointestinal Agents; Glucagon; Glucagon-Like Peptide 1; Indicators and Reagents; Insulinoma; Iodine Radioisotopes; Molecular Sequence Data; Peptide Fragments; Protein Precursors; Radioligand Assay; Rats; Recombinant Fusion Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Structure-Activity Relationship; Tosyl Compounds; Tumor Cells, Cultured | 1996 |
Glucagon acts through its own receptors in the presence of functional glucagon-like peptide-1 receptors on hamster insulinoma.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Cell Line; Cell Membrane; Cricetinae; Cross-Linking Reagents; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Insulinoma; Islets of Langerhans; Mice; Pancreatic Neoplasms; Peptide Fragments; Peptides; Receptors, Glucagon; RNA, Messenger | 1996 |
Signal transduction and desensitization of the glucagon-like peptide-1 receptor.
Topics: Animals; Cyclic AMP; Gene Deletion; Glucagon; Glucagon-Like Peptide 1; Humans; Insulinoma; Mutation; Peptide Fragments; Phosphorylation; Protein Precursors; Receptors, Glucagon; Sensitivity and Specificity; Signal Transduction; Tumor Cells, Cultured | 1996 |
The signal transduction of the glucagon-like peptide 1 receptor: fishing beyond the protein kinase level.
Topics: Colforsin; Electrophoresis, Gel, Two-Dimensional; Glucagon; Glucagon-Like Peptide 1; Insulinoma; Isoelectric Focusing; Molecular Weight; Peptide Fragments; Phosphoproteins; Phosphorylation; Protein Kinases; Protein Precursors; Receptors, Glucagon; Signal Transduction; Tumor Cells, Cultured | 1996 |
Glucagon-like peptide-1(7-36)amide and cytoplasmic calcium in insulin producing cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Cytoplasm; Fura-2; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Insulin; Insulinoma; Islets of Langerhans; Male; Neurotransmitter Agents; Peptide Fragments; Phosphodiesterase Inhibitors; Protein Precursors; Rats; Rats, Sprague-Dawley; Sincalide; Tumor Cells, Cultured | 1996 |
Desensitization and phosphorylation of the glucagon-like peptide-1 (GLP-1) receptor by GLP-1 and 4-phorbol 12-myristate 13-acetate.
Topics: Amino Acid Sequence; Animals; Blotting, Western; Cyclic AMP; Enzyme Activation; Enzyme Inhibitors; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Indoles; Insulinoma; Molecular Sequence Data; Pancreatic Neoplasms; Peptide Fragments; Phosphorylation; Protein Kinase C; Protein Precursors; Rats; Receptors, Glucagon; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1996 |
Effects of glucagon-like peptide-1 (GLP-1) in RINm5F insulinoma cells. Stimulation of insulin secretion, insulin content, and insulin receptor binding.
Topics: Animals; Glucagon; Glucagon-Like Peptide 1; Insulin; Insulinoma; Iodine Radioisotopes; Microscopy, Electron; Pancreatic Neoplasms; Peptide Fragments; Protein Precursors; Rats; Receptor, Insulin; Tumor Cells, Cultured | 1995 |
Ligand-induced regulation of glucagon-like peptide-I receptor function and expression in insulin-secreting beta cells.
Topics: Animals; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Enzyme Activation; Gene Expression; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Guanosine 5'-O-(3-Thiotriphosphate); Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Pancreatic Neoplasms; Peptide Fragments; Protein Precursors; Protein Synthesis Inhibitors; Rats; Receptors, Glucagon; RNA, Messenger; Tumor Cells, Cultured | 1996 |
Clinical spectrum of hyperglucagonemia associated with malignant neuroendocrine tumors.
Topics: Adult; Aged; Blood Glucose; Carcinoid Tumor; Diabetes Mellitus; Female; Glucagon; Glucagonoma; Hormones; Humans; Insulinoma; Male; Middle Aged; Multiple Endocrine Neoplasia; Neuroendocrine Tumors; Retrospective Studies; Zollinger-Ellison Syndrome | 1996 |
FA1 immunoreactivity in endocrine tumours and during development of the human fetal pancreas; negative correlation with glucagon expression.
Topics: Antibodies, Monoclonal; Endocrine Gland Neoplasms; Epidermal Growth Factor; Fetus; Fluorescent Antibody Technique; Glucagon; Glucagonoma; Glycoproteins; Humans; Insulin; Insulinoma; Neuroendocrine Tumors; Pancreas; Pheochromocytoma; Somatostatin; Tumor Cells, Cultured | 1996 |
[Endocrine function of the pancreas in patients with organic hyperinsulinism syndrome].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Blood Glucose; C-Peptide; Female; Glucagon; Humans; Hyperinsulinism; Insulin; Insulinoma; Islets of Langerhans; Male; Middle Aged; Pancreatic Neoplasms; Radioimmunoassay | 1996 |
Regulation of glycosylphosphatidylinositol-specific phospholipase D secretion from beta TC3 cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Carbachol; Cycloheximide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Immunohistochemistry; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Kinetics; Mice; Pancreatic Neoplasms; Peptide Fragments; Phospholipase D; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1997 |
Tissue-specific and glucose-dependent expression of receptor genes for glucagon and glucagon-like peptide-1 (GLP-1).
Topics: Animals; DNA, Complementary; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulinoma; Islets of Langerhans; Mice; Mice, Inbred C57BL; Peptides; Protein Biosynthesis; Protein Precursors; RNA, Messenger; Tissue Distribution; Tumor Cells, Cultured | 1997 |
Chromogranin A plasma concentration and expression in pancreatic islet cell tumors of dogs and cats.
Topics: Animals; Cat Diseases; Cats; Cattle; Chromogranin A; Chromogranins; Dog Diseases; Dogs; Gene Expression Regulation, Neoplastic; Glucagon; Immune Sera; Immunohistochemistry; Insulin; Insulinoma; Pancreas; Pancreatic Neoplasms; Pancreatic Polypeptide; Phosphopyruvate Hydratase; Radioimmunoassay; Somatostatin | 1997 |
Endoproteolysis of glucagon-like peptide (GLP)-1 (7-36) amide by ectopeptidases in RINm5F cells.
Topics: Amino Acid Sequence; Animals; Cell Membrane; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Hydrolysis; Insulinoma; Peptide Fragments; Peptide Hydrolases; Rats; Tumor Cells, Cultured | 1997 |
Cloning and characterization of the 5' flanking sequences (promoter region) of the human GLP-1 receptor gene.
Topics: Base Sequence; Cloning, Molecular; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Humans; Insulinoma; Molecular Sequence Data; Peptide Fragments; Promoter Regions, Genetic; Receptors, Glucagon; Sequence Analysis, DNA; Transcription, Genetic; Tumor Cells, Cultured | 1997 |
Insulinoma associated with a case of multiple endocrine neoplasia type I: Functional somatostatin receptors and abnormal glucose-induced insulin secretion.
Topics: Actins; Adolescent; Dose-Response Relationship, Drug; Follow-Up Studies; Gene Expression Regulation, Neoplastic; Glucagon; Glucose; Glucose Transporter Type 1; Hormones; Humans; Hyperparathyroidism; Immunohistochemistry; Injections, Intravenous; Insulin; Insulin Secretion; Insulinoma; Male; Monosaccharide Transport Proteins; Multiple Endocrine Neoplasia Type 1; Octreotide; Pancreatic Neoplasms; Parathyroid Neoplasms; Receptors, Somatostatin; RNA, Messenger; Tomography, Emission-Computed, Single-Photon | 1997 |
Return of beta-adrenergic sensitivity in a patient with insulinoma after removal of the tumour.
Topics: Adrenergic beta-Agonists; Adult; Blood Glucose; Epinephrine; Glucagon; Human Growth Hormone; Humans; Hydrocortisone; Hypoglycemia; Insulinoma; Isoproterenol; Male; Pancreatic Neoplasms; Receptors, Adrenergic, beta | 1997 |
[Features of anesthesia in surgical removal of insulinoma].
Topics: Anesthesia, General; Glucagon; Hemodynamics; Humans; Insulin; Insulinoma; Neuroleptanalgesia; Neuromuscular Nondepolarizing Agents; Pancreatic Neoplasms; Pipecuronium | 1997 |
Effect of chronic central administration of glucagon-like peptide-1 (7-36) amide on food consumption and body weight in normal and obese rats.
Topics: Animals; Body Weight; Eating; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Injections, Intraventricular; Insulinoma; Male; Neurotransmitter Agents; Obesity; Pancreatic Neoplasms; Peptide Fragments; Rats; Rats, Sprague-Dawley; Rats, Zucker; Receptors, Glucagon; Tumor Cells, Cultured | 1998 |
The role of glucagon administration in the diagnosis and treatment of patients with tumor hypoglycemia.
Topics: Adult; Aged; Blood Glucose; Carcinoma; Carcinoma, Hepatocellular; Colonic Neoplasms; Female; Glucagon; Hemangiopericytoma; Humans; Hypoglycemia; Infusion Pumps; Insulinoma; Liver Neoplasms; Meningeal Neoplasms; Middle Aged; Pancreatic Neoplasms; Sarcoma | 1998 |
Central infusion of glucagon-like peptide-1-(7-36) amide (GLP-1) receptor antagonist attenuates lithium chloride-induced c-Fos induction in rat brainstem.
Topics: Animals; Brain Stem; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Guinea Pigs; Infusions, Parenteral; Injections, Intraperitoneal; Injections, Intraventricular; Insulin; Insulin Secretion; Insulinoma; Lithium Chloride; Male; Neurons; Peptide Fragments; Proto-Oncogene Proteins c-fos; Rats; Rats, Long-Evans; Receptors, Glucagon; Signal Transduction; Tumor Cells, Cultured | 1998 |
Contribution of a PS1-like element to the tissue- and cell-specific expression of the human GLP-1 receptor gene.
Topics: Animals; Base Sequence; Cell Line; Cell Nucleus; Cloning, Molecular; Cricetinae; Enhancer Elements, Genetic; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagonoma; Humans; Insulinoma; Islets of Langerhans; Molecular Sequence Data; Mutagenesis, Site-Directed; Organ Specificity; Pancreatic Neoplasms; Peptide Fragments; Promoter Regions, Genetic; Protein Precursors; Receptors, Glucagon; Recombinant Proteins; Sequence Deletion; Sequence Homology, Nucleic Acid; Simian virus 40; Transfection; Tumor Cells, Cultured | 1998 |
Inhibition of glucose stimulated insulin secretion by neuropeptide Y is mediated via the Y1 receptor and inhibition of adenylyl cyclase in RIN 5AH rat insulinoma cells.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Blotting, Northern; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Insulin Secretion; Insulinoma; Iodine Radioisotopes; Isoproterenol; Neuropeptide Y; Pancreatic Neoplasms; Peptide Fragments; Peptide YY; Protein Precursors; Rats; Receptors, Neuropeptide Y; Swine; Tumor Cells, Cultured | 1998 |
Evaluation of immunoisolated insulin-secreting beta TC6-F7 cells as a bioartificial pancreas.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blood Glucose; Capsules; Cell Division; Cell Separation; Diabetes Mellitus, Experimental; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Insulin; Insulin Secretion; Insulinoma; Pancreas, Artificial; Pancreatic Neoplasms; Peptide Fragments; Protein Precursors; Rats; Rats, Wistar; Time Factors; Tumor Cells, Cultured | 1997 |
Glucagon-like peptide-1 regulates the beta cell transcription factor, PDX-1, in insulinoma cells.
Topics: Animals; Glucagon; Glucagon-Like Peptide 1; Homeodomain Proteins; Insulinoma; Pancreatic Neoplasms; Peptide Fragments; Protein Precursors; Rats; RNA, Messenger; Trans-Activators; Tumor Cells, Cultured | 1999 |
GLP-1-analogues resistant to degradation by dipeptidyl-peptidase IV in vitro.
Topics: Animals; Binding, Competitive; Chromatography, High Pressure Liquid; Cyclic AMP; Dipeptidyl Peptidase 4; Glucagon; Glucagon-Like Peptide 1; Insulinoma; Molecular Structure; Peptide Fragments; Protein Precursors; Rats; Receptors, G-Protein-Coupled; Receptors, Gastrointestinal Hormone; Tumor Cells, Cultured | 2000 |
Abundant expression of 150-kDa oxygen-regulated protein in mouse pancreatic beta cells is correlated with insulin secretion.
Topics: Animals; Eating; Fasting; Glucagon; Glucose; HSP70 Heat-Shock Proteins; Immunohistochemistry; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Male; Membrane Proteins; Mice; Molecular Chaperones; Organ Specificity; Oxygen; Pancreatic Neoplasms; Proteins; Somatostatin; Tumor Cells, Cultured | 2000 |
Glucagon-like peptide-1 improves insulin and proinsulin binding on RINm5F cells and human monocytes.
Topics: Adult; Animals; Exenatide; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Humans; Insulin; Insulinoma; Male; Monocytes; Pancreatic Neoplasms; Peptide Fragments; Peptides; Proinsulin; Protein Precursors; Rats; Receptors, Glucagon; Tumor Cells, Cultured; Venoms | 2000 |
Regulation of the diabetes-associated autoantigen IA-2 in INS-1 pancreatic beta-cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Autoantigens; Colforsin; Cyclic AMP; Gene Expression Regulation; Glucagon; Glucose; Insulinoma; Islets of Langerhans; Kinetics; Membrane Proteins; Pancreatic Neoplasms; Protein Kinase C; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Rats; Receptor-Like Protein Tyrosine Phosphatases, Class 8; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Somatostatin; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2000 |
Glucagon-like peptide 1 stimulates insulin gene promoter activity by protein kinase A-independent activation of the rat insulin I gene cAMP response element.
Topics: Animals; Base Sequence; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Insulin; Insulinoma; Luciferases; Pancreatic Neoplasms; Peptide Fragments; Promoter Regions, Genetic; Protein Precursors; Rats; Recombinant Fusion Proteins; Second Messenger Systems; Sequence Deletion; Transcription, Genetic; Tumor Cells, Cultured; Venoms | 2000 |
Ca2+ and electrolyte mobilization following agonist application to the pancreatic beta cell line HIT.
Topics: Animals; Calcium; Cytoplasm; Cytoplasmic Granules; Electrolytes; Electron Probe Microanalysis; Extracellular Space; Glucagon; Glucagon-Like Peptide 1; Insulinoma; Islets of Langerhans; Microscopy, Confocal; Microscopy, Electron; Pancreatic Neoplasms; Peptide Fragments; Protein Precursors; Tumor Cells, Cultured | 2000 |
Pdx1 level defines pancreatic gene expression pattern and cell lineage differentiation.
Topics: Animals; Cell Differentiation; Cell Line; Cell Nucleus; Cytoplasm; Gene Expression Regulation; Glucagon; Homeodomain Proteins; Insulinoma; Islets of Langerhans; Molecular Weight; Pancreas; Pancreatic Neoplasms; Rats; Trans-Activators; Tumor Cells, Cultured | 2001 |
Over-expression of the glucagon-like peptide-1 receptor on INS-1 cells confers autocrine stimulation of insulin gene promoter activity: a strategy for production of pancreatic beta-cell lines for use in transplantation.
Topics: Animals; Autocrine Communication; Cell Line; Diabetes Mellitus; Enzyme Inhibitors; Exenatide; Gene Expression Regulation; Genetic Engineering; Glucagon; Glucagon-Like Peptide 1; Indoles; Insulin; Insulinoma; Islets of Langerhans; Islets of Langerhans Transplantation; Peptide Fragments; Peptides; Promoter Regions, Genetic; Protein Kinase C; Protein Precursors; Rats; Receptors, Peptide; Recombinant Proteins; Research Design; Second Messenger Systems; Tumor Cells, Cultured; Venoms | 2002 |
An immunohistochemical approach to monitor the prolactin-induced activation of the JAK2/STAT5 pathway in pancreatic islets of Langerhans.
Topics: Animals; Biological Transport; Blotting, Western; Cell Nucleus; Cytoplasm; DNA-Binding Proteins; Enzyme Activation; Glucagon; Immunohistochemistry; Insulin; Insulinoma; Islets of Langerhans; Janus Kinase 2; Microscopy, Confocal; Milk Proteins; Pancreatic Neoplasms; Phosphorylation; Phosphotyrosine; Prolactin; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Rats; Receptors, Prolactin; Somatostatin; STAT5 Transcription Factor; Trans-Activators; Tumor Cells, Cultured | 2002 |
Expression of a novel zinc-finger cDNA, IA-1, is associated with rat AR42J cells differentiation into insulin-positive cells.
Topics: Adult; Animals; Basic Helix-Loop-Helix Transcription Factors; Cell Differentiation; Culture Media, Conditioned; DNA-Binding Proteins; DNA, Complementary; Fetus; Gene Expression Regulation, Developmental; Glucagon; Glucagon-Like Peptide 1; Homeodomain Proteins; Humans; Insulin; Insulinoma; Islets of Langerhans; Mice; Peptide Fragments; Protein Precursors; Rats; Repressor Proteins; RNA, Messenger; Trans-Activators; Tumor Cells, Cultured; Zinc Fingers | 2002 |
Use of the incretin hormone glucagon-like peptide-1 (GLP-1) for the detection of insulinomas: initial experimental results.
Topics: Animals; Chromatography, High Pressure Liquid; Feasibility Studies; Glucagon; Glucagon-Like Peptide 1; Insulinoma; Iodine Radioisotopes; Neoplasm Transplantation; Pancreatic Neoplasms; Peptide Fragments; Peptides; Protein Precursors; Radionuclide Imaging; Rats; Reproducibility of Results; Sensitivity and Specificity; Tissue Distribution; Tumor Cells, Cultured | 2002 |
Insulinotropic hormone glucagon-like peptide-I(7-37) stimulation of proinsulin gene expression and proinsulin biosynthesis in insulinoma beta TC-1 cells.
Topics: Animals; Chloramphenicol O-Acetyltransferase; Cyclic AMP; Diabetes Mellitus, Type 2; Gene Expression; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Insulin; Insulin Secretion; Insulinoma; Mice; Pancreatic Neoplasms; Peptide Fragments; Peptides; Proinsulin; Promoter Regions, Genetic; RNA, Messenger; Tumor Cells, Cultured | 1992 |
Solubilization of active GLP-1 (7-36)amide receptors from RINm5F plasma membranes.
Topics: Animals; Cations; Detergents; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Insulinoma; Pancreatic Neoplasms; Peptide Fragments; Peptides; Protein Binding; Rats; Receptors, Cell Surface; Receptors, Glucagon; Solubility; Thionucleotides; Tumor Cells, Cultured | 1992 |
Characterization of binding sites for oxyntomodulin on a somatostatin-secreting cell line (RIN T3).
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclases; Animals; Binding Sites; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Glucagon; Glucagon-Like Peptides; Insulinoma; Iodine Radioisotopes; Oxyntomodulin; Rats; Somatostatin; Tumor Cells, Cultured | 1992 |
Galanin inhibits proinsulin gene expression stimulated by the insulinotropic hormone glucagon-like peptide-I(7-37) in mouse insulinoma beta TC-1 cells.
Topics: Adenylate Cyclase Toxin; Animals; Blotting, Northern; Cell Line; Chloramphenicol O-Acetyltransferase; Colforsin; Galanin; Gene Expression; Gene Expression Regulation, Neoplastic; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Insulinoma; Kinetics; Mice; Models, Biological; Pancreatic Neoplasms; Peptide Fragments; Peptides; Pertussis Toxin; Proinsulin; RNA, Neoplasm; Transfection; Virulence Factors, Bordetella | 1992 |
Glucagonlike peptide-1(7-36)amide suppresses glucagon secretion and decreases cyclic AMP concentration in cultured In-R1-G9 cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Clone Cells; Cricetinae; Cyclic AMP; Dose-Response Relationship, Drug; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Insulinoma; Kinetics; Pancreatic Neoplasms; Peptide Fragments; Peptides | 1992 |
Multiple hormone secretion and gene expression in clones isolated from rat insulinoma cell lines.
Topics: Animals; Clone Cells; Gene Expression; Genes, ras; Glucagon; In Situ Hybridization; Insulin; Insulin Secretion; Insulinoma; Pancreatic Neoplasms; Ploidies; Rats; Tumor Cells, Cultured | 1992 |
[Insulinoma and octreotide].
Topics: Glucagon; Humans; Hypoglycemia; Insulinoma; Octreotide; Pancreatic Neoplasms | 1992 |
Monoclonal antibody-mediated cytotoxicity against rat beta cells detected in vitro does not cause beta-cell destruction in vivo.
Topics: Animals; Antibodies, Monoclonal; Antibody-Dependent Cell Cytotoxicity; Cell Line; Glucagon; Hybridomas; Insulin; Insulinoma; Islets of Langerhans; Mice; Mice, Inbred BALB C; Pancreatic Neoplasms; Rats | 1992 |
Homologous desensitization of the insulinotropic glucagon-like peptide-I (7-37) receptor on insulinoma (HIT-T15) cells.
Topics: Cyclic AMP; Down-Regulation; Gastric Inhibitory Polypeptide; Glucagon; Glucose; Insulin; Insulinoma; Pancreatic Neoplasms; Perfusion; Receptors, Gastrointestinal Hormone; Receptors, Glucagon; Tumor Cells, Cultured | 1991 |
Oxyntomodulin and related peptides control somatostatin secretion in RIN T3 cells.
Topics: Animals; Calcium; Carbachol; Cyclic AMP; Dose-Response Relationship, Drug; Glucagon; Glucagon-Like Peptides; In Vitro Techniques; Inositol Phosphates; Insulinoma; Oxyntomodulin; Peptide Fragments; Rats; Secretory Rate; Somatostatin; Time Factors; Tumor Cells, Cultured | 1991 |
The pancreatic islet-specific glucagon G3 transcription factors recognize control elements in the rat somatostatin and insulin-I genes.
Topics: Animals; Base Sequence; Binding Sites; Cell Nucleus; Cricetinae; Enhancer Elements, Genetic; Glucagon; Immunoblotting; Insulin; Insulinoma; Islets of Langerhans; Molecular Sequence Data; Oligodeoxyribonucleotides; Pancreatic Neoplasms; Rats; Sequence Homology, Nucleic Acid; Somatostatin; Transcription Factors | 1991 |
Differential glucocorticoid regulation of glucagon gene expression in cell lines derived from rat and hamster islet cell tumors.
Topics: Adenoma, Islet Cell; Animals; Blotting, Northern; Cell Line; Chloramphenicol O-Acetyltransferase; Cricetinae; Dexamethasone; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Glucagon; Glucocorticoids; In Vitro Techniques; Insulinoma; Male; Pancreatic Neoplasms; Radioimmunoassay; Rats; Rats, Inbred Strains; RNA; Transfection | 1991 |
Prolonged maximal stimulation of insulin secretion in healthy subjects does not provoke preferential release of proinsulin.
Topics: Adult; C-Peptide; Diabetes Mellitus, Type 2; Female; Glucagon; Humans; Hyperglycemia; Insulin; Insulin Secretion; Insulinoma; Male; Pancreatic Neoplasms; Proinsulin; Tolbutamide | 1991 |
Islet amyloid polypeptide and insulin expression are controlled differently in primary and transformed islet cells.
Topics: Amyloid; Animals; Animals, Newborn; Cell Line; Cell Line, Transformed; Gene Expression Regulation; Glucagon; Glucagonoma; Growth Hormone; Humans; Immunohistochemistry; Insulin; Insulinoma; Islet Amyloid Polypeptide; Islets of Langerhans; Mice; Pancreatic Neoplasms; Rats; RNA, Messenger; Simian virus 40; Transfection | 1991 |
Stimulatory effects of glucagon-like peptides on human insulinoma cells and insulin-releasing clonal RINm5F cells.
Topics: Adult; Animals; Cell Line; Cyclic AMP; Female; Glucagon; Glucose; Humans; Insulin; Insulin Secretion; Insulinoma; Kinetics; Pancreatic Neoplasms; Peptide Fragments; Rats; Structure-Activity Relationship | 1990 |
Human and rat amylin have no effects on insulin secretion in isolated rat pancreatic islets.
Topics: Amyloid; Animals; Cell Line; Cells, Cultured; Cricetinae; Glucagon; Glucose; Humans; In Vitro Techniques; Insulin; Insulin Secretion; Insulinoma; Islet Amyloid Polypeptide; Islets of Langerhans; Kinetics; Male; Pancreatic Neoplasms; Rats; Rats, Inbred Strains | 1991 |
Glucagon-like peptide-I analogs: effects on insulin secretion and adenosine 3',5'-monophosphate formation.
Topics: Animals; Cell Line; Cyclic AMP; Dose-Response Relationship, Drug; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Insulin; Insulin Secretion; Insulinoma; Male; Pancreas; Peptide Fragments; Peptides; Rats; Rats, Inbred Strains | 1990 |
A pancreatic islet cell-specific enhancer-like element in the glucagon gene contains two domains binding distinct cellular proteins.
Topics: Adenoma, Islet Cell; Animals; Base Sequence; Cell Line; Cell Nucleus; Deoxyribonucleases; DNA-Binding Proteins; DNA, Neoplasm; Enhancer Elements, Genetic; Glucagon; HeLa Cells; Humans; Insulinoma; Molecular Sequence Data; Mutation; Nucleotide Mapping; Oligonucleotide Probes; Pancreatic Neoplasms; Rats; Transcription, Genetic | 1990 |
Dexamethasone pretreatment of rat insulinoma cells decreases binding of glucagon-like peptide-1(7-36)amide.
Topics: Animals; Cyclic AMP; Dexamethasone; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucocorticoids; Insulinoma; Mifepristone; Pancreatic Neoplasms; Peptide Fragments; Peptides; Protein Binding; Rats; Time Factors; Tumor Cells, Cultured | 1990 |
P19, a hormonally regulated phosphoprotein of peptide hormone-producing cells: secretagogue-induced phosphorylation in AtT-20 mouse pituitary tumor cells and in rat and hamster insulinoma cells.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenoma, Islet Cell; Adrenocorticotropic Hormone; Animals; Colforsin; Corticotropin-Releasing Hormone; Cricetinae; Cyclic AMP; Electrophoresis, Polyacrylamide Gel; Glucagon; Insulinoma; Isoproterenol; Pancreatic Neoplasms; Phosphoproteins; Phosphorylation; Pituitary Neoplasms; Potassium; Rats; Tetradecanoylphorbol Acetate | 1986 |
Structure, function, and immunogenicity of human insulinoma cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenoma, Islet Cell; Adult; C-Peptide; Fluorescent Antibody Technique; Glucagon; Glucose; Humans; Insulin; Insulin Secretion; Insulinoma; Lymphocyte Culture Test, Mixed; Lymphocytes; Microscopy, Electron; Pancreatic Neoplasms; Tolbutamide; Tumor Cells, Cultured | 1988 |
Myelin basic protein present in the acid extracts of rat hypothalami releases insulin and glucagon from isolated rat pancreatic islets.
Topics: Amino Acids; Animals; Biological Assay; Cell Line, Transformed; Glucagon; Hypothalamus; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Molecular Weight; Myelin Basic Protein; Neutralization Tests; Pancreatic Neoplasms; Radioimmunoassay; Rats; Tissue Extracts | 1988 |
Aggravation of hypoglycemia in insulinoma patients by the long-acting somatostatin analogue octreotide (Sandostatin).
Topics: Adenoma, Islet Cell; Aged; C-Peptide; Female; Glucagon; Humans; Hypoglycemia; Insulin; Insulinoma; Octreotide; Pancreatic Neoplasms | 1989 |
Characterization of the receptor for glucagon-like peptide-1(7-36)amide on plasma membranes from rat insulinoma-derived cells by covalent cross-linking.
Topics: Adenoma, Islet Cell; Animals; Cell Line; Cell Membrane; Cross-Linking Reagents; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Insulinoma; Peptides; Rats; Receptors, Cell Surface; Receptors, Glucagon | 1989 |
Signal transmission after GLP-1(7-36)amide binding in RINm5F cells.
Topics: Adenoma, Islet Cell; Animals; Calcium; Cell Line; Cell Membrane; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Insulinoma; Membrane Potentials; Peptide Fragments; Peptides; Rats; Signal Transduction; Tumor Cells, Cultured | 1989 |
Internalization of glucagon-like peptide-1(7-36)amide in rat insulinoma cells.
Topics: Adenoma, Islet Cell; Animals; Chloroquine; Chromatography, High Pressure Liquid; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Insulinoma; Kinetics; Pancreatic Neoplasms; Peptides; Rats; Receptors, Cell Surface; Receptors, Glucagon; Temperature; Tumor Cells, Cultured | 1989 |
A case of multiple endocrine neoplasia (MEN) type 1; the immunohistochemical and ultrastructural studies of its tumors and the analysis of hormones in tumor extracts.
Topics: Adenoma; Adenoma, Islet Cell; Adult; Chromatography, Gel; Chromatography, High Pressure Liquid; Female; Glucagon; Humans; Immunoenzyme Techniques; Immunohistochemistry; Insulin; Insulinoma; Microscopy, Electron; Molecular Weight; Multiple Endocrine Neoplasia; Pancreatic Neoplasms; Pancreatic Polypeptide; Parathyroid Hormone; Parathyroid Neoplasms; Pituitary Neoplasms; Somatostatin | 1989 |
The endocrine pancreas in patients with insulinomas. An immunocytochemical and ultrastructural study of the nontumoral tissue with morphometrical evaluations.
Topics: Adenoma, Islet Cell; Adult; Aged; Cell Division; Cytophotometry; Female; Glucagon; Humans; Immunoenzyme Techniques; Insulin; Insulinoma; Islets of Langerhans; Male; Microscopy, Electron; Middle Aged; Pancreatic Hormones; Pancreatic Neoplasms; Pancreatic Polypeptide; Somatostatin | 1989 |
Interaction of glucagon-like peptide-1(7-36)amide and somatostatin-14 in RINm5F cells and in the perfused rat pancreas.
Topics: Adenoma, Islet Cell; Animals; Cell Line; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Insulin; Insulinoma; Male; Pancreas; Peptide Fragments; Peptides; Rats; Somatostatin; Tumor Cells, Cultured | 1989 |
Truncated glucagon-like peptide-1 (proglucagon 78-107 amide), an intestinal insulin-releasing peptide, has specific receptors on rat insulinoma cells (RIN 5AH).
Topics: Adenoma, Islet Cell; Animals; Binding, Competitive; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Insulin; Insulinoma; Intestinal Mucosa; Intestines; Kinetics; Pancreatic Neoplasms; Peptides; Rats; Receptors, Cell Surface; Receptors, Glucagon | 1988 |
Receptors for glucagon-like peptide-1(7-36) amide on rat insulinoma-derived cells.
Topics: Adenoma, Islet Cell; Animals; Binding, Competitive; Cell Line; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Insulinoma; Intestinal Mucosa; Jejunum; Pancreatic Neoplasms; Peptide Fragments; Peptides; Rats; Receptors, Cell Surface; Receptors, Glucagon | 1988 |
Characterization of secretory responses of a glucagon-producing In-R1-G9 cell line.
Topics: Adenoma, Islet Cell; Animals; Calcium; Clone Cells; Colchicine; Cricetinae; Cycloheximide; Cytoplasmic Granules; Glucagon; Insulinoma; Monensin; Pancreatic Neoplasms; Tumor Cells, Cultured | 1988 |
The use of glucagon challenge tests in the diagnostic evaluation of hypoglycemia due to hepatoma and insulinoma.
Topics: Adenoma, Islet Cell; Adult; Aged; Aged, 80 and over; Blood Glucose; C-Peptide; Carcinoma, Hepatocellular; Female; Glucagon; Humans; Hypoglycemia; Insulin; Insulinoma; Liver Neoplasms; Male; Middle Aged; Pancreatic Neoplasms | 1988 |
Symptomatic secondary hormone syndromes in patients with established malignant pancreatic endocrine tumors.
Topics: Adenoma, Islet Cell; Adult; Aged; Gastrins; Gastrointestinal Hemorrhage; Glucagon; Glucagonoma; Hormones; Humans; Insulinoma; Middle Aged; Pancreatic Neoplasms; Time Factors; Vasoactive Intestinal Peptide; Vipoma; Zollinger-Ellison Syndrome | 1988 |
[Iatrogenic glucagonoma syndrome?].
Topics: Adenoma, Islet Cell; Amino Acids; Female; Glucagon; Glucagonoma; Humans; Hypoglycemia; Iatrogenic Disease; Insulinoma; Middle Aged; Pancreatic Neoplasms; Skin Diseases; Syndrome | 1988 |
[Features of incretory function of the pancreas in patients with insulinoma].
Topics: Adenoma, Islet Cell; Adolescent; Adult; Blood Glucose; C-Peptide; Female; Glucagon; Humans; Insulin; Insulinoma; Male; Middle Aged; Pancreatic Hormones; Pancreatic Neoplasms; Predictive Value of Tests | 1988 |
Nesidioblastosis and endocrine hyperplasia of the pancreas: a secondary phenomenon.
Topics: Adult; Aged; Child, Preschool; Glucagon; Humans; Hyperinsulinism; Hyperplasia; Infant; Infant, Newborn; Insulin; Insulinoma; Islets of Langerhans; Middle Aged; Pancreas; Pancreatic Diseases; Pancreatic Neoplasms; Pancreatic Polypeptide; Somatostatin | 1986 |
Isolation of glucagon-secreting cell lines by cloning insulinoma cells.
Topics: Adenoma, Islet Cell; Animals; Clone Cells; Cricetinae; Culture Media; Glucagon; Glucose; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Karyotyping; Microscopy, Electron; Pancreatic Neoplasms; Somatostatin | 1986 |
Effects of transplantation and resection of a radiation-induced rat insulinoma on glucose homeostasis and the endocrine pancreas.
Topics: Adenoma, Islet Cell; Animals; Blood Glucose; Glucagon; Glucose; Homeostasis; Insulin; Insulinoma; Islets of Langerhans; Male; Neoplasm Transplantation; Neoplasms, Radiation-Induced; Pancreatic Neoplasms; Rats; Rats, Inbred Strains; Somatostatin | 1986 |
Multipotential phenotypic expression of genes encoding peptide hormones in rat insulinoma cell lines.
Topics: Adenoma, Islet Cell; Animals; Cell Line; Clone Cells; Genes; Glucagon; Insulin; Insulinoma; Nucleic Acid Hybridization; Pancreatic Neoplasms; Pancreatic Polypeptide; Phenotype; Protein Biosynthesis; Rats; Somatostatin | 1987 |
Metabolic effects and secretory properties of a radiation-induced transplantable rat insulinoma.
Topics: Adenoma, Islet Cell; Animals; Arginine; Blood Glucose; Body Weight; Deoxyglucose; Epinephrine; Feeding Behavior; Glucagon; Glyburide; Insulin; Insulinoma; Male; Neoplasms, Radiation-Induced; Pancreatic Neoplasms; Rats; Rats, Inbred Strains | 1987 |
Distribution of somatostatin receptors in RINm5F insulinoma cells.
Topics: Adenoma, Islet Cell; Animals; Cell Fractionation; Cell Membrane; Colforsin; Cytoplasmic Granules; Cytosol; Glucagon; Glyceraldehyde; Insulin; Insulin Secretion; Insulinoma; Iodine Radioisotopes; Kinetics; Leucine; Microsomes; Pancreatic Neoplasms; Rats; Receptors, Neurotransmitter; Receptors, Somatostatin; Somatostatin; Tumor Cells, Cultured | 1988 |
Remission of symptoms of chemotherapy-refractory metastatic insulinoma using octreotide.
Topics: Adenoma, Islet Cell; Antineoplastic Agents; Drug Resistance; Female; Gastrins; Glucagon; Humans; Insulin; Insulinoma; Middle Aged; Neoplasm Metastasis; Octreotide; Pancreatic Neoplasms; Somatostatin | 1988 |
Expression of peptide hormone genes in human islet cell tumors.
Topics: Adenoma, Islet Cell; Animals; Blotting, Northern; Genes; Glucagon; Glucagonoma; Humans; Insulin; Insulinoma; Pancreatic Neoplasms; Pancreatic Polypeptide; Rats; RNA, Messenger; Somatostatin | 1988 |
Streptozotocin effective for treating multiple-hormone-producing malignant islet cell tumor.
Topics: Adenoma, Islet Cell; Blood Glucose; C-Peptide; Female; Glucagon; Humans; Insulin; Insulinoma; Liver Neoplasms; Middle Aged; Pancreatic Neoplasms; Serotonin; Streptozocin | 1985 |
Characteristics of the interaction of the glucagon receptor, cAMP, and insulin secretion in parent cells and clone 5F of a cultured rat insulinoma.
Topics: Adenoma, Islet Cell; Amino Acids; Animals; Cell Line; Clone Cells; Cyclic AMP; Deoxyglucose; Glucagon; Insulin; Insulin Secretion; Insulinoma; Pancreatic Neoplasms; Rats; Receptors, Cell Surface; Receptors, Glucagon | 1985 |
[Biochemical diagnosis of insulinoma: correlations between blood glucose, blood insulin and the titer of plasma non-esterified fatty acids during fasting and during various diagnostic tests].
Topics: Adenoma, Islet Cell; Adult; Aged; Blood Glucose; C-Peptide; Epinephrine; Fasting; Fatty Acids, Nonesterified; Female; Glucagon; Glucose Tolerance Test; Humans; Insulin; Insulinoma; Male; Middle Aged; Tolbutamide | 1985 |
Accurate localization of insulinoma using percutaneous transhepatic portal venous sampling--usefulness of simultaneous measurement of plasma insulin and glucagon levels.
Topics: Adenoma, Islet Cell; Adult; Aged; Blood Specimen Collection; Female; Glucagon; Humans; Insulin; Insulinoma; Male; Middle Aged; Pancreatic Neoplasms; Portal Vein | 1985 |
Neoplasia and hyperplasia of pancreatic endocrine tissue in the rat: an immunocytochemical study.
Topics: Adenoma, Islet Cell; Animals; Female; Glucagon; Hyperplasia; Immunoassay; Insulin; Insulinoma; Islets of Langerhans; Male; Pancreatic Neoplasms; Rats; Rats, Inbred Strains; Species Specificity | 1986 |
Effect of phorbol esters on glucagon secretion from a glucagon-secreting clonal cell line. Synergistic effects of A23187 and theophylline.
Topics: Adenoma, Islet Cell; Animals; Calcimycin; Cell Line; Clone Cells; Cricetinae; Drug Synergism; Glucagon; In Vitro Techniques; Insulinoma; Pancreatic Neoplasms; Phorbols; Tetradecanoylphorbol Acetate; Theophylline | 1986 |
Effects of a transplantable insulinoma upon regulatory peptide concentrations in the gastrointestinal tract of the rat.
Topics: Adenoma, Islet Cell; Animals; Blood Glucose; Eating; Energy Intake; Gastrointestinal Hormones; Glucagon; Insulin; Insulinoma; Male; Neoplasm Transplantation; Pancreatic Neoplasms; Rats; Rats, Inbred Strains | 1986 |
[Studies on the diagnosis of insulinoma].
Topics: Adenoma, Islet Cell; Adolescent; Adult; Aged; Blood Glucose; C-Peptide; Female; Glucagon; Humans; Insulin; Insulin Secretion; Insulinoma; Male; Middle Aged; Pancreatic Neoplasms; Tolbutamide | 1987 |
Proglucagon gene expression and posttranslational processing in a hamster islet cell line.
Topics: Animals; Cell Line; Cricetinae; Genes; Glucagon; Insulinoma; Methylation; Pancreatic Neoplasms; Proglucagon; Protein Precursors; Protein Processing, Post-Translational; RNA, Neoplasm; Transcription, Genetic | 1988 |
Interaction of glucagon-like peptide-I (7-37) and somatostatin-14 on signal transduction and proinsulin gene expression in beta TC-1 cells.
Topics: Adenylyl Cyclases; Animals; Colforsin; Cyclic AMP; Drug Interactions; Gene Expression; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Insulinoma; Mice; Pancreatic Neoplasms; Peptides; Proinsulin; Receptors, Cell Surface; Receptors, Glucagon; Signal Transduction; Somatostatin; Tumor Cells, Cultured | 1994 |