glu-asp-arg and Hemolysis

Biological effects of short regulatory peptides, pinealon, vesugen, vilon and epitalon were studied in model experiments in vitro. These peptides were found not to demonstrate direct antioxidant activity but be able to restrict lipid peroxidation of human lipoproteins by modification of their structure. The short peptides increase stability of red blood cell membranes toward osmotic hemolysis. They also elevate the stationary level of intracellular reactive oxygen species and at the same time decrease (all excepting epitalon) percent of dead cells in neuronal population. The suggestion was made that under in vivo conditions, short peptides may participate in apoptosis/necrosis regulation.

Topics: Adenosine Triphosphate; Animals; Antioxidants; Erythrocytes; Hemolysis; Humans; In Vitro Techniques; Lipoproteins; Neurons; Oligopeptides; Oxidation-Reduction; Rats; Rats, Wistar; Reactive Nitrogen Species